Q96PR1 (KCNC2_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 80.
History...
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Potassium voltage-gated channel subfamily C member 2 Alternative name(s): Voltage-gated potassium channel Kv3.2 | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 638 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Channel properties are modulated by subunit assembly By similarity. |
| Subunit structure | The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming subunits that can associate with modulating accessory subunits. Interacts with KCNC1, KCNE1, KCNE2 and KCNE3 By similarity. |
| Subcellular location | |
| Domain | The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments. |
| Sequence similarities | Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.2/KCNC2 sub-subfamily. [View classification] |
| Sequence caution | The sequence BAE06076.1 differs from that shown. Reason: Erroneous initiation. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Ion transport Potassium transport Transport |
| Cellular component | Membrane |
| Coding sequence diversity | Alternative splicing |
| Domain | Transmembrane Transmembrane helix |
| Ligand | Potassium |
| Molecular function | Ionic channel Potassium channel Voltage-gated channel |
| PTM | Glycoprotein |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | energy reserve metabolic process Traceable author statement. Source: Reactome regulation of insulin secretionTraceable author statement. Source: Reactome synaptic transmissionTraceable author statement. Source: Reactome |
| Cellular component | voltage-gated potassium channel complex Inferred from electronic annotation. Source: InterPro |
| Molecular function | voltage-gated potassium channel activity Inferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Alternative products
| This entry describes 4 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q96PR1-1) Also known as: Kv3.2b; This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q96PR1-2) Also known as: Kv3.2d; The sequence of this isoform differs from the canonical sequence as follows: 594-638: GYEKSRSLNN...RSRSPIPSIL → VLYRIYHGLL...GNRLLLLNVP | ||||||
| Isoform 3 (identifier: Q96PR1-3) Also known as: Kv3.2a; The sequence of this isoform differs from the canonical sequence as follows: 594-638: GYEKSRSLNNIAGLAGNALRLSPVTSPYNSPCPLRRSRSPIPSIL → DNCKEVVITGYTQAEARSLT | ||||||
| Isoform 4 (identifier: Q96PR1-4) Also known as: Kv3.2c; The sequence of this isoform differs from the canonical sequence as follows: 539-558: VLSGDDSTGSEPPLSPPERL → DNCKEVVITGYTQAEARSLT 559-638: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 638 | 638 | Potassium voltage-gated channel subfamily C member 2 | PRO_0000310416 | |||||
Regions | |||||||||
| Topological domain | 1 – 229 | 229 | Cytoplasmic Potential | ||||||
| Transmembrane | 230 – 250 | 21 | Helical; Name=Segment S1; Potential | ||||||
| Transmembrane | 284 – 303 | 20 | Helical; Name=Segment S2; Potential | ||||||
| Topological domain | 304 – 313 | 10 | Cytoplasmic Potential | ||||||
| Transmembrane | 314 – 334 | 21 | Helical; Name=Segment S3; Potential | ||||||
| Transmembrane | 346 – 368 | 23 | Helical; Voltage-sensor; Name=Segment S4; Potential | ||||||
| Topological domain | 369 – 381 | 13 | Cytoplasmic Potential | ||||||
| Transmembrane | 382 – 402 | 21 | Helical; Name=Segment S5; Potential | ||||||
| Transmembrane | 453 – 473 | 21 | Helical; Name=Segment S6; Potential | ||||||
| Topological domain | 474 – 638 | 165 | Cytoplasmic Potential | ||||||
| Region | 437 – 442 | 6 | Selectivity filter By similarity | ||||||
| Compositional bias | 56 – 99 | 44 | Gly/Pro-rich (insert) | ||||||
Amino acid modifications | |||||||||
| Glycosylation | 259 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 266 | 1 | N-linked (GlcNAc...) Potential | ||||||
Natural variations | |||||||||
| Alternative sequence | 539 – 558 | 20 | VLSGD…PPERL → DNCKEVVITGYTQAEARSLT in isoform 4. | VSP_029269 | |||||
| Alternative sequence | 559 – 638 | 80 | Missing in isoform 4. | VSP_029270 | |||||
| Alternative sequence | 594 – 638 | 45 | GYEKS…IPSIL → VLYRIYHGLLTAEKGTVEFS HTKDYTGNRLLLLNVP in isoform 2. | VSP_029271 | |||||
| Alternative sequence | 594 – 638 | 45 | GYEKS…IPSIL → DNCKEVVITGYTQAEARSLT in isoform 3. | VSP_029272 | |||||
Experimental info | |||||||||
| Sequence conflict | 305 | 1 | P → S in BAE06076. Ref.4 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Localization of Shaw-related K+ channel genes on mouse and human chromosomes." Haas M., Ward D.C., Lee J., Roses A.D., Clarke V., D'Eustachio P., Lau D., Vega-Saenz de Miera E., Rudy B. Mamm. Genome 4:711-715(1993) [PubMed: 8111118] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3). |
| [2] | Isbrandt D., Pongs O. Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). |
| [3] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Amygdala. |
| [4] | "Preparation of a set of expression-ready clones of mammalian long cDNAs encoding large proteins by the ORF trap cloning method." Nakajima D., Saito K., Yamakawa H., Kikuno R.F., Nakayama M., Ohara R., Okazaki N., Koga H., Nagase T., Ohara O. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain. |
| [5] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [6] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Brain. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AF268896 mRNA. Translation: AAL27272.1. AF268897 mRNA. Translation: AAL27273.1. AY243473 mRNA. Translation: AAO89503.1. AY118169 mRNA. Translation: AAM81577.1. AK094720 mRNA. Translation: BAC04407.1. AB209994 mRNA. Translation: BAE06076.1. Different initiation. CH471054 Genomic DNA. Translation: EAW97287.1. CH471054 Genomic DNA. Translation: EAW97288.1. CH471054 Genomic DNA. Translation: EAW97289.1. CH471054 Genomic DNA. Translation: EAW97291.1. BC093635 mRNA. Translation: AAH93635.1. BC111991 mRNA. Translation: AAI11992.1. |
| IPI | IPI00162733. IPI00221367. IPI00790384. IPI01011210. |
| RefSeq | NP_631874.1. NM_139136.2. NP_631875.1. NM_139137.2. NP_715624.1. NM_153748.1. |
| UniGene | Hs.27214. |
3D structure databases | |
| HSSP | HSSP built from PDB template 2A79 based on UniProtKB P63142. |
| ProteinModelPortal | Q96PR1. |
| SMR | Q96PR1. Positions 7-482. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q96PR1. |
PTM databases | |
| PhosphoSite | Q96PR1. |
Polymorphism databases | |
| DMDM | 74752079. |
Proteomic databases | |
| PRIDE | Q96PR1. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENST00000393288; ENSP00000376966; ENSG00000166006. |
| GeneID | 3747. |
| KEGG | hsa:3747. |
| UCSC | uc001sxe.1. human. uc001sxf.1. human. uc001sxg.1. human. uc009zry.1. human. |
Organism-specific databases | |
| CTD | 3747. |
| GeneCards | GC12M075433. |
| HGNC | HGNC:6234. KCNC2. |
| HPA | CAB022571. HPA019664. |
| MIM | 176256. gene. |
| neXtProt | NX_Q96PR1. |
| PharmGKB | PA35490. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | prNOG10322. |
| GeneTree | ENSGT00580000081499. |
| HOGENOM | HBG445693. |
| HOVERGEN | HBG105862. |
| InParanoid | Q96PR1. |
| OMA | LLDHNRS. |
| OrthoDB | EOG4JQ3X8. |
| PhylomeDB | Q96PR1. |
Enzyme and pathway databases | |
| Reactome | REACT_111217. Metabolism. REACT_13685. Neuronal System. |
Gene expression databases | |
| ArrayExpress | Q96PR1. |
| Bgee | Q96PR1. |
| CleanEx | HS_KCNC2. |
| Genevestigator | Q96PR1. |
Family and domain databases | |
| InterPro | IPR000210. BTB/POZ-like. IPR011333. BTB/POZ_fold. IPR005821. Ion_trans. IPR003091. K_chnl. IPR003968. K_chnl_volt-dep_Kv. IPR003974. K_chnl_volt-dep_Kv3. IPR003131. K_chnl_volt-dep_Kv_tetra. [Graphical view] |
| Gene3D | G3DSA:3.30.710.10. BTB/POZ_fold. 2 hits. |
| KO | K04888. |
| Pfam | PF00520. Ion_trans. 1 hit. PF02214. K_tetra. 1 hit. [Graphical view] |
| PRINTS | PR00169. KCHANNEL. PR01491. KVCHANNEL. PR01498. SHAWCHANNEL. |
| SMART | SM00225. BTB. 1 hit. [Graphical view] |
| SUPFAM | SSF54695. BTB/POZ_fold. 1 hit. |
| ProtoNet | Search... |
Other | |
| NextBio | 14663. |
| SOURCE | Search... |
Entry information
| Entry name | KCNC2_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q96PR1 Secondary accession number(s): Q4LE77 Q96PR0 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 12 Human chromosome 12: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

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