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Protein

Anion exchange protein 4

Gene

SLC4A9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Probable apical anion exchanger of the kidney cortex.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Anion exchange, Antiport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-425381. Bicarbonate transporters.

Protein family/group databases

TCDBi2.A.31.2.13. the anion exchanger (ae) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Anion exchange protein 4
Short name:
AE 4
Short name:
Anion exchanger 4
Alternative name(s):
Sodium bicarbonate cotransporter 5
Solute carrier family 4 member 9
Gene namesi
Name:SLC4A9
Synonyms:AE4, SBC5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:11035. SLC4A9.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 414CytoplasmicSequence analysisAdd BLAST414
Transmembranei415 – 435HelicalSequence analysisAdd BLAST21
Transmembranei443 – 463HelicalSequence analysisAdd BLAST21
Transmembranei465 – 485HelicalSequence analysisAdd BLAST21
Transmembranei500 – 520HelicalSequence analysisAdd BLAST21
Transmembranei530 – 550HelicalSequence analysisAdd BLAST21
Topological domaini551 – 623ExtracellularSequence analysisAdd BLAST73
Transmembranei624 – 644HelicalSequence analysisAdd BLAST21
Transmembranei665 – 685HelicalSequence analysisAdd BLAST21
Topological domaini686 – 711CytoplasmicSequence analysisAdd BLAST26
Transmembranei712 – 732HelicalSequence analysisAdd BLAST21
Transmembranei758 – 778HelicalSequence analysisAdd BLAST21
Transmembranei815 – 835HelicalSequence analysisAdd BLAST21
Transmembranei837 – 857HelicalSequence analysisAdd BLAST21
Transmembranei899 – 919HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi83697.
OpenTargetsiENSG00000113073.
PharmGKBiPA35901.

Polymorphism and mutation databases

BioMutaiSLC4A9.
DMDMi29427950.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000792231 – 983Anion exchange protein 4Add BLAST983

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi566 ↔ 568By similarity
Glycosylationi576N-linked (GlcNAc...)Sequence analysis1
Glycosylationi600N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi609 ↔ 621By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ96Q91.
PeptideAtlasiQ96Q91.
PRIDEiQ96Q91.

PTM databases

iPTMnetiQ96Q91.
PhosphoSitePlusiQ96Q91.

Expressioni

Tissue specificityi

Kidney specific.2 Publications

Gene expression databases

BgeeiENSG00000113073.
CleanExiHS_SLC4A9.
GenevisibleiQ96Q91. HS.

Organism-specific databases

HPAiHPA051307.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000424424.

Structurei

3D structure databases

ProteinModelPortaliQ96Q91.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni415 – 983Membrane (anion exchange)Add BLAST569

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1172. Eukaryota.
ENOG410XPHD. LUCA.
GeneTreeiENSGT00760000119021.
HOGENOMiHOG000280684.
HOVERGENiHBG004326.
InParanoidiQ96Q91.
KOiK13860.
OMAiQELLWLD.
OrthoDBiEOG091G01FT.
PhylomeDBiQ96Q91.
TreeFamiTF313630.

Family and domain databases

Gene3Di3.40.1100.10. 1 hit.
InterProiIPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR003024. Na/HCO3_transpt.
IPR016152. PTrfase/Anion_transptr.
[Graphical view]
PANTHERiPTHR11453. PTHR11453. 2 hits.
PfamiPF07565. Band_3_cyto. 2 hits.
PF00955. HCO3_cotransp. 1 hit.
[Graphical view]
PRINTSiPR01231. HCO3TRNSPORT.
PR01232. NAHCO3TRSPRT.
SUPFAMiSSF55804. SSF55804. 1 hit.
TIGRFAMsiTIGR00834. ae. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96Q91-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEMKLPGQEG FEASSAPRNI PSGELDSNPD PGTGPSPDGP SDTESKELGV
60 70 80 90 100
PKDPLLFIQL NELLGWPQAL EWRETGSSSA SLLLDMGEMP SITLSTHLHH
110 120 130 140 150
RWVLFEEKLE VAAGRWSAPH VPTLALPSLQ KLRSLLAEGL VLLDCPAQSL
160 170 180 190 200
LELVEQVTRV ESLSPELRGQ LQALLLQRPQ HYNQTTGTRP CWGSTHPRKA
210 220 230 240 250
SDNEEAPLRE QCQNPLRQKL PPGAEAGTVL AGELGFLAQP LGAFVRLRNP
260 270 280 290 300
VVLGSLTEVS LPSRFFCLLL GPCMLGKGYH EMGRAAAVLL SDPQFQWSVR
310 320 330 340 350
RASNLHDLLA ALDAFLEEVT VLPPGRWDPT ARIPPPKCLP SQHKRLPSQQ
360 370 380 390 400
REIRGPAVPR LTSAEDRHRH GPHAHSPELQ RTGRLFGGLI QDVRRKVPWY
410 420 430 440 450
PSDFLDALHL QCFSAVLYIY LATVTNAITF GGLLGDATDG AQGVLESFLG
460 470 480 490 500
TAVAGAAFCL MAGQPLTILS STGPVLVFER LLFSFSRDYS LDYLPFRLWV
510 520 530 540 550
GIWVATFCLV LVATEASVLV RYFTRFTEEG FCALISLIFI YDAVGKMLNL
560 570 580 590 600
THTYPIQKPG SSAYGCLCQY PGPGGNESQW IRTRPKDRDD IVSMDLGLIN
610 620 630 640 650
ASLLPPPECT RQGGHPRGPG CHTVPDIAFF SLLLFLTSFF FAMALKCVKT
660 670 680 690 700
SRFFPSVVRK GLSDFSSVLA ILLGCGLDAF LGLATPKLMV PREFKPTLPG
710 720 730 740 750
RGWLVSPFGA NPWWWSVAAA LPALLLSILI FMDQQITAVI LNRMEYRLQK
760 770 780 790 800
GAGFHLDLFC VAVLMLLTSA LGLPWYVSAT VISLAHMDSL RRESRACAPG
810 820 830 840 850
ERPNFLGIRE QRLTGLVVFI LTGASIFLAP VLKFIPMPVL YGIFLYMGVA
860 870 880 890 900
ALSSIQFTNR VKLLLMPAKH QPDLLLLRHV PLTRVHLFTA IQLACLGLLW
910 920 930 940 950
IIKSTPAAII FPLMLLGLVG VRKALERVFS PQELLWLDEL MPEEERSIPE
960 970 980
KGLEPEHSFS GSDSEDSELM YQPKAPEINI SVN
Length:983
Mass (Da):108,248
Last modified:March 28, 2003 - v2
Checksum:iE2AEB04C9D27E6BC
GO
Isoform 2 (identifier: Q96Q91-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     77-100: Missing.
     384-394: Missing.
     592-594: Missing.

Show »
Length:945
Mass (Da):104,128
Checksum:i4221B3EF5309C1C0
GO
Isoform 3 (identifier: Q96Q91-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     77-100: Missing.

Show »
Length:959
Mass (Da):105,701
Checksum:i2B190D6A5D2E346C
GO
Isoform 4 (identifier: Q96Q91-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     77-100: Missing.
     595-657: Missing.

Note: No experimental confirmation available.
Show »
Length:896
Mass (Da):98,851
Checksum:iB6E908619855FCCC
GO

Sequence cautioni

The sequence AAK28832 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23G → W in AAI36263 (PubMed:15489334).Curated1
Sequence conflicti23G → W in AAI43603 (PubMed:15489334).Curated1
Sequence conflicti101R → T in AAK69625 (Ref. 4) Curated1
Sequence conflicti453V → M in AAK16733 (PubMed:11302728).Curated1
Sequence conflicti795R → K in AAK16733 (PubMed:11302728).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00708577 – 100Missing in isoform 2, isoform 3 and isoform 4. 4 PublicationsAdd BLAST24
Alternative sequenceiVSP_007086384 – 394Missing in isoform 2. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_007087592 – 594Missing in isoform 2. 1 Publication3
Alternative sequenceiVSP_044785595 – 657Missing in isoform 4. 1 PublicationAdd BLAST63

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF336237 mRNA. Translation: AAK16733.1.
AF313465 mRNA. Translation: AAK28832.1. Different initiation.
AF332961 mRNA. Translation: AAK69625.1.
AC008438 Genomic DNA. No translation available.
CH471062 Genomic DNA. Translation: EAW62062.1.
CH471062 Genomic DNA. Translation: EAW62063.1.
CH471062 Genomic DNA. Translation: EAW62064.1.
CH471062 Genomic DNA. Translation: EAW62066.1.
CH471062 Genomic DNA. Translation: EAW62067.1.
CH471062 Genomic DNA. Translation: EAW62068.1.
BC136262 mRNA. Translation: AAI36263.1.
BC143602 mRNA. Translation: AAI43603.1.
AB032762 mRNA. Translation: BAA93010.1.
CCDSiCCDS47278.1. [Q96Q91-3]
CCDS58973.1. [Q96Q91-1]
CCDS58974.1. [Q96Q91-4]
CCDS58975.1. [Q96Q91-2]
RefSeqiNP_001245355.1. NM_001258426.1. [Q96Q91-2]
NP_001245356.1. NM_001258427.1. [Q96Q91-4]
NP_001245357.1. NM_001258428.1. [Q96Q91-1]
NP_113655.2. NM_031467.2. [Q96Q91-3]
UniGeneiHs.550313.

Genome annotation databases

EnsembliENST00000432095; ENSP00000410056; ENSG00000113073. [Q96Q91-2]
ENST00000506545; ENSP00000422855; ENSG00000113073. [Q96Q91-4]
ENST00000506757; ENSP00000424424; ENSG00000113073. [Q96Q91-3]
ENST00000507527; ENSP00000427661; ENSG00000113073. [Q96Q91-1]
GeneIDi83697.
KEGGihsa:83697.
UCSCiuc003lfk.3. human. [Q96Q91-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF336237 mRNA. Translation: AAK16733.1.
AF313465 mRNA. Translation: AAK28832.1. Different initiation.
AF332961 mRNA. Translation: AAK69625.1.
AC008438 Genomic DNA. No translation available.
CH471062 Genomic DNA. Translation: EAW62062.1.
CH471062 Genomic DNA. Translation: EAW62063.1.
CH471062 Genomic DNA. Translation: EAW62064.1.
CH471062 Genomic DNA. Translation: EAW62066.1.
CH471062 Genomic DNA. Translation: EAW62067.1.
CH471062 Genomic DNA. Translation: EAW62068.1.
BC136262 mRNA. Translation: AAI36263.1.
BC143602 mRNA. Translation: AAI43603.1.
AB032762 mRNA. Translation: BAA93010.1.
CCDSiCCDS47278.1. [Q96Q91-3]
CCDS58973.1. [Q96Q91-1]
CCDS58974.1. [Q96Q91-4]
CCDS58975.1. [Q96Q91-2]
RefSeqiNP_001245355.1. NM_001258426.1. [Q96Q91-2]
NP_001245356.1. NM_001258427.1. [Q96Q91-4]
NP_001245357.1. NM_001258428.1. [Q96Q91-1]
NP_113655.2. NM_031467.2. [Q96Q91-3]
UniGeneiHs.550313.

3D structure databases

ProteinModelPortaliQ96Q91.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000424424.

Protein family/group databases

TCDBi2.A.31.2.13. the anion exchanger (ae) family.

PTM databases

iPTMnetiQ96Q91.
PhosphoSitePlusiQ96Q91.

Polymorphism and mutation databases

BioMutaiSLC4A9.
DMDMi29427950.

Proteomic databases

PaxDbiQ96Q91.
PeptideAtlasiQ96Q91.
PRIDEiQ96Q91.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000432095; ENSP00000410056; ENSG00000113073. [Q96Q91-2]
ENST00000506545; ENSP00000422855; ENSG00000113073. [Q96Q91-4]
ENST00000506757; ENSP00000424424; ENSG00000113073. [Q96Q91-3]
ENST00000507527; ENSP00000427661; ENSG00000113073. [Q96Q91-1]
GeneIDi83697.
KEGGihsa:83697.
UCSCiuc003lfk.3. human. [Q96Q91-1]

Organism-specific databases

CTDi83697.
DisGeNETi83697.
GeneCardsiSLC4A9.
H-InvDBHIX0031939.
HGNCiHGNC:11035. SLC4A9.
HPAiHPA051307.
MIMi610207. gene.
neXtProtiNX_Q96Q91.
OpenTargetsiENSG00000113073.
PharmGKBiPA35901.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1172. Eukaryota.
ENOG410XPHD. LUCA.
GeneTreeiENSGT00760000119021.
HOGENOMiHOG000280684.
HOVERGENiHBG004326.
InParanoidiQ96Q91.
KOiK13860.
OMAiQELLWLD.
OrthoDBiEOG091G01FT.
PhylomeDBiQ96Q91.
TreeFamiTF313630.

Enzyme and pathway databases

ReactomeiR-HSA-425381. Bicarbonate transporters.

Miscellaneous databases

GenomeRNAii83697.
PROiQ96Q91.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000113073.
CleanExiHS_SLC4A9.
GenevisibleiQ96Q91. HS.

Family and domain databases

Gene3Di3.40.1100.10. 1 hit.
InterProiIPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR003024. Na/HCO3_transpt.
IPR016152. PTrfase/Anion_transptr.
[Graphical view]
PANTHERiPTHR11453. PTHR11453. 2 hits.
PfamiPF07565. Band_3_cyto. 2 hits.
PF00955. HCO3_cotransp. 1 hit.
[Graphical view]
PRINTSiPR01231. HCO3TRNSPORT.
PR01232. NAHCO3TRSPRT.
SUPFAMiSSF55804. SSF55804. 1 hit.
TIGRFAMsiTIGR00834. ae. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiB3A4_HUMAN
AccessioniPrimary (citable) accession number: Q96Q91
Secondary accession number(s): B7ZL63
, D3DQD4, D3DQD5, D3DQD6, E9PDK1, Q96RM5, Q9BXF2, Q9BXN3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: March 28, 2003
Last modified: November 2, 2016
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.