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Protein

Coiled-coil domain-containing protein 85A

Gene

CCDC85A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 85A
Gene namesi
Name:CCDC85A
Synonyms:KIAA1912
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:29400. CCDC85A.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA144596452.

Polymorphism and mutation databases

BioMutaiCCDC85A.
DMDMi296439418.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 553553Coiled-coil domain-containing protein 85APRO_0000271104Add
BLAST

Proteomic databases

PaxDbiQ96PX6.
PRIDEiQ96PX6.

PTM databases

iPTMnetiQ96PX6.
PhosphoSiteiQ96PX6.

Expressioni

Gene expression databases

BgeeiQ96PX6.
CleanExiHS_CCDC85A.
GenevisibleiQ96PX6. HS.

Organism-specific databases

HPAiHPA043106.

Interactioni

Protein-protein interaction databases

BioGridi125361. 3 interactions.
IntActiQ96PX6. 3 interactions.
MINTiMINT-8247574.
STRINGi9606.ENSP00000384040.

Structurei

3D structure databases

ProteinModelPortaliQ96PX6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili43 – 10967Sequence analysisAdd
BLAST
Coiled coili137 – 16933Sequence analysisAdd
BLAST
Coiled coili412 – 44332Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi4 – 3128Ala-richAdd
BLAST
Compositional biasi224 – 374151His-richAdd
BLAST

Sequence similaritiesi

Belongs to the CCDC85 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3819. Eukaryota.
ENOG410YXPD. LUCA.
GeneTreeiENSGT00390000003531.
HOGENOMiHOG000294096.
HOVERGENiHBG060368.
InParanoidiQ96PX6.
OMAiQKPRSEG.
OrthoDBiEOG7N8ZVM.
PhylomeDBiQ96PX6.
TreeFamiTF320243.

Family and domain databases

InterProiIPR019359. CCDC85.
[Graphical view]
PfamiPF10226. DUF2216. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96PX6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKAAGGAAA AAAAAESCSP APAGSSAAPP APVEDLSKVS DEELLQWSKE
60 70 80 90 100
ELIRSLRRAE AEKVSAMLDH SNLIREVNRR LQLHLGEIRG LKDINQKLQE
110 120 130 140 150
DNQELRDLCC FLDDDRQKGK RVSREWQRLG RYTAGVMHKE VALYLQKLKD
160 170 180 190 200
LEVKQEEVVK ENMELKELCV LLDEEKGAGC AGSRCSIDSQ ASLCQLTAST
210 220 230 240 250
APYVRDVGDG SSTSSTGSTD SPDHHKHHAS SGSPEHLQKP RSEGSPEHSK
260 270 280 290 300
HRSASPEHPQ KPRACGTPDR PKALKGPSPE HHKPLCKGSP EQQRHPHPGS
310 320 330 340 350
SPETLPKHVL SGSPEHFQKH RSGSSPEHAR HSGGSPEHLQ KHALGGSLEH
360 370 380 390 400
LPRARGTSPE HLKQHYGGSP DHKHGGGSGG SGGSGGGSRE GTLRRQAQED
410 420 430 440 450
GSPHHRNVYS GMNESTLSYV RQLEARVRQL EEENRMLPQA SQNRRQPPTR
460 470 480 490 500
NSSNMEKGWG SRARRVLQWW QGCRGIGRCL PTLPGSFRLS SGADGSNSSP
510 520 530 540 550
NSAASFSGHA TPSQQPEPVV HSLKVVWRKL GDAAGSCPGI RQHLSGNQYK

GPM
Length:553
Mass (Da):59,976
Last modified:May 18, 2010 - v3
Checksum:iFE620905745A556A
GO

Sequence cautioni

The sequence BAB67805.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti20 – 201P → S in BAB67805 (PubMed:11572484).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB067499 mRNA. Translation: BAB67805.1. Different initiation.
AC007743 Genomic DNA. No translation available.
AC007744 Genomic DNA. No translation available.
CCDSiCCDS46290.1.
RefSeqiNP_001073902.1. NM_001080433.1.
UniGeneiHs.117136.

Genome annotation databases

EnsembliENST00000407595; ENSP00000384040; ENSG00000055813.
GeneIDi114800.
KEGGihsa:114800.
UCSCiuc002rzn.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB067499 mRNA. Translation: BAB67805.1. Different initiation.
AC007743 Genomic DNA. No translation available.
AC007744 Genomic DNA. No translation available.
CCDSiCCDS46290.1.
RefSeqiNP_001073902.1. NM_001080433.1.
UniGeneiHs.117136.

3D structure databases

ProteinModelPortaliQ96PX6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125361. 3 interactions.
IntActiQ96PX6. 3 interactions.
MINTiMINT-8247574.
STRINGi9606.ENSP00000384040.

PTM databases

iPTMnetiQ96PX6.
PhosphoSiteiQ96PX6.

Polymorphism and mutation databases

BioMutaiCCDC85A.
DMDMi296439418.

Proteomic databases

PaxDbiQ96PX6.
PRIDEiQ96PX6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000407595; ENSP00000384040; ENSG00000055813.
GeneIDi114800.
KEGGihsa:114800.
UCSCiuc002rzn.4. human.

Organism-specific databases

CTDi114800.
GeneCardsiCCDC85A.
H-InvDBHIX0002068.
HIX0021082.
HGNCiHGNC:29400. CCDC85A.
HPAiHPA043106.
neXtProtiNX_Q96PX6.
PharmGKBiPA144596452.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3819. Eukaryota.
ENOG410YXPD. LUCA.
GeneTreeiENSGT00390000003531.
HOGENOMiHOG000294096.
HOVERGENiHBG060368.
InParanoidiQ96PX6.
OMAiQKPRSEG.
OrthoDBiEOG7N8ZVM.
PhylomeDBiQ96PX6.
TreeFamiTF320243.

Miscellaneous databases

ChiTaRSiCCDC85A. human.
GenomeRNAii114800.
PROiQ96PX6.

Gene expression databases

BgeeiQ96PX6.
CleanExiHS_CCDC85A.
GenevisibleiQ96PX6. HS.

Family and domain databases

InterProiIPR019359. CCDC85.
[Graphical view]
PfamiPF10226. DUF2216. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins."
    Nagase T., Kikuno R., Ohara O.
    DNA Res. 8:179-187(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiCC85A_HUMAN
AccessioniPrimary (citable) accession number: Q96PX6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: May 18, 2010
Last modified: June 8, 2016
This is version 80 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.