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Q96Q89 (KI20B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Kinesin-like protein KIF20B
Alternative name(s):
Cancer/testis antigen 90
Short name=CT90
Kinesin-related motor interacting with PIN1
M-phase phosphoprotein 1
Short name=MPP1
Gene names
Name:KIF20B
Synonyms:KRMP1, MPHOSPH1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1820 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plus-end-directed motor enzyme that is required for completion of cytokinesis. Ref.5

Subunit structure

Interacts with PIN1. Ref.1

Subcellular location

Cytoplasm. Nucleus. Cytoplasmcytoskeletonspindle. Note: Localizes mainly in the nucleus during interphase although it is also detected in the cytoplasm without clear association with microtubules. A 2-3 fold expression increase is seen as cells progress from G1 to G2/M phase. During prophase and metaphase it is found throughout the cytoplasm and at anaphase accumulates at the midplan of the cell and forms a distinct band extending across the spindle midzone. At anaphase it is concentrated in the mid-body. Ref.1 Ref.5

Tissue specificity

Brain, ovary, kidney and testis. Ref.5

Sequence similarities

Belongs to the kinesin-like protein family.

Contains 1 kinesin-motor domain.

Sequence caution

The sequence AAH46134.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

The sequence AAH58913.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

The sequence AAH93089.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

The sequence AAI08689.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

The sequence BAB15043.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

The sequence CAI12885.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence CAI16829.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   Biological processCell cycle
Cell division
Mitosis
   Cellular componentCytoplasm
Cytoskeleton
Microtubule
Nucleus
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainCoiled coil
   LigandATP-binding
Nucleotide-binding
   Molecular functionMotor protein
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processATP catabolic process

Inferred from direct assay Ref.1. Source: GOC

cell cycle arrest

Non-traceable author statement Ref.1. Source: UniProtKB

microtubule-based movement

Inferred from electronic annotation. Source: InterPro

mitosis

Inferred from electronic annotation. Source: UniProtKB-KW

mitotic M phase

Traceable author statement PubMed 8885239. Source: ProtInc

regulation of mitosis

Non-traceable author statement Ref.1. Source: UniProtKB

   Cellular_componentcentrosome

Inferred from direct assay Ref.1. Source: UniProtKB

cytoplasm

Inferred from direct assay. Source: HPA

microtubule

Inferred from electronic annotation. Source: UniProtKB-KW

nucleolus

Inferred from direct assay Ref.1. Source: UniProtKB

nucleoplasm

Inferred from direct assay Ref.1. Source: UniProtKB

nucleus

Inferred from direct assay. Source: HPA

spindle

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

ATPase activity

Inferred from direct assay Ref.1. Source: UniProtKB

WW domain binding

Inferred from physical interaction Ref.1. Source: UniProtKB

microtubule motor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q96Q89-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q96Q89-2)

The sequence of this isoform differs from the canonical sequence as follows:
     849-849: G → GTTSAASSRRLRKLISKPKKGVNRTRQTEGHSLV
Isoform 3 (identifier: Q96Q89-3)

The sequence of this isoform differs from the canonical sequence as follows:
     668-707: Missing.
Isoform 4 (identifier: Q96Q89-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1664-1722: DLVKCENKKN...QASIIGVNLA → SASPPPKECS...EVENFEKNLD
     1723-1820: Missing.
Isoform 5 (identifier: Q96Q89-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1308: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 18201820Kinesin-like protein KIF20B
PRO_0000274053

Regions

Domain55 – 405351Kinesin-motor
Nucleotide binding152 – 1598ATP Potential
Region1560 – 1820261Interaction with PIN1
Coiled coil523 – 60381 Potential
Coiled coil674 – 793120 Potential
Compositional bias1247 – 12515Poly-Glu

Amino acid modifications

Modified residue4881Phosphoserine Ref.11
Modified residue9971Phosphoserine By similarity
Modified residue16441Phosphothreonine; by CDK1 Ref.1
Modified residue16581Phosphoserine Ref.12

Natural variations

Alternative sequence1 – 13081308Missing in isoform 5.
VSP_022618
Alternative sequence668 – 70740Missing in isoform 3.
VSP_022619
Alternative sequence8491G → GTTSAASSRRLRKLISKPKK GVNRTRQTEGHSLV in isoform 2.
VSP_022620
Alternative sequence1664 – 172259DLVKC…GVNLA → SASPPPKECSSSPAMEQSWK ENDFDKLREEGFRRSNYSEL QEEIQTKGKEVENFEKNLD in isoform 4.
VSP_022621
Alternative sequence1723 – 182098Missing in isoform 4.
VSP_022622
Natural variant501A → G.
Corresponds to variant rs1129777 [ dbSNP | Ensembl ].
VAR_030181
Natural variant4901E → D. Ref.2 Ref.6
Corresponds to variant rs17484219 [ dbSNP | Ensembl ].
VAR_030182
Natural variant7561N → I. Ref.1 Ref.5
Corresponds to variant rs12572012 [ dbSNP | Ensembl ].
VAR_030183
Natural variant7891H → L. Ref.1 Ref.5
Corresponds to variant rs3758388 [ dbSNP | Ensembl ].
VAR_030184
Natural variant10111D → E.
Corresponds to variant rs1062465 [ dbSNP | Ensembl ].
VAR_030185
Natural variant11271E → Q.
Corresponds to variant rs11185863 [ dbSNP | Ensembl ].
VAR_030186
Natural variant11771C → R. Ref.1 Ref.2 Ref.3 Ref.5 Ref.8 Ref.9
Corresponds to variant rs1886996 [ dbSNP | Ensembl ].
VAR_030187
Natural variant12191N → S.
Corresponds to variant rs1886997 [ dbSNP | Ensembl ].
VAR_030188
Natural variant17891I → V.
Corresponds to variant rs3758390 [ dbSNP | Ensembl ].
VAR_030189

Experimental info

Sequence conflict2661S → T in BAB69456. Ref.1
Sequence conflict296 – 2972KR → NT in BAB69456. Ref.1
Sequence conflict3571V → I in BAB69456. Ref.1
Sequence conflict3881M → V in BAB69456. Ref.1
Sequence conflict5931E → K in AAI08689. Ref.6
Sequence conflict705 – 7073DPQ → ETE in AAP40331. Ref.5
Sequence conflict7531E → K in BAB69456. Ref.1
Sequence conflict7971N → S in BAB15043. Ref.3
Sequence conflict8701N → S in BAB15043. Ref.3
Sequence conflict9151F → S in BAB15043. Ref.3
Sequence conflict11051K → R in BAB15043. Ref.3
Sequence conflict13021V → E in AAC37542. Ref.10
Sequence conflict14591R → S in AAC37542. Ref.10
Sequence conflict16081V → A in BAB69456. Ref.1
Sequence conflict16491K → E in CAB55962. Ref.2
Sequence conflict16491K → E in BAB15194. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 5, 2010. Version 3.
Checksum: 8A6FE95A6F3BA20C

FASTA1,820210,629
        10         20         30         40         50         60 
MESNFNQEGV PRPSYVFSAD PIARPSEINF DGIKLDLSHE FSLVAPNTEA NSFESKDYLQ 

        70         80         90        100        110        120 
VCLRIRPFTQ SEKELESEGC VHILDSQTVV LKEPQCILGR LSEKSSGQMA QKFSFSKVFG 

       130        140        150        160        170        180 
PATTQKEFFQ GCIMQPVKDL LKGQSRLIFT YGLTNSGKTY TFQGTEENIG ILPRTLNVLF 

       190        200        210        220        230        240 
DSLQERLYTK MNLKPHRSRE YLRLSSEQEK EEIASKSALL RQIKEVTVHN DSDDTLYGSL 

       250        260        270        280        290        300 
TNSLNISEFE ESIKDYEQAN LNMANSIKFS VWVSFFEIYN EYIYDLFVPV SSKFQKRKML 

       310        320        330        340        350        360 
RLSQDVKGYS FIKDLQWIQV SDSKEAYRLL KLGIKHQSVA FTKLNNASSR SHSIFTVKIL 

       370        380        390        400        410        420 
QIEDSEMSRV IRVSELSLCD LAGSERTMKT QNEGERLRET GNINTSLLTL GKCINVLKNS 

       430        440        450        460        470        480 
EKSKFQQHVP FRESKLTHYF QSFFNGKGKI CMIVNISQCY LAYDETLNVL KFSAIAQKVC 

       490        500        510        520        530        540 
VPDTLNSSQE KLFGPVKSSQ DVSLDSNSNS KILNVKRATI SWENSLEDLM EDEDLVEELE 

       550        560        570        580        590        600 
NAEETQNVET KLLDEDLDKT LEENKAFISH EEKRKLLDLI EDLKKKLINE KKEKLTLEFK 

       610        620        630        640        650        660 
IREEVTQEFT QYWAQREADF KETLLQEREI LEENAERRLA IFKDLVGKCD TREEAAKDIC 

       670        680        690        700        710        720 
ATKVETEETH NYVGFEDIID SLQDNVADIK KQAEIAHLYI ASLPDPQEAT ACLELKFNQI 

       730        740        750        760        770        780 
KAELAKTKGE LIKTKEELKK RENESDSLIQ ELETSNKKII TQNQRIKELI NIIDQKEDTI 

       790        800        810        820        830        840 
NEFQNLKSHM ENTFKCNDKA DTSSLIINNK LICNETVEVP KDSKSKICSE RKRVNENELQ 

       850        860        870        880        890        900 
QDEPPAKKGS IHVSSAITED QKKSEEVRPN IAEIEDIRVL QENNEGLRAF LLTIENELKN 

       910        920        930        940        950        960 
EKEEKAELNK QIVHFQQELS LSEKKNLTLS KEVQQIQSNY DIAIAELHVQ KSKNQEQEEK 

       970        980        990       1000       1010       1020 
IMKLSNEIET ATRSITNNVS QIKLMHTKID ELRTLDSVSQ ISNIDLLNLR DLSNGSEEDN 

      1030       1040       1050       1060       1070       1080 
LPNTQLDLLG NDYLVSKQVK EYRIQEPNRE NSFHSSIEAI WEECKEIVKA SSKKSHQIEE 

      1090       1100       1110       1120       1130       1140 
LEQQIEKLQA EVKGYKDENN RLKEKEHKNQ DDLLKEKETL IQQLKEELQE KNVTLDVQIQ 

      1150       1160       1170       1180       1190       1200 
HVVEGKRALS ELTQGVTCYK AKIKELETIL ETQKVECSHS AKLEQDILEK ESIILKLERN 

      1210       1220       1230       1240       1250       1260 
LKEFQEHLQD SVKNTKDLNV KELKLKEEIT QLTNNLQDMK HLLQLKEEEE ETNRQETEKL 

      1270       1280       1290       1300       1310       1320 
KEELSASSAR TQNLKADLQR KEEDYADLKE KLTDAKKQIK QVQKEVSVMR DEDKLLRIKI 

      1330       1340       1350       1360       1370       1380 
NELEKKKNQC SQELDMKQRT IQQLKEQLNN QKVEEAIQQY ERACKDLNVK EKIIEDMRMT 

      1390       1400       1410       1420       1430       1440 
LEEQEQTQVE QDQVLEAKLE EVERLATELE KWKEKCNDLE TKNNQRSNKE HENNTDVLGK 

      1450       1460       1470       1480       1490       1500 
LTNLQDELQE SEQKYNADRK KWLEEKMMLI TQAKEAENIR NKEMKKYAED RERFFKQQNE 

      1510       1520       1530       1540       1550       1560 
MEILTAQLTE KDSDLQKWRE ERDQLVAALE IQLKALISSN VQKDNEIEQL KRIISETSKI 

      1570       1580       1590       1600       1610       1620 
ETQIMDIKPK RISSADPDKL QTEPLSTSFE ISRNKIEDGS VVLDSCEVST ENDQSTRFPK 

      1630       1640       1650       1660       1670       1680 
PELEIQFTPL QPNKMAVKHP GCTTPVTVKI PKARKRKSNE MEEDLVKCEN KKNATPRTNL 

      1690       1700       1710       1720       1730       1740 
KFPISDDRNS SVKKEQKVAI RPSSKKTYSL RSQASIIGVN LATKKKEGTL QKFGDFLQHS 

      1750       1760       1770       1780       1790       1800 
PSILQSKAKK IIETMSSSKL SNVEASKENV SQPKRAKRKL YTSEISSPID ISGQVILMDQ 

      1810       1820 
KMKESDHQII KRRLRTKTAK 

« Hide

Isoform 2 [UniParc].

Checksum: 07E7FFF9A7D116C5
Show »

FASTA1,853214,276
Isoform 3 [UniParc].

Checksum: 084B8D31404946E4
Show »

FASTA1,780206,136
Isoform 4 [UniParc].

Checksum: 6B5B4801B38BFF40
Show »

FASTA1,722199,810
Isoform 5 [UniParc].

Checksum: 15D67C1B5D1FBD7B
Show »

FASTA51259,621

References

« Hide 'large scale' references
[1]"Identification of a novel kinesin-related protein, KRMP1, as a target for mitotic peptidyl-prolyl isomerase Pin1."
Kamimoto T., Zama T., Aoki R., Muro Y., Hagiwara M.
J. Biol. Chem. 276:37520-37528(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), SUBCELLULAR LOCATION, INTERACTION WITH PIN1, PHOSPHORYLATION AT THR-1644, VARIANTS ILE-756; LEU-789 AND ARG-1177.
[2]"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. expand/collapse author list , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A.
Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANTS ASP-490 AND ARG-1177.
Tissue: Testis.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 779-1480 (ISOFORMS 1/2/3/4), VARIANT ARG-1177.
Tissue: Colon.
[4]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"M phase phosphoprotein 1 is a human plus-end-directed kinesin-related protein required for cytokinesis."
Abaza A., Soleilhac J.-M., Westendorf J., Piel M., Crevel I., Roux A., Pirollet F.
J. Biol. Chem. 278:27844-27852(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-957 (ISOFORM 3), NUCLEOTIDE SEQUENCE [MRNA] OF 705-1820 (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, VARIANTS ILE-756; LEU-789 AND ARG-1177.
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-740 (ISOFORM 3), VARIANT ASP-490.
Tissue: Lung, Lymph and Testis.
[7]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 575-1820 (ISOFORM 3).
Tissue: Testis.
[8]"Autoantibodies from patients with idiopathic ataxia bind to M-phase phosphoprotein-1 (MPP1)."
Fritzler M.J., Kerfoot S.M., Feasby T.E., Zochodne D.W., Westendorf J.M., Dalmau J.O., Chan E.K.
J. Invest. Med. 48:28-39(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1068-1820 (ISOFORMS 1/2/3), VARIANT ARG-1177.
[9]"Anti-leukemia-specific humoral immune response in children with T-lineage acute lymphoblastic leukemia."
Dohnal A.M., Panzer-Gruemayer R.E.
Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1106-1820 (ISOFORM 4), VARIANT ARG-1177.
[10]"Cloning of cDNAs for M-phase phosphoproteins recognized by the MPM2 monoclonal antibody and determination of the phosphorylated epitope."
Westendorf J.M., Rao P.N., Gerace L.
Proc. Natl. Acad. Sci. U.S.A. 91:714-718(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1255-1820 (ISOFORMS 1/2/3).
[11]"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.
Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-488, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic kidney.
[12]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1658, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB033337 mRNA. Translation: BAB69456.1.
AB033338 mRNA. Translation: BAB20417.1.
AL117496 mRNA. Translation: CAB55962.1.
AK024959 mRNA. Translation: BAB15043.1. Sequence problems.
AK025628 mRNA. Translation: BAB15194.1.
AL157389, AL157400 Genomic DNA. Translation: CAI12885.1. Sequence problems.
AL157389, AL157400 Genomic DNA. Translation: CAI12886.1.
AL157389, AL157400 Genomic DNA. Translation: CAI12887.1.
AL157400, AL157389 Genomic DNA. Translation: CAI16829.1. Sequence problems.
AL157400, AL157389 Genomic DNA. Translation: CAI16830.1.
AL157400, AL157389 Genomic DNA. Translation: CAI16831.1.
AL157400 Genomic DNA. Translation: CAI16832.1.
AY282406 mRNA. Translation: AAP40330.1.
AY282407 mRNA. Translation: AAP40331.1.
BC046134 mRNA. Translation: AAH46134.1. Sequence problems.
BC058913 mRNA. Translation: AAH58913.1. Sequence problems.
BC093089 mRNA. Translation: AAH93089.1. Sequence problems.
BC108688 mRNA. Translation: AAI08689.1. Sequence problems.
AL137392 mRNA. Translation: CAB70720.1.
U93121 mRNA. Translation: AAB88727.1.
AY739715 mRNA. Translation: AAW65984.1.
L16782 mRNA. Translation: AAC37542.1.
PIRT17272.
RefSeqNP_001271188.1. NM_001284259.1.
NP_057279.2. NM_016195.3.
UniGeneHs.240.

3D structure databases

ProteinModelPortalQ96Q89.
SMRQ96Q89. Positions 56-479.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114953. 5 interactions.
DIPDIP-103N.
IntActQ96Q89. 4 interactions.
MINTMINT-4712270.

Chemistry

ChEMBLCHEMBL2021752.

PTM databases

PhosphoSiteQ96Q89.

Polymorphism databases

DMDM308153587.

Proteomic databases

PaxDbQ96Q89.
PRIDEQ96Q89.

Protocols and materials databases

DNASU9585.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000260753; ENSP00000260753; ENSG00000138182. [Q96Q89-3]
ENST00000371728; ENSP00000360793; ENSG00000138182. [Q96Q89-1]
ENST00000394289; ENSP00000377830; ENSG00000138182. [Q96Q89-4]
GeneID9585.
KEGGhsa:9585.
UCSCuc001kgr.1. human. [Q96Q89-3]
uc001kgs.1. human. [Q96Q89-1]

Organism-specific databases

CTD9585.
GeneCardsGC10P091452.
HGNCHGNC:7212. KIF20B.
HPAHPA031263.
HPA050214.
MIM605498. gene.
neXtProtNX_Q96Q89.
PharmGKBPA162393285.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5059.
HOVERGENHBG106760.
InParanoidQ96Q89.
KOK10402.
OrthoDBEOG7TTQ73.
PhylomeDBQ96Q89.
TreeFamTF105232.

Gene expression databases

ArrayExpressQ96Q89.
BgeeQ96Q89.
GenevestigatorQ96Q89.

Family and domain databases

Gene3D3.40.850.10. 2 hits.
InterProIPR028828. KIF20B.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERPTHR23165:SF0. PTHR23165:SF0. 1 hit.
PfamPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSPR00380. KINESINHEAVY.
SMARTSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 2 hits.
PROSITEPS00411. KINESIN_MOTOR_DOMAIN1. 1 hit.
PS50067. KINESIN_MOTOR_DOMAIN2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSKIF20B. human.
GeneWikiMPHOSPH1.
GenomeRNAi9585.
NextBio35959.
PROQ96Q89.
SOURCESearch...

Entry information

Entry nameKI20B_HUMAN
AccessionPrimary (citable) accession number: Q96Q89
Secondary accession number(s): A8MXM7 expand/collapse secondary AC list , O43277, Q09471, Q2KQ73, Q32NE1, Q561V3, Q58EX8, Q5T9M8, Q5T9M9, Q5T9N0, Q5T9N1, Q7KZ68, Q7Z5E0, Q7Z5E1, Q7Z6M9, Q86X82, Q9H3R8, Q9H6Q9, Q9H755, Q9NTC1, Q9UFR5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: October 5, 2010
Last modified: April 16, 2014
This is version 97 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM