Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Leukocyte receptor cluster member 8

Gene

LENG8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Leukocyte receptor cluster member 8
Gene namesi
Name:LENG8
Synonyms:KIAA1932
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:15500. LENG8.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134903953.

Polymorphism and mutation databases

BioMutaiLENG8.
DMDMi158705886.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 779778Leukocyte receptor cluster member 8PRO_0000306391Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineCombined sources
Modified residuei314 – 3141PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ96PV6.
MaxQBiQ96PV6.
PeptideAtlasiQ96PV6.
PRIDEiQ96PV6.

PTM databases

iPTMnetiQ96PV6.
PhosphoSiteiQ96PV6.

Expressioni

Gene expression databases

BgeeiQ96PV6.
CleanExiHS_LENG8.
ExpressionAtlasiQ96PV6. baseline and differential.
GenevisibleiQ96PV6. HS.

Organism-specific databases

HPAiHPA042004.
HPA042056.
HPA061571.

Interactioni

Subunit structurei

May be part of a SHFM1-containing complex.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CEP70Q8NHQ13EBI-739546,EBI-739624
SNRPAP090123EBI-739546,EBI-607085

Protein-protein interaction databases

BioGridi125373. 35 interactions.
IntActiQ96PV6. 29 interactions.
MINTiMINT-1435849.

Structurei

3D structure databases

ProteinModelPortaliQ96PV6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi82 – 854Poly-Gln
Compositional biasi86 – 10318Tyr-richAdd
BLAST
Compositional biasi375 – 40935Ser-richAdd
BLAST

Phylogenomic databases

GeneTreeiENSGT00390000008006.
HOGENOMiHOG000001575.
HOVERGENiHBG070702.
InParanoidiQ96PV6.
OMAiVITNAIM.
PhylomeDBiQ96PV6.
TreeFamiTF312927.

Family and domain databases

InterProiIPR005062. SAC3/GANP/THP3.
[Graphical view]
PfamiPF03399. SAC3_GANP. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96PV6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAANVGDQRS TDWSSQYSMV AGAGRENGME TPMHENPEWE KARQALASIS
60 70 80 90 100
KSGAAGGSAK SSSNGPVASA QYVSQAEASA LQQQQYYQWY QQYNYAYPYS
110 120 130 140 150
YYYPMPPVPG MDESMSYQAP PQQLPSAQPP QPSNPPHGAH TLNSGPQPGT
160 170 180 190 200
APATQHSQAG PATGQAYGPH TYTEPAKPKK GQQLWNRMKP APGTGGLKFN
210 220 230 240 250
IQKRPFAVTT QSFGSNAEGQ HSGFGPQPNP EKVQNHSGSS ARGNLSGKPD
260 270 280 290 300
DWPQDMKEYV ERCFTACESE EDKDRTEKLL KEVLQARLQD GSAYTIDWSR
310 320 330 340 350
EPLPGLTREP VAESPKKKRW EAASSLHPPR GAGSATRGGG APSQRGTPGA
360 370 380 390 400
GGAGRARGNS FTKFGNRNVF MKDNSSSSST DSRSRSSSRS PTRHFRRSDS
410 420 430 440 450
HSDSDSSYSG NECHPVGRRN PPPKGRGGRG AHMDRGRGRA QRGKRHDLAP
460 470 480 490 500
TKRSRKKMAA LECEDPEREL KKQKRAARFQ HGHSRRLRLE PLVLQMSSLE
510 520 530 540 550
SSGADPDWQE LQIVGTCPDI TKHYLRLTCA PDPSTVRPVA VLKKSLCMVK
560 570 580 590 600
CHWKEKQDYA FACEQMKSIR QDLTVQGIRT EFTVEVYETH ARIALEKGDH
610 620 630 640 650
EEFNQCQTQL KSLYAENLPG NVGEFTAYRI LYYIFTKNSG DITTELAYLT
660 670 680 690 700
RELKADPCVA HALALRTAWA LGNYHRFFRL YCHAPCMSGY LVDKFADRER
710 720 730 740 750
KVALKAMIKT YVVPSSLLPL LFPSFRLVSS CIKLSPCPLL PLPPVFLLIF
760 770
FSPFPPSLSA FFPWFSTGKT VPLPPSSAM
Length:779
Mass (Da):86,129
Last modified:October 2, 2007 - v2
Checksum:i7001D773F93486A6
GO
Isoform 2 (identifier: Q96PV6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     105-105: M → MSMYQSYGSPSQYGMAGSYGSATPQQPSAPQHQGTLNQ
     711-779: YVVPSSLLPL...TVPLPPSSAM → FRPALPVSYL...RLSLAQLSAF

Show »
Length:800
Mass (Da):88,157
Checksum:iDCD37905D54D1544
GO
Isoform 3 (identifier: Q96PV6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     38-54: EWEKARQALASISKSGA → DNSSIDCRLSLAQLSAF
     55-779: Missing.

Show »
Length:54
Mass (Da):5,835
Checksum:i53D37F914A53FF36
GO

Sequence cautioni

The sequence BAB67825.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti242 – 2421R → P.
Corresponds to variant rs35061854 [ dbSNP | Ensembl ].
VAR_035294
Natural varianti520 – 5201I → V.
Corresponds to variant rs35336528 [ dbSNP | Ensembl ].
VAR_035295

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei38 – 5417EWEKA…SKSGA → DNSSIDCRLSLAQLSAF in isoform 3. 1 PublicationVSP_028460Add
BLAST
Alternative sequencei55 – 779725Missing in isoform 3. 1 PublicationVSP_028461Add
BLAST
Alternative sequencei105 – 1051M → MSMYQSYGSPSQYGMAGSYG SATPQQPSAPQHQGTLNQ in isoform 2. 1 PublicationVSP_028462
Alternative sequencei711 – 77969YVVPS…PSSAM → FRPALPVSYLQAELAFEGEA ACRAFLEPLGLAYTGPDNSS IDCRLSLAQLSAF in isoform 2. 1 PublicationVSP_028463Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB067519 mRNA. Translation: BAB67825.1. Different initiation.
AL834532 mRNA. Translation: CAD39188.2.
CU467002 Genomic DNA. Translation: CAQ08955.1.
CU207370 Genomic DNA. Translation: CAQ52433.1.
CH471135 Genomic DNA. Translation: EAW72248.1.
BC028048 mRNA. Translation: AAH28048.1.
CCDSiCCDS12894.1. [Q96PV6-2]
RefSeqiNP_443157.1. NM_052925.3. [Q96PV6-2]
XP_005258543.1. XM_005258486.3. [Q96PV6-2]
XP_005277301.1. XM_005277244.3. [Q96PV6-2]
XP_011524717.1. XM_011526415.1. [Q96PV6-2]
XP_011545403.1. XM_011547101.1. [Q96PV6-2]
UniGeneiHs.502378.
Hs.744596.

Genome annotation databases

EnsembliENST00000326764; ENSP00000318374; ENSG00000167615. [Q96PV6-2]
ENST00000617180; ENSP00000480663; ENSG00000276681. [Q96PV6-2]
ENST00000621306; ENSP00000478337; ENSG00000276458. [Q96PV6-2]
ENST00000622672; ENSP00000478975; ENSG00000274305. [Q96PV6-2]
GeneIDi114823.
KEGGihsa:114823.
UCSCiuc032iea.2. human. [Q96PV6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB067519 mRNA. Translation: BAB67825.1. Different initiation.
AL834532 mRNA. Translation: CAD39188.2.
CU467002 Genomic DNA. Translation: CAQ08955.1.
CU207370 Genomic DNA. Translation: CAQ52433.1.
CH471135 Genomic DNA. Translation: EAW72248.1.
BC028048 mRNA. Translation: AAH28048.1.
CCDSiCCDS12894.1. [Q96PV6-2]
RefSeqiNP_443157.1. NM_052925.3. [Q96PV6-2]
XP_005258543.1. XM_005258486.3. [Q96PV6-2]
XP_005277301.1. XM_005277244.3. [Q96PV6-2]
XP_011524717.1. XM_011526415.1. [Q96PV6-2]
XP_011545403.1. XM_011547101.1. [Q96PV6-2]
UniGeneiHs.502378.
Hs.744596.

3D structure databases

ProteinModelPortaliQ96PV6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125373. 35 interactions.
IntActiQ96PV6. 29 interactions.
MINTiMINT-1435849.

PTM databases

iPTMnetiQ96PV6.
PhosphoSiteiQ96PV6.

Polymorphism and mutation databases

BioMutaiLENG8.
DMDMi158705886.

Proteomic databases

EPDiQ96PV6.
MaxQBiQ96PV6.
PeptideAtlasiQ96PV6.
PRIDEiQ96PV6.

Protocols and materials databases

DNASUi114823.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000326764; ENSP00000318374; ENSG00000167615. [Q96PV6-2]
ENST00000617180; ENSP00000480663; ENSG00000276681. [Q96PV6-2]
ENST00000621306; ENSP00000478337; ENSG00000276458. [Q96PV6-2]
ENST00000622672; ENSP00000478975; ENSG00000274305. [Q96PV6-2]
GeneIDi114823.
KEGGihsa:114823.
UCSCiuc032iea.2. human. [Q96PV6-1]

Organism-specific databases

CTDi114823.
GeneCardsiLENG8.
HGNCiHGNC:15500. LENG8.
HPAiHPA042004.
HPA042056.
HPA061571.
MIMi616575. gene.
neXtProtiNX_Q96PV6.
PharmGKBiPA134903953.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000008006.
HOGENOMiHOG000001575.
HOVERGENiHBG070702.
InParanoidiQ96PV6.
OMAiVITNAIM.
PhylomeDBiQ96PV6.
TreeFamiTF312927.

Miscellaneous databases

ChiTaRSiLENG8. human.
GenomeRNAii114823.
PROiQ96PV6.
SOURCEiSearch...

Gene expression databases

BgeeiQ96PV6.
CleanExiHS_LENG8.
ExpressionAtlasiQ96PV6. baseline and differential.
GenevisibleiQ96PV6. HS.

Family and domain databases

InterProiIPR005062. SAC3/GANP/THP3.
[Graphical view]
PfamiPF03399. SAC3_GANP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins."
    Nagase T., Kikuno R., Ohara O.
    DNA Res. 8:179-187(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Testis.
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Uterus.
  6. "Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II."
    Baillat D., Hakimi M.-A., Naeaer A.M., Shilatifard A., Cooch N., Shiekhattar R.
    Cell 123:265-276(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN COMPLEX WITH SHFM1, IDENTIFICATION BY MASS SPECTROMETRY.
  7. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS], IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-314, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma and Erythroleukemia.

Entry informationi

Entry nameiLENG8_HUMAN
AccessioniPrimary (citable) accession number: Q96PV6
Secondary accession number(s): B0VJY9, Q8IZ27, Q8NCX6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: July 6, 2016
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.