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Q96Q04

- LMTK3_HUMAN

UniProt

Q96Q04 - LMTK3_HUMAN

Protein

Serine/threonine-protein kinase LMTK3

Gene

LMTK3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 2 (31 Oct 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei164 – 1641ATPPROSITE-ProRule annotation
    Active sitei266 – 2661Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi139 – 1479ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein serine/threonine kinase activity Source: UniProtKB-KW
    3. protein tyrosine kinase activity Source: InterPro

    GO - Biological processi

    1. negative regulation of phosphatase activity Source: UniProtKB

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein kinase LMTK3 (EC:2.7.11.1)
    Alternative name(s):
    Lemur tyrosine kinase 3
    Gene namesi
    Name:LMTK3
    Synonyms:KIAA1883, TYKLM3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:19295. LMTK3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 14601440Serine/threonine-protein kinase LMTK3PRO_0000259460Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi1081 – 10811N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1405 – 14051N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ96Q04.
    PRIDEiQ96Q04.

    PTM databases

    PhosphoSiteiQ96Q04.

    Expressioni

    Gene expression databases

    BgeeiQ96Q04.
    CleanExiHS_LMTK3.
    GenevestigatoriQ96Q04.

    Organism-specific databases

    HPAiHPA040203.

    Interactioni

    Protein-protein interaction databases

    IntActiQ96Q04. 2 interactions.
    MINTiMINT-1391188.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96Q04.
    SMRiQ96Q04. Positions 79-405.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei40 – 6021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini133 – 411279Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi416 – 14571042Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Tyr protein kinase family.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000170369.
    HOVERGENiHBG081921.
    InParanoidiQ96Q04.
    KOiK08899.
    OrthoDBiEOG708VZ8.
    PhylomeDBiQ96Q04.
    TreeFamiTF332280.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008266. Tyr_kinase_AS.
    [Graphical view]
    PfamiPF07714. Pkinase_Tyr. 1 hit.
    [Graphical view]
    PRINTSiPR00109. TYRKINASE.
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q96Q04-1 [UniParc]FASTAAdd to Basket

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    MPAPGALILL AAVSASGCLA SPAHPDGFAL GRAPLAPPYA VVLISCSGLL     50
    AFIFLLLTCL CCKRGDVGFK EFENPEGEDC SGEYTPPAEE TSSSQSLPDV 100
    YILPLAEVSL PMPAPQPSHS DMTTPLGLSR QHLSYLQEIG SGWFGKVILG 150
    EIFSDYTPAQ VVVKELRASA GPLEQRKFIS EAQPYRSLQH PNVLQCLGLC 200
    VETLPFLLIM EFCQLGDLKR YLRAQRPPEG LSPELPPRDL RTLQRMGLEI 250
    ARGLAHLHSH NYVHSDLALR NCLLTSDLTV RIGDYGLAHS NYKEDYYLTP 300
    ERLWIPLRWA APELLGELHG TFMVVDQSRE SNIWSLGVTL WELFEFGAQP 350
    YRHLSDEEVL AFVVRQQHVK LARPRLKLPY ADYWYDILQS CWRPPAQRPS 400
    ASDLQLQLTY LLSERPPRPP PPPPPPRDGP FPWPWPPAHS APRPGTLSSP 450
    FPLLDGFPGA DPDDVLTVTE SSRGLNLECL WEKARRGAGR GGGAPAWQPA 500
    SAPPAPHANP SNPFYEALST PSVLPVISAR SPSVSSEYYI RLEEHGSPPE 550
    PLFPNDWDPL DPGVPAPQAP QAPSEVPQLV SETWASPLFP APRPFPAQSS 600
    ASGSFLLSGW DPEGRGAGET LAGDPAEVLG ERGTAPWVEE EEEEEEGSSP 650
    GEDSSSLGGG PSRRGPLPCP LCSREGACSC LPLERGDAVA GWGGHPALGC 700
    PHPPEDDSSL RAERGSLADL PMAPPASAPP EFLDPLMGAA APQYPGRGPP 750
    PAPPPPPPPP RAPADPAASP DPPSAVASPG SGLSSPGPKP GDSGYETETP 800
    FSPEGAFPGG GAAEEEGVPR PRAPPEPPDP GAPRPPPDPG PLPLPGPREK 850
    PTFVVQVSTE QLLMSLREDV TRNLLGEKGA TARETGPRKA GRGPGNREKV 900
    PGLNRDPTVL GNGKQAPSLS LPVNGVTVLE NGDQRAPGIE EKAAENGALG 950
    SPEREEKVLE NGELTPPRRE EKALENGELR SPEAGEKVLV NGGLTPPKSE 1000
    DKVSENGGLR FPRNTERPPE TGPWRAPGPW EKTPESWGPA PTIGEPAPET 1050
    SLERAPAPSA VVSSRNGGET APGPLGPAPK NGTLEPGTER RAPETGGAPR 1100
    APGAGRLDLG SGGRAPVGTG TAPGGGPGSG VDAKAGWVDN TRPQPPPPPL 1150
    PPPPEAQPRR LEPAPPRARP EVAPEGEPGA PDSRAGGDTA LSGDGDPPKP 1200
    ERKGPEMPRL FLDLGPPQGN SEQIKARLSR LSLALPPLTL TPFPGPGPRR 1250
    PPWEGADAGA AGGEAGGAGA PGPAEEDGED EDEDEEEDEE AAAPGAAAGP 1300
    RGPGRARAAP VPVVVSSADA DAARPLRGLL KSPRGADEPE DSELERKRKM 1350
    VSFHGDVTVY LFDQETPTNE LSVQAPPEGD TDPSTPPAPP TPPHPATPGD 1400
    GFPSNDSGFG GSFEWAEDFP LLPPPGPPLC FSRFSVSPAL ETPGPPARAP 1450
    DARPAGPVEN 1460
    Length:1,460
    Mass (Da):153,661
    Last modified:October 31, 2006 - v2
    Checksum:iFF99FBFD873C73D3
    GO

    Sequence cautioni

    The sequence AAH36690.1 differs from that shown. Reason: Frameshift at position 809.
    The sequence BAB67776.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti774 – 7741S → A in AAH36690. (PubMed:15489334)Curated
    Sequence conflicti1398 – 13981P → R in AAH36690. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti900 – 9001V → L.
    Corresponds to variant rs1643478 [ dbSNP | Ensembl ].
    VAR_057116
    Natural varianti929 – 9291L → V.
    Corresponds to variant rs1643478 [ dbSNP | Ensembl ].
    VAR_028943

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB067470 mRNA. Translation: BAB67776.1. Different initiation.
    AC008403 Genomic DNA. No translation available.
    BC036690 mRNA. Translation: AAH36690.1. Frameshift.
    RefSeqiXP_006723058.1. XM_006722995.1.
    UniGeneiHs.207426.

    Genome annotation databases

    EnsembliENST00000600059; ENSP00000472020; ENSG00000142235.
    GeneIDi114783.
    KEGGihsa:114783.
    UCSCiuc002pjk.3. human.

    Polymorphism databases

    DMDMi117949603.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB067470 mRNA. Translation: BAB67776.1 . Different initiation.
    AC008403 Genomic DNA. No translation available.
    BC036690 mRNA. Translation: AAH36690.1 . Frameshift.
    RefSeqi XP_006723058.1. XM_006722995.1.
    UniGenei Hs.207426.

    3D structure databases

    ProteinModelPortali Q96Q04.
    SMRi Q96Q04. Positions 79-405.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q96Q04. 2 interactions.
    MINTi MINT-1391188.

    PTM databases

    PhosphoSitei Q96Q04.

    Polymorphism databases

    DMDMi 117949603.

    Proteomic databases

    PaxDbi Q96Q04.
    PRIDEi Q96Q04.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000600059 ; ENSP00000472020 ; ENSG00000142235 .
    GeneIDi 114783.
    KEGGi hsa:114783.
    UCSCi uc002pjk.3. human.

    Organism-specific databases

    CTDi 114783.
    GeneCardsi GC19M048988.
    H-InvDB HIX0015294.
    HGNCi HGNC:19295. LMTK3.
    HPAi HPA040203.
    neXtProti NX_Q96Q04.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000170369.
    HOVERGENi HBG081921.
    InParanoidi Q96Q04.
    KOi K08899.
    OrthoDBi EOG708VZ8.
    PhylomeDBi Q96Q04.
    TreeFami TF332280.

    Miscellaneous databases

    PROi Q96Q04.

    Gene expression databases

    Bgeei Q96Q04.
    CleanExi HS_LMTK3.
    Genevestigatori Q96Q04.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008266. Tyr_kinase_AS.
    [Graphical view ]
    Pfami PF07714. Pkinase_Tyr. 1 hit.
    [Graphical view ]
    PRINTSi PR00109. TYRKINASE.
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins."
      Nagase T., Kikuno R., Ohara O.
      DNA Res. 8:179-187(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    2. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 774-1460.
      Tissue: Brain.

    Entry informationi

    Entry nameiLMTK3_HUMAN
    AccessioniPrimary (citable) accession number: Q96Q04
    Secondary accession number(s): Q4G0U1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: October 31, 2006
    Last modified: October 1, 2014
    This is version 97 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3