Q96Q40 (CDK15_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cyclin-dependent kinase 15
EC=2.7.11.22

Alternative name(s):
Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein
Cell division protein kinase 15
Serine/threonine-protein kinase ALS2CR7
Serine/threonine-protein kinase PFTAIRE-2

Gene names

Name:	CDK15
Synonyms:	ALS2CR7, PFTK2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	435 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin By similarity.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Cofactor	Magnesium By similarity.
Sequence similarities	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Contains 1 protein kinase domain.
Sequence caution	The sequence BAD18656.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW cyclin-dependent protein kinase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96Q40-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96Q40-2)

The sequence of this isoform differs from the canonical sequence as follows:
     182-202: Missing.
     337-422: EWFPLPTPRS...PEMCDLLASY → GGSKKQHGWHTDIGQHRTAAMQPCSRNVSF

Note: No experimental confirmation available.

Isoform 3 (identifier: Q96Q40-3)

The sequence of this isoform differs from the canonical sequence as follows:
     401-435: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q96Q40-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-51: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 435	435	Cyclin-dependent kinase 15		PRO_0000085619
Regions
	Domain	103 – 387	285	Protein kinase
	Nucleotide binding	109 – 117	9	ATP By similarity
Sites
	Active site	224	1	Proton acceptor By similarity
	Binding site	132	1	ATP By similarity
Natural variations
	Alternative sequence	1 – 51	51	Missing in isoform 4.		VSP_038765
	Alternative sequence	182 – 202	21	Missing in isoform 2.		VSP_023743
	Alternative sequence	337 – 422	86	EWFPL…LLASY → GGSKKQHGWHTDIGQHRTAA MQPCSRNVSF in isoform 2.		VSP_023744
	Alternative sequence	401 – 435	35	Missing in isoform 3.		VSP_023745
	Natural variant	64	1	R → G. Ref.7 Corresponds to variant rs34776344 [ dbSNP | Ensembl ].		VAR_042016
	Natural variant	93	1	K → E in a renal clear cell carcinoma sample; somatic mutation. Ref.7		VAR_042017
	Natural variant	127	1	Q → R. Ref.7 Corresponds to variant rs56135556 [ dbSNP | Ensembl ].		VAR_042018
	Natural variant	255	1	T → I. Ref.7 Corresponds to variant rs34851370 [ dbSNP | Ensembl ].		VAR_042019
	Natural variant	276	1	E → D in a breast infiltrating ductal carcinoma sample; somatic mutation. Ref.7		VAR_042020

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 2, 2010. Version 2. Checksum: B415BBBE322EAB33	FASTA	435	49,023
	10 20 30 40 50 60 MGQELCAKTV QPGCSCYHCS EGGEAHSCRR SQPETTEAAF KLTDLKEASC SMTSFHPRGL 70 80 90 100 110 120 QAARAQKFKS KRPRSNSDCF QEEDLRQGFQ WRKSLPFGAA SSYLNLEKLG EGSYATVYKG 130 140 150 160 170 180 ISRINGQLVA LKVISMNAEE GVPFTAIREA SLLKGLKHAN IVLLHDIIHT KETLTFVFEY 190 200 210 220 230 240 MHTDLAQYMS QHPGGLHPHN VRLFMFQLLR GLAYIHHQHV LHRDLKPQNL LISHLGELKL 250 260 270 280 290 300 ADFGLARAKS IPSQTYSSEV VTLWYRPPDA LLGATEYSSE LDIWGAGCIF IEMFQGQPLF 310 320 330 340 350 360 PGVSNILEQL EKIWEVLGVP TEDTWPGVSK LPNYNPEWFP LPTPRSLHVV WNRLGRVPEA 370 380 390 400 410 420 EDLASQMLKG FPRDRVSAQE ALVHDYFSAL PSQLYQLPDE ESLFTVSGVR LKPEMCDLLA 430 SYQKGHHPAQ FSKCW
	Isoform 2 [UniParc]. Checksum: D38225492BE5B30B	FASTA	358	40,122
	10 20 30 40 50 60 MGQELCAKTV QPGCSCYHCS EGGEAHSCRR SQPETTEAAF KLTDLKEASC SMTSFHPRGL 70 80 90 100 110 120 QAARAQKFKS KRPRSNSDCF QEEDLRQGFQ WRKSLPFGAA SSYLNLEKLG EGSYATVYKG 130 140 150 160 170 180 ISRINGQLVA LKVISMNAEE GVPFTAIREA SLLKGLKHAN IVLLHDIIHT KETLTFVFEY 190 200 210 220 230 240 MLFMFQLLRG LAYIHHQHVL HRDLKPQNLL ISHLGELKLA DFGLARAKSI PSQTYSSEVV 250 260 270 280 290 300 TLWYRPPDAL LGATEYSSEL DIWGAGCIFI EMFQGQPLFP GVSNILEQLE KIWEVLGVPT 310 320 330 340 350 EDTWPGVSKL PNYNPGGSKK QHGWHTDIGQ HRTAAMQPCS RNVSFQKGHH PAQFSKCW
	Isoform 3 [UniParc]. Checksum: AE9AD984E40A3BF6	FASTA	400	45,046
	10 20 30 40 50 60 MGQELCAKTV QPGCSCYHCS EGGEAHSCRR SQPETTEAAF KLTDLKEASC SMTSFHPRGL 70 80 90 100 110 120 QAARAQKFKS KRPRSNSDCF QEEDLRQGFQ WRKSLPFGAA SSYLNLEKLG EGSYATVYKG 130 140 150 160 170 180 ISRINGQLVA LKVISMNAEE GVPFTAIREA SLLKGLKHAN IVLLHDIIHT KETLTFVFEY 190 200 210 220 230 240 MHTDLAQYMS QHPGGLHPHN VRLFMFQLLR GLAYIHHQHV LHRDLKPQNL LISHLGELKL 250 260 270 280 290 300 ADFGLARAKS IPSQTYSSEV VTLWYRPPDA LLGATEYSSE LDIWGAGCIF IEMFQGQPLF 310 320 330 340 350 360 PGVSNILEQL EKIWEVLGVP TEDTWPGVSK LPNYNPEWFP LPTPRSLHVV WNRLGRVPEA 370 380 390 400 EDLASQMLKG FPRDRVSAQE ALVHDYFSAL PSQLYQLPDE
	Isoform 4 [UniParc]. Checksum: 6CAAD08E6E0E43EB	FASTA	384	43,574
	10 20 30 40 50 60 MTSFHPRGLQ AARAQKFKSK RPRSNSDCFQ EEDLRQGFQW RKSLPFGAAS SYLNLEKLGE 70 80 90 100 110 120 GSYATVYKGI SRINGQLVAL KVISMNAEEG VPFTAIREAS LLKGLKHANI VLLHDIIHTK 130 140 150 160 170 180 ETLTFVFEYM HTDLAQYMSQ HPGGLHPHNV RLFMFQLLRG LAYIHHQHVL HRDLKPQNLL 190 200 210 220 230 240 ISHLGELKLA DFGLARAKSI PSQTYSSEVV TLWYRPPDAL LGATEYSSEL DIWGAGCIFI 250 260 270 280 290 300 EMFQGQPLFP GVSNILEQLE KIWEVLGVPT EDTWPGVSKL PNYNPEWFPL PTPRSLHVVW 310 320 330 340 350 360 NRLGRVPEAE DLASQMLKGF PRDRVSAQEA LVHDYFSALP SQLYQLPDEE SLFTVSGVRL 370 380 KPEMCDLLAS YQKGHHPAQF SKCW

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2." Hadano S., Hand C.K., Osuga H., Yanagisawa Y., Otomo A., Devon R.S., Miyamoto N., Showguchi-Miyata J., Okada Y., Singaraja R., Figlewicz D.A., Kwiatkowski T., Hosler B.A., Sagie T., Skaug J., Nasir J., Brown R.H. Jr., Scherer S.W. , Rouleau G.A., Hayden M.R., Ikeda J.-E. Nat. Genet. 29:166-173(2001) [PubMed: 11586298] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4). Tissue: Testis.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4). Tissue: Glial tumor and Testis.
[3]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed: 15815621] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Brain.
[6]	"The protein kinase complement of the human genome." Manning G., Whyte D.B., Martinez R., Hunter T., Sudarsanam S. Science 298:1912-1934(2002) [PubMed: 12471243] [Abstract] Cited for: NOMENCLATURE.
[7]	"Patterns of somatic mutation in human cancer genomes." Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R. Nature 446:153-158(2007) [PubMed: 17344846] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] GLY-64; GLU-93; ARG-127; ILE-255 AND ASP-276.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB053308 mRNA. Translation: BAB69017.1. AK131512 mRNA. Translation: BAD18656.1. Different initiation. AK292434 mRNA. Translation: BAF85123.1. AC007242 Genomic DNA. Translation: AAX93182.1. AC007358 Genomic DNA. Translation: AAX88914.1. CH471063 Genomic DNA. Translation: EAW70295.1. CH471063 Genomic DNA. Translation: EAW70297.1. BC038807 mRNA. Translation: AAH38807.1.
IPI	IPI00044678. IPI00442058. IPI00829793. IPI00955397.
RefSeq	NP_631897.1. NM_139158.1.
UniGene	Hs.348711.
3D structure databases
ProteinModelPortal	Q96Q40.
SMR	Q96Q40. Positions 100-431.
ModBase	Search...
PTM databases
PhosphoSite	Q96Q40.
Polymorphism databases
DMDM	290457634.
Proteomic databases
PRIDE	Q96Q40.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000260967; ENSP00000260967; ENSG00000138395. ENST00000410091; ENSP00000386901; ENSG00000138395.
GeneID	65061.
KEGG	hsa:65061.
UCSC	uc002uys.2. human. uc002uyt.2. human. uc010fto.1. human.
Organism-specific databases
CTD	65061.
GeneCards	GC02P202656.
H-InvDB	HIX0002745.
HGNC	HGNC:14434. CDK15.
HPA	HPA015786.
neXtProt	NX_Q96Q40.
PharmGKB	PA162399234. PA165696414.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG11600.
GeneTree	ENSGT00600000083998.
HOVERGEN	HBG014652.
InParanoid	Q96Q40.
OMA	LKPEMCD.
PhylomeDB	Q96Q40.
Enzyme and pathway databases
BRENDA	2.7.11.22. 2681.
Gene expression databases
ArrayExpress	Q96Q40.
Bgee	Q96Q40.
CleanEx	HS_PFTK2.
Genevestigator	Q96Q40.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_kinase-like_dom. IPR008271. Ser/Thr_kinase_AS. IPR002290. Ser/Thr_kinase_dom. [Graphical view]
KO	K15594.
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other
DrugBank	DB00171. Adenosine triphosphate.
NextBio	67244.

Entry information

Entry name

CDK15_HUMAN

Accession

Primary (citable) accession number: Q96Q40
Secondary accession number(s): A8K8R9 , B8ZZX0, C9J1N8, C9K003, Q4ZG86, Q53TV1, Q6ZMR9, Q8IUP1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 19, 2002
Last sequence update:	March 2, 2010
Last modified:	January 25, 2012
This is version 93 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.