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Q96PL2 (TECTB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-tectorin
Gene names
Name:TECTB
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length329 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

One of the major non-collagenous components of the tectorial membrane By similarity. The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals.

Subunit structure

May form homomeric filament after self-association or heteromeric filament after association with alpha-tectorin.

Subcellular location

Cell membrane; Lipid-anchorGPI-anchor; Extracellular side Probable. Secretedextracellular spaceextracellular matrix. Note: Found in the non-collagenous matrix of the tectorial membrane By similarity.

Domain

Zona pellucida domain may enable to form filaments.

Post-translational modification

The presence of a hydrophobic C-terminus preceded by a potential cleavage site strongly suggests that tectorins are synthesized as glycosylphosphatidylinositol-linked, membrane-bound precursors. Tectorins are targeted to the apical surface of the inner ear epithelia by the lipid and proteolytically released into the extracellular compartment.

Sequence similarities

Contains 1 ZP domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Chain18 – 305288Beta-tectorin
PRO_0000041741
Propeptide306 – 32924Removed in mature form Potential
PRO_0000041742

Regions

Domain19 – 283265ZP

Amino acid modifications

Lipidation3051GPI-anchor amidated glycine Potential
Glycosylation801N-linked (GlcNAc...) Potential
Glycosylation1041N-linked (GlcNAc...) Potential
Glycosylation1161N-linked (GlcNAc...) Potential
Glycosylation1451N-linked (GlcNAc...) Potential
Disulfide bond204 ↔ 264 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q96PL2 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 0B4D379624F488D0

FASTA32936,956
        10         20         30         40         50         60 
MVTKAFVLLA IFAEASAKSC APNKADVILV FCYPKTIITK IPECPYGWEV HQLALGGLCY 

        70         80         90        100        110        120 
NGVHEGGYYQ FVIPDLSPKN KSYCGTQSEY KPPIYHFYSH IVSNDTTVIV KNQPVNYSFS 

       130        140        150        160        170        180 
CTYHSTYLVN QAAFDQRVAT VHVKNGSMGT FESQLSLNFY TNAKFSIKKE APFVLEASEI 

       190        200        210        220        230        240 
GSDLFAGVEA KGLSIRFKVV LNSCWATPSA DFMYPLQWQL INKGCPTDET VLVHENGRDH 

       250        260        270        280        290        300 
RATFQFNAFR FQNIPKLSKV WLHCETFICD SEKLSCPVTC DKRKRLLRDQ TGGVLVVELS 

       310        320 
LRSRGFSSLY SFSDVLHHLI MMLGICAVL 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and identification of human TECTB."
Xia J.H., Zhang H.L., Deng H., Lu C.Y., Pang Q.
Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF312827 mRNA. Translation: AAL12829.1.
AL391986 Genomic DNA. Translation: CAH73718.1.
BC113497 mRNA. Translation: AAI13498.1.
BC113499 mRNA. Translation: AAI13500.1.
CCDSCCDS7571.1.
RefSeqNP_478129.1. NM_058222.2.
XP_005270164.1. XM_005270107.1.
UniGeneHs.345485.
Hs.348615.

3D structure databases

ProteinModelPortalQ96PL2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000358430.

Polymorphism databases

DMDM48428669.

Proteomic databases

PaxDbQ96PL2.
PRIDEQ96PL2.

Protocols and materials databases

DNASU6975.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000369422; ENSP00000358430; ENSG00000119913.
GeneID6975.
KEGGhsa:6975.
UCSCuc001kzr.1. human.

Organism-specific databases

CTD6975.
GeneCardsGC10P114033.
HGNCHGNC:11721. TECTB.
MIM602653. gene.
neXtProtNX_Q96PL2.
PharmGKBPA36438.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG44475.
HOGENOMHOG000124070.
HOVERGENHBG056825.
InParanoidQ96PL2.
OMANNCWATP.
OrthoDBEOG7060R8.
PhylomeDBQ96PL2.
TreeFamTF330284.

Gene expression databases

BgeeQ96PL2.
CleanExHS_TECTB.
GenevestigatorQ96PL2.

Family and domain databases

InterProIPR001507. ZP_dom.
IPR017977. ZP_dom_CS.
[Graphical view]
PfamPF00100. Zona_pellucida. 1 hit.
[Graphical view]
PRINTSPR00023. ZPELLUCIDA.
SMARTSM00241. ZP. 1 hit.
[Graphical view]
PROSITEPS00682. ZP_1. 1 hit.
PS51034. ZP_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiTECTB.
GenomeRNAi6975.
NextBio27277.
PROQ96PL2.
SOURCESearch...

Entry information

Entry nameTECTB_HUMAN
AccessionPrimary (citable) accession number: Q96PL2
Secondary accession number(s): Q5VW53
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM