Q96Q89 (KI20B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Kinesin-like protein KIF20B

Alternative name(s):
Cancer/testis antigen 90
Short name=CT90
Kinesin-related motor interacting with PIN1
M-phase phosphoprotein 1
Short name=MPP1

Gene names

Name:	KIF20B
Synonyms:	KRMP1, MPHOSPH1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1820 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Plus-end-directed motor enzyme that is required for completion of cytokinesis. Ref.5
Subunit structure	Interacts with PIN1. Ref.1
Subcellular location	Cytoplasm. Nucleus. Cytoplasm › cytoskeleton › spindle. Note: Localizes mainly in the nucleus during interphase although it is also detected in the cytoplasm without clear association with microtubules. A 2-3 fold expression increase is seen as cells progress from G1 to G2/M phase. During prophase and metaphase it is found throughout the cytoplasm and at anaphase accumulates at the midplan of the cell and forms a distinct band extending across the spindle midzone. At anaphase it is concentrated in the mid-body. Ref.1 Ref.5
Tissue specificity	Brain, ovary, kidney and testis. Ref.5
Sequence similarities	Belongs to the kinesin-like protein family. Contains 1 kinesin-motor domain.
Sequence caution	The sequence AAH46134.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence. The sequence AAH58913.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence. The sequence AAH93089.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence. The sequence AAI08689.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence. The sequence BAB15043.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence. The sequence CAI12885.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI16829.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Cell cycle Cell division Mitosis
Cellular component	Cytoplasm Cytoskeleton Microtubule Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
Ligand	ATP-binding Nucleotide-binding
Molecular function	Motor protein
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	M phase of mitotic cell cycle Traceable author statement PubMed 8885239. Source: ProtInc cell cycle arrest Non-traceable author statement Ref.1. Source: UniProtKB cell division Inferred from electronic annotation. Source: UniProtKB-KW microtubule-based movement Inferred from electronic annotation. Source: InterPro mitosis Inferred from electronic annotation. Source: UniProtKB-KW regulation of mitosis Non-traceable author statement Ref.1. Source: UniProtKB
Cellular_component	centrosome Inferred from direct assay Ref.1. Source: UniProtKB cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell microtubule Inferred from electronic annotation. Source: UniProtKB-KW microtubule associated complex Inferred from electronic annotation. Source: InterPro nucleolus Inferred from direct assay Ref.1. Source: UniProtKB nucleoplasm Inferred from direct assay Ref.1. Source: UniProtKB spindle Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity Inferred from direct assay Ref.1. Source: UniProtKB microtubule motor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96Q89-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96Q89-2)

The sequence of this isoform differs from the canonical sequence as follows:
     849-849: G → GTTSAASSRRLRKLISKPKKGVNRTRQTEGHSLV

Isoform 3 (identifier: Q96Q89-3)

The sequence of this isoform differs from the canonical sequence as follows:
     668-707: Missing.

Isoform 4 (identifier: Q96Q89-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1664-1722: DLVKCENKKN...QASIIGVNLA → SASPPPKECS...EVENFEKNLD
     1723-1820: Missing.

Isoform 5 (identifier: Q96Q89-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1308: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1820	1820	Kinesin-like protein KIF20B		PRO_0000274053
Regions
	Domain	55 – 405	351	Kinesin-motor
	Nucleotide binding	152 – 159	8	ATP Potential
	Region	1560 – 1820	261	Interaction with PIN1
	Coiled coil	523 – 603	81	Potential
	Coiled coil	674 – 793	120	Potential
	Compositional bias	1247 – 1251	5	Poly-Glu
Amino acid modifications
	Modified residue	303	1	Phosphoserine By similarity
	Modified residue	488	1	Phosphoserine Ref.11
	Modified residue	1644	1	Phosphothreonine; by CDK1 Ref.1
	Modified residue	1658	1	Phosphoserine Ref.12
Natural variations
	Alternative sequence	1 – 1308	1308	Missing in isoform 5.		VSP_022618
	Alternative sequence	668 – 707	40	Missing in isoform 3.		VSP_022619
	Alternative sequence	849	1	G → GTTSAASSRRLRKLISKPKK GVNRTRQTEGHSLV in isoform 2.		VSP_022620
	Alternative sequence	1664 – 1722	59	DLVKC…GVNLA → SASPPPKECSSSPAMEQSWK ENDFDKLREEGFRRSNYSEL QEEIQTKGKEVENFEKNLD in isoform 4.		VSP_022621
	Alternative sequence	1723 – 1820	98	Missing in isoform 4.		VSP_022622
	Natural variant	50	1	A → G. Corresponds to variant rs1129777 [ dbSNP | Ensembl ].		VAR_030181
	Natural variant	490	1	E → D. Ref.2 Ref.6 Corresponds to variant rs17484219 [ dbSNP | Ensembl ].		VAR_030182
	Natural variant	756	1	N → I. Ref.1 Ref.5 Corresponds to variant rs12572012 [ dbSNP | Ensembl ].		VAR_030183
	Natural variant	789	1	H → L. Ref.1 Ref.5 Corresponds to variant rs3758388 [ dbSNP | Ensembl ].		VAR_030184
	Natural variant	1011	1	D → E. Corresponds to variant rs1062465 [ dbSNP | Ensembl ].		VAR_030185
	Natural variant	1127	1	E → Q. Corresponds to variant rs11185863 [ dbSNP | Ensembl ].		VAR_030186
	Natural variant	1177	1	C → R. Ref.1 Ref.2 Ref.3 Ref.5 Ref.8 Ref.9 Corresponds to variant rs1886996 [ dbSNP | Ensembl ].		VAR_030187
	Natural variant	1219	1	N → S. Corresponds to variant rs1886997 [ dbSNP | Ensembl ].		VAR_030188
	Natural variant	1789	1	I → V. Corresponds to variant rs3758390 [ dbSNP | Ensembl ].		VAR_030189
Experimental info
	Sequence conflict	266	1	S → T in BAB69456. Ref.1
	Sequence conflict	296 – 297	2	KR → NT in BAB69456. Ref.1
	Sequence conflict	357	1	V → I in BAB69456. Ref.1
	Sequence conflict	388	1	M → V in BAB69456. Ref.1
	Sequence conflict	593	1	E → K in AAI08689. Ref.6
	Sequence conflict	705 – 707	3	DPQ → ETE in AAP40331. Ref.5
	Sequence conflict	753	1	E → K in BAB69456. Ref.1
	Sequence conflict	797	1	N → S in BAB15043. Ref.3
	Sequence conflict	870	1	N → S in BAB15043. Ref.3
	Sequence conflict	915	1	F → S in BAB15043. Ref.3
	Sequence conflict	1105	1	K → R in BAB15043. Ref.3
	Sequence conflict	1302	1	V → E in AAC37542. Ref.10
	Sequence conflict	1459	1	R → S in AAC37542. Ref.10
	Sequence conflict	1608	1	V → A in BAB69456. Ref.1
	Sequence conflict	1649	1	K → E in CAB55962. Ref.2
	Sequence conflict	1649	1	K → E in BAB15194. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 5, 2010. Version 3. Checksum: 8A6FE95A6F3BA20C	FASTA	1,820	210,629
	10 20 30 40 50 60 MESNFNQEGV PRPSYVFSAD PIARPSEINF DGIKLDLSHE FSLVAPNTEA NSFESKDYLQ 70 80 90 100 110 120 VCLRIRPFTQ SEKELESEGC VHILDSQTVV LKEPQCILGR LSEKSSGQMA QKFSFSKVFG 130 140 150 160 170 180 PATTQKEFFQ GCIMQPVKDL LKGQSRLIFT YGLTNSGKTY TFQGTEENIG ILPRTLNVLF 190 200 210 220 230 240 DSLQERLYTK MNLKPHRSRE YLRLSSEQEK EEIASKSALL RQIKEVTVHN DSDDTLYGSL 250 260 270 280 290 300 TNSLNISEFE ESIKDYEQAN LNMANSIKFS VWVSFFEIYN EYIYDLFVPV SSKFQKRKML 310 320 330 340 350 360 RLSQDVKGYS FIKDLQWIQV SDSKEAYRLL KLGIKHQSVA FTKLNNASSR SHSIFTVKIL 370 380 390 400 410 420 QIEDSEMSRV IRVSELSLCD LAGSERTMKT QNEGERLRET GNINTSLLTL GKCINVLKNS 430 440 450 460 470 480 EKSKFQQHVP FRESKLTHYF QSFFNGKGKI CMIVNISQCY LAYDETLNVL KFSAIAQKVC 490 500 510 520 530 540 VPDTLNSSQE KLFGPVKSSQ DVSLDSNSNS KILNVKRATI SWENSLEDLM EDEDLVEELE 550 560 570 580 590 600 NAEETQNVET KLLDEDLDKT LEENKAFISH EEKRKLLDLI EDLKKKLINE KKEKLTLEFK 610 620 630 640 650 660 IREEVTQEFT QYWAQREADF KETLLQEREI LEENAERRLA IFKDLVGKCD TREEAAKDIC 670 680 690 700 710 720 ATKVETEETH NYVGFEDIID SLQDNVADIK KQAEIAHLYI ASLPDPQEAT ACLELKFNQI 730 740 750 760 770 780 KAELAKTKGE LIKTKEELKK RENESDSLIQ ELETSNKKII TQNQRIKELI NIIDQKEDTI 790 800 810 820 830 840 NEFQNLKSHM ENTFKCNDKA DTSSLIINNK LICNETVEVP KDSKSKICSE RKRVNENELQ 850 860 870 880 890 900 QDEPPAKKGS IHVSSAITED QKKSEEVRPN IAEIEDIRVL QENNEGLRAF LLTIENELKN 910 920 930 940 950 960 EKEEKAELNK QIVHFQQELS LSEKKNLTLS KEVQQIQSNY DIAIAELHVQ KSKNQEQEEK 970 980 990 1000 1010 1020 IMKLSNEIET ATRSITNNVS QIKLMHTKID ELRTLDSVSQ ISNIDLLNLR DLSNGSEEDN 1030 1040 1050 1060 1070 1080 LPNTQLDLLG NDYLVSKQVK EYRIQEPNRE NSFHSSIEAI WEECKEIVKA SSKKSHQIEE 1090 1100 1110 1120 1130 1140 LEQQIEKLQA EVKGYKDENN RLKEKEHKNQ DDLLKEKETL IQQLKEELQE KNVTLDVQIQ 1150 1160 1170 1180 1190 1200 HVVEGKRALS ELTQGVTCYK AKIKELETIL ETQKVECSHS AKLEQDILEK ESIILKLERN 1210 1220 1230 1240 1250 1260 LKEFQEHLQD SVKNTKDLNV KELKLKEEIT QLTNNLQDMK HLLQLKEEEE ETNRQETEKL 1270 1280 1290 1300 1310 1320 KEELSASSAR TQNLKADLQR KEEDYADLKE KLTDAKKQIK QVQKEVSVMR DEDKLLRIKI 1330 1340 1350 1360 1370 1380 NELEKKKNQC SQELDMKQRT IQQLKEQLNN QKVEEAIQQY ERACKDLNVK EKIIEDMRMT 1390 1400 1410 1420 1430 1440 LEEQEQTQVE QDQVLEAKLE EVERLATELE KWKEKCNDLE TKNNQRSNKE HENNTDVLGK 1450 1460 1470 1480 1490 1500 LTNLQDELQE SEQKYNADRK KWLEEKMMLI TQAKEAENIR NKEMKKYAED RERFFKQQNE 1510 1520 1530 1540 1550 1560 MEILTAQLTE KDSDLQKWRE ERDQLVAALE IQLKALISSN VQKDNEIEQL KRIISETSKI 1570 1580 1590 1600 1610 1620 ETQIMDIKPK RISSADPDKL QTEPLSTSFE ISRNKIEDGS VVLDSCEVST ENDQSTRFPK 1630 1640 1650 1660 1670 1680 PELEIQFTPL QPNKMAVKHP GCTTPVTVKI PKARKRKSNE MEEDLVKCEN KKNATPRTNL 1690 1700 1710 1720 1730 1740 KFPISDDRNS SVKKEQKVAI RPSSKKTYSL RSQASIIGVN LATKKKEGTL QKFGDFLQHS 1750 1760 1770 1780 1790 1800 PSILQSKAKK IIETMSSSKL SNVEASKENV SQPKRAKRKL YTSEISSPID ISGQVILMDQ 1810 1820 KMKESDHQII KRRLRTKTAK
	Isoform 2 [UniParc]. Checksum: 07E7FFF9A7D116C5	FASTA	1,853	214,276
	10 20 30 40 50 60 MESNFNQEGV PRPSYVFSAD PIARPSEINF DGIKLDLSHE FSLVAPNTEA NSFESKDYLQ 70 80 90 100 110 120 VCLRIRPFTQ SEKELESEGC VHILDSQTVV LKEPQCILGR LSEKSSGQMA QKFSFSKVFG 130 140 150 160 170 180 PATTQKEFFQ GCIMQPVKDL LKGQSRLIFT YGLTNSGKTY TFQGTEENIG ILPRTLNVLF 190 200 210 220 230 240 DSLQERLYTK MNLKPHRSRE YLRLSSEQEK EEIASKSALL RQIKEVTVHN DSDDTLYGSL 250 260 270 280 290 300 TNSLNISEFE ESIKDYEQAN LNMANSIKFS VWVSFFEIYN EYIYDLFVPV SSKFQKRKML 310 320 330 340 350 360 RLSQDVKGYS FIKDLQWIQV SDSKEAYRLL KLGIKHQSVA FTKLNNASSR SHSIFTVKIL 370 380 390 400 410 420 QIEDSEMSRV IRVSELSLCD LAGSERTMKT QNEGERLRET GNINTSLLTL GKCINVLKNS 430 440 450 460 470 480 EKSKFQQHVP FRESKLTHYF QSFFNGKGKI CMIVNISQCY LAYDETLNVL KFSAIAQKVC 490 500 510 520 530 540 VPDTLNSSQE KLFGPVKSSQ DVSLDSNSNS KILNVKRATI SWENSLEDLM EDEDLVEELE 550 560 570 580 590 600 NAEETQNVET KLLDEDLDKT LEENKAFISH EEKRKLLDLI EDLKKKLINE KKEKLTLEFK 610 620 630 640 650 660 IREEVTQEFT QYWAQREADF KETLLQEREI LEENAERRLA IFKDLVGKCD TREEAAKDIC 670 680 690 700 710 720 ATKVETEETH NYVGFEDIID SLQDNVADIK KQAEIAHLYI ASLPDPQEAT ACLELKFNQI 730 740 750 760 770 780 KAELAKTKGE LIKTKEELKK RENESDSLIQ ELETSNKKII TQNQRIKELI NIIDQKEDTI 790 800 810 820 830 840 NEFQNLKSHM ENTFKCNDKA DTSSLIINNK LICNETVEVP KDSKSKICSE RKRVNENELQ 850 860 870 880 890 900 QDEPPAKKGT TSAASSRRLR KLISKPKKGV NRTRQTEGHS LVSIHVSSAI TEDQKKSEEV 910 920 930 940 950 960 RPNIAEIEDI RVLQENNEGL RAFLLTIENE LKNEKEEKAE LNKQIVHFQQ ELSLSEKKNL 970 980 990 1000 1010 1020 TLSKEVQQIQ SNYDIAIAEL HVQKSKNQEQ EEKIMKLSNE IETATRSITN NVSQIKLMHT 1030 1040 1050 1060 1070 1080 KIDELRTLDS VSQISNIDLL NLRDLSNGSE EDNLPNTQLD LLGNDYLVSK QVKEYRIQEP 1090 1100 1110 1120 1130 1140 NRENSFHSSI EAIWEECKEI VKASSKKSHQ IEELEQQIEK LQAEVKGYKD ENNRLKEKEH 1150 1160 1170 1180 1190 1200 KNQDDLLKEK ETLIQQLKEE LQEKNVTLDV QIQHVVEGKR ALSELTQGVT CYKAKIKELE 1210 1220 1230 1240 1250 1260 TILETQKVEC SHSAKLEQDI LEKESIILKL ERNLKEFQEH LQDSVKNTKD LNVKELKLKE 1270 1280 1290 1300 1310 1320 EITQLTNNLQ DMKHLLQLKE EEEETNRQET EKLKEELSAS SARTQNLKAD LQRKEEDYAD 1330 1340 1350 1360 1370 1380 LKEKLTDAKK QIKQVQKEVS VMRDEDKLLR IKINELEKKK NQCSQELDMK QRTIQQLKEQ 1390 1400 1410 1420 1430 1440 LNNQKVEEAI QQYERACKDL NVKEKIIEDM RMTLEEQEQT QVEQDQVLEA KLEEVERLAT 1450 1460 1470 1480 1490 1500 ELEKWKEKCN DLETKNNQRS NKEHENNTDV LGKLTNLQDE LQESEQKYNA DRKKWLEEKM 1510 1520 1530 1540 1550 1560 MLITQAKEAE NIRNKEMKKY AEDRERFFKQ QNEMEILTAQ LTEKDSDLQK WREERDQLVA 1570 1580 1590 1600 1610 1620 ALEIQLKALI SSNVQKDNEI EQLKRIISET SKIETQIMDI KPKRISSADP DKLQTEPLST 1630 1640 1650 1660 1670 1680 SFEISRNKIE DGSVVLDSCE VSTENDQSTR FPKPELEIQF TPLQPNKMAV KHPGCTTPVT 1690 1700 1710 1720 1730 1740 VKIPKARKRK SNEMEEDLVK CENKKNATPR TNLKFPISDD RNSSVKKEQK VAIRPSSKKT 1750 1760 1770 1780 1790 1800 YSLRSQASII GVNLATKKKE GTLQKFGDFL QHSPSILQSK AKKIIETMSS SKLSNVEASK 1810 1820 1830 1840 1850 ENVSQPKRAK RKLYTSEISS PIDISGQVIL MDQKMKESDH QIIKRRLRTK TAK
	Isoform 3 [UniParc]. Checksum: 084B8D31404946E4	FASTA	1,780	206,136
	10 20 30 40 50 60 MESNFNQEGV PRPSYVFSAD PIARPSEINF DGIKLDLSHE FSLVAPNTEA NSFESKDYLQ 70 80 90 100 110 120 VCLRIRPFTQ SEKELESEGC VHILDSQTVV LKEPQCILGR LSEKSSGQMA QKFSFSKVFG 130 140 150 160 170 180 PATTQKEFFQ GCIMQPVKDL LKGQSRLIFT YGLTNSGKTY TFQGTEENIG ILPRTLNVLF 190 200 210 220 230 240 DSLQERLYTK MNLKPHRSRE YLRLSSEQEK EEIASKSALL RQIKEVTVHN DSDDTLYGSL 250 260 270 280 290 300 TNSLNISEFE ESIKDYEQAN LNMANSIKFS VWVSFFEIYN EYIYDLFVPV SSKFQKRKML 310 320 330 340 350 360 RLSQDVKGYS FIKDLQWIQV SDSKEAYRLL KLGIKHQSVA FTKLNNASSR SHSIFTVKIL 370 380 390 400 410 420 QIEDSEMSRV IRVSELSLCD LAGSERTMKT QNEGERLRET GNINTSLLTL GKCINVLKNS 430 440 450 460 470 480 EKSKFQQHVP FRESKLTHYF QSFFNGKGKI CMIVNISQCY LAYDETLNVL KFSAIAQKVC 490 500 510 520 530 540 VPDTLNSSQE KLFGPVKSSQ DVSLDSNSNS KILNVKRATI SWENSLEDLM EDEDLVEELE 550 560 570 580 590 600 NAEETQNVET KLLDEDLDKT LEENKAFISH EEKRKLLDLI EDLKKKLINE KKEKLTLEFK 610 620 630 640 650 660 IREEVTQEFT QYWAQREADF KETLLQEREI LEENAERRLA IFKDLVGKCD TREEAAKDIC 670 680 690 700 710 720 ATKVETEEAT ACLELKFNQI KAELAKTKGE LIKTKEELKK RENESDSLIQ ELETSNKKII 730 740 750 760 770 780 TQNQRIKELI NIIDQKEDTI NEFQNLKSHM ENTFKCNDKA DTSSLIINNK LICNETVEVP 790 800 810 820 830 840 KDSKSKICSE RKRVNENELQ QDEPPAKKGS IHVSSAITED QKKSEEVRPN IAEIEDIRVL 850 860 870 880 890 900 QENNEGLRAF LLTIENELKN EKEEKAELNK QIVHFQQELS LSEKKNLTLS KEVQQIQSNY 910 920 930 940 950 960 DIAIAELHVQ KSKNQEQEEK IMKLSNEIET ATRSITNNVS QIKLMHTKID ELRTLDSVSQ 970 980 990 1000 1010 1020 ISNIDLLNLR DLSNGSEEDN LPNTQLDLLG NDYLVSKQVK EYRIQEPNRE NSFHSSIEAI 1030 1040 1050 1060 1070 1080 WEECKEIVKA SSKKSHQIEE LEQQIEKLQA EVKGYKDENN RLKEKEHKNQ DDLLKEKETL 1090 1100 1110 1120 1130 1140 IQQLKEELQE KNVTLDVQIQ HVVEGKRALS ELTQGVTCYK AKIKELETIL ETQKVECSHS 1150 1160 1170 1180 1190 1200 AKLEQDILEK ESIILKLERN LKEFQEHLQD SVKNTKDLNV KELKLKEEIT QLTNNLQDMK 1210 1220 1230 1240 1250 1260 HLLQLKEEEE ETNRQETEKL KEELSASSAR TQNLKADLQR KEEDYADLKE KLTDAKKQIK 1270 1280 1290 1300 1310 1320 QVQKEVSVMR DEDKLLRIKI NELEKKKNQC SQELDMKQRT IQQLKEQLNN QKVEEAIQQY 1330 1340 1350 1360 1370 1380 ERACKDLNVK EKIIEDMRMT LEEQEQTQVE QDQVLEAKLE EVERLATELE KWKEKCNDLE 1390 1400 1410 1420 1430 1440 TKNNQRSNKE HENNTDVLGK LTNLQDELQE SEQKYNADRK KWLEEKMMLI TQAKEAENIR 1450 1460 1470 1480 1490 1500 NKEMKKYAED RERFFKQQNE MEILTAQLTE KDSDLQKWRE ERDQLVAALE IQLKALISSN 1510 1520 1530 1540 1550 1560 VQKDNEIEQL KRIISETSKI ETQIMDIKPK RISSADPDKL QTEPLSTSFE ISRNKIEDGS 1570 1580 1590 1600 1610 1620 VVLDSCEVST ENDQSTRFPK PELEIQFTPL QPNKMAVKHP GCTTPVTVKI PKARKRKSNE 1630 1640 1650 1660 1670 1680 MEEDLVKCEN KKNATPRTNL KFPISDDRNS SVKKEQKVAI RPSSKKTYSL RSQASIIGVN 1690 1700 1710 1720 1730 1740 LATKKKEGTL QKFGDFLQHS PSILQSKAKK IIETMSSSKL SNVEASKENV SQPKRAKRKL 1750 1760 1770 1780 YTSEISSPID ISGQVILMDQ KMKESDHQII KRRLRTKTAK
	Isoform 4 [UniParc]. Checksum: 6B5B4801B38BFF40	FASTA	1,722	199,810
	10 20 30 40 50 60 MESNFNQEGV PRPSYVFSAD PIARPSEINF DGIKLDLSHE FSLVAPNTEA NSFESKDYLQ 70 80 90 100 110 120 VCLRIRPFTQ SEKELESEGC VHILDSQTVV LKEPQCILGR LSEKSSGQMA QKFSFSKVFG 130 140 150 160 170 180 PATTQKEFFQ GCIMQPVKDL LKGQSRLIFT YGLTNSGKTY TFQGTEENIG ILPRTLNVLF 190 200 210 220 230 240 DSLQERLYTK MNLKPHRSRE YLRLSSEQEK EEIASKSALL RQIKEVTVHN DSDDTLYGSL 250 260 270 280 290 300 TNSLNISEFE ESIKDYEQAN LNMANSIKFS VWVSFFEIYN EYIYDLFVPV SSKFQKRKML 310 320 330 340 350 360 RLSQDVKGYS FIKDLQWIQV SDSKEAYRLL KLGIKHQSVA FTKLNNASSR SHSIFTVKIL 370 380 390 400 410 420 QIEDSEMSRV IRVSELSLCD LAGSERTMKT QNEGERLRET GNINTSLLTL GKCINVLKNS 430 440 450 460 470 480 EKSKFQQHVP FRESKLTHYF QSFFNGKGKI CMIVNISQCY LAYDETLNVL KFSAIAQKVC 490 500 510 520 530 540 VPDTLNSSQE KLFGPVKSSQ DVSLDSNSNS KILNVKRATI SWENSLEDLM EDEDLVEELE 550 560 570 580 590 600 NAEETQNVET KLLDEDLDKT LEENKAFISH EEKRKLLDLI EDLKKKLINE KKEKLTLEFK 610 620 630 640 650 660 IREEVTQEFT QYWAQREADF KETLLQEREI LEENAERRLA IFKDLVGKCD TREEAAKDIC 670 680 690 700 710 720 ATKVETEETH NYVGFEDIID SLQDNVADIK KQAEIAHLYI ASLPDPQEAT ACLELKFNQI 730 740 750 760 770 780 KAELAKTKGE LIKTKEELKK RENESDSLIQ ELETSNKKII TQNQRIKELI NIIDQKEDTI 790 800 810 820 830 840 NEFQNLKSHM ENTFKCNDKA DTSSLIINNK LICNETVEVP KDSKSKICSE RKRVNENELQ 850 860 870 880 890 900 QDEPPAKKGS IHVSSAITED QKKSEEVRPN IAEIEDIRVL QENNEGLRAF LLTIENELKN 910 920 930 940 950 960 EKEEKAELNK QIVHFQQELS LSEKKNLTLS KEVQQIQSNY DIAIAELHVQ KSKNQEQEEK 970 980 990 1000 1010 1020 IMKLSNEIET ATRSITNNVS QIKLMHTKID ELRTLDSVSQ ISNIDLLNLR DLSNGSEEDN 1030 1040 1050 1060 1070 1080 LPNTQLDLLG NDYLVSKQVK EYRIQEPNRE NSFHSSIEAI WEECKEIVKA SSKKSHQIEE 1090 1100 1110 1120 1130 1140 LEQQIEKLQA EVKGYKDENN RLKEKEHKNQ DDLLKEKETL IQQLKEELQE KNVTLDVQIQ 1150 1160 1170 1180 1190 1200 HVVEGKRALS ELTQGVTCYK AKIKELETIL ETQKVECSHS AKLEQDILEK ESIILKLERN 1210 1220 1230 1240 1250 1260 LKEFQEHLQD SVKNTKDLNV KELKLKEEIT QLTNNLQDMK HLLQLKEEEE ETNRQETEKL 1270 1280 1290 1300 1310 1320 KEELSASSAR TQNLKADLQR KEEDYADLKE KLTDAKKQIK QVQKEVSVMR DEDKLLRIKI 1330 1340 1350 1360 1370 1380 NELEKKKNQC SQELDMKQRT IQQLKEQLNN QKVEEAIQQY ERACKDLNVK EKIIEDMRMT 1390 1400 1410 1420 1430 1440 LEEQEQTQVE QDQVLEAKLE EVERLATELE KWKEKCNDLE TKNNQRSNKE HENNTDVLGK 1450 1460 1470 1480 1490 1500 LTNLQDELQE SEQKYNADRK KWLEEKMMLI TQAKEAENIR NKEMKKYAED RERFFKQQNE 1510 1520 1530 1540 1550 1560 MEILTAQLTE KDSDLQKWRE ERDQLVAALE IQLKALISSN VQKDNEIEQL KRIISETSKI 1570 1580 1590 1600 1610 1620 ETQIMDIKPK RISSADPDKL QTEPLSTSFE ISRNKIEDGS VVLDSCEVST ENDQSTRFPK 1630 1640 1650 1660 1670 1680 PELEIQFTPL QPNKMAVKHP GCTTPVTVKI PKARKRKSNE MEESASPPPK ECSSSPAMEQ 1690 1700 1710 1720 SWKENDFDKL REEGFRRSNY SELQEEIQTK GKEVENFEKN LD
	Isoform 5 [UniParc]. Checksum: 15D67C1B5D1FBD7B	FASTA	512	59,621
	10 20 30 40 50 60 MRDEDKLLRI KINELEKKKN QCSQELDMKQ RTIQQLKEQL NNQKVEEAIQ QYERACKDLN 70 80 90 100 110 120 VKEKIIEDMR MTLEEQEQTQ VEQDQVLEAK LEEVERLATE LEKWKEKCND LETKNNQRSN 130 140 150 160 170 180 KEHENNTDVL GKLTNLQDEL QESEQKYNAD RKKWLEEKMM LITQAKEAEN IRNKEMKKYA 190 200 210 220 230 240 EDRERFFKQQ NEMEILTAQL TEKDSDLQKW REERDQLVAA LEIQLKALIS SNVQKDNEIE 250 260 270 280 290 300 QLKRIISETS KIETQIMDIK PKRISSADPD KLQTEPLSTS FEISRNKIED GSVVLDSCEV 310 320 330 340 350 360 STENDQSTRF PKPELEIQFT PLQPNKMAVK HPGCTTPVTV KIPKARKRKS NEMEEDLVKC 370 380 390 400 410 420 ENKKNATPRT NLKFPISDDR NSSVKKEQKV AIRPSSKKTY SLRSQASIIG VNLATKKKEG 430 440 450 460 470 480 TLQKFGDFLQ HSPSILQSKA KKIIETMSSS KLSNVEASKE NVSQPKRAKR KLYTSEISSP 490 500 510 IDISGQVILM DQKMKESDHQ IIKRRLRTKT AK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a novel kinesin-related protein, KRMP1, as a target for mitotic peptidyl-prolyl isomerase Pin1." Kamimoto T., Zama T., Aoki R., Muro Y., Hagiwara M. J. Biol. Chem. 276:37520-37528(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), SUBCELLULAR LOCATION, INTERACTION WITH PIN1, PHOSPHORYLATION AT THR-1644, VARIANTS ILE-756; LEU-789 AND ARG-1177.
[2]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A. Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANTS ASP-490 AND ARG-1177. Tissue: Testis.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 779-1480 (ISOFORMS 1/2/3/4), VARIANT ARG-1177. Tissue: Colon.
[4]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"M phase phosphoprotein 1 is a human plus-end-directed kinesin-related protein required for cytokinesis." Abaza A., Soleilhac J.-M., Westendorf J., Piel M., Crevel I., Roux A., Pirollet F. J. Biol. Chem. 278:27844-27852(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-957 (ISOFORM 3), NUCLEOTIDE SEQUENCE [MRNA] OF 705-1820 (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, VARIANTS ILE-756; LEU-789 AND ARG-1177.
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-740 (ISOFORM 3), VARIANT ASP-490. Tissue: Lung, Lymph and Testis.
[7]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 575-1820 (ISOFORM 3). Tissue: Testis.
[8]	"Autoantibodies from patients with idiopathic ataxia bind to M-phase phosphoprotein-1 (MPP1)." Fritzler M.J., Kerfoot S.M., Feasby T.E., Zochodne D.W., Westendorf J.M., Dalmau J.O., Chan E.K. J. Invest. Med. 48:28-39(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1068-1820 (ISOFORMS 1/2/3), VARIANT ARG-1177.
[9]	"Anti-leukemia-specific humoral immune response in children with T-lineage acute lymphoblastic leukemia." Dohnal A.M., Panzer-Gruemayer R.E. Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1106-1820 (ISOFORM 4), VARIANT ARG-1177.
[10]	"Cloning of cDNAs for M-phase phosphoproteins recognized by the MPM2 monoclonal antibody and determination of the phosphorylated epitope." Westendorf J.M., Rao P.N., Gerace L. Proc. Natl. Acad. Sci. U.S.A. 91:714-718(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1255-1820 (ISOFORMS 1/2/3).
[11]	"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-488, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[12]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1658, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB033337 mRNA. Translation: BAB69456.1. AB033338 mRNA. Translation: BAB20417.1. AL117496 mRNA. Translation: CAB55962.1. AK024959 mRNA. Translation: BAB15043.1. Sequence problems. AK025628 mRNA. Translation: BAB15194.1. AL157389, AL157400 Genomic DNA. Translation: CAI12885.1. Sequence problems. AL157389, AL157400 Genomic DNA. Translation: CAI12886.1. AL157389, AL157400 Genomic DNA. Translation: CAI12887.1. AL157400, AL157389 Genomic DNA. Translation: CAI16829.1. Sequence problems. AL157400, AL157389 Genomic DNA. Translation: CAI16830.1. AL157400, AL157389 Genomic DNA. Translation: CAI16831.1. AL157400 Genomic DNA. Translation: CAI16832.1. AY282406 mRNA. Translation: AAP40330.1. AY282407 mRNA. Translation: AAP40331.1. BC046134 mRNA. Translation: AAH46134.1. Sequence problems. BC058913 mRNA. Translation: AAH58913.1. Sequence problems. BC093089 mRNA. Translation: AAH93089.1. Sequence problems. BC108688 mRNA. Translation: AAI08689.1. Sequence problems. AL137392 mRNA. Translation: CAB70720.1. U93121 mRNA. Translation: AAB88727.1. AY739715 mRNA. Translation: AAW65984.1. L16782 mRNA. Translation: AAC37542.1.
IPI	IPI00044751. IPI00412862. IPI00644494. IPI00827503. IPI00827980.
PIR	T17272.
RefSeq	NP_057279.2. NM_016195.2.
UniGene	Hs.240.
3D structure databases
HSSP	HSSP built from PDB template 1T5C based on UniProtKB Q02224.
ProteinModelPortal	Q96Q89.
SMR	Q96Q89. Positions 56-489.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-103N.
IntAct	Q96Q89. 4 interactions.
PTM databases
PhosphoSite	Q96Q89.
Polymorphism databases
DMDM	308153587.
Proteomic databases
PaxDb	Q96Q89.
PRIDE	Q96Q89.
Protocols and materials databases
DNASU	9585.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000260753; ENSP00000260753; ENSG00000138182. ENST00000371728; ENSP00000360793; ENSG00000138182. ENST00000394289; ENSP00000377830; ENSG00000138182. ENST00000447580; ENSP00000390946; ENSG00000138182.
GeneID	9585.
KEGG	hsa:9585.
UCSC	uc001kgr.1. human. uc001kgs.1. human.
Organism-specific databases
CTD	9585.
GeneCards	GC10P091452.
HGNC	HGNC:7212. KIF20B.
HPA	HPA031263.
MIM	605498. gene.
neXtProt	NX_Q96Q89.
PharmGKB	PA162393285.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5059.
HOVERGEN	HBG106760.
InParanoid	Q96Q89.
PhylomeDB	Q96Q89.
Gene expression databases
ArrayExpress	Q96Q89.
Bgee	Q96Q89.
Genevestigator	Q96Q89.
Family and domain databases
Gene3D	3.40.850.10. 2 hits.
InterPro	IPR019821. Kinesin_motor_CS. IPR001752. Kinesin_motor_dom. [Graphical view]
Pfam	PF00225. Kinesin. 1 hit. [Graphical view]
PRINTS	PR00380. KINESINHEAVY.
SMART	SM00129. KISc. 1 hit. [Graphical view]
PROSITE	PS00411. KINESIN_MOTOR_DOMAIN1. 1 hit. PS50067. KINESIN_MOTOR_DOMAIN2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	KIF20B. human.
GenomeRNAi	9585.
NextBio	35959.
SOURCE	Search...

Entry information

Entry name

KI20B_HUMAN

Accession

Primary (citable) accession number: Q96Q89
Secondary accession number(s): A8MXM7 , O43277, Q09471, Q2KQ73, Q32NE1, Q561V3, Q58EX8, Q5T9M8, Q5T9M9, Q5T9N0, Q5T9N1, Q7KZ68, Q7Z5E0, Q7Z5E1, Q7Z6M9, Q86X82, Q9H3R8, Q9H6Q9, Q9H755, Q9NTC1, Q9UFR5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2007
Last sequence update:	October 5, 2010
Last modified:	May 1, 2013
This is version 88 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.