Q96PN7 (TREF1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transcriptional-regulating factor 1

Alternative name(s):
Breast cancer anti-estrogen resistance 2
Transcriptional-regulating protein 132
Zinc finger protein rapa
Zinc finger transcription factor TReP-132

Gene names

Name:	TRERF1
Synonyms:	BCAR2, RAPA, TREP132

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1200 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Activates transcription of CYP11A1. Interaction with CREBBP and EP300 results in a synergistic transcriptional activation of CYP11A1. Ref.1
Subunit structure	Interacts with CREBBP and EP300. Ref.1
Subcellular location	Nucleus Ref.1.
Tissue specificity	Highest expression was seen in thymus, testis and adrenal cortex, expressed also in the adrenal medulla, thyroid, and stomach. Highly expressed in steroidogenic JEG-3 and MCF-7 cells, low expression was seen in non-steroidogenic HepG2 and HK293 cells. Ref.1
Sequence similarities	Contains 3 C2H2-type zinc fingers. Contains 1 ELM2 domain. Contains 1 SANT domain.
Sequence caution	The sequence BAA92082.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Activator
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cholesterol catabolic process Non-traceable author statement Ref.1. Source: UniProtKB homeostatic process Non-traceable author statement Ref.1. Source: UniProtKB multicellular organismal development Non-traceable author statement Ref.1. Source: UniProtKB positive regulation of transcription, DNA-dependent Inferred from direct assay Ref.1. Source: UniProtKB regulation of hormone biosynthetic process Non-traceable author statement Ref.1. Source: UniProtKB steroid biosynthetic process Non-traceable author statement Ref.1. Source: UniProtKB
Cellular component	nucleus Inferred from direct assay Ref.1. Source: UniProtKB
Molecular function	DNA binding, bending Non-traceable author statement Ref.1. Source: UniProtKB RNA polymerase II transcription cofactor activity Non-traceable author statement Ref.1. Source: UniProtKB ligand-dependent nuclear receptor transcription coactivator activity Non-traceable author statement Ref.1. Source: UniProtKB sequence-specific DNA binding transcription factor activity Inferred from direct assay Ref.1. Source: UniProtKB transcription factor binding Inferred from physical interaction Ref.1. Source: UniProtKB zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96PN7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96PN7-2)

Also known as: Rapa-1;

The sequence of this isoform differs from the canonical sequence as follows:
     1-161: Missing.
     546-628: Missing.

Isoform 3 (identifier: Q96PN7-3)

Also known as: Rapa-2;

The sequence of this isoform differs from the canonical sequence as follows:
     1-161: Missing.
     546-628: Missing.
     1022-1022: A → ADCRCHVTPFLPQ

Isoform 4 (identifier: Q96PN7-4)

The sequence of this isoform differs from the canonical sequence as follows:
     546-628: Missing.

Note: Gene prediction based on EST data.

Isoform 5 (identifier: Q96PN7-5)

The sequence of this isoform differs from the canonical sequence as follows:
     546-628: Missing.
     1022-1022: A → ADCRCHVTPFLPQ

Note: Gene prediction based on EST data.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1200	1200	Transcriptional-regulating factor 1		PRO_0000197134
Regions
	Domain	779 – 870	92	ELM2
	Domain	885 – 936	52	SANT
	Zinc finger	512 – 534	23	C2H2-type 1
	Zinc finger	1013 – 1037	25	C2H2-type 2
	Zinc finger	1086 – 1108	23	C2H2-type 3
	Region	439 – 1200	762	Interacts with CREBBP
	Compositional bias	202 – 417	216	Gln-rich
	Compositional bias	553 – 749	197	Pro-rich
	Compositional bias	956 – 982	27	Glu-rich
Amino acid modifications
	Modified residue	491	1	Phosphoserine Ref.6
	Modified residue	767	1	Phosphothreonine Ref.7
	Modified residue	975	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	1 – 161	161	Missing in isoform 2 and isoform 3.		VSP_015644
	Alternative sequence	546 – 628	83	Missing in isoform 2, isoform 3, isoform 4 and isoform 5.		VSP_015645
	Alternative sequence	1022	1	A → ADCRCHVTPFLPQ in isoform 3 and isoform 5.		VSP_015646
	Natural variant	431	1	T → A. Corresponds to variant rs35162277 [ dbSNP | Ensembl ].		VAR_050197
	Natural variant	766	1	V → I. Corresponds to variant rs59159203 [ dbSNP | Ensembl ].		VAR_061362
	Natural variant	834	1	C → S. Corresponds to variant rs2295275 [ dbSNP | Ensembl ].		VAR_050198
	Natural variant	1019	1	N → T. Corresponds to variant rs35978318 [ dbSNP | Ensembl ].		VAR_050199
	Natural variant	1187	1	D → N. Corresponds to variant rs11751765 [ dbSNP | Ensembl ].		VAR_050200
Experimental info
	Sequence conflict	658	1	P → S in CAB88206. Ref.2
	Sequence conflict	658	1	P → S in CAB88207. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: B77057F46A73404F	FASTA	1,200	132,256
	10 20 30 40 50 60 MGDQQLYKTN HVAHGSENLF YQQPPLGVHS GLNHNYGNAV TGGGMDAPQA SPISPHFPQD 70 80 90 100 110 120 TRDGLGLPVG SKNLGQMDTS RQGGWGSHAG PGNHVQLRGN LANSNMMWGA PAQAEPTDGY 130 140 150 160 170 180 QYTYSQASEI RTQKLTSGVL HKLDSFTQVF ANQNLRIQVN NMAQVLHTQS AVMDGAPDSA 190 200 210 220 230 240 LRQLLSQKPM EPPAPAIPSR YQQVPQQPHP GFTGGLSKPA LQVGQHPTQG HLYYDYQQPL 250 260 270 280 290 300 AQVPVQGGQP LQAPQMLSQH MQQMQQHQYY PPQQQQQAGQ QRISMQEIQT QPQQIRPSQP 310 320 330 340 350 360 QPPPQQQQPQ QLQLQQRQGS MQIPQYYQPQ PMMQHLQEQQ QQQMHLQPPS YHRDPHQYTP 370 380 390 400 410 420 EQAHTVQLIP LGSMSQYYYQ EPQQPYSHPL YQQSHLSQHQ QREDSQLKTY SSDRQAQAML 430 440 450 460 470 480 SSHGDLGPPD TGMGDPASSD LTRVSSTLPH RPLLSPSGIH LNNMGPQHQQ LSPSAMWPQM 490 500 510 520 530 540 HLPDGRAQPG SPESSGQPKG AFGEQFDAKN KLTCSICLKE FKNLPALNGH MRSHGGMRAS 550 560 570 580 590 600 PNLKQEEGEK VLPPQPQPPL PPPPPPPPPP QLPPEAESLT PMVMPVSVPV KLLPPKPSSQ 610 620 630 640 650 660 GFTNSTVAAP SARDKPASSM SDDEMPVLEI PRKHQPSVPK AEEPLKTVQE KKKFRHRPEP 670 680 690 700 710 720 LFIPPPPSYN PNPAASYSGA TLYQSQLRSP RVLGDHLLLD PTHELPPYTP PPMLSPVRQG 730 740 750 760 770 780 SGLFSNVLIS GHGPGAHPQL PLTPLTPTPR VLLCRSNSID GSNVTVTPGP GEQTVDVEPR 790 800 810 820 830 840 INIGLRFQAE IPELQDISAL AQDTHKATLV WKPWPELENH DLQQRVENLL NLCCSSALPG 850 860 870 880 890 900 GGTNSEFALH SLFEAKGDVM VALEMLLLRK PVRLKCHPLA NYHYAGSDKW TSLERKLFNK 910 920 930 940 950 960 ALATYSKDFI FVQKMVKSKT VAQCVEYYYT WKKIMRLGRK HRTRLAEIID DCVTSEEEEE 970 980 990 1000 1010 1020 LEEEEEEDPE EDRKSTKEEE SEVPKSPEPP PVPVLAPTEG PPLQALGQPS GSFICEMPNC 1030 1040 1050 1060 1070 1080 GAVFSSRQAL NGHARIHGGT NQVTKARGAI PSGKQKPGGT QSGYCSVKSS PSHSTTSGET 1090 1100 1110 1120 1130 1140 DPTTIFPCKE CGKVFFKIKS RNAHMKTHRQ QEEQQRQKAQ KAAFAAEMAA TIERTTGPVG 1150 1160 1170 1180 1190 1200 APGLLPLDQL SLIKPIKDVD ILDDDVVQQL GGVMEEAEVV DTDLLLDDQD SVLLQGDAEL
	Isoform 2 (Rapa-1) [UniParc]. Checksum: 7BE77C8D7B10CCF9	FASTA	956	106,264
	10 20 30 40 50 60 MAQVLHTQSA VMDGAPDSAL RQLLSQKPME PPAPAIPSRY QQVPQQPHPG FTGGLSKPAL 70 80 90 100 110 120 QVGQHPTQGH LYYDYQQPLA QVPVQGGQPL QAPQMLSQHM QQMQQHQYYP PQQQQQAGQQ 130 140 150 160 170 180 RISMQEIQTQ PQQIRPSQPQ PPPQQQQPQQ LQLQQRQGSM QIPQYYQPQP MMQHLQEQQQ 190 200 210 220 230 240 QQMHLQPPSY HRDPHQYTPE QAHTVQLIPL GSMSQYYYQE PQQPYSHPLY QQSHLSQHQQ 250 260 270 280 290 300 REDSQLKTYS SDRQAQAMLS SHGDLGPPDT GMGDPASSDL TRVSSTLPHR PLLSPSGIHL 310 320 330 340 350 360 NNMGPQHQQL SPSAMWPQMH LPDGRAQPGS PESSGQPKGA FGEQFDAKNK LTCSICLKEF 370 380 390 400 410 420 KNLPALNGHM RSHGGMRASP NLKQEIPRKH QPSVPKAEEP LKTVQEKKKF RHRPEPLFIP 430 440 450 460 470 480 PPPSYNPNPA ASYSGATLYQ SQLRSPRVLG DHLLLDPTHE LPPYTPPPML SPVRQGSGLF 490 500 510 520 530 540 SNVLISGHGP GAHPQLPLTP LTPTPRVLLC RSNSIDGSNV TVTPGPGEQT VDVEPRINIG 550 560 570 580 590 600 LRFQAEIPEL QDISALAQDT HKATLVWKPW PELENHDLQQ RVENLLNLCC SSALPGGGTN 610 620 630 640 650 660 SEFALHSLFE AKGDVMVALE MLLLRKPVRL KCHPLANYHY AGSDKWTSLE RKLFNKALAT 670 680 690 700 710 720 YSKDFIFVQK MVKSKTVAQC VEYYYTWKKI MRLGRKHRTR LAEIIDDCVT SEEEEELEEE 730 740 750 760 770 780 EEEDPEEDRK STKEEESEVP KSPEPPPVPV LAPTEGPPLQ ALGQPSGSFI CEMPNCGAVF 790 800 810 820 830 840 SSRQALNGHA RIHGGTNQVT KARGAIPSGK QKPGGTQSGY CSVKSSPSHS TTSGETDPTT 850 860 870 880 890 900 IFPCKECGKV FFKIKSRNAH MKTHRQQEEQ QRQKAQKAAF AAEMAATIER TTGPVGAPGL 910 920 930 940 950 LPLDQLSLIK PIKDVDILDD DVVQQLGGVM EEAEVVDTDL LLDDQDSVLL QGDAEL
	Isoform 3 (Rapa-2) [UniParc]. Checksum: AC9777B930C5BD82	FASTA	968	107,662
	10 20 30 40 50 60 MAQVLHTQSA VMDGAPDSAL RQLLSQKPME PPAPAIPSRY QQVPQQPHPG FTGGLSKPAL 70 80 90 100 110 120 QVGQHPTQGH LYYDYQQPLA QVPVQGGQPL QAPQMLSQHM QQMQQHQYYP PQQQQQAGQQ 130 140 150 160 170 180 RISMQEIQTQ PQQIRPSQPQ PPPQQQQPQQ LQLQQRQGSM QIPQYYQPQP MMQHLQEQQQ 190 200 210 220 230 240 QQMHLQPPSY HRDPHQYTPE QAHTVQLIPL GSMSQYYYQE PQQPYSHPLY QQSHLSQHQQ 250 260 270 280 290 300 REDSQLKTYS SDRQAQAMLS SHGDLGPPDT GMGDPASSDL TRVSSTLPHR PLLSPSGIHL 310 320 330 340 350 360 NNMGPQHQQL SPSAMWPQMH LPDGRAQPGS PESSGQPKGA FGEQFDAKNK LTCSICLKEF 370 380 390 400 410 420 KNLPALNGHM RSHGGMRASP NLKQEIPRKH QPSVPKAEEP LKTVQEKKKF RHRPEPLFIP 430 440 450 460 470 480 PPPSYNPNPA ASYSGATLYQ SQLRSPRVLG DHLLLDPTHE LPPYTPPPML SPVRQGSGLF 490 500 510 520 530 540 SNVLISGHGP GAHPQLPLTP LTPTPRVLLC RSNSIDGSNV TVTPGPGEQT VDVEPRINIG 550 560 570 580 590 600 LRFQAEIPEL QDISALAQDT HKATLVWKPW PELENHDLQQ RVENLLNLCC SSALPGGGTN 610 620 630 640 650 660 SEFALHSLFE AKGDVMVALE MLLLRKPVRL KCHPLANYHY AGSDKWTSLE RKLFNKALAT 670 680 690 700 710 720 YSKDFIFVQK MVKSKTVAQC VEYYYTWKKI MRLGRKHRTR LAEIIDDCVT SEEEEELEEE 730 740 750 760 770 780 EEEDPEEDRK STKEEESEVP KSPEPPPVPV LAPTEGPPLQ ALGQPSGSFI CEMPNCGADC 790 800 810 820 830 840 RCHVTPFLPQ VFSSRQALNG HARIHGGTNQ VTKARGAIPS GKQKPGGTQS GYCSVKSSPS 850 860 870 880 890 900 HSTTSGETDP TTIFPCKECG KVFFKIKSRN AHMKTHRQQE EQQRQKAQKA AFAAEMAATI 910 920 930 940 950 960 ERTTGPVGAP GLLPLDQLSL IKPIKDVDIL DDDVVQQLGG VMEEAEVVDT DLLLDDQDSV LLQGDAEL
	Isoform 4 [UniParc]. Checksum: F0325B9D6F297BBB	FASTA	1,117	123,601
	10 20 30 40 50 60 MGDQQLYKTN HVAHGSENLF YQQPPLGVHS GLNHNYGNAV TGGGMDAPQA SPISPHFPQD 70 80 90 100 110 120 TRDGLGLPVG SKNLGQMDTS RQGGWGSHAG PGNHVQLRGN LANSNMMWGA PAQAEPTDGY 130 140 150 160 170 180 QYTYSQASEI RTQKLTSGVL HKLDSFTQVF ANQNLRIQVN NMAQVLHTQS AVMDGAPDSA 190 200 210 220 230 240 LRQLLSQKPM EPPAPAIPSR YQQVPQQPHP GFTGGLSKPA LQVGQHPTQG HLYYDYQQPL 250 260 270 280 290 300 AQVPVQGGQP LQAPQMLSQH MQQMQQHQYY PPQQQQQAGQ QRISMQEIQT QPQQIRPSQP 310 320 330 340 350 360 QPPPQQQQPQ QLQLQQRQGS MQIPQYYQPQ PMMQHLQEQQ QQQMHLQPPS YHRDPHQYTP 370 380 390 400 410 420 EQAHTVQLIP LGSMSQYYYQ EPQQPYSHPL YQQSHLSQHQ QREDSQLKTY SSDRQAQAML 430 440 450 460 470 480 SSHGDLGPPD TGMGDPASSD LTRVSSTLPH RPLLSPSGIH LNNMGPQHQQ LSPSAMWPQM 490 500 510 520 530 540 HLPDGRAQPG SPESSGQPKG AFGEQFDAKN KLTCSICLKE FKNLPALNGH MRSHGGMRAS 550 560 570 580 590 600 PNLKQEIPRK HQPSVPKAEE PLKTVQEKKK FRHRPEPLFI PPPPSYNPNP AASYSGATLY 610 620 630 640 650 660 QSQLRSPRVL GDHLLLDPTH ELPPYTPPPM LSPVRQGSGL FSNVLISGHG PGAHPQLPLT 670 680 690 700 710 720 PLTPTPRVLL CRSNSIDGSN VTVTPGPGEQ TVDVEPRINI GLRFQAEIPE LQDISALAQD 730 740 750 760 770 780 THKATLVWKP WPELENHDLQ QRVENLLNLC CSSALPGGGT NSEFALHSLF EAKGDVMVAL 790 800 810 820 830 840 EMLLLRKPVR LKCHPLANYH YAGSDKWTSL ERKLFNKALA TYSKDFIFVQ KMVKSKTVAQ 850 860 870 880 890 900 CVEYYYTWKK IMRLGRKHRT RLAEIIDDCV TSEEEEELEE EEEEDPEEDR KSTKEEESEV 910 920 930 940 950 960 PKSPEPPPVP VLAPTEGPPL QALGQPSGSF ICEMPNCGAV FSSRQALNGH ARIHGGTNQV 970 980 990 1000 1010 1020 TKARGAIPSG KQKPGGTQSG YCSVKSSPSH STTSGETDPT TIFPCKECGK VFFKIKSRNA 1030 1040 1050 1060 1070 1080 HMKTHRQQEE QQRQKAQKAA FAAEMAATIE RTTGPVGAPG LLPLDQLSLI KPIKDVDILD 1090 1100 1110 DDVVQQLGGV MEEAEVVDTD LLLDDQDSVL LQGDAEL
	Isoform 5 [UniParc]. Checksum: BDE472412D3DFF89	FASTA	1,129	124,999
	10 20 30 40 50 60 MGDQQLYKTN HVAHGSENLF YQQPPLGVHS GLNHNYGNAV TGGGMDAPQA SPISPHFPQD 70 80 90 100 110 120 TRDGLGLPVG SKNLGQMDTS RQGGWGSHAG PGNHVQLRGN LANSNMMWGA PAQAEPTDGY 130 140 150 160 170 180 QYTYSQASEI RTQKLTSGVL HKLDSFTQVF ANQNLRIQVN NMAQVLHTQS AVMDGAPDSA 190 200 210 220 230 240 LRQLLSQKPM EPPAPAIPSR YQQVPQQPHP GFTGGLSKPA LQVGQHPTQG HLYYDYQQPL 250 260 270 280 290 300 AQVPVQGGQP LQAPQMLSQH MQQMQQHQYY PPQQQQQAGQ QRISMQEIQT QPQQIRPSQP 310 320 330 340 350 360 QPPPQQQQPQ QLQLQQRQGS MQIPQYYQPQ PMMQHLQEQQ QQQMHLQPPS YHRDPHQYTP 370 380 390 400 410 420 EQAHTVQLIP LGSMSQYYYQ EPQQPYSHPL YQQSHLSQHQ QREDSQLKTY SSDRQAQAML 430 440 450 460 470 480 SSHGDLGPPD TGMGDPASSD LTRVSSTLPH RPLLSPSGIH LNNMGPQHQQ LSPSAMWPQM 490 500 510 520 530 540 HLPDGRAQPG SPESSGQPKG AFGEQFDAKN KLTCSICLKE FKNLPALNGH MRSHGGMRAS 550 560 570 580 590 600 PNLKQEIPRK HQPSVPKAEE PLKTVQEKKK FRHRPEPLFI PPPPSYNPNP AASYSGATLY 610 620 630 640 650 660 QSQLRSPRVL GDHLLLDPTH ELPPYTPPPM LSPVRQGSGL FSNVLISGHG PGAHPQLPLT 670 680 690 700 710 720 PLTPTPRVLL CRSNSIDGSN VTVTPGPGEQ TVDVEPRINI GLRFQAEIPE LQDISALAQD 730 740 750 760 770 780 THKATLVWKP WPELENHDLQ QRVENLLNLC CSSALPGGGT NSEFALHSLF EAKGDVMVAL 790 800 810 820 830 840 EMLLLRKPVR LKCHPLANYH YAGSDKWTSL ERKLFNKALA TYSKDFIFVQ KMVKSKTVAQ 850 860 870 880 890 900 CVEYYYTWKK IMRLGRKHRT RLAEIIDDCV TSEEEEELEE EEEEDPEEDR KSTKEEESEV 910 920 930 940 950 960 PKSPEPPPVP VLAPTEGPPL QALGQPSGSF ICEMPNCGAD CRCHVTPFLP QVFSSRQALN 970 980 990 1000 1010 1020 GHARIHGGTN QVTKARGAIP SGKQKPGGTQ SGYCSVKSSP SHSTTSGETD PTTIFPCKEC 1030 1040 1050 1060 1070 1080 GKVFFKIKSR NAHMKTHRQQ EEQQRQKAQK AAFAAEMAAT IERTTGPVGA PGLLPLDQLS 1090 1100 1110 1120 LIKPIKDVDI LDDDVVQQLG GVMEEAEVVD TDLLLDDQDS VLLQGDAEL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel zinc finger protein TReP-132 interacts with CBP/p300 to regulate human CYP11A1 gene expression." Gizard F., Lavallee B., DeWitte F., Hum D.W. J. Biol. Chem. 276:33881-33892(2001) [PubMed: 11349124] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH CREBBP AND EP300. Tissue: Adrenal gland.
[2]	"The cDNA sequences of rapa-1 and -2, two zinc finger proteins with unique structural characteristics." Mauch S., Sedlacek R., Krawinkel U. Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3).
[3]	"Functional identification of genes causing estrogen independence of human breast cancer cells." van Agthoven T., Veldscholte J., Smid M., van Agthoven T.L., Vreede L., Broertjes M., de Vries I., de Jong D., Sarwari R., Dorssers L.C.J. Breast Cancer Res. Treat. 114:23-30(2009) [PubMed: 18351453] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[4]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed: 14574404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 900-1200 (ISOFORMS 1/2/4). Tissue: Placenta.
[6]	"Large-scale characterization of HeLa cell nuclear phosphoproteins." Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004) [PubMed: 15302935] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-491, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[7]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-767, MASS SPECTROMETRY. Tissue: Leukemic T-cell.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF297872 mRNA. Translation: AAL01653.1. AJ277275 mRNA. Translation: CAB88206.1. AJ277276 mRNA. Translation: CAB88207.1. AM404259 mRNA. Translation: CAL49295.1. AM404183 mRNA. Translation: CAL49297.1. AL096814 Genomic DNA. Translation: CAD92526.1. AL096814 Genomic DNA. Translation: CAD92527.2. AL096814 Genomic DNA. Translation: CAD92528.2. AK002096 mRNA. Translation: BAA92082.1. Different initiation.
IPI	IPI00044583. IPI00376357. IPI00413735. IPI00853356. IPI00853414.
RefSeq	NP_277037.1. NM_033502.2.
UniGene	Hs.485392.
3D structure databases
ProteinModelPortal	Q96PN7.
SMR	Q96PN7. Positions 889-934, 1010-1108.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96PN7. 2 interactions.
STRING	Q96PN7.
PTM databases
PhosphoSite	Q96PN7.
Polymorphism databases
DMDM	74762683.
Proteomic databases
PRIDE	Q96PN7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000372922; ENSP00000362013; ENSG00000124496.
GeneID	55809.
KEGG	hsa:55809.
UCSC	uc003osb.1. human. uc003osc.1. human. uc003osd.1. human.
Organism-specific databases
CTD	55809.
GeneCards	GC06M042192.
H-InvDB	HIX0005881.
HGNC	HGNC:18273. TRERF1.
MIM	610322. gene.
neXtProt	NX_Q96PN7.
PharmGKB	PA134923539.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG08780.
GeneTree	ENSGT00530000063277.
HOVERGEN	HBG082398.
InParanoid	Q96PN7.
OMA	QIPQYYQ.
OrthoDB	EOG4VHK5R.
PhylomeDB	Q96PN7.
Gene expression databases
ArrayExpress	Q96PN7.
Bgee	Q96PN7.
CleanEx	HS_TRERF1.
Genevestigator	Q96PN7.
GermOnline	ENSG00000124496. Homo sapiens.
Family and domain databases
InterPro	IPR000949. ELM2_dom. IPR009057. Homeodomain-like. IPR001005. SANT_DNA-bd. IPR017884. SANT_eukarya. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Gene3D	G3DSA:3.30.160.60. Znf_C2H2/integrase_DNA-bd. 2 hits.
Pfam	PF01448. ELM2. 1 hit. PF00096. zf-C2H2. 1 hit. [Graphical view]
SMART	SM00717. SANT. 1 hit. SM00355. ZnF_C2H2. 3 hits. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS51156. ELM2. 1 hit. PS51293. SANT. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 3 hits. PS50157. ZINC_FINGER_C2H2_2. 3 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	60969.
SOURCE	Search...

Entry information

Entry name

TREF1_HUMAN

Accession

Primary (citable) accession number: Q96PN7
Secondary accession number(s): Q05GC6 , Q7Z6T2, Q7Z6T3, Q9NQ72, Q9NQ73, Q9NUN9

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 13, 2005
Last sequence update:	December 1, 2001
Last modified:	January 25, 2012
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.