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Protein

Serine/threonine-protein kinase Nek1

Gene

NEK1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity. Implicated in the control of meiosis (By similarity). Involved in cilium assembly. In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death.By similarity2 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei33ATPPROSITE-ProRule annotation1
Active sitei128Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 18ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • kinase activity Source: CACAO
  • metal ion binding Source: UniProtKB-KW
  • protein kinase activity Source: MGI
  • protein tyrosine kinase activity Source: UniProtKB-KW
  • receptor signaling protein serine/threonine kinase activity Source: GO_Central

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • cilium assembly Source: UniProtKB
  • mitotic nuclear division Source: UniProtKB-KW
  • protein phosphorylation Source: CACAO
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase

Keywords - Biological processi

Cell cycle, Cell division, Cilium biogenesis/degradation, Mitosis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS06366-MONOMER.
SignaLinkiQ96PY6.
SIGNORiQ96PY6.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase Nek1 (EC:2.7.11.1)
Alternative name(s):
Never in mitosis A-related kinase 1
Short name:
NimA-related protein kinase 1
Renal carcinoma antigen NY-REN-55
Gene namesi
Name:NEK1
Synonyms:KIAA1901
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:7744. NEK1.

Subcellular locationi

GO - Cellular componenti

  • centrosome Source: UniProtKB
  • cytoplasm Source: MGI
  • nucleus Source: MGI
  • pericentriolar material Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Involvement in diseasei

Short-rib thoracic dysplasia 6 with or without polydactyly (SRTD6)1 Publication
The disease is caused by mutations affecting the gene represented in this entry. In some cases NEK1 mutations result in disease phenotype in the presence of mutations in DYNC2H1 indicating digenic inheritance (digenic short rib-polydactyly syndrome 3/6 with polydactyly) (PubMed:21211617).1 Publication
Disease descriptionA form of short-rib thoracic dysplasia, a group of autosomal recessive ciliopathies that are characterized by a constricted thoracic cage, short ribs, shortened tubular bones, and a 'trident' appearance of the acetabular roof. Polydactyly is variably present. Non-skeletal involvement can include cleft lip/palate as well as anomalies of major organs such as the brain, eye, heart, kidneys, liver, pancreas, intestines, and genitalia. Some forms of the disease are lethal in the neonatal period due to respiratory insufficiency secondary to a severely restricted thoracic cage, whereas others are compatible with life. Disease spectrum encompasses Ellis-van Creveld syndrome, asphyxiating thoracic dystrophy (Jeune syndrome), Mainzer-Saldino syndrome, and short rib-polydactyly syndrome.
See also OMIM:263520
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_069617145G → R in SRTD6. 1 PublicationCorresponds to variant rs431905508dbSNPEnsembl.1
Natural variantiVAR_069618253L → S in SRTD6. 1 Publication1

Keywords - Diseasei

Ciliopathy

Organism-specific databases

DisGeNETi4750.
MalaCardsiNEK1.
MIMi263520. phenotype.
OpenTargetsiENSG00000137601.
Orphaneti93269. Short rib-polydactyly syndrome, Majewski type.
PharmGKBiPA31545.

Chemistry databases

ChEMBLiCHEMBL5855.
GuidetoPHARMACOLOGYi2114.

Polymorphism and mutation databases

BioMutaiNEK1.
DMDMi22256934.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000864181 – 1258Serine/threonine-protein kinase Nek1Add BLAST1258

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei156PhosphothreonineCombined sources1
Modified residuei162Phosphothreonine; by autocatalysisBy similarity1
Modified residuei414PhosphoserineCombined sources1
Modified residuei418PhosphoserineCombined sources1
Modified residuei428PhosphoserineCombined sources1
Modified residuei438PhosphoserineBy similarity1
Modified residuei653PhosphoserineCombined sources1
Modified residuei661PhosphothreonineCombined sources1
Modified residuei664PhosphoserineCombined sources1
Modified residuei798PhosphoserineCombined sources1
Modified residuei834PhosphoserineCombined sources1
Modified residuei868PhosphoserineCombined sources1
Modified residuei881PhosphoserineCombined sources1
Modified residuei1052PhosphoserineCombined sources1
Modified residuei1126PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ96PY6.
PaxDbiQ96PY6.
PeptideAtlasiQ96PY6.
PRIDEiQ96PY6.
TopDownProteomicsiQ96PY6-3. [Q96PY6-3]

PTM databases

iPTMnetiQ96PY6.
PhosphoSitePlusiQ96PY6.

Expressioni

Tissue specificityi

High fetal expression in the brain and kidney.1 Publication

Gene expression databases

BgeeiENSG00000137601.
CleanExiHS_NEK1.
ExpressionAtlasiQ96PY6. baseline and differential.
GenevisibleiQ96PY6. HS.

Organism-specific databases

HPAiHPA020873.
HPA040413.

Interactioni

Subunit structurei

Binds to SPERT.Found in a complex with C21orf2, NEK1 and SPATA7 (PubMed:26167768). Interacts with NEK1 (PubMed:26167768).By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
FEZ1Q996892EBI-373615,EBI-396435
FEZ2Q9UHY82EBI-373615,EBI-396453
LRRK2Q5S0072EBI-373615,EBI-5323863

Protein-protein interaction databases

BioGridi110825. 29 interactors.
IntActiQ96PY6. 25 interactors.
STRINGi9606.ENSP00000424757.

Chemistry databases

BindingDBiQ96PY6.

Structurei

Secondary structure

11258
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 9Combined sources6
Beta strandi18 – 23Combined sources6
Turni24 – 26Combined sources3
Beta strandi29 – 36Combined sources8
Helixi42 – 57Combined sources16
Beta strandi66 – 72Combined sources7
Beta strandi75 – 81Combined sources7
Helixi88 – 94Combined sources7
Turni95 – 97Combined sources3
Helixi102 – 121Combined sources20
Helixi131 – 133Combined sources3
Beta strandi134 – 136Combined sources3
Beta strandi142 – 144Combined sources3
Beta strandi149 – 151Combined sources3
Helixi155 – 164Combined sources10
Helixi172 – 175Combined sources4
Helixi182 – 198Combined sources17
Helixi208 – 217Combined sources10
Helixi229 – 238Combined sources10
Helixi243 – 245Combined sources3
Helixi249 – 253Combined sources5
Helixi256 – 259Combined sources4
Helixi260 – 264Combined sources5
Helixi268 – 275Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4APCX-ray2.10A/B1-328[»]
4B9DX-ray1.90A/B1-328[»]
ProteinModelPortaliQ96PY6.
SMRiQ96PY6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 258Protein kinasePROSITE-ProRule annotationAdd BLAST255

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0589. Eukaryota.
ENOG410Y7JF. LUCA.
GeneTreeiENSGT00760000118997.
HOVERGENiHBG006460.
InParanoidiQ96PY6.
KOiK08857.
OMAiKHKQAHQ.
OrthoDBiEOG091G0GU4.
PhylomeDBiQ96PY6.
TreeFamiTF333575.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96PY6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEKYVRLQKI GEGSFGKAIL VKSTEDGRQY VIKEINISRM SSKEREESRR
60 70 80 90 100
EVAVLANMKH PNIVQYRESF EENGSLYIVM DYCEGGDLFK RINAQKGVLF
110 120 130 140 150
QEDQILDWFV QICLALKHVH DRKILHRDIK SQNIFLTKDG TVQLGDFGIA
160 170 180 190 200
RVLNSTVELA RTCIGTPYYL SPEICENKPY NNKSDIWALG CVLYELCTLK
210 220 230 240 250
HAFEAGSMKN LVLKIISGSF PPVSLHYSYD LRSLVSQLFK RNPRDRPSVN
260 270 280 290 300
SILEKGFIAK RIEKFLSPQL IAEEFCLKTF SKFGSQPIPA KRPASGQNSI
310 320 330 340 350
SVMPAQKITK PAAKYGIPLA YKKYGDKKLH EKKPLQKHKQ AHQTPEKRVN
360 370 380 390 400
TGEERRKISE EAARKRRLEF IEKEKKQKDQ IISLMKAEQM KRQEKERLER
410 420 430 440 450
INRAREQGWR NVLSAGGSGE VKAPFLGSGG TIAPSSFSSR GQYEHYHAIF
460 470 480 490 500
DQMQQQRAED NEAKWKREIY GRGLPERGIL PGVRPGFPYG AAGHHHFPDA
510 520 530 540 550
DDIRKTLKRL KAVSKQANAN RQKGQLAVER AKQVEEFLQR KREAMQNKAR
560 570 580 590 600
AEGHMVYLAR LRQIRLQNFN ERQQIKAKLR GEKKEANHSE GQEGSEEADM
610 620 630 640 650
RRKKIESLKA HANARAAVLK EQLERKRKEA YEREKKVWEE HLVAKGVKSS
660 670 680 690 700
DVSPPLGQHE TGGSPSKQQM RSVISVTSAL KEVGVDSSLT DTRETSEEMQ
710 720 730 740 750
KTNNAISSKR EILRRLNENL KAQEDEKGKQ NLSDTFEINV HEDAKEHEKE
760 770 780 790 800
KSVSSDRKKW EAGGQLVIPL DELTLDTSFS TTERHTVGEV IKLGPNGSPR
810 820 830 840 850
RAWGKSPTDS VLKILGEAEL QLQTELLENT TIRSEISPEG EKYKPLITGE
860 870 880 890 900
KKVQCISHEI NPSAIVDSPV ETKSPEFSEA SPQMSLKLEG NLEEPDDLET
910 920 930 940 950
EILQEPSGTN KDESLPCTIT DVWISEEKET KETQSADRIT IQENEVSEDG
960 970 980 990 1000
VSSTVDQLSD IHIEPGTNDS QHSKCDVDKS VQPEPFFHKV VHSEHLNLVP
1010 1020 1030 1040 1050
QVQSVQCSPE ESFAFRSHSH LPPKNKNKNS LLIGLSTGLF DANNPKMLRT
1060 1070 1080 1090 1100
CSLPDLSKLF RTLMDVPTVG DVRQDNLEID EIEDENIKEG PSDSEDIVFE
1110 1120 1130 1140 1150
ETDTDLQELQ ASMEQLLREQ PGEEYSEEEE SVLKNSDVEP TANGTDVADE
1160 1170 1180 1190 1200
DDNPSSESAL NEEWHSDNSD GEIASECECD SVFNHLEELR LHLEQEMGFE
1210 1220 1230 1240 1250
KFFEVYEKIK AIHEDEDENI EICSKIVQNI LGNEHQHLYA KILHLVMADG

AYQEDNDE
Length:1,258
Mass (Da):142,828
Last modified:August 13, 2002 - v2
Checksum:i339C4BFA56612530
GO
Isoform 2 (identifier: Q96PY6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     478-521: Missing.

Note: No experimental confirmation available.
Show »
Length:1,214
Mass (Da):138,068
Checksum:i347246AED3D9FD79
GO
Isoform 3 (identifier: Q96PY6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     555-555: M → MGILQNLAAMYGGRPSSSRGGKPRNKEEE

Note: No experimental confirmation available.
Show »
Length:1,286
Mass (Da):145,814
Checksum:iF94B3F9C0666059D
GO
Isoform 4 (identifier: Q96PY6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     398-422: Missing.
     477-520: Missing.

Note: No experimental confirmation available.
Show »
Length:1,189
Mass (Da):135,303
Checksum:iCAE13631DC2A2151
GO
Isoform 5 (identifier: Q96PY6-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     522-527: QKGQLA → LDCDDP
     528-1258: Missing.

Note: No experimental confirmation available.
Show »
Length:527
Mass (Da):60,250
Checksum:i47E0707A533EE57C
GO
Isoform 6 (identifier: Q96PY6-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     477-520: Missing.
     555-555: M → MGILQNLAAMYGGRPSSSRGGKPRNKEEE

Note: No experimental confirmation available.
Show »
Length:1,242
Mass (Da):141,053
Checksum:i5CB4B464CF15573C
GO

Sequence cautioni

The sequence AAH15147 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAB15207 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB55209 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB67794 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti250N → D in CAI45943 (PubMed:17974005).Curated1
Sequence conflicti602R → RK in CAI45943 (PubMed:17974005).Curated1
Sequence conflicti1232G → E in AAD42879 (PubMed:10508479).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04090010I → F.1 PublicationCorresponds to variant rs34214559dbSNPEnsembl.1
Natural variantiVAR_04090125E → K in a lung large cell carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_04090276L → V.1 PublicationCorresponds to variant rs35093214dbSNPEnsembl.1
Natural variantiVAR_069617145G → R in SRTD6. 1 PublicationCorresponds to variant rs431905508dbSNPEnsembl.1
Natural variantiVAR_069618253L → S in SRTD6. 1 Publication1
Natural variantiVAR_040903294A → P in a lung adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_040904355R → G.1 PublicationCorresponds to variant rs35763578dbSNPEnsembl.1
Natural variantiVAR_040905463A → V.1 PublicationCorresponds to variant rs34540355dbSNPEnsembl.1
Natural variantiVAR_046486598A → T.1 PublicationCorresponds to variant rs33933790dbSNPEnsembl.1
Natural variantiVAR_061743717N → K.Corresponds to variant rs34324114dbSNPEnsembl.1
Natural variantiVAR_051651724E → G.2 PublicationsCorresponds to variant rs34099167dbSNPEnsembl.1
Natural variantiVAR_040906745K → N.1 Publication1
Natural variantiVAR_046488883Q → E.1 PublicationCorresponds to variant rs6828134dbSNPEnsembl.1
Natural variantiVAR_0464891180D → N.1 PublicationCorresponds to variant rs35503975dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_035435398 – 422Missing in isoform 4. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_035436477 – 520Missing in isoform 4 and isoform 6. 1 PublicationAdd BLAST44
Alternative sequenceiVSP_004870478 – 521Missing in isoform 2. 1 PublicationAdd BLAST44
Alternative sequenceiVSP_035437522 – 527QKGQLA → LDCDDP in isoform 5. 1 Publication6
Alternative sequenceiVSP_035438528 – 1258Missing in isoform 5. 1 PublicationAdd BLAST731
Alternative sequenceiVSP_035439555M → MGILQNLAAMYGGRPSSSRG GKPRNKEEE in isoform 3 and isoform 6. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB067488 mRNA. Translation: BAB67794.1. Different initiation.
CR933642 mRNA. Translation: CAI45943.1.
AC116615 Genomic DNA. No translation available.
AC116621 Genomic DNA. No translation available.
AC084724 Genomic DNA. No translation available.
CH471056 Genomic DNA. Translation: EAX04791.1.
BC015147 mRNA. Translation: AAH15147.1. Sequence problems.
BC037790 mRNA. Translation: AAH37790.1.
BC114491 mRNA. Translation: AAI14492.1.
AK025658 mRNA. Translation: BAB15207.1. Different initiation.
AK027580 mRNA. Translation: BAB55209.1. Different initiation.
AF155113 mRNA. Translation: AAD42879.1.
CCDSiCCDS47162.1. [Q96PY6-1]
CCDS56348.1. [Q96PY6-4]
CCDS56349.1. [Q96PY6-2]
CCDS56350.1. [Q96PY6-6]
CCDS56351.1. [Q96PY6-3]
RefSeqiNP_001186326.1. NM_001199397.1. [Q96PY6-3]
NP_001186327.1. NM_001199398.1. [Q96PY6-6]
NP_001186328.1. NM_001199399.1. [Q96PY6-4]
NP_001186329.1. NM_001199400.1. [Q96PY6-2]
NP_036356.1. NM_012224.2. [Q96PY6-1]
XP_011530305.1. XM_011532003.1. [Q96PY6-1]
XP_011530306.1. XM_011532004.1. [Q96PY6-2]
UniGeneiHs.481181.

Genome annotation databases

EnsembliENST00000439128; ENSP00000408020; ENSG00000137601. [Q96PY6-1]
ENST00000507142; ENSP00000424757; ENSG00000137601. [Q96PY6-3]
ENST00000510533; ENSP00000427653; ENSG00000137601. [Q96PY6-2]
ENST00000511633; ENSP00000423332; ENSG00000137601. [Q96PY6-6]
ENST00000512193; ENSP00000424938; ENSG00000137601. [Q96PY6-4]
GeneIDi4750.
KEGGihsa:4750.
UCSCiuc003isb.3. human. [Q96PY6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB067488 mRNA. Translation: BAB67794.1. Different initiation.
CR933642 mRNA. Translation: CAI45943.1.
AC116615 Genomic DNA. No translation available.
AC116621 Genomic DNA. No translation available.
AC084724 Genomic DNA. No translation available.
CH471056 Genomic DNA. Translation: EAX04791.1.
BC015147 mRNA. Translation: AAH15147.1. Sequence problems.
BC037790 mRNA. Translation: AAH37790.1.
BC114491 mRNA. Translation: AAI14492.1.
AK025658 mRNA. Translation: BAB15207.1. Different initiation.
AK027580 mRNA. Translation: BAB55209.1. Different initiation.
AF155113 mRNA. Translation: AAD42879.1.
CCDSiCCDS47162.1. [Q96PY6-1]
CCDS56348.1. [Q96PY6-4]
CCDS56349.1. [Q96PY6-2]
CCDS56350.1. [Q96PY6-6]
CCDS56351.1. [Q96PY6-3]
RefSeqiNP_001186326.1. NM_001199397.1. [Q96PY6-3]
NP_001186327.1. NM_001199398.1. [Q96PY6-6]
NP_001186328.1. NM_001199399.1. [Q96PY6-4]
NP_001186329.1. NM_001199400.1. [Q96PY6-2]
NP_036356.1. NM_012224.2. [Q96PY6-1]
XP_011530305.1. XM_011532003.1. [Q96PY6-1]
XP_011530306.1. XM_011532004.1. [Q96PY6-2]
UniGeneiHs.481181.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4APCX-ray2.10A/B1-328[»]
4B9DX-ray1.90A/B1-328[»]
ProteinModelPortaliQ96PY6.
SMRiQ96PY6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110825. 29 interactors.
IntActiQ96PY6. 25 interactors.
STRINGi9606.ENSP00000424757.

Chemistry databases

BindingDBiQ96PY6.
ChEMBLiCHEMBL5855.
GuidetoPHARMACOLOGYi2114.

PTM databases

iPTMnetiQ96PY6.
PhosphoSitePlusiQ96PY6.

Polymorphism and mutation databases

BioMutaiNEK1.
DMDMi22256934.

Proteomic databases

MaxQBiQ96PY6.
PaxDbiQ96PY6.
PeptideAtlasiQ96PY6.
PRIDEiQ96PY6.
TopDownProteomicsiQ96PY6-3. [Q96PY6-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000439128; ENSP00000408020; ENSG00000137601. [Q96PY6-1]
ENST00000507142; ENSP00000424757; ENSG00000137601. [Q96PY6-3]
ENST00000510533; ENSP00000427653; ENSG00000137601. [Q96PY6-2]
ENST00000511633; ENSP00000423332; ENSG00000137601. [Q96PY6-6]
ENST00000512193; ENSP00000424938; ENSG00000137601. [Q96PY6-4]
GeneIDi4750.
KEGGihsa:4750.
UCSCiuc003isb.3. human. [Q96PY6-1]

Organism-specific databases

CTDi4750.
DisGeNETi4750.
GeneCardsiNEK1.
HGNCiHGNC:7744. NEK1.
HPAiHPA020873.
HPA040413.
MalaCardsiNEK1.
MIMi263520. phenotype.
604588. gene.
neXtProtiNX_Q96PY6.
OpenTargetsiENSG00000137601.
Orphaneti93269. Short rib-polydactyly syndrome, Majewski type.
PharmGKBiPA31545.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0589. Eukaryota.
ENOG410Y7JF. LUCA.
GeneTreeiENSGT00760000118997.
HOVERGENiHBG006460.
InParanoidiQ96PY6.
KOiK08857.
OMAiKHKQAHQ.
OrthoDBiEOG091G0GU4.
PhylomeDBiQ96PY6.
TreeFamiTF333575.

Enzyme and pathway databases

BioCyciZFISH:HS06366-MONOMER.
SignaLinkiQ96PY6.
SIGNORiQ96PY6.

Miscellaneous databases

ChiTaRSiNEK1. human.
GeneWikiiNEK1.
GenomeRNAii4750.
PROiQ96PY6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000137601.
CleanExiHS_NEK1.
ExpressionAtlasiQ96PY6. baseline and differential.
GenevisibleiQ96PY6. HS.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNEK1_HUMAN
AccessioniPrimary (citable) accession number: Q96PY6
Secondary accession number(s): G5E9Z3
, Q05DG5, Q14CB7, Q5H9T1, Q6PIB8, Q96SS2, Q9H6P7, Q9Y594
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 2002
Last sequence update: August 13, 2002
Last modified: November 30, 2016
This is version 157 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.