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Protein

E3 ubiquitin ligase RNF157

Gene

RNF157

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

E3 ubiquitin ligase that ubiquitinates APBB1 for its degradation by the proteasome and thus prevents apoptosis and promotes survival of neurons (PubMed:25342469). Has a dual role in neurons as it is also required for dendrite growth and maintenance for which its ligase activity is not critical (PubMed:25342469). May act as a scaffold molecule to regulate this process (PubMed:25342469). Acts as a downstream effector of the interconnected PI3K and MAPK signaling pathways and thus participates in the regulation of the cell cycle (PubMed:28655764).2 Publications

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri277 – 316RING-typePROSITE-ProRule annotationAdd BLAST40

GO - Molecular functioni

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin ligase RNF1571 Publication (EC:2.3.2.271 Publication)
Alternative name(s):
RING finger protein 157
RING-type E3 ubiquitin transferase RNF157Curated
Gene namesi
Name:RNF157
Synonyms:KIAA1917
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000141576.14
HGNCiHGNC:29402 RNF157
neXtProtiNX_Q96PX1

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi114804
OpenTargetsiENSG00000141576
PharmGKBiPA134974884

Polymorphism and mutation databases

BioMutaiRNF157
DMDMi118573798

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00002616142 – 679E3 ubiquitin ligase RNF157Add BLAST678

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine1 Publication1
Modified residuei660Phosphoserine1 Publication1
Modified residuei661Phosphoserine1 Publication1
Modified residuei662Phosphoserine1 Publication1
Modified residuei663Phosphoserine1 Publication1

Post-translational modificationi

Phosphorylation at Ser-660, Ser-661, Ser-662 and Ser-663 downstream of the PI3K and MAPK pathways influences the E3 ligase activity and stability of RNF157 during the cell cycle in an anaphase-promoting complex/cyclosome-CDH1-dependent manner (PubMed:28655764).1 Publication

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

MaxQBiQ96PX1
PaxDbiQ96PX1
PeptideAtlasiQ96PX1
PRIDEiQ96PX1

PTM databases

iPTMnetiQ96PX1
PhosphoSitePlusiQ96PX1

Expressioni

Inductioni

Expression is cell cycle-specific with higher levels in cells arrested in G1/S and G2/M (PubMed:28655764).1 Publication

Gene expression databases

BgeeiENSG00000141576
CleanExiHS_RNF157
ExpressionAtlasiQ96PX1 baseline and differential
GenevisibleiQ96PX1 HS

Organism-specific databases

HPAiHPA021854
HPA021991
HPA023922

Interactioni

Subunit structurei

Interacts with APBB1 (PubMed:25342469). Interact with CHD1; CHD1-binding controls RNF157 stability (PubMed:28655764). Interacts with ATRN, MEGF8, TECR, MSI2, PLRG1, BYSL, MTERF3, PSMA1, MRPS18B, PRPF4, FASTKD2, SLC25A1, SMU1, CNOT9, MRPS2, MAGT1, FXR2, EMD, PSMD8, HDAC1, RAN, HSD17B12, TXNDC5 AND MRPL19 (PubMed:28655764).2 Publications

Protein-protein interaction databases

BioGridi125364, 29 interactors
ELMiQ96PX1
IntActiQ96PX1, 1 interactor
STRINGi9606.ENSP00000269391

Structurei

3D structure databases

ProteinModelPortaliQ96PX1
SMRiQ96PX1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi329 – 332D-box 11 Publication4
Motifi656 – 659D-box 21 Publication4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi420 – 538Ser-richAdd BLAST119

Domaini

The D-box motifs play a key role in RNF157 stabilization (PubMed:28655764).1 Publication

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri277 – 316RING-typePROSITE-ProRule annotationAdd BLAST40

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG4265 Eukaryota
ENOG410XRAE LUCA
GeneTreeiENSGT00390000009925
HOGENOMiHOG000231196
HOVERGENiHBG061762
InParanoidiQ96PX1
OMAiKRGVCQQ
OrthoDBiEOG091G08LF
PhylomeDBiQ96PX1
TreeFamiTF314969

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
SMARTiView protein in SMART
SM00184 RING, 1 hit
PROSITEiView protein in PROSITE
PS50089 ZF_RING_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96PX1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGALTSRQHA GVEEVDIPSN SVYRYPPKSG SYFASHFIMG GEKFDSTHPE
60 70 80 90 100
GYLFGENSDL NFLGNRPVVF PYAAPPPQEP VKTLRSLVNI RKDTLRLVKC
110 120 130 140 150
AEEVKSPGEE ASKAKVHYNV EFTFDTDARV AITIYYQATE EFQNGIASYI
160 170 180 190 200
PKDNSLQSET VQYKRGVCQQ FCLPSHTVDP SEWAEEELGF DLDREVYPLV
210 220 230 240 250
VHAVVDEGDE YFGHCHVLLG TFEKHTDGTF CVKPLKQKQV VDGVSYLLQE
260 270 280 290 300
IYGIENKYNT QDSKVAEDEV SDNSAECVVC LSDVRDTLIL PCRHLCLCNT
310 320 330 340 350
CADTLRYQAN NCPICRLPFR ALLQIRAMRK KLGPLSPTSF NPIISSQTSD
360 370 380 390 400
SEEHPSSENI PPGYEVVSLL EALNGPLTPS PAVPPLHVLG DGHLSGMLPS
410 420 430 440 450
YGSDGHLPPV RTISPLDRLS DSSSQGLKLK KSLSKSTSQN SSVLHEEEDE
460 470 480 490 500
HSCSESETQL SQRPSVQHLG EECGVTPESE NLTLSSSGAI DQSSCTGTPL
510 520 530 540 550
SSTISSPEGP ASSSLAQSVM SMASSQISTD TVSSMSGSYI APGTEEEGEA
560 570 580 590 600
LSSPQPASRA PSEEGEGLPA ESPDSNFAGL PAGEQDAEGN DVIEEEDGSP
610 620 630 640 650
TQEGQRTCAF LGMECDNNND FDIASVKALD NKLCSEVCLP GAWQADDNAV
660 670
SRNAQRRRLS SSSLEDSETR PCVWGPLAV
Length:679
Mass (Da):73,579
Last modified:November 28, 2006 - v3
Checksum:i44CE214D4CB7620D
GO
Isoform 2 (identifier: Q96PX1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     568-589: Missing.

Note: No experimental confirmation available.
Show »
Length:657
Mass (Da):71,425
Checksum:i7AAFCB38C7B5158E
GO

Sequence cautioni

The sequence BAB67810 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB71053 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC03669 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02945880P → H. Corresponds to variant dbSNP:rs2289602Ensembl.1
Natural variantiVAR_029459208G → R. Corresponds to variant dbSNP:rs11539879Ensembl.1
Natural variantiVAR_061817596E → V. Corresponds to variant dbSNP:rs59053255Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_021735568 – 589Missing in isoform 2. 1 PublicationAdd BLAST22

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB067504 mRNA Translation: BAB67810.2 Different initiation.
AK055949 mRNA Translation: BAB71053.1 Different initiation.
AK091467 mRNA Translation: BAC03669.1 Different initiation.
CCDSiCCDS32740.1 [Q96PX1-1]
CCDS82208.1 [Q96PX1-2]
RefSeqiNP_001317430.1, NM_001330501.1 [Q96PX1-2]
NP_443148.1, NM_052916.2 [Q96PX1-1]
UniGeneiHs.500643

Genome annotation databases

EnsembliENST00000269391; ENSP00000269391; ENSG00000141576 [Q96PX1-1]
ENST00000319945; ENSP00000321837; ENSG00000141576 [Q96PX1-2]
GeneIDi114804
KEGGihsa:114804
UCSCiuc002jqz.4 human [Q96PX1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRN157_HUMAN
AccessioniPrimary (citable) accession number: Q96PX1
Secondary accession number(s): Q8NB72, Q96N56
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 28, 2006
Last modified: April 25, 2018
This is version 116 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

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