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Protein

RING finger and CHY zinc finger domain-containing protein 1

Gene

RCHY1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, P73, HDAC1 and CDKN1B. Preferentially acts on tetrameric p53/TP53. Monoubiquitinates the translesion DNA polymerase POLH. Contributes to the regulation of the cell cycle progression. Increases AR transcription factor activity.7 Publications

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri13 – 80CHY-typePROSITE-ProRule annotationAdd BLAST68
Zinc fingeri82 – 144CTCHY-typePROSITE-ProRule annotationAdd BLAST63
Zinc fingeri145 – 189RING-typePROSITE-ProRule annotationAdd BLAST45

GO - Molecular functioni

  • ligase activity Source: UniProtKB-KW
  • p53 binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • ubiquitin-protein transferase activity Source: UniProtKB
  • zinc ion binding Source: UniProtKB

GO - Biological processi

  • error-free translesion synthesis Source: Reactome
  • positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
  • positive regulation of protein ubiquitination Source: UniProtKB
  • protein autoubiquitination Source: UniProtKB
  • protein ubiquitination Source: UniProtKB
  • protein ubiquitination involved in ubiquitin-dependent protein catabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BRENDAi2.3.2.B10. 2681.
6.3.2.19. 2681.
ReactomeiR-HSA-110320. Translesion Synthesis by POLH.
R-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.
SIGNORiQ96PM5.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
RING finger and CHY zinc finger domain-containing protein 1 (EC:6.3.2.-)
Alternative name(s):
Androgen receptor N-terminal-interacting protein
CH-rich-interacting match with PLAG1
E3 ubiquitin-protein ligase Pirh2
RING finger protein 199
Zinc finger protein 363
p53-induced RING-H2 protein
Short name:
hPirh2
Gene namesi
Name:RCHY1
Synonyms:ARNIP, CHIMP, PIRH2, RNF199, ZNF363
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:17479. RCHY1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HGNC
  • nuclear speck Source: UniProtKB-SubCell
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
  • ubiquitin ligase complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi176M → E: Abolishes E3 ubiquitin-protein ligase activity. 1 Publication1
Mutagenesisi186C → A: Abolishes E3 ubiquitin-protein ligase activity. 1 Publication1

Organism-specific databases

DisGeNETi25898.
OpenTargetsiENSG00000163743.
PharmGKBiPA38240.

Polymorphism and mutation databases

BioMutaiRCHY1.
DMDMi32700008.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000563121 – 261RING finger and CHY zinc finger domain-containing protein 1Add BLAST261

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei257PhosphoserineCombined sources1

Post-translational modificationi

Subject to ubiquitination and proteasomal degradation. Interaction with PLAGL2 or KAT5 enhances protein stability.2 Publications

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ96PM5.
MaxQBiQ96PM5.
PaxDbiQ96PM5.
PeptideAtlasiQ96PM5.
PRIDEiQ96PM5.

2D gel databases

REPRODUCTION-2DPAGEQ96PM5.

PTM databases

iPTMnetiQ96PM5.
PhosphoSitePlusiQ96PM5.

Expressioni

Inductioni

Up-regulated during the S phase of the cell cycle. Expressed at low levels during G phase.

Gene expression databases

BgeeiENSG00000163743.
CleanExiHS_RCHY1.
ExpressionAtlasiQ96PM5. baseline and differential.
GenevisibleiQ96PM5. HS.

Organism-specific databases

HPAiHPA030339.

Interactioni

Subunit structurei

Monomer and homodimer. Interacts with AR, p53/TP53, MDM2, HDAC1, KAT5, PLAG1, PLAGL2, CDKN1B, COPE, UBE2D2 and GORAB/NTKLBP1.8 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ADAMTSL4Q6UY14-33EBI-947779,EBI-10173507
AIG1Q9NVV54EBI-947779,EBI-3942989
ANGPTL8Q6UXH02EBI-947779,EBI-3943039
ARF4P180853EBI-947779,EBI-1237085
CALM3P621582EBI-947779,EBI-397435
HRGP041963EBI-947779,EBI-3915012
KLHL41O606623EBI-947779,EBI-5353084
KRTAP9-2Q9BYQ43EBI-947779,EBI-1044640
LIMS2Q7Z4I7-53EBI-947779,EBI-10257651
MEOX2A4D1273EBI-947779,EBI-10172134
NKD2Q969F22EBI-947779,EBI-1538629
NLKQ9UBE85EBI-947779,EBI-366978
NOTCH2NLQ7Z3S93EBI-947779,EBI-945833
SEMA4CQ9C0C43EBI-947779,EBI-10303490
TP53P046377EBI-947779,EBI-366083
UBASH3BQ8TF423EBI-947779,EBI-1380492
WDR74Q6RFH53EBI-947779,EBI-722366

GO - Molecular functioni

  • p53 binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi117406. 82 interactors.
DIPiDIP-43981N.
IntActiQ96PM5. 48 interactors.
MINTiMINT-3057007.
STRINGi9606.ENSP00000321239.

Structurei

Secondary structure

1261
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi26 – 30Combined sources5
Turni32 – 34Combined sources3
Beta strandi37 – 40Combined sources4
Helixi41 – 47Combined sources7
Beta strandi48 – 50Combined sources3
Turni54 – 56Combined sources3
Beta strandi59 – 62Combined sources4
Turni63 – 65Combined sources3
Beta strandi68 – 71Combined sources4
Turni76 – 78Combined sources3
Beta strandi84 – 87Combined sources4
Turni88 – 91Combined sources4
Beta strandi92 – 94Combined sources3
Beta strandi100 – 102Combined sources3
Turni103 – 106Combined sources4
Beta strandi107 – 110Combined sources4
Turni113 – 115Combined sources3
Beta strandi116 – 119Combined sources4
Turni120 – 123Combined sources4
Beta strandi124 – 127Combined sources4
Turni128 – 132Combined sources5
Turni146 – 149Combined sources4
Turni156 – 158Combined sources3
Beta strandi159 – 161Combined sources3
Beta strandi167 – 169Combined sources3
Helixi170 – 179Combined sources10
Helixi184 – 187Combined sources4
Beta strandi217 – 225Combined sources9
Beta strandi228 – 232Combined sources5
Turni241 – 243Combined sources3
Beta strandi248 – 251Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JRJNMR-A143-189[»]
2K2CNMR-A1-137[»]
2K2DNMR-A187-261[»]
ProteinModelPortaliQ96PM5.
SMRiQ96PM5.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96PM5.

Family & Domainsi

Sequence similaritiesi

Contains 1 CHY-type zinc finger.PROSITE-ProRule annotation
Contains 1 CTCHY-type zinc finger.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri13 – 80CHY-typePROSITE-ProRule annotationAdd BLAST68
Zinc fingeri82 – 144CTCHY-typePROSITE-ProRule annotationAdd BLAST63
Zinc fingeri145 – 189RING-typePROSITE-ProRule annotationAdd BLAST45

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG1940. Eukaryota.
ENOG410XXHF. LUCA.
GeneTreeiENSGT00390000008853.
HOGENOMiHOG000231827.
HOVERGENiHBG062959.
InParanoidiQ96PM5.
KOiK10144.
OMAiCGSYNTA.
OrthoDBiEOG091G094U.
PhylomeDBiQ96PM5.
TreeFamiTF323762.

Family and domain databases

Gene3Di2.20.28.10. 1 hit.
3.30.40.10. 1 hit.
InterProiIPR004039. Rubredoxin-type_fold.
IPR008913. Znf_CHY.
IPR017921. Znf_CTCHY.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF05495. zf-CHY. 1 hit.
PF13639. zf-RING_2. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS51266. ZF_CHY. 1 hit.
PS51270. ZF_CTCHY. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (8)i

Sequence statusi: Complete.

This entry describes 8 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96PM5-1) [UniParc]FASTAAdd to basket
Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAATAREDGA SGQERGQRGC EHYDRGCLLK APCCDKLYTC RLCHDNNEDH
60 70 80 90 100
QLDRFKVKEV QCINCEKIQH AQQTCEECST LFGEYYCDIC HLFDKDKKQY
110 120 130 140 150
HCENCGICRI GPKEDFFHCL KCNLCLAMNL QGRHKCIENV SRQNCPICLE
160 170 180 190 200
DIHTSRVVAH VLPCGHLLHR TCYEEMLKEG YRCPLCMHSA LDMTRYWRQL
210 220 230 240 250
DDEVAQTPMP SEYQNMTVDI LCNDCNGRST VQFHILGMKC KICESYNTAQ
260
AGGRRISLDQ Q
Length:261
Mass (Da):30,110
Last modified:December 1, 2001 - v1
Checksum:iAC03786F6B42A03D
GO
Isoform 2 (identifier: Q96PM5-2) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     171-179: Missing.

Show »
Length:252
Mass (Da):28,983
Checksum:i0079B97723751278
GO
Isoform 3 (identifier: Q96PM5-3) [UniParc]FASTAAdd to basket
Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     180-261: Missing.

Show »
Length:179
Mass (Da):20,720
Checksum:iB38F75D4374FA2F8
GO
Isoform 4 (identifier: Q96PM5-4) [UniParc]FASTAAdd to basket
Also known as: Pirh2b

The sequence of this isoform differs from the canonical sequence as follows:
     180-261: GYRCPLCMHS...GGRRISLDQQ → YDQVLETAG

Note: No ubiquitin protein ligase activity. Down-regulated in hepatocellular carcinoma.
Show »
Length:188
Mass (Da):21,697
Checksum:i0DEFC07DCEDBA3A7
GO
Isoform 5 (identifier: Q96PM5-5) [UniParc]FASTAAdd to basket
Also known as: Pirh2D

The sequence of this isoform differs from the canonical sequence as follows:
     68-75: IQHAQQTC → NSTCPTDL
     76-261: Missing.

Show »
Length:75
Mass (Da):8,494
Checksum:i2FE97DE89608DE6D
GO
Isoform 6 (identifier: Q96PM5-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-30: MAATAREDGASGQERGQRGCEHYDRGCLLK → MAPAVKSE

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:239
Mass (Da):27,676
Checksum:i0DD872A14E2E217A
GO
Isoform 7 (identifier: Q96PM5-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     31-70: Missing.

Note: No experimental confirmation available. Gene prediction based on partial mRNA data.
Show »
Length:221
Mass (Da):25,337
Checksum:i7B96797039B25C4D
GO
Isoform 8 (identifier: Q96PM5-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     31-70: Missing.
     171-179: Missing.

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:212
Mass (Da):24,210
Checksum:iA4EA203D3FBB7F21
GO

Sequence cautioni

The sequence BAD92309 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11 – 13SGQ → TGE in ACT35531 (PubMed:19483087).Curated3
Sequence conflicti11 – 13SGQ → TGE in ACT35532 (PubMed:19483087).Curated3
Sequence conflicti11 – 13SGQ → TGE in ACT35533 (PubMed:19483087).Curated3
Sequence conflicti11 – 13SGQ → TGE in AAK96896 (Ref. 3) Curated3
Sequence conflicti142R → Q in AAH47393 (PubMed:15489334).Curated1
Sequence conflicti220I → F in BAD92309 (Ref. 8) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0537871 – 30MAATA…GCLLK → MAPAVKSE in isoform 6. CuratedAdd BLAST30
Alternative sequenceiVSP_05378831 – 70Missing in isoform 7 and isoform 8. CuratedAdd BLAST40
Alternative sequenceiVSP_05338568 – 75IQHAQQTC → NSTCPTDL in isoform 5. 1 Publication8
Alternative sequenceiVSP_05338676 – 261Missing in isoform 5. 1 PublicationAdd BLAST186
Alternative sequenceiVSP_038467171 – 179Missing in isoform 2 and isoform 8. 1 Publication9
Alternative sequenceiVSP_038468180 – 261Missing in isoform 3. 1 PublicationAdd BLAST82
Alternative sequenceiVSP_044085180 – 261GYRCP…SLDQQ → YDQVLETAG in isoform 4. 1 PublicationAdd BLAST82

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GQ250944 mRNA. Translation: ACT35531.1.
GQ250945 mRNA. Translation: ACT35532.1.
GQ250946 mRNA. Translation: ACT35533.1.
AF247041 mRNA. Translation: AAL76101.1.
AF255666 mRNA. Translation: AAK96896.1.
AF305424 mRNA. Translation: AAL09356.1.
AB209072 mRNA. Translation: BAD92309.1. Different initiation.
AY888047 mRNA. Translation: AAX78233.1.
GU937000 mRNA. Translation: ADD21555.1.
AK091501 mRNA. Translation: BAG52375.1.
AC096759 Genomic DNA. No translation available.
CH471057 Genomic DNA. Translation: EAX05725.1.
BC047393 mRNA. Translation: AAH47393.1.
CCDSiCCDS34012.1. [Q96PM5-2]
CCDS3567.1. [Q96PM5-1]
CCDS63990.1. [Q96PM5-8]
CCDS63991.1. [Q96PM5-7]
CCDS63992.1. [Q96PM5-6]
RefSeqiNP_001009922.1. NM_001009922.2. [Q96PM5-2]
NP_001265465.1. NM_001278536.1. [Q96PM5-7]
NP_001265466.1. NM_001278537.1. [Q96PM5-8]
NP_001265467.1. NM_001278538.1. [Q96PM5-6]
NP_056251.2. NM_015436.3. [Q96PM5-1]
UniGeneiHs.48297.

Genome annotation databases

EnsembliENST00000324439; ENSP00000321239; ENSG00000163743. [Q96PM5-1]
ENST00000380840; ENSP00000370220; ENSG00000163743. [Q96PM5-7]
ENST00000505105; ENSP00000424631; ENSG00000163743. [Q96PM5-4]
ENST00000507014; ENSP00000424472; ENSG00000163743. [Q96PM5-8]
ENST00000512706; ENSP00000423976; ENSG00000163743. [Q96PM5-6]
ENST00000513257; ENSP00000421084; ENSG00000163743. [Q96PM5-2]
GeneIDi25898.
KEGGihsa:25898.
UCSCiuc003hik.4. human. [Q96PM5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GQ250944 mRNA. Translation: ACT35531.1.
GQ250945 mRNA. Translation: ACT35532.1.
GQ250946 mRNA. Translation: ACT35533.1.
AF247041 mRNA. Translation: AAL76101.1.
AF255666 mRNA. Translation: AAK96896.1.
AF305424 mRNA. Translation: AAL09356.1.
AB209072 mRNA. Translation: BAD92309.1. Different initiation.
AY888047 mRNA. Translation: AAX78233.1.
GU937000 mRNA. Translation: ADD21555.1.
AK091501 mRNA. Translation: BAG52375.1.
AC096759 Genomic DNA. No translation available.
CH471057 Genomic DNA. Translation: EAX05725.1.
BC047393 mRNA. Translation: AAH47393.1.
CCDSiCCDS34012.1. [Q96PM5-2]
CCDS3567.1. [Q96PM5-1]
CCDS63990.1. [Q96PM5-8]
CCDS63991.1. [Q96PM5-7]
CCDS63992.1. [Q96PM5-6]
RefSeqiNP_001009922.1. NM_001009922.2. [Q96PM5-2]
NP_001265465.1. NM_001278536.1. [Q96PM5-7]
NP_001265466.1. NM_001278537.1. [Q96PM5-8]
NP_001265467.1. NM_001278538.1. [Q96PM5-6]
NP_056251.2. NM_015436.3. [Q96PM5-1]
UniGeneiHs.48297.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JRJNMR-A143-189[»]
2K2CNMR-A1-137[»]
2K2DNMR-A187-261[»]
ProteinModelPortaliQ96PM5.
SMRiQ96PM5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117406. 82 interactors.
DIPiDIP-43981N.
IntActiQ96PM5. 48 interactors.
MINTiMINT-3057007.
STRINGi9606.ENSP00000321239.

PTM databases

iPTMnetiQ96PM5.
PhosphoSitePlusiQ96PM5.

Polymorphism and mutation databases

BioMutaiRCHY1.
DMDMi32700008.

2D gel databases

REPRODUCTION-2DPAGEQ96PM5.

Proteomic databases

EPDiQ96PM5.
MaxQBiQ96PM5.
PaxDbiQ96PM5.
PeptideAtlasiQ96PM5.
PRIDEiQ96PM5.

Protocols and materials databases

DNASUi25898.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000324439; ENSP00000321239; ENSG00000163743. [Q96PM5-1]
ENST00000380840; ENSP00000370220; ENSG00000163743. [Q96PM5-7]
ENST00000505105; ENSP00000424631; ENSG00000163743. [Q96PM5-4]
ENST00000507014; ENSP00000424472; ENSG00000163743. [Q96PM5-8]
ENST00000512706; ENSP00000423976; ENSG00000163743. [Q96PM5-6]
ENST00000513257; ENSP00000421084; ENSG00000163743. [Q96PM5-2]
GeneIDi25898.
KEGGihsa:25898.
UCSCiuc003hik.4. human. [Q96PM5-1]

Organism-specific databases

CTDi25898.
DisGeNETi25898.
GeneCardsiRCHY1.
HGNCiHGNC:17479. RCHY1.
HPAiHPA030339.
MIMi607680. gene.
neXtProtiNX_Q96PM5.
OpenTargetsiENSG00000163743.
PharmGKBiPA38240.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1940. Eukaryota.
ENOG410XXHF. LUCA.
GeneTreeiENSGT00390000008853.
HOGENOMiHOG000231827.
HOVERGENiHBG062959.
InParanoidiQ96PM5.
KOiK10144.
OMAiCGSYNTA.
OrthoDBiEOG091G094U.
PhylomeDBiQ96PM5.
TreeFamiTF323762.

Enzyme and pathway databases

UniPathwayiUPA00143.
BRENDAi2.3.2.B10. 2681.
6.3.2.19. 2681.
ReactomeiR-HSA-110320. Translesion Synthesis by POLH.
R-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.
SIGNORiQ96PM5.

Miscellaneous databases

ChiTaRSiRCHY1. human.
EvolutionaryTraceiQ96PM5.
GeneWikiiRCHY1.
GenomeRNAii25898.
PROiQ96PM5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163743.
CleanExiHS_RCHY1.
ExpressionAtlasiQ96PM5. baseline and differential.
GenevisibleiQ96PM5. HS.

Family and domain databases

Gene3Di2.20.28.10. 1 hit.
3.30.40.10. 1 hit.
InterProiIPR004039. Rubredoxin-type_fold.
IPR008913. Znf_CHY.
IPR017921. Znf_CTCHY.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF05495. zf-CHY. 1 hit.
PF13639. zf-RING_2. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS51266. ZF_CHY. 1 hit.
PS51270. ZF_CTCHY. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN363_HUMAN
AccessioniPrimary (citable) accession number: Q96PM5
Secondary accession number(s): B3KRG3
, C7E541, C7E542, C7E543, D3YRV2, E7EMC8, E7ETW5, J3KPI0, Q2KN33, Q59GN7, Q86X26, Q96PR5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 145 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.