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Protein

Calcium and integrin-binding family member 3

Gene

CIB3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi116 – 127121CuratedAdd
BLAST
Calcium bindingi157 – 168122CuratedAdd
BLAST

GO - Molecular functioni

  • calcium ion binding Source: UniProtKB
  • magnesium ion binding Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Calcium, Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium and integrin-binding family member 3
Alternative name(s):
Kinase-interacting protein 3
Short name:
KIP 3
Gene namesi
Name:CIB3
Synonyms:KIP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:24580. CIB3.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134867741.

Polymorphism and mutation databases

BioMutaiCIB3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 187187Calcium and integrin-binding family member 3PRO_0000073536Add
BLAST

Proteomic databases

EPDiQ96Q77.
PaxDbiQ96Q77.
PRIDEiQ96Q77.

PTM databases

iPTMnetiQ96Q77.
PhosphoSiteiQ96Q77.

Expressioni

Gene expression databases

BgeeiQ96Q77.
CleanExiHS_CIB3.
ExpressionAtlasiQ96Q77. baseline and differential.
GenevisibleiQ96Q77. HS.

Organism-specific databases

HPAiHPA043553.

Interactioni

Subunit structurei

Interacts with ITGA2B (via C-terminus cytoplasmic tail region); the interaction is stabilized/increased in a calcium and magnesium-dependent manner.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
AESQ081173EBI-10292696,EBI-717810
BEND7Q8N7W2-23EBI-10292696,EBI-10181188
CCDC155Q8N6L03EBI-10292696,EBI-749265
ENOX2Q16206-23EBI-10292696,EBI-10179508
FLJ13057Q53SE73EBI-10292696,EBI-10172181
KLF17Q5JT823EBI-10292696,EBI-10292791
LNX1Q8TBB13EBI-10292696,EBI-739832
MEOX1P502213EBI-10292696,EBI-2864512
MEOX2A4D1273EBI-10292696,EBI-10172134
RELQ048643EBI-10292696,EBI-307352
SERTAD1Q53GC03EBI-10292696,EBI-2826300
SP4Q024463EBI-10292696,EBI-10198587
TACC3Q9Y6A53EBI-10292696,EBI-2554984
TRIM2Q9C0403EBI-10292696,EBI-749840
ZNF398Q8TD173EBI-10292696,EBI-8643207
ZNF426Q9BUY53EBI-10292696,EBI-743265

Protein-protein interaction databases

BioGridi125586. 16 interactions.
IntActiQ96Q77. 16 interactions.
STRINGi9606.ENSP00000269878.

Structurei

3D structure databases

ProteinModelPortaliQ96Q77.
SMRiQ96Q77. Positions 13-185.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini66 – 10136EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini103 – 13836EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini144 – 17936EF-hand 3PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 3 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0038. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00760000119179.
HOGENOMiHOG000233019.
HOVERGENiHBG107344.
InParanoidiQ96Q77.
OMAiKQTIFTP.
PhylomeDBiQ96Q77.
TreeFamiTF313865.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96Q77-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGNKQTVFTH EQLEAYQDCT FFTRKEIMRL FYRYQDLAPQ LVPLDYTTCP
60 70 80 90 100
DVKVPYELIG SMPELKDNPF RQRIAQVFSE DGDGHMTLDN FLDMFSVMSE
110 120 130 140 150
MAPRDLKAYY AFKIYDFNND DYICAWDLEQ TVTKLTRGGL SAEEVSLVCE
160 170 180
KVLDEADGDH DGRLSLEDFQ NMILRAPDFL STFHIRI
Length:187
Mass (Da):21,802
Last modified:May 18, 2010 - v3
Checksum:iFB32CCB46DF5ADCF
GO
Isoform 2 (identifier: Q96Q77-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     18-66: Missing.

Note: No experimental confirmation available.
Show »
Length:138
Mass (Da):15,974
Checksum:iFF5FCC37F877D1D0
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti139 – 1391G → E.1 Publication
Corresponds to variant rs6512087 [ dbSNP | Ensembl ].
VAR_060268

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei18 – 6649Missing in isoform 2. 1 PublicationVSP_055509Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB050868 mRNA. Translation: BAB71789.1.
AC020911 Genomic DNA. No translation available.
CH471106 Genomic DNA. Translation: EAW84535.1.
BC069428 mRNA. Translation: AAH69428.1.
BC112200 mRNA. Translation: AAI12201.1.
BC113591 mRNA. Translation: AAI13592.1.
CCDSiCCDS12340.1. [Q96Q77-1]
CCDS74305.1. [Q96Q77-2]
RefSeqiNP_001287851.1. NM_001300922.1. [Q96Q77-2]
NP_473454.1. NM_054113.3. [Q96Q77-1]
UniGeneiHs.255432.

Genome annotation databases

EnsembliENST00000269878; ENSP00000269878; ENSG00000141977. [Q96Q77-1]
ENST00000379859; ENSP00000369188; ENSG00000141977. [Q96Q77-2]
GeneIDi117286.
KEGGihsa:117286.
UCSCiuc002nds.4. human. [Q96Q77-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB050868 mRNA. Translation: BAB71789.1.
AC020911 Genomic DNA. No translation available.
CH471106 Genomic DNA. Translation: EAW84535.1.
BC069428 mRNA. Translation: AAH69428.1.
BC112200 mRNA. Translation: AAI12201.1.
BC113591 mRNA. Translation: AAI13592.1.
CCDSiCCDS12340.1. [Q96Q77-1]
CCDS74305.1. [Q96Q77-2]
RefSeqiNP_001287851.1. NM_001300922.1. [Q96Q77-2]
NP_473454.1. NM_054113.3. [Q96Q77-1]
UniGeneiHs.255432.

3D structure databases

ProteinModelPortaliQ96Q77.
SMRiQ96Q77. Positions 13-185.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125586. 16 interactions.
IntActiQ96Q77. 16 interactions.
STRINGi9606.ENSP00000269878.

PTM databases

iPTMnetiQ96Q77.
PhosphoSiteiQ96Q77.

Polymorphism and mutation databases

BioMutaiCIB3.

Proteomic databases

EPDiQ96Q77.
PaxDbiQ96Q77.
PRIDEiQ96Q77.

Protocols and materials databases

DNASUi117286.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000269878; ENSP00000269878; ENSG00000141977. [Q96Q77-1]
ENST00000379859; ENSP00000369188; ENSG00000141977. [Q96Q77-2]
GeneIDi117286.
KEGGihsa:117286.
UCSCiuc002nds.4. human. [Q96Q77-1]

Organism-specific databases

CTDi117286.
GeneCardsiCIB3.
HGNCiHGNC:24580. CIB3.
HPAiHPA043553.
MIMi610645. gene.
neXtProtiNX_Q96Q77.
PharmGKBiPA134867741.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0038. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00760000119179.
HOGENOMiHOG000233019.
HOVERGENiHBG107344.
InParanoidiQ96Q77.
OMAiKQTIFTP.
PhylomeDBiQ96Q77.
TreeFamiTF313865.

Miscellaneous databases

GenomeRNAii117286.
PROiQ96Q77.
SOURCEiSearch...

Gene expression databases

BgeeiQ96Q77.
CleanExiHS_CIB3.
ExpressionAtlasiQ96Q77. baseline and differential.
GenevisibleiQ96Q77. HS.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Hayashi A., Okaze H., Kozuma S., Saito T.
    Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT GLU-139.
  5. "Biophysical and structural studies of the human calcium- and integrin-binding protein family: understanding their functional similarities and differences."
    Huang H., Bogstie J.N., Vogel H.J.
    Biochem. Cell Biol. 90:646-656(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ITGA2B, MAGNESIUM-BINDING, CALCIUM-BINDING.

Entry informationi

Entry nameiCIB3_HUMAN
AccessioniPrimary (citable) accession number: Q96Q77
Secondary accession number(s): E7EUX1, Q2M1W0, Q6ISP1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: May 18, 2010
Last modified: June 8, 2016
This is version 105 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The binding of either calcium or magnesium significantly increases the structural stability of the protein in comparison to apo-CIB (calcium- and magnesium-free form).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.