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Q96Q91

- B3A4_HUMAN

UniProt

Q96Q91 - B3A4_HUMAN

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Protein

Anion exchange protein 4

Gene

SLC4A9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Probable apical anion exchanger of the kidney cortex.By similarity

GO - Molecular functioni

  1. inorganic anion exchanger activity Source: InterPro

GO - Biological processi

  1. bicarbonate transport Source: Reactome
  2. ion transport Source: Reactome
  3. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Anion exchange, Antiport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiREACT_19298. Bicarbonate transporters.

Protein family/group databases

TCDBi2.A.31.2.13. the anion exchanger (ae) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Anion exchange protein 4
Short name:
AE 4
Short name:
Anion exchanger 4
Alternative name(s):
Sodium bicarbonate cotransporter 5
Solute carrier family 4 member 9
Gene namesi
Name:SLC4A9
Synonyms:AE4, SBC5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:11035. SLC4A9.

Subcellular locationi

GO - Cellular componenti

  1. apical part of cell Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35901.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 983983Anion exchange protein 4PRO_0000079223Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi576 – 5761N-linked (GlcNAc...)Sequence Analysis
Glycosylationi600 – 6001N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ96Q91.
PRIDEiQ96Q91.

PTM databases

PhosphoSiteiQ96Q91.

Expressioni

Tissue specificityi

Kidney specific.2 Publications

Gene expression databases

BgeeiQ96Q91.
CleanExiHS_SLC4A9.
GenevestigatoriQ96Q91.

Organism-specific databases

HPAiHPA051307.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000387708.

Structurei

3D structure databases

ProteinModelPortaliQ96Q91.
SMRiQ96Q91. Positions 101-324.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 414414CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini551 – 62373ExtracellularSequence AnalysisAdd
BLAST
Topological domaini686 – 71126CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei415 – 43521HelicalSequence AnalysisAdd
BLAST
Transmembranei443 – 46321HelicalSequence AnalysisAdd
BLAST
Transmembranei465 – 48521HelicalSequence AnalysisAdd
BLAST
Transmembranei500 – 52021HelicalSequence AnalysisAdd
BLAST
Transmembranei530 – 55021HelicalSequence AnalysisAdd
BLAST
Transmembranei624 – 64421HelicalSequence AnalysisAdd
BLAST
Transmembranei665 – 68521HelicalSequence AnalysisAdd
BLAST
Transmembranei712 – 73221HelicalSequence AnalysisAdd
BLAST
Transmembranei758 – 77821HelicalSequence AnalysisAdd
BLAST
Transmembranei815 – 83521HelicalSequence AnalysisAdd
BLAST
Transmembranei837 – 85721HelicalSequence AnalysisAdd
BLAST
Transmembranei899 – 91921HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni415 – 983569Membrane (anion exchange)Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG301727.
GeneTreeiENSGT00760000119021.
HOVERGENiHBG004326.
InParanoidiQ96Q91.
KOiK13860.
OMAiQELLWLD.
OrthoDBiEOG7TMZR0.
PhylomeDBiQ96Q91.
TreeFamiTF313630.

Family and domain databases

Gene3Di3.40.1100.10. 1 hit.
InterProiIPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR003024. Na/HCO3_transpt.
IPR016152. PTrfase/Anion_transptr.
[Graphical view]
PANTHERiPTHR11453. PTHR11453. 1 hit.
PfamiPF07565. Band_3_cyto. 2 hits.
PF00955. HCO3_cotransp. 1 hit.
[Graphical view]
PRINTSiPR01231. HCO3TRNSPORT.
PR01232. NAHCO3TRSPRT.
SUPFAMiSSF55804. SSF55804. 1 hit.
TIGRFAMsiTIGR00834. ae. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96Q91-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEMKLPGQEG FEASSAPRNI PSGELDSNPD PGTGPSPDGP SDTESKELGV
60 70 80 90 100
PKDPLLFIQL NELLGWPQAL EWRETGSSSA SLLLDMGEMP SITLSTHLHH
110 120 130 140 150
RWVLFEEKLE VAAGRWSAPH VPTLALPSLQ KLRSLLAEGL VLLDCPAQSL
160 170 180 190 200
LELVEQVTRV ESLSPELRGQ LQALLLQRPQ HYNQTTGTRP CWGSTHPRKA
210 220 230 240 250
SDNEEAPLRE QCQNPLRQKL PPGAEAGTVL AGELGFLAQP LGAFVRLRNP
260 270 280 290 300
VVLGSLTEVS LPSRFFCLLL GPCMLGKGYH EMGRAAAVLL SDPQFQWSVR
310 320 330 340 350
RASNLHDLLA ALDAFLEEVT VLPPGRWDPT ARIPPPKCLP SQHKRLPSQQ
360 370 380 390 400
REIRGPAVPR LTSAEDRHRH GPHAHSPELQ RTGRLFGGLI QDVRRKVPWY
410 420 430 440 450
PSDFLDALHL QCFSAVLYIY LATVTNAITF GGLLGDATDG AQGVLESFLG
460 470 480 490 500
TAVAGAAFCL MAGQPLTILS STGPVLVFER LLFSFSRDYS LDYLPFRLWV
510 520 530 540 550
GIWVATFCLV LVATEASVLV RYFTRFTEEG FCALISLIFI YDAVGKMLNL
560 570 580 590 600
THTYPIQKPG SSAYGCLCQY PGPGGNESQW IRTRPKDRDD IVSMDLGLIN
610 620 630 640 650
ASLLPPPECT RQGGHPRGPG CHTVPDIAFF SLLLFLTSFF FAMALKCVKT
660 670 680 690 700
SRFFPSVVRK GLSDFSSVLA ILLGCGLDAF LGLATPKLMV PREFKPTLPG
710 720 730 740 750
RGWLVSPFGA NPWWWSVAAA LPALLLSILI FMDQQITAVI LNRMEYRLQK
760 770 780 790 800
GAGFHLDLFC VAVLMLLTSA LGLPWYVSAT VISLAHMDSL RRESRACAPG
810 820 830 840 850
ERPNFLGIRE QRLTGLVVFI LTGASIFLAP VLKFIPMPVL YGIFLYMGVA
860 870 880 890 900
ALSSIQFTNR VKLLLMPAKH QPDLLLLRHV PLTRVHLFTA IQLACLGLLW
910 920 930 940 950
IIKSTPAAII FPLMLLGLVG VRKALERVFS PQELLWLDEL MPEEERSIPE
960 970 980
KGLEPEHSFS GSDSEDSELM YQPKAPEINI SVN
Length:983
Mass (Da):108,248
Last modified:March 28, 2003 - v2
Checksum:iE2AEB04C9D27E6BC
GO
Isoform 2 (identifier: Q96Q91-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     77-100: Missing.
     384-394: Missing.
     592-594: Missing.

Show »
Length:945
Mass (Da):104,128
Checksum:i4221B3EF5309C1C0
GO
Isoform 3 (identifier: Q96Q91-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     77-100: Missing.

Show »
Length:959
Mass (Da):105,701
Checksum:i2B190D6A5D2E346C
GO
Isoform 4 (identifier: Q96Q91-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     77-100: Missing.
     595-657: Missing.

Note: No experimental confirmation available.

Show »
Length:896
Mass (Da):98,851
Checksum:iB6E908619855FCCC
GO

Sequence cautioni

The sequence AAK28832.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti23 – 231G → W in AAI36263. (PubMed:15489334)Curated
Sequence conflicti23 – 231G → W in AAI43603. (PubMed:15489334)Curated
Sequence conflicti101 – 1011R → T in AAK69625. 1 PublicationCurated
Sequence conflicti453 – 4531V → M in AAK16733. (PubMed:11302728)Curated
Sequence conflicti795 – 7951R → K in AAK16733. (PubMed:11302728)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei77 – 10024Missing in isoform 2, isoform 3 and isoform 4. 4 PublicationsVSP_007085Add
BLAST
Alternative sequencei384 – 39411Missing in isoform 2. 1 PublicationVSP_007086Add
BLAST
Alternative sequencei592 – 5943Missing in isoform 2. 1 PublicationVSP_007087
Alternative sequencei595 – 65763Missing in isoform 4. 1 PublicationVSP_044785Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF336237 mRNA. Translation: AAK16733.1.
AF313465 mRNA. Translation: AAK28832.1. Different initiation.
AF332961 mRNA. Translation: AAK69625.1.
AC008438 Genomic DNA. No translation available.
CH471062 Genomic DNA. Translation: EAW62062.1.
CH471062 Genomic DNA. Translation: EAW62063.1.
CH471062 Genomic DNA. Translation: EAW62064.1.
CH471062 Genomic DNA. Translation: EAW62066.1.
CH471062 Genomic DNA. Translation: EAW62067.1.
CH471062 Genomic DNA. Translation: EAW62068.1.
BC136262 mRNA. Translation: AAI36263.1.
BC143602 mRNA. Translation: AAI43603.1.
AB032762 mRNA. Translation: BAA93010.1.
CCDSiCCDS47278.1. [Q96Q91-3]
CCDS58973.1. [Q96Q91-1]
CCDS58974.1. [Q96Q91-4]
CCDS58975.1. [Q96Q91-2]
RefSeqiNP_001245355.1. NM_001258426.1. [Q96Q91-2]
NP_001245356.1. NM_001258427.1. [Q96Q91-4]
NP_001245357.1. NM_001258428.1. [Q96Q91-1]
NP_113655.2. NM_031467.2. [Q96Q91-3]
XP_005268578.1. XM_005268521.1. [Q96Q91-3]
UniGeneiHs.550313.

Genome annotation databases

EnsembliENST00000432095; ENSP00000410056; ENSG00000113073. [Q96Q91-2]
ENST00000506545; ENSP00000422855; ENSG00000113073. [Q96Q91-4]
ENST00000506757; ENSP00000424424; ENSG00000113073. [Q96Q91-3]
ENST00000507527; ENSP00000427661; ENSG00000113073. [Q96Q91-1]
GeneIDi83697.
KEGGihsa:83697.
UCSCiuc003lfj.2. human. [Q96Q91-3]
uc003lfk.2. human. [Q96Q91-2]
uc003lfm.3. human. [Q96Q91-1]

Polymorphism databases

DMDMi29427950.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF336237 mRNA. Translation: AAK16733.1 .
AF313465 mRNA. Translation: AAK28832.1 . Different initiation.
AF332961 mRNA. Translation: AAK69625.1 .
AC008438 Genomic DNA. No translation available.
CH471062 Genomic DNA. Translation: EAW62062.1 .
CH471062 Genomic DNA. Translation: EAW62063.1 .
CH471062 Genomic DNA. Translation: EAW62064.1 .
CH471062 Genomic DNA. Translation: EAW62066.1 .
CH471062 Genomic DNA. Translation: EAW62067.1 .
CH471062 Genomic DNA. Translation: EAW62068.1 .
BC136262 mRNA. Translation: AAI36263.1 .
BC143602 mRNA. Translation: AAI43603.1 .
AB032762 mRNA. Translation: BAA93010.1 .
CCDSi CCDS47278.1. [Q96Q91-3 ]
CCDS58973.1. [Q96Q91-1 ]
CCDS58974.1. [Q96Q91-4 ]
CCDS58975.1. [Q96Q91-2 ]
RefSeqi NP_001245355.1. NM_001258426.1. [Q96Q91-2 ]
NP_001245356.1. NM_001258427.1. [Q96Q91-4 ]
NP_001245357.1. NM_001258428.1. [Q96Q91-1 ]
NP_113655.2. NM_031467.2. [Q96Q91-3 ]
XP_005268578.1. XM_005268521.1. [Q96Q91-3 ]
UniGenei Hs.550313.

3D structure databases

ProteinModelPortali Q96Q91.
SMRi Q96Q91. Positions 101-324.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000387708.

Protein family/group databases

TCDBi 2.A.31.2.13. the anion exchanger (ae) family.

PTM databases

PhosphoSitei Q96Q91.

Polymorphism databases

DMDMi 29427950.

Proteomic databases

PaxDbi Q96Q91.
PRIDEi Q96Q91.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000432095 ; ENSP00000410056 ; ENSG00000113073 . [Q96Q91-2 ]
ENST00000506545 ; ENSP00000422855 ; ENSG00000113073 . [Q96Q91-4 ]
ENST00000506757 ; ENSP00000424424 ; ENSG00000113073 . [Q96Q91-3 ]
ENST00000507527 ; ENSP00000427661 ; ENSG00000113073 . [Q96Q91-1 ]
GeneIDi 83697.
KEGGi hsa:83697.
UCSCi uc003lfj.2. human. [Q96Q91-3 ]
uc003lfk.2. human. [Q96Q91-2 ]
uc003lfm.3. human. [Q96Q91-1 ]

Organism-specific databases

CTDi 83697.
GeneCardsi GC05P139719.
H-InvDB HIX0031939.
HGNCi HGNC:11035. SLC4A9.
HPAi HPA051307.
MIMi 610207. gene.
neXtProti NX_Q96Q91.
PharmGKBi PA35901.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG301727.
GeneTreei ENSGT00760000119021.
HOVERGENi HBG004326.
InParanoidi Q96Q91.
KOi K13860.
OMAi QELLWLD.
OrthoDBi EOG7TMZR0.
PhylomeDBi Q96Q91.
TreeFami TF313630.

Enzyme and pathway databases

Reactomei REACT_19298. Bicarbonate transporters.

Miscellaneous databases

GenomeRNAii 83697.
NextBioi 72674.
PROi Q96Q91.
SOURCEi Search...

Gene expression databases

Bgeei Q96Q91.
CleanExi HS_SLC4A9.
Genevestigatori Q96Q91.

Family and domain databases

Gene3Di 3.40.1100.10. 1 hit.
InterProi IPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR003024. Na/HCO3_transpt.
IPR016152. PTrfase/Anion_transptr.
[Graphical view ]
PANTHERi PTHR11453. PTHR11453. 1 hit.
Pfami PF07565. Band_3_cyto. 2 hits.
PF00955. HCO3_cotransp. 1 hit.
[Graphical view ]
PRINTSi PR01231. HCO3TRNSPORT.
PR01232. NAHCO3TRSPRT.
SUPFAMi SSF55804. SSF55804. 1 hit.
TIGRFAMsi TIGR00834. ae. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human BTR1, a new bicarbonate transporter superfamily member and human AE4 from kidney."
    Parker M.D., Ourmozdi E.P., Tanner M.J.A.
    Biochem. Biophys. Res. Commun. 282:1103-1109(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Kidney and Testis.
  2. "A novel sodium bicarbonate cotransporter-like gene in an ancient duplicated region: SLC4A9 at 5q31."
    Lipovich L., Lynch E.D., Lee M.K., King M.-C.
    Genome Biol. 2:RESEARCH0011.1-RESEARCH0011.13(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    Tissue: Kidney.
  3. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Cloning and characterization of human AE4."
    Karet F.E.
    Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Lung, Placenta and Testis.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "Molecular cloning of human sodium bicarbonate cotransporter 5."
    Ishibashi K.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3-983 (ISOFORM 3), TISSUE SPECIFICITY.
    Tissue: Testis.

Entry informationi

Entry nameiB3A4_HUMAN
AccessioniPrimary (citable) accession number: Q96Q91
Secondary accession number(s): B7ZL63
, D3DQD4, D3DQD5, D3DQD6, E9PDK1, Q96RM5, Q9BXF2, Q9BXN3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: March 28, 2003
Last modified: October 29, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3