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Protein

Kinesin-like protein KIF20B

Gene

KIF20B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plus-end-directed motor enzyme that is required for completion of cytokinesis (PubMed:11470801, PubMed:12740395). Required for proper midbody organization and abscission in polarized cortical stem cells. Plays a role in the regulation of neuronal polarization by mediating the transport of specific cargos. Participates in the mobilization of SHTN1 and in the accumulation of PIP3 in the growth cone of primary hippocampal neurons in a tubulin and actin-dependent manner. In the developing telencephalon, cooperates with SHTN1 to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in cerebral cortex growth (By similarity). Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436).By similarity3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi152 – 159ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATPase activity Source: UniProtKB
  • ATP binding Source: UniProtKB-KW
  • ATP-dependent microtubule motor activity, plus-end-directed Source: UniProtKB
  • microtubule binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • WW domain binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionMotor protein
Biological processCell cycle, Cell division, Mitosis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-983189 Kinesins

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF20BCurated
Alternative name(s):
Cancer/testis antigen 90
Short name:
CT90
Kinesin family member 20BImported
Kinesin-related motor interacting with PIN11 Publication
M-phase phosphoprotein 11 Publication
Short name:
MPP11 Publication
Gene namesi
Name:KIF20BImported
Synonyms:KRMP11 Publication, MPHOSPH11 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi

Organism-specific databases

EuPathDBiHostDB:ENSG00000138182.14
HGNCiHGNC:7212 KIF20B
MIMi605498 gene
neXtProtiNX_Q96Q89

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Microtubule, Nucleus

Pathology & Biotechi

Keywords - Diseasei

Oncogene

Organism-specific databases

DisGeNETi9585
OpenTargetsiENSG00000138182
PharmGKBiPA162393285

Chemistry databases

ChEMBLiCHEMBL2021752

Polymorphism and mutation databases

BioMutaiKIF20B
DMDMi308153587

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002740531 – 1820Kinesin-like protein KIF20BAdd BLAST1820

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei488PhosphoserineCombined sources1
Modified residuei560PhosphothreonineCombined sources1
Modified residuei997PhosphoserineBy similarity1
Modified residuei1588PhosphoserineCombined sources1
Modified residuei1644Phosphothreonine; by CDK11 Publication1
Modified residuei1658PhosphoserineCombined sources1
Modified residuei1715PhosphoserineCombined sources1
Modified residuei1740PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated during mitosis by CDK1 (PubMed:11470801, PubMed:12740395).2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96Q89
MaxQBiQ96Q89
PaxDbiQ96Q89
PeptideAtlasiQ96Q89
PRIDEiQ96Q89

PTM databases

CarbonylDBiQ96Q89
iPTMnetiQ96Q89
PhosphoSitePlusiQ96Q89

Expressioni

Tissue specificityi

Brain, ovary, kidney and testis (at protein level) (PubMed:12740395). Overexpressed in bladder cancer cells (at protein level) (PubMed:17409436). Expressed in testis. Overexpressed in bladder cancer cells (PubMed:17409436).2 Publications

Gene expression databases

BgeeiENSG00000138182
ExpressionAtlasiQ96Q89 baseline and differential
GenevisibleiQ96Q89 HS

Organism-specific databases

HPAiHPA031263
HPA050214

Interactioni

Subunit structurei

Oligomerizes (via kinesin motor domain) (PubMed:11470801). Associates with microtubules (PubMed:12740395). Interacts (via C-terminal globular tail region) with PIN1 (via WW domain) (PubMed:11470801). Interacts with PRC1 (PubMed:17409436). Interacts with SHTN1 (via N-terminus); the interaction is direct and promotes the association of SHTN1 to microtubules in primary neurons.By similarity3 Publications

GO - Molecular functioni

  • microtubule binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • WW domain binding Source: UniProtKB

Protein-protein interaction databases

BioGridi114953, 28 interactors
DIPiDIP-103N
IntActiQ96Q89, 19 interactors
STRINGi9606.ENSP00000260753

Structurei

3D structure databases

ProteinModelPortaliQ96Q89
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini58 – 479Kinesin motorPROSITE-ProRule annotationAdd BLAST422

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1050 – 1107Necessary and sufficient for interaction with SHTN1By similarityAdd BLAST58
Regioni1560 – 1820Interaction with PIN11 PublicationAdd BLAST261

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili523 – 603Sequence analysisAdd BLAST81
Coiled coili674 – 793Sequence analysisAdd BLAST120

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1247 – 1251Poly-Glu5

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0247 Eukaryota
COG5059 LUCA
GeneTreeiENSGT00870000136438
HOVERGENiHBG106760
InParanoidiQ96Q89
KOiK10402
OMAiGIKHQSV
OrthoDBiEOG091G00AY
PhylomeDBiQ96Q89
TreeFamiTF105232

Family and domain databases

Gene3Di3.40.850.10, 2 hits
InterProiView protein in InterPro
IPR028828 KIF20B
IPR027640 Kinesin-like_fam
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
PANTHERiPTHR24115 PTHR24115, 4 hits
PTHR24115:SF534 PTHR24115:SF534, 4 hits
PfamiView protein in Pfam
PF00225 Kinesin, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00129 KISc, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96Q89-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESNFNQEGV PRPSYVFSAD PIARPSEINF DGIKLDLSHE FSLVAPNTEA
60 70 80 90 100
NSFESKDYLQ VCLRIRPFTQ SEKELESEGC VHILDSQTVV LKEPQCILGR
110 120 130 140 150
LSEKSSGQMA QKFSFSKVFG PATTQKEFFQ GCIMQPVKDL LKGQSRLIFT
160 170 180 190 200
YGLTNSGKTY TFQGTEENIG ILPRTLNVLF DSLQERLYTK MNLKPHRSRE
210 220 230 240 250
YLRLSSEQEK EEIASKSALL RQIKEVTVHN DSDDTLYGSL TNSLNISEFE
260 270 280 290 300
ESIKDYEQAN LNMANSIKFS VWVSFFEIYN EYIYDLFVPV SSKFQKRKML
310 320 330 340 350
RLSQDVKGYS FIKDLQWIQV SDSKEAYRLL KLGIKHQSVA FTKLNNASSR
360 370 380 390 400
SHSIFTVKIL QIEDSEMSRV IRVSELSLCD LAGSERTMKT QNEGERLRET
410 420 430 440 450
GNINTSLLTL GKCINVLKNS EKSKFQQHVP FRESKLTHYF QSFFNGKGKI
460 470 480 490 500
CMIVNISQCY LAYDETLNVL KFSAIAQKVC VPDTLNSSQE KLFGPVKSSQ
510 520 530 540 550
DVSLDSNSNS KILNVKRATI SWENSLEDLM EDEDLVEELE NAEETQNVET
560 570 580 590 600
KLLDEDLDKT LEENKAFISH EEKRKLLDLI EDLKKKLINE KKEKLTLEFK
610 620 630 640 650
IREEVTQEFT QYWAQREADF KETLLQEREI LEENAERRLA IFKDLVGKCD
660 670 680 690 700
TREEAAKDIC ATKVETEETH NYVGFEDIID SLQDNVADIK KQAEIAHLYI
710 720 730 740 750
ASLPDPQEAT ACLELKFNQI KAELAKTKGE LIKTKEELKK RENESDSLIQ
760 770 780 790 800
ELETSNKKII TQNQRIKELI NIIDQKEDTI NEFQNLKSHM ENTFKCNDKA
810 820 830 840 850
DTSSLIINNK LICNETVEVP KDSKSKICSE RKRVNENELQ QDEPPAKKGS
860 870 880 890 900
IHVSSAITED QKKSEEVRPN IAEIEDIRVL QENNEGLRAF LLTIENELKN
910 920 930 940 950
EKEEKAELNK QIVHFQQELS LSEKKNLTLS KEVQQIQSNY DIAIAELHVQ
960 970 980 990 1000
KSKNQEQEEK IMKLSNEIET ATRSITNNVS QIKLMHTKID ELRTLDSVSQ
1010 1020 1030 1040 1050
ISNIDLLNLR DLSNGSEEDN LPNTQLDLLG NDYLVSKQVK EYRIQEPNRE
1060 1070 1080 1090 1100
NSFHSSIEAI WEECKEIVKA SSKKSHQIEE LEQQIEKLQA EVKGYKDENN
1110 1120 1130 1140 1150
RLKEKEHKNQ DDLLKEKETL IQQLKEELQE KNVTLDVQIQ HVVEGKRALS
1160 1170 1180 1190 1200
ELTQGVTCYK AKIKELETIL ETQKVECSHS AKLEQDILEK ESIILKLERN
1210 1220 1230 1240 1250
LKEFQEHLQD SVKNTKDLNV KELKLKEEIT QLTNNLQDMK HLLQLKEEEE
1260 1270 1280 1290 1300
ETNRQETEKL KEELSASSAR TQNLKADLQR KEEDYADLKE KLTDAKKQIK
1310 1320 1330 1340 1350
QVQKEVSVMR DEDKLLRIKI NELEKKKNQC SQELDMKQRT IQQLKEQLNN
1360 1370 1380 1390 1400
QKVEEAIQQY ERACKDLNVK EKIIEDMRMT LEEQEQTQVE QDQVLEAKLE
1410 1420 1430 1440 1450
EVERLATELE KWKEKCNDLE TKNNQRSNKE HENNTDVLGK LTNLQDELQE
1460 1470 1480 1490 1500
SEQKYNADRK KWLEEKMMLI TQAKEAENIR NKEMKKYAED RERFFKQQNE
1510 1520 1530 1540 1550
MEILTAQLTE KDSDLQKWRE ERDQLVAALE IQLKALISSN VQKDNEIEQL
1560 1570 1580 1590 1600
KRIISETSKI ETQIMDIKPK RISSADPDKL QTEPLSTSFE ISRNKIEDGS
1610 1620 1630 1640 1650
VVLDSCEVST ENDQSTRFPK PELEIQFTPL QPNKMAVKHP GCTTPVTVKI
1660 1670 1680 1690 1700
PKARKRKSNE MEEDLVKCEN KKNATPRTNL KFPISDDRNS SVKKEQKVAI
1710 1720 1730 1740 1750
RPSSKKTYSL RSQASIIGVN LATKKKEGTL QKFGDFLQHS PSILQSKAKK
1760 1770 1780 1790 1800
IIETMSSSKL SNVEASKENV SQPKRAKRKL YTSEISSPID ISGQVILMDQ
1810 1820
KMKESDHQII KRRLRTKTAK
Length:1,820
Mass (Da):210,629
Last modified:October 5, 2010 - v3
Checksum:i8A6FE95A6F3BA20C
GO
Isoform 2 (identifier: Q96Q89-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     849-849: G → GTTSAASSRRLRKLISKPKKGVNRTRQTEGHSLV

Show »
Length:1,853
Mass (Da):214,276
Checksum:i07E7FFF9A7D116C5
GO
Isoform 3 (identifier: Q96Q89-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     668-707: Missing.

Show »
Length:1,780
Mass (Da):206,136
Checksum:i084B8D31404946E4
GO
Isoform 4 (identifier: Q96Q89-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1664-1722: DLVKCENKKN...QASIIGVNLA → SASPPPKECS...EVENFEKNLD
     1723-1820: Missing.

Show »
Length:1,722
Mass (Da):199,810
Checksum:i6B5B4801B38BFF40
GO
Isoform 5 (identifier: Q96Q89-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1308: Missing.

Show »
Length:512
Mass (Da):59,621
Checksum:i15D67C1B5D1FBD7B
GO

Sequence cautioni

The sequence AAH46134 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH58913 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH93089 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAI08689 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAB15043 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence CAI12885 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI16829 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti266S → T in BAB69456 (PubMed:11470801).Curated1
Sequence conflicti296 – 297KR → NT in BAB69456 (PubMed:11470801).Curated2
Sequence conflicti357V → I in BAB69456 (PubMed:11470801).Curated1
Sequence conflicti388M → V in BAB69456 (PubMed:11470801).Curated1
Sequence conflicti593E → K in AAI08689 (PubMed:15489334).Curated1
Sequence conflicti705 – 707DPQ → ETE in AAP40331 (PubMed:12740395).Curated3
Sequence conflicti753E → K in BAB69456 (PubMed:11470801).Curated1
Sequence conflicti797N → S in BAB15043 (PubMed:14702039).Curated1
Sequence conflicti870N → S in BAB15043 (PubMed:14702039).Curated1
Sequence conflicti915F → S in BAB15043 (PubMed:14702039).Curated1
Sequence conflicti1105K → R in BAB15043 (PubMed:14702039).Curated1
Sequence conflicti1302V → E in AAC37542 (PubMed:8290587).Curated1
Sequence conflicti1459R → S in AAC37542 (PubMed:8290587).Curated1
Sequence conflicti1608V → A in BAB69456 (PubMed:11470801).Curated1
Sequence conflicti1649K → E in CAB55962 (PubMed:11230166).Curated1
Sequence conflicti1649K → E in BAB15194 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03018150A → G. Corresponds to variant dbSNP:rs1129777Ensembl.1
Natural variantiVAR_030182490E → D2 PublicationsCorresponds to variant dbSNP:rs17484219Ensembl.1
Natural variantiVAR_030183756N → I2 PublicationsCorresponds to variant dbSNP:rs12572012Ensembl.1
Natural variantiVAR_030184789H → L2 PublicationsCorresponds to variant dbSNP:rs3758388Ensembl.1
Natural variantiVAR_0301851011D → E. Corresponds to variant dbSNP:rs1062465Ensembl.1
Natural variantiVAR_0301861127E → Q. Corresponds to variant dbSNP:rs11185863Ensembl.1
Natural variantiVAR_0757041148A → V1 PublicationCorresponds to variant dbSNP:rs117564945Ensembl.1
Natural variantiVAR_0301871177C → R6 PublicationsCorresponds to variant dbSNP:rs1886996Ensembl.1
Natural variantiVAR_0301881219N → S. Corresponds to variant dbSNP:rs1886997Ensembl.1
Natural variantiVAR_0757051589F → Y1 PublicationCorresponds to variant dbSNP:rs117258675Ensembl.1
Natural variantiVAR_0301891789I → V. Corresponds to variant dbSNP:rs3758390Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0226181 – 1308Missing in isoform 5. 1 PublicationAdd BLAST1308
Alternative sequenceiVSP_022619668 – 707Missing in isoform 3. 4 PublicationsAdd BLAST40
Alternative sequenceiVSP_022620849G → GTTSAASSRRLRKLISKPKK GVNRTRQTEGHSLV in isoform 2. 1 Publication1
Alternative sequenceiVSP_0226211664 – 1722DLVKC…GVNLA → SASPPPKECSSSPAMEQSWK ENDFDKLREEGFRRSNYSEL QEEIQTKGKEVENFEKNLD in isoform 4. 1 PublicationAdd BLAST59
Alternative sequenceiVSP_0226221723 – 1820Missing in isoform 4. 1 PublicationAdd BLAST98

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033337 mRNA Translation: BAB69456.1
AB033338 mRNA Translation: BAB20417.1
AL117496 mRNA Translation: CAB55962.1
AK024959 mRNA Translation: BAB15043.1 Sequence problems.
AK025628 mRNA Translation: BAB15194.1
AL157389, AL157400 Genomic DNA Translation: CAI12885.1 Sequence problems.
AL157389, AL157400 Genomic DNA Translation: CAI12886.1
AL157389, AL157400 Genomic DNA Translation: CAI12887.1
AL157400, AL157389 Genomic DNA Translation: CAI16829.1 Sequence problems.
AL157400, AL157389 Genomic DNA Translation: CAI16830.1
AL157400, AL157389 Genomic DNA Translation: CAI16831.1
AL157400 Genomic DNA Translation: CAI16832.1
AY282406 mRNA Translation: AAP40330.1
AY282407 mRNA Translation: AAP40331.1
BC046134 mRNA Translation: AAH46134.1 Sequence problems.
BC058913 mRNA Translation: AAH58913.1 Sequence problems.
BC093089 mRNA Translation: AAH93089.1 Sequence problems.
BC108688 mRNA Translation: AAI08689.1 Sequence problems.
AL137392 mRNA Translation: CAB70720.1
U93121 mRNA Translation: AAB88727.1
AY739715 mRNA Translation: AAW65984.1
L16782 mRNA Translation: AAC37542.1
CCDSiCCDS60590.1 [Q96Q89-1]
CCDS7407.1 [Q96Q89-3]
PIRiT17272
RefSeqiNP_001271188.1, NM_001284259.1 [Q96Q89-1]
NP_057279.2, NM_016195.3 [Q96Q89-3]
UniGeneiHs.240

Genome annotation databases

EnsembliENST00000260753; ENSP00000260753; ENSG00000138182 [Q96Q89-3]
ENST00000371728; ENSP00000360793; ENSG00000138182 [Q96Q89-1]
GeneIDi9585
KEGGihsa:9585
UCSCiuc001kgr.3 human [Q96Q89-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiKI20B_HUMAN
AccessioniPrimary (citable) accession number: Q96Q89
Secondary accession number(s): A8MXM7
, O43277, Q09471, Q2KQ73, Q32NE1, Q561V3, Q58EX8, Q5T9M8, Q5T9M9, Q5T9N0, Q5T9N1, Q7KZ68, Q7Z5E0, Q7Z5E1, Q7Z6M9, Q86X82, Q9H3R8, Q9H6Q9, Q9H755, Q9NTC1, Q9UFR5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: October 5, 2010
Last modified: May 23, 2018
This is version 138 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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