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Protein

Putative double homeobox protein 3

Gene

DUX3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi46 – 10560Homeobox 1PROSITE-ProRule annotationAdd
BLAST
DNA bindingi121 – 18060Homeobox 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative double homeobox protein 3
Gene namesi
Name:DUX3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:3081. DUX3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27537.

Polymorphism and mutation databases

DMDMi74717114.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 197197Putative double homeobox protein 3PRO_0000252412Add
BLAST

Proteomic databases

PeptideAtlasiQ96PT4.
PRIDEiQ96PT4.

Expressioni

Tissue specificityi

Expressed in hepatoma Hep3B cells.1 Publication

Developmental stagei

Expressed in fetal tissue.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi117751. 1 interaction.
IntActiQ96PT4. 3 interactions.
MINTiMINT-7970020.

Structurei

3D structure databases

ProteinModelPortaliQ96PT4.
SMRiQ96PT4. Positions 47-99, 120-175.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the paired homeobox family.Curated
Contains 2 homeobox DNA-binding domains.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox, Repeat

Phylogenomic databases

HOVERGENiHBG081466.
InParanoidiQ96PT4.
PhylomeDBiQ96PT4.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
InterProiIPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF00046. Homeobox. 2 hits.
[Graphical view]
PRINTSiPR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 2 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96PT4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPAEVHGSPP ASLCPCPSVK FRPGLPAMAL LTALDDTLPE EAQGPGRRMI
60 70 80 90 100
LLSTPSQSDA LRACFERNLY PGIATKEQLA QGIDIPEPRV QIWFQNERSC
110 120 130 140 150
QLRQHRRQSR PWPGRRDPQK GRRKRTAITG SQTALLLRAF EKDRFPGIPA
160 170 180 190
REELARETGL PESRIQLWFQ NRRARHWGQS GRAPTQASIR CNAAPIG
Length:197
Mass (Da):22,130
Last modified:December 1, 2001 - v1
Checksum:i4545E2738BFCE954
GO
Isoform 2 (identifier: Q96PT4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-27: Missing.

Show »
Length:170
Mass (Da):19,402
Checksum:i43F459BDEDAAAA57
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2727Missing in isoform 2. CuratedVSP_020958Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF133130 Genomic DNA. Translation: AAL02242.1.
AF133130 Genomic DNA. Translation: AAD33597.1.
RefSeqiNP_036280.2. NM_012148.2. [Q96PT4-1]

Genome annotation databases

GeneIDi26582.
KEGGihsa:26582.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF133130 Genomic DNA. Translation: AAL02242.1.
AF133130 Genomic DNA. Translation: AAD33597.1.
RefSeqiNP_036280.2. NM_012148.2. [Q96PT4-1]

3D structure databases

ProteinModelPortaliQ96PT4.
SMRiQ96PT4. Positions 47-99, 120-175.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117751. 1 interaction.
IntActiQ96PT4. 3 interactions.
MINTiMINT-7970020.

Polymorphism and mutation databases

DMDMi74717114.

Proteomic databases

PeptideAtlasiQ96PT4.
PRIDEiQ96PT4.

Protocols and materials databases

DNASUi26582.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi26582.
KEGGihsa:26582.

Organism-specific databases

CTDi26582.
GeneCardsiDUX3.
HGNCiHGNC:3081. DUX3.
MIMi611443. gene.
neXtProtiNX_Q96PT4.
PharmGKBiPA27537.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG081466.
InParanoidiQ96PT4.
PhylomeDBiQ96PT4.

Miscellaneous databases

GenomeRNAii26582.
PROiQ96PT4.
SOURCEiSearch...

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
InterProiIPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF00046. Homeobox. 2 hits.
[Graphical view]
PRINTSiPR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 2 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDUX3_HUMAN
AccessioniPrimary (citable) accession number: Q96PT4
Secondary accession number(s): Q9UND2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: December 1, 2001
Last modified: July 6, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

DUX genes are present in 3.3-kilobase elements, a tandem repeat family scattered in the genome found on the short arms of all acrocentric chromosomes as well as on several other chromosomes. May be functional despite lack of introns and of a poly(A) addition signal.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.