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Protein

Perilipin-4

Gene

PLIN4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in triacylglycerol packaging into adipocytes. May function as a coat protein involved in the biogenesis of lipid droplets (By similarity).By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Perilipin-4
Alternative name(s):
Adipocyte protein S3-12
Gene namesi
Name:PLIN4
Synonyms:KIAA1881
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:29393. PLIN4.

Subcellular locationi

  • Cell membrane By similarity
  • Cytoplasm By similarity
  • Lipid droplet By similarity

  • Note: Nascent lipid droplet surface-associated; association with lipid droplets is triacylglycerol synthesis-dependent.By similarity

GO - Cellular componenti

  • cytoplasm Source: HPA
  • intracellular membrane-bounded organelle Source: HPA
  • lipid particle Source: UniProtKB
  • plasma membrane Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Lipid droplet, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165394042.

Polymorphism and mutation databases

BioMutaiPLIN4.
DMDMi156630940.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13571357Perilipin-4PRO_0000297559Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei10 – 101PhosphoserineBy similarity
Modified residuei16 – 161PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96Q06.
MaxQBiQ96Q06.
PaxDbiQ96Q06.
PeptideAtlasiQ96Q06.
PRIDEiQ96Q06.

PTM databases

iPTMnetiQ96Q06.
PhosphoSiteiQ96Q06.

Expressioni

Inductioni

Up-regulated during adipocyte differentiation.1 Publication

Gene expression databases

BgeeiENSG00000167676.
CleanExiHS_KIAA1881.
ExpressionAtlasiQ96Q06. baseline and differential.
GenevisibleiQ96Q06. HS.

Organism-specific databases

HPAiHPA044682.
HPA054657.

Interactioni

Protein-protein interaction databases

BioGridi609760. 4 interactions.
IntActiQ96Q06. 2 interactions.
STRINGi9606.ENSP00000301286.

Structurei

3D structure databases

ProteinModelPortaliQ96Q06.
SMRiQ96Q06. Positions 1151-1351.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati95 – 127331Add
BLAST
Repeati128 – 160332Add
BLAST
Repeati161 – 193333Add
BLAST
Repeati194 – 226334Add
BLAST
Repeati227 – 259335Add
BLAST
Repeati260 – 292336Add
BLAST
Repeati293 – 325337Add
BLAST
Repeati326 – 358338Add
BLAST
Repeati359 – 391339Add
BLAST
Repeati392 – 4243310Add
BLAST
Repeati425 – 4573311Add
BLAST
Repeati458 – 4903312Add
BLAST
Repeati491 – 5233313Add
BLAST
Repeati524 – 5563314Add
BLAST
Repeati557 – 5893315Add
BLAST
Repeati590 – 6223316Add
BLAST
Repeati623 – 6553317Add
BLAST
Repeati656 – 6883318Add
BLAST
Repeati689 – 7213319Add
BLAST
Repeati722 – 7543320Add
BLAST
Repeati755 – 7873321Add
BLAST
Repeati788 – 8203322Add
BLAST
Repeati821 – 8533323Add
BLAST
Repeati854 – 8863324Add
BLAST
Repeati887 – 9193325Add
BLAST
Repeati920 – 9523326Add
BLAST
Repeati953 – 9853327Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni95 – 98589127 X 33 AA approximate tandem repeatAdd
BLAST

Sequence similaritiesi

Belongs to the perilipin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IHSW. Eukaryota.
ENOG4112C4W. LUCA.
GeneTreeiENSGT00500000044795.
HOGENOMiHOG000113183.
HOVERGENiHBG099259.
InParanoidiQ96Q06.
KOiK20254.
OMAiQCGLDTS.
OrthoDBiEOG091G017D.
PhylomeDBiQ96Q06.
TreeFamiTF328397.

Family and domain databases

InterProiIPR004279. Perilipin.
[Graphical view]
PANTHERiPTHR14024. PTHR14024. 3 hits.
PfamiPF03036. Perilipin. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96Q06-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQTLGSFFGS LPGFSSARNL VANAHSSARA RPAADPTGAP AAEAAQPQAQ
60 70 80 90 100
VAAHPEQTAP WTEKELQPSE KQMVSGAKDL VCSKMSRAKD AVSSGVASVV
110 120 130 140 150
DVAKGVVQGG LDTTRSALTG TKEVVSSGVT GAMDMAKGAV QGGLDTSKAV
160 170 180 190 200
LTGTKDTVST GLTGAVNVAK GTVQAGVDTT KTVLTGTKDT VTTGVMGAVN
210 220 230 240 250
LAKGTVQTGV ETSKAVLTGT KDAVSTGLTG AVNVARGSIQ TGVDTSKTVL
260 270 280 290 300
TGTKDTVCSG VTGAMNVAKG TIQTGVDTSK TVLTGTKDTV CSGVTGAMNV
310 320 330 340 350
AKGTIQTGVD TSKTVLTGTK DTVCSGVTGA MNVAKGTIQT GVDTTKTVLT
360 370 380 390 400
GTKNTVCSGV TGAVNLAKEA IQGGLDTTKS MVMGTKDTMS TGLTGAANVA
410 420 430 440 450
KGAMQTGLNT TQNIATGTKD TVCSGVTGAM NLARGTIQTG VDTTKIVLTG
460 470 480 490 500
TKDTVCSGVT GAANVAKGAV QGGLDTTKSV LTGTKDAVST GLTGAVNVAK
510 520 530 540 550
GTVQTGVDTT KTVLTGTKDT VCSGVTSAVN VAKGAVQGGL DTTKSVVIGT
560 570 580 590 600
KDTMSTGLTG AANVAKGAVQ TGVDTAKTVL TGTKDTVTTG LVGAVNVAKG
610 620 630 640 650
TVQTGMDTTK TVLTGTKDTI YSGVTSAVNV AKGAVQTGLK TTQNIATGTK
660 670 680 690 700
NTFGSGVTSA VNVAKGAAQT GVDTAKTVLT GTKDTVTTGL MGAVNVAKGT
710 720 730 740 750
VQTSVDTTKT VLTGTKDTVC SGVTGAANVA KGAIQGGLDT TKSVLTGTKD
760 770 780 790 800
AVSTGLTGAV KLAKGTVQTG MDTTKTVLTG TKDAVCSGVT GAANVAKGAV
810 820 830 840 850
QMGVDTAKTV LTGTKDTVCS GVTGAANVAK GAVQTGLKTT QNIATGTKNT
860 870 880 890 900
LGSGVTGAAK VAKGAVQGGL DTTKSVLTGT KDAVSTGLTG AVNLAKGTVQ
910 920 930 940 950
TGVDTSKTVL TGTKDTVCSG VTGAVNVAKG TVQTGVDTAK TVLSGAKDAV
960 970 980 990 1000
TTGVTGAVNV AKGTVQTGVD ASKAVLMGTK DTVFSGVTGA MSMAKGAVQG
1010 1020 1030 1040 1050
GLDTTKTVLT GTKDAVSAGL MGSGNVATGA THTGLSTFQN WLPSTPATSW
1060 1070 1080 1090 1100
GGLTSSRTTD NGGEQTALSP QEAPFSGIST PPDVLSVGPE PAWEAAATTK
1110 1120 1130 1140 1150
GLATDVATFT QGAAPGREDT GLLATTHGPE EAPRLAMLQN ELEGLGDIFH
1160 1170 1180 1190 1200
PMNAEEQAQL AASQPGPKVL SAEQGSYFVR LGDLGPSFRQ RAFEHAVSHL
1210 1220 1230 1240 1250
QHGQFQARDT LAQLQDCFRL IEKAQQAPEG QPRLDQGSGA SAEDAAVQEE
1260 1270 1280 1290 1300
RDAGVLSRVC GLLRQLHTAY SGLVSSLQGL PAELQQPVGR ARHSLCELYG
1310 1320 1330 1340 1350
IVASAGSVEE LPAERLVQSR EGVHQAWQGL EQLLEGLQHN PPLSWLVGPF

ALPAGGQ
Length:1,357
Mass (Da):134,431
Last modified:August 21, 2007 - v2
Checksum:i24CCB9D3DD6B480D
GO
Isoform 2 (identifier: Q96Q06-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     720-720: C → CSGVTGAANVAKGAVQTGVDTAKTVLTGTKDTVCSGVTGAVNVAKGAVQTGLKTTQNIATGTKNTLG

Note: No experimental confirmation available.
Show »
Length:1,423
Mass (Da):140,675
Checksum:i15CBE032145C63E0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti263 – 2631G → S in BAB67774 (PubMed:11572484).Curated
Sequence conflicti668 – 6681A → V in BAB67774 (PubMed:11572484).Curated
Sequence conflicti734 – 7341I → V in BAB67774 (PubMed:11572484).Curated
Sequence conflicti819 – 8268CSGVTGAA → TTGLMGAV in BAB67774 (PubMed:11572484).Curated
Sequence conflicti832 – 8321A → T in BAB67774 (PubMed:11572484).Curated
Sequence conflicti836 – 8449GLKTTQNIA → SVDTTKTVL in BAB67774 (PubMed:11572484).Curated
Sequence conflicti849 – 8524NTLG → DTVC in BAB67774 (PubMed:11572484).Curated
Sequence conflicti883 – 8831A → T in BAB67774 (PubMed:11572484).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti124 – 1241V → A.1 Publication
Corresponds to variant rs4807597 [ dbSNP | Ensembl ].
VAR_061507
Natural varianti421 – 4211T → A.
Corresponds to variant rs55901236 [ dbSNP | Ensembl ].
VAR_061508
Natural varianti659 – 6591S → G.1 Publication
Corresponds to variant rs7260518 [ dbSNP | Ensembl ].
VAR_050483
Natural varianti761 – 7611K → N.1 Publication
Corresponds to variant rs7256387 [ dbSNP | Ensembl ].
VAR_061509
Natural varianti802 – 8021M → T.
Corresponds to variant rs7256712 [ dbSNP | Ensembl ].
VAR_061510
Natural varianti826 – 8261A → E.
Corresponds to variant rs7255187 [ dbSNP | Ensembl ].
VAR_061511
Natural varianti826 – 8261A → G.
Corresponds to variant rs7255187 [ dbSNP | Ensembl ].
VAR_061512
Natural varianti826 – 8261A → V.
Corresponds to variant rs7255187 [ dbSNP | Ensembl ].
VAR_061513
Natural varianti860 – 8601K → N.1 Publication
Corresponds to variant rs7259721 [ dbSNP | Ensembl ].
VAR_061514
Natural varianti1124 – 11241A → T.1 Publication
Corresponds to variant rs7251858 [ dbSNP | Ensembl ].
VAR_034637
Natural varianti1134 – 11341R → C.
Corresponds to variant rs7250947 [ dbSNP | Ensembl ].
VAR_050484

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei720 – 7201C → CSGVTGAANVAKGAVQTGVD TAKTVLTGTKDTVCSGVTGA VNVAKGAVQTGLKTTQNIAT GTKNTLG in isoform 2. 1 PublicationVSP_027278

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011498 Genomic DNA. No translation available.
AB067468 mRNA. Translation: BAB67774.1.
CCDSiCCDS45927.1. [Q96Q06-1]
RefSeqiNP_001073869.1. NM_001080400.1. [Q96Q06-1]
UniGeneiHs.591387.

Genome annotation databases

EnsembliENST00000301286; ENSP00000301286; ENSG00000167676. [Q96Q06-1]
GeneIDi729359.
KEGGihsa:729359.
UCSCiuc002mar.2. human. [Q96Q06-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011498 Genomic DNA. No translation available.
AB067468 mRNA. Translation: BAB67774.1.
CCDSiCCDS45927.1. [Q96Q06-1]
RefSeqiNP_001073869.1. NM_001080400.1. [Q96Q06-1]
UniGeneiHs.591387.

3D structure databases

ProteinModelPortaliQ96Q06.
SMRiQ96Q06. Positions 1151-1351.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi609760. 4 interactions.
IntActiQ96Q06. 2 interactions.
STRINGi9606.ENSP00000301286.

PTM databases

iPTMnetiQ96Q06.
PhosphoSiteiQ96Q06.

Polymorphism and mutation databases

BioMutaiPLIN4.
DMDMi156630940.

Proteomic databases

EPDiQ96Q06.
MaxQBiQ96Q06.
PaxDbiQ96Q06.
PeptideAtlasiQ96Q06.
PRIDEiQ96Q06.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301286; ENSP00000301286; ENSG00000167676. [Q96Q06-1]
GeneIDi729359.
KEGGihsa:729359.
UCSCiuc002mar.2. human. [Q96Q06-1]

Organism-specific databases

CTDi729359.
GeneCardsiPLIN4.
H-InvDBHIX0202699.
HGNCiHGNC:29393. PLIN4.
HPAiHPA044682.
HPA054657.
MIMi613247. gene.
neXtProtiNX_Q96Q06.
PharmGKBiPA165394042.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHSW. Eukaryota.
ENOG4112C4W. LUCA.
GeneTreeiENSGT00500000044795.
HOGENOMiHOG000113183.
HOVERGENiHBG099259.
InParanoidiQ96Q06.
KOiK20254.
OMAiQCGLDTS.
OrthoDBiEOG091G017D.
PhylomeDBiQ96Q06.
TreeFamiTF328397.

Miscellaneous databases

GenomeRNAii729359.
PROiQ96Q06.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000167676.
CleanExiHS_KIAA1881.
ExpressionAtlasiQ96Q06. baseline and differential.
GenevisibleiQ96Q06. HS.

Family and domain databases

InterProiIPR004279. Perilipin.
[Graphical view]
PANTHERiPTHR14024. PTHR14024. 3 hits.
PfamiPF03036. Perilipin. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPLIN4_HUMAN
AccessioniPrimary (citable) accession number: Q96Q06
Secondary accession number(s): A6NEI2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: August 21, 2007
Last modified: September 7, 2016
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.