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Protein

Sialic acid-binding Ig-like lectin 12

Gene

SIGLEC12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Lectin

Enzyme and pathway databases

BioCyciZFISH:G66-30735-MONOMER.
ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Names & Taxonomyi

Protein namesi
Recommended name:
Sialic acid-binding Ig-like lectin 12
Short name:
Siglec-12
Alternative name(s):
Sialic acid-binding Ig-like lectin-like 1
Short name:
Siglec-L1
Gene namesi
Name:SIGLEC12
Synonyms:SIGLECL1, SLG
ORF Names:UNQ9215/PRO34042
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:15482. SIGLEC12.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 481ExtracellularSequence analysisAdd BLAST463
Transmembranei482 – 502HelicalSequence analysisAdd BLAST21
Topological domaini503 – 595CytoplasmicSequence analysisAdd BLAST93

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi89858.
OpenTargetsiENSG00000254521.
PharmGKBiPA37966.

Polymorphism and mutation databases

BioMutaiSIGLEC12.
DMDMi25009264.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000001495319 – 595Sialic acid-binding Ig-like lectin 12Add BLAST577

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi44 ↔ 104PROSITE-ProRule annotation
Glycosylationi140N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi166 ↔ 299PROSITE-ProRule annotation
Disulfide bondi171 ↔ 231PROSITE-ProRule annotation
Glycosylationi179N-linked (GlcNAc...)Sequence analysis1
Glycosylationi230N-linked (GlcNAc...)Sequence analysis1
Glycosylationi290N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi293 ↔ 342PROSITE-ProRule annotation
Glycosylationi360N-linked (GlcNAc...)Sequence analysis1
Glycosylationi367N-linked (GlcNAc...)Sequence analysis1
Glycosylationi385N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi401 ↔ 446PROSITE-ProRule annotation
Modified residuei565PhosphotyrosineBy similarity1
Modified residuei588PhosphotyrosineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ96PQ1.
PeptideAtlasiQ96PQ1.
PRIDEiQ96PQ1.

PTM databases

iPTMnetiQ96PQ1.
PhosphoSitePlusiQ96PQ1.

Expressioni

Tissue specificityi

Isoform Short is highly expressed in spleen, small intestine and adrenal gland; it is lower expressed in thyroid, placenta, brain, stomach, bone marrow, spinal chord and breast. Isoform Long is highly expressed in spleen, small intestine and bone marrow; it is lower expressed in thyroid, placenta, thymus, trachea, stomach, lung, adrenal gland, fetal brain and testis.

Gene expression databases

BgeeiENSG00000254521.
CleanExiHS_SIGLEC12.
ExpressionAtlasiQ96PQ1. baseline and differential.

Interactioni

Protein-protein interaction databases

BioGridi124623. 8 interactors.
STRINGi9606.ENSP00000291707.

Structurei

3D structure databases

ProteinModelPortaliQ96PQ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 142Ig-like V-type 1Add BLAST124
Domaini143 – 269Ig-like V-type 2Add BLAST127
Domaini275 – 358Ig-like C2-type 1Add BLAST84
Domaini365 – 462Ig-like C2-type 2Add BLAST98

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi563 – 568ITIM motif6
Motifi586 – 591SLAM-like motif6

Domaini

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJT6. Eukaryota.
ENOG410YKZU. LUCA.
GeneTreeiENSGT00760000119139.
HOGENOMiHOG000236324.
HOVERGENiHBG036161.
InParanoidiQ96PQ1.
KOiK10079.
OMAiTGIEYSE.
OrthoDBiEOG091G0445.
PhylomeDBiQ96PQ1.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 4 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Long (identifier: Q96PQ1-1) [UniParc]FASTAAdd to basket
Also known as: SLG-L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLLLLLLLPP LLCGRVGAKE QKDYLLTMQK SVTVQEGLCV SVLCSFSYPQ
60 70 80 90 100
NGWTASDPVH GYWFRAGDHV SRNIPVATNN PARAVQEETR DRFHLLGDPQ
110 120 130 140 150
NKDCTLSIRD TRESDAGTYV FCVERGNMKW NYKYDQLSVN VTASQDLLSR
160 170 180 190 200
YRLEVPESVT VQEGLCVSVP CSVLYPHYNW TASSPVYGSW FKEGADIPWD
210 220 230 240 250
IPVATNTPSG KVQEDTHGRF LLLGDPQTNN CSLSIRDARK GDSGKYYFQV
260 270 280 290 300
ERGSRKWNYI YDKLSVHVTA LTHMPTFSIP GTLESGHPRN LTCSVPWACE
310 320 330 340 350
QGTPPTITWM GASVSSLDPT ITRSSMLSLI PQPQDHGTSL TCQVTLPGAG
360 370 380 390 400
VTMTRAVRLN ISYPPQNLTM TVFQGDGTAS TTLRNGSALS VLEGQSLHLV
410 420 430 440 450
CAVDSNPPAR LSWTWGSLTL SPSQSSNLGV LELPRVHVKD EGEFTCRAQN
460 470 480 490 500
PLGSQHISLS LSLQNEYTGK MRPISGVTLG AFGGAGATAL VFLYFCIIFV
510 520 530 540 550
VVRSCRKKSA RPAVGVGDTG MEDANAVRGS ASQGPLIESP ADDSPPHHAP
560 570 580 590
PALATPSPEE GEIQYASLSF HKARPQYPQE QEAIGYEYSE INIPK
Length:595
Mass (Da):64,984
Last modified:December 1, 2001 - v1
Checksum:iD05662176274C5C3
GO
Isoform Short (identifier: Q96PQ1-2) [UniParc]FASTAAdd to basket
Also known as: SLG-S

The sequence of this isoform differs from the canonical sequence as follows:
     4-141: LLLLLPPLLC...YKYDQLSVNV → PLLWANEERDSGGWADPRFS

Show »
Length:477
Mass (Da):51,663
Checksum:iD50A55248BD7A9EB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti528R → W in AAQ88507 (PubMed:12975309).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04993181P → H.Corresponds to variant rs2034891dbSNPEnsembl.1
Natural variantiVAR_01425981P → T.Corresponds to variant rs2034891dbSNPEnsembl.1
Natural variantiVAR_04993282A → V.Corresponds to variant rs3810110dbSNPEnsembl.1
Natural variantiVAR_024501217H → Q.Corresponds to variant rs6509544dbSNPEnsembl.1
Natural variantiVAR_049933218G → R.Corresponds to variant rs6509544dbSNPEnsembl.1
Natural variantiVAR_049934398H → Y.Corresponds to variant rs11668530dbSNPEnsembl.1
Natural variantiVAR_020088478T → M.Corresponds to variant rs3829658dbSNPEnsembl.1
Natural variantiVAR_020089494Y → S.Corresponds to variant rs3752135dbSNPEnsembl.1
Natural variantiVAR_061327546P → Q.Corresponds to variant rs57043266dbSNPEnsembl.1
Natural variantiVAR_049935586Y → C.Corresponds to variant rs7245807dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0025664 – 141LLLLL…LSVNV → PLLWANEERDSGGWADPRFS in isoform Short. CuratedAdd BLAST138

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF277806 Genomic DNA. Translation: AAK51233.1.
AF277806 Genomic DNA. Translation: AAK51234.1.
AF282256 mRNA. Translation: AAK71521.1.
AY358140 mRNA. Translation: AAQ88507.1.
BC035809 mRNA. Translation: AAH35809.2.
CCDSiCCDS12833.1. [Q96PQ1-1]
CCDS59416.1. [Q96PQ1-2]
RefSeqiNP_201586.1. NM_033329.2. [Q96PQ1-2]
NP_443729.1. NM_053003.3. [Q96PQ1-1]
XP_011525743.1. XM_011527441.2. [Q96PQ1-2]
UniGeneiHs.249741.

Genome annotation databases

EnsembliENST00000291707; ENSP00000291707; ENSG00000254521. [Q96PQ1-1]
ENST00000598614; ENSP00000472873; ENSG00000254521. [Q96PQ1-2]
GeneIDi89858.
KEGGihsa:89858.
UCSCiuc002pww.3. human. [Q96PQ1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Siglec-L1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF277806 Genomic DNA. Translation: AAK51233.1.
AF277806 Genomic DNA. Translation: AAK51234.1.
AF282256 mRNA. Translation: AAK71521.1.
AY358140 mRNA. Translation: AAQ88507.1.
BC035809 mRNA. Translation: AAH35809.2.
CCDSiCCDS12833.1. [Q96PQ1-1]
CCDS59416.1. [Q96PQ1-2]
RefSeqiNP_201586.1. NM_033329.2. [Q96PQ1-2]
NP_443729.1. NM_053003.3. [Q96PQ1-1]
XP_011525743.1. XM_011527441.2. [Q96PQ1-2]
UniGeneiHs.249741.

3D structure databases

ProteinModelPortaliQ96PQ1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124623. 8 interactors.
STRINGi9606.ENSP00000291707.

PTM databases

iPTMnetiQ96PQ1.
PhosphoSitePlusiQ96PQ1.

Polymorphism and mutation databases

BioMutaiSIGLEC12.
DMDMi25009264.

Proteomic databases

PaxDbiQ96PQ1.
PeptideAtlasiQ96PQ1.
PRIDEiQ96PQ1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000291707; ENSP00000291707; ENSG00000254521. [Q96PQ1-1]
ENST00000598614; ENSP00000472873; ENSG00000254521. [Q96PQ1-2]
GeneIDi89858.
KEGGihsa:89858.
UCSCiuc002pww.3. human. [Q96PQ1-1]

Organism-specific databases

CTDi89858.
DisGeNETi89858.
GeneCardsiSIGLEC12.
HGNCiHGNC:15482. SIGLEC12.
MIMi606094. gene.
neXtProtiNX_Q96PQ1.
OpenTargetsiENSG00000254521.
PharmGKBiPA37966.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJT6. Eukaryota.
ENOG410YKZU. LUCA.
GeneTreeiENSGT00760000119139.
HOGENOMiHOG000236324.
HOVERGENiHBG036161.
InParanoidiQ96PQ1.
KOiK10079.
OMAiTGIEYSE.
OrthoDBiEOG091G0445.
PhylomeDBiQ96PQ1.

Enzyme and pathway databases

BioCyciZFISH:G66-30735-MONOMER.
ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Miscellaneous databases

GeneWikiiSialic_acid-binding_Ig-like_lectin_12.
GenomeRNAii89858.
PROiQ96PQ1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000254521.
CleanExiHS_SIGLEC12.
ExpressionAtlasiQ96PQ1. baseline and differential.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 4 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSIG12_HUMAN
AccessioniPrimary (citable) accession number: Q96PQ1
Secondary accession number(s): Q8IYH7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 149 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.