Q96PU9 (ODF3A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Outer dense fiber protein 3

Alternative name(s):
Outer dense fiber of sperm tails protein 3
Sperm tail protein SHIPPO 1
Transcript induced in spermiogenesis protein 50

Gene names

Name:	ODF3
Synonyms:	SHIPPO1, TISP50

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	254 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Outer dense fibers are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail. May help to maintain the passive elastic structures and elastic recoil of the sperm tail.
Subcellular location	Cytoplasm By similarity. Note: Expressed in the cytoplasmic lobe of spermatids By similarity.
Tissue specificity	Testis-specific. Ref.1 Ref.2
Miscellaneous	'Shippo' is a Japanese word for tail.
Sequence similarities	Belongs to the ODF3 family. Contains 2 DUF1309 repeats.

Ontologies

Keywords
Biological process	Differentiation Spermatogenesis
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing
Domain	Repeat
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW spermatogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96PU9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96PU9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     104-138: GDYFPEKSTKYVFDSAPSHSISARTKAFRVDSTPG → ALKSAFPSWTPRDPTWSPPVLEPRGPTPRMLGSPP
     139-254: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 254	254	Outer dense fiber protein 3		PRO_0000299464
Regions
	Repeat	180 – 205	26	DUF1309 1
	Repeat	216 – 241	26	DUF1309 2
Natural variations
	Alternative sequence	104 – 138	35	GDYFP…DSTPG → ALKSAFPSWTPRDPTWSPPV LEPRGPTPRMLGSPP in isoform 2.		VSP_027686
	Alternative sequence	139 – 254	116	Missing in isoform 2.		VSP_027687

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 549AA2DEA35201E5	FASTA	254	27,710
	10 20 30 40 50 60 MTEEVWMGTW RPHRPRGPIM ALYSSPGPKY LIPPTTGFMK HTPTKLRAPA YSFRGAPMLL 70 80 90 100 110 120 AENCSPGPRY NVNPKILRTG KDLGPAYSIL GRYQTKTMLT PGPGDYFPEK STKYVFDSAP 130 140 150 160 170 180 SHSISARTKA FRVDSTPGPA AYMLPMVMGP NTVGKASQPS FSIKGRSKLG GFSDDLHKTP 190 200 210 220 230 240 GPAAYRQTDV RVTKFKAPQY TMAARVEPPG DKTLKPGPGA HSPEKVTLTK PCAPVVTFGI 250 KHSDYMTPLL VDVE
	Isoform 2 [UniParc]. Checksum: AE324753BD2EA4B1	FASTA	138	15,296
	10 20 30 40 50 60 MTEEVWMGTW RPHRPRGPIM ALYSSPGPKY LIPPTTGFMK HTPTKLRAPA YSFRGAPMLL 70 80 90 100 110 120 AENCSPGPRY NVNPKILRTG KDLGPAYSIL GRYQTKTMLT PGPALKSAFP SWTPRDPTWS 130 PPVLEPRGPT PRMLGSPP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and characterization of a complementary DNA encoding sperm tail protein SHIPPO 1." Egydio de Carvalho C., Tanaka H., Iguchi N., Ventela S., Nojima H., Nishimune Y. Biol. Reprod. 66:785-795(2002) [PubMed: 11870087] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY. Tissue: Testis.
[2]	"The human transcript induced in spermatogenesis 50." Sasaki Y., Miyamoto T., Sengoku K., Hayashi H., Takuma N., Ishikawa M. Reprod. Med. Biol. 3:237-243(2004) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Testis.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB067774 mRNA. Translation: BAB70734.1. AY713299 mRNA. Translation: AAW83203.1. AL133658 mRNA. Translation: CAH10709.1. BC126222 mRNA. Translation: AAI26223.1. BC126248 mRNA. Translation: AAI26249.1.
IPI	IPI00102524. IPI00743900.
RefSeq	NP_444510.2. NM_053280.3.
UniGene	Hs.350949.
3D structure databases
ProteinModelPortal	Q96PU9.
ModBase	Search...
Protein-protein interaction databases
STRING	Q96PU9.
PTM databases
PhosphoSite	Q96PU9.
Polymorphism databases
DMDM	74717117.
Proteomic databases
PRIDE	Q96PU9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000325113; ENSP00000325868; ENSG00000177947.
GeneID	113746.
KEGG	hsa:113746.
UCSC	uc001lob.1. human. uc001loc.2. human.
Organism-specific databases
CTD	113746.
GeneCards	GC11P000196.
H-InvDB	HIX0022850.
HGNC	HGNC:19905. ODF3.
HPA	HPA039241.
MIM	608356. gene.
neXtProt	NX_Q96PU9.
PharmGKB	PA134952791.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG17873.
GeneTree	ENSGT00440000039820.
HOGENOM	HBG445401.
HOVERGEN	HBG054464.
InParanoid	Q96PU9.
OMA	FDSAPSH.
OrthoDB	EOG4QC165.
PhylomeDB	Q96PU9.
Gene expression databases
ArrayExpress	Q96PU9.
Bgee	Q96PU9.
CleanEx	HS_ODF3.
Genevestigator	Q96PU9.
Family and domain databases
InterPro	IPR010736. DUF1309. [Graphical view]
Pfam	PF07004. DUF1309. 2 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	78898.
SOURCE	Search...

Entry information

Entry name

ODF3A_HUMAN

Accession

Primary (citable) accession number: Q96PU9
Secondary accession number(s): Q69YX0

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	December 1, 2001
Last modified:	January 25, 2012
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.