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Q96PR1

- KCNC2_HUMAN

UniProt

Q96PR1 - KCNC2_HUMAN

Protein

Potassium voltage-gated channel subfamily C member 2

Gene

KCNC2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Channel properties are modulated by subunit assembly By similarity.By similarity

    GO - Molecular functioni

    1. delayed rectifier potassium channel activity Source: RefGenome

    GO - Biological processi

    1. action potential Source: Ensembl
    2. energy reserve metabolic process Source: Reactome
    3. protein homooligomerization Source: InterPro
    4. regulation of insulin secretion Source: Reactome
    5. small molecule metabolic process Source: Reactome
    6. synaptic transmission Source: Reactome

    Keywords - Molecular functioni

    Ion channel, Potassium channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Potassium

    Enzyme and pathway databases

    ReactomeiREACT_18274. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
    REACT_75770. Voltage gated Potassium channels.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium voltage-gated channel subfamily C member 2
    Alternative name(s):
    Voltage-gated potassium channel Kv3.2
    Gene namesi
    Name:KCNC2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:6234. KCNC2.

    Subcellular locationi

    GO - Cellular componenti

    1. plasma membrane Source: Reactome
    2. voltage-gated potassium channel complex Source: InterPro

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35490.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 638638Potassium voltage-gated channel subfamily C member 2PRO_0000310416Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi259 – 2591N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi266 – 2661N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ96PR1.
    PRIDEiQ96PR1.

    PTM databases

    PhosphoSiteiQ96PR1.

    Expressioni

    Gene expression databases

    BgeeiQ96PR1.
    CleanExiHS_KCNC2.
    GenevestigatoriQ96PR1.

    Organism-specific databases

    HPAiCAB022571.
    HPA019664.

    Interactioni

    Subunit structurei

    The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming subunits that can associate with modulating accessory subunits. Interacts with KCNC1, KCNE1, KCNE2 and KCNE3 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi109949. 1 interaction.
    STRINGi9606.ENSP00000376966.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96PR1.
    SMRiQ96PR1. Positions 9-480.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 229229CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini304 – 31310CytoplasmicSequence Analysis
    Topological domaini369 – 38113CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini474 – 638165CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei230 – 25021Helical; Name=Segment S1Sequence AnalysisAdd
    BLAST
    Transmembranei284 – 30320Helical; Name=Segment S2Sequence AnalysisAdd
    BLAST
    Transmembranei314 – 33421Helical; Name=Segment S3Sequence AnalysisAdd
    BLAST
    Transmembranei346 – 36823Helical; Voltage-sensor; Name=Segment S4Sequence AnalysisAdd
    BLAST
    Transmembranei382 – 40221Helical; Name=Segment S5Sequence AnalysisAdd
    BLAST
    Transmembranei453 – 47321Helical; Name=Segment S6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni437 – 4426Selectivity filterBy similarity

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi56 – 9944Gly/Pro-rich (insert)Add
    BLAST

    Domaini

    The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
    The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1226.
    HOGENOMiHOG000231012.
    HOVERGENiHBG105862.
    InParanoidiQ96PR1.
    KOiK04888.
    OMAiMCLGKDN.
    OrthoDBiEOG7CRTPP.
    PhylomeDBiQ96PR1.
    TreeFamiTF352511.

    Family and domain databases

    Gene3Di1.20.120.350. 1 hit.
    3.30.710.10. 2 hits.
    InterProiIPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR003091. K_chnl.
    IPR003968. K_chnl_volt-dep_Kv.
    IPR003974. K_chnl_volt-dep_Kv3.
    IPR003131. T1-type_BTB.
    IPR028325. VG_K_chnl.
    [Graphical view]
    PANTHERiPTHR11537. PTHR11537. 1 hit.
    PfamiPF02214. BTB_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view]
    PRINTSiPR00169. KCHANNEL.
    PR01491. KVCHANNEL.
    PR01498. SHAWCHANNEL.
    SMARTiSM00225. BTB. 1 hit.
    [Graphical view]
    SUPFAMiSSF54695. SSF54695. 2 hits.

    Sequences (6)i

    Sequence statusi: Complete.

    This entry describes 6 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96PR1-1) [UniParc]FASTAAdd to Basket

    Also known as: Kv3.2b

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGKIENNERV ILNVGGTRHE TYRSTLKTLP GTRLALLASS EPPGDCLTTA    50
    GDKLQPSPPP LSPPPRAPPL SPGPGGCFEG GAGNCSSRGG RASDHPGGGR 100
    EFFFDRHPGV FAYVLNYYRT GKLHCPADVC GPLFEEELAF WGIDETDVEP 150
    CCWMTYRQHR DAEEALDIFE TPDLIGGDPG DDEDLAAKRL GIEDAAGLGG 200
    PDGKSGRWRR LQPRMWALFE DPYSSRAARF IAFASLFFIL VSITTFCLET 250
    HEAFNIVKNK TEPVINGTSV VLQYEIETDP ALTYVEGVCV VWFTFEFLVR 300
    IVFSPNKLEF IKNLLNIIDF VAILPFYLEV GLSGLSSKAA KDVLGFLRVV 350
    RFVRILRIFK LTRHFVGLRV LGHTLRASTN EFLLLIIFLA LGVLIFATMI 400
    YYAERVGAQP NDPSASEHTQ FKNIPIGFWW AVVTMTTLGY GDMYPQTWSG 450
    MLVGALCALA GVLTIAMPVP VIVNNFGMYY SLAMAKQKLP RKRKKHIPPA 500
    PQASSPTFCK TELNMACNST QSDTCLGKDN RLLEHNRSVL SGDDSTGSEP 550
    PLSPPERLPI RRSSTRDKNR RGETCFLLTT GDYTCASDGG IRKGYEKSRS 600
    LNNIAGLAGN ALRLSPVTSP YNSPCPLRRS RSPIPSIL 638
    Length:638
    Mass (Da):70,226
    Last modified:December 1, 2001 - v1
    Checksum:i211CAF8395A58C5D
    GO
    Isoform 2 (identifier: Q96PR1-2) [UniParc]FASTAAdd to Basket

    Also known as: Kv3.2d

    The sequence of this isoform differs from the canonical sequence as follows:
         594-638: GYEKSRSLNN...RSRSPIPSIL → VLYRIYHGLL...GNRLLLLNVP

    Show »
    Length:629
    Mass (Da):69,534
    Checksum:iBDDBF6DB6FA0A510
    GO
    Isoform 3 (identifier: Q96PR1-3) [UniParc]FASTAAdd to Basket

    Also known as: Kv3.2a

    The sequence of this isoform differs from the canonical sequence as follows:
         594-638: GYEKSRSLNNIAGLAGNALRLSPVTSPYNSPCPLRRSRSPIPSIL → DNCKEVVITGYTQAEARSLT

    Show »
    Length:613
    Mass (Da):67,600
    Checksum:iD6F4DA8E0659682D
    GO
    Isoform 4 (identifier: Q96PR1-4) [UniParc]FASTAAdd to Basket

    Also known as: Kv3.2c

    The sequence of this isoform differs from the canonical sequence as follows:
         539-558: VLSGDDSTGSEPPLSPPERL → DNCKEVVITGYTQAEARSLT
         559-638: Missing.

    Show »
    Length:558
    Mass (Da):61,650
    Checksum:i86AC5B2DAF84AF1B
    GO
    Isoform 5 (identifier: Q96PR1-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         539-593: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:583
    Mass (Da):64,276
    Checksum:i65A3F7DFA2B7448D
    GO
    Isoform 6 (identifier: Q96PR1-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         595-638: YEKSRSLNNIAGLAGNALRLSPVTSPYNSPCPLRRSRSPIPSIL → IRNGHSILHHLDNGTKCHYLRIIF

    Note: No experimental confirmation available.

    Show »
    Length:618
    Mass (Da):68,317
    Checksum:i6C333D045C6325C1
    GO

    Sequence cautioni

    The sequence BAE06076.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti31 – 311G → V in AK309245. (PubMed:14702039)Curated
    Sequence conflicti305 – 3051P → S in BAE06076. 1 PublicationCurated
    Sequence conflicti476 – 4761F → S in BAH11717. (PubMed:14702039)Curated
    Sequence conflicti487 – 4871Q → H in AK309245. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei539 – 59355Missing in isoform 5. 1 PublicationVSP_044742Add
    BLAST
    Alternative sequencei539 – 55820VLSGD…PPERL → DNCKEVVITGYTQAEARSLT in isoform 4. 2 PublicationsVSP_029269Add
    BLAST
    Alternative sequencei559 – 63880Missing in isoform 4. 2 PublicationsVSP_029270Add
    BLAST
    Alternative sequencei594 – 63845GYEKS…IPSIL → VLYRIYHGLLTAEKGTVEFS HTKDYTGNRLLLLNVP in isoform 2. 1 PublicationVSP_029271Add
    BLAST
    Alternative sequencei594 – 63845GYEKS…IPSIL → DNCKEVVITGYTQAEARSLT in isoform 3. 1 PublicationVSP_029272Add
    BLAST
    Alternative sequencei595 – 63844YEKSR…IPSIL → IRNGHSILHHLDNGTKCHYL RIIF in isoform 6. 1 PublicationVSP_046002Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF268896 mRNA. Translation: AAL27272.1.
    AF268897 mRNA. Translation: AAL27273.1.
    AY243473 mRNA. Translation: AAO89503.1.
    AY118169 mRNA. Translation: AAM81577.1.
    AK094720 mRNA. Translation: BAC04407.1.
    AK294269 mRNA. Translation: BAH11717.1.
    AK309245 mRNA. No translation available.
    AB209994 mRNA. Translation: BAE06076.1. Different initiation.
    AC073525 Genomic DNA. No translation available.
    AC091534 Genomic DNA. No translation available.
    AC130405 Genomic DNA. No translation available.
    CH471054 Genomic DNA. Translation: EAW97287.1.
    CH471054 Genomic DNA. Translation: EAW97288.1.
    CH471054 Genomic DNA. Translation: EAW97289.1.
    CH471054 Genomic DNA. Translation: EAW97291.1.
    BC093635 mRNA. Translation: AAH93635.1.
    BC111991 mRNA. Translation: AAI11992.1.
    CCDSiCCDS58255.1. [Q96PR1-5]
    CCDS58256.1. [Q96PR1-2]
    CCDS58257.1. [Q96PR1-6]
    CCDS9005.1. [Q96PR1-3]
    CCDS9006.1. [Q96PR1-4]
    CCDS9007.1. [Q96PR1-1]
    RefSeqiNP_001247426.1. NM_001260497.1. [Q96PR1-6]
    NP_001247427.1. NM_001260498.1. [Q96PR1-2]
    NP_001247428.1. NM_001260499.1. [Q96PR1-5]
    NP_631874.1. NM_139136.3. [Q96PR1-3]
    NP_631875.1. NM_139137.3. [Q96PR1-1]
    NP_715624.1. NM_153748.2. [Q96PR1-4]
    XP_006719445.1. XM_006719382.1. [Q96PR1-3]
    XP_006719452.1. XM_006719389.1. [Q96PR1-4]
    UniGeneiHs.27214.
    Hs.741918.

    Genome annotation databases

    EnsembliENST00000298972; ENSP00000298972; ENSG00000166006. [Q96PR1-3]
    ENST00000350228; ENSP00000319877; ENSG00000166006. [Q96PR1-4]
    ENST00000393288; ENSP00000376966; ENSG00000166006. [Q96PR1-6]
    ENST00000540018; ENSP00000438423; ENSG00000166006. [Q96PR1-5]
    ENST00000548513; ENSP00000449941; ENSG00000166006. [Q96PR1-3]
    ENST00000549446; ENSP00000449253; ENSG00000166006. [Q96PR1-1]
    ENST00000550433; ENSP00000448301; ENSG00000166006. [Q96PR1-2]
    GeneIDi3747.
    KEGGihsa:3747.
    UCSCiuc001sxe.4. human. [Q96PR1-3]
    uc001sxf.4. human. [Q96PR1-4]
    uc001sxg.2. human. [Q96PR1-1]
    uc009zry.4. human. [Q96PR1-2]

    Polymorphism databases

    DMDMi74752079.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF268896 mRNA. Translation: AAL27272.1 .
    AF268897 mRNA. Translation: AAL27273.1 .
    AY243473 mRNA. Translation: AAO89503.1 .
    AY118169 mRNA. Translation: AAM81577.1 .
    AK094720 mRNA. Translation: BAC04407.1 .
    AK294269 mRNA. Translation: BAH11717.1 .
    AK309245 mRNA. No translation available.
    AB209994 mRNA. Translation: BAE06076.1 . Different initiation.
    AC073525 Genomic DNA. No translation available.
    AC091534 Genomic DNA. No translation available.
    AC130405 Genomic DNA. No translation available.
    CH471054 Genomic DNA. Translation: EAW97287.1 .
    CH471054 Genomic DNA. Translation: EAW97288.1 .
    CH471054 Genomic DNA. Translation: EAW97289.1 .
    CH471054 Genomic DNA. Translation: EAW97291.1 .
    BC093635 mRNA. Translation: AAH93635.1 .
    BC111991 mRNA. Translation: AAI11992.1 .
    CCDSi CCDS58255.1. [Q96PR1-5 ]
    CCDS58256.1. [Q96PR1-2 ]
    CCDS58257.1. [Q96PR1-6 ]
    CCDS9005.1. [Q96PR1-3 ]
    CCDS9006.1. [Q96PR1-4 ]
    CCDS9007.1. [Q96PR1-1 ]
    RefSeqi NP_001247426.1. NM_001260497.1. [Q96PR1-6 ]
    NP_001247427.1. NM_001260498.1. [Q96PR1-2 ]
    NP_001247428.1. NM_001260499.1. [Q96PR1-5 ]
    NP_631874.1. NM_139136.3. [Q96PR1-3 ]
    NP_631875.1. NM_139137.3. [Q96PR1-1 ]
    NP_715624.1. NM_153748.2. [Q96PR1-4 ]
    XP_006719445.1. XM_006719382.1. [Q96PR1-3 ]
    XP_006719452.1. XM_006719389.1. [Q96PR1-4 ]
    UniGenei Hs.27214.
    Hs.741918.

    3D structure databases

    ProteinModelPortali Q96PR1.
    SMRi Q96PR1. Positions 9-480.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109949. 1 interaction.
    STRINGi 9606.ENSP00000376966.

    Chemistry

    ChEMBLi CHEMBL2362996.
    GuidetoPHARMACOLOGYi 549.

    PTM databases

    PhosphoSitei Q96PR1.

    Polymorphism databases

    DMDMi 74752079.

    Proteomic databases

    PaxDbi Q96PR1.
    PRIDEi Q96PR1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000298972 ; ENSP00000298972 ; ENSG00000166006 . [Q96PR1-3 ]
    ENST00000350228 ; ENSP00000319877 ; ENSG00000166006 . [Q96PR1-4 ]
    ENST00000393288 ; ENSP00000376966 ; ENSG00000166006 . [Q96PR1-6 ]
    ENST00000540018 ; ENSP00000438423 ; ENSG00000166006 . [Q96PR1-5 ]
    ENST00000548513 ; ENSP00000449941 ; ENSG00000166006 . [Q96PR1-3 ]
    ENST00000549446 ; ENSP00000449253 ; ENSG00000166006 . [Q96PR1-1 ]
    ENST00000550433 ; ENSP00000448301 ; ENSG00000166006 . [Q96PR1-2 ]
    GeneIDi 3747.
    KEGGi hsa:3747.
    UCSCi uc001sxe.4. human. [Q96PR1-3 ]
    uc001sxf.4. human. [Q96PR1-4 ]
    uc001sxg.2. human. [Q96PR1-1 ]
    uc009zry.4. human. [Q96PR1-2 ]

    Organism-specific databases

    CTDi 3747.
    GeneCardsi GC12M075433.
    HGNCi HGNC:6234. KCNC2.
    HPAi CAB022571.
    HPA019664.
    MIMi 176256. gene.
    neXtProti NX_Q96PR1.
    PharmGKBi PA35490.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1226.
    HOGENOMi HOG000231012.
    HOVERGENi HBG105862.
    InParanoidi Q96PR1.
    KOi K04888.
    OMAi MCLGKDN.
    OrthoDBi EOG7CRTPP.
    PhylomeDBi Q96PR1.
    TreeFami TF352511.

    Enzyme and pathway databases

    Reactomei REACT_18274. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
    REACT_75770. Voltage gated Potassium channels.

    Miscellaneous databases

    GeneWikii KCNC2.
    GenomeRNAii 3747.
    NextBioi 14663.
    PROi Q96PR1.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q96PR1.
    CleanExi HS_KCNC2.
    Genevestigatori Q96PR1.

    Family and domain databases

    Gene3Di 1.20.120.350. 1 hit.
    3.30.710.10. 2 hits.
    InterProi IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR003091. K_chnl.
    IPR003968. K_chnl_volt-dep_Kv.
    IPR003974. K_chnl_volt-dep_Kv3.
    IPR003131. T1-type_BTB.
    IPR028325. VG_K_chnl.
    [Graphical view ]
    PANTHERi PTHR11537. PTHR11537. 1 hit.
    Pfami PF02214. BTB_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view ]
    PRINTSi PR00169. KCHANNEL.
    PR01491. KVCHANNEL.
    PR01498. SHAWCHANNEL.
    SMARTi SM00225. BTB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54695. SSF54695. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Localization of Shaw-related K+ channel genes on mouse and human chromosomes."
      Haas M., Ward D.C., Lee J., Roses A.D., Clarke V., D'Eustachio P., Lau D., Vega-Saenz de Miera E., Rudy B.
      Mamm. Genome 4:711-715(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3).
    2. Isbrandt D., Pongs O.
      Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4; 5 AND 6).
      Tissue: Amygdala and Thalamus.
    4. "Preparation of a set of expression-ready clones of mammalian long cDNAs encoding large proteins by the ORF trap cloning method."
      Nakajima D., Saito K., Yamakawa H., Kikuno R.F., Nakayama M., Ohara R., Okazaki N., Koga H., Nagase T., Ohara O.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    5. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
      Tissue: Brain.

    Entry informationi

    Entry nameiKCNC2_HUMAN
    AccessioniPrimary (citable) accession number: Q96PR1
    Secondary accession number(s): B7Z231
    , F5H030, J3KPP5, Q4LE77, Q86W09, Q8N1V9, Q96PR0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 13, 2007
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3