Q96PR1 (KCNC2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Potassium voltage-gated channel subfamily C member 2

Alternative name(s):
Voltage-gated potassium channel Kv3.2

Gene names

Name:

KCNC2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	638 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Channel properties are modulated by subunit assembly By similarity.
Subunit structure	The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming subunits that can associate with modulating accessory subunits. Interacts with KCNC1, KCNE1, KCNE2 and KCNE3 By similarity.
Subcellular location	Membrane; Multi-pass membrane protein.
Domain	The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
Sequence similarities	Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.2/KCNC2 sub-subfamily. [View classification]
Sequence caution	The sequence BAE06076.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Ion transport Potassium transport Transport
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane Transmembrane helix
Ligand	Potassium
Molecular function	Ionic channel Potassium channel Voltage-gated channel
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	energy reserve metabolic process Traceable author statement. Source: Reactome regulation of insulin secretion Traceable author statement. Source: Reactome synaptic transmission Traceable author statement. Source: Reactome
Cellular component	voltage-gated potassium channel complex Inferred from electronic annotation. Source: InterPro
Molecular function	voltage-gated potassium channel activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96PR1-1)

Also known as: Kv3.2b;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96PR1-2)

Also known as: Kv3.2d;

The sequence of this isoform differs from the canonical sequence as follows:
     594-638: GYEKSRSLNN...RSRSPIPSIL → VLYRIYHGLL...GNRLLLLNVP

Isoform 3 (identifier: Q96PR1-3)

Also known as: Kv3.2a;

The sequence of this isoform differs from the canonical sequence as follows:
     594-638: GYEKSRSLNNIAGLAGNALRLSPVTSPYNSPCPLRRSRSPIPSIL → DNCKEVVITGYTQAEARSLT

Isoform 4 (identifier: Q96PR1-4)

Also known as: Kv3.2c;

The sequence of this isoform differs from the canonical sequence as follows:
     539-558: VLSGDDSTGSEPPLSPPERL → DNCKEVVITGYTQAEARSLT
     559-638: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 638	638	Potassium voltage-gated channel subfamily C member 2		PRO_0000310416
Regions
	Topological domain	1 – 229	229	Cytoplasmic Potential
	Transmembrane	230 – 250	21	Helical; Name=Segment S1; Potential
	Transmembrane	284 – 303	20	Helical; Name=Segment S2; Potential
	Topological domain	304 – 313	10	Cytoplasmic Potential
	Transmembrane	314 – 334	21	Helical; Name=Segment S3; Potential
	Transmembrane	346 – 368	23	Helical; Voltage-sensor; Name=Segment S4; Potential
	Topological domain	369 – 381	13	Cytoplasmic Potential
	Transmembrane	382 – 402	21	Helical; Name=Segment S5; Potential
	Transmembrane	453 – 473	21	Helical; Name=Segment S6; Potential
	Topological domain	474 – 638	165	Cytoplasmic Potential
	Region	437 – 442	6	Selectivity filter By similarity
	Compositional bias	56 – 99	44	Gly/Pro-rich (insert)
Amino acid modifications
	Glycosylation	259	1	N-linked (GlcNAc...) Potential
	Glycosylation	266	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	539 – 558	20	VLSGD…PPERL → DNCKEVVITGYTQAEARSLT in isoform 4.		VSP_029269
	Alternative sequence	559 – 638	80	Missing in isoform 4.		VSP_029270
	Alternative sequence	594 – 638	45	GYEKS…IPSIL → VLYRIYHGLLTAEKGTVEFS HTKDYTGNRLLLLNVP in isoform 2.		VSP_029271
	Alternative sequence	594 – 638	45	GYEKS…IPSIL → DNCKEVVITGYTQAEARSLT in isoform 3.		VSP_029272
Experimental info
	Sequence conflict	305	1	P → S in BAE06076. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Kv3.2b) [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 211CAF8395A58C5D	FASTA	638	70,226
	10 20 30 40 50 60 MGKIENNERV ILNVGGTRHE TYRSTLKTLP GTRLALLASS EPPGDCLTTA GDKLQPSPPP 70 80 90 100 110 120 LSPPPRAPPL SPGPGGCFEG GAGNCSSRGG RASDHPGGGR EFFFDRHPGV FAYVLNYYRT 130 140 150 160 170 180 GKLHCPADVC GPLFEEELAF WGIDETDVEP CCWMTYRQHR DAEEALDIFE TPDLIGGDPG 190 200 210 220 230 240 DDEDLAAKRL GIEDAAGLGG PDGKSGRWRR LQPRMWALFE DPYSSRAARF IAFASLFFIL 250 260 270 280 290 300 VSITTFCLET HEAFNIVKNK TEPVINGTSV VLQYEIETDP ALTYVEGVCV VWFTFEFLVR 310 320 330 340 350 360 IVFSPNKLEF IKNLLNIIDF VAILPFYLEV GLSGLSSKAA KDVLGFLRVV RFVRILRIFK 370 380 390 400 410 420 LTRHFVGLRV LGHTLRASTN EFLLLIIFLA LGVLIFATMI YYAERVGAQP NDPSASEHTQ 430 440 450 460 470 480 FKNIPIGFWW AVVTMTTLGY GDMYPQTWSG MLVGALCALA GVLTIAMPVP VIVNNFGMYY 490 500 510 520 530 540 SLAMAKQKLP RKRKKHIPPA PQASSPTFCK TELNMACNST QSDTCLGKDN RLLEHNRSVL 550 560 570 580 590 600 SGDDSTGSEP PLSPPERLPI RRSSTRDKNR RGETCFLLTT GDYTCASDGG IRKGYEKSRS 610 620 630 LNNIAGLAGN ALRLSPVTSP YNSPCPLRRS RSPIPSIL
	Isoform 2 (Kv3.2d) [UniParc]. Checksum: BDDBF6DB6FA0A510	FASTA	629	69,534
	10 20 30 40 50 60 MGKIENNERV ILNVGGTRHE TYRSTLKTLP GTRLALLASS EPPGDCLTTA GDKLQPSPPP 70 80 90 100 110 120 LSPPPRAPPL SPGPGGCFEG GAGNCSSRGG RASDHPGGGR EFFFDRHPGV FAYVLNYYRT 130 140 150 160 170 180 GKLHCPADVC GPLFEEELAF WGIDETDVEP CCWMTYRQHR DAEEALDIFE TPDLIGGDPG 190 200 210 220 230 240 DDEDLAAKRL GIEDAAGLGG PDGKSGRWRR LQPRMWALFE DPYSSRAARF IAFASLFFIL 250 260 270 280 290 300 VSITTFCLET HEAFNIVKNK TEPVINGTSV VLQYEIETDP ALTYVEGVCV VWFTFEFLVR 310 320 330 340 350 360 IVFSPNKLEF IKNLLNIIDF VAILPFYLEV GLSGLSSKAA KDVLGFLRVV RFVRILRIFK 370 380 390 400 410 420 LTRHFVGLRV LGHTLRASTN EFLLLIIFLA LGVLIFATMI YYAERVGAQP NDPSASEHTQ 430 440 450 460 470 480 FKNIPIGFWW AVVTMTTLGY GDMYPQTWSG MLVGALCALA GVLTIAMPVP VIVNNFGMYY 490 500 510 520 530 540 SLAMAKQKLP RKRKKHIPPA PQASSPTFCK TELNMACNST QSDTCLGKDN RLLEHNRSVL 550 560 570 580 590 600 SGDDSTGSEP PLSPPERLPI RRSSTRDKNR RGETCFLLTT GDYTCASDGG IRKVLYRIYH 610 620 GLLTAEKGTV EFSHTKDYTG NRLLLLNVP
	Isoform 3 (Kv3.2a) [UniParc]. Checksum: D6F4DA8E0659682D	FASTA	613	67,600
	10 20 30 40 50 60 MGKIENNERV ILNVGGTRHE TYRSTLKTLP GTRLALLASS EPPGDCLTTA GDKLQPSPPP 70 80 90 100 110 120 LSPPPRAPPL SPGPGGCFEG GAGNCSSRGG RASDHPGGGR EFFFDRHPGV FAYVLNYYRT 130 140 150 160 170 180 GKLHCPADVC GPLFEEELAF WGIDETDVEP CCWMTYRQHR DAEEALDIFE TPDLIGGDPG 190 200 210 220 230 240 DDEDLAAKRL GIEDAAGLGG PDGKSGRWRR LQPRMWALFE DPYSSRAARF IAFASLFFIL 250 260 270 280 290 300 VSITTFCLET HEAFNIVKNK TEPVINGTSV VLQYEIETDP ALTYVEGVCV VWFTFEFLVR 310 320 330 340 350 360 IVFSPNKLEF IKNLLNIIDF VAILPFYLEV GLSGLSSKAA KDVLGFLRVV RFVRILRIFK 370 380 390 400 410 420 LTRHFVGLRV LGHTLRASTN EFLLLIIFLA LGVLIFATMI YYAERVGAQP NDPSASEHTQ 430 440 450 460 470 480 FKNIPIGFWW AVVTMTTLGY GDMYPQTWSG MLVGALCALA GVLTIAMPVP VIVNNFGMYY 490 500 510 520 530 540 SLAMAKQKLP RKRKKHIPPA PQASSPTFCK TELNMACNST QSDTCLGKDN RLLEHNRSVL 550 560 570 580 590 600 SGDDSTGSEP PLSPPERLPI RRSSTRDKNR RGETCFLLTT GDYTCASDGG IRKDNCKEVV 610 ITGYTQAEAR SLT
	Isoform 4 (Kv3.2c) [UniParc]. Checksum: 86AC5B2DAF84AF1B	FASTA	558	61,650
	10 20 30 40 50 60 MGKIENNERV ILNVGGTRHE TYRSTLKTLP GTRLALLASS EPPGDCLTTA GDKLQPSPPP 70 80 90 100 110 120 LSPPPRAPPL SPGPGGCFEG GAGNCSSRGG RASDHPGGGR EFFFDRHPGV FAYVLNYYRT 130 140 150 160 170 180 GKLHCPADVC GPLFEEELAF WGIDETDVEP CCWMTYRQHR DAEEALDIFE TPDLIGGDPG 190 200 210 220 230 240 DDEDLAAKRL GIEDAAGLGG PDGKSGRWRR LQPRMWALFE DPYSSRAARF IAFASLFFIL 250 260 270 280 290 300 VSITTFCLET HEAFNIVKNK TEPVINGTSV VLQYEIETDP ALTYVEGVCV VWFTFEFLVR 310 320 330 340 350 360 IVFSPNKLEF IKNLLNIIDF VAILPFYLEV GLSGLSSKAA KDVLGFLRVV RFVRILRIFK 370 380 390 400 410 420 LTRHFVGLRV LGHTLRASTN EFLLLIIFLA LGVLIFATMI YYAERVGAQP NDPSASEHTQ 430 440 450 460 470 480 FKNIPIGFWW AVVTMTTLGY GDMYPQTWSG MLVGALCALA GVLTIAMPVP VIVNNFGMYY 490 500 510 520 530 540 SLAMAKQKLP RKRKKHIPPA PQASSPTFCK TELNMACNST QSDTCLGKDN RLLEHNRSDN 550 CKEVVITGYT QAEARSLT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Localization of Shaw-related K+ channel genes on mouse and human chromosomes." Haas M., Ward D.C., Lee J., Roses A.D., Clarke V., D'Eustachio P., Lau D., Vega-Saenz de Miera E., Rudy B. Mamm. Genome 4:711-715(1993) [PubMed: 8111118] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3).
[2]	Isbrandt D., Pongs O. Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Amygdala.
[4]	"Preparation of a set of expression-ready clones of mammalian long cDNAs encoding large proteins by the ORF trap cloning method." Nakajima D., Saito K., Yamakawa H., Kikuno R.F., Nakayama M., Ohara R., Okazaki N., Koga H., Nagase T., Ohara O. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF268896 mRNA. Translation: AAL27272.1. AF268897 mRNA. Translation: AAL27273.1. AY243473 mRNA. Translation: AAO89503.1. AY118169 mRNA. Translation: AAM81577.1. AK094720 mRNA. Translation: BAC04407.1. AB209994 mRNA. Translation: BAE06076.1. Different initiation. CH471054 Genomic DNA. Translation: EAW97287.1. CH471054 Genomic DNA. Translation: EAW97288.1. CH471054 Genomic DNA. Translation: EAW97289.1. CH471054 Genomic DNA. Translation: EAW97291.1. BC093635 mRNA. Translation: AAH93635.1. BC111991 mRNA. Translation: AAI11992.1.
IPI	IPI00162733. IPI00221367. IPI00790384. IPI01011210.
RefSeq	NP_631874.1. NM_139136.2. NP_631875.1. NM_139137.2. NP_715624.1. NM_153748.1.
UniGene	Hs.27214.
3D structure databases
HSSP	HSSP built from PDB template 2A79 based on UniProtKB P63142.
ProteinModelPortal	Q96PR1.
SMR	Q96PR1. Positions 7-482.
ModBase	Search...
Protein-protein interaction databases
STRING	Q96PR1.
PTM databases
PhosphoSite	Q96PR1.
Polymorphism databases
DMDM	74752079.
Proteomic databases
PRIDE	Q96PR1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000393288; ENSP00000376966; ENSG00000166006.
GeneID	3747.
KEGG	hsa:3747.
UCSC	uc001sxe.1. human. uc001sxf.1. human. uc001sxg.1. human. uc009zry.1. human.
Organism-specific databases
CTD	3747.
GeneCards	GC12M075433.
HGNC	HGNC:6234. KCNC2.
HPA	CAB022571. HPA019664.
MIM	176256. gene.
neXtProt	NX_Q96PR1.
PharmGKB	PA35490.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG10322.
GeneTree	ENSGT00580000081499.
HOGENOM	HBG445693.
HOVERGEN	HBG105862.
InParanoid	Q96PR1.
OMA	LLDHNRS.
OrthoDB	EOG4JQ3X8.
PhylomeDB	Q96PR1.
Enzyme and pathway databases
Reactome	REACT_111217. Metabolism. REACT_13685. Neuronal System.
Gene expression databases
ArrayExpress	Q96PR1.
Bgee	Q96PR1.
CleanEx	HS_KCNC2.
Genevestigator	Q96PR1.
Family and domain databases
InterPro	IPR000210. BTB/POZ-like. IPR011333. BTB/POZ_fold. IPR005821. Ion_trans. IPR003091. K_chnl. IPR003968. K_chnl_volt-dep_Kv. IPR003974. K_chnl_volt-dep_Kv3. IPR003131. K_chnl_volt-dep_Kv_tetra. [Graphical view]
Gene3D	G3DSA:3.30.710.10. BTB/POZ_fold. 2 hits.
KO	K04888.
Pfam	PF00520. Ion_trans. 1 hit. PF02214. K_tetra. 1 hit. [Graphical view]
PRINTS	PR00169. KCHANNEL. PR01491. KVCHANNEL. PR01498. SHAWCHANNEL.
SMART	SM00225. BTB. 1 hit. [Graphical view]
SUPFAM	SSF54695. BTB/POZ_fold. 1 hit.
ProtoNet	Search...
Other
NextBio	14663.
SOURCE	Search...

Entry information

Entry name

KCNC2_HUMAN

Accession

Primary (citable) accession number: Q96PR1
Secondary accession number(s): Q4LE77 , Q86W09, Q8N1V9, Q96PR0

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 13, 2007
Last sequence update:	December 1, 2001
Last modified:	January 25, 2012
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.