Q96PL2 (TECTB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Beta-tectorin

Gene names

Name:

TECTB

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	329 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	One of the major non-collagenous components of the tectorial membrane By similarity. The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals.
Subunit structure	May form homomeric filament after self-association or heteromeric filament after association with alpha-tectorin.
Subcellular location	Cell membrane; Lipid-anchor › GPI-anchor; Extracellular side Probable. Secreted › extracellular space › extracellular matrix. Note: Found in the non-collagenous matrix of the tectorial membrane By similarity.
Domain	Zona pellucida domain may enable to form filaments.
Post-translational modification	The presence of a hydrophobic C-terminus preceded by a potential cleavage site strongly suggests that tectorins are synthesized as glycosylphosphatidylinositol-linked, membrane-bound precursors. Tectorins are targeted to the apical surface of the inner ear epithelia by the lipid and proteolytically released into the extracellular compartment.
Sequence similarities	Contains 1 ZP domain.

Ontologies

Keywords
Cellular component	Cell membrane Extracellular matrix Membrane Secreted
Domain	Signal
PTM	Disulfide bond GPI-anchor Glycoprotein Lipoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	anchored to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell proteinaceous extracellular matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 17	17	Potential
	Chain	18 – 305	288	Beta-tectorin		PRO_0000041741
	Propeptide	306 – 329	24	Removed in mature form Potential		PRO_0000041742
Regions
	Domain	19 – 283	265	ZP
Amino acid modifications
	Lipidation	305	1	GPI-anchor amidated glycine Potential
	Glycosylation	80	1	N-linked (GlcNAc...) Potential
	Glycosylation	104	1	N-linked (GlcNAc...) Potential
	Glycosylation	116	1	N-linked (GlcNAc...) Potential
	Glycosylation	145	1	N-linked (GlcNAc...) Potential
	Disulfide bond	204 ↔ 264		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q96PL2 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 0B4D379624F488D0	FASTA	329	36,956
	10 20 30 40 50 60 MVTKAFVLLA IFAEASAKSC APNKADVILV FCYPKTIITK IPECPYGWEV HQLALGGLCY 70 80 90 100 110 120 NGVHEGGYYQ FVIPDLSPKN KSYCGTQSEY KPPIYHFYSH IVSNDTTVIV KNQPVNYSFS 130 140 150 160 170 180 CTYHSTYLVN QAAFDQRVAT VHVKNGSMGT FESQLSLNFY TNAKFSIKKE APFVLEASEI 190 200 210 220 230 240 GSDLFAGVEA KGLSIRFKVV LNSCWATPSA DFMYPLQWQL INKGCPTDET VLVHENGRDH 250 260 270 280 290 300 RATFQFNAFR FQNIPKLSKV WLHCETFICD SEKLSCPVTC DKRKRLLRDQ TGGVLVVELS 310 320 LRSRGFSSLY SFSDVLHHLI MMLGICAVL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and identification of human TECTB." Xia J.H., Zhang H.L., Deng H., Lu C.Y., Pang Q. Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[2]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF312827 mRNA. Translation: AAL12829.1. AL391986 Genomic DNA. Translation: CAH73718.1. BC113497 mRNA. Translation: AAI13498.1. BC113499 mRNA. Translation: AAI13500.1.
IPI	IPI00044552.
RefSeq	NP_478129.1. NM_058222.1.
UniGene	Hs.348615.
3D structure databases
ProteinModelPortal	Q96PL2.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000358430.
Polymorphism databases
DMDM	48428669.
Proteomic databases
PaxDb	Q96PL2.
PRIDE	Q96PL2.
Protocols and materials databases
DNASU	6975.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000369422; ENSP00000358430; ENSG00000119913.
GeneID	6975.
KEGG	hsa:6975.
UCSC	uc001kzr.1. human.
Organism-specific databases
CTD	6975.
GeneCards	GC10P114033.
HGNC	HGNC:11721. TECTB.
MIM	602653. gene.
neXtProt	NX_Q96PL2.
PharmGKB	PA36438.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG44475.
HOGENOM	HOG000124070.
HOVERGEN	HBG056825.
InParanoid	Q96PL2.
OMA	FSDVLYH.
OrthoDB	EOG4ZPDVR.
PhylomeDB	Q96PL2.
Gene expression databases
Bgee	Q96PL2.
CleanEx	HS_TECTB.
Genevestigator	Q96PL2.
GermOnline	ENSG00000119913. Homo sapiens.
Family and domain databases
InterPro	IPR001507. ZP_dom. IPR017977. ZP_dom_CS. [Graphical view]
Pfam	PF00100. Zona_pellucida. 1 hit. [Graphical view]
PRINTS	PR00023. ZPELLUCIDA.
SMART	SM00241. ZP. 1 hit. [Graphical view]
PROSITE	PS00682. ZP_1. 1 hit. PS51034. ZP_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	6975.
NextBio	27277.
SOURCE	Search...

Entry information

Entry name

TECTB_HUMAN

Accession

Primary (citable) accession number: Q96PL2
Secondary accession number(s): Q5VW53

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2004
Last sequence update:	December 1, 2001
Last modified:	April 3, 2013
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.