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Protein

Paraneoplastic antigen-like protein 5

Gene

PNMA5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • identical protein binding Source: IntAct

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Paraneoplastic antigen-like protein 5
Alternative name(s):
Tumor antigen BJ-HCC-25
Gene namesi
Name:PNMA5
Synonyms:KIAA1934
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:18743. PNMA5.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198883.
PharmGKBiPA38668.

Polymorphism and mutation databases

BioMutaiPNMA5.
DMDMi160419235.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003112171 – 448Paraneoplastic antigen-like protein 5Add BLAST448

Proteomic databases

PaxDbiQ96PV4.
PeptideAtlasiQ96PV4.
PRIDEiQ96PV4.

PTM databases

iPTMnetiQ96PV4.
PhosphoSitePlusiQ96PV4.

Expressioni

Tissue specificityi

Expressed in the brain.1 Publication

Gene expression databases

BgeeiENSG00000198883.
CleanExiHS_PNMA5.
ExpressionAtlasiQ96PV4. baseline and differential.

Organism-specific databases

HPAiHPA044690.

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi125374. 37 interactors.
IntActiQ96PV4. 60 interactors.
STRINGi9606.ENSP00000354834.

Structurei

3D structure databases

ProteinModelPortaliQ96PV4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PNMA family.Curated

Phylogenomic databases

eggNOGiENOG410JBGG. Eukaryota.
ENOG4111E9E. LUCA.
GeneTreeiENSGT00530000062986.
HOGENOMiHOG000013079.
HOVERGENiHBG052488.
InParanoidiQ96PV4.
OMAiGAMSHPK.
OrthoDBiEOG091G0BG9.
PhylomeDBiQ96PV4.
TreeFamiTF335054.

Family and domain databases

InterProiView protein in InterPro
IPR026523. PNMA.
IPR026527. PNMA5.
PANTHERiPTHR23095. PTHR23095. 1 hit.
PTHR23095:SF32. PTHR23095:SF32. 1 hit.
PfamiView protein in Pfam
PF14893. PNMA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96PV4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALTLLEDWC KGMDMDPRKA LLIVGIPMEC SEVEIQDTVK AGLQPLCAYR
60 70 80 90 100
VLGRMFRRED NAKAVFIELA DTVNYTTLPS HIPGKGGSWE VVVKPRNPDD
110 120 130 140 150
EFLSRLNYFL KDEGRSMTDV ARALGCCSLP AESLDAEVMP QVRSPPLEPP
160 170 180 190 200
KESMWYRKLK VFSGTASPSP GEETFEDWLE QVTEIMPIWQ VSEVEKRRRL
210 220 230 240 250
LESLRGPALS IMRVLQANND SITVEQCLDA LKQIFGDKED FRASQFRFLQ
260 270 280 290 300
TSPKIGEKVS TFLLRLEPLL QKAVHKSPLS VRSTDMIRLK HLLARVAMTP
310 320 330 340 350
ALRGKLELLD QRGCPPNFLE LMKLIRDEEE WENTEAVMKN KEKPSGRGRG
360 370 380 390 400
ASGRQARAEA SVSAPQATVQ ARSFSDSSPQ TIQGGLPPLV KRRRLLGSES
410 420 430 440
TRGEDHGQAT YPKAENQTPG REGPQAAGEE LGNEAGAGAM SHPKPWET
Length:448
Mass (Da):49,934
Last modified:November 13, 2007 - v2
Checksum:i5F6BC8A15B457A89
GO

Sequence cautioni

The sequence BAB67827 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti242R → G in AAI01113 (PubMed:15489334).Curated1
Sequence conflicti325I → T in BAH14475 (PubMed:14702039).Curated1
Sequence conflicti359E → G in BAH14475 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037164107N → H. Corresponds to variant dbSNP:rs3810655Ensembl.1
Natural variantiVAR_037165349R → W. Corresponds to variant dbSNP:rs3810654Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY121806 mRNA. Translation: AAM82754.1.
AB067521 mRNA. Translation: BAB67827.1. Different initiation.
AK295446 mRNA. Translation: BAG58384.1.
AK316104 mRNA. Translation: BAH14475.1.
CH471172 Genomic DNA. Translation: EAW72892.1.
BC101111 mRNA. Translation: AAI01112.1.
BC101112 mRNA. Translation: AAI01113.1.
BC101113 mRNA. Translation: AAI01114.1.
CCDSiCCDS14718.1.
RefSeqiNP_001096620.1. NM_001103150.1.
NP_001096621.1. NM_001103151.1.
NP_001171853.1. NM_001184924.1.
NP_443158.1. NM_052926.2.
XP_016884741.1. XM_017029252.1.
XP_016884742.1. XM_017029253.1.
UniGeneiHs.573567.

Genome annotation databases

EnsembliENST00000361887; ENSP00000354834; ENSG00000198883.
ENST00000439251; ENSP00000388850; ENSG00000198883.
ENST00000452693; ENSP00000392342; ENSG00000198883.
ENST00000535214; ENSP00000445775; ENSG00000198883.
GeneIDi114824.
KEGGihsa:114824.
UCSCiuc004fgy.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiPNMA5_HUMAN
AccessioniPrimary (citable) accession number: Q96PV4
Secondary accession number(s): B4DI72
, B7Z9Y9, Q495L5, Q8NET3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: July 5, 2017
This is version 94 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families