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Protein

Leukocyte receptor cluster member 8

Gene

LENG8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Leukocyte receptor cluster member 8
Gene namesi
Name:LENG8
Synonyms:KIAA1932
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:15500. LENG8.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000167615.
ENSG00000274305.
ENSG00000276458.
ENSG00000276681.
PharmGKBiPA134903953.

Polymorphism and mutation databases

BioMutaiLENG8.
DMDMi158705886.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00003063912 – 779Leukocyte receptor cluster member 8Add BLAST778

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei314PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ96PV6.
PeptideAtlasiQ96PV6.
PRIDEiQ96PV6.

PTM databases

iPTMnetiQ96PV6.
PhosphoSitePlusiQ96PV6.

Expressioni

Gene expression databases

BgeeiENSG00000167615.
CleanExiHS_LENG8.
ExpressionAtlasiQ96PV6. baseline and differential.
GenevisibleiQ96PV6. HS.

Organism-specific databases

HPAiHPA042004.
HPA042056.
HPA061571.

Interactioni

Subunit structurei

May be part of a SHFM1-containing complex.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CEP70Q8NHQ13EBI-739546,EBI-739624
SNRPAP090123EBI-739546,EBI-607085

Protein-protein interaction databases

BioGridi125373. 35 interactors.
IntActiQ96PV6. 46 interactors.
MINTiMINT-1435849.

Structurei

3D structure databases

ProteinModelPortaliQ96PV6.
SMRiQ96PV6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi82 – 85Poly-Gln4
Compositional biasi86 – 103Tyr-richAdd BLAST18
Compositional biasi375 – 409Ser-richAdd BLAST35

Phylogenomic databases

GeneTreeiENSGT00390000008006.
HOGENOMiHOG000001575.
HOVERGENiHBG070702.
InParanoidiQ96PV6.
OMAiKAQNHRG.
OrthoDBiEOG091G08LT.
PhylomeDBiQ96PV6.
TreeFamiTF312927.

Family and domain databases

InterProiIPR005062. SAC3/GANP/THP3.
[Graphical view]
PfamiPF03399. SAC3_GANP. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96PV6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAANVGDQRS TDWSSQYSMV AGAGRENGME TPMHENPEWE KARQALASIS
60 70 80 90 100
KSGAAGGSAK SSSNGPVASA QYVSQAEASA LQQQQYYQWY QQYNYAYPYS
110 120 130 140 150
YYYPMPPVPG MDESMSYQAP PQQLPSAQPP QPSNPPHGAH TLNSGPQPGT
160 170 180 190 200
APATQHSQAG PATGQAYGPH TYTEPAKPKK GQQLWNRMKP APGTGGLKFN
210 220 230 240 250
IQKRPFAVTT QSFGSNAEGQ HSGFGPQPNP EKVQNHSGSS ARGNLSGKPD
260 270 280 290 300
DWPQDMKEYV ERCFTACESE EDKDRTEKLL KEVLQARLQD GSAYTIDWSR
310 320 330 340 350
EPLPGLTREP VAESPKKKRW EAASSLHPPR GAGSATRGGG APSQRGTPGA
360 370 380 390 400
GGAGRARGNS FTKFGNRNVF MKDNSSSSST DSRSRSSSRS PTRHFRRSDS
410 420 430 440 450
HSDSDSSYSG NECHPVGRRN PPPKGRGGRG AHMDRGRGRA QRGKRHDLAP
460 470 480 490 500
TKRSRKKMAA LECEDPEREL KKQKRAARFQ HGHSRRLRLE PLVLQMSSLE
510 520 530 540 550
SSGADPDWQE LQIVGTCPDI TKHYLRLTCA PDPSTVRPVA VLKKSLCMVK
560 570 580 590 600
CHWKEKQDYA FACEQMKSIR QDLTVQGIRT EFTVEVYETH ARIALEKGDH
610 620 630 640 650
EEFNQCQTQL KSLYAENLPG NVGEFTAYRI LYYIFTKNSG DITTELAYLT
660 670 680 690 700
RELKADPCVA HALALRTAWA LGNYHRFFRL YCHAPCMSGY LVDKFADRER
710 720 730 740 750
KVALKAMIKT YVVPSSLLPL LFPSFRLVSS CIKLSPCPLL PLPPVFLLIF
760 770
FSPFPPSLSA FFPWFSTGKT VPLPPSSAM
Length:779
Mass (Da):86,129
Last modified:October 2, 2007 - v2
Checksum:i7001D773F93486A6
GO
Isoform 2 (identifier: Q96PV6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     105-105: M → MSMYQSYGSPSQYGMAGSYGSATPQQPSAPQHQGTLNQ
     711-779: YVVPSSLLPL...TVPLPPSSAM → FRPALPVSYL...RLSLAQLSAF

Show »
Length:800
Mass (Da):88,157
Checksum:iDCD37905D54D1544
GO
Isoform 3 (identifier: Q96PV6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     38-54: EWEKARQALASISKSGA → DNSSIDCRLSLAQLSAF
     55-779: Missing.

Show »
Length:54
Mass (Da):5,835
Checksum:i53D37F914A53FF36
GO

Sequence cautioni

The sequence BAB67825 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035294242R → P.Corresponds to variant rs35061854dbSNPEnsembl.1
Natural variantiVAR_035295520I → V.Corresponds to variant rs35336528dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02846038 – 54EWEKA…SKSGA → DNSSIDCRLSLAQLSAF in isoform 3. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_02846155 – 779Missing in isoform 3. 1 PublicationAdd BLAST725
Alternative sequenceiVSP_028462105M → MSMYQSYGSPSQYGMAGSYG SATPQQPSAPQHQGTLNQ in isoform 2. 1 Publication1
Alternative sequenceiVSP_028463711 – 779YVVPS…PSSAM → FRPALPVSYLQAELAFEGEA ACRAFLEPLGLAYTGPDNSS IDCRLSLAQLSAF in isoform 2. 1 PublicationAdd BLAST69

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB067519 mRNA. Translation: BAB67825.1. Different initiation.
AL834532 mRNA. Translation: CAD39188.2.
CU467002 Genomic DNA. Translation: CAQ08955.1.
CU207370 Genomic DNA. Translation: CAQ52433.1.
CH471135 Genomic DNA. Translation: EAW72248.1.
BC028048 mRNA. Translation: AAH28048.1.
CCDSiCCDS12894.1. [Q96PV6-2]
RefSeqiNP_443157.1. NM_052925.3. [Q96PV6-2]
XP_011524717.1. XM_011526415.2. [Q96PV6-2]
UniGeneiHs.502378.
Hs.744596.

Genome annotation databases

EnsembliENST00000326764; ENSP00000318374; ENSG00000167615. [Q96PV6-2]
ENST00000617180; ENSP00000480663; ENSG00000276681. [Q96PV6-2]
ENST00000621306; ENSP00000478337; ENSG00000276458. [Q96PV6-2]
ENST00000622672; ENSP00000478975; ENSG00000274305. [Q96PV6-2]
GeneIDi114823.
KEGGihsa:114823.
UCSCiuc032iea.2. human. [Q96PV6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB067519 mRNA. Translation: BAB67825.1. Different initiation.
AL834532 mRNA. Translation: CAD39188.2.
CU467002 Genomic DNA. Translation: CAQ08955.1.
CU207370 Genomic DNA. Translation: CAQ52433.1.
CH471135 Genomic DNA. Translation: EAW72248.1.
BC028048 mRNA. Translation: AAH28048.1.
CCDSiCCDS12894.1. [Q96PV6-2]
RefSeqiNP_443157.1. NM_052925.3. [Q96PV6-2]
XP_011524717.1. XM_011526415.2. [Q96PV6-2]
UniGeneiHs.502378.
Hs.744596.

3D structure databases

ProteinModelPortaliQ96PV6.
SMRiQ96PV6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125373. 35 interactors.
IntActiQ96PV6. 46 interactors.
MINTiMINT-1435849.

PTM databases

iPTMnetiQ96PV6.
PhosphoSitePlusiQ96PV6.

Polymorphism and mutation databases

BioMutaiLENG8.
DMDMi158705886.

Proteomic databases

MaxQBiQ96PV6.
PeptideAtlasiQ96PV6.
PRIDEiQ96PV6.

Protocols and materials databases

DNASUi114823.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000326764; ENSP00000318374; ENSG00000167615. [Q96PV6-2]
ENST00000617180; ENSP00000480663; ENSG00000276681. [Q96PV6-2]
ENST00000621306; ENSP00000478337; ENSG00000276458. [Q96PV6-2]
ENST00000622672; ENSP00000478975; ENSG00000274305. [Q96PV6-2]
GeneIDi114823.
KEGGihsa:114823.
UCSCiuc032iea.2. human. [Q96PV6-1]

Organism-specific databases

CTDi114823.
GeneCardsiLENG8.
HGNCiHGNC:15500. LENG8.
HPAiHPA042004.
HPA042056.
HPA061571.
MIMi616575. gene.
neXtProtiNX_Q96PV6.
OpenTargetsiENSG00000167615.
ENSG00000274305.
ENSG00000276458.
ENSG00000276681.
PharmGKBiPA134903953.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000008006.
HOGENOMiHOG000001575.
HOVERGENiHBG070702.
InParanoidiQ96PV6.
OMAiKAQNHRG.
OrthoDBiEOG091G08LT.
PhylomeDBiQ96PV6.
TreeFamiTF312927.

Miscellaneous databases

ChiTaRSiLENG8. human.
GenomeRNAii114823.
PROiQ96PV6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000167615.
CleanExiHS_LENG8.
ExpressionAtlasiQ96PV6. baseline and differential.
GenevisibleiQ96PV6. HS.

Family and domain databases

InterProiIPR005062. SAC3/GANP/THP3.
[Graphical view]
PfamiPF03399. SAC3_GANP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLENG8_HUMAN
AccessioniPrimary (citable) accession number: Q96PV6
Secondary accession number(s): B0VJY9, Q8IZ27, Q8NCX6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: November 30, 2016
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.