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Q96PY6

- NEK1_HUMAN

UniProt

Q96PY6 - NEK1_HUMAN

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Protein

Serine/threonine-protein kinase Nek1

Gene

NEK1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity. Implicated in the control of meiosis (By similarity). Involved in cilium assembly. In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death.By similarity2 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Magnesium.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei33 – 331ATPPROSITE-ProRule annotation
Active sitei128 – 1281Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 189ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. protein kinase activity Source: MGI
  4. protein serine/threonine kinase activity Source: UniProtKB-KW
  5. protein tyrosine kinase activity Source: UniProtKB-KW

GO - Biological processi

  1. cellular response to DNA damage stimulus Source: Ensembl
  2. cilium assembly Source: UniProtKB
  3. mitotic nuclear division Source: UniProtKB-KW
  4. response to ionizing radiation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase

Keywords - Biological processi

Cell cycle, Cell division, Cilium biogenesis/degradation, Mitosis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ96PY6.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase Nek1 (EC:2.7.11.1)
Alternative name(s):
Never in mitosis A-related kinase 1
Short name:
NimA-related protein kinase 1
Renal carcinoma antigen NY-REN-55
Gene namesi
Name:NEK1
Synonyms:KIAA1901
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:7744. NEK1.

Subcellular locationi

Nucleus 1 Publication. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity
Note: Associated with the pericentriolar material. Localizes to centrosome during interphase and mitosis (By similarity).By similarity

GO - Cellular componenti

  1. centrosome Source: UniProtKB
  2. cytoplasm Source: MGI
  3. nucleus Source: MGI
  4. pericentriolar material Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Involvement in diseasei

Short-rib thoracic dysplasia 6 with or without polydactyly (SRTD6) [MIM:263520]: A form of short-rib thoracic dysplasia, a group of autosomal recessive ciliopathies that are characterized by a constricted thoracic cage, short ribs, shortened tubular bones, and a 'trident' appearance of the acetabular roof. Polydactyly is variably present. Non-skeletal involvement can include cleft lip/palate as well as anomalies of major organs such as the brain, eye, heart, kidneys, liver, pancreas, intestines, and genitalia. Some forms of the disease are lethal in the neonatal period due to respiratory insufficiency secondary to a severely restricted thoracic cage, whereas others are compatible with life. Disease spectrum encompasses Ellis-van Creveld syndrome, asphyxiating thoracic dystrophy (Jeune syndrome), Mainzer-Saldino syndrome, and short rib-polydactyly syndrome.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry. In some cases NEK1 mutations result in disease phenotype in the presence of mutations in DYNC2H1 indicating digenic inheritance (digenic short rib-polydactyly syndrome 3/6 with polydactyly) (PubMed:21211617).1 Publication
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti145 – 1451G → R in SRTD6. 1 Publication
VAR_069617
Natural varianti253 – 2531L → S in SRTD6. 1 Publication
VAR_069618

Keywords - Diseasei

Ciliopathy

Organism-specific databases

MIMi263520. phenotype.
Orphaneti93269. Short rib-polydactyly syndrome, Majewski type.
PharmGKBiPA31545.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12581258Serine/threonine-protein kinase Nek1PRO_0000086418Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei162 – 1621Phosphothreonine; by autocatalysisBy similarity
Modified residuei414 – 4141Phosphoserine1 Publication
Modified residuei418 – 4181Phosphoserine1 Publication
Modified residuei428 – 4281Phosphoserine1 Publication
Modified residuei653 – 6531Phosphoserine1 Publication
Modified residuei798 – 7981Phosphoserine1 Publication
Modified residuei834 – 8341Phosphoserine1 Publication
Modified residuei868 – 8681Phosphoserine1 Publication
Modified residuei881 – 8811Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ96PY6.
PaxDbiQ96PY6.
PRIDEiQ96PY6.

PTM databases

PhosphoSiteiQ96PY6.

Expressioni

Tissue specificityi

High fetal expression in the brain and kidney.1 Publication

Gene expression databases

BgeeiQ96PY6.
CleanExiHS_NEK1.
ExpressionAtlasiQ96PY6. baseline and differential.
GenevestigatoriQ96PY6.

Organism-specific databases

HPAiHPA020873.
HPA040413.

Interactioni

Subunit structurei

Binds to SPERT.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
FEZ1Q996892EBI-373615,EBI-396435
FEZ2Q9UHY82EBI-373615,EBI-396453
LRRK2Q5S0072EBI-373615,EBI-5323863

Protein-protein interaction databases

BioGridi110825. 18 interactions.
IntActiQ96PY6. 16 interactions.
STRINGi9606.ENSP00000408020.

Structurei

Secondary structure

1
1258
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 96
Beta strandi18 – 236
Turni24 – 263
Beta strandi29 – 368
Helixi42 – 5716
Beta strandi66 – 727
Beta strandi75 – 817
Helixi88 – 947
Turni95 – 973
Helixi102 – 12120
Helixi131 – 1333
Beta strandi134 – 1363
Beta strandi142 – 1443
Beta strandi149 – 1513
Helixi155 – 16410
Helixi172 – 1754
Helixi182 – 19817
Helixi208 – 21710
Helixi229 – 23810
Helixi243 – 2453
Helixi249 – 2535
Helixi256 – 2594
Helixi260 – 2645
Helixi268 – 2758

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4APCX-ray2.10A/B1-328[»]
4B9DX-ray1.90A/B1-328[»]
ProteinModelPortaliQ96PY6.
SMRiQ96PY6. Positions 1-315.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 258255Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000118997.
HOVERGENiHBG006460.
InParanoidiQ96PY6.
KOiK08857.
OMAiIAEEFCL.
OrthoDBiEOG7D59P5.
PhylomeDBiQ96PY6.
TreeFamiTF333575.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96PY6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEKYVRLQKI GEGSFGKAIL VKSTEDGRQY VIKEINISRM SSKEREESRR
60 70 80 90 100
EVAVLANMKH PNIVQYRESF EENGSLYIVM DYCEGGDLFK RINAQKGVLF
110 120 130 140 150
QEDQILDWFV QICLALKHVH DRKILHRDIK SQNIFLTKDG TVQLGDFGIA
160 170 180 190 200
RVLNSTVELA RTCIGTPYYL SPEICENKPY NNKSDIWALG CVLYELCTLK
210 220 230 240 250
HAFEAGSMKN LVLKIISGSF PPVSLHYSYD LRSLVSQLFK RNPRDRPSVN
260 270 280 290 300
SILEKGFIAK RIEKFLSPQL IAEEFCLKTF SKFGSQPIPA KRPASGQNSI
310 320 330 340 350
SVMPAQKITK PAAKYGIPLA YKKYGDKKLH EKKPLQKHKQ AHQTPEKRVN
360 370 380 390 400
TGEERRKISE EAARKRRLEF IEKEKKQKDQ IISLMKAEQM KRQEKERLER
410 420 430 440 450
INRAREQGWR NVLSAGGSGE VKAPFLGSGG TIAPSSFSSR GQYEHYHAIF
460 470 480 490 500
DQMQQQRAED NEAKWKREIY GRGLPERGIL PGVRPGFPYG AAGHHHFPDA
510 520 530 540 550
DDIRKTLKRL KAVSKQANAN RQKGQLAVER AKQVEEFLQR KREAMQNKAR
560 570 580 590 600
AEGHMVYLAR LRQIRLQNFN ERQQIKAKLR GEKKEANHSE GQEGSEEADM
610 620 630 640 650
RRKKIESLKA HANARAAVLK EQLERKRKEA YEREKKVWEE HLVAKGVKSS
660 670 680 690 700
DVSPPLGQHE TGGSPSKQQM RSVISVTSAL KEVGVDSSLT DTRETSEEMQ
710 720 730 740 750
KTNNAISSKR EILRRLNENL KAQEDEKGKQ NLSDTFEINV HEDAKEHEKE
760 770 780 790 800
KSVSSDRKKW EAGGQLVIPL DELTLDTSFS TTERHTVGEV IKLGPNGSPR
810 820 830 840 850
RAWGKSPTDS VLKILGEAEL QLQTELLENT TIRSEISPEG EKYKPLITGE
860 870 880 890 900
KKVQCISHEI NPSAIVDSPV ETKSPEFSEA SPQMSLKLEG NLEEPDDLET
910 920 930 940 950
EILQEPSGTN KDESLPCTIT DVWISEEKET KETQSADRIT IQENEVSEDG
960 970 980 990 1000
VSSTVDQLSD IHIEPGTNDS QHSKCDVDKS VQPEPFFHKV VHSEHLNLVP
1010 1020 1030 1040 1050
QVQSVQCSPE ESFAFRSHSH LPPKNKNKNS LLIGLSTGLF DANNPKMLRT
1060 1070 1080 1090 1100
CSLPDLSKLF RTLMDVPTVG DVRQDNLEID EIEDENIKEG PSDSEDIVFE
1110 1120 1130 1140 1150
ETDTDLQELQ ASMEQLLREQ PGEEYSEEEE SVLKNSDVEP TANGTDVADE
1160 1170 1180 1190 1200
DDNPSSESAL NEEWHSDNSD GEIASECECD SVFNHLEELR LHLEQEMGFE
1210 1220 1230 1240 1250
KFFEVYEKIK AIHEDEDENI EICSKIVQNI LGNEHQHLYA KILHLVMADG

AYQEDNDE
Length:1,258
Mass (Da):142,828
Last modified:August 13, 2002 - v2
Checksum:i339C4BFA56612530
GO
Isoform 2 (identifier: Q96PY6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     478-521: Missing.

Note: No experimental confirmation available.

Show »
Length:1,214
Mass (Da):138,068
Checksum:i347246AED3D9FD79
GO
Isoform 3 (identifier: Q96PY6-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     555-555: M → MGILQNLAAMYGGRPSSSRGGKPRNKEEE

Note: No experimental confirmation available.

Show »
Length:1,286
Mass (Da):145,814
Checksum:iF94B3F9C0666059D
GO
Isoform 4 (identifier: Q96PY6-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     398-422: Missing.
     477-520: Missing.

Note: No experimental confirmation available.

Show »
Length:1,189
Mass (Da):135,303
Checksum:iCAE13631DC2A2151
GO
Isoform 5 (identifier: Q96PY6-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     522-527: QKGQLA → LDCDDP
     528-1258: Missing.

Note: No experimental confirmation available.

Show »
Length:527
Mass (Da):60,250
Checksum:i47E0707A533EE57C
GO
Isoform 6 (identifier: Q96PY6-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     477-520: Missing.
     555-555: M → MGILQNLAAMYGGRPSSSRGGKPRNKEEE

Note: No experimental confirmation available.

Show »
Length:1,242
Mass (Da):141,053
Checksum:i5CB4B464CF15573C
GO

Sequence cautioni

The sequence AAH15147.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
The sequence BAB15207.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAB55209.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAB67794.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti250 – 2501N → D in CAI45943. (PubMed:17974005)Curated
Sequence conflicti602 – 6021R → RK in CAI45943. (PubMed:17974005)Curated
Sequence conflicti1232 – 12321G → E in AAD42879. (PubMed:10508479)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti10 – 101I → F.1 Publication
Corresponds to variant rs34214559 [ dbSNP | Ensembl ].
VAR_040900
Natural varianti25 – 251E → K in a lung large cell carcinoma sample; somatic mutation. 1 Publication
VAR_040901
Natural varianti76 – 761L → V.1 Publication
Corresponds to variant rs35093214 [ dbSNP | Ensembl ].
VAR_040902
Natural varianti145 – 1451G → R in SRTD6. 1 Publication
VAR_069617
Natural varianti253 – 2531L → S in SRTD6. 1 Publication
VAR_069618
Natural varianti294 – 2941A → P in a lung adenocarcinoma sample; somatic mutation. 1 Publication
VAR_040903
Natural varianti355 – 3551R → G.1 Publication
Corresponds to variant rs35763578 [ dbSNP | Ensembl ].
VAR_040904
Natural varianti463 – 4631A → V.1 Publication
Corresponds to variant rs34540355 [ dbSNP | Ensembl ].
VAR_040905
Natural varianti598 – 5981A → T.1 Publication
Corresponds to variant rs33933790 [ dbSNP | Ensembl ].
VAR_046486
Natural varianti717 – 7171N → K.
Corresponds to variant rs34324114 [ dbSNP | Ensembl ].
VAR_061743
Natural varianti724 – 7241E → G.2 Publications
Corresponds to variant rs34099167 [ dbSNP | Ensembl ].
VAR_051651
Natural varianti745 – 7451K → N.1 Publication
VAR_040906
Natural varianti883 – 8831Q → E.1 Publication
Corresponds to variant rs6828134 [ dbSNP | Ensembl ].
VAR_046488
Natural varianti1180 – 11801D → N.1 Publication
Corresponds to variant rs35503975 [ dbSNP | Ensembl ].
VAR_046489

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei398 – 42225Missing in isoform 4. 1 PublicationVSP_035435Add
BLAST
Alternative sequencei477 – 52044Missing in isoform 4 and isoform 6. 1 PublicationVSP_035436Add
BLAST
Alternative sequencei478 – 52144Missing in isoform 2. 1 PublicationVSP_004870Add
BLAST
Alternative sequencei522 – 5276QKGQLA → LDCDDP in isoform 5. 1 PublicationVSP_035437
Alternative sequencei528 – 1258731Missing in isoform 5. 1 PublicationVSP_035438Add
BLAST
Alternative sequencei555 – 5551M → MGILQNLAAMYGGRPSSSRG GKPRNKEEE in isoform 3 and isoform 6. 1 PublicationVSP_035439

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB067488 mRNA. Translation: BAB67794.1. Different initiation.
CR933642 mRNA. Translation: CAI45943.1.
AC116615 Genomic DNA. No translation available.
AC116621 Genomic DNA. No translation available.
AC084724 Genomic DNA. No translation available.
CH471056 Genomic DNA. Translation: EAX04791.1.
BC015147 mRNA. Translation: AAH15147.1. Sequence problems.
BC037790 mRNA. Translation: AAH37790.1.
BC114491 mRNA. Translation: AAI14492.1.
AK025658 mRNA. Translation: BAB15207.1. Different initiation.
AK027580 mRNA. Translation: BAB55209.1. Different initiation.
AF155113 mRNA. Translation: AAD42879.1.
CCDSiCCDS47162.1. [Q96PY6-1]
CCDS56348.1. [Q96PY6-4]
CCDS56349.1. [Q96PY6-2]
CCDS56350.1. [Q96PY6-6]
CCDS56351.1. [Q96PY6-3]
RefSeqiNP_001186326.1. NM_001199397.1. [Q96PY6-3]
NP_001186327.1. NM_001199398.1. [Q96PY6-6]
NP_001186328.1. NM_001199399.1. [Q96PY6-4]
NP_001186329.1. NM_001199400.1. [Q96PY6-2]
NP_036356.1. NM_012224.2. [Q96PY6-1]
UniGeneiHs.481181.

Genome annotation databases

EnsembliENST00000439128; ENSP00000408020; ENSG00000137601. [Q96PY6-1]
ENST00000507142; ENSP00000424757; ENSG00000137601. [Q96PY6-3]
ENST00000510533; ENSP00000427653; ENSG00000137601. [Q96PY6-2]
ENST00000511633; ENSP00000423332; ENSG00000137601. [Q96PY6-6]
ENST00000512193; ENSP00000424938; ENSG00000137601. [Q96PY6-4]
GeneIDi4750.
KEGGihsa:4750.
UCSCiuc003isb.2. human. [Q96PY6-1]
uc003isc.2. human. [Q96PY6-2]
uc003isd.2. human. [Q96PY6-3]
uc003ise.2. human.
uc003isf.2. human. [Q96PY6-4]
uc003isg.1. human. [Q96PY6-5]

Polymorphism databases

DMDMi22256934.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB067488 mRNA. Translation: BAB67794.1 . Different initiation.
CR933642 mRNA. Translation: CAI45943.1 .
AC116615 Genomic DNA. No translation available.
AC116621 Genomic DNA. No translation available.
AC084724 Genomic DNA. No translation available.
CH471056 Genomic DNA. Translation: EAX04791.1 .
BC015147 mRNA. Translation: AAH15147.1 . Sequence problems.
BC037790 mRNA. Translation: AAH37790.1 .
BC114491 mRNA. Translation: AAI14492.1 .
AK025658 mRNA. Translation: BAB15207.1 . Different initiation.
AK027580 mRNA. Translation: BAB55209.1 . Different initiation.
AF155113 mRNA. Translation: AAD42879.1 .
CCDSi CCDS47162.1. [Q96PY6-1 ]
CCDS56348.1. [Q96PY6-4 ]
CCDS56349.1. [Q96PY6-2 ]
CCDS56350.1. [Q96PY6-6 ]
CCDS56351.1. [Q96PY6-3 ]
RefSeqi NP_001186326.1. NM_001199397.1. [Q96PY6-3 ]
NP_001186327.1. NM_001199398.1. [Q96PY6-6 ]
NP_001186328.1. NM_001199399.1. [Q96PY6-4 ]
NP_001186329.1. NM_001199400.1. [Q96PY6-2 ]
NP_036356.1. NM_012224.2. [Q96PY6-1 ]
UniGenei Hs.481181.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4APC X-ray 2.10 A/B 1-328 [» ]
4B9D X-ray 1.90 A/B 1-328 [» ]
ProteinModelPortali Q96PY6.
SMRi Q96PY6. Positions 1-315.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110825. 18 interactions.
IntActi Q96PY6. 16 interactions.
STRINGi 9606.ENSP00000408020.

Chemistry

BindingDBi Q96PY6.
ChEMBLi CHEMBL5855.
GuidetoPHARMACOLOGYi 2114.

PTM databases

PhosphoSitei Q96PY6.

Polymorphism databases

DMDMi 22256934.

Proteomic databases

MaxQBi Q96PY6.
PaxDbi Q96PY6.
PRIDEi Q96PY6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000439128 ; ENSP00000408020 ; ENSG00000137601 . [Q96PY6-1 ]
ENST00000507142 ; ENSP00000424757 ; ENSG00000137601 . [Q96PY6-3 ]
ENST00000510533 ; ENSP00000427653 ; ENSG00000137601 . [Q96PY6-2 ]
ENST00000511633 ; ENSP00000423332 ; ENSG00000137601 . [Q96PY6-6 ]
ENST00000512193 ; ENSP00000424938 ; ENSG00000137601 . [Q96PY6-4 ]
GeneIDi 4750.
KEGGi hsa:4750.
UCSCi uc003isb.2. human. [Q96PY6-1 ]
uc003isc.2. human. [Q96PY6-2 ]
uc003isd.2. human. [Q96PY6-3 ]
uc003ise.2. human.
uc003isf.2. human. [Q96PY6-4 ]
uc003isg.1. human. [Q96PY6-5 ]

Organism-specific databases

CTDi 4750.
GeneCardsi GC04M170314.
HGNCi HGNC:7744. NEK1.
HPAi HPA020873.
HPA040413.
MIMi 263520. phenotype.
604588. gene.
neXtProti NX_Q96PY6.
Orphaneti 93269. Short rib-polydactyly syndrome, Majewski type.
PharmGKBi PA31545.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00760000118997.
HOVERGENi HBG006460.
InParanoidi Q96PY6.
KOi K08857.
OMAi IAEEFCL.
OrthoDBi EOG7D59P5.
PhylomeDBi Q96PY6.
TreeFami TF333575.

Enzyme and pathway databases

SignaLinki Q96PY6.

Miscellaneous databases

GeneWikii NEK1.
GenomeRNAii 4750.
NextBioi 18306.
PROi Q96PY6.
SOURCEi Search...

Gene expression databases

Bgeei Q96PY6.
CleanExi HS_NEK1.
ExpressionAtlasi Q96PY6. baseline and differential.
Genevestigatori Q96PY6.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins."
    Nagase T., Kikuno R., Ohara O.
    DNA Res. 8:179-187(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT GLY-724.
    Tissue: Uterus.
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Bone marrow and Brain.
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 91-1258 (ISOFORM 5), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 865-1258.
  7. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 444-1258 (ISOFORM 2), IDENTIFICATION AS A RENAL CANCER ANTIGEN.
    Tissue: Renal cell carcinoma.
  8. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-414; SER-418; SER-428; SER-653; SER-798; SER-834; SER-868 AND SER-881, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Phosphorylation by Nek1 regulates opening and closing of voltage dependent anion channel 1."
    Chen Y., Gaczynska M., Osmulski P., Polci R., Riley D.J.
    Biochem. Biophys. Res. Commun. 394:798-803(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN PHOSPHORYLATION OF VDAC1.
  12. Cited for: FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INVOLVEMENT IN DIGENIC SHORT-RIB THORACIC DYSPLASIA 3/6 WITH POLYDACTYLY.
  13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] PHE-10; LYS-25; VAL-76; PRO-294; GLY-355; VAL-463; THR-598; GLY-724; ASN-745; GLU-883 AND ASN-1180.
  15. Cited for: VARIANTS SRTD6 ARG-145 AND SER-253.

Entry informationi

Entry nameiNEK1_HUMAN
AccessioniPrimary (citable) accession number: Q96PY6
Secondary accession number(s): G5E9Z3
, Q05DG5, Q14CB7, Q5H9T1, Q6PIB8, Q96SS2, Q9H6P7, Q9Y594
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 2002
Last sequence update: August 13, 2002
Last modified: October 29, 2014
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3