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Protein

Derlin-3

Gene

DERL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate.2 Publications

GO - Biological processi

  • endoplasmic reticulum unfolded protein response Source: UniProtKB
  • ER-associated ubiquitin-dependent protein catabolic process Source: UniProtKB
  • negative regulation of retrograde protein transport, ER to cytosol Source: ParkinsonsUK-UCL
  • protein N-linked glycosylation via asparagine Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Derlin-3
Alternative name(s):
Degradation in endoplasmic reticulum protein 3
Short name:
DERtrin-3
Der1-like protein 3
Gene namesi
Name:DERL3
Synonyms:C22orf14, DER3, LLN2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componentsi: Chromosome 22, Unplaced

Organism-specific databases

HGNCiHGNC:14236. DERL3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2222CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei23 – 4321Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini44 – 5815LumenalSequence AnalysisAdd
BLAST
Transmembranei59 – 7921Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini80 – 9819CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei99 – 11921Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini120 – 15738LumenalSequence AnalysisAdd
BLAST
Transmembranei158 – 17821Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini179 – 23557CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • integral component of endoplasmic reticulum membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25883.

Polymorphism and mutation databases

BioMutaiDERL3.
DMDMi50400613.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 235235Derlin-3PRO_0000219048Add
BLAST

Proteomic databases

PaxDbiQ96Q80.
PRIDEiQ96Q80.

Expressioni

Tissue specificityi

Unlike DERL1 and DERL2, restricted to several tissues. Expressed at high levels in placenta, pancreas, spleen and small intestine.1 Publication

Inductioni

Up-regulated in response to endoplasmic reticulum stress via the ERN1-XBP1 pathway of the unfolded protein response (UPR).By similarity

Gene expression databases

BgeeiQ96Q80.
CleanExiHS_DERL3.
ExpressionAtlasiQ96Q80. baseline and differential.
GenevisibleiQ96Q80. HS.

Organism-specific databases

HPAiCAB037234.
HPA049306.

Interactioni

Subunit structurei

Forms homo- and heterooligomers with DERL2 and, to a lesser extent, with DERL1. Interacts with VCP, EDEM1, SELK and VIMP/SELS.2 Publications

Protein-protein interaction databases

BioGridi124816. 3 interactions.
STRINGi9606.ENSP00000384744.

Structurei

3D structure databases

ProteinModelPortaliQ96Q80.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the derlin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5291.
GeneTreeiENSGT00530000063156.
HOGENOMiHOG000200948.
HOVERGENiHBG051338.
InParanoidiQ96Q80.
KOiK13989.
OMAiGQALTVM.
OrthoDBiEOG73RBC2.
PhylomeDBiQ96Q80.
TreeFamiTF314715.

Family and domain databases

InterProiIPR007599. DER1.
[Graphical view]
PANTHERiPTHR11009. PTHR11009. 1 hit.
PfamiPF04511. DER1. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96Q80-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAWQGLAAEF LQVPAVTRAY TAACVLTTAA VQLELLSPFQ LYFNPHLVFR
60 70 80 90 100
KFQVWRLVTN FLFFGPLGFS FFFNMLFVFR YCRMLEEGSF RGRTADFVFM
110 120 130 140 150
FLFGGVLMTL LGLLGSLFFL GQALMAMLVY VWSRRSPRVR VNFFGLLTFQ
160 170 180 190 200
APFLPWALMG FSLLLGNSIL VDLLGIAVGH IYYFLEDVFP NQPGGKRLLQ
210 220 230
TPGFLKLLLD APAEDPNYLP LPEEQPGPHL PPPQQ
Length:235
Mass (Da):26,679
Last modified:July 19, 2004 - v2
Checksum:i2DC5F02487C4B824
GO
Isoform 2 (identifier: Q96Q80-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     206-235: KLLLDAPAEDPNYLPLPEEQPGPHLPPPQQ → GLQSSKAPAGSSLTIWTQQSQGGPGTAGELAAPS

Note: No experimental confirmation available.
Show »
Length:239
Mass (Da):26,605
Checksum:i7297772E29193957
GO
Isoform 3 (identifier: Q96Q80-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     206-235: KLLLDAPAEDPNYLPLPEEQPGPHLPPPQQ → LATAQQCPHRTGPSAGDFRAARPQLAVA

Note: No experimental confirmation available.
Show »
Length:233
Mass (Da):26,255
Checksum:i98A860411ED2C73B
GO
Isoform 4 (identifier: Q96Q80-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-74: Missing.
     110-205: LLGLLGSLFF...KRLLQTPGFL → VSFPQALEPR...LCSTRAPPHR

Note: No experimental confirmation available.
Show »
Length:225
Mass (Da):23,859
Checksum:i30576E135EC94D48
GO
Isoform 5 (identifier: Q96Q80-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     206-235: Missing.

Note: No experimental confirmation available.
Show »
Length:205
Mass (Da):23,382
Checksum:iE125D7D2EDBB8031
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti149 – 1491F → L.1 Publication
Corresponds to variant rs3177243 [ dbSNP | Ensembl ].
VAR_048897
Natural varianti211 – 2111A → V.1 Publication
Corresponds to variant rs1128127 [ dbSNP | Ensembl ].
VAR_019517

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 7474Missing in isoform 4. 1 PublicationVSP_011086Add
BLAST
Alternative sequencei110 – 20596LLGLL…TPGFL → VSFPQALEPRARAPRRPACV GPGANTAMPERDTVAVSSLV CVEGPLCAQLQGSGLDLQCC MQNTKPRTKEPGTVPALGAH GLLAAAGQLHPRGPAGDCGG PYLLLPGGRLPQPAWRQEAP ADPWLPVSVESPPSLSPPSE GSPPMGTCAGLCSTRAPPHR in isoform 4. 1 PublicationVSP_011087Add
BLAST
Alternative sequencei206 – 23530KLLLD…PPPQQ → GLQSSKAPAGSSLTIWTQQS QGGPGTAGELAAPS in isoform 2. 1 PublicationVSP_011088Add
BLAST
Alternative sequencei206 – 23530KLLLD…PPPQQ → LATAQQCPHRTGPSAGDFRA ARPQLAVA in isoform 3. CuratedVSP_011089Add
BLAST
Alternative sequencei206 – 23530Missing in isoform 5. 1 PublicationVSP_046330Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049213 Genomic DNA. Translation: BAB68409.1.
AL389876 mRNA. No translation available.
AK125830 mRNA. Translation: BAC86311.1.
CR456372 mRNA. Translation: CAG30258.1.
AP000350 Genomic DNA. No translation available.
BC057830 mRNA. Translation: AAH57830.1.
CCDSiCCDS33615.1. [Q96Q80-1]
CCDS42986.1. [Q96Q80-5]
CCDS46672.1. [Q96Q80-2]
RefSeqiNP_001002862.1. NM_001002862.2. [Q96Q80-1]
NP_001129223.1. NM_001135751.1. [Q96Q80-2]
NP_940842.2. NM_198440.3. [Q96Q80-5]
UniGeneiHs.593679.

Genome annotation databases

EnsembliENST00000318109; ENSP00000315303; ENSG00000099958. [Q96Q80-1]
ENST00000406855; ENSP00000384744; ENSG00000099958. [Q96Q80-2]
ENST00000476077; ENSP00000419399; ENSG00000099958. [Q96Q80-5]
ENST00000620697; ENSP00000483693; ENSG00000274437. [Q96Q80-2]
ENST00000628868; ENSP00000485763; ENSG00000274437. [Q96Q80-5]
ENST00000631305; ENSP00000486587; ENSG00000274437. [Q96Q80-1]
GeneIDi91319.
KEGGihsa:91319.
UCSCiuc002zyh.3. human. [Q96Q80-1]
uc002zyj.3. human. [Q96Q80-4]
uc002zyk.4. human. [Q96Q80-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049213 Genomic DNA. Translation: BAB68409.1.
AL389876 mRNA. No translation available.
AK125830 mRNA. Translation: BAC86311.1.
CR456372 mRNA. Translation: CAG30258.1.
AP000350 Genomic DNA. No translation available.
BC057830 mRNA. Translation: AAH57830.1.
CCDSiCCDS33615.1. [Q96Q80-1]
CCDS42986.1. [Q96Q80-5]
CCDS46672.1. [Q96Q80-2]
RefSeqiNP_001002862.1. NM_001002862.2. [Q96Q80-1]
NP_001129223.1. NM_001135751.1. [Q96Q80-2]
NP_940842.2. NM_198440.3. [Q96Q80-5]
UniGeneiHs.593679.

3D structure databases

ProteinModelPortaliQ96Q80.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124816. 3 interactions.
STRINGi9606.ENSP00000384744.

Polymorphism and mutation databases

BioMutaiDERL3.
DMDMi50400613.

Proteomic databases

PaxDbiQ96Q80.
PRIDEiQ96Q80.

Protocols and materials databases

DNASUi91319.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000318109; ENSP00000315303; ENSG00000099958. [Q96Q80-1]
ENST00000406855; ENSP00000384744; ENSG00000099958. [Q96Q80-2]
ENST00000476077; ENSP00000419399; ENSG00000099958. [Q96Q80-5]
ENST00000620697; ENSP00000483693; ENSG00000274437. [Q96Q80-2]
ENST00000628868; ENSP00000485763; ENSG00000274437. [Q96Q80-5]
ENST00000631305; ENSP00000486587; ENSG00000274437. [Q96Q80-1]
GeneIDi91319.
KEGGihsa:91319.
UCSCiuc002zyh.3. human. [Q96Q80-1]
uc002zyj.3. human. [Q96Q80-4]
uc002zyk.4. human. [Q96Q80-2]

Organism-specific databases

CTDi91319.
GeneCardsiGC22M024176.
HGNCiHGNC:14236. DERL3.
HPAiCAB037234.
HPA049306.
MIMi610305. gene.
neXtProtiNX_Q96Q80.
PharmGKBiPA25883.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5291.
GeneTreeiENSGT00530000063156.
HOGENOMiHOG000200948.
HOVERGENiHBG051338.
InParanoidiQ96Q80.
KOiK13989.
OMAiGQALTVM.
OrthoDBiEOG73RBC2.
PhylomeDBiQ96Q80.
TreeFamiTF314715.

Miscellaneous databases

GeneWikiiDerlin-3.
GenomeRNAii91319.
NextBioi77178.
PROiQ96Q80.
SOURCEiSearch...

Gene expression databases

BgeeiQ96Q80.
CleanExiHS_DERL3.
ExpressionAtlasiQ96Q80. baseline and differential.
GenevisibleiQ96Q80. HS.

Family and domain databases

InterProiIPR007599. DER1.
[Graphical view]
PANTHERiPTHR11009. PTHR11009. 1 hit.
PfamiPF04511. DER1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of a novel member of the NADH oxidoreductase complex I subunit homolog."
    Shimizu N., Minosima S., Kawasaki K., Sasaki T.
    Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 3).
  2. The European IMAGE consortium
    Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5), VARIANT LEU-149.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), VARIANT VAL-211.
    Tissue: Testis.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  5. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Placenta.
  7. "Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation."
    Oda Y., Okada T., Yoshida H., Kaufman R.J., Nagata K., Mori K.
    J. Cell Biol. 172:383-393(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, MEMBRANE TOPOLOGY, OLIGOMERIZATION, INTERACTION WITH VCP AND EDEM1.
  8. "Selenoprotein K binds multiprotein complexes and is involved in the regulation of endoplasmic reticulum homeostasis."
    Shchedrina V.A., Everley R.A., Zhang Y., Gygi S.P., Hatfield D.L., Gladyshev V.N.
    J. Biol. Chem. 286:42937-42948(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SELK AND VIMP.
  9. "STT3B-dependent posttranslational N-glycosylation as a surveillance system for secretory protein."
    Sato T., Sako Y., Sho M., Momohara M., Suico M.A., Shuto T., Nishitoh H., Okiyoneda T., Kokame K., Kaneko M., Taura M., Miyata M., Chosa K., Koga T., Morino-Koga S., Wada I., Kai H.
    Mol. Cell 47:99-110(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN ERAD PATHWAY.

Entry informationi

Entry nameiDERL3_HUMAN
AccessioniPrimary (citable) accession number: Q96Q80
Secondary accession number(s): F2Z3B6
, Q6ICJ6, Q6PEX0, Q6ZUB5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: June 24, 2015
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.