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Q96PR1 (KCNC2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Potassium voltage-gated channel subfamily C member 2
Alternative name(s):
Voltage-gated potassium channel Kv3.2
Gene names
Name:KCNC2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length638 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Channel properties are modulated by subunit assembly By similarity.

Subunit structure

The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming subunits that can associate with modulating accessory subunits. Interacts with KCNC1, KCNE1, KCNE2 and KCNE3 By similarity.

Subcellular location

Membrane; Multi-pass membrane protein.

Domain

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.

Sequence similarities

Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.2/KCNC2 sub-subfamily. [View classification]

Sequence caution

The sequence BAE06076.1 differs from that shown. Reason: Erroneous initiation.

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q96PR1-1)

Also known as: Kv3.2b;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q96PR1-2)

Also known as: Kv3.2d;

The sequence of this isoform differs from the canonical sequence as follows:
     594-638: GYEKSRSLNN...RSRSPIPSIL → VLYRIYHGLL...GNRLLLLNVP
Isoform 3 (identifier: Q96PR1-3)

Also known as: Kv3.2a;

The sequence of this isoform differs from the canonical sequence as follows:
     594-638: GYEKSRSLNNIAGLAGNALRLSPVTSPYNSPCPLRRSRSPIPSIL → DNCKEVVITGYTQAEARSLT
Isoform 4 (identifier: Q96PR1-4)

Also known as: Kv3.2c;

The sequence of this isoform differs from the canonical sequence as follows:
     539-558: VLSGDDSTGSEPPLSPPERL → DNCKEVVITGYTQAEARSLT
     559-638: Missing.
Isoform 5 (identifier: Q96PR1-5)

The sequence of this isoform differs from the canonical sequence as follows:
     539-593: Missing.
Note: No experimental confirmation available.
Isoform 6 (identifier: Q96PR1-6)

The sequence of this isoform differs from the canonical sequence as follows:
     595-638: YEKSRSLNNIAGLAGNALRLSPVTSPYNSPCPLRRSRSPIPSIL → IRNGHSILHHLDNGTKCHYLRIIF
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 638638Potassium voltage-gated channel subfamily C member 2
PRO_0000310416

Regions

Topological domain1 – 229229Cytoplasmic Potential
Transmembrane230 – 25021Helical; Name=Segment S1; Potential
Transmembrane284 – 30320Helical; Name=Segment S2; Potential
Topological domain304 – 31310Cytoplasmic Potential
Transmembrane314 – 33421Helical; Name=Segment S3; Potential
Transmembrane346 – 36823Helical; Voltage-sensor; Name=Segment S4; Potential
Topological domain369 – 38113Cytoplasmic Potential
Transmembrane382 – 40221Helical; Name=Segment S5; Potential
Transmembrane453 – 47321Helical; Name=Segment S6; Potential
Topological domain474 – 638165Cytoplasmic Potential
Region437 – 4426Selectivity filter By similarity
Compositional bias56 – 9944Gly/Pro-rich (insert)

Amino acid modifications

Glycosylation2591N-linked (GlcNAc...) Potential
Glycosylation2661N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence539 – 59355Missing in isoform 5.
VSP_044742
Alternative sequence539 – 55820VLSGD…PPERL → DNCKEVVITGYTQAEARSLT in isoform 4.
VSP_029269
Alternative sequence559 – 63880Missing in isoform 4.
VSP_029270
Alternative sequence594 – 63845GYEKS…IPSIL → VLYRIYHGLLTAEKGTVEFS HTKDYTGNRLLLLNVP in isoform 2.
VSP_029271
Alternative sequence594 – 63845GYEKS…IPSIL → DNCKEVVITGYTQAEARSLT in isoform 3.
VSP_029272
Alternative sequence595 – 63844YEKSR…IPSIL → IRNGHSILHHLDNGTKCHYL RIIF in isoform 6.
VSP_046002

Experimental info

Sequence conflict311G → V in AK309245. Ref.3
Sequence conflict3051P → S in BAE06076. Ref.4
Sequence conflict4761F → S in BAH11717. Ref.3
Sequence conflict4871Q → H in AK309245. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (Kv3.2b) [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 211CAF8395A58C5D

FASTA63870,226
        10         20         30         40         50         60 
MGKIENNERV ILNVGGTRHE TYRSTLKTLP GTRLALLASS EPPGDCLTTA GDKLQPSPPP 

        70         80         90        100        110        120 
LSPPPRAPPL SPGPGGCFEG GAGNCSSRGG RASDHPGGGR EFFFDRHPGV FAYVLNYYRT 

       130        140        150        160        170        180 
GKLHCPADVC GPLFEEELAF WGIDETDVEP CCWMTYRQHR DAEEALDIFE TPDLIGGDPG 

       190        200        210        220        230        240 
DDEDLAAKRL GIEDAAGLGG PDGKSGRWRR LQPRMWALFE DPYSSRAARF IAFASLFFIL 

       250        260        270        280        290        300 
VSITTFCLET HEAFNIVKNK TEPVINGTSV VLQYEIETDP ALTYVEGVCV VWFTFEFLVR 

       310        320        330        340        350        360 
IVFSPNKLEF IKNLLNIIDF VAILPFYLEV GLSGLSSKAA KDVLGFLRVV RFVRILRIFK 

       370        380        390        400        410        420 
LTRHFVGLRV LGHTLRASTN EFLLLIIFLA LGVLIFATMI YYAERVGAQP NDPSASEHTQ 

       430        440        450        460        470        480 
FKNIPIGFWW AVVTMTTLGY GDMYPQTWSG MLVGALCALA GVLTIAMPVP VIVNNFGMYY 

       490        500        510        520        530        540 
SLAMAKQKLP RKRKKHIPPA PQASSPTFCK TELNMACNST QSDTCLGKDN RLLEHNRSVL 

       550        560        570        580        590        600 
SGDDSTGSEP PLSPPERLPI RRSSTRDKNR RGETCFLLTT GDYTCASDGG IRKGYEKSRS 

       610        620        630 
LNNIAGLAGN ALRLSPVTSP YNSPCPLRRS RSPIPSIL 

« Hide

Isoform 2 (Kv3.2d) [UniParc].

Checksum: BDDBF6DB6FA0A510
Show »

FASTA62969,534
Isoform 3 (Kv3.2a) [UniParc].

Checksum: D6F4DA8E0659682D
Show »

FASTA61367,600
Isoform 4 (Kv3.2c) [UniParc].

Checksum: 86AC5B2DAF84AF1B
Show »

FASTA55861,650
Isoform 5 [UniParc].

Checksum: 65A3F7DFA2B7448D
Show »

FASTA58364,276
Isoform 6 [UniParc].

Checksum: 6C333D045C6325C1
Show »

FASTA61868,317

References

« Hide 'large scale' references
[1]"Localization of Shaw-related K+ channel genes on mouse and human chromosomes."
Haas M., Ward D.C., Lee J., Roses A.D., Clarke V., D'Eustachio P., Lau D., Vega-Saenz de Miera E., Rudy B.
Mamm. Genome 4:711-715(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3).
[2]Isbrandt D., Pongs O.
Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4; 5 AND 6).
Tissue: Amygdala and Thalamus.
[4]"Preparation of a set of expression-ready clones of mammalian long cDNAs encoding large proteins by the ORF trap cloning method."
Nakajima D., Saito K., Yamakawa H., Kikuno R.F., Nakayama M., Ohara R., Okazaki N., Koga H., Nagase T., Ohara O.
Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[5]"The finished DNA sequence of human chromosome 12."
Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. expand/collapse author list , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF268896 mRNA. Translation: AAL27272.1.
AF268897 mRNA. Translation: AAL27273.1.
AY243473 mRNA. Translation: AAO89503.1.
AY118169 mRNA. Translation: AAM81577.1.
AK094720 mRNA. Translation: BAC04407.1.
AK294269 mRNA. Translation: BAH11717.1.
AK309245 mRNA. No translation available.
AB209994 mRNA. Translation: BAE06076.1. Different initiation.
AC073525 Genomic DNA. No translation available.
AC091534 Genomic DNA. No translation available.
AC130405 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW97287.1.
CH471054 Genomic DNA. Translation: EAW97288.1.
CH471054 Genomic DNA. Translation: EAW97289.1.
CH471054 Genomic DNA. Translation: EAW97291.1.
BC093635 mRNA. Translation: AAH93635.1.
BC111991 mRNA. Translation: AAI11992.1.
RefSeqNP_001247426.1. NM_001260497.1.
NP_001247427.1. NM_001260498.1.
NP_001247428.1. NM_001260499.1.
NP_631874.1. NM_139136.3.
NP_631875.1. NM_139137.3.
NP_715624.1. NM_153748.2.
UniGeneHs.27214.
Hs.741918.

3D structure databases

ProteinModelPortalQ96PR1.
SMRQ96PR1. Positions 7-481.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109949. 1 interaction.
STRING9606.ENSP00000376966.

Chemistry

ChEMBLCHEMBL2362996.
GuidetoPHARMACOLOGY549.

PTM databases

PhosphoSiteQ96PR1.

Polymorphism databases

DMDM74752079.

Proteomic databases

PaxDbQ96PR1.
PRIDEQ96PR1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000298972; ENSP00000298972; ENSG00000166006. [Q96PR1-3]
ENST00000341669; ENSP00000340121; ENSG00000166006. [Q96PR1-2]
ENST00000350228; ENSP00000319877; ENSG00000166006. [Q96PR1-4]
ENST00000393288; ENSP00000376966; ENSG00000166006. [Q96PR1-6]
ENST00000540018; ENSP00000438423; ENSG00000166006. [Q96PR1-5]
ENST00000548513; ENSP00000449941; ENSG00000166006. [Q96PR1-3]
ENST00000549446; ENSP00000449253; ENSG00000166006. [Q96PR1-1]
ENST00000550433; ENSP00000448301; ENSG00000166006. [Q96PR1-2]
GeneID3747.
KEGGhsa:3747.
UCSCuc001sxe.4. human. [Q96PR1-3]
uc001sxf.4. human. [Q96PR1-4]
uc001sxg.2. human. [Q96PR1-1]
uc009zry.4. human. [Q96PR1-2]

Organism-specific databases

CTD3747.
GeneCardsGC12M075433.
HGNCHGNC:6234. KCNC2.
HPACAB022571.
HPA019664.
MIM176256. gene.
neXtProtNX_Q96PR1.
PharmGKBPA35490.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1226.
HOGENOMHOG000231012.
HOVERGENHBG105862.
InParanoidQ96PR1.
KOK04888.
OMAGNCSSHG.
OrthoDBEOG7CRTPP.
PhylomeDBQ96PR1.
TreeFamTF352511.

Enzyme and pathway databases

ReactomeREACT_111217. Metabolism.
REACT_13685. Neuronal System.

Gene expression databases

BgeeQ96PR1.
CleanExHS_KCNC2.
GenevestigatorQ96PR1.

Family and domain databases

Gene3D1.20.120.350. 1 hit.
3.30.710.10. 2 hits.
InterProIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003974. K_chnl_volt-dep_Kv3.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERPTHR11537. PTHR11537. 1 hit.
PfamPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSPR00169. KCHANNEL.
PR01491. KVCHANNEL.
PR01498. SHAWCHANNEL.
SMARTSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMSSF54695. SSF54695. 2 hits.
ProtoNetSearch...

Other

GeneWikiKCNC2.
GenomeRNAi3747.
NextBio14663.
PROQ96PR1.
SOURCESearch...

Entry information

Entry nameKCNC2_HUMAN
AccessionPrimary (citable) accession number: Q96PR1
Secondary accession number(s): B7Z231 expand/collapse secondary AC list , F5H030, J3KPP5, Q4LE77, Q86W09, Q8N1V9, Q96PR0
Entry history
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: December 1, 2001
Last modified: March 19, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM