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Protein

Pleckstrin homology domain-containing family G member 4B

Gene

PLEKHG4B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Pleckstrin homology domain-containing family G member 4B
Short name:
PH domain-containing family G member 4B
Gene namesi
Name:PLEKHG4B
Synonyms:KIAA1909
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:29399. PLEKHG4B.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162399667.

Polymorphism and mutation databases

BioMutaiPLEKHG4B.
DMDMi296439496.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12711271Pleckstrin homology domain-containing family G member 4BPRO_0000317286Add
BLAST

Proteomic databases

EPDiQ96PX9.
MaxQBiQ96PX9.
PaxDbiQ96PX9.
PeptideAtlasiQ96PX9.
PRIDEiQ96PX9.

PTM databases

iPTMnetiQ96PX9.
PhosphoSiteiQ96PX9.

Expressioni

Gene expression databases

BgeeiQ96PX9.
CleanExiHS_PLEKHG4B.
ExpressionAtlasiQ96PX9. baseline and differential.
GenevisibleiQ96PX9. HS.

Organism-specific databases

HPAiHPA036274.
HPA058157.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000283426.

Structurei

3D structure databases

ProteinModelPortaliQ96PX9.
SMRiQ96PX9. Positions 807-1112.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini805 – 984180DHPROSITE-ProRule annotationAdd
BLAST
Domaini996 – 1104109PHPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1172 – 123362Ser-richAdd
BLAST

Sequence similaritiesi

Contains 1 DH (DBL-homology) domain.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0689. Eukaryota.
KOG4240. Eukaryota.
ENOG410XSWY. LUCA.
GeneTreeiENSGT00760000119030.
HOGENOMiHOG000169189.
InParanoidiQ96PX9.
OMAiHSPWSSD.
OrthoDBiEOG70ZZMJ.
PhylomeDBiQ96PX9.
TreeFamiTF334329.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR000219. DH-domain.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96PX9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEALRNPMPL GSSEEALGDL ACSSLTGASR DLGTGAVASG TQEETSGPRG
60 70 80 90 100
DPQQTPSLEK ERHTPSRTGP GAAGRTLPRR SRSWERAPRS SRGAQAAACH
110 120 130 140 150
TSHHSAGSRP GGHLGGQAVG TPNCVPVEGP GCTKEEDVLA SSACVSTDGG
160 170 180 190 200
SLHCHNPSGP SDVPARQPHP EQEGWPPGTG DFPSQVPKQV LDVSQELLQS
210 220 230 240 250
GVVTLPGTRD RHGRAVVQVR TRSLLWTREH SSCAELTRLL LYFHSIPRKE
260 270 280 290 300
VRDLGLVVLV DARRSPAAPA VSQALSGLQN NTSPIIHSIL LLVDKESAFR
310 320 330 340 350
PDKDAIIQCE VVSSLKAVHK FVDSCQLTAD LDGSFPYSHG DWICFRQRLE
360 370 380 390 400
HFAANCEEAI IFLQNSFCSL NTHRTPRTAQ EVAELIDQHE TMMKLVLEDP
410 420 430 440 450
LLVSLRLEGG TVLARLRREE LGTEDSRDTL EAATSLYDRV DEEVHRLVLT
460 470 480 490 500
SNNRLQQLEH LRELASLLEG NDQQSCQKGL QLAKENPQRT EEMVQDFRRG
510 520 530 540 550
LSAVVSQAEC REGELARWTR SSELCETVSS WMGPLDPEAC PSSPVAECLR
560 570 580 590 600
SCHQEATSVA AEAFPGAGVA VLKPHALGKP WASQQDLWLQ YPQTRLRLEE
610 620 630 640 650
ALSEAAPDPS LPPLAQSPPK HERAQEAMRR HQKPPSFPST DSGGGAWEPA
660 670 680 690 700
QPLSGLPGRA LLCGQDGETL RPGLCALWDP LSLLRGLPGA GATTAHLEDS
710 720 730 740 750
SACSSEPTQT LASRPRKHPQ KKMIKKTQSF EIPQPDSGPR DSCQPDHTSV
760 770 780 790 800
FSKGLEVTST VATEKKLPLW QHARSPPVTQ SRSLSSPSGL HPAEEDGRQQ
810 820 830 840 850
VGSSRLRHIM AEMIATEREY IRCLGYVIDN YFPEMERMDL PQGLRGKHHV
860 870 880 890 900
IFGNLEKLHD FHQQHFLREL ERCQHCPLAV GRSFLRHEEQ FGMYVIYSKN
910 920 930 940 950
KPQSDALLSS HGNAFFKDKQ RELGDKMDLA SYLLRPVQRV AKYALLLQDL
960 970 980 990 1000
LKEASCGLAQ GQELGELRAA EVVVCFQLRH GNDLLAMDAI RGCDVNLKEQ
1010 1020 1030 1040 1050
GQLRCRDEFI VCCGRKKYLR HVFLFEDLIL FSKTQKVEGS HDVYLYKQSF
1060 1070 1080 1090 1100
KTAEIGMTEN VGDSGLRFEI WFRRRRKSQD TYILQASSAE VKSAWTDVIG
1110 1120 1130 1140 1150
RILWRQALKS RELRIQEMAS MGIGNQPFMD VKPRDRTPDC AVISDRAPKC
1160 1170 1180 1190 1200
AVMSDRVPDS IVKGTESQMR GSTAVSSSDH AAPFKRPHST ISDSSTSSSS
1210 1220 1230 1240 1250
SQSSSILGSL GLLVSSSPAH PGLWSPAHSP WSSDIRACVE EDEPEPELET
1260 1270
GTQAAVCEGA PAVLLSRTRQ A
Length:1,271
Mass (Da):139,667
Last modified:May 18, 2010 - v4
Checksum:i242509412ACEF3A5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti671 – 6711R → G in BAB67802 (PubMed:11572484).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti37 – 371V → A.
Corresponds to variant rs12516846 [ dbSNP | Ensembl ].
VAR_059547
Natural varianti72 – 721A → T.
Corresponds to variant rs12523402 [ dbSNP | Ensembl ].
VAR_056672
Natural varianti149 – 1491G → S.
Corresponds to variant rs11949577 [ dbSNP | Ensembl ].
VAR_056673
Natural varianti220 – 2201R → H.
Corresponds to variant rs13436090 [ dbSNP | Ensembl ].
VAR_056674
Natural varianti660 – 6601A → V.
Corresponds to variant rs3810869 [ dbSNP | Ensembl ].
VAR_056675
Natural varianti669 – 6691T → P.1 Publication
Corresponds to variant rs29674 [ dbSNP | Ensembl ].
VAR_060453
Natural varianti1076 – 10761R → Q.1 Publication
Corresponds to variant rs4956987 [ dbSNP | Ensembl ].
VAR_060454
Natural varianti1146 – 11461R → G.1 Publication
Corresponds to variant rs12519352 [ dbSNP | Ensembl ].
VAR_060455

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB067496 mRNA. Translation: BAB67802.2.
AC010443 Genomic DNA. No translation available.
AC021087 Genomic DNA. No translation available.
CCDSiCCDS34124.1.
RefSeqiNP_443141.3. NM_052909.3.
UniGeneiHs.535800.

Genome annotation databases

EnsembliENST00000283426; ENSP00000283426; ENSG00000153404.
GeneIDi153478.
KEGGihsa:153478.
UCSCiuc003jak.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB067496 mRNA. Translation: BAB67802.2.
AC010443 Genomic DNA. No translation available.
AC021087 Genomic DNA. No translation available.
CCDSiCCDS34124.1.
RefSeqiNP_443141.3. NM_052909.3.
UniGeneiHs.535800.

3D structure databases

ProteinModelPortaliQ96PX9.
SMRiQ96PX9. Positions 807-1112.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000283426.

PTM databases

iPTMnetiQ96PX9.
PhosphoSiteiQ96PX9.

Polymorphism and mutation databases

BioMutaiPLEKHG4B.
DMDMi296439496.

Proteomic databases

EPDiQ96PX9.
MaxQBiQ96PX9.
PaxDbiQ96PX9.
PeptideAtlasiQ96PX9.
PRIDEiQ96PX9.

Protocols and materials databases

DNASUi153478.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000283426; ENSP00000283426; ENSG00000153404.
GeneIDi153478.
KEGGihsa:153478.
UCSCiuc003jak.3. human.

Organism-specific databases

CTDi153478.
GeneCardsiPLEKHG4B.
H-InvDBHIX0004696.
HGNCiHGNC:29399. PLEKHG4B.
HPAiHPA036274.
HPA058157.
neXtProtiNX_Q96PX9.
PharmGKBiPA162399667.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0689. Eukaryota.
KOG4240. Eukaryota.
ENOG410XSWY. LUCA.
GeneTreeiENSGT00760000119030.
HOGENOMiHOG000169189.
InParanoidiQ96PX9.
OMAiHSPWSSD.
OrthoDBiEOG70ZZMJ.
PhylomeDBiQ96PX9.
TreeFamiTF334329.

Miscellaneous databases

GenomeRNAii153478.
PROiQ96PX9.

Gene expression databases

BgeeiQ96PX9.
CleanExiHS_PLEKHG4B.
ExpressionAtlasiQ96PX9. baseline and differential.
GenevisibleiQ96PX9. HS.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR000219. DH-domain.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins."
    Nagase T., Kikuno R., Ohara O.
    DNA Res. 8:179-187(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS PRO-669; GLN-1076 AND GLY-1146.
    Tissue: Brain.
  2. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiPKH4B_HUMAN
AccessioniPrimary (citable) accession number: Q96PX9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 18, 2010
Last modified: July 6, 2016
This is version 93 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.