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Protein

Serine/threonine-protein kinase LMTK3

Gene

LMTK3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription (PubMed:21602804). Involved in endocytic trafficking of N-methyl-D-aspartate receptors (NMDAR) in neurons (By similarity).By similarity1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.1 Publication

Cofactori

Mg2+1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei164ATPPROSITE-ProRule annotation1
Active sitei266Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi139 – 147ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

  • negative regulation of phosphatase activity Source: UniProtKB

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase LMTK3 (EC:2.7.11.11 Publication)
Alternative name(s):
Lemur tyrosine kinase 3
Gene namesi
Name:LMTK3
Synonyms:KIAA1883, TYKLM3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000142235.8.
HGNCiHGNC:19295. LMTK3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei40 – 60HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell projection, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi114783.
OpenTargetsiENSG00000142235.

Polymorphism and mutation databases

DMDMi117949603.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000025946021 – 1460Serine/threonine-protein kinase LMTK3Add BLAST1440

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei232PhosphoserineBy similarity1
Modified residuei490Omega-N-methylarginineBy similarity1
Modified residuei531PhosphoserineBy similarity1
Modified residuei535PhosphoserineBy similarity1
Modified residuei981PhosphoserineBy similarity1
Glycosylationi1081N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1405N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Methylation, Phosphoprotein

Proteomic databases

EPDiQ96Q04.
PaxDbiQ96Q04.
PeptideAtlasiQ96Q04.
PRIDEiQ96Q04.

PTM databases

iPTMnetiQ96Q04.
PhosphoSitePlusiQ96Q04.

Expressioni

Gene expression databases

BgeeiENSG00000142235.
CleanExiHS_LMTK3.
ExpressionAtlasiQ96Q04. baseline and differential.
GenevisibleiQ96Q04. HS.

Organism-specific databases

HPAiHPA040203.

Interactioni

Subunit structurei

Interacts with ESR1 (PubMed:21602804). Interacts with AP-2 complex subunit alpha (By similarity).By similarity1 Publication

Protein-protein interaction databases

BioGridi125345. 4 interactors.
IntActiQ96Q04. 2 interactors.
MINTiMINT-1391188.

Structurei

3D structure databases

ProteinModelPortaliQ96Q04.
SMRiQ96Q04.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini133 – 411Protein kinasePROSITE-ProRule annotationAdd BLAST279

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi416 – 1457Pro-richAdd BLAST1042

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGQE. Eukaryota.
ENOG410XQFM. LUCA.
GeneTreeiENSGT00640000091449.
HOGENOMiHOG000170369.
HOVERGENiHBG081921.
InParanoidiQ96Q04.
PhylomeDBiQ96Q04.
TreeFamiTF332280.

Family and domain databases

InterProiView protein in InterPro
IPR011009. Kinase-like_dom_sf.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
PfamiView protein in Pfam
PF07714. Pkinase_Tyr. 1 hit.
PRINTSiPR00109. TYRKINASE.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96Q04-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAPGALILL AAVSASGCLA SPAHPDGFAL GRAPLAPPYA VVLISCSGLL
60 70 80 90 100
AFIFLLLTCL CCKRGDVGFK EFENPEGEDC SGEYTPPAEE TSSSQSLPDV
110 120 130 140 150
YILPLAEVSL PMPAPQPSHS DMTTPLGLSR QHLSYLQEIG SGWFGKVILG
160 170 180 190 200
EIFSDYTPAQ VVVKELRASA GPLEQRKFIS EAQPYRSLQH PNVLQCLGLC
210 220 230 240 250
VETLPFLLIM EFCQLGDLKR YLRAQRPPEG LSPELPPRDL RTLQRMGLEI
260 270 280 290 300
ARGLAHLHSH NYVHSDLALR NCLLTSDLTV RIGDYGLAHS NYKEDYYLTP
310 320 330 340 350
ERLWIPLRWA APELLGELHG TFMVVDQSRE SNIWSLGVTL WELFEFGAQP
360 370 380 390 400
YRHLSDEEVL AFVVRQQHVK LARPRLKLPY ADYWYDILQS CWRPPAQRPS
410 420 430 440 450
ASDLQLQLTY LLSERPPRPP PPPPPPRDGP FPWPWPPAHS APRPGTLSSP
460 470 480 490 500
FPLLDGFPGA DPDDVLTVTE SSRGLNLECL WEKARRGAGR GGGAPAWQPA
510 520 530 540 550
SAPPAPHANP SNPFYEALST PSVLPVISAR SPSVSSEYYI RLEEHGSPPE
560 570 580 590 600
PLFPNDWDPL DPGVPAPQAP QAPSEVPQLV SETWASPLFP APRPFPAQSS
610 620 630 640 650
ASGSFLLSGW DPEGRGAGET LAGDPAEVLG ERGTAPWVEE EEEEEEGSSP
660 670 680 690 700
GEDSSSLGGG PSRRGPLPCP LCSREGACSC LPLERGDAVA GWGGHPALGC
710 720 730 740 750
PHPPEDDSSL RAERGSLADL PMAPPASAPP EFLDPLMGAA APQYPGRGPP
760 770 780 790 800
PAPPPPPPPP RAPADPAASP DPPSAVASPG SGLSSPGPKP GDSGYETETP
810 820 830 840 850
FSPEGAFPGG GAAEEEGVPR PRAPPEPPDP GAPRPPPDPG PLPLPGPREK
860 870 880 890 900
PTFVVQVSTE QLLMSLREDV TRNLLGEKGA TARETGPRKA GRGPGNREKV
910 920 930 940 950
PGLNRDPTVL GNGKQAPSLS LPVNGVTVLE NGDQRAPGIE EKAAENGALG
960 970 980 990 1000
SPEREEKVLE NGELTPPRRE EKALENGELR SPEAGEKVLV NGGLTPPKSE
1010 1020 1030 1040 1050
DKVSENGGLR FPRNTERPPE TGPWRAPGPW EKTPESWGPA PTIGEPAPET
1060 1070 1080 1090 1100
SLERAPAPSA VVSSRNGGET APGPLGPAPK NGTLEPGTER RAPETGGAPR
1110 1120 1130 1140 1150
APGAGRLDLG SGGRAPVGTG TAPGGGPGSG VDAKAGWVDN TRPQPPPPPL
1160 1170 1180 1190 1200
PPPPEAQPRR LEPAPPRARP EVAPEGEPGA PDSRAGGDTA LSGDGDPPKP
1210 1220 1230 1240 1250
ERKGPEMPRL FLDLGPPQGN SEQIKARLSR LSLALPPLTL TPFPGPGPRR
1260 1270 1280 1290 1300
PPWEGADAGA AGGEAGGAGA PGPAEEDGED EDEDEEEDEE AAAPGAAAGP
1310 1320 1330 1340 1350
RGPGRARAAP VPVVVSSADA DAARPLRGLL KSPRGADEPE DSELERKRKM
1360 1370 1380 1390 1400
VSFHGDVTVY LFDQETPTNE LSVQAPPEGD TDPSTPPAPP TPPHPATPGD
1410 1420 1430 1440 1450
GFPSNDSGFG GSFEWAEDFP LLPPPGPPLC FSRFSVSPAL ETPGPPARAP
1460
DARPAGPVEN
Length:1,460
Mass (Da):153,661
Last modified:October 31, 2006 - v2
Checksum:iFF99FBFD873C73D3
GO

Sequence cautioni

The sequence AAH36690 differs from that shown. Reason: Frameshift at position 809.Curated
The sequence BAB67776 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti774S → A in AAH36690 (PubMed:15489334).Curated1
Sequence conflicti1398P → R in AAH36690 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057116900V → L. Corresponds to variant dbSNP:rs1643478Ensembl.1
Natural variantiVAR_028943929L → V. Corresponds to variant dbSNP:rs1643478Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB067470 mRNA. Translation: BAB67776.1. Different initiation.
AC008403 Genomic DNA. No translation available.
BC036690 mRNA. Translation: AAH36690.1. Frameshift.
UniGeneiHs.207426.

Genome annotation databases

EnsembliENST00000600059; ENSP00000472020; ENSG00000142235.
UCSCiuc061aua.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiLMTK3_HUMAN
AccessioniPrimary (citable) accession number: Q96Q04
Secondary accession number(s): Q4G0U1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: November 22, 2017
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  5. SIMILARITY comments
    Index of protein domains and families