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Q96Q89

- KI20B_HUMAN

UniProt

Q96Q89 - KI20B_HUMAN

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Protein

Kinesin-like protein KIF20B

Gene

KIF20B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Plus-end-directed motor enzyme that is required for completion of cytokinesis.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi152 – 1598ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATPase activity Source: UniProtKB
  2. ATP binding Source: UniProtKB-KW
  3. microtubule motor activity Source: InterPro
  4. WW domain binding Source: UniProtKB

GO - Biological processi

  1. ATP catabolic process Source: GOC
  2. cell cycle arrest Source: UniProtKB
  3. microtubule-based movement Source: InterPro
  4. mitotic nuclear division Source: UniProtKB-KW
  5. neural tube closure Source: Ensembl
  6. regulation of establishment of cell polarity Source: Ensembl
  7. regulation of establishment of protein localization Source: Ensembl
  8. regulation of mitosis Source: UniProtKB
  9. regulation of neuron migration Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF20B
Alternative name(s):
Cancer/testis antigen 90
Short name:
CT90
Kinesin-related motor interacting with PIN1
M-phase phosphoprotein 1
Short name:
MPP1
Gene namesi
Name:KIF20B
Synonyms:KRMP1, MPHOSPH1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:7212. KIF20B.

Subcellular locationi

Cytoplasm. Nucleus. Cytoplasmcytoskeletonspindle
Note: Localizes mainly in the nucleus during interphase although it is also detected in the cytoplasm without clear association with microtubules. A 2-3 fold expression increase is seen as cells progress from G1 to G2/M phase. During prophase and metaphase it is found throughout the cytoplasm and at anaphase accumulates at the midplan of the cell and forms a distinct band extending across the spindle midzone. At anaphase it is concentrated in the mid-body.

GO - Cellular componenti

  1. centrosome Source: UniProtKB
  2. cytoplasm Source: UniProtKB
  3. microtubule Source: UniProtKB-KW
  4. nucleolus Source: UniProtKB
  5. nucleoplasm Source: UniProtKB
  6. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162393285.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 18201820Kinesin-like protein KIF20BPRO_0000274053Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei488 – 4881Phosphoserine1 Publication
Modified residuei997 – 9971PhosphoserineBy similarity
Modified residuei1644 – 16441Phosphothreonine; by CDK11 Publication
Modified residuei1658 – 16581Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ96Q89.
PaxDbiQ96Q89.
PRIDEiQ96Q89.

PTM databases

PhosphoSiteiQ96Q89.

Expressioni

Tissue specificityi

Brain, ovary, kidney and testis.1 Publication

Gene expression databases

BgeeiQ96Q89.
GenevestigatoriQ96Q89.

Organism-specific databases

HPAiHPA031263.
HPA050214.

Interactioni

Subunit structurei

Interacts with PIN1.1 Publication

Protein-protein interaction databases

BioGridi114953. 5 interactions.
DIPiDIP-103N.
IntActiQ96Q89. 5 interactions.
MINTiMINT-4712270.

Structurei

3D structure databases

ProteinModelPortaliQ96Q89.
SMRiQ96Q89. Positions 56-479.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini58 – 479422Kinesin motorPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1560 – 1820261Interaction with PIN1Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili523 – 60381Sequence AnalysisAdd
BLAST
Coiled coili674 – 793120Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1247 – 12515Poly-Glu

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation
Contains 1 kinesin motor domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG5059.
GeneTreeiENSGT00760000118872.
HOVERGENiHBG106760.
InParanoidiQ96Q89.
KOiK10402.
OrthoDBiEOG7TTQ73.
PhylomeDBiQ96Q89.
TreeFamiTF105232.

Family and domain databases

Gene3Di3.40.850.10. 2 hits.
InterProiIPR028828. KIF20B.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR23165. PTHR23165. 1 hit.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96Q89-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESNFNQEGV PRPSYVFSAD PIARPSEINF DGIKLDLSHE FSLVAPNTEA
60 70 80 90 100
NSFESKDYLQ VCLRIRPFTQ SEKELESEGC VHILDSQTVV LKEPQCILGR
110 120 130 140 150
LSEKSSGQMA QKFSFSKVFG PATTQKEFFQ GCIMQPVKDL LKGQSRLIFT
160 170 180 190 200
YGLTNSGKTY TFQGTEENIG ILPRTLNVLF DSLQERLYTK MNLKPHRSRE
210 220 230 240 250
YLRLSSEQEK EEIASKSALL RQIKEVTVHN DSDDTLYGSL TNSLNISEFE
260 270 280 290 300
ESIKDYEQAN LNMANSIKFS VWVSFFEIYN EYIYDLFVPV SSKFQKRKML
310 320 330 340 350
RLSQDVKGYS FIKDLQWIQV SDSKEAYRLL KLGIKHQSVA FTKLNNASSR
360 370 380 390 400
SHSIFTVKIL QIEDSEMSRV IRVSELSLCD LAGSERTMKT QNEGERLRET
410 420 430 440 450
GNINTSLLTL GKCINVLKNS EKSKFQQHVP FRESKLTHYF QSFFNGKGKI
460 470 480 490 500
CMIVNISQCY LAYDETLNVL KFSAIAQKVC VPDTLNSSQE KLFGPVKSSQ
510 520 530 540 550
DVSLDSNSNS KILNVKRATI SWENSLEDLM EDEDLVEELE NAEETQNVET
560 570 580 590 600
KLLDEDLDKT LEENKAFISH EEKRKLLDLI EDLKKKLINE KKEKLTLEFK
610 620 630 640 650
IREEVTQEFT QYWAQREADF KETLLQEREI LEENAERRLA IFKDLVGKCD
660 670 680 690 700
TREEAAKDIC ATKVETEETH NYVGFEDIID SLQDNVADIK KQAEIAHLYI
710 720 730 740 750
ASLPDPQEAT ACLELKFNQI KAELAKTKGE LIKTKEELKK RENESDSLIQ
760 770 780 790 800
ELETSNKKII TQNQRIKELI NIIDQKEDTI NEFQNLKSHM ENTFKCNDKA
810 820 830 840 850
DTSSLIINNK LICNETVEVP KDSKSKICSE RKRVNENELQ QDEPPAKKGS
860 870 880 890 900
IHVSSAITED QKKSEEVRPN IAEIEDIRVL QENNEGLRAF LLTIENELKN
910 920 930 940 950
EKEEKAELNK QIVHFQQELS LSEKKNLTLS KEVQQIQSNY DIAIAELHVQ
960 970 980 990 1000
KSKNQEQEEK IMKLSNEIET ATRSITNNVS QIKLMHTKID ELRTLDSVSQ
1010 1020 1030 1040 1050
ISNIDLLNLR DLSNGSEEDN LPNTQLDLLG NDYLVSKQVK EYRIQEPNRE
1060 1070 1080 1090 1100
NSFHSSIEAI WEECKEIVKA SSKKSHQIEE LEQQIEKLQA EVKGYKDENN
1110 1120 1130 1140 1150
RLKEKEHKNQ DDLLKEKETL IQQLKEELQE KNVTLDVQIQ HVVEGKRALS
1160 1170 1180 1190 1200
ELTQGVTCYK AKIKELETIL ETQKVECSHS AKLEQDILEK ESIILKLERN
1210 1220 1230 1240 1250
LKEFQEHLQD SVKNTKDLNV KELKLKEEIT QLTNNLQDMK HLLQLKEEEE
1260 1270 1280 1290 1300
ETNRQETEKL KEELSASSAR TQNLKADLQR KEEDYADLKE KLTDAKKQIK
1310 1320 1330 1340 1350
QVQKEVSVMR DEDKLLRIKI NELEKKKNQC SQELDMKQRT IQQLKEQLNN
1360 1370 1380 1390 1400
QKVEEAIQQY ERACKDLNVK EKIIEDMRMT LEEQEQTQVE QDQVLEAKLE
1410 1420 1430 1440 1450
EVERLATELE KWKEKCNDLE TKNNQRSNKE HENNTDVLGK LTNLQDELQE
1460 1470 1480 1490 1500
SEQKYNADRK KWLEEKMMLI TQAKEAENIR NKEMKKYAED RERFFKQQNE
1510 1520 1530 1540 1550
MEILTAQLTE KDSDLQKWRE ERDQLVAALE IQLKALISSN VQKDNEIEQL
1560 1570 1580 1590 1600
KRIISETSKI ETQIMDIKPK RISSADPDKL QTEPLSTSFE ISRNKIEDGS
1610 1620 1630 1640 1650
VVLDSCEVST ENDQSTRFPK PELEIQFTPL QPNKMAVKHP GCTTPVTVKI
1660 1670 1680 1690 1700
PKARKRKSNE MEEDLVKCEN KKNATPRTNL KFPISDDRNS SVKKEQKVAI
1710 1720 1730 1740 1750
RPSSKKTYSL RSQASIIGVN LATKKKEGTL QKFGDFLQHS PSILQSKAKK
1760 1770 1780 1790 1800
IIETMSSSKL SNVEASKENV SQPKRAKRKL YTSEISSPID ISGQVILMDQ
1810 1820
KMKESDHQII KRRLRTKTAK
Length:1,820
Mass (Da):210,629
Last modified:October 5, 2010 - v3
Checksum:i8A6FE95A6F3BA20C
GO
Isoform 2 (identifier: Q96Q89-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     849-849: G → GTTSAASSRRLRKLISKPKKGVNRTRQTEGHSLV

Show »
Length:1,853
Mass (Da):214,276
Checksum:i07E7FFF9A7D116C5
GO
Isoform 3 (identifier: Q96Q89-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     668-707: Missing.

Show »
Length:1,780
Mass (Da):206,136
Checksum:i084B8D31404946E4
GO
Isoform 4 (identifier: Q96Q89-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1664-1722: DLVKCENKKN...QASIIGVNLA → SASPPPKECS...EVENFEKNLD
     1723-1820: Missing.

Show »
Length:1,722
Mass (Da):199,810
Checksum:i6B5B4801B38BFF40
GO
Isoform 5 (identifier: Q96Q89-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1308: Missing.

Show »
Length:512
Mass (Da):59,621
Checksum:i15D67C1B5D1FBD7B
GO

Sequence cautioni

The sequence AAH46134.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
The sequence AAH58913.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
The sequence AAH93089.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
The sequence AAI08689.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
The sequence BAB15043.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
The sequence CAI12885.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence CAI16829.1 differs from that shown. Reason: Erroneous gene model prediction.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti266 – 2661S → T in BAB69456. (PubMed:11470801)Curated
Sequence conflicti296 – 2972KR → NT in BAB69456. (PubMed:11470801)Curated
Sequence conflicti357 – 3571V → I in BAB69456. (PubMed:11470801)Curated
Sequence conflicti388 – 3881M → V in BAB69456. (PubMed:11470801)Curated
Sequence conflicti593 – 5931E → K in AAI08689. (PubMed:15489334)Curated
Sequence conflicti705 – 7073DPQ → ETE in AAP40331. (PubMed:12740395)Curated
Sequence conflicti753 – 7531E → K in BAB69456. (PubMed:11470801)Curated
Sequence conflicti797 – 7971N → S in BAB15043. (PubMed:14702039)Curated
Sequence conflicti870 – 8701N → S in BAB15043. (PubMed:14702039)Curated
Sequence conflicti915 – 9151F → S in BAB15043. (PubMed:14702039)Curated
Sequence conflicti1105 – 11051K → R in BAB15043. (PubMed:14702039)Curated
Sequence conflicti1302 – 13021V → E in AAC37542. (PubMed:8290587)Curated
Sequence conflicti1459 – 14591R → S in AAC37542. (PubMed:8290587)Curated
Sequence conflicti1608 – 16081V → A in BAB69456. (PubMed:11470801)Curated
Sequence conflicti1649 – 16491K → E in CAB55962. (PubMed:11230166)Curated
Sequence conflicti1649 – 16491K → E in BAB15194. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti50 – 501A → G.
Corresponds to variant rs1129777 [ dbSNP | Ensembl ].
VAR_030181
Natural varianti490 – 4901E → D.2 Publications
Corresponds to variant rs17484219 [ dbSNP | Ensembl ].
VAR_030182
Natural varianti756 – 7561N → I.2 Publications
Corresponds to variant rs12572012 [ dbSNP | Ensembl ].
VAR_030183
Natural varianti789 – 7891H → L.2 Publications
Corresponds to variant rs3758388 [ dbSNP | Ensembl ].
VAR_030184
Natural varianti1011 – 10111D → E.
Corresponds to variant rs1062465 [ dbSNP | Ensembl ].
VAR_030185
Natural varianti1127 – 11271E → Q.
Corresponds to variant rs11185863 [ dbSNP | Ensembl ].
VAR_030186
Natural varianti1177 – 11771C → R.6 Publications
Corresponds to variant rs1886996 [ dbSNP | Ensembl ].
VAR_030187
Natural varianti1219 – 12191N → S.
Corresponds to variant rs1886997 [ dbSNP | Ensembl ].
VAR_030188
Natural varianti1789 – 17891I → V.
Corresponds to variant rs3758390 [ dbSNP | Ensembl ].
VAR_030189

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 13081308Missing in isoform 5. 1 PublicationVSP_022618Add
BLAST
Alternative sequencei668 – 70740Missing in isoform 3. 4 PublicationsVSP_022619Add
BLAST
Alternative sequencei849 – 8491G → GTTSAASSRRLRKLISKPKK GVNRTRQTEGHSLV in isoform 2. 1 PublicationVSP_022620
Alternative sequencei1664 – 172259DLVKC…GVNLA → SASPPPKECSSSPAMEQSWK ENDFDKLREEGFRRSNYSEL QEEIQTKGKEVENFEKNLD in isoform 4. 1 PublicationVSP_022621Add
BLAST
Alternative sequencei1723 – 182098Missing in isoform 4. 1 PublicationVSP_022622Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB033337 mRNA. Translation: BAB69456.1.
AB033338 mRNA. Translation: BAB20417.1.
AL117496 mRNA. Translation: CAB55962.1.
AK024959 mRNA. Translation: BAB15043.1. Sequence problems.
AK025628 mRNA. Translation: BAB15194.1.
AL157389, AL157400 Genomic DNA. Translation: CAI12885.1. Sequence problems.
AL157389, AL157400 Genomic DNA. Translation: CAI12886.1.
AL157389, AL157400 Genomic DNA. Translation: CAI12887.1.
AL157400, AL157389 Genomic DNA. Translation: CAI16829.1. Sequence problems.
AL157400, AL157389 Genomic DNA. Translation: CAI16830.1.
AL157400, AL157389 Genomic DNA. Translation: CAI16831.1.
AL157400 Genomic DNA. Translation: CAI16832.1.
AY282406 mRNA. Translation: AAP40330.1.
AY282407 mRNA. Translation: AAP40331.1.
BC046134 mRNA. Translation: AAH46134.1. Sequence problems.
BC058913 mRNA. Translation: AAH58913.1. Sequence problems.
BC093089 mRNA. Translation: AAH93089.1. Sequence problems.
BC108688 mRNA. Translation: AAI08689.1. Sequence problems.
AL137392 mRNA. Translation: CAB70720.1.
U93121 mRNA. Translation: AAB88727.1.
AY739715 mRNA. Translation: AAW65984.1.
L16782 mRNA. Translation: AAC37542.1.
CCDSiCCDS60590.1. [Q96Q89-1]
CCDS7407.1. [Q96Q89-3]
PIRiT17272.
RefSeqiNP_001271188.1. NM_001284259.1. [Q96Q89-1]
NP_057279.2. NM_016195.3. [Q96Q89-3]
UniGeneiHs.240.

Genome annotation databases

EnsembliENST00000260753; ENSP00000260753; ENSG00000138182. [Q96Q89-3]
ENST00000371728; ENSP00000360793; ENSG00000138182. [Q96Q89-1]
GeneIDi9585.
KEGGihsa:9585.
UCSCiuc001kgr.1. human. [Q96Q89-3]
uc001kgs.1. human. [Q96Q89-1]

Polymorphism databases

DMDMi308153587.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB033337 mRNA. Translation: BAB69456.1 .
AB033338 mRNA. Translation: BAB20417.1 .
AL117496 mRNA. Translation: CAB55962.1 .
AK024959 mRNA. Translation: BAB15043.1 . Sequence problems.
AK025628 mRNA. Translation: BAB15194.1 .
AL157389 , AL157400 Genomic DNA. Translation: CAI12885.1 . Sequence problems.
AL157389 , AL157400 Genomic DNA. Translation: CAI12886.1 .
AL157389 , AL157400 Genomic DNA. Translation: CAI12887.1 .
AL157400 , AL157389 Genomic DNA. Translation: CAI16829.1 . Sequence problems.
AL157400 , AL157389 Genomic DNA. Translation: CAI16830.1 .
AL157400 , AL157389 Genomic DNA. Translation: CAI16831.1 .
AL157400 Genomic DNA. Translation: CAI16832.1 .
AY282406 mRNA. Translation: AAP40330.1 .
AY282407 mRNA. Translation: AAP40331.1 .
BC046134 mRNA. Translation: AAH46134.1 . Sequence problems.
BC058913 mRNA. Translation: AAH58913.1 . Sequence problems.
BC093089 mRNA. Translation: AAH93089.1 . Sequence problems.
BC108688 mRNA. Translation: AAI08689.1 . Sequence problems.
AL137392 mRNA. Translation: CAB70720.1 .
U93121 mRNA. Translation: AAB88727.1 .
AY739715 mRNA. Translation: AAW65984.1 .
L16782 mRNA. Translation: AAC37542.1 .
CCDSi CCDS60590.1. [Q96Q89-1 ]
CCDS7407.1. [Q96Q89-3 ]
PIRi T17272.
RefSeqi NP_001271188.1. NM_001284259.1. [Q96Q89-1 ]
NP_057279.2. NM_016195.3. [Q96Q89-3 ]
UniGenei Hs.240.

3D structure databases

ProteinModelPortali Q96Q89.
SMRi Q96Q89. Positions 56-479.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114953. 5 interactions.
DIPi DIP-103N.
IntActi Q96Q89. 5 interactions.
MINTi MINT-4712270.

Chemistry

ChEMBLi CHEMBL2021752.

PTM databases

PhosphoSitei Q96Q89.

Polymorphism databases

DMDMi 308153587.

Proteomic databases

MaxQBi Q96Q89.
PaxDbi Q96Q89.
PRIDEi Q96Q89.

Protocols and materials databases

DNASUi 9585.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000260753 ; ENSP00000260753 ; ENSG00000138182 . [Q96Q89-3 ]
ENST00000371728 ; ENSP00000360793 ; ENSG00000138182 . [Q96Q89-1 ]
GeneIDi 9585.
KEGGi hsa:9585.
UCSCi uc001kgr.1. human. [Q96Q89-3 ]
uc001kgs.1. human. [Q96Q89-1 ]

Organism-specific databases

CTDi 9585.
GeneCardsi GC10P091452.
HGNCi HGNC:7212. KIF20B.
HPAi HPA031263.
HPA050214.
MIMi 605498. gene.
neXtProti NX_Q96Q89.
PharmGKBi PA162393285.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5059.
GeneTreei ENSGT00760000118872.
HOVERGENi HBG106760.
InParanoidi Q96Q89.
KOi K10402.
OrthoDBi EOG7TTQ73.
PhylomeDBi Q96Q89.
TreeFami TF105232.

Miscellaneous databases

ChiTaRSi KIF20B. human.
GeneWikii MPHOSPH1.
GenomeRNAii 9585.
NextBioi 35959.
PROi Q96Q89.
SOURCEi Search...

Gene expression databases

Bgeei Q96Q89.
Genevestigatori Q96Q89.

Family and domain databases

Gene3Di 3.40.850.10. 2 hits.
InterProi IPR028828. KIF20B.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR23165. PTHR23165. 1 hit.
Pfami PF00225. Kinesin. 1 hit.
[Graphical view ]
PRINTSi PR00380. KINESINHEAVY.
SMARTi SM00129. KISc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
PROSITEi PS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel kinesin-related protein, KRMP1, as a target for mitotic peptidyl-prolyl isomerase Pin1."
    Kamimoto T., Zama T., Aoki R., Muro Y., Hagiwara M.
    J. Biol. Chem. 276:37520-37528(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), SUBCELLULAR LOCATION, INTERACTION WITH PIN1, PHOSPHORYLATION AT THR-1644, VARIANTS ILE-756; LEU-789 AND ARG-1177.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANTS ASP-490 AND ARG-1177.
    Tissue: Testis.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 779-1480 (ISOFORMS 1/2/3/4), VARIANT ARG-1177.
    Tissue: Colon.
  4. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "M phase phosphoprotein 1 is a human plus-end-directed kinesin-related protein required for cytokinesis."
    Abaza A., Soleilhac J.-M., Westendorf J., Piel M., Crevel I., Roux A., Pirollet F.
    J. Biol. Chem. 278:27844-27852(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-957 (ISOFORM 3), NUCLEOTIDE SEQUENCE [MRNA] OF 705-1820 (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, VARIANTS ILE-756; LEU-789 AND ARG-1177.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-740 (ISOFORM 3), VARIANT ASP-490.
    Tissue: Lung, Lymph and Testis.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 575-1820 (ISOFORM 3).
    Tissue: Testis.
  8. "Autoantibodies from patients with idiopathic ataxia bind to M-phase phosphoprotein-1 (MPP1)."
    Fritzler M.J., Kerfoot S.M., Feasby T.E., Zochodne D.W., Westendorf J.M., Dalmau J.O., Chan E.K.
    J. Invest. Med. 48:28-39(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1068-1820 (ISOFORMS 1/2/3), VARIANT ARG-1177.
  9. "Anti-leukemia-specific humoral immune response in children with T-lineage acute lymphoblastic leukemia."
    Dohnal A.M., Panzer-Gruemayer R.E.
    Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1106-1820 (ISOFORM 4), VARIANT ARG-1177.
  10. "Cloning of cDNAs for M-phase phosphoproteins recognized by the MPM2 monoclonal antibody and determination of the phosphorylated epitope."
    Westendorf J.M., Rao P.N., Gerace L.
    Proc. Natl. Acad. Sci. U.S.A. 91:714-718(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1255-1820 (ISOFORMS 1/2/3).
  11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-488, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1658, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiKI20B_HUMAN
AccessioniPrimary (citable) accession number: Q96Q89
Secondary accession number(s): A8MXM7
, O43277, Q09471, Q2KQ73, Q32NE1, Q561V3, Q58EX8, Q5T9M8, Q5T9M9, Q5T9N0, Q5T9N1, Q7KZ68, Q7Z5E0, Q7Z5E1, Q7Z6M9, Q86X82, Q9H3R8, Q9H6Q9, Q9H755, Q9NTC1, Q9UFR5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: October 5, 2010
Last modified: October 29, 2014
This is version 103 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3