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Protein

Paraneoplastic antigen-like protein 5

Gene

PNMA5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • identical protein binding Source: IntAct

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Paraneoplastic antigen-like protein 5
Alternative name(s):
Tumor antigen BJ-HCC-25
Gene namesi
Name:PNMA5
Synonyms:KIAA1934
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000198883.11
HGNCiHGNC:18743 PNMA5
MIMi300916 gene
neXtProtiNX_Q96PV4

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198883
PharmGKBiPA38668

Polymorphism and mutation databases

BioMutaiPNMA5
DMDMi160419235

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003112171 – 448Paraneoplastic antigen-like protein 5Add BLAST448

Proteomic databases

PaxDbiQ96PV4
PeptideAtlasiQ96PV4
PRIDEiQ96PV4

PTM databases

iPTMnetiQ96PV4
PhosphoSitePlusiQ96PV4

Expressioni

Tissue specificityi

Expressed in the brain.1 Publication

Gene expression databases

BgeeiENSG00000198883
CleanExiHS_PNMA5
ExpressionAtlasiQ96PV4 baseline and differential

Organism-specific databases

HPAiHPA044690

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi12537438 interactors.
IntActiQ96PV4 59 interactors.
STRINGi9606.ENSP00000354834

Structurei

3D structure databases

ProteinModelPortaliQ96PV4
SMRiQ96PV4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PNMA family.Curated

Phylogenomic databases

eggNOGiENOG410JBGG Eukaryota
ENOG4111E9E LUCA
GeneTreeiENSGT00530000062986
HOGENOMiHOG000013079
HOVERGENiHBG052488
InParanoidiQ96PV4
OMAiGAMSHPK
OrthoDBiEOG091G0BG9
PhylomeDBiQ96PV4
TreeFamiTF335054

Family and domain databases

InterProiView protein in InterPro
IPR026523 PNMA
IPR026527 PNMA5
PANTHERiPTHR23095 PTHR23095, 1 hit
PTHR23095:SF4 PTHR23095:SF4, 1 hit
PfamiView protein in Pfam
PF14893 PNMA, 1 hit

Sequencei

Sequence statusi: Complete.

Q96PV4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALTLLEDWC KGMDMDPRKA LLIVGIPMEC SEVEIQDTVK AGLQPLCAYR
60 70 80 90 100
VLGRMFRRED NAKAVFIELA DTVNYTTLPS HIPGKGGSWE VVVKPRNPDD
110 120 130 140 150
EFLSRLNYFL KDEGRSMTDV ARALGCCSLP AESLDAEVMP QVRSPPLEPP
160 170 180 190 200
KESMWYRKLK VFSGTASPSP GEETFEDWLE QVTEIMPIWQ VSEVEKRRRL
210 220 230 240 250
LESLRGPALS IMRVLQANND SITVEQCLDA LKQIFGDKED FRASQFRFLQ
260 270 280 290 300
TSPKIGEKVS TFLLRLEPLL QKAVHKSPLS VRSTDMIRLK HLLARVAMTP
310 320 330 340 350
ALRGKLELLD QRGCPPNFLE LMKLIRDEEE WENTEAVMKN KEKPSGRGRG
360 370 380 390 400
ASGRQARAEA SVSAPQATVQ ARSFSDSSPQ TIQGGLPPLV KRRRLLGSES
410 420 430 440
TRGEDHGQAT YPKAENQTPG REGPQAAGEE LGNEAGAGAM SHPKPWET
Length:448
Mass (Da):49,934
Last modified:November 13, 2007 - v2
Checksum:i5F6BC8A15B457A89
GO

Sequence cautioni

The sequence BAB67827 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti242R → G in AAI01113 (PubMed:15489334).Curated1
Sequence conflicti325I → T in BAH14475 (PubMed:14702039).Curated1
Sequence conflicti359E → G in BAH14475 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037164107N → H. Corresponds to variant dbSNP:rs3810655Ensembl.1
Natural variantiVAR_037165349R → W. Corresponds to variant dbSNP:rs3810654Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY121806 mRNA Translation: AAM82754.1
AB067521 mRNA Translation: BAB67827.1 Different initiation.
AK295446 mRNA Translation: BAG58384.1
AK316104 mRNA Translation: BAH14475.1
CH471172 Genomic DNA Translation: EAW72892.1
BC101111 mRNA Translation: AAI01112.1
BC101112 mRNA Translation: AAI01113.1
BC101113 mRNA Translation: AAI01114.1
CCDSiCCDS14718.1
RefSeqiNP_001096620.1, NM_001103150.1
NP_001096621.1, NM_001103151.1
NP_001171853.1, NM_001184924.1
NP_443158.1, NM_052926.2
XP_016884741.1, XM_017029252.1
XP_016884742.1, XM_017029253.1
UniGeneiHs.573567

Genome annotation databases

EnsembliENST00000361887; ENSP00000354834; ENSG00000198883
ENST00000439251; ENSP00000388850; ENSG00000198883
ENST00000452693; ENSP00000392342; ENSG00000198883
ENST00000535214; ENSP00000445775; ENSG00000198883
GeneIDi114824
KEGGihsa:114824
UCSCiuc004fgy.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPNMA5_HUMAN
AccessioniPrimary (citable) accession number: Q96PV4
Secondary accession number(s): B4DI72
, B7Z9Y9, Q495L5, Q8NET3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: April 25, 2018
This is version 100 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome