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Q96PL2

- TECTB_HUMAN

UniProt

Q96PL2 - TECTB_HUMAN

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Protein

Beta-tectorin

Gene

TECTB

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-tectorin
Gene namesi
Name:TECTB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:11721. TECTB.

Subcellular locationi

Cell membrane Curated; Lipid-anchorGPI-anchor Curated; Extracellular side Curated. Secretedextracellular spaceextracellular matrix
Note: Found in the non-collagenous matrix of the tectorial membrane.By similarity

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
  3. proteinaceous extracellular matrix Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Extracellular matrix, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36438.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Chaini18 – 305288Beta-tectorinPRO_0000041741Add
BLAST
Propeptidei306 – 32924Removed in mature formSequence AnalysisPRO_0000041742Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi80 – 801N-linked (GlcNAc...)Sequence Analysis
Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence Analysis
Glycosylationi116 – 1161N-linked (GlcNAc...)Sequence Analysis
Glycosylationi145 – 1451N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi204 ↔ 264By similarity
Lipidationi305 – 3051GPI-anchor amidated glycineSequence Analysis

Post-translational modificationi

The presence of a hydrophobic C-terminus preceded by a potential cleavage site strongly suggests that tectorins are synthesized as glycosylphosphatidylinositol-linked, membrane-bound precursors. Tectorins are targeted to the apical surface of the inner ear epithelia by the lipid and proteolytically released into the extracellular compartment.

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ96PL2.
PRIDEiQ96PL2.

Expressioni

Gene expression databases

BgeeiQ96PL2.
CleanExiHS_TECTB.
GenevestigatoriQ96PL2.

Interactioni

Subunit structurei

May form homomeric filament after self-association or heteromeric filament after association with alpha-tectorin.

Protein-protein interaction databases

BioGridi112835. 1 interaction.
STRINGi9606.ENSP00000358430.

Structurei

3D structure databases

ProteinModelPortaliQ96PL2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 283265ZPPROSITE-ProRule annotationAdd
BLAST

Domaini

Zona pellucida domain may enable to form filaments.

Sequence similaritiesi

Contains 1 ZP domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG44475.
GeneTreeiENSGT00530000063315.
HOGENOMiHOG000124070.
HOVERGENiHBG056825.
InParanoidiQ96PL2.
OMAiNNCWATP.
OrthoDBiEOG7060R8.
PhylomeDBiQ96PL2.
TreeFamiTF330284.

Family and domain databases

InterProiIPR001507. ZP_dom.
IPR017977. ZP_dom_CS.
[Graphical view]
PfamiPF00100. Zona_pellucida. 1 hit.
[Graphical view]
PRINTSiPR00023. ZPELLUCIDA.
SMARTiSM00241. ZP. 1 hit.
[Graphical view]
PROSITEiPS00682. ZP_1. 1 hit.
PS51034. ZP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96PL2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVTKAFVLLA IFAEASAKSC APNKADVILV FCYPKTIITK IPECPYGWEV
60 70 80 90 100
HQLALGGLCY NGVHEGGYYQ FVIPDLSPKN KSYCGTQSEY KPPIYHFYSH
110 120 130 140 150
IVSNDTTVIV KNQPVNYSFS CTYHSTYLVN QAAFDQRVAT VHVKNGSMGT
160 170 180 190 200
FESQLSLNFY TNAKFSIKKE APFVLEASEI GSDLFAGVEA KGLSIRFKVV
210 220 230 240 250
LNSCWATPSA DFMYPLQWQL INKGCPTDET VLVHENGRDH RATFQFNAFR
260 270 280 290 300
FQNIPKLSKV WLHCETFICD SEKLSCPVTC DKRKRLLRDQ TGGVLVVELS
310 320
LRSRGFSSLY SFSDVLHHLI MMLGICAVL
Length:329
Mass (Da):36,956
Last modified:December 1, 2001 - v1
Checksum:i0B4D379624F488D0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF312827 mRNA. Translation: AAL12829.1.
AL391986 Genomic DNA. Translation: CAH73718.1.
BC113497 mRNA. Translation: AAI13498.1.
BC113499 mRNA. Translation: AAI13500.1.
CCDSiCCDS7571.1.
RefSeqiNP_478129.1. NM_058222.2.
XP_005270164.1. XM_005270107.1.
UniGeneiHs.345485.
Hs.348615.

Genome annotation databases

EnsembliENST00000369422; ENSP00000358430; ENSG00000119913.
GeneIDi6975.
KEGGihsa:6975.
UCSCiuc001kzr.1. human.

Polymorphism databases

DMDMi48428669.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF312827 mRNA. Translation: AAL12829.1 .
AL391986 Genomic DNA. Translation: CAH73718.1 .
BC113497 mRNA. Translation: AAI13498.1 .
BC113499 mRNA. Translation: AAI13500.1 .
CCDSi CCDS7571.1.
RefSeqi NP_478129.1. NM_058222.2.
XP_005270164.1. XM_005270107.1.
UniGenei Hs.345485.
Hs.348615.

3D structure databases

ProteinModelPortali Q96PL2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112835. 1 interaction.
STRINGi 9606.ENSP00000358430.

Polymorphism databases

DMDMi 48428669.

Proteomic databases

PaxDbi Q96PL2.
PRIDEi Q96PL2.

Protocols and materials databases

DNASUi 6975.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000369422 ; ENSP00000358430 ; ENSG00000119913 .
GeneIDi 6975.
KEGGi hsa:6975.
UCSCi uc001kzr.1. human.

Organism-specific databases

CTDi 6975.
GeneCardsi GC10P114033.
HGNCi HGNC:11721. TECTB.
MIMi 602653. gene.
neXtProti NX_Q96PL2.
PharmGKBi PA36438.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG44475.
GeneTreei ENSGT00530000063315.
HOGENOMi HOG000124070.
HOVERGENi HBG056825.
InParanoidi Q96PL2.
OMAi NNCWATP.
OrthoDBi EOG7060R8.
PhylomeDBi Q96PL2.
TreeFami TF330284.

Miscellaneous databases

GeneWikii TECTB.
GenomeRNAii 6975.
NextBioi 27277.
PROi Q96PL2.
SOURCEi Search...

Gene expression databases

Bgeei Q96PL2.
CleanExi HS_TECTB.
Genevestigatori Q96PL2.

Family and domain databases

InterProi IPR001507. ZP_dom.
IPR017977. ZP_dom_CS.
[Graphical view ]
Pfami PF00100. Zona_pellucida. 1 hit.
[Graphical view ]
PRINTSi PR00023. ZPELLUCIDA.
SMARTi SM00241. ZP. 1 hit.
[Graphical view ]
PROSITEi PS00682. ZP_1. 1 hit.
PS51034. ZP_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and identification of human TECTB."
    Xia J.H., Zhang H.L., Deng H., Lu C.Y., Pang Q.
    Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiTECTB_HUMAN
AccessioniPrimary (citable) accession number: Q96PL2
Secondary accession number(s): Q5VW53
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3