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Protein

VPS10 domain-containing receptor SorCS2

Gene

SORCS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • neuropeptide receptor activity Source: UniProtKB

GO - Biological processi

  • neuropeptide signaling pathway Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-31078-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
VPS10 domain-containing receptor SorCS2
Gene namesi
Name:SORCS2
Synonyms:KIAA1329
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:16698. SORCS2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini51 – 1078LumenalSequence analysisAdd BLAST1028
Transmembranei1079 – 1099HelicalSequence analysisAdd BLAST21
Topological domaini1100 – 1159CytoplasmicSequence analysisAdd BLAST60

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi57537.
OpenTargetsiENSG00000184985.
PharmGKBiPA134902026.

Polymorphism and mutation databases

BioMutaiSORCS2.
DMDMi296453015.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 50Sequence analysisAdd BLAST50
ChainiPRO_000003317251 – 1159VPS10 domain-containing receptor SorCS2Add BLAST1109

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi158N-linked (GlcNAc...)Sequence analysis1
Glycosylationi328N-linked (GlcNAc...)Sequence analysis1
Glycosylationi362N-linked (GlcNAc...)Sequence analysis1
Glycosylationi600N-linked (GlcNAc...)Sequence analysis1
Glycosylationi830N-linked (GlcNAc...)Sequence analysis1
Glycosylationi891N-linked (GlcNAc...)Sequence analysis1
Glycosylationi902N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ96PQ0.
PeptideAtlasiQ96PQ0.
PRIDEiQ96PQ0.

PTM databases

iPTMnetiQ96PQ0.
PhosphoSitePlusiQ96PQ0.
SwissPalmiQ96PQ0.

Expressioni

Tissue specificityi

Highly expressed in brain and kidney. Detected at low levels in heart, liver, small intestine, skeletal muscle and thymus.

Gene expression databases

BgeeiENSG00000184985.
CleanExiHS_SORCS2.
ExpressionAtlasiQ96PQ0. baseline and differential.
GenevisibleiQ96PQ0. HS.

Interactioni

Protein-protein interaction databases

IntActiQ96PQ0. 6 interactors.
STRINGi9606.ENSP00000422185.

Structurei

Secondary structure

11159
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi782 – 789Combined sources8
Beta strandi800 – 808Combined sources9
Beta strandi815 – 819Combined sources5
Beta strandi821 – 823Combined sources3
Beta strandi825 – 830Combined sources6
Helixi831 – 834Combined sources4
Beta strandi838 – 840Combined sources3
Beta strandi848 – 855Combined sources8
Beta strandi860 – 867Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WGONMR-A760-869[»]
ProteinModelPortaliQ96PQ0.
SMRiQ96PQ0.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96PQ0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati182 – 193BNR 1Add BLAST12
Repeati232 – 243BNR 2Add BLAST12
Repeati273 – 284BNR 3Add BLAST12
Repeati468 – 479BNR 4Add BLAST12
Repeati545 – 556BNR 5Add BLAST12
Repeati587 – 598BNR 6Add BLAST12
Domaini786 – 876PKDPROSITE-ProRule annotationAdd BLAST91

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi13 – 104Pro-richAdd BLAST92

Sequence similaritiesi

Contains 6 BNR repeats.Curated
Contains 1 PKD domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410ISX9. Eukaryota.
ENOG410XNN6. LUCA.
GeneTreeiENSGT00510000046443.
HOGENOMiHOG000236260.
HOVERGENiHBG059252.
InParanoidiQ96PQ0.
OMAiNVRSTKQ.
OrthoDBiEOG091G00JR.
PhylomeDBiQ96PQ0.
TreeFamiTF324918.

Family and domain databases

Gene3Di2.60.40.670. 1 hit.
InterProiIPR022409. PKD/Chitinase_dom.
IPR000601. PKD_dom.
IPR031777. Sortilin_C.
IPR031778. Sortilin_N.
IPR006581. VPS10.
[Graphical view]
PfamiPF00801. PKD. 1 hit.
PF15902. Sortilin-Vps10. 1 hit.
PF15901. Sortilin_C. 1 hit.
[Graphical view]
SMARTiSM00089. PKD. 1 hit.
SM00602. VPS10. 1 hit.
[Graphical view]
SUPFAMiSSF49299. SSF49299. 1 hit.
PROSITEiPS50093. PKD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96PQ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHRGPSRAS KGPGPTARAP SPGAPPPPRS PRSRPLLLLL LLLGACGAAG
60 70 80 90 100
RSPEPGRLGP HAQLTRVPRS PPAGRAEPGG GEDRQARGTE PGAPGPSPGP
110 120 130 140 150
APGPGEDGAP AAGYRRWERA APLAGVASRA QVSLISTSFV LKGDATHNQA
160 170 180 190 200
MVHWTGENSS VILILTKYYH ADMGKVLESS LWRSSDFGTS YTKLTLQPGV
210 220 230 240 250
TTVIDNFYIC PTNKRKVILV SSSLSDRDQS LFLSADEGAT FQKQPIPFFV
260 270 280 290 300
ETLIFHPKEE DKVLAYTKES KLYVSSDLGK KWTLLQERVT KDHVFWSVSG
310 320 330 340 350
VDADPDLVHV EAQDLGGDFR YVTCAIHNCS EKMLTAPFAG PIDHGSLTVQ
360 370 380 390 400
DDYIFFKATS ANQTKYYVSY RRNEFVLMKL PKYALPKDLQ IISTDESQVF
410 420 430 440 450
VAVQEWYQMD TYNLYQSDPR GVRYALVLQD VRSSRQAEES VLIDILEVRG
460 470 480 490 500
VKGVFLANQK IDGKVMTLIT YNKGRDWDYL RPPSMDMNGK PTNCKPPDCH
510 520 530 540 550
LHLHLRWADN PYVSGTVHTK DTAPGLIMGA GNLGSQLVEY KEEMYITSDC
560 570 580 590 600
GHTWRQVFEE EHHILYLDHG GVIVAIKDTS IPLKILKFSV DEGLTWSTHN
610 620 630 640 650
FTSTSVFVDG LLSEPGDETL VMTVFGHISF RSDWELVKVD FRPSFSRQCG
660 670 680 690 700
EEDYSSWELS NLQGDRCIMG QQRSFRKRKS TSWCIKGRSF TSALTSRVCE
710 720 730 740 750
CRDSDFLCDY GFERSSSSES STNKCSANFW FNPLSPPDDC ALGQTYTSSL
760 770 780 790 800
GYRKVVSNVC EGGVDMQQSQ VQLQCPLTPP RGLQVSIQGE AVAVRPGEDV
810 820 830 840 850
LFVVRQEQGD VLTTKYQVDL GDGFKAMYVN LTLTGEPIRH RYESPGIYRV
860 870 880 890 900
SVRAENTAGH DEAVLFVQVN SPLQALYLEV VPVIGLNQEV NLTAVLLPLN
910 920 930 940 950
PNLTVFYWWI GHSLQPLLSL DNSVTTRFSD TGDVRVTVQA ACGNSVLQDS
960 970 980 990 1000
RVLRVLDQFQ VMPLQFSKEL DAYNPNTPEW REDVGLVVTR LLSKETSVPQ
1010 1020 1030 1040 1050
ELLVTVVKPG LPTLADLYVL LPPPRPTRKR SLSSDKRLAA IQQVLNAQKI
1060 1070 1080 1090 1100
SFLLRGGVRV LVALRDTGTG AEQLGGGGGY WAVVVLFVIG LFAAGAFILY
1110 1120 1130 1140 1150
KFKRKRPGRT VYAQMHNEKE QEMTSPVSHS EDVQGAVQGN HSGVVLSINS

REMHSYLVS
Length:1,159
Mass (Da):128,152
Last modified:May 18, 2010 - v3
Checksum:i61DEE8EF428B8B40
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti716S → P in BAA92567 (PubMed:10718198).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_060109345G → R.Corresponds to variant rs34058821dbSNPEnsembl.1
Natural variantiVAR_060110695T → M.Corresponds to variant rs16840892dbSNPEnsembl.1
Natural variantiVAR_060111745T → I.Corresponds to variant rs16840899dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004169 Genomic DNA. No translation available.
AC080003 Genomic DNA. No translation available.
AC097382 Genomic DNA. No translation available.
AC112710 Genomic DNA. No translation available.
AC116316 Genomic DNA. No translation available.
AF286190 mRNA. Translation: AAL04014.1.
AB037750 mRNA. Translation: BAA92567.1.
CCDSiCCDS47008.1.
RefSeqiNP_065828.2. NM_020777.2.
UniGeneiHs.479099.

Genome annotation databases

EnsembliENST00000507866; ENSP00000422185; ENSG00000184985.
GeneIDi57537.
KEGGihsa:57537.
UCSCiuc003gkb.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004169 Genomic DNA. No translation available.
AC080003 Genomic DNA. No translation available.
AC097382 Genomic DNA. No translation available.
AC112710 Genomic DNA. No translation available.
AC116316 Genomic DNA. No translation available.
AF286190 mRNA. Translation: AAL04014.1.
AB037750 mRNA. Translation: BAA92567.1.
CCDSiCCDS47008.1.
RefSeqiNP_065828.2. NM_020777.2.
UniGeneiHs.479099.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WGONMR-A760-869[»]
ProteinModelPortaliQ96PQ0.
SMRiQ96PQ0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ96PQ0. 6 interactors.
STRINGi9606.ENSP00000422185.

PTM databases

iPTMnetiQ96PQ0.
PhosphoSitePlusiQ96PQ0.
SwissPalmiQ96PQ0.

Polymorphism and mutation databases

BioMutaiSORCS2.
DMDMi296453015.

Proteomic databases

PaxDbiQ96PQ0.
PeptideAtlasiQ96PQ0.
PRIDEiQ96PQ0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000507866; ENSP00000422185; ENSG00000184985.
GeneIDi57537.
KEGGihsa:57537.
UCSCiuc003gkb.5. human.

Organism-specific databases

CTDi57537.
DisGeNETi57537.
GeneCardsiSORCS2.
H-InvDBHIX0004076.
HGNCiHGNC:16698. SORCS2.
MIMi606284. gene.
neXtProtiNX_Q96PQ0.
OpenTargetsiENSG00000184985.
PharmGKBiPA134902026.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ISX9. Eukaryota.
ENOG410XNN6. LUCA.
GeneTreeiENSGT00510000046443.
HOGENOMiHOG000236260.
HOVERGENiHBG059252.
InParanoidiQ96PQ0.
OMAiNVRSTKQ.
OrthoDBiEOG091G00JR.
PhylomeDBiQ96PQ0.
TreeFamiTF324918.

Enzyme and pathway databases

BioCyciZFISH:G66-31078-MONOMER.

Miscellaneous databases

ChiTaRSiSORCS2. human.
EvolutionaryTraceiQ96PQ0.
GenomeRNAii57537.
PROiQ96PQ0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000184985.
CleanExiHS_SORCS2.
ExpressionAtlasiQ96PQ0. baseline and differential.
GenevisibleiQ96PQ0. HS.

Family and domain databases

Gene3Di2.60.40.670. 1 hit.
InterProiIPR022409. PKD/Chitinase_dom.
IPR000601. PKD_dom.
IPR031777. Sortilin_C.
IPR031778. Sortilin_N.
IPR006581. VPS10.
[Graphical view]
PfamiPF00801. PKD. 1 hit.
PF15902. Sortilin-Vps10. 1 hit.
PF15901. Sortilin_C. 1 hit.
[Graphical view]
SMARTiSM00089. PKD. 1 hit.
SM00602. VPS10. 1 hit.
[Graphical view]
SUPFAMiSSF49299. SSF49299. 1 hit.
PROSITEiPS50093. PKD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSORC2_HUMAN
AccessioniPrimary (citable) accession number: Q96PQ0
Secondary accession number(s): Q9P2L7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 13, 2002
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 123 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The N-terminus of the protein was constructed in analogy to that of the mouse ortholog using the sequence of chromosome 4.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.