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Protein

Adenylate cyclase type 10

Gene

ADCY10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Soluble adenylyl cyclase that has a critical role in mammalian spermatogenesis. Produces the cAMP which mediates in part the cAMP-responsive nuclear factors indispensable for maturation of sperm in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization. May be the bicarbonate sensor. Involved in ciliary beat regulation.2 Publications

Catalytic activityi

ATP = 3',5'-cyclic AMP + diphosphate.

Cofactori

Mg2+By similarityNote: Binds 2 magnesium ions per subunit.By similarity

Enzyme regulationi

Activated by manganese or magnesium ions. In the presence of magnesium ions, the enzyme is activated by bicarbonate while in the presence of manganese ions, the enzyme is inhibited by bicarbonate. In the absence of magnesium and bicarbonate, the enzyme is weakly activated by calcium.1 Publication

Kineticsi

  1. KM=0.8 mM for ATP-Mn2+1 Publication
  2. KM=2.41 mM for Mg2+1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi47 – 471Magnesium 1PROSITE-ProRule annotation
    Metal bindingi47 – 471Magnesium 2PROSITE-ProRule annotation
    Metal bindingi48 – 481Magnesium 2; via carbonyl oxygenPROSITE-ProRule annotation
    Metal bindingi99 – 991Magnesium 1PROSITE-ProRule annotation
    Metal bindingi99 – 991Magnesium 2PROSITE-ProRule annotation

    GO - Molecular functioni

    • adenylate cyclase activity Source: UniProtKB
    • ATP binding Source: UniProtKB-KW
    • magnesium ion binding Source: InterPro
    • manganese ion binding Source: Ensembl

    GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    cAMP biosynthesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi4.6.1.1. 2681.
    ReactomeiREACT_268323. Hedgehog 'off' state.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Adenylate cyclase type 10 (EC:4.6.1.1)
    Alternative name(s):
    AH-related protein
    Adenylate cyclase homolog
    Germ cell soluble adenylyl cyclase
    Short name:
    hsAC
    Short name:
    sAC
    Testicular soluble adenylyl cyclase
    Gene namesi
    Name:ADCY10
    Synonyms:SAC
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640 Componenti: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:21285. ADCY10.

    Subcellular locationi

    GO - Cellular componenti

    • apical part of cell Source: Ensembl
    • axon Source: Ensembl
    • basal part of cell Source: Ensembl
    • cytoplasm Source: ProtInc
    • cytoskeleton Source: UniProtKB-SubCell
    • cytosol Source: UniProtKB
    • dendrite Source: Ensembl
    • growth cone Source: Ensembl
    • neuronal cell body Source: Ensembl
    • perinuclear region of cytoplasm Source: UniProtKB-SubCell
    • plasma membrane Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Cytoskeleton, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Hypercalciuria absorptive 2 (HCA2)1 Publication

    Disease susceptibility is associated with variations affecting the gene represented in this entry.

    Disease descriptionA common type of hypercalciuria, a condition characterized by excessive urinary calcium excretion. Absorptive hypercalciuria is due to gastrointestinal hyperabsorption of calcium and is a frequent cause of calcium oxalate nephrolithiasis.

    See also OMIM:143870

    Organism-specific databases

    MIMi143870. phenotype.
    Orphaneti2197. Idiopathic hypercalciuria.
    PharmGKBiPA162375618.

    Polymorphism and mutation databases

    BioMutaiADCY10.
    DMDMi308153637.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 16101610Adenylate cyclase type 10PRO_0000317101Add
    BLAST

    Post-translational modificationi

    Cleavage may occur to generate the active 48 kDa form.

    Proteomic databases

    PaxDbiQ96PN6.
    PRIDEiQ96PN6.

    PTM databases

    PhosphoSiteiQ96PN6.

    Expressioni

    Tissue specificityi

    Weakly expressed in multiple tissues. Expressed in brain, heart, kidney, liver, lung, pancreas, peripheral blood leukocytes, placenta, skeletal muscle, stomach, thymus, airway epithelial cells, duodenum, jejunum and ileum. Very low level of expression in bone.3 Publications

    Gene expression databases

    BgeeiQ96PN6.
    CleanExiHS_ADCY10.
    ExpressionAtlasiQ96PN6. baseline and differential.
    GenevisibleiQ96PN6. HS.

    Organism-specific databases

    HPAiHPA015243.
    HPA017749.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000356825.

    Structurei

    Secondary structure

    1
    1610
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi12 – 176Combined sources
    Helixi22 – 254Combined sources
    Beta strandi33 – 4715Combined sources
    Helixi49 – 524Combined sources
    Helixi55 – 595Combined sources
    Helixi61 – 633Combined sources
    Helixi67 – 8822Combined sources
    Beta strandi92 – 965Combined sources
    Beta strandi98 – 1069Combined sources
    Helixi109 – 1113Combined sources
    Helixi112 – 12918Combined sources
    Turni130 – 1323Combined sources
    Beta strandi135 – 1384Combined sources
    Beta strandi144 – 15815Combined sources
    Beta strandi163 – 1697Combined sources
    Helixi170 – 18112Combined sources
    Beta strandi187 – 1893Combined sources
    Helixi191 – 1966Combined sources
    Helixi199 – 2013Combined sources
    Beta strandi202 – 2076Combined sources
    Beta strandi210 – 2189Combined sources
    Helixi226 – 2349Combined sources
    Helixi243 – 2453Combined sources
    Helixi251 – 2544Combined sources
    Helixi259 – 2668Combined sources
    Helixi271 – 2777Combined sources
    Turni283 – 2864Combined sources
    Beta strandi288 – 30215Combined sources
    Helixi307 – 32721Combined sources
    Beta strandi331 – 3377Combined sources
    Beta strandi339 – 34911Combined sources
    Turni351 – 3533Combined sources
    Helixi358 – 37417Combined sources
    Beta strandi379 – 39820Combined sources
    Beta strandi401 – 4088Combined sources
    Helixi409 – 42012Combined sources
    Beta strandi424 – 4274Combined sources
    Helixi429 – 4357Combined sources
    Helixi439 – 4413Combined sources
    Beta strandi442 – 4443Combined sources
    Beta strandi460 – 4623Combined sources
    Beta strandi465 – 4673Combined sources

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4CLFX-ray1.70A1-469[»]
    4CLKX-ray2.20A1-469[»]
    4CLLX-ray1.70A1-469[»]
    4CLPX-ray1.90A1-469[»]
    4CLSX-ray1.85A1-469[»]
    4CLTX-ray1.95A1-469[»]
    4CLUX-ray1.90A1-469[»]
    4CLWX-ray2.15A1-469[»]
    4CLYX-ray2.05A1-469[»]
    4CLZX-ray1.90A1-469[»]
    4CM0X-ray3.20A1-469[»]
    4CM2X-ray1.80A1-469[»]
    4OYAX-ray2.03A1-469[»]
    4OYBX-ray1.70A1-469[»]
    4OYIX-ray1.70A1-469[»]
    4OYMX-ray1.70A1-469[»]
    4OYOX-ray1.75A1-469[»]
    4OYPX-ray2.28A1-469[»]
    4OYWX-ray1.70A1-469[»]
    4OYXX-ray1.89A1-469[»]
    4OYZX-ray1.74A1-469[»]
    4OZ2X-ray2.10A1-469[»]
    4OZ3X-ray1.70A1-469[»]
    4USTX-ray1.90A1-469[»]
    4USUX-ray1.95A1-469[»]
    4USVX-ray2.00A1-469[»]
    4USWX-ray2.05A1-469[»]
    ProteinModelPortaliQ96PN6.
    SMRiQ96PN6. Positions 1-467.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini42 – 179138Guanylate cyclase 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini293 – 418126Guanylate cyclase 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.PROSITE-ProRule annotation
    Contains 2 guanylate cyclase domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG2114.
    GeneTreeiENSGT00390000001322.
    HOGENOMiHOG000060149.
    HOVERGENiHBG103835.
    InParanoidiQ96PN6.
    KOiK11265.
    OMAiPLESCQC.
    OrthoDBiEOG780RM3.
    PhylomeDBiQ96PN6.
    TreeFamiTF329284.

    Family and domain databases

    Gene3Di1.25.40.10. 1 hit.
    3.30.70.1230. 2 hits.
    3.40.50.300. 2 hits.
    InterProiIPR001054. A/G_cyclase.
    IPR016577. Adenylate_cylcase_typ10.
    IPR029787. Nucleotide_cyclase.
    IPR027417. P-loop_NTPase.
    IPR011990. TPR-like_helical_dom.
    [Graphical view]
    PANTHERiPTHR16305:SF23. PTHR16305:SF23. 1 hit.
    PfamiPF00211. Guanylate_cyc. 2 hits.
    [Graphical view]
    PIRSFiPIRSF011131. Soluble_adenylyl_cyclase. 1 hit.
    SMARTiSM00044. CYCc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 2 hits.
    SSF55073. SSF55073. 2 hits.
    PROSITEiPS50125. GUANYLATE_CYCLASE_2. 2 hits.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

    Isoform 1 (identifier: Q96PN6-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

            10         20         30         40         50
    MNTPKEEFQD WPIVRIAAHL PDLIVYGHFS PERPFMDYFD GVLMFVDISG
    60 70 80 90 100
    FTAMTEKFSS AMYMDRGAEQ LVEILNYHIS AIVEKVLIFG GDILKFAGDA
    110 120 130 140 150
    LLALWRVERK QLKNIITVVI KCSLEIHGLF ETQEWEEGLD IRVKIGLAAG
    160 170 180 190 200
    HISMLVFGDE THSHFLVIGQ AVDDVRLAQN MAQMNDVILS PNCWQLCDRS
    210 220 230 240 250
    MIEIESVPDQ RAVKVNFLKP PPNFNFDEFF TKCTTFMHYY PSGEHKNLLR
    260 270 280 290 300
    LACTLKPDPE LEMSLQKYVM ESILKQIDNK QLQGYLSELR PVTIVFVNLM
    310 320 330 340 350
    FEDQDKAEEI GPAIQDAYMH ITSVLKIFQG QINKVFMFDK GCSFLCVFGF
    360 370 380 390 400
    PGEKVPDELT HALECAMDIF DFCSQVHKIQ TVSIGVASGI VFCGIVGHTV
    410 420 430 440 450
    RHEYTVIGQK VNLAARMMMY YPGIVTCDSV TYNGSNLPAY FFKELPKKVM
    460 470 480 490 500
    KGVADSGPLY QYWGRTEKVM FGMACLICNR KEDYPLLGRN KEINYFMYTM
    510 520 530 540 550
    KKFLISNSSQ VLMYEGLPGY GKSQILMKIE YLAQGKNHRI IAISLNKISF
    560 570 580 590 600
    HQTFYTIQMF MANVLGLDTC KHYKERQTNL RNKVMTLLDE KFYCLLNDIF
    610 620 630 640 650
    HVQFPISREI SRMSTLKKQK QLEILFMKIL KLIVKEERII FIIDEAQFVD
    660 670 680 690 700
    STSWRFMEKL IRTLPIFIIM SLCPFVNIPC AAARAVIKNR NTTYIVIGAV
    710 720 730 740 750
    QPNDISNKIC LDLNVSCISK ELDSYLGEGS CGIPFYCEEL LKNLEHHEVL
    760 770 780 790 800
    VFQQTESEEK TNRTWNNLFK YSIKLTEKLN MVTLHSDKES EEVCHLTSGV
    810 820 830 840 850
    RLKNLSPPTS LKEISLIQLD SMRLSHQMLV RCAAIIGLTF TTELLFEILP
    860 870 880 890 900
    CWNMKMMIKT LATLVESNIF YCFRNGKELQ KALKQNDPSF EVHYRSLSLK
    910 920 930 940 950
    PSEGMDHGEE EQLRELENEV IECHRIRFCN PMMQKTAYEL WLKDQRKAMH
    960 970 980 990 1000
    LKCARFLEED AHRCDHCRGR DFIPYHHFTV NIRLNALDMD AIKKMAMSHG
    1010 1020 1030 1040 1050
    FKTEEKLILS NSEIPETSAF FPENRSPEEI REKILNFFDH VLTKMKTSDE
    1060 1070 1080 1090 1100
    DIIPLESCQC EEILEIVILP LAHHFLALGE NDKALYYFLE IASAYLIFCD
    1110 1120 1130 1140 1150
    NYMAYMYLNE GQKLLKTLKK DKSWSQTFES ATFYSLKGEV CFNMGQIVLA
    1160 1170 1180 1190 1200
    KKMLRKALKL LNRIFPYNLI SLFLHIHVEK NRHFHYVNRQ AQESPPPGKK
    1210 1220 1230 1240 1250
    RLAQLYRQTV CLSLLWRIYS YSYLFHCKYY AHLAVMMQMN TALETQNCFQ
    1260 1270 1280 1290 1300
    IIKAYLDYSL YHHLAGYKGV WFKYEVMAME HIFNLPLKGE GIEIVAYVAE
    1310 1320 1330 1340 1350
    TLVFNKLIMG HLDLAIELGS RALQMWALLQ NPNRHYQSLC RLSRCLLLNS
    1360 1370 1380 1390 1400
    RYPQLIQVLG RLWELSVTQE HIFSKAFFYF VCLDILLYSG FVYRTFEECL
    1410 1420 1430 1440 1450
    EFIHQYENNR ILKFHSGLLL GLYSSVAIWY ARLQEWDNFY KFSNRAKNLL
    1460 1470 1480 1490 1500
    PRRTMTLTYY DGISRYMEGQ VLHLQKQIKE QSENAQASGE ELLKNLENLV
    1510 1520 1530 1540 1550
    AQNTTGPVFC PRLYHLMAYV CILMGDGQKC GLFLNTALRL SETQGNILEK
    1560 1570 1580 1590 1600
    CWLNMNKESW YSTSELKEDQ WLQTILSLPS WEKIVAGRVN IQDLQKNKFL
    1610
    MRANTVDNHF
    Length:1,610
    Mass (Da):187,149
    Last modified:October 5, 2010 - v3
    Checksum:iE0E205747120EFE0
    GO
    Isoform 2 (identifier: Q96PN6-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-97: MNTPKEEFQD...IFGGDILKFA → MSLSE

    Note: No experimental confirmation available.
    Show »
    Length:1,518
    Mass (Da):176,591
    Checksum:iA533D2474085BF7E
    GO
    Isoform 3 (identifier: Q96PN6-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1099: Missing.
         1100-1103: DNYM → MLFK
         1430-1471: YARLQEWDNF...GISRYMEGQV → ECEAGVGRRL...ELKIFCQEEP
         1472-1610: Missing.

    Note: No experimental confirmation available.
    Show »
    Length:372
    Mass (Da):43,900
    Checksum:iE645DCFBE8E415A6
    GO
    Isoform 4 (identifier: Q96PN6-4) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-153: Missing.

    Note: No experimental confirmation available.
    Show »
    Length:1,457
    Mass (Da):169,750
    Checksum:iB148D881126ED9A7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti942 – 9421L → P in BAG64062 (PubMed:14702039).Curated
    Sequence conflicti1359 – 13591L → P in AAK96045 (Ref. 4) Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti234 – 2341T → M.
    Corresponds to variant rs16859886 [ dbSNP | Ensembl ].
    VAR_038476
    Natural varianti697 – 6971I → V.3 Publications
    Corresponds to variant rs2071921 [ dbSNP | Ensembl ].
    VAR_038477

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 10991099Missing in isoform 3. 1 PublicationVSP_030866Add
    BLAST
    Alternative sequencei1 – 153153Missing in isoform 4. 1 PublicationVSP_046329Add
    BLAST
    Alternative sequencei1 – 9797MNTPK…ILKFA → MSLSE in isoform 2. 1 PublicationVSP_030867Add
    BLAST
    Alternative sequencei1100 – 11034DNYM → MLFK in isoform 3. 1 PublicationVSP_030868
    Alternative sequencei1430 – 147142YARLQ…MEGQV → ECEAGVGRRLHTSRDPGMPD FRNGTTFTNFPIELKIFCQE EP in isoform 3. 1 PublicationVSP_030869Add
    BLAST
    Alternative sequencei1472 – 1610139Missing in isoform 3. 1 PublicationVSP_030870Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF271058 mRNA. Translation: AAF74296.1.
    AF331033 mRNA. Translation: AAL57036.1.
    AF176813 mRNA. Translation: AAF65931.1.
    AF299350 mRNA. Translation: AAK96045.1.
    AL035122 mRNA. Translation: CAA22684.1.
    AK302884 mRNA. Translation: BAG64062.1.
    Z97876, Z99943 Genomic DNA. Translation: CAI20073.1.
    Z97876, Z99943 Genomic DNA. Translation: CAI20074.1.
    Z99943, Z97876 Genomic DNA. Translation: CAI20146.1.
    Z99943, Z97876 Genomic DNA. Translation: CAI20147.1.
    CH471067 Genomic DNA. Translation: EAW90804.1.
    CH471067 Genomic DNA. Translation: EAW90807.1.
    BC117366 mRNA. Translation: AAI17367.1.
    BC117372 mRNA. Translation: AAI17373.1.
    CCDSiCCDS1265.1. [Q96PN6-1]
    CCDS53426.1. [Q96PN6-4]
    CCDS72977.1. [Q96PN6-2]
    RefSeqiNP_001161221.1. NM_001167749.2. [Q96PN6-4]
    NP_001284701.1. NM_001297772.1. [Q96PN6-2]
    NP_060887.2. NM_018417.5. [Q96PN6-1]
    XP_011508062.1. XM_011509760.1. [Q96PN6-1]
    XP_011508067.1. XM_011509765.1. [Q96PN6-2]
    UniGeneiHs.320892.

    Genome annotation databases

    EnsembliENST00000367848; ENSP00000356822; ENSG00000143199. [Q96PN6-2]
    ENST00000367851; ENSP00000356825; ENSG00000143199.
    ENST00000545172; ENSP00000441992; ENSG00000143199. [Q96PN6-4]
    GeneIDi55811.
    KEGGihsa:55811.
    UCSCiuc001ger.3. human. [Q96PN6-1]
    uc009wvk.3. human. [Q96PN6-2]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF271058 mRNA. Translation: AAF74296.1.
    AF331033 mRNA. Translation: AAL57036.1.
    AF176813 mRNA. Translation: AAF65931.1.
    AF299350 mRNA. Translation: AAK96045.1.
    AL035122 mRNA. Translation: CAA22684.1.
    AK302884 mRNA. Translation: BAG64062.1.
    Z97876, Z99943 Genomic DNA. Translation: CAI20073.1.
    Z97876, Z99943 Genomic DNA. Translation: CAI20074.1.
    Z99943, Z97876 Genomic DNA. Translation: CAI20146.1.
    Z99943, Z97876 Genomic DNA. Translation: CAI20147.1.
    CH471067 Genomic DNA. Translation: EAW90804.1.
    CH471067 Genomic DNA. Translation: EAW90807.1.
    BC117366 mRNA. Translation: AAI17367.1.
    BC117372 mRNA. Translation: AAI17373.1.
    CCDSiCCDS1265.1. [Q96PN6-1]
    CCDS53426.1. [Q96PN6-4]
    CCDS72977.1. [Q96PN6-2]
    RefSeqiNP_001161221.1. NM_001167749.2. [Q96PN6-4]
    NP_001284701.1. NM_001297772.1. [Q96PN6-2]
    NP_060887.2. NM_018417.5. [Q96PN6-1]
    XP_011508062.1. XM_011509760.1. [Q96PN6-1]
    XP_011508067.1. XM_011509765.1. [Q96PN6-2]
    UniGeneiHs.320892.

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4CLFX-ray1.70A1-469[»]
    4CLKX-ray2.20A1-469[»]
    4CLLX-ray1.70A1-469[»]
    4CLPX-ray1.90A1-469[»]
    4CLSX-ray1.85A1-469[»]
    4CLTX-ray1.95A1-469[»]
    4CLUX-ray1.90A1-469[»]
    4CLWX-ray2.15A1-469[»]
    4CLYX-ray2.05A1-469[»]
    4CLZX-ray1.90A1-469[»]
    4CM0X-ray3.20A1-469[»]
    4CM2X-ray1.80A1-469[»]
    4OYAX-ray2.03A1-469[»]
    4OYBX-ray1.70A1-469[»]
    4OYIX-ray1.70A1-469[»]
    4OYMX-ray1.70A1-469[»]
    4OYOX-ray1.75A1-469[»]
    4OYPX-ray2.28A1-469[»]
    4OYWX-ray1.70A1-469[»]
    4OYXX-ray1.89A1-469[»]
    4OYZX-ray1.74A1-469[»]
    4OZ2X-ray2.10A1-469[»]
    4OZ3X-ray1.70A1-469[»]
    4USTX-ray1.90A1-469[»]
    4USUX-ray1.95A1-469[»]
    4USVX-ray2.00A1-469[»]
    4USWX-ray2.05A1-469[»]
    ProteinModelPortaliQ96PN6.
    SMRiQ96PN6. Positions 1-467.
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    STRINGi9606.ENSP00000356825.

    Chemistry

    BindingDBiQ96PN6.
    ChEMBLiCHEMBL5854.

    PTM databases

    PhosphoSiteiQ96PN6.

    Polymorphism and mutation databases

    BioMutaiADCY10.
    DMDMi308153637.

    Proteomic databases

    PaxDbiQ96PN6.
    PRIDEiQ96PN6.

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000367848; ENSP00000356822; ENSG00000143199. [Q96PN6-2]
    ENST00000367851; ENSP00000356825; ENSG00000143199.
    ENST00000545172; ENSP00000441992; ENSG00000143199. [Q96PN6-4]
    GeneIDi55811.
    KEGGihsa:55811.
    UCSCiuc001ger.3. human. [Q96PN6-1]
    uc009wvk.3. human. [Q96PN6-2]

    Organism-specific databases

    CTDi55811.
    GeneCardsiGC01M167778.
    H-InvDBHIX0200024.
    HGNCiHGNC:21285. ADCY10.
    HPAiHPA015243.
    HPA017749.
    MIMi143870. phenotype.
    605205. gene.
    neXtProtiNX_Q96PN6.
    Orphaneti2197. Idiopathic hypercalciuria.
    PharmGKBiPA162375618.
    GenAtlasiSearch...

    Phylogenomic databases

    eggNOGiCOG2114.
    GeneTreeiENSGT00390000001322.
    HOGENOMiHOG000060149.
    HOVERGENiHBG103835.
    InParanoidiQ96PN6.
    KOiK11265.
    OMAiPLESCQC.
    OrthoDBiEOG780RM3.
    PhylomeDBiQ96PN6.
    TreeFamiTF329284.

    Enzyme and pathway databases

    BRENDAi4.6.1.1. 2681.
    ReactomeiREACT_268323. Hedgehog 'off' state.

    Miscellaneous databases

    GeneWikiiADCY10.
    GenomeRNAii55811.
    NextBioi60977.
    PROiQ96PN6.
    SOURCEiSearch...

    Gene expression databases

    BgeeiQ96PN6.
    CleanExiHS_ADCY10.
    ExpressionAtlasiQ96PN6. baseline and differential.
    GenevisibleiQ96PN6. HS.

    Family and domain databases

    Gene3Di1.25.40.10. 1 hit.
    3.30.70.1230. 2 hits.
    3.40.50.300. 2 hits.
    InterProiIPR001054. A/G_cyclase.
    IPR016577. Adenylate_cylcase_typ10.
    IPR029787. Nucleotide_cyclase.
    IPR027417. P-loop_NTPase.
    IPR011990. TPR-like_helical_dom.
    [Graphical view]
    PANTHERiPTHR16305:SF23. PTHR16305:SF23. 1 hit.
    PfamiPF00211. Guanylate_cyc. 2 hits.
    [Graphical view]
    PIRSFiPIRSF011131. Soluble_adenylyl_cyclase. 1 hit.
    SMARTiSM00044. CYCc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 2 hits.
    SSF55073. SSF55073. 2 hits.
    PROSITEiPS50125. GUANYLATE_CYCLASE_2. 2 hits.
    [Graphical view]
    ProtoNetiSearch...

    Publicationsi

    « Hide 'large scale' publications
    1. "Identification and functional analysis of splice variants of the germ cell soluble adenylyl cyclase."
      Jaiswal B.S., Conti M.
      J. Biol. Chem. 276:31698-31708(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT VAL-697.
    2. "Identification and characterization of a gene with base substitutions associated with the absorptive hypercalciuria phenotype and low spinal bone density."
      Reed B.Y., Gitomer W.L., Heller H.J., Hsu M.C., Lemke M., Padalino P., Pak C.Y.C.
      J. Clin. Endocrinol. Metab. 87:1476-1485(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, INVOLVEMENT IN HCA2, VARIANT VAL-697.
      Tissue: Intestine.
    3. "Kinetic properties of 'soluble' adenylyl cyclase. Synergism between calcium and bicarbonate."
      Litvin T.N., Kamenetsky M., Zarifyan A., Buck J., Levin L.R.
      J. Biol. Chem. 278:15922-15926(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), BIOPHYSICOCHEMICAL PROPERTIES, VARIANT VAL-697.
    4. "Cloning of a human testicular soluble adenylyl cyclase."
      Khole V.V., Westbrook V.A., Mandal A., Herr J.C., Visconti P.E.
      Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    5. Rhodes S.
      Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
      Tissue: Testis.
    7. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    10. "Compartmentalization of bicarbonate-sensitive adenylyl cyclase in distinct signaling microdomains."
      Zippin J.H., Chen Y., Nahirney P., Kamenetsky M., Wuttke M.S., Fischman D.A., Levin L.R., Buck J.
      FASEB J. 17:82-84(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    11. "Cloning and characterization of the human soluble adenylyl cyclase."
      Geng W., Wang Z., Zhang J., Reed B.Y., Pak C.Y.C., Moe O.W.
      Am. J. Physiol. 288:C1305-C1316(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, ENZYME REGULATION, SUBCELLULAR LOCATION, FUNCTION.
    12. "Soluble adenylyl cyclase is localized to cilia and contributes to ciliary beat frequency regulation via production of cAMP."
      Schmid A., Sutto Z., Nlend M.-C., Horvath G., Schmid N., Buck J., Levin L.R., Conner G.E., Fregien N., Salathe M.
      J. Gen. Physiol. 130:99-109(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiADCYA_HUMAN
    AccessioniPrimary (citable) accession number: Q96PN6
    Secondary accession number(s): B4DZF0
    , F5GWS5, O95558, Q5R329, Q5R330, Q8WXV4, Q9NNX0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: October 5, 2010
    Last modified: July 22, 2015
    This is version 115 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

    Similar proteinsi

    Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
    100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
    90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
    50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.