Q96PS8 (AQP10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aquaporin-10
Short name=AQP-10

Alternative name(s):
Aquaglyceroporin-10
Small intestine aquaporin

Gene names

Name:

AQP10

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	301 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Water channel required to promote glycerol permeability and water transport across cell membranes. May contribute to water transport in the upper portion of small intestine. Isoform 2 is not permeable to urea and glycerol. Ref.1 Ref.2
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Expressed exclusively in duodenum and jejunum. Highest expression in absorptive epithelial cells at the tips of villi in the jejunum.
Domain	Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
Sequence similarities	Belongs to the MIP/aquaporin (TC 1.A.8) family. [View classification]

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	response to toxin Inferred from direct assay PubMed 17575980. Source: UniProtKB transmembrane transport Traceable author statement. Source: Reactome water transport Traceable author statement. Source: Reactome
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular_function	transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96PS8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96PS8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     236-301: SAGNGWWWVP...ASAQMLECKL → RWETDSPGAGLHSPSSAKGSVPGSTALCL

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 301	301	Aquaporin-10		PRO_0000063967
Regions
	Topological domain	1 – 27	27	Cytoplasmic Potential
	Transmembrane	28 – 48	21	Helical; Potential
	Topological domain	49 – 52	4	Extracellular Potential
	Transmembrane	53 – 73	21	Helical; Potential
	Topological domain	74 – 101	28	Cytoplasmic Potential
	Transmembrane	102 – 122	21	Helical; Potential
	Topological domain	123 – 156	34	Extracellular Potential
	Transmembrane	157 – 177	21	Helical; Potential
	Topological domain	178 – 187	10	Cytoplasmic Potential
	Transmembrane	188 – 208	21	Helical; Potential
	Topological domain	209 – 301	93	Extracellular Potential
	Motif	82 – 84	3	NPA 1
	Motif	214 – 216	3	NPA 2
Natural variations
	Alternative sequence	236 – 301	66	SAGNG…LECKL → RWETDSPGAGLHSPSSAKGS VPGSTALCL in isoform 2.		VSP_010211
	Natural variant	15	1	R → Q. Corresponds to variant rs6668968 [ dbSNP | Ensembl ].		VAR_033519
	Natural variant	123	1	H → Y. Corresponds to variant rs6685323 [ dbSNP | Ensembl ].		VAR_050063

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 10, 2004. Version 2. Checksum: CB2A7AB680548987	FASTA	301	31,763
	10 20 30 40 50 60 MVFTQAPAEI MGHLRIRSLL ARQCLAEFLG VFVLMLLTQG AVAQAVTSGE TKGNFFTMFL 70 80 90 100 110 120 AGSLAVTIAI YVGGNVSGAH LNPAFSLAMC IVGRLPWVKL PIYILVQLLS AFCASGATYV 130 140 150 160 170 180 LYHDALQNYT GGNLTVTGPK ETASIFATYP APYLSLNNGF LDQVLGTGML IVGLLAILDR 190 200 210 220 230 240 RNKGVPAGLE PVVVGMLILA LGLSMGANCG IPLNPARDLG PRLFTYVAGW GPEVFSAGNG 250 260 270 280 290 300 WWWVPVVAPL VGATVGTATY QLLVALHHPE GPEPAQDLVS AQHKASELET PASAQMLECK L
	Isoform 2 [UniParc]. Checksum: 1332FF9533743412	FASTA	264	27,672
	10 20 30 40 50 60 MVFTQAPAEI MGHLRIRSLL ARQCLAEFLG VFVLMLLTQG AVAQAVTSGE TKGNFFTMFL 70 80 90 100 110 120 AGSLAVTIAI YVGGNVSGAH LNPAFSLAMC IVGRLPWVKL PIYILVQLLS AFCASGATYV 130 140 150 160 170 180 LYHDALQNYT GGNLTVTGPK ETASIFATYP APYLSLNNGF LDQVLGTGML IVGLLAILDR 190 200 210 220 230 240 RNKGVPAGLE PVVVGMLILA LGLSMGANCG IPLNPARDLG PRLFTYVAGW GPEVFRWETD 250 260 SPGAGLHSPS SAKGSVPGST ALCL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of a new aquaporin (AQP10) abundantly expressed in duodenum and jejunum." Hatakeyama S., Yoshida Y., Tani T., Koyama Y., Nihei K., Ohshiro K., Kamiie J., Yaoita E., Suda T., Hatakeyama K., Yamamoto T. Biochem. Biophys. Res. Commun. 287:814-819(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION. Tissue: Jejunum.
[2]	"Cloning and identification of a new member of water channel (AQP10) as an aquaglyceroporin." Ishibashi K., Morinaga T., Kuwahara M., Sasaki S., Imai M. Biochim. Biophys. Acta 1576:335-340(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION.
[3]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Lung.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF159174 mRNA. Translation: AAL25998.1. AB066105 mRNA. Translation: BAB91223.1. AL354980 Genomic DNA. Translation: CAH70482.1. AL354980 Genomic DNA. Translation: CAH70483.1. BC069607 mRNA. Translation: AAH69607.1. BC074896 mRNA. Translation: AAH74896.1. BC074897 mRNA. Translation: AAH74897.1.
IPI	IPI00044651. IPI00185014.
PIR	JC7772.
RefSeq	NP_536354.2. NM_080429.2.
UniGene	Hs.259048.
3D structure databases
ProteinModelPortal	Q96PS8.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000318355.
Polymorphism databases
DMDM	47117905.
Proteomic databases
PRIDE	Q96PS8.
Protocols and materials databases
DNASU	89872.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000324978; ENSP00000318355; ENSG00000143595. ENST00000484864; ENSP00000420341; ENSG00000143595.
GeneID	89872.
KEGG	hsa:89872.
UCSC	uc001feu.3. human.
Organism-specific databases
CTD	89872.
GeneCards	GC01P154294.
HGNC	HGNC:16029. AQP10.
MIM	606578. gene.
neXtProt	NX_Q96PS8.
PharmGKB	PA24919.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0580.
HOGENOM	HOG000288287.
HOVERGEN	HBG106057.
InParanoid	Q96PS8.
KO	K09878.
OMA	SGWIAIV.
OrthoDB	EOG470TJ1.
PhylomeDB	Q96PS8.
Enzyme and pathway databases
Reactome	REACT_15518. Transmembrane transport of small molecules.
Gene expression databases
Bgee	Q96PS8.
CleanEx	HS_AQP10.
Genevestigator	Q96PS8.
GermOnline	ENSG00000143595. Homo sapiens.
Family and domain databases
Gene3D	1.20.1080.10. 1 hit.
InterPro	IPR023271. Aquaporin-like. IPR026252. Aquaporin_10. IPR000425. MIP. IPR022357. MIP_CS. [Graphical view]
PANTHER	PTHR19139. PTHR19139. 1 hit.
Pfam	PF00230. MIP. 1 hit. [Graphical view]
PRINTS	PR02022. AQUAPORIN10M. PR00783. MINTRINSICP.
SUPFAM	SSF81338. MIP. 1 hit.
TIGRFAMs	TIGR00861. MIP. 1 hit.
PROSITE	PS00221. MIP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	89872.
NextBio	76374.
SOURCE	Search...

Entry information

Entry name

AQP10_HUMAN

Accession

Primary (citable) accession number: Q96PS8
Secondary accession number(s): Q5VYD3, Q5VYD4, Q8NG70

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2002
Last sequence update:	May 10, 2004
Last modified:	May 1, 2013
This is version 100 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.