Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q96Q89

- KI20B_HUMAN

UniProt

Q96Q89 - KI20B_HUMAN

Protein

Kinesin-like protein KIF20B

Gene

KIF20B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 3 (05 Oct 2010)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Plus-end-directed motor enzyme that is required for completion of cytokinesis.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi152 – 1598ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATPase activity Source: UniProtKB
    2. ATP binding Source: UniProtKB-KW
    3. microtubule motor activity Source: InterPro
    4. WW domain binding Source: UniProtKB

    GO - Biological processi

    1. ATP catabolic process Source: GOC
    2. cell cycle arrest Source: UniProtKB
    3. microtubule-based movement Source: InterPro
    4. mitotic M phase Source: ProtInc
    5. mitotic nuclear division Source: UniProtKB-KW
    6. regulation of mitosis Source: UniProtKB

    Keywords - Molecular functioni

    Motor protein

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Kinesin-like protein KIF20B
    Alternative name(s):
    Cancer/testis antigen 90
    Short name:
    CT90
    Kinesin-related motor interacting with PIN1
    M-phase phosphoprotein 1
    Short name:
    MPP1
    Gene namesi
    Name:KIF20B
    Synonyms:KRMP1, MPHOSPH1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:7212. KIF20B.

    Subcellular locationi

    Cytoplasm. Nucleus. Cytoplasmcytoskeletonspindle
    Note: Localizes mainly in the nucleus during interphase although it is also detected in the cytoplasm without clear association with microtubules. A 2-3 fold expression increase is seen as cells progress from G1 to G2/M phase. During prophase and metaphase it is found throughout the cytoplasm and at anaphase accumulates at the midplan of the cell and forms a distinct band extending across the spindle midzone. At anaphase it is concentrated in the mid-body.

    GO - Cellular componenti

    1. centrosome Source: UniProtKB
    2. cytoplasm Source: HPA
    3. microtubule Source: UniProtKB-KW
    4. nucleolus Source: UniProtKB
    5. nucleoplasm Source: UniProtKB
    6. nucleus Source: HPA
    7. spindle Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Microtubule, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162393285.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 18201820Kinesin-like protein KIF20BPRO_0000274053Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei488 – 4881Phosphoserine1 Publication
    Modified residuei997 – 9971PhosphoserineBy similarity
    Modified residuei1644 – 16441Phosphothreonine; by CDK11 Publication
    Modified residuei1658 – 16581Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ96Q89.
    PaxDbiQ96Q89.
    PRIDEiQ96Q89.

    PTM databases

    PhosphoSiteiQ96Q89.

    Expressioni

    Tissue specificityi

    Brain, ovary, kidney and testis.1 Publication

    Gene expression databases

    ArrayExpressiQ96Q89.
    BgeeiQ96Q89.
    GenevestigatoriQ96Q89.

    Organism-specific databases

    HPAiHPA031263.
    HPA050214.

    Interactioni

    Subunit structurei

    Interacts with PIN1.1 Publication

    Protein-protein interaction databases

    BioGridi114953. 5 interactions.
    DIPiDIP-103N.
    IntActiQ96Q89. 5 interactions.
    MINTiMINT-4712270.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96Q89.
    SMRiQ96Q89. Positions 56-487.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini58 – 479422Kinesin motorPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1560 – 1820261Interaction with PIN1Add
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili523 – 60381Sequence AnalysisAdd
    BLAST
    Coiled coili674 – 793120Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1247 – 12515Poly-Glu

    Sequence similaritiesi

    Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation
    Contains 1 kinesin motor domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG5059.
    HOVERGENiHBG106760.
    InParanoidiQ96Q89.
    KOiK10402.
    OrthoDBiEOG7TTQ73.
    PhylomeDBiQ96Q89.
    TreeFamiTF105232.

    Family and domain databases

    Gene3Di3.40.850.10. 2 hits.
    InterProiIPR028828. KIF20B.
    IPR019821. Kinesin_motor_CS.
    IPR001752. Kinesin_motor_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PANTHERiPTHR23165. PTHR23165. 1 hit.
    PfamiPF00225. Kinesin. 1 hit.
    [Graphical view]
    PRINTSiPR00380. KINESINHEAVY.
    SMARTiSM00129. KISc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 2 hits.
    PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
    PS50067. KINESIN_MOTOR_2. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96Q89-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MESNFNQEGV PRPSYVFSAD PIARPSEINF DGIKLDLSHE FSLVAPNTEA     50
    NSFESKDYLQ VCLRIRPFTQ SEKELESEGC VHILDSQTVV LKEPQCILGR 100
    LSEKSSGQMA QKFSFSKVFG PATTQKEFFQ GCIMQPVKDL LKGQSRLIFT 150
    YGLTNSGKTY TFQGTEENIG ILPRTLNVLF DSLQERLYTK MNLKPHRSRE 200
    YLRLSSEQEK EEIASKSALL RQIKEVTVHN DSDDTLYGSL TNSLNISEFE 250
    ESIKDYEQAN LNMANSIKFS VWVSFFEIYN EYIYDLFVPV SSKFQKRKML 300
    RLSQDVKGYS FIKDLQWIQV SDSKEAYRLL KLGIKHQSVA FTKLNNASSR 350
    SHSIFTVKIL QIEDSEMSRV IRVSELSLCD LAGSERTMKT QNEGERLRET 400
    GNINTSLLTL GKCINVLKNS EKSKFQQHVP FRESKLTHYF QSFFNGKGKI 450
    CMIVNISQCY LAYDETLNVL KFSAIAQKVC VPDTLNSSQE KLFGPVKSSQ 500
    DVSLDSNSNS KILNVKRATI SWENSLEDLM EDEDLVEELE NAEETQNVET 550
    KLLDEDLDKT LEENKAFISH EEKRKLLDLI EDLKKKLINE KKEKLTLEFK 600
    IREEVTQEFT QYWAQREADF KETLLQEREI LEENAERRLA IFKDLVGKCD 650
    TREEAAKDIC ATKVETEETH NYVGFEDIID SLQDNVADIK KQAEIAHLYI 700
    ASLPDPQEAT ACLELKFNQI KAELAKTKGE LIKTKEELKK RENESDSLIQ 750
    ELETSNKKII TQNQRIKELI NIIDQKEDTI NEFQNLKSHM ENTFKCNDKA 800
    DTSSLIINNK LICNETVEVP KDSKSKICSE RKRVNENELQ QDEPPAKKGS 850
    IHVSSAITED QKKSEEVRPN IAEIEDIRVL QENNEGLRAF LLTIENELKN 900
    EKEEKAELNK QIVHFQQELS LSEKKNLTLS KEVQQIQSNY DIAIAELHVQ 950
    KSKNQEQEEK IMKLSNEIET ATRSITNNVS QIKLMHTKID ELRTLDSVSQ 1000
    ISNIDLLNLR DLSNGSEEDN LPNTQLDLLG NDYLVSKQVK EYRIQEPNRE 1050
    NSFHSSIEAI WEECKEIVKA SSKKSHQIEE LEQQIEKLQA EVKGYKDENN 1100
    RLKEKEHKNQ DDLLKEKETL IQQLKEELQE KNVTLDVQIQ HVVEGKRALS 1150
    ELTQGVTCYK AKIKELETIL ETQKVECSHS AKLEQDILEK ESIILKLERN 1200
    LKEFQEHLQD SVKNTKDLNV KELKLKEEIT QLTNNLQDMK HLLQLKEEEE 1250
    ETNRQETEKL KEELSASSAR TQNLKADLQR KEEDYADLKE KLTDAKKQIK 1300
    QVQKEVSVMR DEDKLLRIKI NELEKKKNQC SQELDMKQRT IQQLKEQLNN 1350
    QKVEEAIQQY ERACKDLNVK EKIIEDMRMT LEEQEQTQVE QDQVLEAKLE 1400
    EVERLATELE KWKEKCNDLE TKNNQRSNKE HENNTDVLGK LTNLQDELQE 1450
    SEQKYNADRK KWLEEKMMLI TQAKEAENIR NKEMKKYAED RERFFKQQNE 1500
    MEILTAQLTE KDSDLQKWRE ERDQLVAALE IQLKALISSN VQKDNEIEQL 1550
    KRIISETSKI ETQIMDIKPK RISSADPDKL QTEPLSTSFE ISRNKIEDGS 1600
    VVLDSCEVST ENDQSTRFPK PELEIQFTPL QPNKMAVKHP GCTTPVTVKI 1650
    PKARKRKSNE MEEDLVKCEN KKNATPRTNL KFPISDDRNS SVKKEQKVAI 1700
    RPSSKKTYSL RSQASIIGVN LATKKKEGTL QKFGDFLQHS PSILQSKAKK 1750
    IIETMSSSKL SNVEASKENV SQPKRAKRKL YTSEISSPID ISGQVILMDQ 1800
    KMKESDHQII KRRLRTKTAK 1820
    Length:1,820
    Mass (Da):210,629
    Last modified:October 5, 2010 - v3
    Checksum:i8A6FE95A6F3BA20C
    GO
    Isoform 2 (identifier: Q96Q89-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         849-849: G → GTTSAASSRRLRKLISKPKKGVNRTRQTEGHSLV

    Show »
    Length:1,853
    Mass (Da):214,276
    Checksum:i07E7FFF9A7D116C5
    GO
    Isoform 3 (identifier: Q96Q89-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         668-707: Missing.

    Show »
    Length:1,780
    Mass (Da):206,136
    Checksum:i084B8D31404946E4
    GO
    Isoform 4 (identifier: Q96Q89-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1664-1722: DLVKCENKKN...QASIIGVNLA → SASPPPKECS...EVENFEKNLD
         1723-1820: Missing.

    Show »
    Length:1,722
    Mass (Da):199,810
    Checksum:i6B5B4801B38BFF40
    GO
    Isoform 5 (identifier: Q96Q89-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1308: Missing.

    Show »
    Length:512
    Mass (Da):59,621
    Checksum:i15D67C1B5D1FBD7B
    GO

    Sequence cautioni

    The sequence AAH46134.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
    The sequence AAH58913.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
    The sequence AAH93089.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
    The sequence AAI08689.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
    The sequence BAB15043.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
    The sequence CAI12885.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAI16829.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti266 – 2661S → T in BAB69456. (PubMed:11470801)Curated
    Sequence conflicti296 – 2972KR → NT in BAB69456. (PubMed:11470801)Curated
    Sequence conflicti357 – 3571V → I in BAB69456. (PubMed:11470801)Curated
    Sequence conflicti388 – 3881M → V in BAB69456. (PubMed:11470801)Curated
    Sequence conflicti593 – 5931E → K in AAI08689. (PubMed:15489334)Curated
    Sequence conflicti705 – 7073DPQ → ETE in AAP40331. (PubMed:12740395)Curated
    Sequence conflicti753 – 7531E → K in BAB69456. (PubMed:11470801)Curated
    Sequence conflicti797 – 7971N → S in BAB15043. (PubMed:14702039)Curated
    Sequence conflicti870 – 8701N → S in BAB15043. (PubMed:14702039)Curated
    Sequence conflicti915 – 9151F → S in BAB15043. (PubMed:14702039)Curated
    Sequence conflicti1105 – 11051K → R in BAB15043. (PubMed:14702039)Curated
    Sequence conflicti1302 – 13021V → E in AAC37542. (PubMed:8290587)Curated
    Sequence conflicti1459 – 14591R → S in AAC37542. (PubMed:8290587)Curated
    Sequence conflicti1608 – 16081V → A in BAB69456. (PubMed:11470801)Curated
    Sequence conflicti1649 – 16491K → E in CAB55962. (PubMed:11230166)Curated
    Sequence conflicti1649 – 16491K → E in BAB15194. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti50 – 501A → G.
    Corresponds to variant rs1129777 [ dbSNP | Ensembl ].
    VAR_030181
    Natural varianti490 – 4901E → D.2 Publications
    Corresponds to variant rs17484219 [ dbSNP | Ensembl ].
    VAR_030182
    Natural varianti756 – 7561N → I.2 Publications
    Corresponds to variant rs12572012 [ dbSNP | Ensembl ].
    VAR_030183
    Natural varianti789 – 7891H → L.2 Publications
    Corresponds to variant rs3758388 [ dbSNP | Ensembl ].
    VAR_030184
    Natural varianti1011 – 10111D → E.
    Corresponds to variant rs1062465 [ dbSNP | Ensembl ].
    VAR_030185
    Natural varianti1127 – 11271E → Q.
    Corresponds to variant rs11185863 [ dbSNP | Ensembl ].
    VAR_030186
    Natural varianti1177 – 11771C → R.6 Publications
    Corresponds to variant rs1886996 [ dbSNP | Ensembl ].
    VAR_030187
    Natural varianti1219 – 12191N → S.
    Corresponds to variant rs1886997 [ dbSNP | Ensembl ].
    VAR_030188
    Natural varianti1789 – 17891I → V.
    Corresponds to variant rs3758390 [ dbSNP | Ensembl ].
    VAR_030189

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 13081308Missing in isoform 5. 1 PublicationVSP_022618Add
    BLAST
    Alternative sequencei668 – 70740Missing in isoform 3. 4 PublicationsVSP_022619Add
    BLAST
    Alternative sequencei849 – 8491G → GTTSAASSRRLRKLISKPKK GVNRTRQTEGHSLV in isoform 2. 1 PublicationVSP_022620
    Alternative sequencei1664 – 172259DLVKC…GVNLA → SASPPPKECSSSPAMEQSWK ENDFDKLREEGFRRSNYSEL QEEIQTKGKEVENFEKNLD in isoform 4. 1 PublicationVSP_022621Add
    BLAST
    Alternative sequencei1723 – 182098Missing in isoform 4. 1 PublicationVSP_022622Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB033337 mRNA. Translation: BAB69456.1.
    AB033338 mRNA. Translation: BAB20417.1.
    AL117496 mRNA. Translation: CAB55962.1.
    AK024959 mRNA. Translation: BAB15043.1. Sequence problems.
    AK025628 mRNA. Translation: BAB15194.1.
    AL157389, AL157400 Genomic DNA. Translation: CAI12885.1. Sequence problems.
    AL157389, AL157400 Genomic DNA. Translation: CAI12886.1.
    AL157389, AL157400 Genomic DNA. Translation: CAI12887.1.
    AL157400, AL157389 Genomic DNA. Translation: CAI16829.1. Sequence problems.
    AL157400, AL157389 Genomic DNA. Translation: CAI16830.1.
    AL157400, AL157389 Genomic DNA. Translation: CAI16831.1.
    AL157400 Genomic DNA. Translation: CAI16832.1.
    AY282406 mRNA. Translation: AAP40330.1.
    AY282407 mRNA. Translation: AAP40331.1.
    BC046134 mRNA. Translation: AAH46134.1. Sequence problems.
    BC058913 mRNA. Translation: AAH58913.1. Sequence problems.
    BC093089 mRNA. Translation: AAH93089.1. Sequence problems.
    BC108688 mRNA. Translation: AAI08689.1. Sequence problems.
    AL137392 mRNA. Translation: CAB70720.1.
    U93121 mRNA. Translation: AAB88727.1.
    AY739715 mRNA. Translation: AAW65984.1.
    L16782 mRNA. Translation: AAC37542.1.
    CCDSiCCDS60590.1. [Q96Q89-1]
    CCDS7407.1. [Q96Q89-3]
    PIRiT17272.
    RefSeqiNP_001271188.1. NM_001284259.1. [Q96Q89-1]
    NP_057279.2. NM_016195.3. [Q96Q89-3]
    UniGeneiHs.240.

    Genome annotation databases

    EnsembliENST00000260753; ENSP00000260753; ENSG00000138182. [Q96Q89-3]
    ENST00000371728; ENSP00000360793; ENSG00000138182. [Q96Q89-1]
    GeneIDi9585.
    KEGGihsa:9585.
    UCSCiuc001kgr.1. human. [Q96Q89-3]
    uc001kgs.1. human. [Q96Q89-1]

    Polymorphism databases

    DMDMi308153587.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB033337 mRNA. Translation: BAB69456.1 .
    AB033338 mRNA. Translation: BAB20417.1 .
    AL117496 mRNA. Translation: CAB55962.1 .
    AK024959 mRNA. Translation: BAB15043.1 . Sequence problems.
    AK025628 mRNA. Translation: BAB15194.1 .
    AL157389 , AL157400 Genomic DNA. Translation: CAI12885.1 . Sequence problems.
    AL157389 , AL157400 Genomic DNA. Translation: CAI12886.1 .
    AL157389 , AL157400 Genomic DNA. Translation: CAI12887.1 .
    AL157400 , AL157389 Genomic DNA. Translation: CAI16829.1 . Sequence problems.
    AL157400 , AL157389 Genomic DNA. Translation: CAI16830.1 .
    AL157400 , AL157389 Genomic DNA. Translation: CAI16831.1 .
    AL157400 Genomic DNA. Translation: CAI16832.1 .
    AY282406 mRNA. Translation: AAP40330.1 .
    AY282407 mRNA. Translation: AAP40331.1 .
    BC046134 mRNA. Translation: AAH46134.1 . Sequence problems.
    BC058913 mRNA. Translation: AAH58913.1 . Sequence problems.
    BC093089 mRNA. Translation: AAH93089.1 . Sequence problems.
    BC108688 mRNA. Translation: AAI08689.1 . Sequence problems.
    AL137392 mRNA. Translation: CAB70720.1 .
    U93121 mRNA. Translation: AAB88727.1 .
    AY739715 mRNA. Translation: AAW65984.1 .
    L16782 mRNA. Translation: AAC37542.1 .
    CCDSi CCDS60590.1. [Q96Q89-1 ]
    CCDS7407.1. [Q96Q89-3 ]
    PIRi T17272.
    RefSeqi NP_001271188.1. NM_001284259.1. [Q96Q89-1 ]
    NP_057279.2. NM_016195.3. [Q96Q89-3 ]
    UniGenei Hs.240.

    3D structure databases

    ProteinModelPortali Q96Q89.
    SMRi Q96Q89. Positions 56-487.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114953. 5 interactions.
    DIPi DIP-103N.
    IntActi Q96Q89. 5 interactions.
    MINTi MINT-4712270.

    Chemistry

    ChEMBLi CHEMBL2021752.

    PTM databases

    PhosphoSitei Q96Q89.

    Polymorphism databases

    DMDMi 308153587.

    Proteomic databases

    MaxQBi Q96Q89.
    PaxDbi Q96Q89.
    PRIDEi Q96Q89.

    Protocols and materials databases

    DNASUi 9585.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000260753 ; ENSP00000260753 ; ENSG00000138182 . [Q96Q89-3 ]
    ENST00000371728 ; ENSP00000360793 ; ENSG00000138182 . [Q96Q89-1 ]
    GeneIDi 9585.
    KEGGi hsa:9585.
    UCSCi uc001kgr.1. human. [Q96Q89-3 ]
    uc001kgs.1. human. [Q96Q89-1 ]

    Organism-specific databases

    CTDi 9585.
    GeneCardsi GC10P091452.
    HGNCi HGNC:7212. KIF20B.
    HPAi HPA031263.
    HPA050214.
    MIMi 605498. gene.
    neXtProti NX_Q96Q89.
    PharmGKBi PA162393285.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5059.
    HOVERGENi HBG106760.
    InParanoidi Q96Q89.
    KOi K10402.
    OrthoDBi EOG7TTQ73.
    PhylomeDBi Q96Q89.
    TreeFami TF105232.

    Miscellaneous databases

    ChiTaRSi KIF20B. human.
    GeneWikii MPHOSPH1.
    GenomeRNAii 9585.
    NextBioi 35959.
    PROi Q96Q89.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96Q89.
    Bgeei Q96Q89.
    Genevestigatori Q96Q89.

    Family and domain databases

    Gene3Di 3.40.850.10. 2 hits.
    InterProi IPR028828. KIF20B.
    IPR019821. Kinesin_motor_CS.
    IPR001752. Kinesin_motor_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    PANTHERi PTHR23165. PTHR23165. 1 hit.
    Pfami PF00225. Kinesin. 1 hit.
    [Graphical view ]
    PRINTSi PR00380. KINESINHEAVY.
    SMARTi SM00129. KISc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 2 hits.
    PROSITEi PS00411. KINESIN_MOTOR_1. 1 hit.
    PS50067. KINESIN_MOTOR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a novel kinesin-related protein, KRMP1, as a target for mitotic peptidyl-prolyl isomerase Pin1."
      Kamimoto T., Zama T., Aoki R., Muro Y., Hagiwara M.
      J. Biol. Chem. 276:37520-37528(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), SUBCELLULAR LOCATION, INTERACTION WITH PIN1, PHOSPHORYLATION AT THR-1644, VARIANTS ILE-756; LEU-789 AND ARG-1177.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANTS ASP-490 AND ARG-1177.
      Tissue: Testis.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 779-1480 (ISOFORMS 1/2/3/4), VARIANT ARG-1177.
      Tissue: Colon.
    4. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "M phase phosphoprotein 1 is a human plus-end-directed kinesin-related protein required for cytokinesis."
      Abaza A., Soleilhac J.-M., Westendorf J., Piel M., Crevel I., Roux A., Pirollet F.
      J. Biol. Chem. 278:27844-27852(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-957 (ISOFORM 3), NUCLEOTIDE SEQUENCE [MRNA] OF 705-1820 (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, VARIANTS ILE-756; LEU-789 AND ARG-1177.
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-740 (ISOFORM 3), VARIANT ASP-490.
      Tissue: Lung, Lymph and Testis.
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 575-1820 (ISOFORM 3).
      Tissue: Testis.
    8. "Autoantibodies from patients with idiopathic ataxia bind to M-phase phosphoprotein-1 (MPP1)."
      Fritzler M.J., Kerfoot S.M., Feasby T.E., Zochodne D.W., Westendorf J.M., Dalmau J.O., Chan E.K.
      J. Invest. Med. 48:28-39(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1068-1820 (ISOFORMS 1/2/3), VARIANT ARG-1177.
    9. "Anti-leukemia-specific humoral immune response in children with T-lineage acute lymphoblastic leukemia."
      Dohnal A.M., Panzer-Gruemayer R.E.
      Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1106-1820 (ISOFORM 4), VARIANT ARG-1177.
    10. "Cloning of cDNAs for M-phase phosphoproteins recognized by the MPM2 monoclonal antibody and determination of the phosphorylated epitope."
      Westendorf J.M., Rao P.N., Gerace L.
      Proc. Natl. Acad. Sci. U.S.A. 91:714-718(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1255-1820 (ISOFORMS 1/2/3).
    11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-488, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic kidney.
    12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1658, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiKI20B_HUMAN
    AccessioniPrimary (citable) accession number: Q96Q89
    Secondary accession number(s): A8MXM7
    , O43277, Q09471, Q2KQ73, Q32NE1, Q561V3, Q58EX8, Q5T9M8, Q5T9M9, Q5T9N0, Q5T9N1, Q7KZ68, Q7Z5E0, Q7Z5E1, Q7Z6M9, Q86X82, Q9H3R8, Q9H6Q9, Q9H755, Q9NTC1, Q9UFR5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2007
    Last sequence update: October 5, 2010
    Last modified: October 1, 2014
    This is version 102 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3