Q96PN6 (ADCYA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adenylate cyclase type 10
EC=4.6.1.1

Alternative name(s):
AH-related protein
Adenylate cyclase homolog
Germ cell soluble adenylyl cyclase
Short name=hsAC
Short name=sAC
Testicular soluble adenylyl cyclase

Gene names

Name:	ADCY10
Synonyms:	SAC

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1610 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Soluble adenylyl cyclase that has a critical role in mammalian spermatogenesis. Produces the cAMP which mediates in part the cAMP-responsive nuclear factors indispensable for maturation of sperm in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization. May be the bicarbonate sensor. Involved in ciliary beat regulation. Ref.11 Ref.12
Catalytic activity	ATP = 3',5'-cyclic AMP + diphosphate.
Cofactor	Binds 2 magnesium ions per subunit By similarity.
Enzyme regulation	Activated by manganese or magnesium ions. In the presence of magnesium ions, the enzyme is activated by bicarbonate while in the presence of manganese ions, the enzyme is inhibited by bicarbonate. In the absence of magnesium and bicarbonate, the enzyme is weakly activated by calcium. Ref.11
Subcellular location	Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm › cytoskeleton. Cytoplasm › perinuclear region. Note: Distributed to subcellular compartments containing cAMP targets. Found as a plasma membrane-associated protein, protein concentrated in the perinuclear region and protein colocalized with actin or tubulin. Ref.10 Ref.11
Tissue specificity	Weakly expressed in multiple tissues. Expressed in brain, heart, kidney, liver, lung, pancreas, peripheral blood leukocytes, placenta, skeletal muscle, stomach, thymus, airway epithelial cells, duodenum, jejunum and ileum. Very low level of expression in bone. Ref.2 Ref.11 Ref.12
Post-translational modification	Cleavage may occur to generate the active 48 kDa form.
Involvement in disease	Hypercalciuria absorptive 2 (HCA2) [MIM:143870]: A common type of hypercalciuria, a condition characterized by excessive urinary calcium excretion. Absorptive hypercalciuria is due to gastrointestinal hyperabsorption of calcium and is a frequent cause of calcium oxalate nephrolithiasis. Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Ref.2
Sequence similarities	Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. Contains 2 guanylate cyclase domains.
Biophysicochemical properties	Kinetic parameters: KM=0.8 mM for ATP-Mn2+ Ref.3 KM=2.41 mM for Mg2+

Ontologies

Keywords
Biological process	cAMP biosynthesis
Cellular component	Cell membrane Cytoplasm Cytoskeleton Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	intracellular signal transduction Inferred from electronic annotation. Source: InterPro positive regulation of apoptotic process Inferred from electronic annotation. Source: Compara spermatogenesis Inferred from electronic annotation. Source: InterPro
Cellular_component	apical part of cell Inferred from electronic annotation. Source: Compara axon Inferred from electronic annotation. Source: Compara basal part of cell Inferred from electronic annotation. Source: Compara cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell cytosol Non-traceable author statement PubMed 9874775. Source: UniProtKB dendrite Inferred from electronic annotation. Source: Compara growth cone Inferred from electronic annotation. Source: Compara neuronal cell body Inferred from electronic annotation. Source: Compara perinuclear region of cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW adenylate cyclase activity Non-traceable author statement PubMed 9874775. Source: UniProtKB magnesium ion binding Inferred from electronic annotation. Source: InterPro manganese ion binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96PN6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96PN6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-97: MNTPKEEFQD...IFGGDILKFA → MSLSE

Note: No experimental confirmation available.

Isoform 3 (identifier: Q96PN6-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1099: Missing.
     1100-1103: DNYM → MLFK
     1430-1471: YARLQEWDNF...GISRYMEGQV → ECEAGVGRRL...ELKIFCQEEP
     1472-1610: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q96PN6-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-153: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1610	1610	Adenylate cyclase type 10		PRO_0000317101
Regions
	Domain	42 – 179	138	Guanylate cyclase 1
	Domain	293 – 418	126	Guanylate cyclase 2
Sites
	Metal binding	47	1	Magnesium 1 By similarity
	Metal binding	47	1	Magnesium 2 By similarity
	Metal binding	48	1	Magnesium 2; via carbonyl oxygen By similarity
	Metal binding	99	1	Magnesium 1 By similarity
	Metal binding	99	1	Magnesium 2 By similarity
Natural variations
	Alternative sequence	1 – 1099	1099	Missing in isoform 3.		VSP_030866
	Alternative sequence	1 – 153	153	Missing in isoform 4.		VSP_046329
	Alternative sequence	1 – 97	97	MNTPK…ILKFA → MSLSE in isoform 2.		VSP_030867
	Alternative sequence	1100 – 1103	4	DNYM → MLFK in isoform 3.		VSP_030868
	Alternative sequence	1430 – 1471	42	YARLQ…MEGQV → ECEAGVGRRLHTSRDPGMPD FRNGTTFTNFPIELKIFCQE EP in isoform 3.		VSP_030869
	Alternative sequence	1472 – 1610	139	Missing in isoform 3.		VSP_030870
	Natural variant	234	1	T → M. Corresponds to variant rs16859886 [ dbSNP | Ensembl ].		VAR_038476
	Natural variant	697	1	I → V. Ref.1 Ref.2 Ref.3 Corresponds to variant rs2071921 [ dbSNP | Ensembl ].		VAR_038477
Experimental info
	Sequence conflict	942	1	L → P in BAG64062. Ref.6
	Sequence conflict	1359	1	L → P in AAK96045. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 5, 2010. Version 3. Checksum: E0E205747120EFE0	FASTA	1,610	187,149
	10 20 30 40 50 60 MNTPKEEFQD WPIVRIAAHL PDLIVYGHFS PERPFMDYFD GVLMFVDISG FTAMTEKFSS 70 80 90 100 110 120 AMYMDRGAEQ LVEILNYHIS AIVEKVLIFG GDILKFAGDA LLALWRVERK QLKNIITVVI 130 140 150 160 170 180 KCSLEIHGLF ETQEWEEGLD IRVKIGLAAG HISMLVFGDE THSHFLVIGQ AVDDVRLAQN 190 200 210 220 230 240 MAQMNDVILS PNCWQLCDRS MIEIESVPDQ RAVKVNFLKP PPNFNFDEFF TKCTTFMHYY 250 260 270 280 290 300 PSGEHKNLLR LACTLKPDPE LEMSLQKYVM ESILKQIDNK QLQGYLSELR PVTIVFVNLM 310 320 330 340 350 360 FEDQDKAEEI GPAIQDAYMH ITSVLKIFQG QINKVFMFDK GCSFLCVFGF PGEKVPDELT 370 380 390 400 410 420 HALECAMDIF DFCSQVHKIQ TVSIGVASGI VFCGIVGHTV RHEYTVIGQK VNLAARMMMY 430 440 450 460 470 480 YPGIVTCDSV TYNGSNLPAY FFKELPKKVM KGVADSGPLY QYWGRTEKVM FGMACLICNR 490 500 510 520 530 540 KEDYPLLGRN KEINYFMYTM KKFLISNSSQ VLMYEGLPGY GKSQILMKIE YLAQGKNHRI 550 560 570 580 590 600 IAISLNKISF HQTFYTIQMF MANVLGLDTC KHYKERQTNL RNKVMTLLDE KFYCLLNDIF 610 620 630 640 650 660 HVQFPISREI SRMSTLKKQK QLEILFMKIL KLIVKEERII FIIDEAQFVD STSWRFMEKL 670 680 690 700 710 720 IRTLPIFIIM SLCPFVNIPC AAARAVIKNR NTTYIVIGAV QPNDISNKIC LDLNVSCISK 730 740 750 760 770 780 ELDSYLGEGS CGIPFYCEEL LKNLEHHEVL VFQQTESEEK TNRTWNNLFK YSIKLTEKLN 790 800 810 820 830 840 MVTLHSDKES EEVCHLTSGV RLKNLSPPTS LKEISLIQLD SMRLSHQMLV RCAAIIGLTF 850 860 870 880 890 900 TTELLFEILP CWNMKMMIKT LATLVESNIF YCFRNGKELQ KALKQNDPSF EVHYRSLSLK 910 920 930 940 950 960 PSEGMDHGEE EQLRELENEV IECHRIRFCN PMMQKTAYEL WLKDQRKAMH LKCARFLEED 970 980 990 1000 1010 1020 AHRCDHCRGR DFIPYHHFTV NIRLNALDMD AIKKMAMSHG FKTEEKLILS NSEIPETSAF 1030 1040 1050 1060 1070 1080 FPENRSPEEI REKILNFFDH VLTKMKTSDE DIIPLESCQC EEILEIVILP LAHHFLALGE 1090 1100 1110 1120 1130 1140 NDKALYYFLE IASAYLIFCD NYMAYMYLNE GQKLLKTLKK DKSWSQTFES ATFYSLKGEV 1150 1160 1170 1180 1190 1200 CFNMGQIVLA KKMLRKALKL LNRIFPYNLI SLFLHIHVEK NRHFHYVNRQ AQESPPPGKK 1210 1220 1230 1240 1250 1260 RLAQLYRQTV CLSLLWRIYS YSYLFHCKYY AHLAVMMQMN TALETQNCFQ IIKAYLDYSL 1270 1280 1290 1300 1310 1320 YHHLAGYKGV WFKYEVMAME HIFNLPLKGE GIEIVAYVAE TLVFNKLIMG HLDLAIELGS 1330 1340 1350 1360 1370 1380 RALQMWALLQ NPNRHYQSLC RLSRCLLLNS RYPQLIQVLG RLWELSVTQE HIFSKAFFYF 1390 1400 1410 1420 1430 1440 VCLDILLYSG FVYRTFEECL EFIHQYENNR ILKFHSGLLL GLYSSVAIWY ARLQEWDNFY 1450 1460 1470 1480 1490 1500 KFSNRAKNLL PRRTMTLTYY DGISRYMEGQ VLHLQKQIKE QSENAQASGE ELLKNLENLV 1510 1520 1530 1540 1550 1560 AQNTTGPVFC PRLYHLMAYV CILMGDGQKC GLFLNTALRL SETQGNILEK CWLNMNKESW 1570 1580 1590 1600 1610 YSTSELKEDQ WLQTILSLPS WEKIVAGRVN IQDLQKNKFL MRANTVDNHF
	Isoform 2 [UniParc]. Checksum: A533D2474085BF7E	FASTA	1,518	176,591
	10 20 30 40 50 60 MSLSEGDALL ALWRVERKQL KNIITVVIKC SLEIHGLFET QEWEEGLDIR VKIGLAAGHI 70 80 90 100 110 120 SMLVFGDETH SHFLVIGQAV DDVRLAQNMA QMNDVILSPN CWQLCDRSMI EIESVPDQRA 130 140 150 160 170 180 VKVNFLKPPP NFNFDEFFTK CTTFMHYYPS GEHKNLLRLA CTLKPDPELE MSLQKYVMES 190 200 210 220 230 240 ILKQIDNKQL QGYLSELRPV TIVFVNLMFE DQDKAEEIGP AIQDAYMHIT SVLKIFQGQI 250 260 270 280 290 300 NKVFMFDKGC SFLCVFGFPG EKVPDELTHA LECAMDIFDF CSQVHKIQTV SIGVASGIVF 310 320 330 340 350 360 CGIVGHTVRH EYTVIGQKVN LAARMMMYYP GIVTCDSVTY NGSNLPAYFF KELPKKVMKG 370 380 390 400 410 420 VADSGPLYQY WGRTEKVMFG MACLICNRKE DYPLLGRNKE INYFMYTMKK FLISNSSQVL 430 440 450 460 470 480 MYEGLPGYGK SQILMKIEYL AQGKNHRIIA ISLNKISFHQ TFYTIQMFMA NVLGLDTCKH 490 500 510 520 530 540 YKERQTNLRN KVMTLLDEKF YCLLNDIFHV QFPISREISR MSTLKKQKQL EILFMKILKL 550 560 570 580 590 600 IVKEERIIFI IDEAQFVDST SWRFMEKLIR TLPIFIIMSL CPFVNIPCAA ARAVIKNRNT 610 620 630 640 650 660 TYIVIGAVQP NDISNKICLD LNVSCISKEL DSYLGEGSCG IPFYCEELLK NLEHHEVLVF 670 680 690 700 710 720 QQTESEEKTN RTWNNLFKYS IKLTEKLNMV TLHSDKESEE VCHLTSGVRL KNLSPPTSLK 730 740 750 760 770 780 EISLIQLDSM RLSHQMLVRC AAIIGLTFTT ELLFEILPCW NMKMMIKTLA TLVESNIFYC 790 800 810 820 830 840 FRNGKELQKA LKQNDPSFEV HYRSLSLKPS EGMDHGEEEQ LRELENEVIE CHRIRFCNPM 850 860 870 880 890 900 MQKTAYELWL KDQRKAMHLK CARFLEEDAH RCDHCRGRDF IPYHHFTVNI RLNALDMDAI 910 920 930 940 950 960 KKMAMSHGFK TEEKLILSNS EIPETSAFFP ENRSPEEIRE KILNFFDHVL TKMKTSDEDI 970 980 990 1000 1010 1020 IPLESCQCEE ILEIVILPLA HHFLALGEND KALYYFLEIA SAYLIFCDNY MAYMYLNEGQ 1030 1040 1050 1060 1070 1080 KLLKTLKKDK SWSQTFESAT FYSLKGEVCF NMGQIVLAKK MLRKALKLLN RIFPYNLISL 1090 1100 1110 1120 1130 1140 FLHIHVEKNR HFHYVNRQAQ ESPPPGKKRL AQLYRQTVCL SLLWRIYSYS YLFHCKYYAH 1150 1160 1170 1180 1190 1200 LAVMMQMNTA LETQNCFQII KAYLDYSLYH HLAGYKGVWF KYEVMAMEHI FNLPLKGEGI 1210 1220 1230 1240 1250 1260 EIVAYVAETL VFNKLIMGHL DLAIELGSRA LQMWALLQNP NRHYQSLCRL SRCLLLNSRY 1270 1280 1290 1300 1310 1320 PQLIQVLGRL WELSVTQEHI FSKAFFYFVC LDILLYSGFV YRTFEECLEF IHQYENNRIL 1330 1340 1350 1360 1370 1380 KFHSGLLLGL YSSVAIWYAR LQEWDNFYKF SNRAKNLLPR RTMTLTYYDG ISRYMEGQVL 1390 1400 1410 1420 1430 1440 HLQKQIKEQS ENAQASGEEL LKNLENLVAQ NTTGPVFCPR LYHLMAYVCI LMGDGQKCGL 1450 1460 1470 1480 1490 1500 FLNTALRLSE TQGNILEKCW LNMNKESWYS TSELKEDQWL QTILSLPSWE KIVAGRVNIQ 1510 DLQKNKFLMR ANTVDNHF
	Isoform 3 [UniParc]. Checksum: E645DCFBE8E415A6	FASTA	372	43,900
	10 20 30 40 50 60 MLFKAYMYLN EGQKLLKTLK KDKSWSQTFE SATFYSLKGE VCFNMGQIVL AKKMLRKALK 70 80 90 100 110 120 LLNRIFPYNL ISLFLHIHVE KNRHFHYVNR QAQESPPPGK KRLAQLYRQT VCLSLLWRIY 130 140 150 160 170 180 SYSYLFHCKY YAHLAVMMQM NTALETQNCF QIIKAYLDYS LYHHLAGYKG VWFKYEVMAM 190 200 210 220 230 240 EHIFNLPLKG EGIEIVAYVA ETLVFNKLIM GHLDLAIELG SRALQMWALL QNPNRHYQSL 250 260 270 280 290 300 CRLSRCLLLN SRYPQLIQVL GRLWELSVTQ EHIFSKAFFY FVCLDILLYS GFVYRTFEEC 310 320 330 340 350 360 LEFIHQYENN RILKFHSGLL LGLYSSVAIW ECEAGVGRRL HTSRDPGMPD FRNGTTFTNF 370 PIELKIFCQE EP
	Isoform 4 [UniParc]. Checksum: B148D881126ED9A7	FASTA	1,457	169,750
	10 20 30 40 50 60 MLVFGDETHS HFLVIGQAVD DVRLAQNMAQ MNDVILSPNC WQLCDRSMIE IESVPDQRAV 70 80 90 100 110 120 KVNFLKPPPN FNFDEFFTKC TTFMHYYPSG EHKNLLRLAC TLKPDPELEM SLQKYVMESI 130 140 150 160 170 180 LKQIDNKQLQ GYLSELRPVT IVFVNLMFED QDKAEEIGPA IQDAYMHITS VLKIFQGQIN 190 200 210 220 230 240 KVFMFDKGCS FLCVFGFPGE KVPDELTHAL ECAMDIFDFC SQVHKIQTVS IGVASGIVFC 250 260 270 280 290 300 GIVGHTVRHE YTVIGQKVNL AARMMMYYPG IVTCDSVTYN GSNLPAYFFK ELPKKVMKGV 310 320 330 340 350 360 ADSGPLYQYW GRTEKVMFGM ACLICNRKED YPLLGRNKEI NYFMYTMKKF LISNSSQVLM 370 380 390 400 410 420 YEGLPGYGKS QILMKIEYLA QGKNHRIIAI SLNKISFHQT FYTIQMFMAN VLGLDTCKHY 430 440 450 460 470 480 KERQTNLRNK VMTLLDEKFY CLLNDIFHVQ FPISREISRM STLKKQKQLE ILFMKILKLI 490 500 510 520 530 540 VKEERIIFII DEAQFVDSTS WRFMEKLIRT LPIFIIMSLC PFVNIPCAAA RAVIKNRNTT 550 560 570 580 590 600 YIVIGAVQPN DISNKICLDL NVSCISKELD SYLGEGSCGI PFYCEELLKN LEHHEVLVFQ 610 620 630 640 650 660 QTESEEKTNR TWNNLFKYSI KLTEKLNMVT LHSDKESEEV CHLTSGVRLK NLSPPTSLKE 670 680 690 700 710 720 ISLIQLDSMR LSHQMLVRCA AIIGLTFTTE LLFEILPCWN MKMMIKTLAT LVESNIFYCF 730 740 750 760 770 780 RNGKELQKAL KQNDPSFEVH YRSLSLKPSE GMDHGEEEQL RELENEVIEC HRIRFCNPMM 790 800 810 820 830 840 QKTAYELWLK DQRKAMHLKC ARFLEEDAHR CDHCRGRDFI PYHHFTVNIR LNALDMDAIK 850 860 870 880 890 900 KMAMSHGFKT EEKLILSNSE IPETSAFFPE NRSPEEIREK ILNFFDHVLT KMKTSDEDII 910 920 930 940 950 960 PLESCQCEEI LEIVILPLAH HFLALGENDK ALYYFLEIAS AYLIFCDNYM AYMYLNEGQK 970 980 990 1000 1010 1020 LLKTLKKDKS WSQTFESATF YSLKGEVCFN MGQIVLAKKM LRKALKLLNR IFPYNLISLF 1030 1040 1050 1060 1070 1080 LHIHVEKNRH FHYVNRQAQE SPPPGKKRLA QLYRQTVCLS LLWRIYSYSY LFHCKYYAHL 1090 1100 1110 1120 1130 1140 AVMMQMNTAL ETQNCFQIIK AYLDYSLYHH LAGYKGVWFK YEVMAMEHIF NLPLKGEGIE 1150 1160 1170 1180 1190 1200 IVAYVAETLV FNKLIMGHLD LAIELGSRAL QMWALLQNPN RHYQSLCRLS RCLLLNSRYP 1210 1220 1230 1240 1250 1260 QLIQVLGRLW ELSVTQEHIF SKAFFYFVCL DILLYSGFVY RTFEECLEFI HQYENNRILK 1270 1280 1290 1300 1310 1320 FHSGLLLGLY SSVAIWYARL QEWDNFYKFS NRAKNLLPRR TMTLTYYDGI SRYMEGQVLH 1330 1340 1350 1360 1370 1380 LQKQIKEQSE NAQASGEELL KNLENLVAQN TTGPVFCPRL YHLMAYVCIL MGDGQKCGLF 1390 1400 1410 1420 1430 1440 LNTALRLSET QGNILEKCWL NMNKESWYST SELKEDQWLQ TILSLPSWEK IVAGRVNIQD 1450 LQKNKFLMRA NTVDNHF

References

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[1]	"Identification and functional analysis of splice variants of the germ cell soluble adenylyl cyclase." Jaiswal B.S., Conti M. J. Biol. Chem. 276:31698-31708(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT VAL-697.
[2]	"Identification and characterization of a gene with base substitutions associated with the absorptive hypercalciuria phenotype and low spinal bone density." Reed B.Y., Gitomer W.L., Heller H.J., Hsu M.C., Lemke M., Padalino P., Pak C.Y.C. J. Clin. Endocrinol. Metab. 87:1476-1485(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, INVOLVEMENT IN HCA2, VARIANT VAL-697. Tissue: Intestine.
[3]	"Kinetic properties of 'soluble' adenylyl cyclase. Synergism between calcium and bicarbonate." Litvin T.N., Kamenetsky M., Zarifyan A., Buck J., Levin L.R. J. Biol. Chem. 278:15922-15926(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), BIOPHYSICOCHEMICAL PROPERTIES, VARIANT VAL-697.
[4]	"Cloning of a human testicular soluble adenylyl cyclase." Khole V.V., Westbrook V.A., Mandal A., Herr J.C., Visconti P.E. Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[5]	Rhodes S. Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
[6]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Testis.
[7]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[10]	"Compartmentalization of bicarbonate-sensitive adenylyl cyclase in distinct signaling microdomains." Zippin J.H., Chen Y., Nahirney P., Kamenetsky M., Wuttke M.S., Fischman D.A., Levin L.R., Buck J. FASEB J. 17:82-84(2003) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION.
[11]	"Cloning and characterization of the human soluble adenylyl cyclase." Geng W., Wang Z., Zhang J., Reed B.Y., Pak C.Y.C., Moe O.W. Am. J. Physiol. 288:C1305-C1316(2005) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, ENZYME REGULATION, SUBCELLULAR LOCATION, FUNCTION.
[12]	"Soluble adenylyl cyclase is localized to cilia and contributes to ciliary beat frequency regulation via production of cAMP." Schmid A., Sutto Z., Nlend M.-C., Horvath G., Schmid N., Buck J., Levin L.R., Conner G.E., Fregien N., Salathe M. J. Gen. Physiol. 130:99-109(2007) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF271058 mRNA. Translation: AAF74296.1. AF331033 mRNA. Translation: AAL57036.1. AF176813 mRNA. Translation: AAF65931.1. AF299350 mRNA. Translation: AAK96045.1. AL035122 mRNA. Translation: CAA22684.1. AK302884 mRNA. Translation: BAG64062.1. Z97876, Z99943 Genomic DNA. Translation: CAI20073.1. Z97876, Z99943 Genomic DNA. Translation: CAI20074.1. Z99943, Z97876 Genomic DNA. Translation: CAI20146.1. Z99943, Z97876 Genomic DNA. Translation: CAI20147.1. CH471067 Genomic DNA. Translation: EAW90804.1. CH471067 Genomic DNA. Translation: EAW90807.1. BC117366 mRNA. Translation: AAI17367.1. BC117372 mRNA. Translation: AAI17373.1.
IPI	IPI00514661. IPI00641214. IPI00742726.
RefSeq	NP_001161221.1. NM_001167749.1. NP_060887.2. NM_018417.4.
UniGene	Hs.320892.
3D structure databases
ProteinModelPortal	Q96PN6.
SMR	Q96PN6. Positions 43-219, 1134-1162.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000356825.
PTM databases
PhosphoSite	Q96PN6.
Polymorphism databases
DMDM	308153637.
Proteomic databases
PaxDb	Q96PN6.
PRIDE	Q96PN6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000367848; ENSP00000356822; ENSG00000143199. ENST00000367851; ENSP00000356825; ENSG00000143199. ENST00000545172; ENSP00000441992; ENSG00000143199.
GeneID	55811.
KEGG	hsa:55811.
UCSC	uc001ger.3. human. uc009wvk.3. human.
Organism-specific databases
CTD	55811.
GeneCards	GC01M167778.
H-InvDB	HIX0200024.
HGNC	HGNC:21285. ADCY10.
HPA	HPA015243. HPA017749.
MIM	143870. phenotype. 605205. gene.
neXtProt	NX_Q96PN6.
Orphanet	2197. Idiopathic hypercalciuria.
PharmGKB	PA162375618.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG2114.
HOGENOM	HOG000060149.
HOVERGEN	HBG103835.
InParanoid	Q96PN6.
KO	K11265.
OMA	EGSCGIP.
OrthoDB	EOG4V6ZFR.
PhylomeDB	Q96PN6.
Gene expression databases
ArrayExpress	Q96PN6.
Bgee	Q96PN6.
CleanEx	HS_ADCY10.
Genevestigator	Q96PN6.
Family and domain databases
Gene3D	1.25.40.10. 1 hit. 3.30.70.1230. 2 hits.
InterPro	IPR001054. A/G_cyclase. IPR016577. Adenylate_cylcase_typ10. IPR011990. TPR-like_helical. [Graphical view]
Pfam	PF00211. Guanylate_cyc. 2 hits. [Graphical view]
PIRSF	PIRSF011131. Soluble_adenylyl_cyclase. 1 hit.
SMART	SM00044. CYCc. 1 hit. [Graphical view]
SUPFAM	SSF55073. A/G_cyclase. 1 hit.
PROSITE	PS00452. GUANYLATE_CYCLASE_1. False negative. PS50125. GUANYLATE_CYCLASE_2. 2 hits. [Graphical view]
ProtoNet	Search...
Other
BindingDB	Q96PN6.
ChEMBL	CHEMBL5854.
GenomeRNAi	55811.
NextBio	60977.
SOURCE	Search...

Entry information

Entry name

ADCYA_HUMAN

Accession

Primary (citable) accession number: Q96PN6
Secondary accession number(s): B4DZF0 , F5GWS5, O95558, Q5R329, Q5R330, Q8WXV4, Q9NNX0

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	October 5, 2010
Last modified:	May 1, 2013
This is version 93 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.