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Q96Q04

- LMTK3_HUMAN

UniProt

Q96Q04 - LMTK3_HUMAN

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Protein

Serine/threonine-protein kinase LMTK3

Gene

LMTK3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei164 – 1641ATPPROSITE-ProRule annotation
Active sitei266 – 2661Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi139 – 1479ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: UniProtKB-KW

GO - Biological processi

  1. negative regulation of phosphatase activity Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase LMTK3 (EC:2.7.11.1)
Alternative name(s):
Lemur tyrosine kinase 3
Gene namesi
Name:LMTK3
Synonyms:KIAA1883, TYKLM3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:19295. LMTK3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei40 – 6021HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 14601440Serine/threonine-protein kinase LMTK3PRO_0000259460Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi1081 – 10811N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1405 – 14051N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ96Q04.
PRIDEiQ96Q04.

PTM databases

PhosphoSiteiQ96Q04.

Expressioni

Gene expression databases

BgeeiQ96Q04.
CleanExiHS_LMTK3.
GenevestigatoriQ96Q04.

Organism-specific databases

HPAiHPA040203.

Interactioni

Protein-protein interaction databases

IntActiQ96Q04. 2 interactions.
MINTiMINT-1391188.

Structurei

3D structure databases

ProteinModelPortaliQ96Q04.
SMRiQ96Q04. Positions 79-405.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini133 – 411279Protein kinasePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi416 – 14571042Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00640000091449.
HOGENOMiHOG000170369.
HOVERGENiHBG081921.
InParanoidiQ96Q04.
KOiK08899.
OrthoDBiEOG708VZ8.
PhylomeDBiQ96Q04.
TreeFamiTF332280.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96Q04-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPAPGALILL AAVSASGCLA SPAHPDGFAL GRAPLAPPYA VVLISCSGLL
60 70 80 90 100
AFIFLLLTCL CCKRGDVGFK EFENPEGEDC SGEYTPPAEE TSSSQSLPDV
110 120 130 140 150
YILPLAEVSL PMPAPQPSHS DMTTPLGLSR QHLSYLQEIG SGWFGKVILG
160 170 180 190 200
EIFSDYTPAQ VVVKELRASA GPLEQRKFIS EAQPYRSLQH PNVLQCLGLC
210 220 230 240 250
VETLPFLLIM EFCQLGDLKR YLRAQRPPEG LSPELPPRDL RTLQRMGLEI
260 270 280 290 300
ARGLAHLHSH NYVHSDLALR NCLLTSDLTV RIGDYGLAHS NYKEDYYLTP
310 320 330 340 350
ERLWIPLRWA APELLGELHG TFMVVDQSRE SNIWSLGVTL WELFEFGAQP
360 370 380 390 400
YRHLSDEEVL AFVVRQQHVK LARPRLKLPY ADYWYDILQS CWRPPAQRPS
410 420 430 440 450
ASDLQLQLTY LLSERPPRPP PPPPPPRDGP FPWPWPPAHS APRPGTLSSP
460 470 480 490 500
FPLLDGFPGA DPDDVLTVTE SSRGLNLECL WEKARRGAGR GGGAPAWQPA
510 520 530 540 550
SAPPAPHANP SNPFYEALST PSVLPVISAR SPSVSSEYYI RLEEHGSPPE
560 570 580 590 600
PLFPNDWDPL DPGVPAPQAP QAPSEVPQLV SETWASPLFP APRPFPAQSS
610 620 630 640 650
ASGSFLLSGW DPEGRGAGET LAGDPAEVLG ERGTAPWVEE EEEEEEGSSP
660 670 680 690 700
GEDSSSLGGG PSRRGPLPCP LCSREGACSC LPLERGDAVA GWGGHPALGC
710 720 730 740 750
PHPPEDDSSL RAERGSLADL PMAPPASAPP EFLDPLMGAA APQYPGRGPP
760 770 780 790 800
PAPPPPPPPP RAPADPAASP DPPSAVASPG SGLSSPGPKP GDSGYETETP
810 820 830 840 850
FSPEGAFPGG GAAEEEGVPR PRAPPEPPDP GAPRPPPDPG PLPLPGPREK
860 870 880 890 900
PTFVVQVSTE QLLMSLREDV TRNLLGEKGA TARETGPRKA GRGPGNREKV
910 920 930 940 950
PGLNRDPTVL GNGKQAPSLS LPVNGVTVLE NGDQRAPGIE EKAAENGALG
960 970 980 990 1000
SPEREEKVLE NGELTPPRRE EKALENGELR SPEAGEKVLV NGGLTPPKSE
1010 1020 1030 1040 1050
DKVSENGGLR FPRNTERPPE TGPWRAPGPW EKTPESWGPA PTIGEPAPET
1060 1070 1080 1090 1100
SLERAPAPSA VVSSRNGGET APGPLGPAPK NGTLEPGTER RAPETGGAPR
1110 1120 1130 1140 1150
APGAGRLDLG SGGRAPVGTG TAPGGGPGSG VDAKAGWVDN TRPQPPPPPL
1160 1170 1180 1190 1200
PPPPEAQPRR LEPAPPRARP EVAPEGEPGA PDSRAGGDTA LSGDGDPPKP
1210 1220 1230 1240 1250
ERKGPEMPRL FLDLGPPQGN SEQIKARLSR LSLALPPLTL TPFPGPGPRR
1260 1270 1280 1290 1300
PPWEGADAGA AGGEAGGAGA PGPAEEDGED EDEDEEEDEE AAAPGAAAGP
1310 1320 1330 1340 1350
RGPGRARAAP VPVVVSSADA DAARPLRGLL KSPRGADEPE DSELERKRKM
1360 1370 1380 1390 1400
VSFHGDVTVY LFDQETPTNE LSVQAPPEGD TDPSTPPAPP TPPHPATPGD
1410 1420 1430 1440 1450
GFPSNDSGFG GSFEWAEDFP LLPPPGPPLC FSRFSVSPAL ETPGPPARAP
1460
DARPAGPVEN
Length:1,460
Mass (Da):153,661
Last modified:October 31, 2006 - v2
Checksum:iFF99FBFD873C73D3
GO

Sequence cautioni

The sequence AAH36690.1 differs from that shown. Reason: Frameshift at position 809. Curated
The sequence BAB67776.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti774 – 7741S → A in AAH36690. (PubMed:15489334)Curated
Sequence conflicti1398 – 13981P → R in AAH36690. (PubMed:15489334)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti900 – 9001V → L.
Corresponds to variant rs1643478 [ dbSNP | Ensembl ].
VAR_057116
Natural varianti929 – 9291L → V.
Corresponds to variant rs1643478 [ dbSNP | Ensembl ].
VAR_028943

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB067470 mRNA. Translation: BAB67776.1. Different initiation.
AC008403 Genomic DNA. No translation available.
BC036690 mRNA. Translation: AAH36690.1. Frameshift.
RefSeqiXP_006723058.1. XM_006722995.1.
UniGeneiHs.207426.

Genome annotation databases

EnsembliENST00000600059; ENSP00000472020; ENSG00000142235.
GeneIDi114783.
KEGGihsa:114783.
UCSCiuc002pjk.3. human.

Polymorphism databases

DMDMi117949603.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB067470 mRNA. Translation: BAB67776.1 . Different initiation.
AC008403 Genomic DNA. No translation available.
BC036690 mRNA. Translation: AAH36690.1 . Frameshift.
RefSeqi XP_006723058.1. XM_006722995.1.
UniGenei Hs.207426.

3D structure databases

ProteinModelPortali Q96Q04.
SMRi Q96Q04. Positions 79-405.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q96Q04. 2 interactions.
MINTi MINT-1391188.

PTM databases

PhosphoSitei Q96Q04.

Polymorphism databases

DMDMi 117949603.

Proteomic databases

PaxDbi Q96Q04.
PRIDEi Q96Q04.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000600059 ; ENSP00000472020 ; ENSG00000142235 .
GeneIDi 114783.
KEGGi hsa:114783.
UCSCi uc002pjk.3. human.

Organism-specific databases

CTDi 114783.
GeneCardsi GC19M048988.
H-InvDB HIX0015294.
HGNCi HGNC:19295. LMTK3.
HPAi HPA040203.
neXtProti NX_Q96Q04.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00640000091449.
HOGENOMi HOG000170369.
HOVERGENi HBG081921.
InParanoidi Q96Q04.
KOi K08899.
OrthoDBi EOG708VZ8.
PhylomeDBi Q96Q04.
TreeFami TF332280.

Miscellaneous databases

ChiTaRSi LMTK3. human.
GenomeRNAii 114783.
PROi Q96Q04.

Gene expression databases

Bgeei Q96Q04.
CleanExi HS_LMTK3.
Genevestigatori Q96Q04.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
[Graphical view ]
Pfami PF07714. Pkinase_Tyr. 1 hit.
[Graphical view ]
PRINTSi PR00109. TYRKINASE.
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins."
    Nagase T., Kikuno R., Ohara O.
    DNA Res. 8:179-187(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 774-1460.
    Tissue: Brain.

Entry informationi

Entry nameiLMTK3_HUMAN
AccessioniPrimary (citable) accession number: Q96Q04
Secondary accession number(s): Q4G0U1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: November 26, 2014
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3