Reviewed, UniProtKB/Swiss-Prot Q96PQ0 (SORC2_HUMAN)

Names and origin

Protein names

Recommended name:
    VPS10 domain-containing receptor SorCS2

Gene names

Name:	SORCS2
Synonyms:	KIAA1329

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1159 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subcellular location	Membrane; Single-pass type I membrane protein.
Tissue specificity	Highly expressed in brain and kidney. Detected at low levels in heart, liver, small intestine, skeletal muscle and thymus.
Sequence similarities	Contains 6 BNR repeats. Contains 1 PKD domain.
Caution	The N-terminus of the protein was constructed in analogy to that of the mouse ortholog using the sequence of chromosome 4.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Repeat Signal Transmembrane
PTM	Glycoprotein
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	neuropeptide signaling pathway Ref.1 Non-traceable author statement. Source: UniProtKB
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	neuropeptide receptor activity Ref.1 Non-traceable author statement. Source: UniProtKB protein binding Ref.1 Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 50

50

Potential

Chain

51 – 1159

1109

VPS10 domain-containing receptor SorCS2

PRO_0000033172

Regions

Topological domain

51 – 1078

1028

Lumenal Potential

Transmembrane

1079 – 1099

21

Potential

Topological domain

1100 – 1159

60

Cytoplasmic Potential

Repeat

182 – 193

12

BNR 1

Repeat

232 – 243

12

BNR 2

Repeat

273 – 284

12

BNR 3

Repeat

468 – 479

12

BNR 4

Repeat

545 – 556

12

BNR 5

Repeat

587 – 598

12

BNR 6

Domain

786 – 876

91

PKD

Compositional bias

13 – 104

92

Pro-rich

Amino acid modifications

Glycosylation

158

1

N-linked (GlcNAc...) Potential

Glycosylation

328

1

N-linked (GlcNAc...) Potential

Glycosylation

362

1

N-linked (GlcNAc...) Potential

Glycosylation

600

1

N-linked (GlcNAc...) Potential

Glycosylation

830

1

N-linked (GlcNAc...) Potential

Glycosylation

891

1

N-linked (GlcNAc...) Potential

Glycosylation

902

1

N-linked (GlcNAc...) Potential

Natural variations

Natural variant

345

1

G → R: dbSNP rs34058821.

VAR_060109

Natural variant

595

1

T → I: dbSNP rs16840899.

VAR_057726

Natural variant

695

1

T → M: dbSNP rs16840892.

VAR_060110

Natural variant

745

1

T → I: dbSNP rs16840899.

VAR_060111

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

1159

Helix Strand Turn

Details...

Beta strand

782 – 789

8

Beta strand

800 – 808

9

Beta strand

815 – 819

5

Beta strand

821 – 823

3

Beta strand

825 – 830

6

Helix

831 – 834

4

Beta strand

838 – 840

3

Beta strand

848 – 855

8

Beta strand

860 – 867

8

Sequences

	Sequence		Length	Mass (Da)
	Q96PQ0-1 [UniParc]. Last modified December 13, 2002. Version 2. Checksum: 5C4FC4608C5BF872	FASTA	1,159	128,162
	10 20 30 40 50 60 MAHRGPSRAS KGPGPTARAP SPGAPPPPRS PRSRPLLLLL LLLGACGAAG RSPEPGRLGP 70 80 90 100 110 120 HAQLTRVPRS PPAGRAEPGG GEDRQARGTE PGAPGPSPGP APGPGEDGAP AAGYRRWERA 130 140 150 160 170 180 APLAGVASRA QVSLISTSFV LKGDATHNQA MVHWTGENSS VILILTKYYH ADMGKVLESS 190 200 210 220 230 240 LWRSSDFGTS YTKLTLQPGV TTVIDNFYIC PTNKRKVILV SSSLSDRDQS LFLSADEGAT 250 260 270 280 290 300 FQKQPIPFFV ETLIFHPKEE DKVLAYTKES KLYVSSDLGK KWTLLQERVT KDHVFWSVSG 310 320 330 340 350 360 VDADPDLVHV EAQDLGGDFR YVTCAIHNCS EKMLTAPFAG PIDHGSLTVQ DDYIFFKATS 370 380 390 400 410 420 ANQTKYYVSY RRNEFVLMKL PKYALPKDLQ IISTDESQVF VAVQEWYQMD TYNLYQSDPR 430 440 450 460 470 480 GVRYALVLQD VRSSRQAEES VLIDILEVRG VKGVFLANQK IDGKVMTLIT YNKGRDWDYL 490 500 510 520 530 540 RPPSMDMNGK PTNCKPPDCH LHLHLRWADN PYVSGTVHTK DTAPGLIMGA GNLGSQLVEY 550 560 570 580 590 600 KEEMYITSDC GHTWRQVFEE EHHILYLDHG GVIVAIKDTS IPLKILKFSV DEGLTWSTHN 610 620 630 640 650 660 FTSTSVFVDG LLSEPGDETL VMTVFGHISF RSDWELVKVD FRPSFSRQCG EEDYSSWELS 670 680 690 700 710 720 NLQGDRCIMG QQRSFRKRKS TSWCIKGRSF TSALTSRVCE CRDSDFLCDY GFERSPSSES 730 740 750 760 770 780 STNKCSANFW FNPLSPPDDC ALGQTYTSSL GYRKVVSNVC EGGVDMQQSQ VQLQCPLTPP 790 800 810 820 830 840 RGLQVSIQGE AVAVRPGEDV LFVVRQEQGD VLTTKYQVDL GDGFKAMYVN LTLTGEPIRH 850 860 870 880 890 900 RYESPGIYRV SVRAENTAGH DEAVLFVQVN SPLQALYLEV VPVIGLNQEV NLTAVLLPLN 910 920 930 940 950 960 PNLTVFYWWI GHSLQPLLSL DNSVTTRFSD TGDVRVTVQA ACGNSVLQDS RVLRVLDQFQ 970 980 990 1000 1010 1020 VMPLQFSKEL DAYNPNTPEW REDVGLVVTR LLSKETSVPQ ELLVTVVKPG LPTLADLYVL 1030 1040 1050 1060 1070 1080 LPPPRPTRKR SLSSDKRLAA IQQVLNAQKI SFLLRGGVRV LVALRDTGTG AEQLGGGGGY 1090 1100 1110 1120 1130 1140 WAVVVLFVIG LFAAGAFILY KFKRKRPGRT VYAQMHNEKE QEMTSPVSHS EDVQGAVQGN 1150 HSGVVLSINS REMHSYLVS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genes for the human VPS10 domain-containing receptors are large and contain many small exons." Hampe W., Rezgaoui M., Hermans-Borgmeyer I., Schaller H.C. Hum. Genet. 108:529-536(2001) [PubMed: 11499680] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 35-451.
[2]	"Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O. DNA Res. 7:65-73(2000) [PubMed: 10718198] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 253-1159. Tissue: Brain.
[3]	"Solution structure of the PKD domain from human VPS10 domain-containing receptor SORCS2." RIKEN structural genomics initiative (RSGI) Submitted (NOV-2004) to the PDB data bank Cited for: STRUCTURE BY NMR OF 760-869.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF286190 mRNA. Translation: AAL04014.1.
AB037750 mRNA. Translation: BAA92567.1.
AC097382 Genomic DNA. No translation available.

IPI

IPI00044600.

RefSeq

NP_065828.2.

UniGene

Hs.479099

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1WGO	NMR	-	A	760-869	[»]

SMR

Q96PQ0. Positions 168-285.

ModBase

Search...

Protein-protein interaction databases

STRING

Q96PQ0.

Proteomic databases

PRIDE

Q96PQ0.

Genome annotation databases

Ensembl

ENST00000403286; ENSP00000384595; ENSG00000184985; Homo sapiens. [Genome view]

GeneID

57537.

KEGG

hsa:57537.

UCSC

uc003gkb.2. human.

Organism-specific databases

CTD

57537.

GeneCards

GC04P007312.

H-InvDB

HIX0004076.

HGNC

HGNC:16698. SORCS2.

MIM

606284. gene.

PharmGKB

PA134902026.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

prNOG16195.

HOGENOM

HBG445080.

HOVERGEN

Q96PQ0.

Gene expression databases

ArrayExpress

Q96PQ0.

Bgee

Q96PQ0.

CleanEx

HS_SORCS2.

Genevestigator

Q96PQ0.

Family and domain databases

InterPro

IPR000601. PKD.
IPR006581. VPS10.
[Graphical view]

Pfam

PF00801. PKD. 1 hit.
[Graphical view]

SMART

SM00089. PKD. 1 hit.
SM00602. VPS10. 1 hit.
[Graphical view]

PROSITE

PS50093. PKD. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

63960.

SOURCE

Search...

Entry information

Entry name

SORC2_HUMAN

Accession

Primary (citable) accession number: Q96PQ0
Secondary accession number(s): Q9P2L7

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 13, 2002
Last sequence update:	December 13, 2002
Last modified:	January 19, 2010
This is version 70 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.