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Protein

Adenylate cyclase type 10

Gene

ADCY10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the formation of the signaling molecule cAMP (PubMed:12609998, PubMed:15659711, PubMed:24616449, PubMed:25040695, PubMed:24567411). May function as sensor that mediates responses to changes in cellular bicarbonate and CO2 levels (PubMed:15659711, PubMed:17591988). Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP-responsive nuclear factors indispensable for sperm maturation in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization (By similarity). Involved in ciliary beat regulation (PubMed:17591988).By similarity5 Publications

Catalytic activityi

ATP = 3',5'-cyclic AMP + diphosphate.5 Publications

Cofactori

Mg2+1 Publication4 Publications, Mn2+3 PublicationsNote: Binds 2 magnesium ions per subunit (PubMed:25040695). Is also active with manganese (in vitro) (PubMed:12609998, PubMed:15659711, PubMed:24616449).1 Publication3 Publications

Enzyme regulationi

Activated by manganese or magnesium ions (PubMed:12609998, PubMed:24616449). In the presence of magnesium ions, the enzyme is activated by bicarbonate (PubMed:12609998, PubMed:15659711, PubMed:24567411). In the presence of manganese ions, the enzyme is inhibited by bicarbonate (PubMed:15659711). In the absence of magnesium and bicarbonate, the enzyme is weakly activated by calcium (PubMed:15659711). Calcium mildly increases the enzyme activity, also in the presence of magnesium ions (PubMed:15659711, PubMed:25040695).5 Publications

Kineticsi

  1. KM=0.8 mM for ATP-Mn2+1 Publication
  2. KM=2.41 mM for Mg2+1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Metal bindingi47Magnesium 1PROSITE-ProRule annotation2 Publications1 Publication1
    Metal bindingi47Magnesium 2PROSITE-ProRule annotation1
    Metal bindingi48Magnesium 2; via carbonyl oxygenPROSITE-ProRule annotation1
    Binding sitei95BicarbonateCombined sources2 Publications1
    Metal bindingi99Magnesium 1PROSITE-ProRule annotation2 Publications1 Publication1
    Metal bindingi99Magnesium 2PROSITE-ProRule annotation1
    Binding sitei99ATPCombined sources2 Publications1 Publication1
    Binding sitei144ATPCombined sources2 Publications1 Publication1
    Binding sitei167Bicarbonate; via amide nitrogen and carbonyl oxygenCombined sources2 Publications1
    Binding sitei176BicarbonateCombined sources2 Publications1
    Binding sitei337Bicarbonate; via amide nitrogenCombined sources2 Publications1
    Binding sitei406ATP; via carbonyl oxygenCombined sources2 Publications1 Publication1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Nucleotide bindingi47 – 52ATPCombined sources2 Publications1 Publication6
    Nucleotide bindingi412 – 416ATP3 Publications5

    GO - Molecular functioni

    • adenylate cyclase activity Source: UniProtKB
    • ATP binding Source: UniProtKB-KW
    • bicarbonate binding Source: UniProtKB
    • magnesium ion binding Source: InterPro
    • manganese ion binding Source: Ensembl

    GO - Biological processi

    • cAMP biosynthetic process Source: UniProtKB
    • cellular response to inorganic substance Source: UniProtKB
    • epithelial cilium movement Source: UniProtKB
    • intracellular signal transduction Source: InterPro
    • positive regulation of apoptotic process Source: Ensembl
    • spermatogenesis Source: InterPro
    Complete GO annotation...

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    cAMP biosynthesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciZFISH:HS07010-MONOMER.
    BRENDAi4.6.1.1. 2681.
    ReactomeiR-HSA-5610787. Hedgehog 'off' state.
    SIGNORiQ96PN6.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Adenylate cyclase type 10 (EC:4.6.1.15 Publications)
    Alternative name(s):
    AH-related protein
    Adenylate cyclase homolog
    Germ cell soluble adenylyl cyclase1 Publication
    Short name:
    hsAC
    Short name:
    sAC2 Publications
    Testicular soluble adenylyl cyclase
    Gene namesi
    Name:ADCY10
    Synonyms:SAC
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    Proteomesi
    • UP000005640 Componenti: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:21285. ADCY10.

    Subcellular locationi

    GO - Cellular componenti

    • apical part of cell Source: Ensembl
    • axon Source: Ensembl
    • basal part of cell Source: Ensembl
    • cilium Source: UniProtKB-SubCell
    • cytoplasm Source: ProtInc
    • cytoskeleton Source: UniProtKB-SubCell
    • cytosol Source: UniProtKB
    • dendrite Source: Ensembl
    • growth cone Source: Ensembl
    • mitochondrion Source: UniProtKB-SubCell
    • neuronal cell body Source: Ensembl
    • nucleus Source: UniProtKB
    • perinuclear region of cytoplasm Source: UniProtKB
    • plasma membrane Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane, Mitochondrion, Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    Hypercalciuria absorptive 2 (HCA2)1 Publication
    Disease susceptibility is associated with variations affecting the gene represented in this entry.
    Disease descriptionA common type of hypercalciuria, a condition characterized by excessive urinary calcium excretion. Absorptive hypercalciuria is due to gastrointestinal hyperabsorption of calcium and is a frequent cause of calcium oxalate nephrolithiasis.
    See also OMIM:143870

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Mutagenesisi95K → A: Nearly abolishes bicarbonate-mediated increase of enzyme activity. Abolishes bicarbonate-mediated increase of enzyme activity; when associated with A-176. 1 Publication1
    Mutagenesisi176R → A: Reduces bicarbonate-mediated increase of enzyme activity. Abolishes bicarbonate-mediated increase of enzyme activity; when associated with A-95. 1 Publication1

    Organism-specific databases

    DisGeNETi55811.
    MalaCardsiADCY10.
    MIMi143870. phenotype.
    OpenTargetsiENSG00000143199.
    Orphaneti2197. Idiopathic hypercalciuria.
    PharmGKBiPA162375618.

    Chemistry databases

    ChEMBLiCHEMBL5854.

    Polymorphism and mutation databases

    BioMutaiADCY10.
    DMDMi308153637.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00003171011 – 1610Adenylate cyclase type 10Add BLAST1610

    Post-translational modificationi

    Cleavage may occur to generate the active 48 kDa form.Curated

    Proteomic databases

    EPDiQ96PN6.
    PaxDbiQ96PN6.
    PeptideAtlasiQ96PN6.
    PRIDEiQ96PN6.

    PTM databases

    iPTMnetiQ96PN6.
    PhosphoSitePlusiQ96PN6.
    SwissPalmiQ96PN6.

    Expressioni

    Tissue specificityi

    Detected in airway epithelial cells and testis (at protein level) (PubMed:17591988). Weakly expressed in multiple tissues. Expressed in brain, heart, kidney, liver, lung, pancreas, peripheral blood leukocytes, placenta, skeletal muscle, stomach, thymus, airway epithelial cells, duodenum, jejunum and ileum. Very low level of expression in bone.3 Publications

    Gene expression databases

    BgeeiENSG00000143199.
    CleanExiHS_ADCY10.
    ExpressionAtlasiQ96PN6. baseline and differential.
    GenevisibleiQ96PN6. HS.

    Organism-specific databases

    HPAiHPA015243.
    HPA017749.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000356825.

    Chemistry databases

    BindingDBiQ96PN6.

    Structurei

    Secondary structure

    11610
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Helixi12 – 17Combined sources6
    Helixi22 – 25Combined sources4
    Beta strandi33 – 47Combined sources15
    Helixi49 – 52Combined sources4
    Helixi55 – 59Combined sources5
    Helixi61 – 63Combined sources3
    Helixi67 – 88Combined sources22
    Beta strandi92 – 96Combined sources5
    Beta strandi98 – 106Combined sources9
    Helixi109 – 111Combined sources3
    Helixi112 – 129Combined sources18
    Turni130 – 132Combined sources3
    Beta strandi135 – 138Combined sources4
    Beta strandi144 – 158Combined sources15
    Beta strandi163 – 169Combined sources7
    Helixi170 – 181Combined sources12
    Beta strandi187 – 189Combined sources3
    Helixi191 – 196Combined sources6
    Helixi199 – 201Combined sources3
    Beta strandi202 – 207Combined sources6
    Beta strandi210 – 218Combined sources9
    Helixi226 – 234Combined sources9
    Helixi243 – 245Combined sources3
    Helixi251 – 254Combined sources4
    Helixi259 – 266Combined sources8
    Helixi271 – 277Combined sources7
    Turni283 – 286Combined sources4
    Beta strandi288 – 302Combined sources15
    Helixi307 – 327Combined sources21
    Beta strandi331 – 337Combined sources7
    Beta strandi339 – 349Combined sources11
    Turni351 – 353Combined sources3
    Helixi358 – 374Combined sources17
    Beta strandi379 – 398Combined sources20
    Beta strandi401 – 408Combined sources8
    Helixi409 – 420Combined sources12
    Beta strandi424 – 427Combined sources4
    Helixi429 – 435Combined sources7
    Helixi439 – 441Combined sources3
    Beta strandi442 – 444Combined sources3
    Beta strandi460 – 462Combined sources3
    Beta strandi465 – 467Combined sources3

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    4CLFX-ray1.70A1-469[»]
    4CLKX-ray2.20A1-469[»]
    4CLLX-ray1.70A1-469[»]
    4CLPX-ray1.90A1-469[»]
    4CLSX-ray1.85A1-469[»]
    4CLTX-ray1.95A1-469[»]
    4CLUX-ray1.90A1-469[»]
    4CLWX-ray2.15A1-469[»]
    4CLYX-ray2.05A1-469[»]
    4CLZX-ray1.90A1-469[»]
    4CM0X-ray3.20A1-469[»]
    4CM2X-ray1.80A1-469[»]
    4OYAX-ray2.03A1-469[»]
    4OYBX-ray1.70A1-469[»]
    4OYIX-ray1.70A1-469[»]
    4OYMX-ray1.70A1-469[»]
    4OYOX-ray1.75A1-469[»]
    4OYPX-ray2.28A1-469[»]
    4OYWX-ray1.70A1-469[»]
    4OYXX-ray1.89A1-469[»]
    4OYZX-ray1.74A1-469[»]
    4OZ2X-ray2.10A1-469[»]
    4OZ3X-ray1.70A1-469[»]
    4USTX-ray1.90A1-469[»]
    4USUX-ray1.95A1-469[»]
    4USVX-ray2.00A1-469[»]
    4USWX-ray2.05A1-469[»]
    5D0RX-ray2.24A1-469[»]
    5IV3X-ray1.86A1-469[»]
    5IV4X-ray1.79A1-469[»]
    ProteinModelPortaliQ96PN6.
    SMRiQ96PN6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Domaini42 – 179Guanylate cyclase 1PROSITE-ProRule annotationAdd BLAST138
    Domaini293 – 418Guanylate cyclase 2PROSITE-ProRule annotationAdd BLAST126

    Domaini

    The N-terminal guanylate cyclase domains are required for enzyme activity. Fragments or isoforms containing the first 470 amino acid residues are fully active.3 Publications

    Sequence similaritiesi

    Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.PROSITE-ProRule annotation
    Contains 2 guanylate cyclase domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiENOG410IEPA. Eukaryota.
    ENOG410ZFMC. LUCA.
    GeneTreeiENSGT00390000001322.
    HOGENOMiHOG000060149.
    HOVERGENiHBG103835.
    InParanoidiQ96PN6.
    KOiK11265.
    OMAiPLESCQC.
    OrthoDBiEOG091G00BV.
    PhylomeDBiQ96PN6.
    TreeFamiTF329284.

    Family and domain databases

    Gene3Di1.25.40.10. 1 hit.
    3.30.70.1230. 2 hits.
    3.40.50.300. 2 hits.
    InterProiIPR001054. A/G_cyclase.
    IPR016577. Adenylate_cylcase_typ10.
    IPR029787. Nucleotide_cyclase.
    IPR027417. P-loop_NTPase.
    IPR011990. TPR-like_helical_dom.
    [Graphical view]
    PfamiPF00211. Guanylate_cyc. 2 hits.
    [Graphical view]
    PIRSFiPIRSF011131. Soluble_adenylyl_cyclase. 1 hit.
    SUPFAMiSSF52540. SSF52540. 2 hits.
    SSF55073. SSF55073. 2 hits.
    PROSITEiPS50125. GUANYLATE_CYCLASE_2. 2 hits.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

    Isoform 1 (identifier: Q96PN6-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

            10         20         30         40         50
    MNTPKEEFQD WPIVRIAAHL PDLIVYGHFS PERPFMDYFD GVLMFVDISG
    60 70 80 90 100
    FTAMTEKFSS AMYMDRGAEQ LVEILNYHIS AIVEKVLIFG GDILKFAGDA
    110 120 130 140 150
    LLALWRVERK QLKNIITVVI KCSLEIHGLF ETQEWEEGLD IRVKIGLAAG
    160 170 180 190 200
    HISMLVFGDE THSHFLVIGQ AVDDVRLAQN MAQMNDVILS PNCWQLCDRS
    210 220 230 240 250
    MIEIESVPDQ RAVKVNFLKP PPNFNFDEFF TKCTTFMHYY PSGEHKNLLR
    260 270 280 290 300
    LACTLKPDPE LEMSLQKYVM ESILKQIDNK QLQGYLSELR PVTIVFVNLM
    310 320 330 340 350
    FEDQDKAEEI GPAIQDAYMH ITSVLKIFQG QINKVFMFDK GCSFLCVFGF
    360 370 380 390 400
    PGEKVPDELT HALECAMDIF DFCSQVHKIQ TVSIGVASGI VFCGIVGHTV
    410 420 430 440 450
    RHEYTVIGQK VNLAARMMMY YPGIVTCDSV TYNGSNLPAY FFKELPKKVM
    460 470 480 490 500
    KGVADSGPLY QYWGRTEKVM FGMACLICNR KEDYPLLGRN KEINYFMYTM
    510 520 530 540 550
    KKFLISNSSQ VLMYEGLPGY GKSQILMKIE YLAQGKNHRI IAISLNKISF
    560 570 580 590 600
    HQTFYTIQMF MANVLGLDTC KHYKERQTNL RNKVMTLLDE KFYCLLNDIF
    610 620 630 640 650
    HVQFPISREI SRMSTLKKQK QLEILFMKIL KLIVKEERII FIIDEAQFVD
    660 670 680 690 700
    STSWRFMEKL IRTLPIFIIM SLCPFVNIPC AAARAVIKNR NTTYIVIGAV
    710 720 730 740 750
    QPNDISNKIC LDLNVSCISK ELDSYLGEGS CGIPFYCEEL LKNLEHHEVL
    760 770 780 790 800
    VFQQTESEEK TNRTWNNLFK YSIKLTEKLN MVTLHSDKES EEVCHLTSGV
    810 820 830 840 850
    RLKNLSPPTS LKEISLIQLD SMRLSHQMLV RCAAIIGLTF TTELLFEILP
    860 870 880 890 900
    CWNMKMMIKT LATLVESNIF YCFRNGKELQ KALKQNDPSF EVHYRSLSLK
    910 920 930 940 950
    PSEGMDHGEE EQLRELENEV IECHRIRFCN PMMQKTAYEL WLKDQRKAMH
    960 970 980 990 1000
    LKCARFLEED AHRCDHCRGR DFIPYHHFTV NIRLNALDMD AIKKMAMSHG
    1010 1020 1030 1040 1050
    FKTEEKLILS NSEIPETSAF FPENRSPEEI REKILNFFDH VLTKMKTSDE
    1060 1070 1080 1090 1100
    DIIPLESCQC EEILEIVILP LAHHFLALGE NDKALYYFLE IASAYLIFCD
    1110 1120 1130 1140 1150
    NYMAYMYLNE GQKLLKTLKK DKSWSQTFES ATFYSLKGEV CFNMGQIVLA
    1160 1170 1180 1190 1200
    KKMLRKALKL LNRIFPYNLI SLFLHIHVEK NRHFHYVNRQ AQESPPPGKK
    1210 1220 1230 1240 1250
    RLAQLYRQTV CLSLLWRIYS YSYLFHCKYY AHLAVMMQMN TALETQNCFQ
    1260 1270 1280 1290 1300
    IIKAYLDYSL YHHLAGYKGV WFKYEVMAME HIFNLPLKGE GIEIVAYVAE
    1310 1320 1330 1340 1350
    TLVFNKLIMG HLDLAIELGS RALQMWALLQ NPNRHYQSLC RLSRCLLLNS
    1360 1370 1380 1390 1400
    RYPQLIQVLG RLWELSVTQE HIFSKAFFYF VCLDILLYSG FVYRTFEECL
    1410 1420 1430 1440 1450
    EFIHQYENNR ILKFHSGLLL GLYSSVAIWY ARLQEWDNFY KFSNRAKNLL
    1460 1470 1480 1490 1500
    PRRTMTLTYY DGISRYMEGQ VLHLQKQIKE QSENAQASGE ELLKNLENLV
    1510 1520 1530 1540 1550
    AQNTTGPVFC PRLYHLMAYV CILMGDGQKC GLFLNTALRL SETQGNILEK
    1560 1570 1580 1590 1600
    CWLNMNKESW YSTSELKEDQ WLQTILSLPS WEKIVAGRVN IQDLQKNKFL
    1610
    MRANTVDNHF
    Length:1,610
    Mass (Da):187,149
    Last modified:October 5, 2010 - v3
    Checksum:iE0E205747120EFE0
    GO
    Isoform 2 (identifier: Q96PN6-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-97: MNTPKEEFQD...IFGGDILKFA → MSLSE

    Note: No experimental confirmation available.
    Show »
    Length:1,518
    Mass (Da):176,591
    Checksum:iA533D2474085BF7E
    GO
    Isoform 3 (identifier: Q96PN6-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1099: Missing.
         1100-1103: DNYM → MLFK
         1430-1471: YARLQEWDNF...GISRYMEGQV → ECEAGVGRRL...ELKIFCQEEP
         1472-1610: Missing.

    Note: No experimental confirmation available.
    Show »
    Length:372
    Mass (Da):43,900
    Checksum:iE645DCFBE8E415A6
    GO
    Isoform 4 (identifier: Q96PN6-4) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-153: Missing.

    Note: No experimental confirmation available.
    Show »
    Length:1,457
    Mass (Da):169,750
    Checksum:iB148D881126ED9A7
    GO

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Sequence conflicti942L → P in BAG64062 (PubMed:14702039).Curated1
    Sequence conflicti1359L → P in AAK96045 (Ref. 4) Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_038476234T → M.Corresponds to variant rs16859886dbSNPEnsembl.1
    Natural variantiVAR_038477697I → V.3 PublicationsCorresponds to variant rs2071921dbSNPEnsembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Alternative sequenceiVSP_0308661 – 1099Missing in isoform 3. 1 PublicationAdd BLAST1099
    Alternative sequenceiVSP_0463291 – 153Missing in isoform 4. 1 PublicationAdd BLAST153
    Alternative sequenceiVSP_0308671 – 97MNTPK…ILKFA → MSLSE in isoform 2. 1 PublicationAdd BLAST97
    Alternative sequenceiVSP_0308681100 – 1103DNYM → MLFK in isoform 3. 1 Publication4
    Alternative sequenceiVSP_0308691430 – 1471YARLQ…MEGQV → ECEAGVGRRLHTSRDPGMPD FRNGTTFTNFPIELKIFCQE EP in isoform 3. 1 PublicationAdd BLAST42
    Alternative sequenceiVSP_0308701472 – 1610Missing in isoform 3. 1 PublicationAdd BLAST139

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF271058 mRNA. Translation: AAF74296.1.
    AF331033 mRNA. Translation: AAL57036.1.
    AF176813 mRNA. Translation: AAF65931.1.
    AF299350 mRNA. Translation: AAK96045.1.
    AL035122 mRNA. Translation: CAA22684.1.
    AK302884 mRNA. Translation: BAG64062.1.
    Z97876, Z99943 Genomic DNA. Translation: CAI20073.1.
    Z97876, Z99943 Genomic DNA. Translation: CAI20074.1.
    Z99943, Z97876 Genomic DNA. Translation: CAI20146.1.
    Z99943, Z97876 Genomic DNA. Translation: CAI20147.1.
    CH471067 Genomic DNA. Translation: EAW90804.1.
    CH471067 Genomic DNA. Translation: EAW90807.1.
    BC117366 mRNA. Translation: AAI17367.1.
    BC117372 mRNA. Translation: AAI17373.1.
    CCDSiCCDS1265.1. [Q96PN6-1]
    CCDS53426.1. [Q96PN6-4]
    CCDS72977.1. [Q96PN6-2]
    RefSeqiNP_001161221.1. NM_001167749.2. [Q96PN6-4]
    NP_001284701.1. NM_001297772.1. [Q96PN6-2]
    NP_060887.2. NM_018417.5. [Q96PN6-1]
    XP_011508062.1. XM_011509760.2. [Q96PN6-1]
    UniGeneiHs.320892.

    Genome annotation databases

    EnsembliENST00000367848; ENSP00000356822; ENSG00000143199. [Q96PN6-2]
    ENST00000367851; ENSP00000356825; ENSG00000143199. [Q96PN6-1]
    ENST00000545172; ENSP00000441992; ENSG00000143199. [Q96PN6-4]
    GeneIDi55811.
    KEGGihsa:55811.
    UCSCiuc001ger.4. human. [Q96PN6-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF271058 mRNA. Translation: AAF74296.1.
    AF331033 mRNA. Translation: AAL57036.1.
    AF176813 mRNA. Translation: AAF65931.1.
    AF299350 mRNA. Translation: AAK96045.1.
    AL035122 mRNA. Translation: CAA22684.1.
    AK302884 mRNA. Translation: BAG64062.1.
    Z97876, Z99943 Genomic DNA. Translation: CAI20073.1.
    Z97876, Z99943 Genomic DNA. Translation: CAI20074.1.
    Z99943, Z97876 Genomic DNA. Translation: CAI20146.1.
    Z99943, Z97876 Genomic DNA. Translation: CAI20147.1.
    CH471067 Genomic DNA. Translation: EAW90804.1.
    CH471067 Genomic DNA. Translation: EAW90807.1.
    BC117366 mRNA. Translation: AAI17367.1.
    BC117372 mRNA. Translation: AAI17373.1.
    CCDSiCCDS1265.1. [Q96PN6-1]
    CCDS53426.1. [Q96PN6-4]
    CCDS72977.1. [Q96PN6-2]
    RefSeqiNP_001161221.1. NM_001167749.2. [Q96PN6-4]
    NP_001284701.1. NM_001297772.1. [Q96PN6-2]
    NP_060887.2. NM_018417.5. [Q96PN6-1]
    XP_011508062.1. XM_011509760.2. [Q96PN6-1]
    UniGeneiHs.320892.

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    4CLFX-ray1.70A1-469[»]
    4CLKX-ray2.20A1-469[»]
    4CLLX-ray1.70A1-469[»]
    4CLPX-ray1.90A1-469[»]
    4CLSX-ray1.85A1-469[»]
    4CLTX-ray1.95A1-469[»]
    4CLUX-ray1.90A1-469[»]
    4CLWX-ray2.15A1-469[»]
    4CLYX-ray2.05A1-469[»]
    4CLZX-ray1.90A1-469[»]
    4CM0X-ray3.20A1-469[»]
    4CM2X-ray1.80A1-469[»]
    4OYAX-ray2.03A1-469[»]
    4OYBX-ray1.70A1-469[»]
    4OYIX-ray1.70A1-469[»]
    4OYMX-ray1.70A1-469[»]
    4OYOX-ray1.75A1-469[»]
    4OYPX-ray2.28A1-469[»]
    4OYWX-ray1.70A1-469[»]
    4OYXX-ray1.89A1-469[»]
    4OYZX-ray1.74A1-469[»]
    4OZ2X-ray2.10A1-469[»]
    4OZ3X-ray1.70A1-469[»]
    4USTX-ray1.90A1-469[»]
    4USUX-ray1.95A1-469[»]
    4USVX-ray2.00A1-469[»]
    4USWX-ray2.05A1-469[»]
    5D0RX-ray2.24A1-469[»]
    5IV3X-ray1.86A1-469[»]
    5IV4X-ray1.79A1-469[»]
    ProteinModelPortaliQ96PN6.
    SMRiQ96PN6.
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    STRINGi9606.ENSP00000356825.

    Chemistry databases

    BindingDBiQ96PN6.
    ChEMBLiCHEMBL5854.

    PTM databases

    iPTMnetiQ96PN6.
    PhosphoSitePlusiQ96PN6.
    SwissPalmiQ96PN6.

    Polymorphism and mutation databases

    BioMutaiADCY10.
    DMDMi308153637.

    Proteomic databases

    EPDiQ96PN6.
    PaxDbiQ96PN6.
    PeptideAtlasiQ96PN6.
    PRIDEiQ96PN6.

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000367848; ENSP00000356822; ENSG00000143199. [Q96PN6-2]
    ENST00000367851; ENSP00000356825; ENSG00000143199. [Q96PN6-1]
    ENST00000545172; ENSP00000441992; ENSG00000143199. [Q96PN6-4]
    GeneIDi55811.
    KEGGihsa:55811.
    UCSCiuc001ger.4. human. [Q96PN6-1]

    Organism-specific databases

    CTDi55811.
    DisGeNETi55811.
    GeneCardsiADCY10.
    H-InvDBHIX0200024.
    HGNCiHGNC:21285. ADCY10.
    HPAiHPA015243.
    HPA017749.
    MalaCardsiADCY10.
    MIMi143870. phenotype.
    605205. gene.
    neXtProtiNX_Q96PN6.
    OpenTargetsiENSG00000143199.
    Orphaneti2197. Idiopathic hypercalciuria.
    PharmGKBiPA162375618.
    GenAtlasiSearch...

    Phylogenomic databases

    eggNOGiENOG410IEPA. Eukaryota.
    ENOG410ZFMC. LUCA.
    GeneTreeiENSGT00390000001322.
    HOGENOMiHOG000060149.
    HOVERGENiHBG103835.
    InParanoidiQ96PN6.
    KOiK11265.
    OMAiPLESCQC.
    OrthoDBiEOG091G00BV.
    PhylomeDBiQ96PN6.
    TreeFamiTF329284.

    Enzyme and pathway databases

    BioCyciZFISH:HS07010-MONOMER.
    BRENDAi4.6.1.1. 2681.
    ReactomeiR-HSA-5610787. Hedgehog 'off' state.
    SIGNORiQ96PN6.

    Miscellaneous databases

    GeneWikiiADCY10.
    GenomeRNAii55811.
    PROiQ96PN6.
    SOURCEiSearch...

    Gene expression databases

    BgeeiENSG00000143199.
    CleanExiHS_ADCY10.
    ExpressionAtlasiQ96PN6. baseline and differential.
    GenevisibleiQ96PN6. HS.

    Family and domain databases

    Gene3Di1.25.40.10. 1 hit.
    3.30.70.1230. 2 hits.
    3.40.50.300. 2 hits.
    InterProiIPR001054. A/G_cyclase.
    IPR016577. Adenylate_cylcase_typ10.
    IPR029787. Nucleotide_cyclase.
    IPR027417. P-loop_NTPase.
    IPR011990. TPR-like_helical_dom.
    [Graphical view]
    PfamiPF00211. Guanylate_cyc. 2 hits.
    [Graphical view]
    PIRSFiPIRSF011131. Soluble_adenylyl_cyclase. 1 hit.
    SUPFAMiSSF52540. SSF52540. 2 hits.
    SSF55073. SSF55073. 2 hits.
    PROSITEiPS50125. GUANYLATE_CYCLASE_2. 2 hits.
    [Graphical view]
    ProtoNetiSearch...

    Entry informationi

    Entry nameiADCYA_HUMAN
    AccessioniPrimary (citable) accession number: Q96PN6
    Secondary accession number(s): B4DZF0
    , F5GWS5, O95558, Q5R329, Q5R330, Q8WXV4, Q9NNX0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: October 5, 2010
    Last modified: November 2, 2016
    This is version 128 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    Similar proteinsi

    Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
    100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
    90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
    50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.