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Q96PR1

- KCNC2_HUMAN

UniProt

Q96PR1 - KCNC2_HUMAN

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Protein
Potassium voltage-gated channel subfamily C member 2
Gene
KCNC2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Channel properties are modulated by subunit assembly By similarity.

GO - Molecular functioni

  1. delayed rectifier potassium channel activity Source: RefGenome

GO - Biological processi

  1. action potential Source: Ensembl
  2. energy reserve metabolic process Source: Reactome
  3. protein homooligomerization Source: InterPro
  4. regulation of insulin secretion Source: Reactome
  5. small molecule metabolic process Source: Reactome
  6. synaptic transmission Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_18274. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
REACT_75770. Voltage gated Potassium channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily C member 2
Alternative name(s):
Voltage-gated potassium channel Kv3.2
Gene namesi
Name:KCNC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:6234. KCNC2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 229229Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei230 – 25021Helical; Name=Segment S1; Reviewed prediction
Add
BLAST
Transmembranei284 – 30320Helical; Name=Segment S2; Reviewed prediction
Add
BLAST
Topological domaini304 – 31310Cytoplasmic Reviewed prediction
Transmembranei314 – 33421Helical; Name=Segment S3; Reviewed prediction
Add
BLAST
Transmembranei346 – 36823Helical; Voltage-sensor; Name=Segment S4; Reviewed prediction
Add
BLAST
Topological domaini369 – 38113Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei382 – 40221Helical; Name=Segment S5; Reviewed prediction
Add
BLAST
Transmembranei453 – 47321Helical; Name=Segment S6; Reviewed prediction
Add
BLAST
Topological domaini474 – 638165Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. plasma membrane Source: Reactome
  2. voltage-gated potassium channel complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35490.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 638638Potassium voltage-gated channel subfamily C member 2
PRO_0000310416Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi259 – 2591N-linked (GlcNAc...) Reviewed prediction
Glycosylationi266 – 2661N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ96PR1.
PRIDEiQ96PR1.

PTM databases

PhosphoSiteiQ96PR1.

Expressioni

Gene expression databases

BgeeiQ96PR1.
CleanExiHS_KCNC2.
GenevestigatoriQ96PR1.

Organism-specific databases

HPAiCAB022571.
HPA019664.

Interactioni

Subunit structurei

The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming subunits that can associate with modulating accessory subunits. Interacts with KCNC1, KCNE1, KCNE2 and KCNE3 By similarity.

Protein-protein interaction databases

BioGridi109949. 1 interaction.
STRINGi9606.ENSP00000376966.

Structurei

3D structure databases

ProteinModelPortaliQ96PR1.
SMRiQ96PR1. Positions 9-480.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni437 – 4426Selectivity filter By similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi56 – 9944Gly/Pro-rich (insert)
Add
BLAST

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1226.
HOGENOMiHOG000231012.
HOVERGENiHBG105862.
InParanoidiQ96PR1.
KOiK04888.
OMAiMCLGKDN.
OrthoDBiEOG7CRTPP.
PhylomeDBiQ96PR1.
TreeFamiTF352511.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
3.30.710.10. 2 hits.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003974. K_chnl_volt-dep_Kv3.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01491. KVCHANNEL.
PR01498. SHAWCHANNEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 2 hits.

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96PR1-1) [UniParc]FASTAAdd to Basket

Also known as: Kv3.2b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGKIENNERV ILNVGGTRHE TYRSTLKTLP GTRLALLASS EPPGDCLTTA    50
GDKLQPSPPP LSPPPRAPPL SPGPGGCFEG GAGNCSSRGG RASDHPGGGR 100
EFFFDRHPGV FAYVLNYYRT GKLHCPADVC GPLFEEELAF WGIDETDVEP 150
CCWMTYRQHR DAEEALDIFE TPDLIGGDPG DDEDLAAKRL GIEDAAGLGG 200
PDGKSGRWRR LQPRMWALFE DPYSSRAARF IAFASLFFIL VSITTFCLET 250
HEAFNIVKNK TEPVINGTSV VLQYEIETDP ALTYVEGVCV VWFTFEFLVR 300
IVFSPNKLEF IKNLLNIIDF VAILPFYLEV GLSGLSSKAA KDVLGFLRVV 350
RFVRILRIFK LTRHFVGLRV LGHTLRASTN EFLLLIIFLA LGVLIFATMI 400
YYAERVGAQP NDPSASEHTQ FKNIPIGFWW AVVTMTTLGY GDMYPQTWSG 450
MLVGALCALA GVLTIAMPVP VIVNNFGMYY SLAMAKQKLP RKRKKHIPPA 500
PQASSPTFCK TELNMACNST QSDTCLGKDN RLLEHNRSVL SGDDSTGSEP 550
PLSPPERLPI RRSSTRDKNR RGETCFLLTT GDYTCASDGG IRKGYEKSRS 600
LNNIAGLAGN ALRLSPVTSP YNSPCPLRRS RSPIPSIL 638
Length:638
Mass (Da):70,226
Last modified:December 1, 2001 - v1
Checksum:i211CAF8395A58C5D
GO
Isoform 2 (identifier: Q96PR1-2) [UniParc]FASTAAdd to Basket

Also known as: Kv3.2d

The sequence of this isoform differs from the canonical sequence as follows:
     594-638: GYEKSRSLNN...RSRSPIPSIL → VLYRIYHGLL...GNRLLLLNVP

Show »
Length:629
Mass (Da):69,534
Checksum:iBDDBF6DB6FA0A510
GO
Isoform 3 (identifier: Q96PR1-3) [UniParc]FASTAAdd to Basket

Also known as: Kv3.2a

The sequence of this isoform differs from the canonical sequence as follows:
     594-638: GYEKSRSLNNIAGLAGNALRLSPVTSPYNSPCPLRRSRSPIPSIL → DNCKEVVITGYTQAEARSLT

Show »
Length:613
Mass (Da):67,600
Checksum:iD6F4DA8E0659682D
GO
Isoform 4 (identifier: Q96PR1-4) [UniParc]FASTAAdd to Basket

Also known as: Kv3.2c

The sequence of this isoform differs from the canonical sequence as follows:
     539-558: VLSGDDSTGSEPPLSPPERL → DNCKEVVITGYTQAEARSLT
     559-638: Missing.

Show »
Length:558
Mass (Da):61,650
Checksum:i86AC5B2DAF84AF1B
GO
Isoform 5 (identifier: Q96PR1-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     539-593: Missing.

Note: No experimental confirmation available.

Show »
Length:583
Mass (Da):64,276
Checksum:i65A3F7DFA2B7448D
GO
Isoform 6 (identifier: Q96PR1-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     595-638: YEKSRSLNNIAGLAGNALRLSPVTSPYNSPCPLRRSRSPIPSIL → IRNGHSILHHLDNGTKCHYLRIIF

Note: No experimental confirmation available.

Show »
Length:618
Mass (Da):68,317
Checksum:i6C333D045C6325C1
GO

Sequence cautioni

The sequence BAE06076.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei539 – 59355Missing in isoform 5.
VSP_044742Add
BLAST
Alternative sequencei539 – 55820VLSGD…PPERL → DNCKEVVITGYTQAEARSLT in isoform 4.
VSP_029269Add
BLAST
Alternative sequencei559 – 63880Missing in isoform 4.
VSP_029270Add
BLAST
Alternative sequencei594 – 63845GYEKS…IPSIL → VLYRIYHGLLTAEKGTVEFS HTKDYTGNRLLLLNVP in isoform 2.
VSP_029271Add
BLAST
Alternative sequencei594 – 63845GYEKS…IPSIL → DNCKEVVITGYTQAEARSLT in isoform 3.
VSP_029272Add
BLAST
Alternative sequencei595 – 63844YEKSR…IPSIL → IRNGHSILHHLDNGTKCHYL RIIF in isoform 6.
VSP_046002Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti31 – 311G → V in AK309245. 1 Publication
Sequence conflicti305 – 3051P → S in BAE06076. 1 Publication
Sequence conflicti476 – 4761F → S in BAH11717. 1 Publication
Sequence conflicti487 – 4871Q → H in AK309245. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF268896 mRNA. Translation: AAL27272.1.
AF268897 mRNA. Translation: AAL27273.1.
AY243473 mRNA. Translation: AAO89503.1.
AY118169 mRNA. Translation: AAM81577.1.
AK094720 mRNA. Translation: BAC04407.1.
AK294269 mRNA. Translation: BAH11717.1.
AK309245 mRNA. No translation available.
AB209994 mRNA. Translation: BAE06076.1. Different initiation.
AC073525 Genomic DNA. No translation available.
AC091534 Genomic DNA. No translation available.
AC130405 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW97287.1.
CH471054 Genomic DNA. Translation: EAW97288.1.
CH471054 Genomic DNA. Translation: EAW97289.1.
CH471054 Genomic DNA. Translation: EAW97291.1.
BC093635 mRNA. Translation: AAH93635.1.
BC111991 mRNA. Translation: AAI11992.1.
CCDSiCCDS58255.1. [Q96PR1-5]
CCDS58256.1. [Q96PR1-2]
CCDS58257.1. [Q96PR1-6]
CCDS9005.1. [Q96PR1-3]
CCDS9006.1. [Q96PR1-4]
CCDS9007.1. [Q96PR1-1]
RefSeqiNP_001247426.1. NM_001260497.1. [Q96PR1-6]
NP_001247427.1. NM_001260498.1. [Q96PR1-2]
NP_001247428.1. NM_001260499.1. [Q96PR1-5]
NP_631874.1. NM_139136.3. [Q96PR1-3]
NP_631875.1. NM_139137.3. [Q96PR1-1]
NP_715624.1. NM_153748.2. [Q96PR1-4]
XP_006719445.1. XM_006719382.1. [Q96PR1-3]
XP_006719452.1. XM_006719389.1. [Q96PR1-4]
UniGeneiHs.27214.
Hs.741918.

Genome annotation databases

EnsembliENST00000298972; ENSP00000298972; ENSG00000166006. [Q96PR1-3]
ENST00000341669; ENSP00000340121; ENSG00000166006. [Q96PR1-2]
ENST00000350228; ENSP00000319877; ENSG00000166006. [Q96PR1-4]
ENST00000393288; ENSP00000376966; ENSG00000166006. [Q96PR1-6]
ENST00000540018; ENSP00000438423; ENSG00000166006. [Q96PR1-5]
ENST00000548513; ENSP00000449941; ENSG00000166006. [Q96PR1-3]
ENST00000549446; ENSP00000449253; ENSG00000166006. [Q96PR1-1]
ENST00000550433; ENSP00000448301; ENSG00000166006. [Q96PR1-2]
GeneIDi3747.
KEGGihsa:3747.
UCSCiuc001sxe.4. human. [Q96PR1-3]
uc001sxf.4. human. [Q96PR1-4]
uc001sxg.2. human. [Q96PR1-1]
uc009zry.4. human. [Q96PR1-2]

Polymorphism databases

DMDMi74752079.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF268896 mRNA. Translation: AAL27272.1 .
AF268897 mRNA. Translation: AAL27273.1 .
AY243473 mRNA. Translation: AAO89503.1 .
AY118169 mRNA. Translation: AAM81577.1 .
AK094720 mRNA. Translation: BAC04407.1 .
AK294269 mRNA. Translation: BAH11717.1 .
AK309245 mRNA. No translation available.
AB209994 mRNA. Translation: BAE06076.1 . Different initiation.
AC073525 Genomic DNA. No translation available.
AC091534 Genomic DNA. No translation available.
AC130405 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW97287.1 .
CH471054 Genomic DNA. Translation: EAW97288.1 .
CH471054 Genomic DNA. Translation: EAW97289.1 .
CH471054 Genomic DNA. Translation: EAW97291.1 .
BC093635 mRNA. Translation: AAH93635.1 .
BC111991 mRNA. Translation: AAI11992.1 .
CCDSi CCDS58255.1. [Q96PR1-5 ]
CCDS58256.1. [Q96PR1-2 ]
CCDS58257.1. [Q96PR1-6 ]
CCDS9005.1. [Q96PR1-3 ]
CCDS9006.1. [Q96PR1-4 ]
CCDS9007.1. [Q96PR1-1 ]
RefSeqi NP_001247426.1. NM_001260497.1. [Q96PR1-6 ]
NP_001247427.1. NM_001260498.1. [Q96PR1-2 ]
NP_001247428.1. NM_001260499.1. [Q96PR1-5 ]
NP_631874.1. NM_139136.3. [Q96PR1-3 ]
NP_631875.1. NM_139137.3. [Q96PR1-1 ]
NP_715624.1. NM_153748.2. [Q96PR1-4 ]
XP_006719445.1. XM_006719382.1. [Q96PR1-3 ]
XP_006719452.1. XM_006719389.1. [Q96PR1-4 ]
UniGenei Hs.27214.
Hs.741918.

3D structure databases

ProteinModelPortali Q96PR1.
SMRi Q96PR1. Positions 9-480.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109949. 1 interaction.
STRINGi 9606.ENSP00000376966.

Chemistry

ChEMBLi CHEMBL2362996.
GuidetoPHARMACOLOGYi 549.

PTM databases

PhosphoSitei Q96PR1.

Polymorphism databases

DMDMi 74752079.

Proteomic databases

PaxDbi Q96PR1.
PRIDEi Q96PR1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000298972 ; ENSP00000298972 ; ENSG00000166006 . [Q96PR1-3 ]
ENST00000341669 ; ENSP00000340121 ; ENSG00000166006 . [Q96PR1-2 ]
ENST00000350228 ; ENSP00000319877 ; ENSG00000166006 . [Q96PR1-4 ]
ENST00000393288 ; ENSP00000376966 ; ENSG00000166006 . [Q96PR1-6 ]
ENST00000540018 ; ENSP00000438423 ; ENSG00000166006 . [Q96PR1-5 ]
ENST00000548513 ; ENSP00000449941 ; ENSG00000166006 . [Q96PR1-3 ]
ENST00000549446 ; ENSP00000449253 ; ENSG00000166006 . [Q96PR1-1 ]
ENST00000550433 ; ENSP00000448301 ; ENSG00000166006 . [Q96PR1-2 ]
GeneIDi 3747.
KEGGi hsa:3747.
UCSCi uc001sxe.4. human. [Q96PR1-3 ]
uc001sxf.4. human. [Q96PR1-4 ]
uc001sxg.2. human. [Q96PR1-1 ]
uc009zry.4. human. [Q96PR1-2 ]

Organism-specific databases

CTDi 3747.
GeneCardsi GC12M075433.
HGNCi HGNC:6234. KCNC2.
HPAi CAB022571.
HPA019664.
MIMi 176256. gene.
neXtProti NX_Q96PR1.
PharmGKBi PA35490.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1226.
HOGENOMi HOG000231012.
HOVERGENi HBG105862.
InParanoidi Q96PR1.
KOi K04888.
OMAi MCLGKDN.
OrthoDBi EOG7CRTPP.
PhylomeDBi Q96PR1.
TreeFami TF352511.

Enzyme and pathway databases

Reactomei REACT_18274. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
REACT_75770. Voltage gated Potassium channels.

Miscellaneous databases

GeneWikii KCNC2.
GenomeRNAii 3747.
NextBioi 14663.
PROi Q96PR1.
SOURCEi Search...

Gene expression databases

Bgeei Q96PR1.
CleanExi HS_KCNC2.
Genevestigatori Q96PR1.

Family and domain databases

Gene3Di 1.20.120.350. 1 hit.
3.30.710.10. 2 hits.
InterProi IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003974. K_chnl_volt-dep_Kv3.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view ]
PANTHERi PTHR11537. PTHR11537. 1 hit.
Pfami PF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view ]
PRINTSi PR00169. KCHANNEL.
PR01491. KVCHANNEL.
PR01498. SHAWCHANNEL.
SMARTi SM00225. BTB. 1 hit.
[Graphical view ]
SUPFAMi SSF54695. SSF54695. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Localization of Shaw-related K+ channel genes on mouse and human chromosomes."
    Haas M., Ward D.C., Lee J., Roses A.D., Clarke V., D'Eustachio P., Lau D., Vega-Saenz de Miera E., Rudy B.
    Mamm. Genome 4:711-715(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3).
  2. Isbrandt D., Pongs O.
    Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4; 5 AND 6).
    Tissue: Amygdala and Thalamus.
  4. "Preparation of a set of expression-ready clones of mammalian long cDNAs encoding large proteins by the ORF trap cloning method."
    Nakajima D., Saito K., Yamakawa H., Kikuno R.F., Nakayama M., Ohara R., Okazaki N., Koga H., Nagase T., Ohara O.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  5. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Brain.

Entry informationi

Entry nameiKCNC2_HUMAN
AccessioniPrimary (citable) accession number: Q96PR1
Secondary accession number(s): B7Z231
, F5H030, J3KPP5, Q4LE77, Q86W09, Q8N1V9, Q96PR0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: December 1, 2001
Last modified: September 3, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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