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Protein

Aquaporin-10

Gene

AQP10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Water channel required to promote glycerol permeability and water transport across cell membranes. May contribute to water transport in the upper portion of small intestine. Isoform 2 is not permeable to urea and glycerol.2 Publications

GO - Molecular functioni

  1. glycerol channel activity Source: GO_Central
  2. urea transmembrane transporter activity Source: GO_Central
  3. water channel activity Source: GO_Central

GO - Biological processi

  1. cellular water homeostasis Source: GO_Central
  2. glycerol transport Source: GOC
  3. ion transmembrane transport Source: GO_Central
  4. response to toxic substance Source: UniProtKB
  5. transmembrane transport Source: Reactome
  6. urea transmembrane transport Source: GO_Central
  7. water transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiREACT_23826. Passive transport by Aquaporins.

Protein family/group databases

TCDBi1.A.8.9.5. the major intrinsic protein (mip) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Aquaporin-10
Short name:
AQP-10
Alternative name(s):
Aquaglyceroporin-10
Small intestine aquaporin
Gene namesi
Name:AQP10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:16029. AQP10.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2727CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei28 – 4821HelicalSequence AnalysisAdd
BLAST
Topological domaini49 – 524ExtracellularSequence Analysis
Transmembranei53 – 7321HelicalSequence AnalysisAdd
BLAST
Topological domaini74 – 10128CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei102 – 12221HelicalSequence AnalysisAdd
BLAST
Topological domaini123 – 15634ExtracellularSequence AnalysisAdd
BLAST
Transmembranei157 – 17721HelicalSequence AnalysisAdd
BLAST
Topological domaini178 – 18710CytoplasmicSequence Analysis
Transmembranei188 – 20821HelicalSequence AnalysisAdd
BLAST
Topological domaini209 – 30193ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: GO_Central
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24919.

Polymorphism and mutation databases

BioMutaiAQP10.
DMDMi47117905.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 301301Aquaporin-10PRO_0000063967Add
BLAST

Proteomic databases

PRIDEiQ96PS8.

Expressioni

Tissue specificityi

Expressed exclusively in duodenum and jejunum. Highest expression in absorptive epithelial cells at the tips of villi in the jejunum.

Gene expression databases

BgeeiQ96PS8.
CleanExiHS_AQP10.
GenevestigatoriQ96PS8.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000318355.

Structurei

3D structure databases

ProteinModelPortaliQ96PS8.
SMRiQ96PS8. Positions 20-267.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi82 – 843NPA 1
Motifi214 – 2163NPA 2

Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0580.
GeneTreeiENSGT00510000046311.
HOGENOMiHOG000288287.
HOVERGENiHBG106057.
InParanoidiQ96PS8.
KOiK09878.
OMAiASDLEMP.
OrthoDBiEOG7J9VPP.
PhylomeDBiQ96PS8.
TreeFamiTF313173.

Family and domain databases

Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR026252. Aquaporin_10.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR02022. AQUAPORIN10M.
PR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.
PROSITEiPS00221. MIP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96PS8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVFTQAPAEI MGHLRIRSLL ARQCLAEFLG VFVLMLLTQG AVAQAVTSGE
60 70 80 90 100
TKGNFFTMFL AGSLAVTIAI YVGGNVSGAH LNPAFSLAMC IVGRLPWVKL
110 120 130 140 150
PIYILVQLLS AFCASGATYV LYHDALQNYT GGNLTVTGPK ETASIFATYP
160 170 180 190 200
APYLSLNNGF LDQVLGTGML IVGLLAILDR RNKGVPAGLE PVVVGMLILA
210 220 230 240 250
LGLSMGANCG IPLNPARDLG PRLFTYVAGW GPEVFSAGNG WWWVPVVAPL
260 270 280 290 300
VGATVGTATY QLLVALHHPE GPEPAQDLVS AQHKASELET PASAQMLECK

L
Length:301
Mass (Da):31,763
Last modified:May 10, 2004 - v2
Checksum:iCB2A7AB680548987
GO
Isoform 2 (identifier: Q96PS8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     236-301: SAGNGWWWVP...ASAQMLECKL → RWETDSPGAGLHSPSSAKGSVPGSTALCL

Show »
Length:264
Mass (Da):27,672
Checksum:i1332FF9533743412
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti15 – 151R → Q.
Corresponds to variant rs6668968 [ dbSNP | Ensembl ].
VAR_033519
Natural varianti123 – 1231H → Y.
Corresponds to variant rs6685323 [ dbSNP | Ensembl ].
VAR_050063

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei236 – 30166SAGNG…LECKL → RWETDSPGAGLHSPSSAKGS VPGSTALCL in isoform 2. 1 PublicationVSP_010211Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF159174 mRNA. Translation: AAL25998.1.
AB066105 mRNA. Translation: BAB91223.1.
AL354980 Genomic DNA. Translation: CAH70482.1.
AL354980 Genomic DNA. Translation: CAH70483.1.
BC069607 mRNA. Translation: AAH69607.1.
BC074896 mRNA. Translation: AAH74896.1.
BC074897 mRNA. Translation: AAH74897.1.
CCDSiCCDS1065.1. [Q96PS8-1]
PIRiJC7772.
RefSeqiNP_536354.2. NM_080429.2. [Q96PS8-1]
UniGeneiHs.259048.

Genome annotation databases

EnsembliENST00000324978; ENSP00000318355; ENSG00000143595. [Q96PS8-1]
ENST00000484864; ENSP00000420341; ENSG00000143595. [Q96PS8-2]
GeneIDi89872.
KEGGihsa:89872.
UCSCiuc001feu.3. human. [Q96PS8-1]

Polymorphism and mutation databases

BioMutaiAQP10.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF159174 mRNA. Translation: AAL25998.1.
AB066105 mRNA. Translation: BAB91223.1.
AL354980 Genomic DNA. Translation: CAH70482.1.
AL354980 Genomic DNA. Translation: CAH70483.1.
BC069607 mRNA. Translation: AAH69607.1.
BC074896 mRNA. Translation: AAH74896.1.
BC074897 mRNA. Translation: AAH74897.1.
CCDSiCCDS1065.1. [Q96PS8-1]
PIRiJC7772.
RefSeqiNP_536354.2. NM_080429.2. [Q96PS8-1]
UniGeneiHs.259048.

3D structure databases

ProteinModelPortaliQ96PS8.
SMRiQ96PS8. Positions 20-267.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000318355.

Chemistry

GuidetoPHARMACOLOGYi697.

Protein family/group databases

TCDBi1.A.8.9.5. the major intrinsic protein (mip) family.

Polymorphism and mutation databases

BioMutaiAQP10.
DMDMi47117905.

Proteomic databases

PRIDEiQ96PS8.

Protocols and materials databases

DNASUi89872.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000324978; ENSP00000318355; ENSG00000143595. [Q96PS8-1]
ENST00000484864; ENSP00000420341; ENSG00000143595. [Q96PS8-2]
GeneIDi89872.
KEGGihsa:89872.
UCSCiuc001feu.3. human. [Q96PS8-1]

Organism-specific databases

CTDi89872.
GeneCardsiGC01P154294.
HGNCiHGNC:16029. AQP10.
MIMi606578. gene.
neXtProtiNX_Q96PS8.
PharmGKBiPA24919.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0580.
GeneTreeiENSGT00510000046311.
HOGENOMiHOG000288287.
HOVERGENiHBG106057.
InParanoidiQ96PS8.
KOiK09878.
OMAiASDLEMP.
OrthoDBiEOG7J9VPP.
PhylomeDBiQ96PS8.
TreeFamiTF313173.

Enzyme and pathway databases

ReactomeiREACT_23826. Passive transport by Aquaporins.

Miscellaneous databases

GenomeRNAii89872.
NextBioi76374.
PROiQ96PS8.
SOURCEiSearch...

Gene expression databases

BgeeiQ96PS8.
CleanExiHS_AQP10.
GenevestigatoriQ96PS8.

Family and domain databases

Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR026252. Aquaporin_10.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR02022. AQUAPORIN10M.
PR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.
PROSITEiPS00221. MIP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION.
    Tissue: Jejunum.
  2. "Cloning and identification of a new member of water channel (AQP10) as an aquaglyceroporin."
    Ishibashi K., Morinaga T., Kuwahara M., Sasaki S., Imai M.
    Biochim. Biophys. Acta 1576:335-340(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung.

Entry informationi

Entry nameiAQP10_HUMAN
AccessioniPrimary (citable) accession number: Q96PS8
Secondary accession number(s): Q5VYD3, Q5VYD4, Q8NG70
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2002
Last sequence update: May 10, 2004
Last modified: April 29, 2015
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.