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Q96PS8 (AQP10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aquaporin-10

Short name=AQP-10
Alternative name(s):
Aquaglyceroporin-10
Small intestine aquaporin
Gene names
Name:AQP10
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length301 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Water channel required to promote glycerol permeability and water transport across cell membranes. May contribute to water transport in the upper portion of small intestine. Isoform 2 is not permeable to urea and glycerol. Ref.1 Ref.2

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Expressed exclusively in duodenum and jejunum. Highest expression in absorptive epithelial cells at the tips of villi in the jejunum.

Domain

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Sequence similarities

Belongs to the MIP/aquaporin (TC 1.A.8) family. [View classification]

Ontologies

Keywords
   Biological processTransport
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainRepeat
Transmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processresponse to toxic substance

Inferred from direct assay PubMed 17575980. Source: UniProtKB

transmembrane transport

Traceable author statement. Source: Reactome

water transport

Traceable author statement. Source: Reactome

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Traceable author statement. Source: Reactome

   Molecular_functiontransporter activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q96PS8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q96PS8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     236-301: SAGNGWWWVP...ASAQMLECKL → RWETDSPGAGLHSPSSAKGSVPGSTALCL

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 301301Aquaporin-10
PRO_0000063967

Regions

Topological domain1 – 2727Cytoplasmic Potential
Transmembrane28 – 4821Helical; Potential
Topological domain49 – 524Extracellular Potential
Transmembrane53 – 7321Helical; Potential
Topological domain74 – 10128Cytoplasmic Potential
Transmembrane102 – 12221Helical; Potential
Topological domain123 – 15634Extracellular Potential
Transmembrane157 – 17721Helical; Potential
Topological domain178 – 18710Cytoplasmic Potential
Transmembrane188 – 20821Helical; Potential
Topological domain209 – 30193Extracellular Potential
Motif82 – 843NPA 1
Motif214 – 2163NPA 2

Natural variations

Alternative sequence236 – 30166SAGNG…LECKL → RWETDSPGAGLHSPSSAKGS VPGSTALCL in isoform 2.
VSP_010211
Natural variant151R → Q.
Corresponds to variant rs6668968 [ dbSNP | Ensembl ].
VAR_033519
Natural variant1231H → Y.
Corresponds to variant rs6685323 [ dbSNP | Ensembl ].
VAR_050063

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 10, 2004. Version 2.
Checksum: CB2A7AB680548987

FASTA30131,763
        10         20         30         40         50         60 
MVFTQAPAEI MGHLRIRSLL ARQCLAEFLG VFVLMLLTQG AVAQAVTSGE TKGNFFTMFL 

        70         80         90        100        110        120 
AGSLAVTIAI YVGGNVSGAH LNPAFSLAMC IVGRLPWVKL PIYILVQLLS AFCASGATYV 

       130        140        150        160        170        180 
LYHDALQNYT GGNLTVTGPK ETASIFATYP APYLSLNNGF LDQVLGTGML IVGLLAILDR 

       190        200        210        220        230        240 
RNKGVPAGLE PVVVGMLILA LGLSMGANCG IPLNPARDLG PRLFTYVAGW GPEVFSAGNG 

       250        260        270        280        290        300 
WWWVPVVAPL VGATVGTATY QLLVALHHPE GPEPAQDLVS AQHKASELET PASAQMLECK 


L 

« Hide

Isoform 2 [UniParc].

Checksum: 1332FF9533743412
Show »

FASTA26427,672

References

« Hide 'large scale' references
[1]"Cloning of a new aquaporin (AQP10) abundantly expressed in duodenum and jejunum."
Hatakeyama S., Yoshida Y., Tani T., Koyama Y., Nihei K., Ohshiro K., Kamiie J., Yaoita E., Suda T., Hatakeyama K., Yamamoto T.
Biochem. Biophys. Res. Commun. 287:814-819(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION.
Tissue: Jejunum.
[2]"Cloning and identification of a new member of water channel (AQP10) as an aquaglyceroporin."
Ishibashi K., Morinaga T., Kuwahara M., Sasaki S., Imai M.
Biochim. Biophys. Acta 1576:335-340(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION.
[3]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Lung.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF159174 mRNA. Translation: AAL25998.1.
AB066105 mRNA. Translation: BAB91223.1.
AL354980 Genomic DNA. Translation: CAH70482.1.
AL354980 Genomic DNA. Translation: CAH70483.1.
BC069607 mRNA. Translation: AAH69607.1.
BC074896 mRNA. Translation: AAH74896.1.
BC074897 mRNA. Translation: AAH74897.1.
PIRJC7772.
RefSeqNP_536354.2. NM_080429.2.
UniGeneHs.259048.

3D structure databases

ProteinModelPortalQ96PS8.
SMRQ96PS8. Positions 13-300.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000318355.

Chemistry

GuidetoPHARMACOLOGY697.

Protein family/group databases

TCDB1.A.8.9.5. the major intrinsic protein (mip) family.

Polymorphism databases

DMDM47117905.

Proteomic databases

PRIDEQ96PS8.

Protocols and materials databases

DNASU89872.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000324978; ENSP00000318355; ENSG00000143595. [Q96PS8-1]
ENST00000484864; ENSP00000420341; ENSG00000143595. [Q96PS8-2]
GeneID89872.
KEGGhsa:89872.
UCSCuc001feu.3. human. [Q96PS8-1]

Organism-specific databases

CTD89872.
GeneCardsGC01P154294.
HGNCHGNC:16029. AQP10.
MIM606578. gene.
neXtProtNX_Q96PS8.
PharmGKBPA24919.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0580.
HOGENOMHOG000288287.
HOVERGENHBG106057.
InParanoidQ96PS8.
KOK09878.
OMASAQMLEC.
OrthoDBEOG7J9VPP.
PhylomeDBQ96PS8.
TreeFamTF313173.

Enzyme and pathway databases

ReactomeREACT_15518. Transmembrane transport of small molecules.

Gene expression databases

BgeeQ96PS8.
CleanExHS_AQP10.
GenevestigatorQ96PS8.

Family and domain databases

Gene3D1.20.1080.10. 1 hit.
InterProIPR023271. Aquaporin-like.
IPR026252. Aquaporin_10.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERPTHR19139. PTHR19139. 1 hit.
PfamPF00230. MIP. 1 hit.
[Graphical view]
PRINTSPR02022. AQUAPORIN10M.
PR00783. MINTRINSICP.
SUPFAMSSF81338. SSF81338. 1 hit.
TIGRFAMsTIGR00861. MIP. 1 hit.
PROSITEPS00221. MIP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi89872.
NextBio76374.
PROQ96PS8.
SOURCESearch...

Entry information

Entry nameAQP10_HUMAN
AccessionPrimary (citable) accession number: Q96PS8
Secondary accession number(s): Q5VYD3, Q5VYD4, Q8NG70
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2002
Last sequence update: May 10, 2004
Last modified: March 19, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM