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Q96Q04 (LMTK3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein kinase LMTK3

EC=2.7.11.1
Alternative name(s):
Lemur tyrosine kinase 3
Gene names
Name:LMTK3
Synonyms:KIAA1883, TYKLM3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1460 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Subcellular location

Membrane; Single-pass membrane protein Potential.

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family.

Contains 1 protein kinase domain.

Sequence caution

The sequence AAH36690.1 differs from that shown. Reason: Frameshift at position 809.

The sequence BAB67776.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 14601440Serine/threonine-protein kinase LMTK3
PRO_0000259460

Regions

Transmembrane40 – 6021Helical; Potential
Domain133 – 411279Protein kinase
Nucleotide binding139 – 1479ATP By similarity
Compositional bias416 – 14571042Pro-rich

Sites

Active site2661Proton acceptor By similarity
Binding site1641ATP By similarity

Amino acid modifications

Glycosylation10811N-linked (GlcNAc...) Potential
Glycosylation14051N-linked (GlcNAc...) Potential

Natural variations

Natural variant9001V → L.
Corresponds to variant rs1643478 [ dbSNP | Ensembl ].
VAR_057116
Natural variant9291L → V.
Corresponds to variant rs1643478 [ dbSNP | Ensembl ].
VAR_028943

Experimental info

Sequence conflict7741S → A in AAH36690. Ref.3
Sequence conflict13981P → R in AAH36690. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q96Q04 [UniParc].

Last modified October 31, 2006. Version 2.
Checksum: FF99FBFD873C73D3

FASTA1,460153,661
        10         20         30         40         50         60 
MPAPGALILL AAVSASGCLA SPAHPDGFAL GRAPLAPPYA VVLISCSGLL AFIFLLLTCL 

        70         80         90        100        110        120 
CCKRGDVGFK EFENPEGEDC SGEYTPPAEE TSSSQSLPDV YILPLAEVSL PMPAPQPSHS 

       130        140        150        160        170        180 
DMTTPLGLSR QHLSYLQEIG SGWFGKVILG EIFSDYTPAQ VVVKELRASA GPLEQRKFIS 

       190        200        210        220        230        240 
EAQPYRSLQH PNVLQCLGLC VETLPFLLIM EFCQLGDLKR YLRAQRPPEG LSPELPPRDL 

       250        260        270        280        290        300 
RTLQRMGLEI ARGLAHLHSH NYVHSDLALR NCLLTSDLTV RIGDYGLAHS NYKEDYYLTP 

       310        320        330        340        350        360 
ERLWIPLRWA APELLGELHG TFMVVDQSRE SNIWSLGVTL WELFEFGAQP YRHLSDEEVL 

       370        380        390        400        410        420 
AFVVRQQHVK LARPRLKLPY ADYWYDILQS CWRPPAQRPS ASDLQLQLTY LLSERPPRPP 

       430        440        450        460        470        480 
PPPPPPRDGP FPWPWPPAHS APRPGTLSSP FPLLDGFPGA DPDDVLTVTE SSRGLNLECL 

       490        500        510        520        530        540 
WEKARRGAGR GGGAPAWQPA SAPPAPHANP SNPFYEALST PSVLPVISAR SPSVSSEYYI 

       550        560        570        580        590        600 
RLEEHGSPPE PLFPNDWDPL DPGVPAPQAP QAPSEVPQLV SETWASPLFP APRPFPAQSS 

       610        620        630        640        650        660 
ASGSFLLSGW DPEGRGAGET LAGDPAEVLG ERGTAPWVEE EEEEEEGSSP GEDSSSLGGG 

       670        680        690        700        710        720 
PSRRGPLPCP LCSREGACSC LPLERGDAVA GWGGHPALGC PHPPEDDSSL RAERGSLADL 

       730        740        750        760        770        780 
PMAPPASAPP EFLDPLMGAA APQYPGRGPP PAPPPPPPPP RAPADPAASP DPPSAVASPG 

       790        800        810        820        830        840 
SGLSSPGPKP GDSGYETETP FSPEGAFPGG GAAEEEGVPR PRAPPEPPDP GAPRPPPDPG 

       850        860        870        880        890        900 
PLPLPGPREK PTFVVQVSTE QLLMSLREDV TRNLLGEKGA TARETGPRKA GRGPGNREKV 

       910        920        930        940        950        960 
PGLNRDPTVL GNGKQAPSLS LPVNGVTVLE NGDQRAPGIE EKAAENGALG SPEREEKVLE 

       970        980        990       1000       1010       1020 
NGELTPPRRE EKALENGELR SPEAGEKVLV NGGLTPPKSE DKVSENGGLR FPRNTERPPE 

      1030       1040       1050       1060       1070       1080 
TGPWRAPGPW EKTPESWGPA PTIGEPAPET SLERAPAPSA VVSSRNGGET APGPLGPAPK 

      1090       1100       1110       1120       1130       1140 
NGTLEPGTER RAPETGGAPR APGAGRLDLG SGGRAPVGTG TAPGGGPGSG VDAKAGWVDN 

      1150       1160       1170       1180       1190       1200 
TRPQPPPPPL PPPPEAQPRR LEPAPPRARP EVAPEGEPGA PDSRAGGDTA LSGDGDPPKP 

      1210       1220       1230       1240       1250       1260 
ERKGPEMPRL FLDLGPPQGN SEQIKARLSR LSLALPPLTL TPFPGPGPRR PPWEGADAGA 

      1270       1280       1290       1300       1310       1320 
AGGEAGGAGA PGPAEEDGED EDEDEEEDEE AAAPGAAAGP RGPGRARAAP VPVVVSSADA 

      1330       1340       1350       1360       1370       1380 
DAARPLRGLL KSPRGADEPE DSELERKRKM VSFHGDVTVY LFDQETPTNE LSVQAPPEGD 

      1390       1400       1410       1420       1430       1440 
TDPSTPPAPP TPPHPATPGD GFPSNDSGFG GSFEWAEDFP LLPPPGPPLC FSRFSVSPAL 

      1450       1460 
ETPGPPARAP DARPAGPVEN 

« Hide

References

[1]"Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins."
Nagase T., Kikuno R., Ohara O.
DNA Res. 8:179-187(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[2]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 774-1460.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB067470 mRNA. Translation: BAB67776.1. Different initiation.
AC008403 Genomic DNA. No translation available.
BC036690 mRNA. Translation: AAH36690.1. Frameshift.
RefSeqXP_006723058.1. XM_006722995.1.
UniGeneHs.207426.

3D structure databases

ProteinModelPortalQ96Q04.
SMRQ96Q04. Positions 79-405.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ96Q04. 2 interactions.
MINTMINT-1391188.

PTM databases

PhosphoSiteQ96Q04.

Polymorphism databases

DMDM117949603.

Proteomic databases

PaxDbQ96Q04.
PRIDEQ96Q04.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000600059; ENSP00000472020; ENSG00000142235.
GeneID114783.
UCSCuc002pjk.3. human.

Organism-specific databases

GeneCardsGC19M048988.
H-InvDBHIX0015294.
HGNCHGNC:19295. LMTK3.
HPAHPA040203.
neXtProtNX_Q96Q04.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000170369.
HOVERGENHBG081921.
InParanoidQ96Q04.
OrthoDBEOG708VZ8.
PhylomeDBQ96Q04.
TreeFamTF332280.

Gene expression databases

BgeeQ96Q04.
CleanExHS_LMTK3.
GenevestigatorQ96Q04.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
[Graphical view]
PfamPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSPR00109. TYRKINASE.
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ96Q04.

Entry information

Entry nameLMTK3_HUMAN
AccessionPrimary (citable) accession number: Q96Q04
Secondary accession number(s): Q4G0U1
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: May 14, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM