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Protein

Zinc finger protein 317

Gene

ZNF317

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May function as a transcription factor. May play an important role in erythroid maturation and lymphoid proliferation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri222 – 244C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri250 – 272C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri278 – 300C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri306 – 328C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri334 – 356C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri362 – 384C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri390 – 412C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri418 – 440C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri446 – 468C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri474 – 496C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri502 – 524C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri530 – 552C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri558 – 580C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 317
Gene namesi
Name:ZNF317
Synonyms:KIAA1588
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000130803.14.
HGNCiHGNC:13507. ZNF317.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000130803.
PharmGKBiPA37793.

Polymorphism and mutation databases

BioMutaiZNF317.
DMDMi229462794.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475261 – 595Zinc finger protein 317Add BLAST595

Proteomic databases

MaxQBiQ96PQ6.
PaxDbiQ96PQ6.
PeptideAtlasiQ96PQ6.
PRIDEiQ96PQ6.

PTM databases

iPTMnetiQ96PQ6.
PhosphoSitePlusiQ96PQ6.

Expressioni

Tissue specificityi

Isoform 1 and isoform 2 are ubiquitously expressed. Isoform 3 and isoform 4 are expressed only in lymphocytes, spleen and lung.1 Publication

Gene expression databases

BgeeiENSG00000130803.
CleanExiHS_ZNF317.
ExpressionAtlasiQ96PQ6. baseline and differential.
GenevisibleiQ96PQ6. HS.

Organism-specific databases

HPAiHPA042075.
HPA048625.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi121719. 18 interactors.
IntActiQ96PQ6. 16 interactors.
STRINGi9606.ENSP00000247956.

Structurei

3D structure databases

ProteinModelPortaliQ96PQ6.
SMRiQ96PQ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini57 – 128KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri222 – 244C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri250 – 272C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri278 – 300C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri306 – 328C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri334 – 356C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri362 – 384C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri390 – 412C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri418 – 440C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri446 – 468C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri474 – 496C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri502 – 524C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri530 – 552C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri558 – 580C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129830.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ96PQ6.
KOiK09228.
OMAiAFRNQST.
OrthoDBiEOG091G02KC.
PhylomeDBiQ96PQ6.
TreeFamiTF338497.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.40.10. 2 hits.
InterProiView protein in InterPro
IPR001909. KRAB.
IPR013087. Znf_C2H2_type.
IPR013083. Znf_RING/FYVE/PHD.
PfamiView protein in Pfam
PF01352. KRAB. 1 hit.
SMARTiView protein in SMART
SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF57667. SSF57667. 8 hits.
PROSITEiView protein in PROSITE
PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 2 (identifier: Q96PQ6-1) [UniParc]FASTAAdd to basket
Also known as: ZNF317-2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAALSPTFAT STQDSTCLQD SEFPVSSKDH SCPQNLDLFV CSGLEPHTPS
60 70 80 90 100
VGSQESVTFQ DVAVDFTEKE WPLLDSSQRK LYKDVMLENY SNLTSLGYQV
110 120 130 140 150
GKPSLISHLE QEEEPRTEER GAHQGACADW ETPSKTKWSL LMEDIFGKET
160 170 180 190 200
PSGVTMERAG LGEKSTEYAH LFEVFGMDPH LTQPMGRHAG KRPYHRRDYG
210 220 230 240 250
VAFKGRPHLT QHMSMYDGRK MHECHQCQKA FTTSASLTRH RRIHTGEKPY
260 270 280 290 300
ECSDCGKAFN DPSALRSHAR THLKEKPFDC SQCGNAFRTL SALKIHMRVH
310 320 330 340 350
TGERPYKCDQ CGKAYGRSCH LIAHKRTHTG ERPYECHDCG KAFQHPSHLK
360 370 380 390 400
EHVRNHTGEK PYACTQCGKA FRWKSNFNLH KKNHMVEKTY ECKECGKSFG
410 420 430 440 450
DLVSRRKHMR IHIVKKPVEC RQCGKTFRNQ SILKTHMNSH TGEKPYGCDL
460 470 480 490 500
CGKAFSASSN LTAHRKIHTQ ERRYECAACG KVFGDYLSRR RHMSVHLVKK
510 520 530 540 550
RVECRQCGKA FRNQSTLKTH MRSHTGEKPY ECDHCGKAFS IGSNLNVHRR
560 570 580 590
IHTGEKPYEC LVCGKAFSDH SSLRSHVKTH RGEKLFVSSV WKRLQ
Length:595
Mass (Da):67,959
Last modified:May 5, 2009 - v2
Checksum:i9AF99586A1882A9D
GO
Isoform 1 (identifier: Q96PQ6-2) [UniParc]FASTAAdd to basket
Also known as: ZNF317-1

The sequence of this isoform differs from the canonical sequence as follows:
     97-128: Missing.

Show »
Length:563
Mass (Da):64,469
Checksum:i33D88D90C952AC9B
GO
Isoform 3 (identifier: Q96PQ6-3) [UniParc]FASTAAdd to basket
Also known as: ZNF317-3

The sequence of this isoform differs from the canonical sequence as follows:
     1-85: Missing.
     97-128: Missing.

Show »
Length:478
Mass (Da):55,131
Checksum:i3BD1D9ED463B7522
GO
Isoform 4 (identifier: Q96PQ6-4) [UniParc]FASTAAdd to basket
Also known as: ZNF317-4

The sequence of this isoform differs from the canonical sequence as follows:
     1-85: Missing.

Show »
Length:510
Mass (Da):58,621
Checksum:i3E2AEC20E5B2174B
GO

Sequence cautioni

The sequence BAB13414 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti409M → I in AAL29182 (PubMed:11688974).Curated1
Sequence conflicti409M → I in AAL29188 (PubMed:11688974).Curated1
Sequence conflicti409M → I in AAL29190 (PubMed:11688974).Curated1
Sequence conflicti409M → I in AAL29191 (PubMed:11688974).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01998019Q → H. Corresponds to variant dbSNP:rs3752199Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0069151 – 85Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST85
Alternative sequenceiVSP_00691697 – 128Missing in isoform 1 and isoform 3. 3 PublicationsAdd BLAST32

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF275255 mRNA. Translation: AAL29188.1.
AF148135 mRNA. Translation: AAL29182.1.
AF307096 mRNA. Translation: AAL29190.1.
AF307097 mRNA. Translation: AAL29191.1.
AB046808 mRNA. Translation: BAB13414.1. Different initiation.
CH471106 Genomic DNA. Translation: EAW84011.1.
BC078154 mRNA. Translation: AAH78154.1.
CCDSiCCDS12210.1. [Q96PQ6-1]
CCDS54213.1. [Q96PQ6-2]
PIRiJC7779.
RefSeqiNP_001177720.1. NM_001190791.1. [Q96PQ6-2]
NP_065984.3. NM_020933.4. [Q96PQ6-1]
UniGeneiHs.465829.

Genome annotation databases

EnsembliENST00000247956; ENSP00000247956; ENSG00000130803. [Q96PQ6-1]
ENST00000360385; ENSP00000353554; ENSG00000130803. [Q96PQ6-2]
GeneIDi57693.
KEGGihsa:57693.
UCSCiuc002mku.4. human. [Q96PQ6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN317_HUMAN
AccessioniPrimary (citable) accession number: Q96PQ6
Secondary accession number(s): Q6DCA9
, Q96PM0, Q96PM1, Q96PT2, Q9HCI4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: May 5, 2009
Last modified: September 27, 2017
This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families