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Protein

Zinc finger protein 317

Gene

ZNF317

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May function as a transcription factor. May play an important role in erythroid maturation and lymphoid proliferation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri222 – 24423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri250 – 27223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri278 – 30023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri306 – 32823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri334 – 35623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri362 – 38423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri390 – 41223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri418 – 44023C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri446 – 46823C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri474 – 49623C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri502 – 52423C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri530 – 55223C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri558 – 58023C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 317
Gene namesi
Name:ZNF317
Synonyms:KIAA1588
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:13507. ZNF317.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37793.

Polymorphism and mutation databases

BioMutaiZNF317.
DMDMi229462794.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 595595Zinc finger protein 317PRO_0000047526Add
BLAST

Proteomic databases

MaxQBiQ96PQ6.
PaxDbiQ96PQ6.
PeptideAtlasiQ96PQ6.
PRIDEiQ96PQ6.

PTM databases

iPTMnetiQ96PQ6.
PhosphoSiteiQ96PQ6.

Expressioni

Tissue specificityi

Isoform 1 and isoform 2 are ubiquitously expressed. Isoform 3 and isoform 4 are expressed only in lymphocytes, spleen and lung.1 Publication

Gene expression databases

BgeeiENSG00000130803.
CleanExiHS_ZNF317.
ExpressionAtlasiQ96PQ6. baseline and differential.
GenevisibleiQ96PQ6. HS.

Organism-specific databases

HPAiHPA042075.
HPA048625.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
AENQ8WTP83EBI-1210473,EBI-8637627
C11orf57Q6ZUT13EBI-1210473,EBI-3920396
KRT40Q6A1623EBI-10292528,EBI-10171697
KRTAP10-9P604113EBI-10292528,EBI-10172052
RBMY1A1P0DJD34EBI-1210473,EBI-8638511

Protein-protein interaction databases

BioGridi121719. 17 interactions.
IntActiQ96PQ6. 6 interactions.
STRINGi9606.ENSP00000247956.

Structurei

3D structure databases

ProteinModelPortaliQ96PQ6.
SMRiQ96PQ6. Positions 57-98, 157-580.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini57 – 12872KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 13 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri222 – 24423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri250 – 27223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri278 – 30023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri306 – 32823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri334 – 35623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri362 – 38423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri390 – 41223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri418 – 44023C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri446 – 46823C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri474 – 49623C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri502 – 52423C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri530 – 55223C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri558 – 58023C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129830.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ96PQ6.
KOiK09228.
OMAiRSCHLIA.
OrthoDBiEOG091G02KC.
PhylomeDBiQ96PQ6.
TreeFamiTF338497.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 13 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 5 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 2 (identifier: Q96PQ6-1) [UniParc]FASTAAdd to basket
Also known as: ZNF317-2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAALSPTFAT STQDSTCLQD SEFPVSSKDH SCPQNLDLFV CSGLEPHTPS
60 70 80 90 100
VGSQESVTFQ DVAVDFTEKE WPLLDSSQRK LYKDVMLENY SNLTSLGYQV
110 120 130 140 150
GKPSLISHLE QEEEPRTEER GAHQGACADW ETPSKTKWSL LMEDIFGKET
160 170 180 190 200
PSGVTMERAG LGEKSTEYAH LFEVFGMDPH LTQPMGRHAG KRPYHRRDYG
210 220 230 240 250
VAFKGRPHLT QHMSMYDGRK MHECHQCQKA FTTSASLTRH RRIHTGEKPY
260 270 280 290 300
ECSDCGKAFN DPSALRSHAR THLKEKPFDC SQCGNAFRTL SALKIHMRVH
310 320 330 340 350
TGERPYKCDQ CGKAYGRSCH LIAHKRTHTG ERPYECHDCG KAFQHPSHLK
360 370 380 390 400
EHVRNHTGEK PYACTQCGKA FRWKSNFNLH KKNHMVEKTY ECKECGKSFG
410 420 430 440 450
DLVSRRKHMR IHIVKKPVEC RQCGKTFRNQ SILKTHMNSH TGEKPYGCDL
460 470 480 490 500
CGKAFSASSN LTAHRKIHTQ ERRYECAACG KVFGDYLSRR RHMSVHLVKK
510 520 530 540 550
RVECRQCGKA FRNQSTLKTH MRSHTGEKPY ECDHCGKAFS IGSNLNVHRR
560 570 580 590
IHTGEKPYEC LVCGKAFSDH SSLRSHVKTH RGEKLFVSSV WKRLQ
Length:595
Mass (Da):67,959
Last modified:May 5, 2009 - v2
Checksum:i9AF99586A1882A9D
GO
Isoform 1 (identifier: Q96PQ6-2) [UniParc]FASTAAdd to basket
Also known as: ZNF317-1

The sequence of this isoform differs from the canonical sequence as follows:
     97-128: Missing.

Show »
Length:563
Mass (Da):64,469
Checksum:i33D88D90C952AC9B
GO
Isoform 3 (identifier: Q96PQ6-3) [UniParc]FASTAAdd to basket
Also known as: ZNF317-3

The sequence of this isoform differs from the canonical sequence as follows:
     1-85: Missing.
     97-128: Missing.

Show »
Length:478
Mass (Da):55,131
Checksum:i3BD1D9ED463B7522
GO
Isoform 4 (identifier: Q96PQ6-4) [UniParc]FASTAAdd to basket
Also known as: ZNF317-4

The sequence of this isoform differs from the canonical sequence as follows:
     1-85: Missing.

Show »
Length:510
Mass (Da):58,621
Checksum:i3E2AEC20E5B2174B
GO

Sequence cautioni

The sequence BAB13414 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti409 – 4091M → I in AAL29182 (PubMed:11688974).Curated
Sequence conflicti409 – 4091M → I in AAL29188 (PubMed:11688974).Curated
Sequence conflicti409 – 4091M → I in AAL29190 (PubMed:11688974).Curated
Sequence conflicti409 – 4091M → I in AAL29191 (PubMed:11688974).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti19 – 191Q → H.
Corresponds to variant rs3752199 [ dbSNP | Ensembl ].
VAR_019980

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8585Missing in isoform 3 and isoform 4. 1 PublicationVSP_006915Add
BLAST
Alternative sequencei97 – 12832Missing in isoform 1 and isoform 3. 3 PublicationsVSP_006916Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF275255 mRNA. Translation: AAL29188.1.
AF148135 mRNA. Translation: AAL29182.1.
AF307096 mRNA. Translation: AAL29190.1.
AF307097 mRNA. Translation: AAL29191.1.
AB046808 mRNA. Translation: BAB13414.1. Different initiation.
CH471106 Genomic DNA. Translation: EAW84011.1.
BC078154 mRNA. Translation: AAH78154.1.
CCDSiCCDS12210.1. [Q96PQ6-1]
CCDS54213.1. [Q96PQ6-2]
PIRiJC7779.
RefSeqiNP_001177720.1. NM_001190791.1. [Q96PQ6-2]
NP_065984.3. NM_020933.4. [Q96PQ6-1]
UniGeneiHs.465829.

Genome annotation databases

EnsembliENST00000247956; ENSP00000247956; ENSG00000130803. [Q96PQ6-1]
ENST00000360385; ENSP00000353554; ENSG00000130803. [Q96PQ6-2]
GeneIDi57693.
KEGGihsa:57693.
UCSCiuc002mku.4. human. [Q96PQ6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF275255 mRNA. Translation: AAL29188.1.
AF148135 mRNA. Translation: AAL29182.1.
AF307096 mRNA. Translation: AAL29190.1.
AF307097 mRNA. Translation: AAL29191.1.
AB046808 mRNA. Translation: BAB13414.1. Different initiation.
CH471106 Genomic DNA. Translation: EAW84011.1.
BC078154 mRNA. Translation: AAH78154.1.
CCDSiCCDS12210.1. [Q96PQ6-1]
CCDS54213.1. [Q96PQ6-2]
PIRiJC7779.
RefSeqiNP_001177720.1. NM_001190791.1. [Q96PQ6-2]
NP_065984.3. NM_020933.4. [Q96PQ6-1]
UniGeneiHs.465829.

3D structure databases

ProteinModelPortaliQ96PQ6.
SMRiQ96PQ6. Positions 57-98, 157-580.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121719. 17 interactions.
IntActiQ96PQ6. 6 interactions.
STRINGi9606.ENSP00000247956.

PTM databases

iPTMnetiQ96PQ6.
PhosphoSiteiQ96PQ6.

Polymorphism and mutation databases

BioMutaiZNF317.
DMDMi229462794.

Proteomic databases

MaxQBiQ96PQ6.
PaxDbiQ96PQ6.
PeptideAtlasiQ96PQ6.
PRIDEiQ96PQ6.

Protocols and materials databases

DNASUi57693.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000247956; ENSP00000247956; ENSG00000130803. [Q96PQ6-1]
ENST00000360385; ENSP00000353554; ENSG00000130803. [Q96PQ6-2]
GeneIDi57693.
KEGGihsa:57693.
UCSCiuc002mku.4. human. [Q96PQ6-1]

Organism-specific databases

CTDi57693.
GeneCardsiZNF317.
HGNCiHGNC:13507. ZNF317.
HPAiHPA042075.
HPA048625.
MIMi613864. gene.
neXtProtiNX_Q96PQ6.
PharmGKBiPA37793.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129830.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ96PQ6.
KOiK09228.
OMAiRSCHLIA.
OrthoDBiEOG091G02KC.
PhylomeDBiQ96PQ6.
TreeFamiTF338497.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF317. human.
GenomeRNAii57693.
PROiQ96PQ6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000130803.
CleanExiHS_ZNF317.
ExpressionAtlasiQ96PQ6. baseline and differential.
GenevisibleiQ96PQ6. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 13 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 5 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN317_HUMAN
AccessioniPrimary (citable) accession number: Q96PQ6
Secondary accession number(s): Q6DCA9
, Q96PM0, Q96PM1, Q96PT2, Q9HCI4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: May 5, 2009
Last modified: September 7, 2016
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.