Q96PU8 (QKI_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein quaking
Short name=Hqk
Short name=HqkI

Gene names

Name:	QKI
Synonyms:	HKQ

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	341 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B. Regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor By similarity. Ref.9
Subunit structure	Homodimer. Does not require RNA to homodimerize. Able to heterodimerize with BICC1 By similarity.
Subcellular location	Nucleus By similarity. Cytoplasm By similarity.
Tissue specificity	Expressed in the frontal cortex of brain. Down-regulated in the brain of schizophrenic patients. Ref.8
Post-translational modification	Methylated by PRMT1 By similarity. Ref.7 Ref.11 Tyrosine phosphorylated at its C-terminus, probably by FYN. Phosphorylation leads to decreased mRNA-binding affinity, affecting transport and/or stabilization of MBP mRNA By similarity.
Sequence similarities	Contains 1 KH domain.
Sequence caution	The sequence AAF63412.1 differs from that shown. Reason: Chimeric cDNA. The sequence AAF63413.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence AAF63413.1 differs from that shown. Reason: Cloning artifact in N-terminus. The sequence AAF63414.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence AAF63414.1 differs from that shown. Reason: Cloning artifact in N-terminus. The sequence AAF63415.1 differs from that shown. Reason: Chimeric cDNA. The sequence AAF63416.1 differs from that shown. Reason: Chimeric cDNA. The sequence AAF63417.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence AAF63417.1 differs from that shown. Reason: Cloning artifact in N-terminus. The sequence BAB55032.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Biological process	Differentiation Translation regulation Transport mRNA processing mRNA splicing mRNA transport
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	SH3-binding
Ligand	RNA-binding
Molecular function	Developmental protein
PTM	Methylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	RNA splicing Inferred from electronic annotation. Source: UniProtKB-KW long-chain fatty acid biosynthetic process Inferred from electronic annotation. Source: Compara mRNA processing Inferred from electronic annotation. Source: UniProtKB-KW mRNA transport Inferred from electronic annotation. Source: UniProtKB-KW muscle cell differentiation Inferred from electronic annotation. Source: Compara myelination Inferred from electronic annotation. Source: Compara positive regulation of gene expression Inferred from electronic annotation. Source: Compara regulation of translation Inferred from electronic annotation. Source: UniProtKB-KW spermatid development Inferred from electronic annotation. Source: Compara vasculogenesis Inferred from electronic annotation. Source: Compara
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
HNRNPK	P61978	3	EBI-945792,EBI-304185
PCBP1	Q15365	2	EBI-945792,EBI-946095
PTBP1	P26599	2	EBI-945792,EBI-350540
RBFOX1	Q9NWB1	2	EBI-945792,EBI-945906
RBFOX2	O43251	2	EBI-945792,EBI-746056
RBPMS	Q93062	2	EBI-945792,EBI-740322

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96PU8-1)

Also known as: HQK-5; QKI-5;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96PU8-3)

The sequence of this isoform differs from the canonical sequence as follows:
     213-220: Missing.

Isoform 3 (identifier: Q96PU8-5)

The sequence of this isoform differs from the canonical sequence as follows:
     213-220: Missing.
     312-341: GAVATKVRRHDMRVHPYQRIVTADRAATGN → EWIEMPVMPDISAH

Isoform 4 (identifier: Q96PU8-6)

Also known as: HQK-7;

The sequence of this isoform differs from the canonical sequence as follows:
     312-341: GAVATKVRRHDMRVHPYQRIVTADRAATGN → EWIEMPVMPDISAH

Isoform 5 (identifier: Q96PU8-8)

Also known as: HQK-7B;

The sequence of this isoform differs from the canonical sequence as follows:
     312-341: GAVATKVRRHDMRVHPYQRIVTADRAATGN → GKFFSPWG

Isoform 6 (identifier: Q96PU8-9)

The sequence of this isoform differs from the canonical sequence as follows:
     312-341: GAVATKVRRHDMRVHPYQRIVTADRAATGN → GMAFPTKG

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 341	341	Protein quaking		PRO_0000239373
Regions
	Domain	87 – 153	67	KH
	Motif	276 – 279	4	SH3-binding
	Motif	324 – 330	7	Nuclear localization signal By similarity
Amino acid modifications
	Modified residue	242	1	Asymmetric dimethylarginine; by CARM1 Ref.11
Natural variations
	Alternative sequence	213 – 220	8	Missing in isoform 2 and isoform 3.		VSP_019188
	Alternative sequence	312 – 341	30	GAVAT…AATGN → EWIEMPVMPDISAH in isoform 3 and isoform 4.		VSP_019190
	Alternative sequence	312 – 341	30	GAVAT…AATGN → GKFFSPWG in isoform 5.		VSP_019191
	Alternative sequence	312 – 341	30	GAVAT…AATGN → GMAFPTKG in isoform 6.		VSP_019189
	Natural variant	336	1	R → Q in a colorectal cancer sample; somatic mutation. Ref.12		VAR_036051
Experimental info
	Sequence conflict	30	1	S → G in ABC88600. Ref.3
	Sequence conflict	208	1	N → D in AAH12222. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (HQK-5) (QKI-5) [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 43E7F3A426A494C4	FASTA	341	37,671
	10 20 30 40 50 60 MVGEMETKEK PKPTPDYLMQ LMNDKKLMSS LPNFCGIFNH LERLLDEEIS RVRKDMYNDT 70 80 90 100 110 120 LNGSTEKRSA ELPDAVGPIV QLQEKLYVPV KEYPDFNFVG RILGPRGLTA KQLEAETGCK 130 140 150 160 170 180 IMVRGKGSMR DKKKEEQNRG KPNWEHLNED LHVLITVEDA QNRAEIKLKR AVEEVKKLLV 190 200 210 220 230 240 PAAEGEDSLK KMQLMELAIL NGTYRDANIK SPALAFSLAA TAQAAPRIIT GPAPVLPPAA 250 260 270 280 290 300 LRTPTPAGPT IMPLIRQIQT AVMPNGTPHP TAAIVPPGPE AGLIYTPYEY PYTLAPATSI 310 320 330 340 LEYPIEPSGV LGAVATKVRR HDMRVHPYQR IVTADRAATG N
	Isoform 2 [UniParc]. Checksum: 920353FF3C2B7403	FASTA	333	36,926
	10 20 30 40 50 60 MVGEMETKEK PKPTPDYLMQ LMNDKKLMSS LPNFCGIFNH LERLLDEEIS RVRKDMYNDT 70 80 90 100 110 120 LNGSTEKRSA ELPDAVGPIV QLQEKLYVPV KEYPDFNFVG RILGPRGLTA KQLEAETGCK 130 140 150 160 170 180 IMVRGKGSMR DKKKEEQNRG KPNWEHLNED LHVLITVEDA QNRAEIKLKR AVEEVKKLLV 190 200 210 220 230 240 PAAEGEDSLK KMQLMELAIL NGTYRDANIK SPTAQAAPRI ITGPAPVLPP AALRTPTPAG 250 260 270 280 290 300 PTIMPLIRQI QTAVMPNGTP HPTAAIVPPG PEAGLIYTPY EYPYTLAPAT SILEYPIEPS 310 320 330 GVLGAVATKV RRHDMRVHPY QRIVTADRAA TGN
	Isoform 3 [UniParc]. Checksum: DB23E1D2573820DF	FASTA	317	35,233
	10 20 30 40 50 60 MVGEMETKEK PKPTPDYLMQ LMNDKKLMSS LPNFCGIFNH LERLLDEEIS RVRKDMYNDT 70 80 90 100 110 120 LNGSTEKRSA ELPDAVGPIV QLQEKLYVPV KEYPDFNFVG RILGPRGLTA KQLEAETGCK 130 140 150 160 170 180 IMVRGKGSMR DKKKEEQNRG KPNWEHLNED LHVLITVEDA QNRAEIKLKR AVEEVKKLLV 190 200 210 220 230 240 PAAEGEDSLK KMQLMELAIL NGTYRDANIK SPTAQAAPRI ITGPAPVLPP AALRTPTPAG 250 260 270 280 290 300 PTIMPLIRQI QTAVMPNGTP HPTAAIVPPG PEAGLIYTPY EYPYTLAPAT SILEYPIEPS 310 GVLEWIEMPV MPDISAH
	Isoform 4 (HQK-7) [UniParc]. Checksum: B4B2DA898F0145B3	FASTA	325	35,978
	10 20 30 40 50 60 MVGEMETKEK PKPTPDYLMQ LMNDKKLMSS LPNFCGIFNH LERLLDEEIS RVRKDMYNDT 70 80 90 100 110 120 LNGSTEKRSA ELPDAVGPIV QLQEKLYVPV KEYPDFNFVG RILGPRGLTA KQLEAETGCK 130 140 150 160 170 180 IMVRGKGSMR DKKKEEQNRG KPNWEHLNED LHVLITVEDA QNRAEIKLKR AVEEVKKLLV 190 200 210 220 230 240 PAAEGEDSLK KMQLMELAIL NGTYRDANIK SPALAFSLAA TAQAAPRIIT GPAPVLPPAA 250 260 270 280 290 300 LRTPTPAGPT IMPLIRQIQT AVMPNGTPHP TAAIVPPGPE AGLIYTPYEY PYTLAPATSI 310 320 LEYPIEPSGV LEWIEMPVMP DISAH
	Isoform 5 (HQK-7B) [UniParc]. Checksum: D152389660BB4147	FASTA	319	35,248
	10 20 30 40 50 60 MVGEMETKEK PKPTPDYLMQ LMNDKKLMSS LPNFCGIFNH LERLLDEEIS RVRKDMYNDT 70 80 90 100 110 120 LNGSTEKRSA ELPDAVGPIV QLQEKLYVPV KEYPDFNFVG RILGPRGLTA KQLEAETGCK 130 140 150 160 170 180 IMVRGKGSMR DKKKEEQNRG KPNWEHLNED LHVLITVEDA QNRAEIKLKR AVEEVKKLLV 190 200 210 220 230 240 PAAEGEDSLK KMQLMELAIL NGTYRDANIK SPALAFSLAA TAQAAPRIIT GPAPVLPPAA 250 260 270 280 290 300 LRTPTPAGPT IMPLIRQIQT AVMPNGTPHP TAAIVPPGPE AGLIYTPYEY PYTLAPATSI 310 LEYPIEPSGV LGKFFSPWG
	Isoform 6 [UniParc]. Checksum: D1427E54B0BF54E7	FASTA	319	35,131
	10 20 30 40 50 60 MVGEMETKEK PKPTPDYLMQ LMNDKKLMSS LPNFCGIFNH LERLLDEEIS RVRKDMYNDT 70 80 90 100 110 120 LNGSTEKRSA ELPDAVGPIV QLQEKLYVPV KEYPDFNFVG RILGPRGLTA KQLEAETGCK 130 140 150 160 170 180 IMVRGKGSMR DKKKEEQNRG KPNWEHLNED LHVLITVEDA QNRAEIKLKR AVEEVKKLLV 190 200 210 220 230 240 PAAEGEDSLK KMQLMELAIL NGTYRDANIK SPALAFSLAA TAQAAPRIIT GPAPVLPPAA 250 260 270 280 290 300 LRTPTPAGPT IMPLIRQIQT AVMPNGTPHP TAAIVPPGPE AGLIYTPYEY PYTLAPATSI 310 LEYPIEPSGV LGMAFPTKG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Expression of Hqk encoding a KH RNA binding protein is altered in human glioma." Li Z.Z., Kondo T., Murata T., Ebersole T.A., Nishi T., Tada K., Ushio Y., Yamamura K., Abe K. Jpn. J. Cancer Res. 93:167-177(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1; 4 AND 5). Tissue: Brain.
[2]	"Molecular cloning of human QUAKING gene." Xia J.-H., Xiao J.-F., He Y.-G., Yu K.-P., Pan Q., Dai H.-P. Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 5-341 (ISOFORM 6).
[3]	Li H., Nong W., Zhou G., Ke R., Shen C., Zhong G., Liang M., Tang Z., Huang B., Lin L., Yang S. Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 5-341 (ISOFORM 3).
[4]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Placenta and Skin.
[6]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 15-341 (ISOFORM 1). Tissue: Embryo.
[7]	"Sam68 RNA binding protein is an in vivo substrate for protein arginine N-methyltransferase 1." Cote J., Boisvert F.-M., Boulanger M.-C., Bedford M.T., Richard S. Mol. Biol. Cell 14:274-287(2003) [PubMed] [Europe PMC] [Abstract] Cited for: METHYLATION.
[8]	"Human QKI, a new candidate gene for schizophrenia involved in myelination." Aeberg K., Saetre P., Lindholm E., Ekholm B., Pettersson U., Adolfsson R., Jazin E. Am. J. Med. Genet. B Neuropsychiatr. Genet. 141:84-90(2006) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[9]	"Human QKI, a potential regulator of mRNA expression of human oligodendrocyte-related genes involved in schizophrenia." Aberg K., Saetre P., Jareborg N., Jazin E. Proc. Natl. Acad. Sci. U.S.A. 103:7482-7487(2006) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION AS REGULATOR OF OLIGODENDROCYTE DIFFERENTIATION.
[10]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[11]	"A Y2H-seq approach defines the human protein methyltransferase interactome." Weimann M., Grossmann A., Woodsmith J., Ozkan Z., Birth P., Meierhofer D., Benlasfer N., Valovka T., Timmermann B., Wanker E.E., Sauer S., Stelzl U. Nat. Methods 0:0-0(2013) [PubMed] [Europe PMC] [Abstract] Cited for: METHYLATION AT ARG-242 BY CARM1.
[12]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] GLN-336.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB067798 mRNA. Translation: BAB69496.1. AB067799 mRNA. Translation: BAB69497.1. AB067800 mRNA. Translation: BAB69498.1. AB067801 mRNA. Translation: BAB69499.1. AB067808 Genomic DNA. Translation: BAB69681.1. AF142417 mRNA. Translation: AAF63412.1. Sequence problems. AF142418 mRNA. Translation: AAF63413.1. Sequence problems. AF142419 mRNA. Translation: AAF63414.1. Sequence problems. AF142420 mRNA. Translation: AAF63415.1. Sequence problems. AF142421 mRNA. Translation: AAF63416.1. Sequence problems. AF142422 mRNA. Translation: AAF63417.1. Sequence problems. AY780788 mRNA. Translation: AAV98358.1. DQ323998 mRNA. Translation: ABC88600.1. AL356119, AL031781 Genomic DNA. Translation: CAI23022.1. AL356119, AL031781 Genomic DNA. Translation: CAI23023.1. AL356119, AL031781 Genomic DNA. Translation: CAI23024.1. AL031781, AL356119 Genomic DNA. Translation: CAI21651.1. AL031781, AL356119 Genomic DNA. Translation: CAI21652.1. AL031781, AL356119 Genomic DNA. Translation: CAI21653.1. BC012222 mRNA. Translation: AAH12222.1. BC019917 mRNA. Translation: AAH19917.1. AK027309 mRNA. Translation: BAB55032.1. Different initiation.
IPI	IPI00385562. IPI00514277. IPI00736672. IPI00749287. IPI00759828. IPI00942653.
RefSeq	NP_006766.1. NM_006775.2. NP_996735.1. NM_206853.2. NP_996736.1. NM_206854.2. NP_996737.1. NM_206855.2.
UniGene	Hs.510324.
3D structure databases
ProteinModelPortal	Q96PU8.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96PU8. 23 interactions.
MINT	MINT-1445480.
PTM databases
PhosphoSite	Q96PU8.
Polymorphism databases
DMDM	74761039.
Proteomic databases
PaxDb	Q96PU8.
PRIDE	Q96PU8.
Protocols and materials databases
DNASU	9444.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000275262; ENSP00000275262; ENSG00000112531. ENST00000361195; ENSP00000354867; ENSG00000112531. ENST00000361752; ENSP00000355094; ENSG00000112531. ENST00000361758; ENSP00000354951; ENSG00000112531. ENST00000392127; ENSP00000375973; ENSG00000112531. ENST00000424802; ENSP00000408382; ENSG00000112531. ENST00000453779; ENSP00000408775; ENSG00000112531.
GeneID	9444.
KEGG	hsa:9444.
UCSC	uc003que.3. human. uc003quf.3. human. uc003qug.3. human. uc003quh.3. human. uc003qui.3. human. uc003quj.3. human.
Organism-specific databases
CTD	9444.
GeneCards	GC06P163835.
HGNC	HGNC:21100. QKI.
HPA	CAB022602. HPA019123.
MIM	609590. gene.
neXtProt	NX_Q96PU8.
PharmGKB	PA134912180.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5176.
HOVERGEN	HBG093883.
InParanoid	Q96PU8.
KO	K14945.
OMA	GMAFPTK.
OrthoDB	EOG4RFKSZ.
Gene expression databases
ArrayExpress	Q96PU8.
Bgee	Q96PU8.
Genevestigator	Q96PU8.
GermOnline	ENSG00000112531. Homo sapiens.
Family and domain databases
InterPro	IPR004087. KH_dom. IPR004088. KH_dom_type_1. [Graphical view]
Pfam	PF00013. KH_1. 1 hit. [Graphical view]
SMART	SM00322. KH. 1 hit. [Graphical view]
PROSITE	PS50084. KH_TYPE_1. False negative. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	QKI. human.
GenomeRNAi	9444.
NextBio	35368.
SOURCE	Search...

Entry information

Entry name

QKI_HUMAN

Accession

Primary (citable) accession number: Q96PU8
Secondary accession number(s): Q2I375 , Q5MJQ1, Q969L9, Q96EJ3, Q96KA3, Q96PU6, Q96PU7, Q9P0X6, Q9P0X7, Q9P0X8, Q9P0X9, Q9P0Y0, Q9P0Y1

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 13, 2006
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 99 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.