VPS10 domain-containing receptor SorCS2 precursor - Homo sapiens (Human)

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Q96PQ0 (SORC2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 86. History...

Clusters with 100%, 90%, 50% identity |

Documents (6) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
VPS10 domain-containing receptor SorCS2

Gene names

Name:	SORCS2
Synonyms:	KIAA1329

Organism

Homo sapiens (Human)

Taxonomic identifier

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1159 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Membrane; Single-pass type I membrane protein.
Tissue specificity	Highly expressed in brain and kidney. Detected at low levels in heart, liver, small intestine, skeletal muscle and thymus.
Sequence similarities	Belongs to the VPS10-related sortilin family. SORCS subfamily. Contains 6 BNR repeats. Contains 1 PKD domain.
Caution	The N-terminus of the protein was constructed in analogy to that of the mouse ortholog using the sequence of chromosome 4.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Repeat Signal Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	neuropeptide receptor activity Non-traceable author statement Ref.2. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

50

Potential

Chain

1109

VPS10 domain-containing receptor SorCS2

PRO_0000033172

Regions

Topological domain

1028

Lumenal Potential

Transmembrane

21

Helical; Potential

Topological domain

60

Cytoplasmic Potential

Repeat

12

BNR 1

Repeat

12

BNR 2

Repeat

12

BNR 3

Repeat

12

BNR 4

Repeat

12

BNR 5

Repeat

12

BNR 6

Domain

91

PKD

Compositional bias

92

Pro-rich

Amino acid modifications

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Natural variations

Natural variant

1

G → R.
Corresponds to variant rs34058821 [ dbSNP | Ensembl ].

VAR_060109

Natural variant

1

T → M.
Corresponds to variant rs16840892 [ dbSNP | Ensembl ].

VAR_060110

Natural variant

1

T → I.
Corresponds to variant rs16840899 [ dbSNP | Ensembl ].

VAR_060111

Experimental info

Sequence conflict

1

S → P in BAA92567. Ref.3

Secondary structure

1

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1159

Helix Strand Turn

Sequences

Sequence

Length

Mass (Da)

Tools

Q96PQ0 [UniParc].

Last modified May 18, 2010. Version 3.
Checksum: 61DEE8EF428B8B40
Show »

1,159

128,152

        10         20         30         40         50         60 
MAHRGPSRAS KGPGPTARAP SPGAPPPPRS PRSRPLLLLL LLLGACGAAG RSPEPGRLGP 

        70         80         90        100        110        120 
HAQLTRVPRS PPAGRAEPGG GEDRQARGTE PGAPGPSPGP APGPGEDGAP AAGYRRWERA 

       130        140        150        160        170        180 
APLAGVASRA QVSLISTSFV LKGDATHNQA MVHWTGENSS VILILTKYYH ADMGKVLESS 

       190        200        210        220        230        240 
LWRSSDFGTS YTKLTLQPGV TTVIDNFYIC PTNKRKVILV SSSLSDRDQS LFLSADEGAT 

       250        260        270        280        290        300 
FQKQPIPFFV ETLIFHPKEE DKVLAYTKES KLYVSSDLGK KWTLLQERVT KDHVFWSVSG 

       310        320        330        340        350        360 
VDADPDLVHV EAQDLGGDFR YVTCAIHNCS EKMLTAPFAG PIDHGSLTVQ DDYIFFKATS 

       370        380        390        400        410        420 
ANQTKYYVSY RRNEFVLMKL PKYALPKDLQ IISTDESQVF VAVQEWYQMD TYNLYQSDPR 

       430        440        450        460        470        480 
GVRYALVLQD VRSSRQAEES VLIDILEVRG VKGVFLANQK IDGKVMTLIT YNKGRDWDYL 

       490        500        510        520        530        540 
RPPSMDMNGK PTNCKPPDCH LHLHLRWADN PYVSGTVHTK DTAPGLIMGA GNLGSQLVEY 

       550        560        570        580        590        600 
KEEMYITSDC GHTWRQVFEE EHHILYLDHG GVIVAIKDTS IPLKILKFSV DEGLTWSTHN 

       610        620        630        640        650        660 
FTSTSVFVDG LLSEPGDETL VMTVFGHISF RSDWELVKVD FRPSFSRQCG EEDYSSWELS 

       670        680        690        700        710        720 
NLQGDRCIMG QQRSFRKRKS TSWCIKGRSF TSALTSRVCE CRDSDFLCDY GFERSSSSES 

       730        740        750        760        770        780 
STNKCSANFW FNPLSPPDDC ALGQTYTSSL GYRKVVSNVC EGGVDMQQSQ VQLQCPLTPP 

       790        800        810        820        830        840 
RGLQVSIQGE AVAVRPGEDV LFVVRQEQGD VLTTKYQVDL GDGFKAMYVN LTLTGEPIRH 

       850        860        870        880        890        900 
RYESPGIYRV SVRAENTAGH DEAVLFVQVN SPLQALYLEV VPVIGLNQEV NLTAVLLPLN 

       910        920        930        940        950        960 
PNLTVFYWWI GHSLQPLLSL DNSVTTRFSD TGDVRVTVQA ACGNSVLQDS RVLRVLDQFQ 

       970        980        990       1000       1010       1020 
VMPLQFSKEL DAYNPNTPEW REDVGLVVTR LLSKETSVPQ ELLVTVVKPG LPTLADLYVL 

      1030       1040       1050       1060       1070       1080 
LPPPRPTRKR SLSSDKRLAA IQQVLNAQKI SFLLRGGVRV LVALRDTGTG AEQLGGGGGY 

      1090       1100       1110       1120       1130       1140 
WAVVVLFVIG LFAAGAFILY KFKRKRPGRT VYAQMHNEKE QEMTSPVSHS EDVQGAVQGN 

      1150 
HSGVVLSINS REMHSYLVS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. Wilson R.K. Nature 434:724-731(2005) [PubMed: 15815621] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The genes for the human VPS10 domain-containing receptors are large and contain many small exons." Hampe W., Rezgaoui M., Hermans-Borgmeyer I., Schaller H.C. Hum. Genet. 108:529-536(2001) [PubMed: 11499680] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 35-451.
[3]	"Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O. DNA Res. 7:65-73(2000) [PubMed: 10718198] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 253-1159. Tissue: Brain.
[4]	"Solution structure of the PKD domain from human VPS10 domain-containing receptor SORCS2." RIKEN structural genomics initiative (RSGI) Submitted (NOV-2004) to the PDB data bank Cited for: STRUCTURE BY NMR OF 760-869.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AC004169 Genomic DNA. No translation available.
AC080003 Genomic DNA. No translation available.
AC097382 Genomic DNA. No translation available.
AC112710 Genomic DNA. No translation available.
AC116316 Genomic DNA. No translation available.
AF286190 mRNA. Translation: AAL04014.1.
AB037750 mRNA. Translation: BAA92567.1.

IPI

RefSeq

NP_065828.2. NM_020777.2.

UniGene

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1WGO	NMR	-	A	760-869	[»]

ProteinModelPortal

SMR

Q96PQ0. Positions 179-244, 250-289, 543-600, 764-872.

ModBase

Protein-protein interaction databases

STRING

Polymorphism databases

DMDM

Proteomic databases

PRIDE

Protocols and materials databases

StructuralBiologyKnowledgebase

Genome annotation databases

Ensembl

ENST00000403286; ENSP00000384595; ENSG00000184985.

GeneID

KEGG

UCSC

uc003gkb.2. human.

Organism-specific databases

CTD

GeneCards

H-InvDB

HGNC

HGNC:16698. SORCS2.

MIM

606284. gene.

neXtProt

PharmGKB

HUGE

GenAtlas

Phylogenomic databases

eggNOG

GeneTree

ENSGT00510000046443.

HOGENOM

HOVERGEN

OMA

PhylomeDB

Gene expression databases

ArrayExpress

Bgee

CleanEx

Genevestigator

Family and domain databases

InterPro

IPR022409. PKD/Chitinase_dom.
IPR000601. PKD_dom.
IPR006581. VPS10.
[Graphical view]

Gene3D

G3DSA:2.60.40.670. PKD. 1 hit.

Pfam

PF00801. PKD. 1 hit.
[Graphical view]

SMART

SM00089. PKD. 1 hit.
SM00602. VPS10. 1 hit.
[Graphical view]

SUPFAM

SSF49299. PKD. 1 hit.

PROSITE

PS50093. PKD. 1 hit.
[Graphical view]

ProtoNet

Other

NextBio

SOURCE

Entry information

Entry name

SORC2_HUMAN

Accession

Primary (citable) accession number: Q96PQ0
Secondary accession number(s): Q9P2L7

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 13, 2002
Last sequence update:	May 18, 2010
Last modified:	January 25, 2012
This is version 86 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents