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Q96PS8

- AQP10_HUMAN

UniProt

Q96PS8 - AQP10_HUMAN

Protein

Aquaporin-10

Gene

AQP10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 2 (10 May 2004)
      Previous versions | rss
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    Functioni

    Water channel required to promote glycerol permeability and water transport across cell membranes. May contribute to water transport in the upper portion of small intestine. Isoform 2 is not permeable to urea and glycerol.2 Publications

    GO - Molecular functioni

    1. transporter activity Source: InterPro

    GO - Biological processi

    1. response to toxic substance Source: UniProtKB
    2. transmembrane transport Source: Reactome
    3. water transport Source: Reactome

    Keywords - Biological processi

    Transport

    Enzyme and pathway databases

    ReactomeiREACT_23826. Passive transport by Aquaporins.

    Protein family/group databases

    TCDBi1.A.8.9.5. the major intrinsic protein (mip) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aquaporin-10
    Short name:
    AQP-10
    Alternative name(s):
    Aquaglyceroporin-10
    Small intestine aquaporin
    Gene namesi
    Name:AQP10
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:16029. AQP10.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA24919.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 301301Aquaporin-10PRO_0000063967Add
    BLAST

    Proteomic databases

    PRIDEiQ96PS8.

    Expressioni

    Tissue specificityi

    Expressed exclusively in duodenum and jejunum. Highest expression in absorptive epithelial cells at the tips of villi in the jejunum.

    Gene expression databases

    BgeeiQ96PS8.
    CleanExiHS_AQP10.
    GenevestigatoriQ96PS8.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000318355.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96PS8.
    SMRiQ96PS8. Positions 20-267.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2727CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini49 – 524ExtracellularSequence Analysis
    Topological domaini74 – 10128CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini123 – 15634ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini178 – 18710CytoplasmicSequence Analysis
    Topological domaini209 – 30193ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei28 – 4821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei53 – 7321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei102 – 12221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei157 – 17721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei188 – 20821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi82 – 843NPA 1
    Motifi214 – 2163NPA 2

    Domaini

    Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

    Sequence similaritiesi

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0580.
    HOGENOMiHOG000288287.
    HOVERGENiHBG106057.
    InParanoidiQ96PS8.
    KOiK09878.
    OMAiAMCLLGR.
    OrthoDBiEOG7J9VPP.
    PhylomeDBiQ96PS8.
    TreeFamiTF313173.

    Family and domain databases

    Gene3Di1.20.1080.10. 1 hit.
    InterProiIPR023271. Aquaporin-like.
    IPR026252. Aquaporin_10.
    IPR000425. MIP.
    IPR022357. MIP_CS.
    [Graphical view]
    PANTHERiPTHR19139. PTHR19139. 1 hit.
    PfamiPF00230. MIP. 1 hit.
    [Graphical view]
    PRINTSiPR02022. AQUAPORIN10M.
    PR00783. MINTRINSICP.
    SUPFAMiSSF81338. SSF81338. 1 hit.
    TIGRFAMsiTIGR00861. MIP. 1 hit.
    PROSITEiPS00221. MIP. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96PS8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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    MVFTQAPAEI MGHLRIRSLL ARQCLAEFLG VFVLMLLTQG AVAQAVTSGE    50
    TKGNFFTMFL AGSLAVTIAI YVGGNVSGAH LNPAFSLAMC IVGRLPWVKL 100
    PIYILVQLLS AFCASGATYV LYHDALQNYT GGNLTVTGPK ETASIFATYP 150
    APYLSLNNGF LDQVLGTGML IVGLLAILDR RNKGVPAGLE PVVVGMLILA 200
    LGLSMGANCG IPLNPARDLG PRLFTYVAGW GPEVFSAGNG WWWVPVVAPL 250
    VGATVGTATY QLLVALHHPE GPEPAQDLVS AQHKASELET PASAQMLECK 300
    L 301
    Length:301
    Mass (Da):31,763
    Last modified:May 10, 2004 - v2
    Checksum:iCB2A7AB680548987
    GO
    Isoform 2 (identifier: Q96PS8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         236-301: SAGNGWWWVP...ASAQMLECKL → RWETDSPGAGLHSPSSAKGSVPGSTALCL

    Show »
    Length:264
    Mass (Da):27,672
    Checksum:i1332FF9533743412
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti15 – 151R → Q.
    Corresponds to variant rs6668968 [ dbSNP | Ensembl ].
    VAR_033519
    Natural varianti123 – 1231H → Y.
    Corresponds to variant rs6685323 [ dbSNP | Ensembl ].
    VAR_050063

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei236 – 30166SAGNG…LECKL → RWETDSPGAGLHSPSSAKGS VPGSTALCL in isoform 2. 1 PublicationVSP_010211Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF159174 mRNA. Translation: AAL25998.1.
    AB066105 mRNA. Translation: BAB91223.1.
    AL354980 Genomic DNA. Translation: CAH70482.1.
    AL354980 Genomic DNA. Translation: CAH70483.1.
    BC069607 mRNA. Translation: AAH69607.1.
    BC074896 mRNA. Translation: AAH74896.1.
    BC074897 mRNA. Translation: AAH74897.1.
    CCDSiCCDS1065.1. [Q96PS8-1]
    PIRiJC7772.
    RefSeqiNP_536354.2. NM_080429.2. [Q96PS8-1]
    UniGeneiHs.259048.

    Genome annotation databases

    EnsembliENST00000324978; ENSP00000318355; ENSG00000143595. [Q96PS8-1]
    ENST00000484864; ENSP00000420341; ENSG00000143595. [Q96PS8-2]
    GeneIDi89872.
    KEGGihsa:89872.
    UCSCiuc001feu.3. human. [Q96PS8-1]

    Polymorphism databases

    DMDMi47117905.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF159174 mRNA. Translation: AAL25998.1 .
    AB066105 mRNA. Translation: BAB91223.1 .
    AL354980 Genomic DNA. Translation: CAH70482.1 .
    AL354980 Genomic DNA. Translation: CAH70483.1 .
    BC069607 mRNA. Translation: AAH69607.1 .
    BC074896 mRNA. Translation: AAH74896.1 .
    BC074897 mRNA. Translation: AAH74897.1 .
    CCDSi CCDS1065.1. [Q96PS8-1 ]
    PIRi JC7772.
    RefSeqi NP_536354.2. NM_080429.2. [Q96PS8-1 ]
    UniGenei Hs.259048.

    3D structure databases

    ProteinModelPortali Q96PS8.
    SMRi Q96PS8. Positions 20-267.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000318355.

    Chemistry

    GuidetoPHARMACOLOGYi 697.

    Protein family/group databases

    TCDBi 1.A.8.9.5. the major intrinsic protein (mip) family.

    Polymorphism databases

    DMDMi 47117905.

    Proteomic databases

    PRIDEi Q96PS8.

    Protocols and materials databases

    DNASUi 89872.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000324978 ; ENSP00000318355 ; ENSG00000143595 . [Q96PS8-1 ]
    ENST00000484864 ; ENSP00000420341 ; ENSG00000143595 . [Q96PS8-2 ]
    GeneIDi 89872.
    KEGGi hsa:89872.
    UCSCi uc001feu.3. human. [Q96PS8-1 ]

    Organism-specific databases

    CTDi 89872.
    GeneCardsi GC01P154294.
    HGNCi HGNC:16029. AQP10.
    MIMi 606578. gene.
    neXtProti NX_Q96PS8.
    PharmGKBi PA24919.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0580.
    HOGENOMi HOG000288287.
    HOVERGENi HBG106057.
    InParanoidi Q96PS8.
    KOi K09878.
    OMAi AMCLLGR.
    OrthoDBi EOG7J9VPP.
    PhylomeDBi Q96PS8.
    TreeFami TF313173.

    Enzyme and pathway databases

    Reactomei REACT_23826. Passive transport by Aquaporins.

    Miscellaneous databases

    GenomeRNAii 89872.
    NextBioi 76374.
    PROi Q96PS8.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q96PS8.
    CleanExi HS_AQP10.
    Genevestigatori Q96PS8.

    Family and domain databases

    Gene3Di 1.20.1080.10. 1 hit.
    InterProi IPR023271. Aquaporin-like.
    IPR026252. Aquaporin_10.
    IPR000425. MIP.
    IPR022357. MIP_CS.
    [Graphical view ]
    PANTHERi PTHR19139. PTHR19139. 1 hit.
    Pfami PF00230. MIP. 1 hit.
    [Graphical view ]
    PRINTSi PR02022. AQUAPORIN10M.
    PR00783. MINTRINSICP.
    SUPFAMi SSF81338. SSF81338. 1 hit.
    TIGRFAMsi TIGR00861. MIP. 1 hit.
    PROSITEi PS00221. MIP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION.
      Tissue: Jejunum.
    2. "Cloning and identification of a new member of water channel (AQP10) as an aquaglyceroporin."
      Ishibashi K., Morinaga T., Kuwahara M., Sasaki S., Imai M.
      Biochim. Biophys. Acta 1576:335-340(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION.
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lung.

    Entry informationi

    Entry nameiAQP10_HUMAN
    AccessioniPrimary (citable) accession number: Q96PS8
    Secondary accession number(s): Q5VYD3, Q5VYD4, Q8NG70
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2002
    Last sequence update: May 10, 2004
    Last modified: October 1, 2014
    This is version 114 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3