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Q96PL2

- TECTB_HUMAN

UniProt

Q96PL2 - TECTB_HUMAN

Protein

Beta-tectorin

Gene

TECTB

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    One of the major non-collagenous components of the tectorial membrane By similarity. The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals.By similarity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-tectorin
    Gene namesi
    Name:TECTB
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:11721. TECTB.

    Subcellular locationi

    Cell membrane Curated; Lipid-anchorGPI-anchor Curated; Extracellular side Curated. Secretedextracellular spaceextracellular matrix
    Note: Found in the non-collagenous matrix of the tectorial membrane.By similarity

    GO - Cellular componenti

    1. anchored component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell
    3. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Extracellular matrix, Membrane, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36438.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Chaini18 – 305288Beta-tectorinPRO_0000041741Add
    BLAST
    Propeptidei306 – 32924Removed in mature formSequence AnalysisPRO_0000041742Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi80 – 801N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi116 – 1161N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi145 – 1451N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi204 ↔ 264By similarity
    Lipidationi305 – 3051GPI-anchor amidated glycineSequence Analysis

    Post-translational modificationi

    The presence of a hydrophobic C-terminus preceded by a potential cleavage site strongly suggests that tectorins are synthesized as glycosylphosphatidylinositol-linked, membrane-bound precursors. Tectorins are targeted to the apical surface of the inner ear epithelia by the lipid and proteolytically released into the extracellular compartment.

    Keywords - PTMi

    Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

    Proteomic databases

    PaxDbiQ96PL2.
    PRIDEiQ96PL2.

    Expressioni

    Gene expression databases

    BgeeiQ96PL2.
    CleanExiHS_TECTB.
    GenevestigatoriQ96PL2.

    Interactioni

    Subunit structurei

    May form homomeric filament after self-association or heteromeric filament after association with alpha-tectorin.

    Protein-protein interaction databases

    STRINGi9606.ENSP00000358430.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96PL2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini19 – 283265ZPPROSITE-ProRule annotationAdd
    BLAST

    Domaini

    Zona pellucida domain may enable to form filaments.

    Sequence similaritiesi

    Contains 1 ZP domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG44475.
    HOGENOMiHOG000124070.
    HOVERGENiHBG056825.
    InParanoidiQ96PL2.
    OMAiNNCWATP.
    OrthoDBiEOG7060R8.
    PhylomeDBiQ96PL2.
    TreeFamiTF330284.

    Family and domain databases

    InterProiIPR001507. ZP_dom.
    IPR017977. ZP_dom_CS.
    [Graphical view]
    PfamiPF00100. Zona_pellucida. 1 hit.
    [Graphical view]
    PRINTSiPR00023. ZPELLUCIDA.
    SMARTiSM00241. ZP. 1 hit.
    [Graphical view]
    PROSITEiPS00682. ZP_1. 1 hit.
    PS51034. ZP_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q96PL2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVTKAFVLLA IFAEASAKSC APNKADVILV FCYPKTIITK IPECPYGWEV    50
    HQLALGGLCY NGVHEGGYYQ FVIPDLSPKN KSYCGTQSEY KPPIYHFYSH 100
    IVSNDTTVIV KNQPVNYSFS CTYHSTYLVN QAAFDQRVAT VHVKNGSMGT 150
    FESQLSLNFY TNAKFSIKKE APFVLEASEI GSDLFAGVEA KGLSIRFKVV 200
    LNSCWATPSA DFMYPLQWQL INKGCPTDET VLVHENGRDH RATFQFNAFR 250
    FQNIPKLSKV WLHCETFICD SEKLSCPVTC DKRKRLLRDQ TGGVLVVELS 300
    LRSRGFSSLY SFSDVLHHLI MMLGICAVL 329
    Length:329
    Mass (Da):36,956
    Last modified:December 1, 2001 - v1
    Checksum:i0B4D379624F488D0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF312827 mRNA. Translation: AAL12829.1.
    AL391986 Genomic DNA. Translation: CAH73718.1.
    BC113497 mRNA. Translation: AAI13498.1.
    BC113499 mRNA. Translation: AAI13500.1.
    CCDSiCCDS7571.1.
    RefSeqiNP_478129.1. NM_058222.2.
    XP_005270164.1. XM_005270107.1.
    UniGeneiHs.345485.
    Hs.348615.

    Genome annotation databases

    EnsembliENST00000369422; ENSP00000358430; ENSG00000119913.
    GeneIDi6975.
    KEGGihsa:6975.
    UCSCiuc001kzr.1. human.

    Polymorphism databases

    DMDMi48428669.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF312827 mRNA. Translation: AAL12829.1 .
    AL391986 Genomic DNA. Translation: CAH73718.1 .
    BC113497 mRNA. Translation: AAI13498.1 .
    BC113499 mRNA. Translation: AAI13500.1 .
    CCDSi CCDS7571.1.
    RefSeqi NP_478129.1. NM_058222.2.
    XP_005270164.1. XM_005270107.1.
    UniGenei Hs.345485.
    Hs.348615.

    3D structure databases

    ProteinModelPortali Q96PL2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000358430.

    Polymorphism databases

    DMDMi 48428669.

    Proteomic databases

    PaxDbi Q96PL2.
    PRIDEi Q96PL2.

    Protocols and materials databases

    DNASUi 6975.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000369422 ; ENSP00000358430 ; ENSG00000119913 .
    GeneIDi 6975.
    KEGGi hsa:6975.
    UCSCi uc001kzr.1. human.

    Organism-specific databases

    CTDi 6975.
    GeneCardsi GC10P114033.
    HGNCi HGNC:11721. TECTB.
    MIMi 602653. gene.
    neXtProti NX_Q96PL2.
    PharmGKBi PA36438.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG44475.
    HOGENOMi HOG000124070.
    HOVERGENi HBG056825.
    InParanoidi Q96PL2.
    OMAi NNCWATP.
    OrthoDBi EOG7060R8.
    PhylomeDBi Q96PL2.
    TreeFami TF330284.

    Miscellaneous databases

    GeneWikii TECTB.
    GenomeRNAii 6975.
    NextBioi 27277.
    PROi Q96PL2.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q96PL2.
    CleanExi HS_TECTB.
    Genevestigatori Q96PL2.

    Family and domain databases

    InterProi IPR001507. ZP_dom.
    IPR017977. ZP_dom_CS.
    [Graphical view ]
    Pfami PF00100. Zona_pellucida. 1 hit.
    [Graphical view ]
    PRINTSi PR00023. ZPELLUCIDA.
    SMARTi SM00241. ZP. 1 hit.
    [Graphical view ]
    PROSITEi PS00682. ZP_1. 1 hit.
    PS51034. ZP_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and identification of human TECTB."
      Xia J.H., Zhang H.L., Deng H., Lu C.Y., Pang Q.
      Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiTECTB_HUMAN
    AccessioniPrimary (citable) accession number: Q96PL2
    Secondary accession number(s): Q5VW53
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2004
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3