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Q96PN8

- TSSK3_HUMAN

UniProt

Q96PN8 - TSSK3_HUMAN

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Protein

Testis-specific serine/threonine-protein kinase 3

Gene

TSSK3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

May be involved in a signaling pathway during male germ cell development or mature sperm function.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Mg2+By similarity

Enzyme regulationi

Activated by phosphorylation on Thr-168, potentially by autophosphorylation.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei39 – 391ATPPROSITE-ProRule annotation
Active sitei134 – 1341Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi16 – 249ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB
  2. magnesium ion binding Source: UniProtKB
  3. protein serine/threonine kinase activity Source: UniProtKB

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. multicellular organismal development Source: UniProtKB-KW
  3. protein phosphorylation Source: UniProtKB
  4. spermatogenesis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Differentiation, Spermatogenesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ96PN8.

Names & Taxonomyi

Protein namesi
Recommended name:
Testis-specific serine/threonine-protein kinase 3 (EC:2.7.11.1)
Short name:
TSK-3
Short name:
TSSK-3
Short name:
Testis-specific kinase 3
Alternative name(s):
Serine/threonine-protein kinase 22C
Gene namesi
Name:TSSK3
Synonyms:SPOGA3, STK22C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:15473. TSSK3.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37964.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 268268Testis-specific serine/threonine-protein kinase 3PRO_0000086770Add
BLAST

Post-translational modificationi

Autophosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ96PN8.
PRIDEiQ96PN8.

PTM databases

PhosphoSiteiQ96PN8.

Expressioni

Gene expression databases

BgeeiQ96PN8.
CleanExiHS_TSSK3.
ExpressionAtlasiQ96PN8. baseline and differential.
GenevestigatoriQ96PN8.

Organism-specific databases

HPAiHPA037515.

Interactioni

Protein-protein interaction databases

BioGridi123564. 6 interactions.
IntActiQ96PN8. 6 interactions.
STRINGi9606.ENSP00000362634.

Structurei

3D structure databases

ProteinModelPortaliQ96PN8.
SMRiQ96PN8. Positions 10-265.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 265256Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00770000120521.
HOGENOMiHOG000233016.
HOVERGENiHBG101110.
InParanoidiQ96PN8.
KOiK08811.
OMAiKGDIWSM.
PhylomeDBiQ96PN8.
TreeFamiTF352374.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96PN8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEDFLLSNGY QLGKTIGEGT YSKVKEAFSK KHQRKVAIKV IDKMGGPEEF
60 70 80 90 100
IQRFLPRELQ IVRTLDHKNI IQVYEMLESA DGKICLVMEL AEGGDVFDCV
110 120 130 140 150
LNGGPLPESR AKALFRQMVE AIRYCHGCGV AHRDLKCENA LLQGFNLKLT
160 170 180 190 200
DFGFAKVLPK SHRELSQTFC GSTAYAAPEV LQGIPHDSKK GDVWSMGVVL
210 220 230 240 250
YVMLCASLPF DDTDIPKMLW QQQKGVSFPT HLSISADCQD LLKRLLEPDM
260
ILRPSIEEVS WHPWLAST
Length:268
Mass (Da):30,102
Last modified:December 1, 2001 - v1
Checksum:iEF91F91DD216F671
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti71 – 711I → V.
Corresponds to variant rs35508255 [ dbSNP | Ensembl ].
VAR_051678
Natural varianti140 – 1401A → T.1 Publication
Corresponds to variant rs55786268 [ dbSNP | Ensembl ].
VAR_041245
Natural varianti235 – 2351S → L.1 Publication
Corresponds to variant rs35457991 [ dbSNP | Ensembl ].
VAR_041246

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF296450 mRNA. Translation: AAK97141.1.
AY048701 Transcribed RNA. Translation: AAL02128.1.
AL109945 Genomic DNA. Translation: CAI22888.1.
CH471059 Genomic DNA. Translation: EAX07532.1.
BC035354 mRNA. Translation: AAH35354.1.
CCDSiCCDS362.1.
RefSeqiNP_443073.1. NM_052841.3.
UniGeneiHs.512763.

Genome annotation databases

EnsembliENST00000373534; ENSP00000362634; ENSG00000162526.
GeneIDi81629.
KEGGihsa:81629.
UCSCiuc001bvf.3. human.

Polymorphism databases

DMDMi30316270.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF296450 mRNA. Translation: AAK97141.1 .
AY048701 Transcribed RNA. Translation: AAL02128.1 .
AL109945 Genomic DNA. Translation: CAI22888.1 .
CH471059 Genomic DNA. Translation: EAX07532.1 .
BC035354 mRNA. Translation: AAH35354.1 .
CCDSi CCDS362.1.
RefSeqi NP_443073.1. NM_052841.3.
UniGenei Hs.512763.

3D structure databases

ProteinModelPortali Q96PN8.
SMRi Q96PN8. Positions 10-265.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123564. 6 interactions.
IntActi Q96PN8. 6 interactions.
STRINGi 9606.ENSP00000362634.

PTM databases

PhosphoSitei Q96PN8.

Polymorphism databases

DMDMi 30316270.

Proteomic databases

PaxDbi Q96PN8.
PRIDEi Q96PN8.

Protocols and materials databases

DNASUi 81629.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000373534 ; ENSP00000362634 ; ENSG00000162526 .
GeneIDi 81629.
KEGGi hsa:81629.
UCSCi uc001bvf.3. human.

Organism-specific databases

CTDi 81629.
GeneCardsi GC01P032827.
H-InvDB HIX0000372.
HGNCi HGNC:15473. TSSK3.
HPAi HPA037515.
MIMi 607660. gene.
neXtProti NX_Q96PN8.
PharmGKBi PA37964.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00770000120521.
HOGENOMi HOG000233016.
HOVERGENi HBG101110.
InParanoidi Q96PN8.
KOi K08811.
OMAi KGDIWSM.
PhylomeDBi Q96PN8.
TreeFami TF352374.

Enzyme and pathway databases

SignaLinki Q96PN8.

Miscellaneous databases

ChiTaRSi TSSK3. human.
GenomeRNAii 81629.
NextBioi 72014.
PROi Q96PN8.
SOURCEi Search...

Gene expression databases

Bgeei Q96PN8.
CleanExi HS_TSSK3.
ExpressionAtlasi Q96PN8. baseline and differential.
Genevestigatori Q96PN8.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and chromosomal localization of a gene encoding a novel serine/threonine kinase belonging to the subfamily of testis-specific kinases."
    Visconti P.E., Hao Z., Purdon M.A., Stein P., Balsara B.R., Testa J.R., Herr J.C., Moss S.B., Kopf G.S.
    Genomics 77:163-170(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  2. "Cloning and characterization of a novel human TSSK3 gene."
    Mao Y., Xie Y., Jiang M.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fetal brain.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  6. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] THR-140 AND LEU-235.

Entry informationi

Entry nameiTSSK3_HUMAN
AccessioniPrimary (citable) accession number: Q96PN8
Secondary accession number(s): Q5TEE5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: December 1, 2001
Last modified: November 26, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The mouse homolog is Stk22d.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3