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Q96PN6

- ADCYA_HUMAN

UniProt

Q96PN6 - ADCYA_HUMAN

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Protein

Adenylate cyclase type 10

Gene

ADCY10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Soluble adenylyl cyclase that has a critical role in mammalian spermatogenesis. Produces the cAMP which mediates in part the cAMP-responsive nuclear factors indispensable for maturation of sperm in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization. May be the bicarbonate sensor. Involved in ciliary beat regulation.2 Publications

Catalytic activityi

ATP = 3',5'-cyclic AMP + diphosphate.

Cofactori

Binds 2 magnesium ions per subunit.By similarity

Enzyme regulationi

Activated by manganese or magnesium ions. In the presence of magnesium ions, the enzyme is activated by bicarbonate while in the presence of manganese ions, the enzyme is inhibited by bicarbonate. In the absence of magnesium and bicarbonate, the enzyme is weakly activated by calcium.1 Publication

Kineticsi

  1. KM=0.8 mM for ATP-Mn2+1 Publication
  2. KM=2.41 mM for Mg2+1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi47 – 471Magnesium 1PROSITE-ProRule annotation
Metal bindingi47 – 471Magnesium 2PROSITE-ProRule annotation
Metal bindingi48 – 481Magnesium 2; via carbonyl oxygenPROSITE-ProRule annotation
Metal bindingi99 – 991Magnesium 1PROSITE-ProRule annotation
Metal bindingi99 – 991Magnesium 2PROSITE-ProRule annotation

GO - Molecular functioni

  1. adenylate cyclase activity Source: UniProtKB
  2. ATP binding Source: UniProtKB-KW
  3. magnesium ion binding Source: InterPro
  4. manganese ion binding Source: Ensembl

GO - Biological processi

  1. cAMP biosynthetic process Source: UniProtKB
  2. intracellular signal transduction Source: InterPro
  3. positive regulation of apoptotic process Source: Ensembl
  4. spermatogenesis Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

cAMP biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylate cyclase type 10 (EC:4.6.1.1)
Alternative name(s):
AH-related protein
Adenylate cyclase homolog
Germ cell soluble adenylyl cyclase
Short name:
hsAC
Short name:
sAC
Testicular soluble adenylyl cyclase
Gene namesi
Name:ADCY10
Synonyms:SAC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:21285. ADCY10.

Subcellular locationi

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmcytoskeleton. Cytoplasmperinuclear region
Note: Distributed to subcellular compartments containing cAMP targets. Found as a plasma membrane-associated protein, protein concentrated in the perinuclear region and protein colocalized with actin or tubulin.

GO - Cellular componenti

  1. apical part of cell Source: Ensembl
  2. axon Source: Ensembl
  3. basal part of cell Source: Ensembl
  4. cytoplasm Source: ProtInc
  5. cytoskeleton Source: UniProtKB-KW
  6. cytosol Source: UniProtKB
  7. dendrite Source: Ensembl
  8. growth cone Source: Ensembl
  9. neuronal cell body Source: Ensembl
  10. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Involvement in diseasei

Hypercalciuria absorptive 2 (HCA2) [MIM:143870]: A common type of hypercalciuria, a condition characterized by excessive urinary calcium excretion. Absorptive hypercalciuria is due to gastrointestinal hyperabsorption of calcium and is a frequent cause of calcium oxalate nephrolithiasis.1 Publication
Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.

Organism-specific databases

MIMi143870. phenotype.
Orphaneti2197. Idiopathic hypercalciuria.
PharmGKBiPA162375618.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 16101610Adenylate cyclase type 10PRO_0000317101Add
BLAST

Post-translational modificationi

Cleavage may occur to generate the active 48 kDa form.

Proteomic databases

PaxDbiQ96PN6.
PRIDEiQ96PN6.

PTM databases

PhosphoSiteiQ96PN6.

Expressioni

Tissue specificityi

Weakly expressed in multiple tissues. Expressed in brain, heart, kidney, liver, lung, pancreas, peripheral blood leukocytes, placenta, skeletal muscle, stomach, thymus, airway epithelial cells, duodenum, jejunum and ileum. Very low level of expression in bone.3 Publications

Gene expression databases

BgeeiQ96PN6.
CleanExiHS_ADCY10.
ExpressionAtlasiQ96PN6. baseline and differential.
GenevestigatoriQ96PN6.

Organism-specific databases

HPAiHPA015243.
HPA017749.

Interactioni

Protein-protein interaction databases

BioGridi120921. 1 interaction.
STRINGi9606.ENSP00000356825.

Structurei

Secondary structure

1
1610
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi12 – 176
Helixi22 – 254
Beta strandi33 – 4715
Helixi49 – 524
Helixi55 – 595
Helixi61 – 633
Helixi67 – 8822
Beta strandi92 – 965
Beta strandi98 – 1069
Helixi109 – 1113
Helixi112 – 12918
Turni130 – 1323
Beta strandi135 – 1384
Beta strandi144 – 15815
Beta strandi163 – 1697
Helixi170 – 18112
Beta strandi187 – 1893
Helixi191 – 1966
Helixi199 – 2013
Beta strandi202 – 2076
Beta strandi210 – 2189
Helixi226 – 2349
Helixi243 – 2453
Helixi251 – 2544
Helixi259 – 2668
Helixi271 – 2777
Turni283 – 2864
Beta strandi288 – 30215
Helixi307 – 32721
Beta strandi331 – 3377
Beta strandi339 – 34911
Turni351 – 3533
Helixi358 – 37417
Beta strandi379 – 39820
Beta strandi401 – 4088
Helixi409 – 42012
Beta strandi424 – 4274
Helixi429 – 4357
Helixi439 – 4413
Beta strandi442 – 4443
Beta strandi460 – 4623
Beta strandi465 – 4673

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4CLFX-ray1.70A1-469[»]
4CLKX-ray2.20A1-469[»]
4CLLX-ray1.70A1-469[»]
4CLPX-ray1.90A1-469[»]
4CLSX-ray1.85A1-469[»]
4CLTX-ray1.95A1-469[»]
4CLUX-ray1.90A1-469[»]
4CLWX-ray2.15A1-469[»]
4CLYX-ray2.05A1-469[»]
4CLZX-ray1.90A1-469[»]
4CM0X-ray3.20A1-469[»]
4CM2X-ray1.80A1-469[»]
4OYAX-ray2.03A1-469[»]
4OYBX-ray1.70A1-469[»]
4OYIX-ray1.70A1-469[»]
4OYMX-ray1.70A1-469[»]
4OYOX-ray1.75A1-469[»]
4OYPX-ray2.28A1-469[»]
4OYWX-ray1.70A1-469[»]
4OYXX-ray1.89A1-469[»]
4OYZX-ray1.74A1-469[»]
4OZ2X-ray2.10A1-469[»]
4OZ3X-ray1.70A1-469[»]
4USTX-ray1.90A1-469[»]
4USUX-ray1.95A1-469[»]
4USVX-ray2.00A1-469[»]
4USWX-ray2.05A1-469[»]
ProteinModelPortaliQ96PN6.
SMRiQ96PN6. Positions 1-467.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini42 – 179138Guanylate cyclase 1PROSITE-ProRule annotationAdd
BLAST
Domaini293 – 418126Guanylate cyclase 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.PROSITE-ProRule annotation
Contains 2 guanylate cyclase domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG2114.
GeneTreeiENSGT00390000001322.
HOGENOMiHOG000060149.
HOVERGENiHBG103835.
InParanoidiQ96PN6.
KOiK11265.
OMAiTCDSVTY.
OrthoDBiEOG780RM3.
PhylomeDBiQ96PN6.
TreeFamiTF329284.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
3.30.70.1230. 2 hits.
3.40.50.300. 2 hits.
InterProiIPR001054. A/G_cyclase.
IPR016577. Adenylate_cylcase_typ10.
IPR029787. Nucleotide_cyclase.
IPR027417. P-loop_NTPase.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PfamiPF00211. Guanylate_cyc. 2 hits.
[Graphical view]
PIRSFiPIRSF011131. Soluble_adenylyl_cyclase. 1 hit.
SMARTiSM00044. CYCc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF55073. SSF55073. 2 hits.
PROSITEiPS50125. GUANYLATE_CYCLASE_2. 2 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96PN6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNTPKEEFQD WPIVRIAAHL PDLIVYGHFS PERPFMDYFD GVLMFVDISG
60 70 80 90 100
FTAMTEKFSS AMYMDRGAEQ LVEILNYHIS AIVEKVLIFG GDILKFAGDA
110 120 130 140 150
LLALWRVERK QLKNIITVVI KCSLEIHGLF ETQEWEEGLD IRVKIGLAAG
160 170 180 190 200
HISMLVFGDE THSHFLVIGQ AVDDVRLAQN MAQMNDVILS PNCWQLCDRS
210 220 230 240 250
MIEIESVPDQ RAVKVNFLKP PPNFNFDEFF TKCTTFMHYY PSGEHKNLLR
260 270 280 290 300
LACTLKPDPE LEMSLQKYVM ESILKQIDNK QLQGYLSELR PVTIVFVNLM
310 320 330 340 350
FEDQDKAEEI GPAIQDAYMH ITSVLKIFQG QINKVFMFDK GCSFLCVFGF
360 370 380 390 400
PGEKVPDELT HALECAMDIF DFCSQVHKIQ TVSIGVASGI VFCGIVGHTV
410 420 430 440 450
RHEYTVIGQK VNLAARMMMY YPGIVTCDSV TYNGSNLPAY FFKELPKKVM
460 470 480 490 500
KGVADSGPLY QYWGRTEKVM FGMACLICNR KEDYPLLGRN KEINYFMYTM
510 520 530 540 550
KKFLISNSSQ VLMYEGLPGY GKSQILMKIE YLAQGKNHRI IAISLNKISF
560 570 580 590 600
HQTFYTIQMF MANVLGLDTC KHYKERQTNL RNKVMTLLDE KFYCLLNDIF
610 620 630 640 650
HVQFPISREI SRMSTLKKQK QLEILFMKIL KLIVKEERII FIIDEAQFVD
660 670 680 690 700
STSWRFMEKL IRTLPIFIIM SLCPFVNIPC AAARAVIKNR NTTYIVIGAV
710 720 730 740 750
QPNDISNKIC LDLNVSCISK ELDSYLGEGS CGIPFYCEEL LKNLEHHEVL
760 770 780 790 800
VFQQTESEEK TNRTWNNLFK YSIKLTEKLN MVTLHSDKES EEVCHLTSGV
810 820 830 840 850
RLKNLSPPTS LKEISLIQLD SMRLSHQMLV RCAAIIGLTF TTELLFEILP
860 870 880 890 900
CWNMKMMIKT LATLVESNIF YCFRNGKELQ KALKQNDPSF EVHYRSLSLK
910 920 930 940 950
PSEGMDHGEE EQLRELENEV IECHRIRFCN PMMQKTAYEL WLKDQRKAMH
960 970 980 990 1000
LKCARFLEED AHRCDHCRGR DFIPYHHFTV NIRLNALDMD AIKKMAMSHG
1010 1020 1030 1040 1050
FKTEEKLILS NSEIPETSAF FPENRSPEEI REKILNFFDH VLTKMKTSDE
1060 1070 1080 1090 1100
DIIPLESCQC EEILEIVILP LAHHFLALGE NDKALYYFLE IASAYLIFCD
1110 1120 1130 1140 1150
NYMAYMYLNE GQKLLKTLKK DKSWSQTFES ATFYSLKGEV CFNMGQIVLA
1160 1170 1180 1190 1200
KKMLRKALKL LNRIFPYNLI SLFLHIHVEK NRHFHYVNRQ AQESPPPGKK
1210 1220 1230 1240 1250
RLAQLYRQTV CLSLLWRIYS YSYLFHCKYY AHLAVMMQMN TALETQNCFQ
1260 1270 1280 1290 1300
IIKAYLDYSL YHHLAGYKGV WFKYEVMAME HIFNLPLKGE GIEIVAYVAE
1310 1320 1330 1340 1350
TLVFNKLIMG HLDLAIELGS RALQMWALLQ NPNRHYQSLC RLSRCLLLNS
1360 1370 1380 1390 1400
RYPQLIQVLG RLWELSVTQE HIFSKAFFYF VCLDILLYSG FVYRTFEECL
1410 1420 1430 1440 1450
EFIHQYENNR ILKFHSGLLL GLYSSVAIWY ARLQEWDNFY KFSNRAKNLL
1460 1470 1480 1490 1500
PRRTMTLTYY DGISRYMEGQ VLHLQKQIKE QSENAQASGE ELLKNLENLV
1510 1520 1530 1540 1550
AQNTTGPVFC PRLYHLMAYV CILMGDGQKC GLFLNTALRL SETQGNILEK
1560 1570 1580 1590 1600
CWLNMNKESW YSTSELKEDQ WLQTILSLPS WEKIVAGRVN IQDLQKNKFL
1610
MRANTVDNHF
Length:1,610
Mass (Da):187,149
Last modified:October 5, 2010 - v3
Checksum:iE0E205747120EFE0
GO
Isoform 2 (identifier: Q96PN6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-97: MNTPKEEFQD...IFGGDILKFA → MSLSE

Note: No experimental confirmation available.

Show »
Length:1,518
Mass (Da):176,591
Checksum:iA533D2474085BF7E
GO
Isoform 3 (identifier: Q96PN6-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1099: Missing.
     1100-1103: DNYM → MLFK
     1430-1471: YARLQEWDNF...GISRYMEGQV → ECEAGVGRRL...ELKIFCQEEP
     1472-1610: Missing.

Note: No experimental confirmation available.

Show »
Length:372
Mass (Da):43,900
Checksum:iE645DCFBE8E415A6
GO
Isoform 4 (identifier: Q96PN6-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-153: Missing.

Note: No experimental confirmation available.

Show »
Length:1,457
Mass (Da):169,750
Checksum:iB148D881126ED9A7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti942 – 9421L → P in BAG64062. (PubMed:14702039)Curated
Sequence conflicti1359 – 13591L → P in AAK96045. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti234 – 2341T → M.
Corresponds to variant rs16859886 [ dbSNP | Ensembl ].
VAR_038476
Natural varianti697 – 6971I → V.3 Publications
Corresponds to variant rs2071921 [ dbSNP | Ensembl ].
VAR_038477

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 10991099Missing in isoform 3. 1 PublicationVSP_030866Add
BLAST
Alternative sequencei1 – 153153Missing in isoform 4. 1 PublicationVSP_046329Add
BLAST
Alternative sequencei1 – 9797MNTPK…ILKFA → MSLSE in isoform 2. 1 PublicationVSP_030867Add
BLAST
Alternative sequencei1100 – 11034DNYM → MLFK in isoform 3. 1 PublicationVSP_030868
Alternative sequencei1430 – 147142YARLQ…MEGQV → ECEAGVGRRLHTSRDPGMPD FRNGTTFTNFPIELKIFCQE EP in isoform 3. 1 PublicationVSP_030869Add
BLAST
Alternative sequencei1472 – 1610139Missing in isoform 3. 1 PublicationVSP_030870Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF271058 mRNA. Translation: AAF74296.1.
AF331033 mRNA. Translation: AAL57036.1.
AF176813 mRNA. Translation: AAF65931.1.
AF299350 mRNA. Translation: AAK96045.1.
AL035122 mRNA. Translation: CAA22684.1.
AK302884 mRNA. Translation: BAG64062.1.
Z97876, Z99943 Genomic DNA. Translation: CAI20073.1.
Z97876, Z99943 Genomic DNA. Translation: CAI20074.1.
Z99943, Z97876 Genomic DNA. Translation: CAI20146.1.
Z99943, Z97876 Genomic DNA. Translation: CAI20147.1.
CH471067 Genomic DNA. Translation: EAW90804.1.
CH471067 Genomic DNA. Translation: EAW90807.1.
BC117366 mRNA. Translation: AAI17367.1.
BC117372 mRNA. Translation: AAI17373.1.
CCDSiCCDS1265.1. [Q96PN6-1]
CCDS53426.1. [Q96PN6-4]
CCDS72977.1. [Q96PN6-2]
RefSeqiNP_001161221.1. NM_001167749.2. [Q96PN6-4]
NP_060887.2. NM_018417.5. [Q96PN6-1]
UniGeneiHs.320892.

Genome annotation databases

EnsembliENST00000367848; ENSP00000356822; ENSG00000143199. [Q96PN6-2]
ENST00000367851; ENSP00000356825; ENSG00000143199. [Q96PN6-1]
ENST00000545172; ENSP00000441992; ENSG00000143199. [Q96PN6-4]
GeneIDi55811.
KEGGihsa:55811.
UCSCiuc001ger.3. human. [Q96PN6-1]
uc009wvk.3. human. [Q96PN6-2]

Polymorphism databases

DMDMi308153637.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF271058 mRNA. Translation: AAF74296.1 .
AF331033 mRNA. Translation: AAL57036.1 .
AF176813 mRNA. Translation: AAF65931.1 .
AF299350 mRNA. Translation: AAK96045.1 .
AL035122 mRNA. Translation: CAA22684.1 .
AK302884 mRNA. Translation: BAG64062.1 .
Z97876 , Z99943 Genomic DNA. Translation: CAI20073.1 .
Z97876 , Z99943 Genomic DNA. Translation: CAI20074.1 .
Z99943 , Z97876 Genomic DNA. Translation: CAI20146.1 .
Z99943 , Z97876 Genomic DNA. Translation: CAI20147.1 .
CH471067 Genomic DNA. Translation: EAW90804.1 .
CH471067 Genomic DNA. Translation: EAW90807.1 .
BC117366 mRNA. Translation: AAI17367.1 .
BC117372 mRNA. Translation: AAI17373.1 .
CCDSi CCDS1265.1. [Q96PN6-1 ]
CCDS53426.1. [Q96PN6-4 ]
CCDS72977.1. [Q96PN6-2 ]
RefSeqi NP_001161221.1. NM_001167749.2. [Q96PN6-4 ]
NP_060887.2. NM_018417.5. [Q96PN6-1 ]
UniGenei Hs.320892.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4CLF X-ray 1.70 A 1-469 [» ]
4CLK X-ray 2.20 A 1-469 [» ]
4CLL X-ray 1.70 A 1-469 [» ]
4CLP X-ray 1.90 A 1-469 [» ]
4CLS X-ray 1.85 A 1-469 [» ]
4CLT X-ray 1.95 A 1-469 [» ]
4CLU X-ray 1.90 A 1-469 [» ]
4CLW X-ray 2.15 A 1-469 [» ]
4CLY X-ray 2.05 A 1-469 [» ]
4CLZ X-ray 1.90 A 1-469 [» ]
4CM0 X-ray 3.20 A 1-469 [» ]
4CM2 X-ray 1.80 A 1-469 [» ]
4OYA X-ray 2.03 A 1-469 [» ]
4OYB X-ray 1.70 A 1-469 [» ]
4OYI X-ray 1.70 A 1-469 [» ]
4OYM X-ray 1.70 A 1-469 [» ]
4OYO X-ray 1.75 A 1-469 [» ]
4OYP X-ray 2.28 A 1-469 [» ]
4OYW X-ray 1.70 A 1-469 [» ]
4OYX X-ray 1.89 A 1-469 [» ]
4OYZ X-ray 1.74 A 1-469 [» ]
4OZ2 X-ray 2.10 A 1-469 [» ]
4OZ3 X-ray 1.70 A 1-469 [» ]
4UST X-ray 1.90 A 1-469 [» ]
4USU X-ray 1.95 A 1-469 [» ]
4USV X-ray 2.00 A 1-469 [» ]
4USW X-ray 2.05 A 1-469 [» ]
ProteinModelPortali Q96PN6.
SMRi Q96PN6. Positions 1-467.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120921. 1 interaction.
STRINGi 9606.ENSP00000356825.

Chemistry

BindingDBi Q96PN6.
ChEMBLi CHEMBL5854.

PTM databases

PhosphoSitei Q96PN6.

Polymorphism databases

DMDMi 308153637.

Proteomic databases

PaxDbi Q96PN6.
PRIDEi Q96PN6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000367848 ; ENSP00000356822 ; ENSG00000143199 . [Q96PN6-2 ]
ENST00000367851 ; ENSP00000356825 ; ENSG00000143199 . [Q96PN6-1 ]
ENST00000545172 ; ENSP00000441992 ; ENSG00000143199 . [Q96PN6-4 ]
GeneIDi 55811.
KEGGi hsa:55811.
UCSCi uc001ger.3. human. [Q96PN6-1 ]
uc009wvk.3. human. [Q96PN6-2 ]

Organism-specific databases

CTDi 55811.
GeneCardsi GC01M167778.
H-InvDB HIX0200024.
HGNCi HGNC:21285. ADCY10.
HPAi HPA015243.
HPA017749.
MIMi 143870. phenotype.
605205. gene.
neXtProti NX_Q96PN6.
Orphaneti 2197. Idiopathic hypercalciuria.
PharmGKBi PA162375618.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2114.
GeneTreei ENSGT00390000001322.
HOGENOMi HOG000060149.
HOVERGENi HBG103835.
InParanoidi Q96PN6.
KOi K11265.
OMAi TCDSVTY.
OrthoDBi EOG780RM3.
PhylomeDBi Q96PN6.
TreeFami TF329284.

Miscellaneous databases

GeneWikii ADCY10.
GenomeRNAii 55811.
NextBioi 60977.
PROi Q96PN6.
SOURCEi Search...

Gene expression databases

Bgeei Q96PN6.
CleanExi HS_ADCY10.
ExpressionAtlasi Q96PN6. baseline and differential.
Genevestigatori Q96PN6.

Family and domain databases

Gene3Di 1.25.40.10. 1 hit.
3.30.70.1230. 2 hits.
3.40.50.300. 2 hits.
InterProi IPR001054. A/G_cyclase.
IPR016577. Adenylate_cylcase_typ10.
IPR029787. Nucleotide_cyclase.
IPR027417. P-loop_NTPase.
IPR011990. TPR-like_helical_dom.
[Graphical view ]
Pfami PF00211. Guanylate_cyc. 2 hits.
[Graphical view ]
PIRSFi PIRSF011131. Soluble_adenylyl_cyclase. 1 hit.
SMARTi SM00044. CYCc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
SSF55073. SSF55073. 2 hits.
PROSITEi PS50125. GUANYLATE_CYCLASE_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and functional analysis of splice variants of the germ cell soluble adenylyl cyclase."
    Jaiswal B.S., Conti M.
    J. Biol. Chem. 276:31698-31708(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT VAL-697.
  2. "Identification and characterization of a gene with base substitutions associated with the absorptive hypercalciuria phenotype and low spinal bone density."
    Reed B.Y., Gitomer W.L., Heller H.J., Hsu M.C., Lemke M., Padalino P., Pak C.Y.C.
    J. Clin. Endocrinol. Metab. 87:1476-1485(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, INVOLVEMENT IN HCA2, VARIANT VAL-697.
    Tissue: Intestine.
  3. "Kinetic properties of 'soluble' adenylyl cyclase. Synergism between calcium and bicarbonate."
    Litvin T.N., Kamenetsky M., Zarifyan A., Buck J., Levin L.R.
    J. Biol. Chem. 278:15922-15926(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), BIOPHYSICOCHEMICAL PROPERTIES, VARIANT VAL-697.
  4. "Cloning of a human testicular soluble adenylyl cyclase."
    Khole V.V., Westbrook V.A., Mandal A., Herr J.C., Visconti P.E.
    Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  5. Rhodes S.
    Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Testis.
  7. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  10. "Compartmentalization of bicarbonate-sensitive adenylyl cyclase in distinct signaling microdomains."
    Zippin J.H., Chen Y., Nahirney P., Kamenetsky M., Wuttke M.S., Fischman D.A., Levin L.R., Buck J.
    FASEB J. 17:82-84(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  11. "Cloning and characterization of the human soluble adenylyl cyclase."
    Geng W., Wang Z., Zhang J., Reed B.Y., Pak C.Y.C., Moe O.W.
    Am. J. Physiol. 288:C1305-C1316(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, ENZYME REGULATION, SUBCELLULAR LOCATION, FUNCTION.
  12. "Soluble adenylyl cyclase is localized to cilia and contributes to ciliary beat frequency regulation via production of cAMP."
    Schmid A., Sutto Z., Nlend M.-C., Horvath G., Schmid N., Buck J., Levin L.R., Conner G.E., Fregien N., Salathe M.
    J. Gen. Physiol. 130:99-109(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiADCYA_HUMAN
AccessioniPrimary (citable) accession number: Q96PN6
Secondary accession number(s): B4DZF0
, F5GWS5, O95558, Q5R329, Q5R330, Q8WXV4, Q9NNX0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 5, 2010
Last modified: October 29, 2014
This is version 108 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3