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Protein

RING finger protein 157

Gene

RNF157

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri277 – 31640RING-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RING finger protein 157
Gene namesi
Name:RNF157
Synonyms:KIAA1917
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:29402. RNF157.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134974884.

Polymorphism and mutation databases

BioMutaiRNF157.
DMDMi118573798.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved
Chaini2 – 679678RING finger protein 157PRO_0000261614Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycine1 Publication

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

PaxDbiQ96PX1.
PeptideAtlasiQ96PX1.
PRIDEiQ96PX1.

PTM databases

iPTMnetiQ96PX1.
PhosphoSiteiQ96PX1.

Expressioni

Gene expression databases

BgeeiENSG00000141576.
CleanExiHS_RNF157.
ExpressionAtlasiQ96PX1. baseline and differential.
GenevisibleiQ96PX1. HS.

Organism-specific databases

HPAiHPA021854.
HPA021991.
HPA023922.

Interactioni

Protein-protein interaction databases

BioGridi125364. 1 interaction.
IntActiQ96PX1. 1 interaction.
STRINGi9606.ENSP00000269391.

Structurei

3D structure databases

ProteinModelPortaliQ96PX1.
SMRiQ96PX1. Positions 275-321.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi420 – 538119Ser-richAdd
BLAST

Sequence similaritiesi

Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri277 – 31640RING-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG4265. Eukaryota.
ENOG410XRAE. LUCA.
GeneTreeiENSGT00390000009925.
HOGENOMiHOG000231196.
HOVERGENiHBG061762.
InParanoidiQ96PX1.
OMAiMECDNNN.
OrthoDBiEOG091G08LF.
PhylomeDBiQ96PX1.
TreeFamiTF314969.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96PX1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGALTSRQHA GVEEVDIPSN SVYRYPPKSG SYFASHFIMG GEKFDSTHPE
60 70 80 90 100
GYLFGENSDL NFLGNRPVVF PYAAPPPQEP VKTLRSLVNI RKDTLRLVKC
110 120 130 140 150
AEEVKSPGEE ASKAKVHYNV EFTFDTDARV AITIYYQATE EFQNGIASYI
160 170 180 190 200
PKDNSLQSET VQYKRGVCQQ FCLPSHTVDP SEWAEEELGF DLDREVYPLV
210 220 230 240 250
VHAVVDEGDE YFGHCHVLLG TFEKHTDGTF CVKPLKQKQV VDGVSYLLQE
260 270 280 290 300
IYGIENKYNT QDSKVAEDEV SDNSAECVVC LSDVRDTLIL PCRHLCLCNT
310 320 330 340 350
CADTLRYQAN NCPICRLPFR ALLQIRAMRK KLGPLSPTSF NPIISSQTSD
360 370 380 390 400
SEEHPSSENI PPGYEVVSLL EALNGPLTPS PAVPPLHVLG DGHLSGMLPS
410 420 430 440 450
YGSDGHLPPV RTISPLDRLS DSSSQGLKLK KSLSKSTSQN SSVLHEEEDE
460 470 480 490 500
HSCSESETQL SQRPSVQHLG EECGVTPESE NLTLSSSGAI DQSSCTGTPL
510 520 530 540 550
SSTISSPEGP ASSSLAQSVM SMASSQISTD TVSSMSGSYI APGTEEEGEA
560 570 580 590 600
LSSPQPASRA PSEEGEGLPA ESPDSNFAGL PAGEQDAEGN DVIEEEDGSP
610 620 630 640 650
TQEGQRTCAF LGMECDNNND FDIASVKALD NKLCSEVCLP GAWQADDNAV
660 670
SRNAQRRRLS SSSLEDSETR PCVWGPLAV
Length:679
Mass (Da):73,579
Last modified:November 28, 2006 - v3
Checksum:i44CE214D4CB7620D
GO
Isoform 2 (identifier: Q96PX1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     568-589: Missing.

Note: No experimental confirmation available.
Show »
Length:657
Mass (Da):71,425
Checksum:i7AAFCB38C7B5158E
GO

Sequence cautioni

The sequence BAB67810 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAB71053 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAC03669 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti80 – 801P → H.
Corresponds to variant rs2289602 [ dbSNP | Ensembl ].
VAR_029458
Natural varianti208 – 2081G → R.
Corresponds to variant rs11539879 [ dbSNP | Ensembl ].
VAR_029459
Natural varianti596 – 5961E → V.
Corresponds to variant rs59053255 [ dbSNP | Ensembl ].
VAR_061817

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei568 – 58922Missing in isoform 2. 1 PublicationVSP_021735Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB067504 mRNA. Translation: BAB67810.2. Different initiation.
AK055949 mRNA. Translation: BAB71053.1. Different initiation.
AK091467 mRNA. Translation: BAC03669.1. Different initiation.
CCDSiCCDS32740.1. [Q96PX1-1]
RefSeqiNP_443148.1. NM_052916.2. [Q96PX1-1]
UniGeneiHs.500643.

Genome annotation databases

EnsembliENST00000269391; ENSP00000269391; ENSG00000141576. [Q96PX1-1]
ENST00000319945; ENSP00000321837; ENSG00000141576. [Q96PX1-2]
GeneIDi114804.
KEGGihsa:114804.
UCSCiuc002jqz.4. human. [Q96PX1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB067504 mRNA. Translation: BAB67810.2. Different initiation.
AK055949 mRNA. Translation: BAB71053.1. Different initiation.
AK091467 mRNA. Translation: BAC03669.1. Different initiation.
CCDSiCCDS32740.1. [Q96PX1-1]
RefSeqiNP_443148.1. NM_052916.2. [Q96PX1-1]
UniGeneiHs.500643.

3D structure databases

ProteinModelPortaliQ96PX1.
SMRiQ96PX1. Positions 275-321.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125364. 1 interaction.
IntActiQ96PX1. 1 interaction.
STRINGi9606.ENSP00000269391.

PTM databases

iPTMnetiQ96PX1.
PhosphoSiteiQ96PX1.

Polymorphism and mutation databases

BioMutaiRNF157.
DMDMi118573798.

Proteomic databases

PaxDbiQ96PX1.
PeptideAtlasiQ96PX1.
PRIDEiQ96PX1.

Protocols and materials databases

DNASUi114804.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000269391; ENSP00000269391; ENSG00000141576. [Q96PX1-1]
ENST00000319945; ENSP00000321837; ENSG00000141576. [Q96PX1-2]
GeneIDi114804.
KEGGihsa:114804.
UCSCiuc002jqz.4. human. [Q96PX1-1]

Organism-specific databases

CTDi114804.
GeneCardsiRNF157.
HGNCiHGNC:29402. RNF157.
HPAiHPA021854.
HPA021991.
HPA023922.
neXtProtiNX_Q96PX1.
PharmGKBiPA134974884.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4265. Eukaryota.
ENOG410XRAE. LUCA.
GeneTreeiENSGT00390000009925.
HOGENOMiHOG000231196.
HOVERGENiHBG061762.
InParanoidiQ96PX1.
OMAiMECDNNN.
OrthoDBiEOG091G08LF.
PhylomeDBiQ96PX1.
TreeFamiTF314969.

Miscellaneous databases

ChiTaRSiRNF157. human.
GenomeRNAii114804.
PROiQ96PX1.

Gene expression databases

BgeeiENSG00000141576.
CleanExiHS_RNF157.
ExpressionAtlasiQ96PX1. baseline and differential.
GenevisibleiQ96PX1. HS.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRN157_HUMAN
AccessioniPrimary (citable) accession number: Q96PX1
Secondary accession number(s): Q8NB72, Q96N56
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 28, 2006
Last modified: September 7, 2016
This is version 100 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.