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Protein

Testis-specific serine/threonine-protein kinase 3

Gene

TSSK3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in a signaling pathway during male germ cell development or mature sperm function.

Miscellaneous

The mouse homolog is Stk22d.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Mg2+By similarity

Enzyme regulationi

Activated by phosphorylation on Thr-168, potentially by autophosphorylation.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei39ATPPROSITE-ProRule annotation1
Active sitei134Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi16 – 24ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Kinase, Serine/threonine-protein kinase, Transferase
Biological processDifferentiation, Spermatogenesis
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ96PN8.

Names & Taxonomyi

Protein namesi
Recommended name:
Testis-specific serine/threonine-protein kinase 3 (EC:2.7.11.1)
Short name:
TSK-3
Short name:
TSSK-3
Short name:
Testis-specific kinase 3
Alternative name(s):
Serine/threonine-protein kinase 22C
Gene namesi
Name:TSSK3
Synonyms:SPOGA3, STK22C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:15473. TSSK3.

Subcellular locationi

GO - Cellular componenti

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000162526.
PharmGKBiPA37964.

Chemistry databases

ChEMBLiCHEMBL3414416.

Polymorphism and mutation databases

BioMutaiTSSK3.
DMDMi30316270.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000867701 – 268Testis-specific serine/threonine-protein kinase 3Add BLAST268

Post-translational modificationi

Autophosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ96PN8.
PaxDbiQ96PN8.
PeptideAtlasiQ96PN8.
PRIDEiQ96PN8.

PTM databases

iPTMnetiQ96PN8.
PhosphoSitePlusiQ96PN8.

Expressioni

Gene expression databases

BgeeiENSG00000162526.
CleanExiHS_TSSK3.
ExpressionAtlasiQ96PN8. baseline and differential.
GenevisibleiQ96PN8. HS.

Organism-specific databases

HPAiHPA037516.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi123564. 19 interactors.
IntActiQ96PN8. 48 interactors.
STRINGi9606.ENSP00000362634.

Chemistry databases

BindingDBiQ96PN8.

Structurei

3D structure databases

ProteinModelPortaliQ96PN8.
SMRiQ96PN8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 265Protein kinasePROSITE-ProRule annotationAdd BLAST256

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0583. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00770000120521.
HOGENOMiHOG000233016.
HOVERGENiHBG101110.
InParanoidiQ96PN8.
KOiK08811.
OMAiISSECQD.
OrthoDBiEOG091G0EZI.
PhylomeDBiQ96PN8.
TreeFamiTF352374.

Family and domain databases

InterProiView protein in InterPro
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
PfamiView protein in Pfam
PF00069. Pkinase. 1 hit.
SMARTiView protein in SMART
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96PN8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDFLLSNGY QLGKTIGEGT YSKVKEAFSK KHQRKVAIKV IDKMGGPEEF
60 70 80 90 100
IQRFLPRELQ IVRTLDHKNI IQVYEMLESA DGKICLVMEL AEGGDVFDCV
110 120 130 140 150
LNGGPLPESR AKALFRQMVE AIRYCHGCGV AHRDLKCENA LLQGFNLKLT
160 170 180 190 200
DFGFAKVLPK SHRELSQTFC GSTAYAAPEV LQGIPHDSKK GDVWSMGVVL
210 220 230 240 250
YVMLCASLPF DDTDIPKMLW QQQKGVSFPT HLSISADCQD LLKRLLEPDM
260
ILRPSIEEVS WHPWLAST
Length:268
Mass (Da):30,102
Last modified:December 1, 2001 - v1
Checksum:iEF91F91DD216F671
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05167871I → V. Corresponds to variant dbSNP:rs35508255Ensembl.1
Natural variantiVAR_041245140A → T1 PublicationCorresponds to variant dbSNP:rs55786268Ensembl.1
Natural variantiVAR_041246235S → L1 PublicationCorresponds to variant dbSNP:rs35457991Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF296450 mRNA. Translation: AAK97141.1.
AY048701 Transcribed RNA. Translation: AAL02128.1.
AL109945 Genomic DNA. Translation: CAI22888.1.
CH471059 Genomic DNA. Translation: EAX07532.1.
BC035354 mRNA. Translation: AAH35354.1.
CCDSiCCDS362.1.
RefSeqiNP_443073.1. NM_052841.3.
UniGeneiHs.512763.

Genome annotation databases

EnsembliENST00000373534; ENSP00000362634; ENSG00000162526.
GeneIDi81629.
KEGGihsa:81629.
UCSCiuc001bvf.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF296450 mRNA. Translation: AAK97141.1.
AY048701 Transcribed RNA. Translation: AAL02128.1.
AL109945 Genomic DNA. Translation: CAI22888.1.
CH471059 Genomic DNA. Translation: EAX07532.1.
BC035354 mRNA. Translation: AAH35354.1.
CCDSiCCDS362.1.
RefSeqiNP_443073.1. NM_052841.3.
UniGeneiHs.512763.

3D structure databases

ProteinModelPortaliQ96PN8.
SMRiQ96PN8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123564. 19 interactors.
IntActiQ96PN8. 48 interactors.
STRINGi9606.ENSP00000362634.

Chemistry databases

BindingDBiQ96PN8.
ChEMBLiCHEMBL3414416.

PTM databases

iPTMnetiQ96PN8.
PhosphoSitePlusiQ96PN8.

Polymorphism and mutation databases

BioMutaiTSSK3.
DMDMi30316270.

Proteomic databases

MaxQBiQ96PN8.
PaxDbiQ96PN8.
PeptideAtlasiQ96PN8.
PRIDEiQ96PN8.

Protocols and materials databases

DNASUi81629.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373534; ENSP00000362634; ENSG00000162526.
GeneIDi81629.
KEGGihsa:81629.
UCSCiuc001bvf.4. human.

Organism-specific databases

CTDi81629.
GeneCardsiTSSK3.
H-InvDBiHIX0000372.
HGNCiHGNC:15473. TSSK3.
HPAiHPA037516.
MIMi607660. gene.
neXtProtiNX_Q96PN8.
OpenTargetsiENSG00000162526.
PharmGKBiPA37964.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0583. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00770000120521.
HOGENOMiHOG000233016.
HOVERGENiHBG101110.
InParanoidiQ96PN8.
KOiK08811.
OMAiISSECQD.
OrthoDBiEOG091G0EZI.
PhylomeDBiQ96PN8.
TreeFamiTF352374.

Enzyme and pathway databases

SignaLinkiQ96PN8.

Miscellaneous databases

ChiTaRSiTSSK3. human.
GenomeRNAii81629.
PROiPR:Q96PN8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000162526.
CleanExiHS_TSSK3.
ExpressionAtlasiQ96PN8. baseline and differential.
GenevisibleiQ96PN8. HS.

Family and domain databases

InterProiView protein in InterPro
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
PfamiView protein in Pfam
PF00069. Pkinase. 1 hit.
SMARTiView protein in SMART
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTSSK3_HUMAN
AccessioniPrimary (citable) accession number: Q96PN8
Secondary accession number(s): Q5TEE5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: December 1, 2001
Last modified: March 15, 2017
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.