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Protein

Beta-tectorin

Gene

TECTB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-tectorin
Gene namesi
Name:TECTB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:11721. TECTB.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Extracellular matrix, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36438.

Polymorphism and mutation databases

DMDMi48428669.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Chaini18 – 305288Beta-tectorinPRO_0000041741Add
BLAST
Propeptidei306 – 32924Removed in mature formSequence AnalysisPRO_0000041742Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi80 – 801N-linked (GlcNAc...)Sequence Analysis
Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence Analysis
Glycosylationi116 – 1161N-linked (GlcNAc...)Sequence Analysis
Glycosylationi145 – 1451N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi204 ↔ 264By similarity
Lipidationi305 – 3051GPI-anchor amidated glycineSequence Analysis

Post-translational modificationi

The presence of a hydrophobic C-terminus preceded by a potential cleavage site strongly suggests that tectorins are synthesized as glycosylphosphatidylinositol-linked, membrane-bound precursors. Tectorins are targeted to the apical surface of the inner ear epithelia by the lipid and proteolytically released into the extracellular compartment.

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ96PL2.
PRIDEiQ96PL2.

Expressioni

Gene expression databases

BgeeiQ96PL2.
CleanExiHS_TECTB.
GenevisibleiQ96PL2. HS.

Interactioni

Subunit structurei

May form homomeric filament after self-association or heteromeric filament after association with alpha-tectorin.

Protein-protein interaction databases

STRINGi9606.ENSP00000358430.

Structurei

3D structure databases

ProteinModelPortaliQ96PL2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 283265ZPPROSITE-ProRule annotationAdd
BLAST

Domaini

Zona pellucida domain may enable to form filaments.

Sequence similaritiesi

Contains 1 ZP domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG44475.
GeneTreeiENSGT00530000063315.
HOGENOMiHOG000124070.
HOVERGENiHBG056825.
InParanoidiQ96PL2.
OMAiNNCWATP.
OrthoDBiEOG7060R8.
PhylomeDBiQ96PL2.
TreeFamiTF330284.

Family and domain databases

InterProiIPR001507. ZP_dom.
IPR017977. ZP_dom_CS.
[Graphical view]
PfamiPF00100. Zona_pellucida. 1 hit.
[Graphical view]
PRINTSiPR00023. ZPELLUCIDA.
SMARTiSM00241. ZP. 1 hit.
[Graphical view]
PROSITEiPS00682. ZP_1. 1 hit.
PS51034. ZP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96PL2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTKAFVLLA IFAEASAKSC APNKADVILV FCYPKTIITK IPECPYGWEV
60 70 80 90 100
HQLALGGLCY NGVHEGGYYQ FVIPDLSPKN KSYCGTQSEY KPPIYHFYSH
110 120 130 140 150
IVSNDTTVIV KNQPVNYSFS CTYHSTYLVN QAAFDQRVAT VHVKNGSMGT
160 170 180 190 200
FESQLSLNFY TNAKFSIKKE APFVLEASEI GSDLFAGVEA KGLSIRFKVV
210 220 230 240 250
LNSCWATPSA DFMYPLQWQL INKGCPTDET VLVHENGRDH RATFQFNAFR
260 270 280 290 300
FQNIPKLSKV WLHCETFICD SEKLSCPVTC DKRKRLLRDQ TGGVLVVELS
310 320
LRSRGFSSLY SFSDVLHHLI MMLGICAVL
Length:329
Mass (Da):36,956
Last modified:December 1, 2001 - v1
Checksum:i0B4D379624F488D0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF312827 mRNA. Translation: AAL12829.1.
AL391986 Genomic DNA. Translation: CAH73718.1.
BC113497 mRNA. Translation: AAI13498.1.
BC113499 mRNA. Translation: AAI13500.1.
CCDSiCCDS7571.1.
RefSeqiNP_478129.1. NM_058222.2.
XP_005270164.1. XM_005270107.2.
UniGeneiHs.345485.
Hs.348615.

Genome annotation databases

EnsembliENST00000369422; ENSP00000358430; ENSG00000119913.
GeneIDi6975.
KEGGihsa:6975.
UCSCiuc001kzr.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF312827 mRNA. Translation: AAL12829.1.
AL391986 Genomic DNA. Translation: CAH73718.1.
BC113497 mRNA. Translation: AAI13498.1.
BC113499 mRNA. Translation: AAI13500.1.
CCDSiCCDS7571.1.
RefSeqiNP_478129.1. NM_058222.2.
XP_005270164.1. XM_005270107.2.
UniGeneiHs.345485.
Hs.348615.

3D structure databases

ProteinModelPortaliQ96PL2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000358430.

Polymorphism and mutation databases

DMDMi48428669.

Proteomic databases

PaxDbiQ96PL2.
PRIDEiQ96PL2.

Protocols and materials databases

DNASUi6975.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369422; ENSP00000358430; ENSG00000119913.
GeneIDi6975.
KEGGihsa:6975.
UCSCiuc001kzr.1. human.

Organism-specific databases

CTDi6975.
GeneCardsiGC10P114033.
HGNCiHGNC:11721. TECTB.
MIMi602653. gene.
neXtProtiNX_Q96PL2.
PharmGKBiPA36438.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG44475.
GeneTreeiENSGT00530000063315.
HOGENOMiHOG000124070.
HOVERGENiHBG056825.
InParanoidiQ96PL2.
OMAiNNCWATP.
OrthoDBiEOG7060R8.
PhylomeDBiQ96PL2.
TreeFamiTF330284.

Miscellaneous databases

GeneWikiiTECTB.
GenomeRNAii6975.
NextBioi27277.
PROiQ96PL2.
SOURCEiSearch...

Gene expression databases

BgeeiQ96PL2.
CleanExiHS_TECTB.
GenevisibleiQ96PL2. HS.

Family and domain databases

InterProiIPR001507. ZP_dom.
IPR017977. ZP_dom_CS.
[Graphical view]
PfamiPF00100. Zona_pellucida. 1 hit.
[Graphical view]
PRINTSiPR00023. ZPELLUCIDA.
SMARTiSM00241. ZP. 1 hit.
[Graphical view]
PROSITEiPS00682. ZP_1. 1 hit.
PS51034. ZP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and identification of human TECTB."
    Xia J.H., Zhang H.L., Deng H., Lu C.Y., Pang Q.
    Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiTECTB_HUMAN
AccessioniPrimary (citable) accession number: Q96PL2
Secondary accession number(s): Q5VW53
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: December 1, 2001
Last modified: June 24, 2015
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.