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Protein

Perilipin-4

Gene

PLIN4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in triacylglycerol packaging into adipocytes. May function as a coat protein involved in the biogenesis of lipid droplets (By similarity).By similarity

Enzyme and pathway databases

BioCyciZFISH:ENSG00000167676-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Perilipin-4
Alternative name(s):
Adipocyte protein S3-12
Gene namesi
Name:PLIN4
Synonyms:KIAA1881
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:29393. PLIN4.

Subcellular locationi

  • Cell membrane By similarity
  • Cytoplasm By similarity
  • Lipid droplet By similarity

  • Note: Nascent lipid droplet surface-associated; association with lipid droplets is triacylglycerol synthesis-dependent.By similarity

GO - Cellular componenti

  • cytoplasm Source: HPA
  • intracellular membrane-bounded organelle Source: HPA
  • lipid particle Source: UniProtKB
  • plasma membrane Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Lipid droplet, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi729359.
OpenTargetsiENSG00000167676.
PharmGKBiPA165394042.

Polymorphism and mutation databases

BioMutaiPLIN4.
DMDMi156630940.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002975591 – 1357Perilipin-4Add BLAST1357

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10PhosphoserineBy similarity1
Modified residuei16PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96Q06.
MaxQBiQ96Q06.
PaxDbiQ96Q06.
PeptideAtlasiQ96Q06.
PRIDEiQ96Q06.

PTM databases

iPTMnetiQ96Q06.
PhosphoSitePlusiQ96Q06.

Expressioni

Inductioni

Up-regulated during adipocyte differentiation.1 Publication

Gene expression databases

BgeeiENSG00000167676.
CleanExiHS_KIAA1881.
ExpressionAtlasiQ96Q06. baseline and differential.
GenevisibleiQ96Q06. HS.

Organism-specific databases

HPAiHPA044682.
HPA054657.

Interactioni

Protein-protein interaction databases

BioGridi609760. 4 interactors.
IntActiQ96Q06. 2 interactors.
STRINGi9606.ENSP00000301286.

Structurei

3D structure databases

ProteinModelPortaliQ96Q06.
SMRiQ96Q06.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati95 – 1271Add BLAST33
Repeati128 – 1602Add BLAST33
Repeati161 – 1933Add BLAST33
Repeati194 – 2264Add BLAST33
Repeati227 – 2595Add BLAST33
Repeati260 – 2926Add BLAST33
Repeati293 – 3257Add BLAST33
Repeati326 – 3588Add BLAST33
Repeati359 – 3919Add BLAST33
Repeati392 – 42410Add BLAST33
Repeati425 – 45711Add BLAST33
Repeati458 – 49012Add BLAST33
Repeati491 – 52313Add BLAST33
Repeati524 – 55614Add BLAST33
Repeati557 – 58915Add BLAST33
Repeati590 – 62216Add BLAST33
Repeati623 – 65517Add BLAST33
Repeati656 – 68818Add BLAST33
Repeati689 – 72119Add BLAST33
Repeati722 – 75420Add BLAST33
Repeati755 – 78721Add BLAST33
Repeati788 – 82022Add BLAST33
Repeati821 – 85323Add BLAST33
Repeati854 – 88624Add BLAST33
Repeati887 – 91925Add BLAST33
Repeati920 – 95226Add BLAST33
Repeati953 – 98527Add BLAST33

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni95 – 98527 X 33 AA approximate tandem repeatAdd BLAST891

Sequence similaritiesi

Belongs to the perilipin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IHSW. Eukaryota.
ENOG4112C4W. LUCA.
GeneTreeiENSGT00500000044795.
HOGENOMiHOG000113183.
HOVERGENiHBG099259.
InParanoidiQ96Q06.
KOiK20254.
OMAiQCGLDTS.
OrthoDBiEOG091G017D.
PhylomeDBiQ96Q06.
TreeFamiTF328397.

Family and domain databases

InterProiIPR004279. Perilipin.
[Graphical view]
PANTHERiPTHR14024. PTHR14024. 3 hits.
PfamiPF03036. Perilipin. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96Q06-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQTLGSFFGS LPGFSSARNL VANAHSSARA RPAADPTGAP AAEAAQPQAQ
60 70 80 90 100
VAAHPEQTAP WTEKELQPSE KQMVSGAKDL VCSKMSRAKD AVSSGVASVV
110 120 130 140 150
DVAKGVVQGG LDTTRSALTG TKEVVSSGVT GAMDMAKGAV QGGLDTSKAV
160 170 180 190 200
LTGTKDTVST GLTGAVNVAK GTVQAGVDTT KTVLTGTKDT VTTGVMGAVN
210 220 230 240 250
LAKGTVQTGV ETSKAVLTGT KDAVSTGLTG AVNVARGSIQ TGVDTSKTVL
260 270 280 290 300
TGTKDTVCSG VTGAMNVAKG TIQTGVDTSK TVLTGTKDTV CSGVTGAMNV
310 320 330 340 350
AKGTIQTGVD TSKTVLTGTK DTVCSGVTGA MNVAKGTIQT GVDTTKTVLT
360 370 380 390 400
GTKNTVCSGV TGAVNLAKEA IQGGLDTTKS MVMGTKDTMS TGLTGAANVA
410 420 430 440 450
KGAMQTGLNT TQNIATGTKD TVCSGVTGAM NLARGTIQTG VDTTKIVLTG
460 470 480 490 500
TKDTVCSGVT GAANVAKGAV QGGLDTTKSV LTGTKDAVST GLTGAVNVAK
510 520 530 540 550
GTVQTGVDTT KTVLTGTKDT VCSGVTSAVN VAKGAVQGGL DTTKSVVIGT
560 570 580 590 600
KDTMSTGLTG AANVAKGAVQ TGVDTAKTVL TGTKDTVTTG LVGAVNVAKG
610 620 630 640 650
TVQTGMDTTK TVLTGTKDTI YSGVTSAVNV AKGAVQTGLK TTQNIATGTK
660 670 680 690 700
NTFGSGVTSA VNVAKGAAQT GVDTAKTVLT GTKDTVTTGL MGAVNVAKGT
710 720 730 740 750
VQTSVDTTKT VLTGTKDTVC SGVTGAANVA KGAIQGGLDT TKSVLTGTKD
760 770 780 790 800
AVSTGLTGAV KLAKGTVQTG MDTTKTVLTG TKDAVCSGVT GAANVAKGAV
810 820 830 840 850
QMGVDTAKTV LTGTKDTVCS GVTGAANVAK GAVQTGLKTT QNIATGTKNT
860 870 880 890 900
LGSGVTGAAK VAKGAVQGGL DTTKSVLTGT KDAVSTGLTG AVNLAKGTVQ
910 920 930 940 950
TGVDTSKTVL TGTKDTVCSG VTGAVNVAKG TVQTGVDTAK TVLSGAKDAV
960 970 980 990 1000
TTGVTGAVNV AKGTVQTGVD ASKAVLMGTK DTVFSGVTGA MSMAKGAVQG
1010 1020 1030 1040 1050
GLDTTKTVLT GTKDAVSAGL MGSGNVATGA THTGLSTFQN WLPSTPATSW
1060 1070 1080 1090 1100
GGLTSSRTTD NGGEQTALSP QEAPFSGIST PPDVLSVGPE PAWEAAATTK
1110 1120 1130 1140 1150
GLATDVATFT QGAAPGREDT GLLATTHGPE EAPRLAMLQN ELEGLGDIFH
1160 1170 1180 1190 1200
PMNAEEQAQL AASQPGPKVL SAEQGSYFVR LGDLGPSFRQ RAFEHAVSHL
1210 1220 1230 1240 1250
QHGQFQARDT LAQLQDCFRL IEKAQQAPEG QPRLDQGSGA SAEDAAVQEE
1260 1270 1280 1290 1300
RDAGVLSRVC GLLRQLHTAY SGLVSSLQGL PAELQQPVGR ARHSLCELYG
1310 1320 1330 1340 1350
IVASAGSVEE LPAERLVQSR EGVHQAWQGL EQLLEGLQHN PPLSWLVGPF

ALPAGGQ
Length:1,357
Mass (Da):134,431
Last modified:August 21, 2007 - v2
Checksum:i24CCB9D3DD6B480D
GO
Isoform 2 (identifier: Q96Q06-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     720-720: C → CSGVTGAANVAKGAVQTGVDTAKTVLTGTKDTVCSGVTGAVNVAKGAVQTGLKTTQNIATGTKNTLG

Note: No experimental confirmation available.
Show »
Length:1,423
Mass (Da):140,675
Checksum:i15CBE032145C63E0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti263G → S in BAB67774 (PubMed:11572484).Curated1
Sequence conflicti668A → V in BAB67774 (PubMed:11572484).Curated1
Sequence conflicti734I → V in BAB67774 (PubMed:11572484).Curated1
Sequence conflicti819 – 826CSGVTGAA → TTGLMGAV in BAB67774 (PubMed:11572484).Curated8
Sequence conflicti832A → T in BAB67774 (PubMed:11572484).Curated1
Sequence conflicti836 – 844GLKTTQNIA → SVDTTKTVL in BAB67774 (PubMed:11572484).Curated9
Sequence conflicti849 – 852NTLG → DTVC in BAB67774 (PubMed:11572484).Curated4
Sequence conflicti883A → T in BAB67774 (PubMed:11572484).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061507124V → A.1 PublicationCorresponds to variant rs4807597dbSNPEnsembl.1
Natural variantiVAR_061508421T → A.Corresponds to variant rs55901236dbSNPEnsembl.1
Natural variantiVAR_050483659S → G.1 PublicationCorresponds to variant rs7260518dbSNPEnsembl.1
Natural variantiVAR_061509761K → N.1 PublicationCorresponds to variant rs7256387dbSNPEnsembl.1
Natural variantiVAR_061510802M → T.Corresponds to variant rs7256712dbSNPEnsembl.1
Natural variantiVAR_061511826A → E.Corresponds to variant rs7255187dbSNPEnsembl.1
Natural variantiVAR_061512826A → G.Corresponds to variant rs7255187dbSNPEnsembl.1
Natural variantiVAR_061513826A → V.Corresponds to variant rs7255187dbSNPEnsembl.1
Natural variantiVAR_061514860K → N.1 PublicationCorresponds to variant rs7259721dbSNPEnsembl.1
Natural variantiVAR_0346371124A → T.1 PublicationCorresponds to variant rs7251858dbSNPEnsembl.1
Natural variantiVAR_0504841134R → C.Corresponds to variant rs7250947dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_027278720C → CSGVTGAANVAKGAVQTGVD TAKTVLTGTKDTVCSGVTGA VNVAKGAVQTGLKTTQNIAT GTKNTLG in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011498 Genomic DNA. No translation available.
AB067468 mRNA. Translation: BAB67774.1.
CCDSiCCDS45927.1. [Q96Q06-1]
RefSeqiNP_001073869.1. NM_001080400.1. [Q96Q06-1]
UniGeneiHs.591387.

Genome annotation databases

EnsembliENST00000301286; ENSP00000301286; ENSG00000167676. [Q96Q06-1]
GeneIDi729359.
KEGGihsa:729359.
UCSCiuc002mar.2. human. [Q96Q06-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011498 Genomic DNA. No translation available.
AB067468 mRNA. Translation: BAB67774.1.
CCDSiCCDS45927.1. [Q96Q06-1]
RefSeqiNP_001073869.1. NM_001080400.1. [Q96Q06-1]
UniGeneiHs.591387.

3D structure databases

ProteinModelPortaliQ96Q06.
SMRiQ96Q06.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi609760. 4 interactors.
IntActiQ96Q06. 2 interactors.
STRINGi9606.ENSP00000301286.

PTM databases

iPTMnetiQ96Q06.
PhosphoSitePlusiQ96Q06.

Polymorphism and mutation databases

BioMutaiPLIN4.
DMDMi156630940.

Proteomic databases

EPDiQ96Q06.
MaxQBiQ96Q06.
PaxDbiQ96Q06.
PeptideAtlasiQ96Q06.
PRIDEiQ96Q06.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301286; ENSP00000301286; ENSG00000167676. [Q96Q06-1]
GeneIDi729359.
KEGGihsa:729359.
UCSCiuc002mar.2. human. [Q96Q06-1]

Organism-specific databases

CTDi729359.
DisGeNETi729359.
GeneCardsiPLIN4.
H-InvDBHIX0202699.
HGNCiHGNC:29393. PLIN4.
HPAiHPA044682.
HPA054657.
MIMi613247. gene.
neXtProtiNX_Q96Q06.
OpenTargetsiENSG00000167676.
PharmGKBiPA165394042.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHSW. Eukaryota.
ENOG4112C4W. LUCA.
GeneTreeiENSGT00500000044795.
HOGENOMiHOG000113183.
HOVERGENiHBG099259.
InParanoidiQ96Q06.
KOiK20254.
OMAiQCGLDTS.
OrthoDBiEOG091G017D.
PhylomeDBiQ96Q06.
TreeFamiTF328397.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000167676-MONOMER.

Miscellaneous databases

GenomeRNAii729359.
PROiQ96Q06.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000167676.
CleanExiHS_KIAA1881.
ExpressionAtlasiQ96Q06. baseline and differential.
GenevisibleiQ96Q06. HS.

Family and domain databases

InterProiIPR004279. Perilipin.
[Graphical view]
PANTHERiPTHR14024. PTHR14024. 3 hits.
PfamiPF03036. Perilipin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPLIN4_HUMAN
AccessioniPrimary (citable) accession number: Q96Q06
Secondary accession number(s): A6NEI2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: August 21, 2007
Last modified: November 2, 2016
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.