Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q96Q91

- B3A4_HUMAN

UniProt

Q96Q91 - B3A4_HUMAN

Protein

Anion exchange protein 4

Gene

SLC4A9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 2 (28 Mar 2003)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Probable apical anion exchanger of the kidney cortex.By similarity

    GO - Molecular functioni

    1. inorganic anion exchanger activity Source: InterPro

    GO - Biological processi

    1. bicarbonate transport Source: Reactome
    2. ion transport Source: Reactome
    3. transmembrane transport Source: Reactome

    Keywords - Biological processi

    Anion exchange, Antiport, Ion transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_19298. Bicarbonate transporters.

    Protein family/group databases

    TCDBi2.A.31.2.13. the anion exchanger (ae) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Anion exchange protein 4
    Short name:
    AE 4
    Short name:
    Anion exchanger 4
    Alternative name(s):
    Sodium bicarbonate cotransporter 5
    Solute carrier family 4 member 9
    Gene namesi
    Name:SLC4A9
    Synonyms:AE4, SBC5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:11035. SLC4A9.

    Subcellular locationi

    GO - Cellular componenti

    1. apical part of cell Source: Ensembl
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35901.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 983983Anion exchange protein 4PRO_0000079223Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi576 – 5761N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi600 – 6001N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ96Q91.
    PRIDEiQ96Q91.

    PTM databases

    PhosphoSiteiQ96Q91.

    Expressioni

    Tissue specificityi

    Kidney specific.2 Publications

    Gene expression databases

    BgeeiQ96Q91.
    CleanExiHS_SLC4A9.
    GenevestigatoriQ96Q91.

    Organism-specific databases

    HPAiHPA051307.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000387708.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96Q91.
    SMRiQ96Q91. Positions 101-324.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 414414CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini551 – 62373ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini686 – 71126CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei415 – 43521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei443 – 46321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei465 – 48521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei500 – 52021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei530 – 55021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei624 – 64421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei665 – 68521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei712 – 73221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei758 – 77821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei815 – 83521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei837 – 85721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei899 – 91921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni415 – 983569Membrane (anion exchange)Add
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG301727.
    HOVERGENiHBG004326.
    InParanoidiQ96Q91.
    KOiK13860.
    OMAiQELLWLD.
    OrthoDBiEOG7TMZR0.
    PhylomeDBiQ96Q91.
    TreeFamiTF313630.

    Family and domain databases

    Gene3Di3.40.1100.10. 1 hit.
    InterProiIPR013769. Band3_cytoplasmic_dom.
    IPR011531. HCO3_transpt_C.
    IPR003020. HCO3_transpt_euk.
    IPR003024. Na/HCO3_transpt.
    IPR016152. PTrfase/Anion_transptr.
    [Graphical view]
    PANTHERiPTHR11453. PTHR11453. 1 hit.
    PfamiPF07565. Band_3_cyto. 2 hits.
    PF00955. HCO3_cotransp. 1 hit.
    [Graphical view]
    PRINTSiPR01231. HCO3TRNSPORT.
    PR01232. NAHCO3TRSPRT.
    SUPFAMiSSF55804. SSF55804. 1 hit.
    TIGRFAMsiTIGR00834. ae. 1 hit.

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96Q91-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEMKLPGQEG FEASSAPRNI PSGELDSNPD PGTGPSPDGP SDTESKELGV    50
    PKDPLLFIQL NELLGWPQAL EWRETGSSSA SLLLDMGEMP SITLSTHLHH 100
    RWVLFEEKLE VAAGRWSAPH VPTLALPSLQ KLRSLLAEGL VLLDCPAQSL 150
    LELVEQVTRV ESLSPELRGQ LQALLLQRPQ HYNQTTGTRP CWGSTHPRKA 200
    SDNEEAPLRE QCQNPLRQKL PPGAEAGTVL AGELGFLAQP LGAFVRLRNP 250
    VVLGSLTEVS LPSRFFCLLL GPCMLGKGYH EMGRAAAVLL SDPQFQWSVR 300
    RASNLHDLLA ALDAFLEEVT VLPPGRWDPT ARIPPPKCLP SQHKRLPSQQ 350
    REIRGPAVPR LTSAEDRHRH GPHAHSPELQ RTGRLFGGLI QDVRRKVPWY 400
    PSDFLDALHL QCFSAVLYIY LATVTNAITF GGLLGDATDG AQGVLESFLG 450
    TAVAGAAFCL MAGQPLTILS STGPVLVFER LLFSFSRDYS LDYLPFRLWV 500
    GIWVATFCLV LVATEASVLV RYFTRFTEEG FCALISLIFI YDAVGKMLNL 550
    THTYPIQKPG SSAYGCLCQY PGPGGNESQW IRTRPKDRDD IVSMDLGLIN 600
    ASLLPPPECT RQGGHPRGPG CHTVPDIAFF SLLLFLTSFF FAMALKCVKT 650
    SRFFPSVVRK GLSDFSSVLA ILLGCGLDAF LGLATPKLMV PREFKPTLPG 700
    RGWLVSPFGA NPWWWSVAAA LPALLLSILI FMDQQITAVI LNRMEYRLQK 750
    GAGFHLDLFC VAVLMLLTSA LGLPWYVSAT VISLAHMDSL RRESRACAPG 800
    ERPNFLGIRE QRLTGLVVFI LTGASIFLAP VLKFIPMPVL YGIFLYMGVA 850
    ALSSIQFTNR VKLLLMPAKH QPDLLLLRHV PLTRVHLFTA IQLACLGLLW 900
    IIKSTPAAII FPLMLLGLVG VRKALERVFS PQELLWLDEL MPEEERSIPE 950
    KGLEPEHSFS GSDSEDSELM YQPKAPEINI SVN 983
    Length:983
    Mass (Da):108,248
    Last modified:March 28, 2003 - v2
    Checksum:iE2AEB04C9D27E6BC
    GO
    Isoform 2 (identifier: Q96Q91-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         77-100: Missing.
         384-394: Missing.
         592-594: Missing.

    Show »
    Length:945
    Mass (Da):104,128
    Checksum:i4221B3EF5309C1C0
    GO
    Isoform 3 (identifier: Q96Q91-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         77-100: Missing.

    Show »
    Length:959
    Mass (Da):105,701
    Checksum:i2B190D6A5D2E346C
    GO
    Isoform 4 (identifier: Q96Q91-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         77-100: Missing.
         595-657: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:896
    Mass (Da):98,851
    Checksum:iB6E908619855FCCC
    GO

    Sequence cautioni

    The sequence AAK28832.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti23 – 231G → W in AAI36263. (PubMed:15489334)Curated
    Sequence conflicti23 – 231G → W in AAI43603. (PubMed:15489334)Curated
    Sequence conflicti101 – 1011R → T in AAK69625. 1 PublicationCurated
    Sequence conflicti453 – 4531V → M in AAK16733. (PubMed:11302728)Curated
    Sequence conflicti795 – 7951R → K in AAK16733. (PubMed:11302728)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei77 – 10024Missing in isoform 2, isoform 3 and isoform 4. 4 PublicationsVSP_007085Add
    BLAST
    Alternative sequencei384 – 39411Missing in isoform 2. 1 PublicationVSP_007086Add
    BLAST
    Alternative sequencei592 – 5943Missing in isoform 2. 1 PublicationVSP_007087
    Alternative sequencei595 – 65763Missing in isoform 4. 1 PublicationVSP_044785Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF336237 mRNA. Translation: AAK16733.1.
    AF313465 mRNA. Translation: AAK28832.1. Different initiation.
    AF332961 mRNA. Translation: AAK69625.1.
    AC008438 Genomic DNA. No translation available.
    CH471062 Genomic DNA. Translation: EAW62062.1.
    CH471062 Genomic DNA. Translation: EAW62063.1.
    CH471062 Genomic DNA. Translation: EAW62064.1.
    CH471062 Genomic DNA. Translation: EAW62066.1.
    CH471062 Genomic DNA. Translation: EAW62067.1.
    CH471062 Genomic DNA. Translation: EAW62068.1.
    BC136262 mRNA. Translation: AAI36263.1.
    BC143602 mRNA. Translation: AAI43603.1.
    AB032762 mRNA. Translation: BAA93010.1.
    CCDSiCCDS47278.1. [Q96Q91-3]
    CCDS58973.1. [Q96Q91-1]
    CCDS58974.1. [Q96Q91-4]
    CCDS58975.1. [Q96Q91-2]
    RefSeqiNP_001245355.1. NM_001258426.1. [Q96Q91-2]
    NP_001245356.1. NM_001258427.1. [Q96Q91-4]
    NP_001245357.1. NM_001258428.1. [Q96Q91-1]
    NP_113655.2. NM_031467.2. [Q96Q91-3]
    XP_005268578.1. XM_005268521.1. [Q96Q91-3]
    UniGeneiHs.550313.

    Genome annotation databases

    EnsembliENST00000432095; ENSP00000410056; ENSG00000113073. [Q96Q91-2]
    ENST00000506545; ENSP00000422855; ENSG00000113073. [Q96Q91-4]
    ENST00000506757; ENSP00000424424; ENSG00000113073. [Q96Q91-3]
    ENST00000507527; ENSP00000427661; ENSG00000113073. [Q96Q91-1]
    GeneIDi83697.
    KEGGihsa:83697.
    UCSCiuc003lfj.2. human. [Q96Q91-3]
    uc003lfk.2. human. [Q96Q91-2]
    uc003lfm.3. human. [Q96Q91-1]

    Polymorphism databases

    DMDMi29427950.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF336237 mRNA. Translation: AAK16733.1 .
    AF313465 mRNA. Translation: AAK28832.1 . Different initiation.
    AF332961 mRNA. Translation: AAK69625.1 .
    AC008438 Genomic DNA. No translation available.
    CH471062 Genomic DNA. Translation: EAW62062.1 .
    CH471062 Genomic DNA. Translation: EAW62063.1 .
    CH471062 Genomic DNA. Translation: EAW62064.1 .
    CH471062 Genomic DNA. Translation: EAW62066.1 .
    CH471062 Genomic DNA. Translation: EAW62067.1 .
    CH471062 Genomic DNA. Translation: EAW62068.1 .
    BC136262 mRNA. Translation: AAI36263.1 .
    BC143602 mRNA. Translation: AAI43603.1 .
    AB032762 mRNA. Translation: BAA93010.1 .
    CCDSi CCDS47278.1. [Q96Q91-3 ]
    CCDS58973.1. [Q96Q91-1 ]
    CCDS58974.1. [Q96Q91-4 ]
    CCDS58975.1. [Q96Q91-2 ]
    RefSeqi NP_001245355.1. NM_001258426.1. [Q96Q91-2 ]
    NP_001245356.1. NM_001258427.1. [Q96Q91-4 ]
    NP_001245357.1. NM_001258428.1. [Q96Q91-1 ]
    NP_113655.2. NM_031467.2. [Q96Q91-3 ]
    XP_005268578.1. XM_005268521.1. [Q96Q91-3 ]
    UniGenei Hs.550313.

    3D structure databases

    ProteinModelPortali Q96Q91.
    SMRi Q96Q91. Positions 101-324.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000387708.

    Protein family/group databases

    TCDBi 2.A.31.2.13. the anion exchanger (ae) family.

    PTM databases

    PhosphoSitei Q96Q91.

    Polymorphism databases

    DMDMi 29427950.

    Proteomic databases

    PaxDbi Q96Q91.
    PRIDEi Q96Q91.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000432095 ; ENSP00000410056 ; ENSG00000113073 . [Q96Q91-2 ]
    ENST00000506545 ; ENSP00000422855 ; ENSG00000113073 . [Q96Q91-4 ]
    ENST00000506757 ; ENSP00000424424 ; ENSG00000113073 . [Q96Q91-3 ]
    ENST00000507527 ; ENSP00000427661 ; ENSG00000113073 . [Q96Q91-1 ]
    GeneIDi 83697.
    KEGGi hsa:83697.
    UCSCi uc003lfj.2. human. [Q96Q91-3 ]
    uc003lfk.2. human. [Q96Q91-2 ]
    uc003lfm.3. human. [Q96Q91-1 ]

    Organism-specific databases

    CTDi 83697.
    GeneCardsi GC05P139719.
    H-InvDB HIX0031939.
    HGNCi HGNC:11035. SLC4A9.
    HPAi HPA051307.
    MIMi 610207. gene.
    neXtProti NX_Q96Q91.
    PharmGKBi PA35901.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG301727.
    HOVERGENi HBG004326.
    InParanoidi Q96Q91.
    KOi K13860.
    OMAi QELLWLD.
    OrthoDBi EOG7TMZR0.
    PhylomeDBi Q96Q91.
    TreeFami TF313630.

    Enzyme and pathway databases

    Reactomei REACT_19298. Bicarbonate transporters.

    Miscellaneous databases

    GenomeRNAii 83697.
    NextBioi 72674.
    PROi Q96Q91.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q96Q91.
    CleanExi HS_SLC4A9.
    Genevestigatori Q96Q91.

    Family and domain databases

    Gene3Di 3.40.1100.10. 1 hit.
    InterProi IPR013769. Band3_cytoplasmic_dom.
    IPR011531. HCO3_transpt_C.
    IPR003020. HCO3_transpt_euk.
    IPR003024. Na/HCO3_transpt.
    IPR016152. PTrfase/Anion_transptr.
    [Graphical view ]
    PANTHERi PTHR11453. PTHR11453. 1 hit.
    Pfami PF07565. Band_3_cyto. 2 hits.
    PF00955. HCO3_cotransp. 1 hit.
    [Graphical view ]
    PRINTSi PR01231. HCO3TRNSPORT.
    PR01232. NAHCO3TRSPRT.
    SUPFAMi SSF55804. SSF55804. 1 hit.
    TIGRFAMsi TIGR00834. ae. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Human BTR1, a new bicarbonate transporter superfamily member and human AE4 from kidney."
      Parker M.D., Ourmozdi E.P., Tanner M.J.A.
      Biochem. Biophys. Res. Commun. 282:1103-1109(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Kidney and Testis.
    2. "A novel sodium bicarbonate cotransporter-like gene in an ancient duplicated region: SLC4A9 at 5q31."
      Lipovich L., Lynch E.D., Lee M.K., King M.-C.
      Genome Biol. 2:RESEARCH0011.1-RESEARCH0011.13(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
      Tissue: Kidney.
    3. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Cloning and characterization of human AE4."
      Karet F.E.
      Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
      Tissue: Lung, Placenta and Testis.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "Molecular cloning of human sodium bicarbonate cotransporter 5."
      Ishibashi K.
      Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3-983 (ISOFORM 3), TISSUE SPECIFICITY.
      Tissue: Testis.

    Entry informationi

    Entry nameiB3A4_HUMAN
    AccessioniPrimary (citable) accession number: Q96Q91
    Secondary accession number(s): B7ZL63
    , D3DQD4, D3DQD5, D3DQD6, E9PDK1, Q96RM5, Q9BXF2, Q9BXN3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 28, 2003
    Last sequence update: March 28, 2003
    Last modified: October 1, 2014
    This is version 116 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3