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Q96PS8

- AQP10_HUMAN

UniProt

Q96PS8 - AQP10_HUMAN

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Protein
Aquaporin-10
Gene
AQP10
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Water channel required to promote glycerol permeability and water transport across cell membranes. May contribute to water transport in the upper portion of small intestine. Isoform 2 is not permeable to urea and glycerol.2 Publications

GO - Molecular functioni

  1. transporter activity Source: InterPro

GO - Biological processi

  1. response to toxic substance Source: UniProtKB
  2. transmembrane transport Source: Reactome
  3. water transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiREACT_23826. Passive transport by Aquaporins.

Protein family/group databases

TCDBi1.A.8.9.5. the major intrinsic protein (mip) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Aquaporin-10
Short name:
AQP-10
Alternative name(s):
Aquaglyceroporin-10
Small intestine aquaporin
Gene namesi
Name:AQP10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:16029. AQP10.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2727Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei28 – 4821Helical; Reviewed prediction
Add
BLAST
Topological domaini49 – 524Extracellular Reviewed prediction
Transmembranei53 – 7321Helical; Reviewed prediction
Add
BLAST
Topological domaini74 – 10128Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei102 – 12221Helical; Reviewed prediction
Add
BLAST
Topological domaini123 – 15634Extracellular Reviewed prediction
Add
BLAST
Transmembranei157 – 17721Helical; Reviewed prediction
Add
BLAST
Topological domaini178 – 18710Cytoplasmic Reviewed prediction
Transmembranei188 – 20821Helical; Reviewed prediction
Add
BLAST
Topological domaini209 – 30193Extracellular Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24919.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 301301Aquaporin-10
PRO_0000063967Add
BLAST

Proteomic databases

PRIDEiQ96PS8.

Expressioni

Tissue specificityi

Expressed exclusively in duodenum and jejunum. Highest expression in absorptive epithelial cells at the tips of villi in the jejunum.

Gene expression databases

BgeeiQ96PS8.
CleanExiHS_AQP10.
GenevestigatoriQ96PS8.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000318355.

Structurei

3D structure databases

ProteinModelPortaliQ96PS8.
SMRiQ96PS8. Positions 20-267.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi82 – 843NPA 1
Motifi214 – 2163NPA 2

Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0580.
HOGENOMiHOG000288287.
HOVERGENiHBG106057.
InParanoidiQ96PS8.
KOiK09878.
OMAiAMCLLGR.
OrthoDBiEOG7J9VPP.
PhylomeDBiQ96PS8.
TreeFamiTF313173.

Family and domain databases

Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR026252. Aquaporin_10.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR02022. AQUAPORIN10M.
PR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.
PROSITEiPS00221. MIP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96PS8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MVFTQAPAEI MGHLRIRSLL ARQCLAEFLG VFVLMLLTQG AVAQAVTSGE    50
TKGNFFTMFL AGSLAVTIAI YVGGNVSGAH LNPAFSLAMC IVGRLPWVKL 100
PIYILVQLLS AFCASGATYV LYHDALQNYT GGNLTVTGPK ETASIFATYP 150
APYLSLNNGF LDQVLGTGML IVGLLAILDR RNKGVPAGLE PVVVGMLILA 200
LGLSMGANCG IPLNPARDLG PRLFTYVAGW GPEVFSAGNG WWWVPVVAPL 250
VGATVGTATY QLLVALHHPE GPEPAQDLVS AQHKASELET PASAQMLECK 300
L 301
Length:301
Mass (Da):31,763
Last modified:May 10, 2004 - v2
Checksum:iCB2A7AB680548987
GO
Isoform 2 (identifier: Q96PS8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     236-301: SAGNGWWWVP...ASAQMLECKL → RWETDSPGAGLHSPSSAKGSVPGSTALCL

Show »
Length:264
Mass (Da):27,672
Checksum:i1332FF9533743412
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti15 – 151R → Q.
Corresponds to variant rs6668968 [ dbSNP | Ensembl ].
VAR_033519
Natural varianti123 – 1231H → Y.
Corresponds to variant rs6685323 [ dbSNP | Ensembl ].
VAR_050063

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei236 – 30166SAGNG…LECKL → RWETDSPGAGLHSPSSAKGS VPGSTALCL in isoform 2.
VSP_010211Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF159174 mRNA. Translation: AAL25998.1.
AB066105 mRNA. Translation: BAB91223.1.
AL354980 Genomic DNA. Translation: CAH70482.1.
AL354980 Genomic DNA. Translation: CAH70483.1.
BC069607 mRNA. Translation: AAH69607.1.
BC074896 mRNA. Translation: AAH74896.1.
BC074897 mRNA. Translation: AAH74897.1.
CCDSiCCDS1065.1. [Q96PS8-1]
PIRiJC7772.
RefSeqiNP_536354.2. NM_080429.2. [Q96PS8-1]
UniGeneiHs.259048.

Genome annotation databases

EnsembliENST00000324978; ENSP00000318355; ENSG00000143595. [Q96PS8-1]
ENST00000484864; ENSP00000420341; ENSG00000143595. [Q96PS8-2]
GeneIDi89872.
KEGGihsa:89872.
UCSCiuc001feu.3. human. [Q96PS8-1]

Polymorphism databases

DMDMi47117905.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF159174 mRNA. Translation: AAL25998.1 .
AB066105 mRNA. Translation: BAB91223.1 .
AL354980 Genomic DNA. Translation: CAH70482.1 .
AL354980 Genomic DNA. Translation: CAH70483.1 .
BC069607 mRNA. Translation: AAH69607.1 .
BC074896 mRNA. Translation: AAH74896.1 .
BC074897 mRNA. Translation: AAH74897.1 .
CCDSi CCDS1065.1. [Q96PS8-1 ]
PIRi JC7772.
RefSeqi NP_536354.2. NM_080429.2. [Q96PS8-1 ]
UniGenei Hs.259048.

3D structure databases

ProteinModelPortali Q96PS8.
SMRi Q96PS8. Positions 20-267.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000318355.

Chemistry

GuidetoPHARMACOLOGYi 697.

Protein family/group databases

TCDBi 1.A.8.9.5. the major intrinsic protein (mip) family.

Polymorphism databases

DMDMi 47117905.

Proteomic databases

PRIDEi Q96PS8.

Protocols and materials databases

DNASUi 89872.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000324978 ; ENSP00000318355 ; ENSG00000143595 . [Q96PS8-1 ]
ENST00000484864 ; ENSP00000420341 ; ENSG00000143595 . [Q96PS8-2 ]
GeneIDi 89872.
KEGGi hsa:89872.
UCSCi uc001feu.3. human. [Q96PS8-1 ]

Organism-specific databases

CTDi 89872.
GeneCardsi GC01P154294.
HGNCi HGNC:16029. AQP10.
MIMi 606578. gene.
neXtProti NX_Q96PS8.
PharmGKBi PA24919.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0580.
HOGENOMi HOG000288287.
HOVERGENi HBG106057.
InParanoidi Q96PS8.
KOi K09878.
OMAi AMCLLGR.
OrthoDBi EOG7J9VPP.
PhylomeDBi Q96PS8.
TreeFami TF313173.

Enzyme and pathway databases

Reactomei REACT_23826. Passive transport by Aquaporins.

Miscellaneous databases

GenomeRNAii 89872.
NextBioi 76374.
PROi Q96PS8.
SOURCEi Search...

Gene expression databases

Bgeei Q96PS8.
CleanExi HS_AQP10.
Genevestigatori Q96PS8.

Family and domain databases

Gene3Di 1.20.1080.10. 1 hit.
InterProi IPR023271. Aquaporin-like.
IPR026252. Aquaporin_10.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view ]
PANTHERi PTHR19139. PTHR19139. 1 hit.
Pfami PF00230. MIP. 1 hit.
[Graphical view ]
PRINTSi PR02022. AQUAPORIN10M.
PR00783. MINTRINSICP.
SUPFAMi SSF81338. SSF81338. 1 hit.
TIGRFAMsi TIGR00861. MIP. 1 hit.
PROSITEi PS00221. MIP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION.
    Tissue: Jejunum.
  2. "Cloning and identification of a new member of water channel (AQP10) as an aquaglyceroporin."
    Ishibashi K., Morinaga T., Kuwahara M., Sasaki S., Imai M.
    Biochim. Biophys. Acta 1576:335-340(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung.

Entry informationi

Entry nameiAQP10_HUMAN
AccessioniPrimary (citable) accession number: Q96PS8
Secondary accession number(s): Q5VYD3, Q5VYD4, Q8NG70
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2002
Last sequence update: May 10, 2004
Last modified: September 3, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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