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Q96PN8

- TSSK3_HUMAN

UniProt

Q96PN8 - TSSK3_HUMAN

Protein

Testis-specific serine/threonine-protein kinase 3

Gene

TSSK3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    May be involved in a signaling pathway during male germ cell development or mature sperm function.

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Cofactori

    Magnesium.By similarity

    Enzyme regulationi

    Activated by phosphorylation on Thr-168, potentially by autophosphorylation.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei39 – 391ATPPROSITE-ProRule annotation
    Active sitei134 – 1341Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi16 – 249ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB
    2. magnesium ion binding Source: UniProtKB
    3. protein serine/threonine kinase activity Source: UniProtKB

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. multicellular organismal development Source: UniProtKB-KW
    3. protein phosphorylation Source: UniProtKB
    4. spermatogenesis Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    Differentiation, Spermatogenesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    SignaLinkiQ96PN8.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Testis-specific serine/threonine-protein kinase 3 (EC:2.7.11.1)
    Short name:
    TSK-3
    Short name:
    TSSK-3
    Short name:
    Testis-specific kinase 3
    Alternative name(s):
    Serine/threonine-protein kinase 22C
    Gene namesi
    Name:TSSK3
    Synonyms:SPOGA3, STK22C
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:15473. TSSK3.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37964.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 268268Testis-specific serine/threonine-protein kinase 3PRO_0000086770Add
    BLAST

    Post-translational modificationi

    Autophosphorylated.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ96PN8.
    PRIDEiQ96PN8.

    PTM databases

    PhosphoSiteiQ96PN8.

    Expressioni

    Gene expression databases

    ArrayExpressiQ96PN8.
    BgeeiQ96PN8.
    CleanExiHS_TSSK3.
    GenevestigatoriQ96PN8.

    Organism-specific databases

    HPAiHPA037515.

    Interactioni

    Protein-protein interaction databases

    BioGridi123564. 6 interactions.
    IntActiQ96PN8. 6 interactions.
    STRINGi9606.ENSP00000362634.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96PN8.
    SMRiQ96PN8. Positions 10-265.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini10 – 265256Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000233016.
    HOVERGENiHBG101110.
    InParanoidiQ96PN8.
    KOiK08811.
    OMAiKGDIWSM.
    PhylomeDBiQ96PN8.
    TreeFamiTF352374.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96PN8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEDFLLSNGY QLGKTIGEGT YSKVKEAFSK KHQRKVAIKV IDKMGGPEEF    50
    IQRFLPRELQ IVRTLDHKNI IQVYEMLESA DGKICLVMEL AEGGDVFDCV 100
    LNGGPLPESR AKALFRQMVE AIRYCHGCGV AHRDLKCENA LLQGFNLKLT 150
    DFGFAKVLPK SHRELSQTFC GSTAYAAPEV LQGIPHDSKK GDVWSMGVVL 200
    YVMLCASLPF DDTDIPKMLW QQQKGVSFPT HLSISADCQD LLKRLLEPDM 250
    ILRPSIEEVS WHPWLAST 268
    Length:268
    Mass (Da):30,102
    Last modified:December 1, 2001 - v1
    Checksum:iEF91F91DD216F671
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti71 – 711I → V.
    Corresponds to variant rs35508255 [ dbSNP | Ensembl ].
    VAR_051678
    Natural varianti140 – 1401A → T.1 Publication
    Corresponds to variant rs55786268 [ dbSNP | Ensembl ].
    VAR_041245
    Natural varianti235 – 2351S → L.1 Publication
    Corresponds to variant rs35457991 [ dbSNP | Ensembl ].
    VAR_041246

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF296450 mRNA. Translation: AAK97141.1.
    AY048701 Transcribed RNA. Translation: AAL02128.1.
    AL109945 Genomic DNA. Translation: CAI22888.1.
    CH471059 Genomic DNA. Translation: EAX07532.1.
    BC035354 mRNA. Translation: AAH35354.1.
    CCDSiCCDS362.1.
    RefSeqiNP_443073.1. NM_052841.3.
    UniGeneiHs.512763.

    Genome annotation databases

    EnsembliENST00000373534; ENSP00000362634; ENSG00000162526.
    GeneIDi81629.
    KEGGihsa:81629.
    UCSCiuc001bvf.3. human.

    Polymorphism databases

    DMDMi30316270.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF296450 mRNA. Translation: AAK97141.1 .
    AY048701 Transcribed RNA. Translation: AAL02128.1 .
    AL109945 Genomic DNA. Translation: CAI22888.1 .
    CH471059 Genomic DNA. Translation: EAX07532.1 .
    BC035354 mRNA. Translation: AAH35354.1 .
    CCDSi CCDS362.1.
    RefSeqi NP_443073.1. NM_052841.3.
    UniGenei Hs.512763.

    3D structure databases

    ProteinModelPortali Q96PN8.
    SMRi Q96PN8. Positions 10-265.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123564. 6 interactions.
    IntActi Q96PN8. 6 interactions.
    STRINGi 9606.ENSP00000362634.

    PTM databases

    PhosphoSitei Q96PN8.

    Polymorphism databases

    DMDMi 30316270.

    Proteomic databases

    PaxDbi Q96PN8.
    PRIDEi Q96PN8.

    Protocols and materials databases

    DNASUi 81629.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000373534 ; ENSP00000362634 ; ENSG00000162526 .
    GeneIDi 81629.
    KEGGi hsa:81629.
    UCSCi uc001bvf.3. human.

    Organism-specific databases

    CTDi 81629.
    GeneCardsi GC01P032827.
    H-InvDB HIX0000372.
    HGNCi HGNC:15473. TSSK3.
    HPAi HPA037515.
    MIMi 607660. gene.
    neXtProti NX_Q96PN8.
    PharmGKBi PA37964.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000233016.
    HOVERGENi HBG101110.
    InParanoidi Q96PN8.
    KOi K08811.
    OMAi KGDIWSM.
    PhylomeDBi Q96PN8.
    TreeFami TF352374.

    Enzyme and pathway databases

    SignaLinki Q96PN8.

    Miscellaneous databases

    ChiTaRSi TSSK3. human.
    GenomeRNAii 81629.
    NextBioi 72014.
    PROi Q96PN8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96PN8.
    Bgeei Q96PN8.
    CleanExi HS_TSSK3.
    Genevestigatori Q96PN8.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and chromosomal localization of a gene encoding a novel serine/threonine kinase belonging to the subfamily of testis-specific kinases."
      Visconti P.E., Hao Z., Purdon M.A., Stein P., Balsara B.R., Testa J.R., Herr J.C., Moss S.B., Kopf G.S.
      Genomics 77:163-170(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Testis.
    2. "Cloning and characterization of a novel human TSSK3 gene."
      Mao Y., Xie Y., Jiang M.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Fetal brain.
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    6. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS [LARGE SCALE ANALYSIS] THR-140 AND LEU-235.

    Entry informationi

    Entry nameiTSSK3_HUMAN
    AccessioniPrimary (citable) accession number: Q96PN8
    Secondary accession number(s): Q5TEE5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 30, 2003
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 117 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    The mouse homolog is Stk22d.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3