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Protein

Trafficking protein particle complex subunit 9

Gene

TRAPPC9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions as an activator of NF-kappa-B through increased phosphorylation of the IKK complex. May function in neuronal cells differentiation. May play a role in vesicular transport from endoplasmic reticulum to Golgi.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Differentiation

Enzyme and pathway databases

ReactomeiR-HSA-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Trafficking protein particle complex subunit 9
Alternative name(s):
NIK- and IKBKB-binding protein
Tularik gene 1 protein
Gene namesi
Name:TRAPPC9
Synonyms:KIAA1882, NIBP
ORF Names:T1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:30832. TRAPPC9.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Golgi apparatus

Pathology & Biotechi

Involvement in diseasei

Mental retardation, autosomal recessive 13 (MRT13)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Brain magnetic resonance imaging of MRT13 patients indicates the presence of mild cerebral white matter hypoplasia. Microcephaly is present in some but not all affected individuals.
See also OMIM:613192

Keywords - Diseasei

Mental retardation

Organism-specific databases

MalaCardsiTRAPPC9.
MIMi613192. phenotype.
Orphaneti88616. Autosomal recessive non-syndromic intellectual disability.
352530. Intellectual disability - obesity - brain malformations - facial dysmorphism.
PharmGKBiPA162406921.

Polymorphism and mutation databases

BioMutaiTRAPPC9.
DMDMi190359999.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11481148Trafficking protein particle complex subunit 9PRO_0000341586Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei953 – 9531PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96Q05.
MaxQBiQ96Q05.
PaxDbiQ96Q05.
PRIDEiQ96Q05.

PTM databases

iPTMnetiQ96Q05.
PhosphoSiteiQ96Q05.

Expressioni

Tissue specificityi

Expressed at high levels in muscle and kidney and to a lower extent in brain, heart and placenta.1 Publication

Gene expression databases

BgeeiQ96Q05.
ExpressionAtlasiQ96Q05. baseline and differential.
GenevisibleiQ96Q05. HS.

Organism-specific databases

HPAiHPA025225.
HPA025246.
HPA026579.
HPA028262.

Interactioni

Subunit structurei

Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12. Directly interacts with IKBKB and MAP3K14.2 Publications

Protein-protein interaction databases

BioGridi123730. 37 interactions.
IntActiQ96Q05. 4 interactions.
MINTiMINT-6784888.
STRINGi9606.ENSP00000373979.

Structurei

3D structure databases

ProteinModelPortaliQ96Q05.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NIBP family.Curated

Phylogenomic databases

eggNOGiKOG1953. Eukaryota.
ENOG410YEPC. LUCA.
GeneTreeiENSGT00390000006486.
HOVERGENiHBG108595.
InParanoidiQ96Q05.
OMAiSGPFLFT.
OrthoDBiEOG7RBZ7K.
PhylomeDBiQ96Q05.
TreeFamiTF314341.

Family and domain databases

InterProiIPR013935. TRAPP_II_complex_Trs120.
[Graphical view]
PANTHERiPTHR21512. PTHR21512. 1 hit.
PfamiPF08626. TRAPPC9-Trs120. 3 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96Q05-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSVPDYMQCA EDHQTLLVVV QPVGIVSEEN FFRIYKRICS VSQISVRDSQ
60 70 80 90 100
RVLYIRYRHH YPPENNEWGD FQTHRKVVGL ITITDCFSAK DWPQTFEKFH
110 120 130 140 150
VQKEIYGSTL YDSRLFVFGL QGEIVEQPRT DVAFYPNYED CQTVEKRIED
160 170 180 190 200
FIESLFIVLE SKRLDRATDK SGDKIPLLCV PFEKKDFVGL DTDSRHYKKR
210 220 230 240 250
CQGRMRKHVG DLCLQAGMLQ DSLVHYHMSV ELLRSVNDFL WLGAALEGLC
260 270 280 290 300
SASVIYHYPG GTGGKSGARR FQGSTLPAEA ANRHRPGAQE VLIDPGALTT
310 320 330 340 350
NGINPDTSTE IGRAKNCLSP EDIIDKYKEA ISYYSKYKNA GVIELEACIK
360 370 380 390 400
AVRVLAIQKR SMEASEFLQN AVYINLRQLS EEEKIQRYSI LSELYELIGF
410 420 430 440 450
HRKSAFFKRV AAMQCVAPSI AEPGWRACYK LLLETLPGYS LSLDPKDFSR
460 470 480 490 500
GTHRGWAAVQ MRLLHELVYA SRRMGNPALS VRHLSFLLQT MLDFLSDQEK
510 520 530 540 550
KDVAQSLENY TSKCPGTMEP IALPGGLTLP PVPFTKLPIV RHVKLLNLPA
560 570 580 590 600
SLRPHKMKSL LGQNVSTKSP FIYSPIIAHN RGEERNKKID FQWVQGDVCE
610 620 630 640 650
VQLMVYNPMP FELRVENMGL LTSGVEFESL PAALSLPAES GLYPVTLVGV
660 670 680 690 700
PQTTGTITVN GYHTTVFGVF SDCLLDNLPG IKTSGSTVEV IPALPRLQIS
710 720 730 740 750
TSLPRSAHSL QPSSGDEIST NVSVQLYNGE SQQLIIKLEN IGMEPLEKLE
760 770 780 790 800
VTSKVLTTKE KLYGDFLSWK LEETLAQFPL QPGKVATFTI NIKVKLDFSC
810 820 830 840 850
QENLLQDLSD DGISVSGFPL SSPFRQVVRP RVEGKPVNPP ESNKAGDYSH
860 870 880 890 900
VKTLEAVLNF KYSGGPGHTE GYYRNLSLGL HVEVEPSVFF TRVSTLPATS
910 920 930 940 950
TRQCHLLLDV FNSTEHELTV STRSSEALIL HAGECQRMAI QVDKFNFESF
960 970 980 990 1000
PESPGEKGQF ANPKQLEEER REARGLEIHS KLGICWRIPS LKRSGEASVE
1010 1020 1030 1040 1050
GLLNQLVLEH LQLAPLQWDV LVDGQPCDRE AVAACQVGDP VRLEVRLTNR
1060 1070 1080 1090 1100
SPRSVGPFAL TVVPFQDHQN GVHNYDLHDT VSFVGSSTFY LDAVQPSGQS
1110 1120 1130 1140
ACLGALLFLY TGDFFLHIRF HEDSTSKELP PSWFCLPSVH VCALEAQA
Length:1,148
Mass (Da):128,530
Last modified:June 10, 2008 - v2
Checksum:i532932462A6853CC
GO
Isoform 2 (identifier: Q96Q05-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MVPAGDQDRA...RALKDWDFKM

Note: No experimental confirmation available.
Show »
Length:1,246
Mass (Da):139,437
Checksum:i657FEFF8EB0E8008
GO
Isoform 3 (identifier: Q96Q05-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     286-294: Missing.

Show »
Length:1,139
Mass (Da):127,607
Checksum:i9A75186A0673E4AD
GO

Sequence cautioni

The sequence AAH06206.3 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAB55299.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAB67775.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti505 – 5051Missing in CAH56384 (PubMed:17974005).Curated
Sequence conflicti539 – 5391I → V in BAC87600 (PubMed:14702039).Curated
Sequence conflicti669 – 6691V → E in BAB55299 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MVPAGDQDRAPHRGKPAQAG ARTSRASRALRSWRRSQAAR ATVTHPRGGHDRGSHGGYRE GHRGCRRDPQWASAGPPPLS FTEEVKFELRALKDWDFKM in isoform 2. 1 PublicationVSP_034349
Alternative sequencei286 – 2949Missing in isoform 3. 1 PublicationVSP_034350

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB067469 mRNA. Translation: BAB67775.1. Different initiation.
AK027689 mRNA. Translation: BAB55299.1. Different initiation.
AK128755 mRNA. Translation: BAC87600.1.
BC003650 mRNA. Translation: AAH03650.3.
BC006206 mRNA. Translation: AAH06206.3. Different initiation.
BC065288 mRNA. Translation: AAH65288.1.
AL833973 mRNA. Translation: CAH56384.1.
AY190606 mRNA. Translation: AAO38740.1.
AY630619 mRNA. Translation: AAV31908.1.
CCDSiCCDS34946.1. [Q96Q05-2]
CCDS55278.1. [Q96Q05-1]
RefSeqiNP_001153844.1. NM_001160372.3. [Q96Q05-1]
NP_113654.4. NM_031466.7. [Q96Q05-2]
XP_005251134.1. XM_005251077.3. [Q96Q05-1]
XP_011515631.1. XM_011517329.1.
UniGeneiHs.654911.
Hs.733622.

Genome annotation databases

EnsembliENST00000389328; ENSP00000373979; ENSG00000167632. [Q96Q05-2]
ENST00000438773; ENSP00000405060; ENSG00000167632. [Q96Q05-1]
GeneIDi83696.
KEGGihsa:83696.
UCSCiuc003yvh.2. human. [Q96Q05-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB067469 mRNA. Translation: BAB67775.1. Different initiation.
AK027689 mRNA. Translation: BAB55299.1. Different initiation.
AK128755 mRNA. Translation: BAC87600.1.
BC003650 mRNA. Translation: AAH03650.3.
BC006206 mRNA. Translation: AAH06206.3. Different initiation.
BC065288 mRNA. Translation: AAH65288.1.
AL833973 mRNA. Translation: CAH56384.1.
AY190606 mRNA. Translation: AAO38740.1.
AY630619 mRNA. Translation: AAV31908.1.
CCDSiCCDS34946.1. [Q96Q05-2]
CCDS55278.1. [Q96Q05-1]
RefSeqiNP_001153844.1. NM_001160372.3. [Q96Q05-1]
NP_113654.4. NM_031466.7. [Q96Q05-2]
XP_005251134.1. XM_005251077.3. [Q96Q05-1]
XP_011515631.1. XM_011517329.1.
UniGeneiHs.654911.
Hs.733622.

3D structure databases

ProteinModelPortaliQ96Q05.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123730. 37 interactions.
IntActiQ96Q05. 4 interactions.
MINTiMINT-6784888.
STRINGi9606.ENSP00000373979.

PTM databases

iPTMnetiQ96Q05.
PhosphoSiteiQ96Q05.

Polymorphism and mutation databases

BioMutaiTRAPPC9.
DMDMi190359999.

Proteomic databases

EPDiQ96Q05.
MaxQBiQ96Q05.
PaxDbiQ96Q05.
PRIDEiQ96Q05.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000389328; ENSP00000373979; ENSG00000167632. [Q96Q05-2]
ENST00000438773; ENSP00000405060; ENSG00000167632. [Q96Q05-1]
GeneIDi83696.
KEGGihsa:83696.
UCSCiuc003yvh.2. human. [Q96Q05-1]

Organism-specific databases

CTDi83696.
GeneCardsiTRAPPC9.
H-InvDBHIX0019731.
HGNCiHGNC:30832. TRAPPC9.
HPAiHPA025225.
HPA025246.
HPA026579.
HPA028262.
MalaCardsiTRAPPC9.
MIMi611966. gene.
613192. phenotype.
neXtProtiNX_Q96Q05.
Orphaneti88616. Autosomal recessive non-syndromic intellectual disability.
352530. Intellectual disability - obesity - brain malformations - facial dysmorphism.
PharmGKBiPA162406921.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1953. Eukaryota.
ENOG410YEPC. LUCA.
GeneTreeiENSGT00390000006486.
HOVERGENiHBG108595.
InParanoidiQ96Q05.
OMAiSGPFLFT.
OrthoDBiEOG7RBZ7K.
PhylomeDBiQ96Q05.
TreeFamiTF314341.

Enzyme and pathway databases

ReactomeiR-HSA-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.

Miscellaneous databases

ChiTaRSiTRAPPC9. human.
GenomeRNAii83696.
PROiQ96Q05.
SOURCEiSearch...

Gene expression databases

BgeeiQ96Q05.
ExpressionAtlasiQ96Q05. baseline and differential.
GenevisibleiQ96Q05. HS.

Family and domain databases

InterProiIPR013935. TRAPP_II_complex_Trs120.
[Graphical view]
PANTHERiPTHR21512. PTHR21512. 1 hit.
PfamiPF08626. TRAPPC9-Trs120. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins."
    Nagase T., Kikuno R., Ohara O.
    DNA Res. 8:179-187(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Cerebellum and Teratocarcinoma.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 149-1148 (ISOFORM 3).
    Tissue: Lung and Skin.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 198-1148 (ISOFORM 1).
    Tissue: Uterus.
  5. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 205-1148 (ISOFORM 1).
  6. "NIBP, a novel NIK and IKK(beta)-binding protein that enhances NF-(kappa)B activation."
    Hu W.-H., Pendergast J.S., Mo X.-M., Brambilla R., Bracchi-Ricard V., Li F., Walters W.M., Blits B., He L., Schaal S.M., Bethea J.R.
    J. Biol. Chem. 280:29233-29241(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 938-1148 (ISOFORM 1), FUNCTION, INTERACTION WITH IKBKB AND MAP3K14, TISSUE SPECIFICITY.
    Tissue: Brain.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "A truncating mutation of TRAPPC9 is associated with autosomal-recessive intellectual disability and postnatal microcephaly."
    Mochida G.H., Mahajnah M., Hill A.D., Basel-Vanagaite L., Gleason D., Hill R.S., Bodell A., Crosier M., Straussberg R., Walsh C.A.
    Am. J. Hum. Genet. 85:897-902(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN MRT13.
  9. "Identification of mutations in TRAPPC9, which encodes the NIK- and IKK-beta-binding protein, in nonsyndromic autosomal-recessive mental retardation."
    Mir A., Kaufman L., Noor A., Motazacker M.M., Jamil T., Azam M., Kahrizi K., Rafiq M.A., Weksberg R., Nasr T., Naeem F., Tzschach A., Kuss A.W., Ishak G.E., Doherty D., Ropers H.H., Barkovich A.J., Najmabadi H., Ayub M., Vincent J.B.
    Am. J. Hum. Genet. 85:909-915(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN MRT13.
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. "C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking."
    Scrivens P.J., Noueihed B., Shahrzad N., Hul S., Brunet S., Sacher M.
    Mol. Biol. Cell 22:2083-2093(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN TRAPP COMPLEX.

Entry informationi

Entry nameiTPPC9_HUMAN
AccessioniPrimary (citable) accession number: Q96Q05
Secondary accession number(s): Q4VTT3
, Q658K7, Q6P149, Q6ZQT3, Q7L5C4, Q86Y21, Q96SL2, Q9BQA2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: June 8, 2016
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.