Q96Q15 (SMG1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serine/threonine-protein kinase SMG1
Short name=SMG-1
Short name=hSMG-1
EC=2.7.11.1

Alternative name(s):
61E3.4
Lambda/iota protein kinase C-interacting protein
Short name=Lambda-interacting protein

Gene names

Name:	SMG1
Synonyms:	ATX, KIAA0421, LIP

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	3661 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q. Plays a central role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1. Recruited by release factors to stalled ribosomes together with SMG8 and SMG9 (forming the SMG1C protein kinase complex), and UPF1 to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Also acts as a genotoxic stress-activated protein kinase that displays some functional overlap with ATM. Can phosphorylate p53/TP53 and is required for optimal p53/TP53 activation after cellular exposure to genotoxic stress. Its depletion leads to spontaneous DNA damage and increased sensitivity to ionizing radiation (IR). May activate PRKCI but not PRKCZ. Ref.2 Ref.3 Ref.4 Ref.12
Catalytic activity	ATP + a protein = ADP + a phosphoprotein. Ref.16
Cofactor	Manganese. Ref.3
Enzyme regulation	Inhibited by caffeine, LY294002 and wortmannin. Ref.2 Ref.3 Ref.4
Subunit structure	Component of the SMG1C complex composed of SMG1, SMG8 and SMG9; the recruitment of SMG8 to SMG1 N-terminus induces a large conformational change in the SMG1 C-terminal head domain containing the catalytic domain. Component of the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. Interacts with PRKCI. Interacts with TELO2 and TTI1. Interacts with RUVBL1 and RUVBL2. Interacts with UPF2. Ref.2 Ref.8 Ref.10 Ref.11 Ref.12 Ref.16 Ref.19 Ref.20 Ref.21 Ref.24
Subcellular location	Nucleus. Cytoplasm Ref.4.
Tissue specificity	Widely expressed, with highest level in heart and skeletal muscle. Expressed in placenta, brain, lung and spleen, but not in liver. Ref.4 Ref.8
Post-translational modification	Autophosphorylated Probable. Ref.2 Ref.3 Ref.4
Miscellaneous	This gene is located in a region of chromosome 16 that contains 2 segmental duplications. Other genes that are highly related to this exist, but they probably represent pseudogenes.
Sequence similarities	Belongs to the PI3/PI4-kinase family. Contains 1 FAT domain. Contains 1 FATC domain. Contains 1 HEAT repeat. Contains 1 PI3K/PI4K domain.
Sequence caution	The sequence AAA86535.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Biological process	DNA damage DNA repair Nonsense-mediated mRNA decay
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	ATP-binding Manganese Metal-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA repair Inferred from electronic annotation. Source: UniProtKB-KW gene expression Traceable author statement. Source: Reactome mRNA export from nucleus Traceable author statement PubMed 16488880. Source: UniProtKB nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Inferred from direct assay Ref.2. Source: UniProtKB peptidyl-serine phosphorylation Inferred from direct assay Ref.2Ref.4. Source: UniProtKB phosphatidylinositol phosphorylation Inferred from direct assay Ref.3. Source: UniProtKB protein autophosphorylation Inferred from direct assay Ref.3Ref.2. Source: UniProtKB response to stress Inferred from direct assay Ref.4. Source: UniProtKB
Cellular_component	cytosol Traceable author statement. Source: Reactome nucleus Inferred from direct assay Ref.10Ref.4. Source: UniProtKB
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from direct assay Ref.2Ref.4Ref.16. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
PABPC1	P11940	2	EBI-1049832,EBI-81531
UPF2	Q9HAU5	6	EBI-1049832,EBI-372073

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96Q15-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96Q15-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-140: Missing.

Isoform 3 (identifier: Q96Q15-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-630: Missing.

Isoform 4 (identifier: Q96Q15-4)

Also known as: BLIP;

The sequence of this isoform differs from the canonical sequence as follows:
     1-1269: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 3661	3661	Serine/threonine-protein kinase SMG1		PRO_0000229791
Regions
	Domain	1131 – 1866	736	FAT
	Repeat	1817 – 1852	36	HEAT
	Domain	2150 – 2478	329	PI3K/PI4K
	Domain	3629 – 3661	33	FATC
	Region	1 – 1977	1977	Interaction with SMG8 and SMG9
Amino acid modifications
	Modified residue	173	1	N6-acetyllysine Ref.18
	Modified residue	3550	1	Phosphothreonine Ref.14
	Modified residue	3556	1	Phosphoserine Ref.14
	Modified residue	3570	1	Phosphoserine Ref.15
	Modified residue	3573	1	Phosphothreonine Ref.22
	Modified residue	3577	1	Phosphothreonine By similarity
Natural variations
	Alternative sequence	1 – 1269	1269	Missing in isoform 4.		VSP_017746
	Alternative sequence	1 – 630	630	Missing in isoform 3.		VSP_017747
	Alternative sequence	1 – 140	140	Missing in isoform 2.		VSP_017748
	Natural variant	35	1	A → T. Ref.26		VAR_041623
	Natural variant	126	1	R → C. Ref.26		VAR_041624
	Natural variant	144	1	S → C. Ref.4 Ref.26		VAR_041625
	Natural variant	151	1	N → Y. Ref.26		VAR_041626
	Natural variant	160	1	D → N. Ref.26		VAR_041627
	Natural variant	167	1	A → V. Ref.26		VAR_041628
	Natural variant	320	1	D → G. Ref.26		VAR_041629
	Natural variant	465	1	G → S. Ref.26		VAR_041630
	Natural variant	546	1	H → R. Ref.26		VAR_041631
	Natural variant	588	1	A → S. Ref.26		VAR_041632
	Natural variant	612	1	I → K. Ref.4 Ref.26		VAR_041633
	Natural variant	753	1	S → C. Ref.26		VAR_041634
	Natural variant	809	1	S → C. Ref.26		VAR_041635
	Natural variant	812	1	R → C. Ref.26		VAR_041636
	Natural variant	829	1	V → I. Ref.26		VAR_041637
	Natural variant	832	1	N → D. Ref.26		VAR_041638
	Natural variant	952	1	A → G. Ref.26		VAR_041639
	Natural variant	969	1	N → S. Ref.26		VAR_041640
	Natural variant	1016	1	F → L. Ref.26		VAR_041641
	Natural variant	1029	1	R → Q. Ref.26		VAR_041642
	Natural variant	1072	1	T → S. Ref.26		VAR_041643
	Natural variant	1103	1	N → H. Ref.26		VAR_041644
	Natural variant	1275	1	P → R. Ref.26		VAR_041645
	Natural variant	1292	1	Q → P. Ref.26		VAR_041646
	Natural variant	1332	1	I → V. Ref.26		VAR_041647
	Natural variant	1358	1	S → P. Ref.26		VAR_041648
	Natural variant	1418	1	R → T. Ref.26		VAR_041649
	Natural variant	2171	1	S → C in a breast pleomorphic lobular carcinoma sample; somatic mutation. Ref.26		VAR_041650
	Natural variant	2258	1	G → S. Ref.26		VAR_041651
	Natural variant	2345	1	M → K. Ref.26		VAR_041652
	Natural variant	2730	1	Q → E. Ref.26		VAR_041653
	Natural variant	2889	1	G → S. Ref.26		VAR_041654
	Natural variant	2899	1	P → A. Ref.26		VAR_041655
	Natural variant	3239	1	I → T in a breast infiltrating ductal carcinoma sample; somatic mutation. Ref.26		VAR_041656
	Natural variant	3583	1	K → Q in a breast infiltrating ductal carcinoma sample; somatic mutation. Ref.26		VAR_041657
Experimental info
	Mutagenesis	2335	1	D → A: Loss of function. Ref.2 Ref.3 Ref.4
	Sequence conflict	14	1	G → GGGGG in BAB70696. Ref.2
	Sequence conflict	20	1	K → N in BAB70696. Ref.2
	Sequence conflict	22	1	P → S in BAB70696. Ref.2
	Sequence conflict	40	1	D → G in BAB70696. Ref.2
	Sequence conflict	686	1	S → A in BAB70696. Ref.2
	Sequence conflict	743	1	K → R in BAB70696. Ref.2
	Sequence conflict	1193	1	C → F in BAB70696. Ref.2
	Sequence conflict	2009	1	K → R in BAB70696. Ref.2
	Sequence conflict	2077	1	S → N in AAK58892. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified February 8, 2011. Version 3. Checksum: 216A55F3121F5829	FASTA	3,661	410,501
	10 20 30 40 50 60 MSRRAPGSRL SSGGGGGGTK YPRSWNDWQP RTDSASADPD NLKYSSSRDR GGSSSYGLQP 70 80 90 100 110 120 SNSAVVSRQR HDDTRVHADI QNDEKGGYSV NGGSGENTYG RKSLGQELRV NNVTSPEFTS 130 140 150 160 170 180 VQHGSRALAT KDMRKSQERS MSYSDESRLS NLLRRITRED DRDRRLATVK QLKEFIQQPE 190 200 210 220 230 240 NKLVLVKQLD NILAAVHDVL NESSKLLQEL RQEGACCLGL LCASLSYEAE KIFKWIFSKF 250 260 270 280 290 300 SSSAKDEVKL LYLCATYKAL ETVGEKKAFS SVMQLVMTSL QSILENVDTP ELLCKCVKCI 310 320 330 340 350 360 LLVARCYPHI FSTNFRDTVD ILVGWHIDHT QKPSLTQQVS GWLQSLEPFW VADLAFSTTL 370 380 390 400 410 420 LGQFLEDMEA YAEDLSHVAS GESVDEDVPP PSVSLPKLAA LLRVFSTVVR SIGERFSPIR 430 440 450 460 470 480 GPPITEAYVT DVLYRVMRCV TAANQVFFSE AVLTAANECV GVLLGSLDPS MTIHCDMVIT 490 500 510 520 530 540 YGLDQLENCQ TCGTDYIISV LNLLTLIVEQ INTKLPSSFV EKLFIPSSKL LFLRYHKEKE 550 560 570 580 590 600 VVAVAHAVYQ AVLSLKNIPV LETAYKLILG EMTCALNNLL HSLQLPEACS EIKHEAFKNH 610 620 630 640 650 660 VFNVDNAKFV VIFDLSALTT IGNAKNSLIG MWALSPTVFA LLSKNLMIVH SDLAVHFPAI 670 680 690 700 710 720 QYAVLYTLYS HCTRHDHFIS SSLSSSSPSL FDGAVISTVT TATKKHFSII LNLLGILLKK 730 740 750 760 770 780 DNLNQDTRKL LMTWALEAAV LMKKSETYAP LFSLPSFHKF CKGLLANTLV EDVNICLQAC 790 800 810 820 830 840 SSLHALSSSL PDDLLQRCVD VCRVQLVHSG TRIRQAFGKL LKSIPLDVVL SNNNHTEIQE 850 860 870 880 890 900 ISLALRSHMS KAPSNTFHPQ DFSDVISFIL YGNSHRTGKD NWLERLFYSC QRLDKRDQST 910 920 930 940 950 960 IPRNLLKTDA VLWQWAIWEA AQFTVLSKLR TPLGRAQDTF QTIEGIIRSL AAHTLNPDQD 970 980 990 1000 1010 1020 VSQWTTADND EGHGNNQLRL VLLLQYLENL EKLMYNAYEG CANALTSPPK VIRTFFYTNR 1030 1040 1050 1060 1070 1080 QTCQDWLTRI RLSIMRVGLL AGQPAVTVRH GFDLLTEMKT TSLSQGNELE VTIMMVVEAL 1090 1100 1110 1120 1130 1140 CELHCPEAIQ GIAVWSSSIV GKNLLWINSV AQQAEGRFEK ASVEYQEHLC AMTGVDCCIS 1150 1160 1170 1180 1190 1200 SFDKSVLTLA NAGRNSASPK HSLNGESRKT VLSKPTDSSP EVINYLGNKA CECYISIADW 1210 1220 1230 1240 1250 1260 AAVQEWQNAI HDLKKSTSST SLNLKADFNY IKSLSSFESG KFVECTEQLE LLPGENINLL 1270 1280 1290 1300 1310 1320 AGGSKEKIDM KKLLPNMLSP DPRELQKSIE VQLLRSSVCL ATALNPIEQD QKWQSITENV 1330 1340 1350 1360 1370 1380 VKYLKQTSRI AIGPLRLSTL TVSQSLPVLS TLQLYCSSAL ENTVSNRLST EDCLIPLFSE 1390 1400 1410 1420 1430 1440 ALRSCKQHDV RPWMQALRYT MYQNQLLEKI KEQTVPIRSH LMELGLTAAK FARKRGNVSL 1450 1460 1470 1480 1490 1500 ATRLLAQCSE VQLGKTTTAQ DLVQHFKKLS TQGQVDEKWG PELDIEKTKL LYTAGQSTHA 1510 1520 1530 1540 1550 1560 MEMLSSCAIS FCKSVKAEYA VAKSILTLAK WIQAEWKEIS GQLKQVYRAQ HQQNFTGLST 1570 1580 1590 1600 1610 1620 LSKNILTLIE LPSVNTMEEE YPRIESESTV HIGVGEPDFI LGQLYHLSSV QAPEVAKSWA 1630 1640 1650 1660 1670 1680 ALASWAYRWG RKVVDNASQG EGVRLLPREK SEVQNLLPDT ITEEEKERIY GILGQAVCRP 1690 1700 1710 1720 1730 1740 AGIQDEDITL QITESEDNEE DDMVDVIWRQ LISSCPWLSE LDESATEGVI KVWRKVVDRI 1750 1760 1770 1780 1790 1800 FSLYKLSCSA YFTFLKLNAG QIPLDEDDPR LHLSHRVEQS TDDMIVMATL RLLRLLVKHA 1810 1820 1830 1840 1850 1860 GELRQYLEHG LETTPTAPWR GIIPQLFSRL NHPEVYVRQS ICNLLCRVAQ DSPHLILYPA 1870 1880 1890 1900 1910 1920 IVGTISLSSE SQASGNKFST AIPTLLGNIQ GEELLVSECE GGSPPASQDS NKDEPKSGLN 1930 1940 1950 1960 1970 1980 EDQAMMQDCY SKIVDKLSSA NPTMVLQVQM LVAELRRVTV LWDELWLGVL LQQHMYVLRR 1990 2000 2010 2020 2030 2040 IQQLEDEVKR VQNNNTLRKE EKIAIMREKH TALMKPIVFA LEHVRSITAA PAETPHEKWF 2050 2060 2070 2080 2090 2100 QDNYGDAIEN ALEKLKTPLN PAKPGSSWIP FKEIMLSLQQ RAQKRASYIL RLEEISPWLA 2110 2120 2130 2140 2150 2160 AMTNTEIALP GEVSARDTVT IHSVGGTITI LPTKTKPKKL LFLGSDGKSY PYLFKGLEDL 2170 2180 2190 2200 2210 2220 HLDERIMQFL SIVNTMFATI NRQETPRFHA RHYSVTPLGT RSGLIQWVDG ATPLFGLYKR 2230 2240 2250 2260 2270 2280 WQQREAALQA QKAQDSYQTP QNPGIVPRPS ELYYSKIGPA LKTVGLSLDV SRRDWPLHVM 2290 2300 2310 2320 2330 2340 KAVLEELMEA TPPNLLAKEL WSSCTTPDEW WRVTQSYARS TAVMSMVGYI IGLGDRHLDN 2350 2360 2370 2380 2390 2400 VLIDMTTGEV VHIDYNVCFE KGKSLRVPEK VPFRMTQNIE TALGVTGVEG VFRLSCEQVL 2410 2420 2430 2440 2450 2460 HIMRRGRETL LTLLEAFVYD PLVDWTAGGE AGFAGAVYGG GGQQAESKQS KREMEREITR 2470 2480 2490 2500 2510 2520 SLFSSRVAEI KVNWFKNRDE MLVVLPKLDG SLDEYLSLQE QLTDVEKLQG KLLEEIEFLE 2530 2540 2550 2560 2570 2580 GAEGVDHPSH TLQHRYSEHT QLQTQQRAVQ EAIQVKLNEF EQWITHYQAA FNNLEATQLA 2590 2600 2610 2620 2630 2640 SLLQEISTQM DLGPPSYVPA TAFLQNAGQA HLISQCEQLE GEVGALLQQR RSVLRGCLEQ 2650 2660 2670 2680 2690 2700 LHHYATVALQ YPKAIFQKHR IEQWKTWMEE LICNTTVERC QELYRKYEMQ YAPQPPPTVC 2710 2720 2730 2740 2750 2760 QFITATEMTL QRYAADINSR LIRQVERLKQ EAVTVPVCED QLKEIERCIK VFLHENGEEG 2770 2780 2790 2800 2810 2820 SLSLASVIIS ALCTLTRRNL MMEGAASSAG EQLVDLTSRD GAWFLEELCS MSGNVTCLVQ 2830 2840 2850 2860 2870 2880 LLKQCHLVPQ DLDIPNPMEA SETVHLANGV YTSLQELNSN FRQIIFPEAL RCLMKGEYTL 2890 2900 2910 2920 2930 2940 ESMLHELDGL IEQTTDGVPL QTLVESLQAY LRNAAMGLEE ETHAHYIDVA RLLHAQYGEL 2950 2960 2970 2980 2990 3000 IQPRNGSVDE TPKMSAGQML LVAFDGMFAQ VETAFSLLVE KLNKMEIPIA WRKIDIIREA 3010 3020 3030 3040 3050 3060 RSTQVNFFDD DNHRQVLEEI FFLKRLQTIK EFFRLCGTFS KTLSGSSSLE DQNTVNGPVQ 3070 3080 3090 3100 3110 3120 IVNVKTLFRN SCFSEDQMAK PIKAFTADFV RQLLIGLPNQ ALGLTLCSFI SALGVDIIAQ 3130 3140 3150 3160 3170 3180 VEAKDFGAES KVSVDDLCKK AVEHNIQIGK FSQLVMNRAT VLASSYDTAW KKHDLVRRLE 3190 3200 3210 3220 3230 3240 TSISSCKTSL QRVQLHIAMF QWQHEDLLIN RPQAMSVTPP PRSAILTSMK KKLHTLSQIE 3250 3260 3270 3280 3290 3300 TSIATVQEKL AALESSIEQR LKWAGGANPA LAPVLQDFEA TIAERRNLVL KESQRASQVT 3310 3320 3330 3340 3350 3360 FLCSNIIHFE SLRTRTAEAL NLDAALFELI KRCQQMCSFA SQFNSSVSEL ELRLLQRVDT 3370 3380 3390 3400 3410 3420 GLEHPIGSSE WLLSAHKQLT QDMSTQRAIQ TEKEQQIETV CETIQNLVDN IKTVLTGHNR 3430 3440 3450 3460 3470 3480 QLGDVKHLLK AMAKDEEAAL ADGEDVPYEN SVRQFLGEYK SWQDNIQTVL FTLVQAMGQV 3490 3500 3510 3520 3530 3540 RSQEHVEMLQ EITPTLKELK TQSQSIYNNL VSFASPLVTD ATNECSSPTS SATYQPSFAA 3550 3560 3570 3580 3590 3600 AVRSNTGQKT QPDVMSQNAR KLIQKNLATS ADTPPSTVPG TGKSVACSPK KAVRDPKTGK 3610 3620 3630 3640 3650 3660 AVQERNSYAV SVWKRVKAKL EGRDVDPNRR MSVAEQVDYV IKEATNLDNL AQLYEGWTAW V
	Isoform 2 [UniParc]. Checksum: C2DDDEEA77C6D976	FASTA	3,521	395,382
	10 20 30 40 50 60 MSYSDESRLS NLLRRITRED DRDRRLATVK QLKEFIQQPE NKLVLVKQLD NILAAVHDVL 70 80 90 100 110 120 NESSKLLQEL RQEGACCLGL LCASLSYEAE KIFKWIFSKF SSSAKDEVKL LYLCATYKAL 130 140 150 160 170 180 ETVGEKKAFS SVMQLVMTSL QSILENVDTP ELLCKCVKCI LLVARCYPHI FSTNFRDTVD 190 200 210 220 230 240 ILVGWHIDHT QKPSLTQQVS GWLQSLEPFW VADLAFSTTL LGQFLEDMEA YAEDLSHVAS 250 260 270 280 290 300 GESVDEDVPP PSVSLPKLAA LLRVFSTVVR SIGERFSPIR GPPITEAYVT DVLYRVMRCV 310 320 330 340 350 360 TAANQVFFSE AVLTAANECV GVLLGSLDPS MTIHCDMVIT YGLDQLENCQ TCGTDYIISV 370 380 390 400 410 420 LNLLTLIVEQ INTKLPSSFV EKLFIPSSKL LFLRYHKEKE VVAVAHAVYQ AVLSLKNIPV 430 440 450 460 470 480 LETAYKLILG EMTCALNNLL HSLQLPEACS EIKHEAFKNH VFNVDNAKFV VIFDLSALTT 490 500 510 520 530 540 IGNAKNSLIG MWALSPTVFA LLSKNLMIVH SDLAVHFPAI QYAVLYTLYS HCTRHDHFIS 550 560 570 580 590 600 SSLSSSSPSL FDGAVISTVT TATKKHFSII LNLLGILLKK DNLNQDTRKL LMTWALEAAV 610 620 630 640 650 660 LMKKSETYAP LFSLPSFHKF CKGLLANTLV EDVNICLQAC SSLHALSSSL PDDLLQRCVD 670 680 690 700 710 720 VCRVQLVHSG TRIRQAFGKL LKSIPLDVVL SNNNHTEIQE ISLALRSHMS KAPSNTFHPQ 730 740 750 760 770 780 DFSDVISFIL YGNSHRTGKD NWLERLFYSC QRLDKRDQST IPRNLLKTDA VLWQWAIWEA 790 800 810 820 830 840 AQFTVLSKLR TPLGRAQDTF QTIEGIIRSL AAHTLNPDQD VSQWTTADND EGHGNNQLRL 850 860 870 880 890 900 VLLLQYLENL EKLMYNAYEG CANALTSPPK VIRTFFYTNR QTCQDWLTRI RLSIMRVGLL 910 920 930 940 950 960 AGQPAVTVRH GFDLLTEMKT TSLSQGNELE VTIMMVVEAL CELHCPEAIQ GIAVWSSSIV 970 980 990 1000 1010 1020 GKNLLWINSV AQQAEGRFEK ASVEYQEHLC AMTGVDCCIS SFDKSVLTLA NAGRNSASPK 1030 1040 1050 1060 1070 1080 HSLNGESRKT VLSKPTDSSP EVINYLGNKA CECYISIADW AAVQEWQNAI HDLKKSTSST 1090 1100 1110 1120 1130 1140 SLNLKADFNY IKSLSSFESG KFVECTEQLE LLPGENINLL AGGSKEKIDM KKLLPNMLSP 1150 1160 1170 1180 1190 1200 DPRELQKSIE VQLLRSSVCL ATALNPIEQD QKWQSITENV VKYLKQTSRI AIGPLRLSTL 1210 1220 1230 1240 1250 1260 TVSQSLPVLS TLQLYCSSAL ENTVSNRLST EDCLIPLFSE ALRSCKQHDV RPWMQALRYT 1270 1280 1290 1300 1310 1320 MYQNQLLEKI KEQTVPIRSH LMELGLTAAK FARKRGNVSL ATRLLAQCSE VQLGKTTTAQ 1330 1340 1350 1360 1370 1380 DLVQHFKKLS TQGQVDEKWG PELDIEKTKL LYTAGQSTHA MEMLSSCAIS FCKSVKAEYA 1390 1400 1410 1420 1430 1440 VAKSILTLAK WIQAEWKEIS GQLKQVYRAQ HQQNFTGLST LSKNILTLIE LPSVNTMEEE 1450 1460 1470 1480 1490 1500 YPRIESESTV HIGVGEPDFI LGQLYHLSSV QAPEVAKSWA ALASWAYRWG RKVVDNASQG 1510 1520 1530 1540 1550 1560 EGVRLLPREK SEVQNLLPDT ITEEEKERIY GILGQAVCRP AGIQDEDITL QITESEDNEE 1570 1580 1590 1600 1610 1620 DDMVDVIWRQ LISSCPWLSE LDESATEGVI KVWRKVVDRI FSLYKLSCSA YFTFLKLNAG 1630 1640 1650 1660 1670 1680 QIPLDEDDPR LHLSHRVEQS TDDMIVMATL RLLRLLVKHA GELRQYLEHG LETTPTAPWR 1690 1700 1710 1720 1730 1740 GIIPQLFSRL NHPEVYVRQS ICNLLCRVAQ DSPHLILYPA IVGTISLSSE SQASGNKFST 1750 1760 1770 1780 1790 1800 AIPTLLGNIQ GEELLVSECE GGSPPASQDS NKDEPKSGLN EDQAMMQDCY SKIVDKLSSA 1810 1820 1830 1840 1850 1860 NPTMVLQVQM LVAELRRVTV LWDELWLGVL LQQHMYVLRR IQQLEDEVKR VQNNNTLRKE 1870 1880 1890 1900 1910 1920 EKIAIMREKH TALMKPIVFA LEHVRSITAA PAETPHEKWF QDNYGDAIEN ALEKLKTPLN 1930 1940 1950 1960 1970 1980 PAKPGSSWIP FKEIMLSLQQ RAQKRASYIL RLEEISPWLA AMTNTEIALP GEVSARDTVT 1990 2000 2010 2020 2030 2040 IHSVGGTITI LPTKTKPKKL LFLGSDGKSY PYLFKGLEDL HLDERIMQFL SIVNTMFATI 2050 2060 2070 2080 2090 2100 NRQETPRFHA RHYSVTPLGT RSGLIQWVDG ATPLFGLYKR WQQREAALQA QKAQDSYQTP 2110 2120 2130 2140 2150 2160 QNPGIVPRPS ELYYSKIGPA LKTVGLSLDV SRRDWPLHVM KAVLEELMEA TPPNLLAKEL 2170 2180 2190 2200 2210 2220 WSSCTTPDEW WRVTQSYARS TAVMSMVGYI IGLGDRHLDN VLIDMTTGEV VHIDYNVCFE 2230 2240 2250 2260 2270 2280 KGKSLRVPEK VPFRMTQNIE TALGVTGVEG VFRLSCEQVL HIMRRGRETL LTLLEAFVYD 2290 2300 2310 2320 2330 2340 PLVDWTAGGE AGFAGAVYGG GGQQAESKQS KREMEREITR SLFSSRVAEI KVNWFKNRDE 2350 2360 2370 2380 2390 2400 MLVVLPKLDG SLDEYLSLQE QLTDVEKLQG KLLEEIEFLE GAEGVDHPSH TLQHRYSEHT 2410 2420 2430 2440 2450 2460 QLQTQQRAVQ EAIQVKLNEF EQWITHYQAA FNNLEATQLA SLLQEISTQM DLGPPSYVPA 2470 2480 2490 2500 2510 2520 TAFLQNAGQA HLISQCEQLE GEVGALLQQR RSVLRGCLEQ LHHYATVALQ YPKAIFQKHR 2530 2540 2550 2560 2570 2580 IEQWKTWMEE LICNTTVERC QELYRKYEMQ YAPQPPPTVC QFITATEMTL QRYAADINSR 2590 2600 2610 2620 2630 2640 LIRQVERLKQ EAVTVPVCED QLKEIERCIK VFLHENGEEG SLSLASVIIS ALCTLTRRNL 2650 2660 2670 2680 2690 2700 MMEGAASSAG EQLVDLTSRD GAWFLEELCS MSGNVTCLVQ LLKQCHLVPQ DLDIPNPMEA 2710 2720 2730 2740 2750 2760 SETVHLANGV YTSLQELNSN FRQIIFPEAL RCLMKGEYTL ESMLHELDGL IEQTTDGVPL 2770 2780 2790 2800 2810 2820 QTLVESLQAY LRNAAMGLEE ETHAHYIDVA RLLHAQYGEL IQPRNGSVDE TPKMSAGQML 2830 2840 2850 2860 2870 2880 LVAFDGMFAQ VETAFSLLVE KLNKMEIPIA WRKIDIIREA RSTQVNFFDD DNHRQVLEEI 2890 2900 2910 2920 2930 2940 FFLKRLQTIK EFFRLCGTFS KTLSGSSSLE DQNTVNGPVQ IVNVKTLFRN SCFSEDQMAK 2950 2960 2970 2980 2990 3000 PIKAFTADFV RQLLIGLPNQ ALGLTLCSFI SALGVDIIAQ VEAKDFGAES KVSVDDLCKK 3010 3020 3030 3040 3050 3060 AVEHNIQIGK FSQLVMNRAT VLASSYDTAW KKHDLVRRLE TSISSCKTSL QRVQLHIAMF 3070 3080 3090 3100 3110 3120 QWQHEDLLIN RPQAMSVTPP PRSAILTSMK KKLHTLSQIE TSIATVQEKL AALESSIEQR 3130 3140 3150 3160 3170 3180 LKWAGGANPA LAPVLQDFEA TIAERRNLVL KESQRASQVT FLCSNIIHFE SLRTRTAEAL 3190 3200 3210 3220 3230 3240 NLDAALFELI KRCQQMCSFA SQFNSSVSEL ELRLLQRVDT GLEHPIGSSE WLLSAHKQLT 3250 3260 3270 3280 3290 3300 QDMSTQRAIQ TEKEQQIETV CETIQNLVDN IKTVLTGHNR QLGDVKHLLK AMAKDEEAAL 3310 3320 3330 3340 3350 3360 ADGEDVPYEN SVRQFLGEYK SWQDNIQTVL FTLVQAMGQV RSQEHVEMLQ EITPTLKELK 3370 3380 3390 3400 3410 3420 TQSQSIYNNL VSFASPLVTD ATNECSSPTS SATYQPSFAA AVRSNTGQKT QPDVMSQNAR 3430 3440 3450 3460 3470 3480 KLIQKNLATS ADTPPSTVPG TGKSVACSPK KAVRDPKTGK AVQERNSYAV SVWKRVKAKL 3490 3500 3510 3520 EGRDVDPNRR MSVAEQVDYV IKEATNLDNL AQLYEGWTAW V
	Isoform 3 [UniParc]. Checksum: 1932F4BF6722348C	FASTA	3,031	340,674
	10 20 30 40 50 60 MWALSPTVFA LLSKNLMIVH SDLAVHFPAI QYAVLYTLYS HCTRHDHFIS SSLSSSSPSL 70 80 90 100 110 120 FDGAVISTVT TATKKHFSII LNLLGILLKK DNLNQDTRKL LMTWALEAAV LMKKSETYAP 130 140 150 160 170 180 LFSLPSFHKF CKGLLANTLV EDVNICLQAC SSLHALSSSL PDDLLQRCVD VCRVQLVHSG 190 200 210 220 230 240 TRIRQAFGKL LKSIPLDVVL SNNNHTEIQE ISLALRSHMS KAPSNTFHPQ DFSDVISFIL 250 260 270 280 290 300 YGNSHRTGKD NWLERLFYSC QRLDKRDQST IPRNLLKTDA VLWQWAIWEA AQFTVLSKLR 310 320 330 340 350 360 TPLGRAQDTF QTIEGIIRSL AAHTLNPDQD VSQWTTADND EGHGNNQLRL VLLLQYLENL 370 380 390 400 410 420 EKLMYNAYEG CANALTSPPK VIRTFFYTNR QTCQDWLTRI RLSIMRVGLL AGQPAVTVRH 430 440 450 460 470 480 GFDLLTEMKT TSLSQGNELE VTIMMVVEAL CELHCPEAIQ GIAVWSSSIV GKNLLWINSV 490 500 510 520 530 540 AQQAEGRFEK ASVEYQEHLC AMTGVDCCIS SFDKSVLTLA NAGRNSASPK HSLNGESRKT 550 560 570 580 590 600 VLSKPTDSSP EVINYLGNKA CECYISIADW AAVQEWQNAI HDLKKSTSST SLNLKADFNY 610 620 630 640 650 660 IKSLSSFESG KFVECTEQLE LLPGENINLL AGGSKEKIDM KKLLPNMLSP DPRELQKSIE 670 680 690 700 710 720 VQLLRSSVCL ATALNPIEQD QKWQSITENV VKYLKQTSRI AIGPLRLSTL TVSQSLPVLS 730 740 750 760 770 780 TLQLYCSSAL ENTVSNRLST EDCLIPLFSE ALRSCKQHDV RPWMQALRYT MYQNQLLEKI 790 800 810 820 830 840 KEQTVPIRSH LMELGLTAAK FARKRGNVSL ATRLLAQCSE VQLGKTTTAQ DLVQHFKKLS 850 860 870 880 890 900 TQGQVDEKWG PELDIEKTKL LYTAGQSTHA MEMLSSCAIS FCKSVKAEYA VAKSILTLAK 910 920 930 940 950 960 WIQAEWKEIS GQLKQVYRAQ HQQNFTGLST LSKNILTLIE LPSVNTMEEE YPRIESESTV 970 980 990 1000 1010 1020 HIGVGEPDFI LGQLYHLSSV QAPEVAKSWA ALASWAYRWG RKVVDNASQG EGVRLLPREK 1030 1040 1050 1060 1070 1080 SEVQNLLPDT ITEEEKERIY GILGQAVCRP AGIQDEDITL QITESEDNEE DDMVDVIWRQ 1090 1100 1110 1120 1130 1140 LISSCPWLSE LDESATEGVI KVWRKVVDRI FSLYKLSCSA YFTFLKLNAG QIPLDEDDPR 1150 1160 1170 1180 1190 1200 LHLSHRVEQS TDDMIVMATL RLLRLLVKHA GELRQYLEHG LETTPTAPWR GIIPQLFSRL 1210 1220 1230 1240 1250 1260 NHPEVYVRQS ICNLLCRVAQ DSPHLILYPA IVGTISLSSE SQASGNKFST AIPTLLGNIQ 1270 1280 1290 1300 1310 1320 GEELLVSECE GGSPPASQDS NKDEPKSGLN EDQAMMQDCY SKIVDKLSSA NPTMVLQVQM 1330 1340 1350 1360 1370 1380 LVAELRRVTV LWDELWLGVL LQQHMYVLRR IQQLEDEVKR VQNNNTLRKE EKIAIMREKH 1390 1400 1410 1420 1430 1440 TALMKPIVFA LEHVRSITAA PAETPHEKWF QDNYGDAIEN ALEKLKTPLN PAKPGSSWIP 1450 1460 1470 1480 1490 1500 FKEIMLSLQQ RAQKRASYIL RLEEISPWLA AMTNTEIALP GEVSARDTVT IHSVGGTITI 1510 1520 1530 1540 1550 1560 LPTKTKPKKL LFLGSDGKSY PYLFKGLEDL HLDERIMQFL SIVNTMFATI NRQETPRFHA 1570 1580 1590 1600 1610 1620 RHYSVTPLGT RSGLIQWVDG ATPLFGLYKR WQQREAALQA QKAQDSYQTP QNPGIVPRPS 1630 1640 1650 1660 1670 1680 ELYYSKIGPA LKTVGLSLDV SRRDWPLHVM KAVLEELMEA TPPNLLAKEL WSSCTTPDEW 1690 1700 1710 1720 1730 1740 WRVTQSYARS TAVMSMVGYI IGLGDRHLDN VLIDMTTGEV VHIDYNVCFE KGKSLRVPEK 1750 1760 1770 1780 1790 1800 VPFRMTQNIE TALGVTGVEG VFRLSCEQVL HIMRRGRETL LTLLEAFVYD PLVDWTAGGE 1810 1820 1830 1840 1850 1860 AGFAGAVYGG GGQQAESKQS KREMEREITR SLFSSRVAEI KVNWFKNRDE MLVVLPKLDG 1870 1880 1890 1900 1910 1920 SLDEYLSLQE QLTDVEKLQG KLLEEIEFLE GAEGVDHPSH TLQHRYSEHT QLQTQQRAVQ 1930 1940 1950 1960 1970 1980 EAIQVKLNEF EQWITHYQAA FNNLEATQLA SLLQEISTQM DLGPPSYVPA TAFLQNAGQA 1990 2000 2010 2020 2030 2040 HLISQCEQLE GEVGALLQQR RSVLRGCLEQ LHHYATVALQ YPKAIFQKHR IEQWKTWMEE 2050 2060 2070 2080 2090 2100 LICNTTVERC QELYRKYEMQ YAPQPPPTVC QFITATEMTL QRYAADINSR LIRQVERLKQ 2110 2120 2130 2140 2150 2160 EAVTVPVCED QLKEIERCIK VFLHENGEEG SLSLASVIIS ALCTLTRRNL MMEGAASSAG 2170 2180 2190 2200 2210 2220 EQLVDLTSRD GAWFLEELCS MSGNVTCLVQ LLKQCHLVPQ DLDIPNPMEA SETVHLANGV 2230 2240 2250 2260 2270 2280 YTSLQELNSN FRQIIFPEAL RCLMKGEYTL ESMLHELDGL IEQTTDGVPL QTLVESLQAY 2290 2300 2310 2320 2330 2340 LRNAAMGLEE ETHAHYIDVA RLLHAQYGEL IQPRNGSVDE TPKMSAGQML LVAFDGMFAQ 2350 2360 2370 2380 2390 2400 VETAFSLLVE KLNKMEIPIA WRKIDIIREA RSTQVNFFDD DNHRQVLEEI FFLKRLQTIK 2410 2420 2430 2440 2450 2460 EFFRLCGTFS KTLSGSSSLE DQNTVNGPVQ IVNVKTLFRN SCFSEDQMAK PIKAFTADFV 2470 2480 2490 2500 2510 2520 RQLLIGLPNQ ALGLTLCSFI SALGVDIIAQ VEAKDFGAES KVSVDDLCKK AVEHNIQIGK 2530 2540 2550 2560 2570 2580 FSQLVMNRAT VLASSYDTAW KKHDLVRRLE TSISSCKTSL QRVQLHIAMF QWQHEDLLIN 2590 2600 2610 2620 2630 2640 RPQAMSVTPP PRSAILTSMK KKLHTLSQIE TSIATVQEKL AALESSIEQR LKWAGGANPA 2650 2660 2670 2680 2690 2700 LAPVLQDFEA TIAERRNLVL KESQRASQVT FLCSNIIHFE SLRTRTAEAL NLDAALFELI 2710 2720 2730 2740 2750 2760 KRCQQMCSFA SQFNSSVSEL ELRLLQRVDT GLEHPIGSSE WLLSAHKQLT QDMSTQRAIQ 2770 2780 2790 2800 2810 2820 TEKEQQIETV CETIQNLVDN IKTVLTGHNR QLGDVKHLLK AMAKDEEAAL ADGEDVPYEN 2830 2840 2850 2860 2870 2880 SVRQFLGEYK SWQDNIQTVL FTLVQAMGQV RSQEHVEMLQ EITPTLKELK TQSQSIYNNL 2890 2900 2910 2920 2930 2940 VSFASPLVTD ATNECSSPTS SATYQPSFAA AVRSNTGQKT QPDVMSQNAR KLIQKNLATS 2950 2960 2970 2980 2990 3000 ADTPPSTVPG TGKSVACSPK KAVRDPKTGK AVQERNSYAV SVWKRVKAKL EGRDVDPNRR 3010 3020 3030 MSVAEQVDYV IKEATNLDNL AQLYEGWTAW V
	Isoform 4 (BLIP) [UniParc]. Checksum: D63ECA30F812D7A6	FASTA	2,392	269,425
	10 20 30 40 50 60 MKKLLPNMLS PDPRELQKSI EVQLLRSSVC LATALNPIEQ DQKWQSITEN VVKYLKQTSR 70 80 90 100 110 120 IAIGPLRLST LTVSQSLPVL STLQLYCSSA LENTVSNRLS TEDCLIPLFS EALRSCKQHD 130 140 150 160 170 180 VRPWMQALRY TMYQNQLLEK IKEQTVPIRS HLMELGLTAA KFARKRGNVS LATRLLAQCS 190 200 210 220 230 240 EVQLGKTTTA QDLVQHFKKL STQGQVDEKW GPELDIEKTK LLYTAGQSTH AMEMLSSCAI 250 260 270 280 290 300 SFCKSVKAEY AVAKSILTLA KWIQAEWKEI SGQLKQVYRA QHQQNFTGLS TLSKNILTLI 310 320 330 340 350 360 ELPSVNTMEE EYPRIESEST VHIGVGEPDF ILGQLYHLSS VQAPEVAKSW AALASWAYRW 370 380 390 400 410 420 GRKVVDNASQ GEGVRLLPRE KSEVQNLLPD TITEEEKERI YGILGQAVCR PAGIQDEDIT 430 440 450 460 470 480 LQITESEDNE EDDMVDVIWR QLISSCPWLS ELDESATEGV IKVWRKVVDR IFSLYKLSCS 490 500 510 520 530 540 AYFTFLKLNA GQIPLDEDDP RLHLSHRVEQ STDDMIVMAT LRLLRLLVKH AGELRQYLEH 550 560 570 580 590 600 GLETTPTAPW RGIIPQLFSR LNHPEVYVRQ SICNLLCRVA QDSPHLILYP AIVGTISLSS 610 620 630 640 650 660 ESQASGNKFS TAIPTLLGNI QGEELLVSEC EGGSPPASQD SNKDEPKSGL NEDQAMMQDC 670 680 690 700 710 720 YSKIVDKLSS ANPTMVLQVQ MLVAELRRVT VLWDELWLGV LLQQHMYVLR RIQQLEDEVK 730 740 750 760 770 780 RVQNNNTLRK EEKIAIMREK HTALMKPIVF ALEHVRSITA APAETPHEKW FQDNYGDAIE 790 800 810 820 830 840 NALEKLKTPL NPAKPGSSWI PFKEIMLSLQ QRAQKRASYI LRLEEISPWL AAMTNTEIAL 850 860 870 880 890 900 PGEVSARDTV TIHSVGGTIT ILPTKTKPKK LLFLGSDGKS YPYLFKGLED LHLDERIMQF 910 920 930 940 950 960 LSIVNTMFAT INRQETPRFH ARHYSVTPLG TRSGLIQWVD GATPLFGLYK RWQQREAALQ 970 980 990 1000 1010 1020 AQKAQDSYQT PQNPGIVPRP SELYYSKIGP ALKTVGLSLD VSRRDWPLHV MKAVLEELME 1030 1040 1050 1060 1070 1080 ATPPNLLAKE LWSSCTTPDE WWRVTQSYAR STAVMSMVGY IIGLGDRHLD NVLIDMTTGE 1090 1100 1110 1120 1130 1140 VVHIDYNVCF EKGKSLRVPE KVPFRMTQNI ETALGVTGVE GVFRLSCEQV LHIMRRGRET 1150 1160 1170 1180 1190 1200 LLTLLEAFVY DPLVDWTAGG EAGFAGAVYG GGGQQAESKQ SKREMEREIT RSLFSSRVAE 1210 1220 1230 1240 1250 1260 IKVNWFKNRD EMLVVLPKLD GSLDEYLSLQ EQLTDVEKLQ GKLLEEIEFL EGAEGVDHPS 1270 1280 1290 1300 1310 1320 HTLQHRYSEH TQLQTQQRAV QEAIQVKLNE FEQWITHYQA AFNNLEATQL ASLLQEISTQ 1330 1340 1350 1360 1370 1380 MDLGPPSYVP ATAFLQNAGQ AHLISQCEQL EGEVGALLQQ RRSVLRGCLE QLHHYATVAL 1390 1400 1410 1420 1430 1440 QYPKAIFQKH RIEQWKTWME ELICNTTVER CQELYRKYEM QYAPQPPPTV CQFITATEMT 1450 1460 1470 1480 1490 1500 LQRYAADINS RLIRQVERLK QEAVTVPVCE DQLKEIERCI KVFLHENGEE GSLSLASVII 1510 1520 1530 1540 1550 1560 SALCTLTRRN LMMEGAASSA GEQLVDLTSR DGAWFLEELC SMSGNVTCLV QLLKQCHLVP 1570 1580 1590 1600 1610 1620 QDLDIPNPME ASETVHLANG VYTSLQELNS NFRQIIFPEA LRCLMKGEYT LESMLHELDG 1630 1640 1650 1660 1670 1680 LIEQTTDGVP LQTLVESLQA YLRNAAMGLE EETHAHYIDV ARLLHAQYGE LIQPRNGSVD 1690 1700 1710 1720 1730 1740 ETPKMSAGQM LLVAFDGMFA QVETAFSLLV EKLNKMEIPI AWRKIDIIRE ARSTQVNFFD 1750 1760 1770 1780 1790 1800 DDNHRQVLEE IFFLKRLQTI KEFFRLCGTF SKTLSGSSSL EDQNTVNGPV QIVNVKTLFR 1810 1820 1830 1840 1850 1860 NSCFSEDQMA KPIKAFTADF VRQLLIGLPN QALGLTLCSF ISALGVDIIA QVEAKDFGAE 1870 1880 1890 1900 1910 1920 SKVSVDDLCK KAVEHNIQIG KFSQLVMNRA TVLASSYDTA WKKHDLVRRL ETSISSCKTS 1930 1940 1950 1960 1970 1980 LQRVQLHIAM FQWQHEDLLI NRPQAMSVTP PPRSAILTSM KKKLHTLSQI ETSIATVQEK 1990 2000 2010 2020 2030 2040 LAALESSIEQ RLKWAGGANP ALAPVLQDFE ATIAERRNLV LKESQRASQV TFLCSNIIHF 2050 2060 2070 2080 2090 2100 ESLRTRTAEA LNLDAALFEL IKRCQQMCSF ASQFNSSVSE LELRLLQRVD TGLEHPIGSS 2110 2120 2130 2140 2150 2160 EWLLSAHKQL TQDMSTQRAI QTEKEQQIET VCETIQNLVD NIKTVLTGHN RQLGDVKHLL 2170 2180 2190 2200 2210 2220 KAMAKDEEAA LADGEDVPYE NSVRQFLGEY KSWQDNIQTV LFTLVQAMGQ VRSQEHVEML 2230 2240 2250 2260 2270 2280 QEITPTLKEL KTQSQSIYNN LVSFASPLVT DATNECSSPT SSATYQPSFA AAVRSNTGQK 2290 2300 2310 2320 2330 2340 TQPDVMSQNA RKLIQKNLAT SADTPPSTVP GTGKSVACSP KKAVRDPKTG KAVQERNSYA 2350 2360 2370 2380 2390 VSVWKRVKAK LEGRDVDPNR RMSVAEQVDY VIKEATNLDN LAQLYEGWTA WV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Localization of atypical protein kinase C isoforms into lysosome-targeted endosomes through interaction with p62." Sanchez P., De Carcer G., Sandoval I.V., Moscat J., Diaz-Meco M.T. Mol. Cell. Biol. 18:3069-3080(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
[2]	"Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay." Yamashita A., Ohnishi T., Kashima I., Taya Y., Ohno S. Genes Dev. 15:2215-2228(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, PHOSPHORYLATION OF RENT1, ALTERNATIVE SPLICING, ENZYME REGULATION, PHOSPHORYLATION, INTERACTION WITH RENT1; UPF2 AND UPF3, MUTAGENESIS OF ASP-2335.
[3]	"Cloning of a novel phosphatidylinositol kinase-related kinase: characterization of the human SMG-1 RNA surveillance protein." Denning G., Jamieson L., Maquat L.E., Thompson E.A., Fields A.P. J. Biol. Chem. 276:22709-22714(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), FUNCTION, PHOSPHORYLATION OF RENT1, COFACTOR, ENZYME REGULATION, MUTAGENESIS OF ASP-2335.
[4]	"The mRNA surveillance protein hSMG-1 functions in genotoxic stress response pathways in mammalian cells." Brumbaugh K.M., Otterness D.M., Geisen C., Oliveira V., Brognard J., Li X., Lejeune F., Tibbetts R.S., Maquat L.E., Abraham R.T. Mol. Cell 14:585-598(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, PHOSPHORYLATION OF TP53, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, ENZYME REGULATION, MUTAGENESIS OF ASP-2335, VARIANTS CYS-144 AND LYS-612.
[5]	"The sequence and analysis of duplication-rich human chromosome 16." Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A. Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro." Ishikawa K., Nagase T., Nakajima D., Seki N., Ohira M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 4:307-313(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1674-3661. Tissue: Brain.
[7]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION.
[8]	"Lambda-interacting protein, a novel protein that specifically interacts with the zinc finger domain of the atypical protein kinase C isotype lambda/iota and stimulates its kinase activity in vitro and in vivo." Diaz-Meco M.T., Municio M.M., Sanchez P., Lozano J., Moscat J. Mol. Cell. Biol. 16:105-114(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2878-3661, TISSUE SPECIFICITY, INTERACTION WITH PRKCI.
[9]	"Divergent origins and concerted expansion of two segmental duplications on chromosome 16." Eichler E.E., Johnson M.E., Alkan C., Tuzun E., Sahinalp C., Misceo D., Archidiacono N., Rocchi M. J. Hered. 92:462-468(2001) [PubMed] [Europe PMC] [Abstract] Cited for: DUPLICATION.
[10]	"Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7." Ohnishi T., Yamashita A., Kashima I., Schell T., Anders K.R., Grimson A., Hachiya T., Hentze M.W., Anderson P., Ohno S. Mol. Cell 12:1187-1200(2003) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH SMG5.
[11]	"Characterization of human Smg5/7a: a protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1." Chiu S.-Y., Serin G., Ohara O., Maquat L.E. RNA 9:77-87(2003) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH RENT1; UPF2; EST1A AND UPF3B.
[12]	"Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay." Kashima I., Yamashita A., Izumi N., Kataoka N., Morishita R., Hoshino S., Ohno M., Dreyfuss G., Ohno S. Genes Dev. 20:355-367(2006) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH UPF2, IDENTIFICATION IN THE SURF COMPLEX.
[13]	"A probability-based approach for high-throughput protein phosphorylation analysis and site localization." Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[14]	"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-3550 AND SER-3556, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[15]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3570, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[16]	"SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay." Yamashita A., Izumi N., Kashima I., Ohnishi T., Saari B., Katsuhata Y., Muramatsu R., Morita T., Iwamatsu A., Hachiya T., Kurata R., Hirano H., Anderson P., Ohno S. Genes Dev. 23:1091-1105(2009) [PubMed] [Europe PMC] [Abstract] Cited for: CATALYTIC ACTIVITY, IDENTIFICATION IN THE SMG1C COMPLEX.
[17]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Leukemic T-cell.
[18]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-173, MASS SPECTROMETRY.
[19]	"Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly." Kaizuka T., Hara T., Oshiro N., Kikkawa U., Yonezawa K., Takehana K., Iemura S., Natsume T., Mizushima N. J. Biol. Chem. 285:20109-20116(2010) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH TELO2 AND TTI1.
[20]	"A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability." Hurov K.E., Cotta-Ramusino C., Elledge S.J. Genes Dev. 24:1939-1950(2010) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH TTI1.
[21]	"AAA+ proteins RUVBL1 and RUVBL2 coordinate PIKK activity and function in nonsense-mediated mRNA decay." Izumi N., Yamashita A., Iwamatsu A., Kurata R., Nakamura H., Saari B., Hirano H., Anderson P., Ohno S. Sci. Signal. 3:RA27-RA27(2010) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH RUVBL1 AND RUVBL2.
[22]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-3573, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[23]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[24]	"The nonsense-mediated mRNA decay SMG-1 kinase is regulated by large-scale conformational changes controlled by SMG-8." Arias-Palomo E., Yamashita A., Fernandez I.S., Nunez-Ramirez R., Bamba Y., Izumi N., Ohno S., Llorca O. Genes Dev. 25:153-164(2011) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH SMG8 AND SMG9, ELECTRON MICROSCOPY OF THE SMG1C COMPLEX.
[25]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[26]	"Patterns of somatic mutation in human cancer genomes." Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R. Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] THR-35; CYS-126; CYS-144; TYR-151; ASN-160; VAL-167; GLY-320; SER-465; ARG-546; SER-588; LYS-612; CYS-753; CYS-809; CYS-812; ILE-829; ASP-832; GLY-952; SER-969; LEU-1016; GLN-1029; SER-1072; HIS-1103; ARG-1275; PRO-1292; VAL-1332; PRO-1358; THR-1418; CYS-2171; SER-2258; LYS-2345; GLU-2730; SER-2889; ALA-2899; THR-3239 AND GLN-3583.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF186377 mRNA. Translation: AAK58892.1. AB061371 mRNA. Translation: BAB70696.1. AY014957 mRNA. Translation: AAK00511.1. AF395444 mRNA. Translation: AAM73708.1. AC092287 Genomic DNA. No translation available. AB007881 mRNA. Translation: BAA24851.2. U32581 mRNA. Translation: AAA86535.2. Different initiation.
IPI	IPI00183368. IPI00639874. IPI00640955. IPI00939320.
PIR	JC6084.
RefSeq	NP_055907.3. NM_015092.4.
UniGene	Hs.460179.
3D structure databases
ProteinModelPortal	Q96Q15.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96Q15. 30 interactions.
MINT	MINT-1513197.
STRING	9606.ENSP00000402515.
PTM databases
PhosphoSite	Q96Q15.
Polymorphism databases
DMDM	91208166.
Proteomic databases
PaxDb	Q96Q15.
PRIDE	Q96Q15.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000446231; ENSP00000402515; ENSG00000157106.
GeneID	23049.
KEGG	hsa:23049.
UCSC	uc002dfm.3. human.
Organism-specific databases
CTD	23049.
GeneCards	GC16M018816.
H-InvDB	HIX0012849. HIX0038625. HIX0202313.
HGNC	HGNC:30045. SMG1.
HPA	HPA006870.
MIM	607032. gene.
neXtProt	NX_Q96Q15.
PharmGKB	PA164725852.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5032.
HOGENOM	HOG000168703.
HOVERGEN	HBG093965.
InParanoid	Q96Q15.
KO	K08873.
OrthoDB	EOG4320X5.
Enzyme and pathway databases
Reactome	REACT_21257. Metabolism of RNA. REACT_71. Gene Expression.
Gene expression databases
ArrayExpress	Q96Q15.
Bgee	Q96Q15.
Genevestigator	Q96Q15.
GermOnline	ENSG00000157106. Homo sapiens.
Family and domain databases
Gene3D	1.10.1070.11. 2 hits.
InterPro	IPR016024. ARM-type_fold. IPR003152. FATC. IPR011009. Kinase-like_dom. IPR000403. PI3/4_kinase_cat_dom. IPR018936. PI3/4_kinase_CS. IPR014009. PIK_FAT. [Graphical view]
Pfam	PF02260. FATC. 1 hit. PF00454. PI3_PI4_kinase. 1 hit. [Graphical view]
SMART	SM00146. PI3Kc. 1 hit. [Graphical view]
SUPFAM	SSF48371. ARM-type_fold. 1 hit. SSF56112. Kinase_like. 1 hit.
PROSITE	PS51189. FAT. 1 hit. PS51190. FATC. 1 hit. PS50077. HEAT_REPEAT. False negative. PS00915. PI3_4_KINASE_1. False negative. PS00916. PI3_4_KINASE_2. 1 hit. PS50290. PI3_4_KINASE_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChEMBL	CHEMBL1795195.
ChiTaRS	SMG1. human.
GenomeRNAi	23049.
NextBio	44092.
SOURCE	Search...

Entry information

Entry name

SMG1_HUMAN

Accession

Primary (citable) accession number: Q96Q15
Secondary accession number(s): O43305 , Q13284, Q8NFX2, Q96QV0, Q96RW3

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	February 8, 2011
Last modified:	April 3, 2013
This is version 101 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.