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Protein

Pseudouridylate synthase 7 homolog

Gene

PUS7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

tRNA uridine = tRNA pseudouridine.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei294NucleophileBy similarity1

GO - Molecular functioni

  • enzyme binding Source: UniProtKB
  • pseudouridine synthase activity Source: GO_Central
  • RNA binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processtRNA processing

Enzyme and pathway databases

ReactomeiR-HSA-6782315. tRNA modification in the nucleus and cytosol.

Names & Taxonomyi

Protein namesi
Recommended name:
Pseudouridylate synthase 7 homolog (EC:5.4.99.-)
Gene namesi
Name:PUS7
Synonyms:KIAA1897
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:26033. PUS7.

Subcellular locationi

GO - Cellular componenti

Pathology & Biotechi

Organism-specific databases

DisGeNETi54517.
OpenTargetsiENSG00000091127.
PharmGKBiPA143485587.

Polymorphism and mutation databases

BioMutaiPUS7.
DMDMi37090412.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001525581 – 661Pseudouridylate synthase 7 homologAdd BLAST661

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei10PhosphoserineCombined sources1
Modified residuei127PhosphoserineCombined sources1
Modified residuei610PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ96PZ0.
MaxQBiQ96PZ0.
PaxDbiQ96PZ0.
PeptideAtlasiQ96PZ0.
PRIDEiQ96PZ0.

PTM databases

iPTMnetiQ96PZ0.
PhosphoSitePlusiQ96PZ0.

Expressioni

Gene expression databases

BgeeiENSG00000091127.
CleanExiHS_PUS7.
ExpressionAtlasiQ96PZ0. baseline and differential.
GenevisibleiQ96PZ0. HS.

Organism-specific databases

HPAiHPA024116.

Interactioni

GO - Molecular functioni

  • enzyme binding Source: UniProtKB

Protein-protein interaction databases

BioGridi120011. 42 interactors.
IntActiQ96PZ0. 1 interactor.
STRINGi9606.ENSP00000348722.

Structurei

Secondary structure

1661
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi112 – 114Combined sources3
Beta strandi129 – 133Combined sources5
Helixi134 – 136Combined sources3
Beta strandi137 – 142Combined sources6
Helixi166 – 177Combined sources12
Beta strandi192 – 195Combined sources4
Helixi201 – 213Combined sources13
Beta strandi219 – 225Combined sources7
Beta strandi228 – 234Combined sources7
Beta strandi256 – 266Combined sources11
Helixi269 – 280Combined sources12
Helixi284 – 286Combined sources3
Beta strandi287 – 290Combined sources4
Beta strandi295 – 306Combined sources12
Helixi310 – 315Combined sources6
Helixi316 – 319Combined sources4
Beta strandi321 – 333Combined sources13
Beta strandi342 – 351Combined sources10
Helixi356 – 368Combined sources13
Helixi377 – 380Combined sources4
Helixi387 – 395Combined sources9
Helixi399 – 407Combined sources9
Helixi416 – 428Combined sources13
Helixi431 – 435Combined sources5
Beta strandi441 – 443Combined sources3
Helixi444 – 455Combined sources12
Helixi460 – 464Combined sources5
Helixi469 – 495Combined sources27
Beta strandi504 – 507Combined sources4
Beta strandi510 – 513Combined sources4
Beta strandi516 – 518Combined sources3
Helixi519 – 521Combined sources3
Helixi524 – 526Combined sources3
Beta strandi527 – 531Combined sources5
Beta strandi533 – 535Combined sources3
Helixi543 – 553Combined sources11
Helixi566 – 568Combined sources3
Beta strandi573 – 579Combined sources7
Beta strandi582 – 592Combined sources11
Helixi602 – 607Combined sources6
Beta strandi619 – 629Combined sources11
Helixi635 – 643Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5KKPX-ray2.26A99-661[»]
ProteinModelPortaliQ96PZ0.
SMRiQ96PZ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini370 – 580TRUDPROSITE-ProRule annotationAdd BLAST211

Sequence similaritiesi

Belongs to the pseudouridine synthase TruD family.Curated

Phylogenomic databases

eggNOGiKOG2339. Eukaryota.
COG0585. LUCA.
GeneTreeiENSGT00530000063554.
HOGENOMiHOG000203484.
HOVERGENiHBG056990.
InParanoidiQ96PZ0.
KOiK06176.
OMAiNFSYKNH.
OrthoDBiEOG091G062Z.
PhylomeDBiQ96PZ0.
TreeFamiTF314278.

Family and domain databases

InterProiView protein in InterPro
IPR020103. PsdUridine_synth_cat_dom.
IPR001656. PsdUridine_synth_TruD.
IPR020119. PsdUridine_synth_TruD_CS.
IPR011760. PsdUridine_synth_TruD_insert.
PANTHERiPTHR13326. PTHR13326. 1 hit.
PfamiView protein in Pfam
PF01142. TruD. 1 hit.
SUPFAMiSSF55120. SSF55120. 4 hits.
TIGRFAMsiTIGR00094. tRNA_TruD_broad. 1 hit.
PROSITEiView protein in PROSITE
PS50984. TRUD. 1 hit.
PS01268. UPF0024. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96PZ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEMTEMTGVS LKRGALVVED NDSGVPVEET KKQKLSECSL TKGQDGLQND
60 70 80 90 100
FLSISEDVPR PPDTVSTGKG GKNSEAQLED EEEEEEDGLS EECEEEESES
110 120 130 140 150
FADMMKHGLT EADVGITKFV SSHQGFSGIL KERYSDFVVH EIGKDGRISH
160 170 180 190 200
LNDLSIPVDE EDPSEDIFTV LTAEEKQRLE ELQLFKNKET SVAIEVIEDT
210 220 230 240 250
KEKRTIIHQA IKSLFPGLET KTEDREGKKY IVAYHAAGKK ALANPRKHSW
260 270 280 290 300
PKSRGSYCHF VLYKENKDTM DAINVLSKYL RVKPNIFSYM GTKDKRAITV
310 320 330 340 350
QEIAVLKITA QRLAHLNKCL MNFKLGNFSY QKNPLKLGEL QGNHFTVVLR
360 370 380 390 400
NITGTDDQVQ QAMNSLKEIG FINYYGMQRF GTTAVPTYQV GRAILQNSWT
410 420 430 440 450
EVMDLILKPR SGAEKGYLVK CREEWAKTKD PTAALRKLPV KRCVEGQLLR
460 470 480 490 500
GLSKYGMKNI VSAFGIIPRN NRLMYIHSYQ SYVWNNMVSK RIEDYGLKPV
510 520 530 540 550
PGDLVLKGAT ATYIEEDDVN NYSIHDVVMP LPGFDVIYPK HKIQEAYREM
560 570 580 590 600
LTADNLDIDN MRHKIRDYSL SGAYRKIIIR PQNVSWEVVA YDDPKIPLFN
610 620 630 640 650
TDVDNLEGKT PPVFASEGKY RALKMDFSLP PSTYATMAIR EVLKMDTSIK
660
NQTQLNTTWL R
Length:661
Mass (Da):75,035
Last modified:September 26, 2003 - v2
Checksum:i6F6A05A9B57B1560
GO

Sequence cautioni

The sequence BAA91203 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti244N → KVRTAAD (PubMed:11572484).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC073138 Genomic DNA. Translation: AAS07447.1.
AC074013 Genomic DNA. No translation available.
BC005209 mRNA. Translation: AAH05209.3.
BC011396 mRNA. Translation: AAH11396.2.
AB067484 mRNA. Translation: BAB67790.1.
AK000492 mRNA. Translation: BAA91203.1. Different initiation.
CCDSiCCDS34725.1.
RefSeqiNP_001305092.1. NM_001318163.1.
NP_001305093.1. NM_001318164.1.
NP_061915.2. NM_019042.4.
UniGeneiHs.520619.

Genome annotation databases

EnsembliENST00000356362; ENSP00000348722; ENSG00000091127.
ENST00000469408; ENSP00000417402; ENSG00000091127.
GeneIDi54517.
KEGGihsa:54517.
UCSCiuc003vcx.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC073138 Genomic DNA. Translation: AAS07447.1.
AC074013 Genomic DNA. No translation available.
BC005209 mRNA. Translation: AAH05209.3.
BC011396 mRNA. Translation: AAH11396.2.
AB067484 mRNA. Translation: BAB67790.1.
AK000492 mRNA. Translation: BAA91203.1. Different initiation.
CCDSiCCDS34725.1.
RefSeqiNP_001305092.1. NM_001318163.1.
NP_001305093.1. NM_001318164.1.
NP_061915.2. NM_019042.4.
UniGeneiHs.520619.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5KKPX-ray2.26A99-661[»]
ProteinModelPortaliQ96PZ0.
SMRiQ96PZ0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120011. 42 interactors.
IntActiQ96PZ0. 1 interactor.
STRINGi9606.ENSP00000348722.

PTM databases

iPTMnetiQ96PZ0.
PhosphoSitePlusiQ96PZ0.

Polymorphism and mutation databases

BioMutaiPUS7.
DMDMi37090412.

Proteomic databases

EPDiQ96PZ0.
MaxQBiQ96PZ0.
PaxDbiQ96PZ0.
PeptideAtlasiQ96PZ0.
PRIDEiQ96PZ0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356362; ENSP00000348722; ENSG00000091127.
ENST00000469408; ENSP00000417402; ENSG00000091127.
GeneIDi54517.
KEGGihsa:54517.
UCSCiuc003vcx.5. human.

Organism-specific databases

CTDi54517.
DisGeNETi54517.
GeneCardsiPUS7.
HGNCiHGNC:26033. PUS7.
HPAiHPA024116.
MIMi616261. gene.
neXtProtiNX_Q96PZ0.
OpenTargetsiENSG00000091127.
PharmGKBiPA143485587.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2339. Eukaryota.
COG0585. LUCA.
GeneTreeiENSGT00530000063554.
HOGENOMiHOG000203484.
HOVERGENiHBG056990.
InParanoidiQ96PZ0.
KOiK06176.
OMAiNFSYKNH.
OrthoDBiEOG091G062Z.
PhylomeDBiQ96PZ0.
TreeFamiTF314278.

Enzyme and pathway databases

ReactomeiR-HSA-6782315. tRNA modification in the nucleus and cytosol.

Miscellaneous databases

GenomeRNAii54517.
PROiQ96PZ0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000091127.
CleanExiHS_PUS7.
ExpressionAtlasiQ96PZ0. baseline and differential.
GenevisibleiQ96PZ0. HS.

Family and domain databases

InterProiView protein in InterPro
IPR020103. PsdUridine_synth_cat_dom.
IPR001656. PsdUridine_synth_TruD.
IPR020119. PsdUridine_synth_TruD_CS.
IPR011760. PsdUridine_synth_TruD_insert.
PANTHERiPTHR13326. PTHR13326. 1 hit.
PfamiView protein in Pfam
PF01142. TruD. 1 hit.
SUPFAMiSSF55120. SSF55120. 4 hits.
TIGRFAMsiTIGR00094. tRNA_TruD_broad. 1 hit.
PROSITEiView protein in PROSITE
PS50984. TRUD. 1 hit.
PS01268. UPF0024. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPUS7_HUMAN
AccessioniPrimary (citable) accession number: Q96PZ0
Secondary accession number(s): Q75MG4, Q9NX19
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: September 26, 2003
Last modified: March 15, 2017
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.