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Protein

Secretoglobin family 3A member 2

Gene

SCGB3A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-3000480. Scavenging by Class A Receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Secretoglobin family 3A member 2
Alternative name(s):
Pneumo secretory protein 1
Short name:
PnSP-1
Uteroglobin-related protein 1
Gene namesi
Name:SCGB3A2
Synonyms:PNSP1, UGRP1
ORF Names:UNQ566/PRO1128
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:18391. SCGB3A2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

MalaCardsiSCGB3A2.
PharmGKBiPA34995.

Polymorphism and mutation databases

BioMutaiSCGB3A2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 9372Secretoglobin family 3A member 2PRO_0000036381Add
BLAST

Proteomic databases

PaxDbiQ96PL1.
PeptideAtlasiQ96PL1.
PRIDEiQ96PL1.

PTM databases

iPTMnetiQ96PL1.
PhosphoSiteiQ96PL1.

Expressioni

Tissue specificityi

Highly expressed in lung.

Gene expression databases

BgeeiQ96PL1.
CleanExiHS_SCGB3A2.
ExpressionAtlasiQ96PL1. baseline and differential.
GenevisibleiQ96PL1. HS.

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

BioGridi125562. 1 interaction.
STRINGi9606.ENSP00000296694.

Structurei

3D structure databases

ProteinModelPortaliQ96PL1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the secretoglobin family. UGRP subfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J1Y3. Eukaryota.
ENOG4111402. LUCA.
GeneTreeiENSGT00420000029848.
HOGENOMiHOG000128185.
HOVERGENiHBG079305.
InParanoidiQ96PL1.
OMAiICSYSAT.
PhylomeDBiQ96PL1.
TreeFamiTF336928.

Family and domain databases

InterProiIPR016126. Secretoglobin.
[Graphical view]
PfamiPF01099. Uteroglobin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96PL1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLVTIFLLV TISLCSYSAT AFLINKVPLP VDKLAPLPLD NILPFMDPLK
60 70 80 90
LLLKTLGISV EHLVEGLRKC VNELGPEASE AVKKLLEALS HLV
Length:93
Mass (Da):10,161
Last modified:December 1, 2001 - v1
Checksum:iFBD4BFAC2BF33718
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti33 – 331K → N in a breast cancer sample; somatic mutation. 1 Publication
VAR_036185

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF313455 mRNA. Translation: AAL26215.1.
AF439544 Genomic DNA. Translation: AAQ04559.1.
AF439545 mRNA. Translation: AAQ04560.1.
AY358979 mRNA. Translation: AAQ89338.1.
BC024232 mRNA. Translation: AAH24232.1.
CCDSiCCDS4287.1.
RefSeqiNP_473364.1. NM_054023.4.
UniGeneiHs.483765.

Genome annotation databases

EnsembliENST00000296694; ENSP00000296694; ENSG00000164265.
GeneIDi117156.
KEGGihsa:117156.
UCSCiuc003lot.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF313455 mRNA. Translation: AAL26215.1.
AF439544 Genomic DNA. Translation: AAQ04559.1.
AF439545 mRNA. Translation: AAQ04560.1.
AY358979 mRNA. Translation: AAQ89338.1.
BC024232 mRNA. Translation: AAH24232.1.
CCDSiCCDS4287.1.
RefSeqiNP_473364.1. NM_054023.4.
UniGeneiHs.483765.

3D structure databases

ProteinModelPortaliQ96PL1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125562. 1 interaction.
STRINGi9606.ENSP00000296694.

PTM databases

iPTMnetiQ96PL1.
PhosphoSiteiQ96PL1.

Polymorphism and mutation databases

BioMutaiSCGB3A2.

Proteomic databases

PaxDbiQ96PL1.
PeptideAtlasiQ96PL1.
PRIDEiQ96PL1.

Protocols and materials databases

DNASUi117156.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296694; ENSP00000296694; ENSG00000164265.
GeneIDi117156.
KEGGihsa:117156.
UCSCiuc003lot.3. human.

Organism-specific databases

CTDi117156.
GeneCardsiSCGB3A2.
HGNCiHGNC:18391. SCGB3A2.
MalaCardsiSCGB3A2.
MIMi606531. gene.
neXtProtiNX_Q96PL1.
PharmGKBiPA34995.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J1Y3. Eukaryota.
ENOG4111402. LUCA.
GeneTreeiENSGT00420000029848.
HOGENOMiHOG000128185.
HOVERGENiHBG079305.
InParanoidiQ96PL1.
OMAiICSYSAT.
PhylomeDBiQ96PL1.
TreeFamiTF336928.

Enzyme and pathway databases

ReactomeiR-HSA-3000480. Scavenging by Class A Receptors.

Miscellaneous databases

GeneWikiiSCGB3A2.
GenomeRNAii117156.
PROiQ96PL1.
SOURCEiSearch...

Gene expression databases

BgeeiQ96PL1.
CleanExiHS_SCGB3A2.
ExpressionAtlasiQ96PL1. baseline and differential.
GenevisibleiQ96PL1. HS.

Family and domain databases

InterProiIPR016126. Secretoglobin.
[Graphical view]
PfamiPF01099. Uteroglobin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "UGRP1, a uteroglobin/Clara cell secretory protein-related protein, is a novel lung-enriched downstream target gene for the T/EBP/NKX2.1 homeodomain transcription factor."
    Niimi T., Keck-Waggoner C.L., Popescu N.C., Zhou Y., Levitt R.C., Kimura S.
    Mol. Endocrinol. 15:2021-2036(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Molecular cloning of PnSP-1, a protein of the respiratory tract with potential association to atopy."
    Clippe A., Laing I.A., LeSouef P.N., Bernard A., Knoops B.
    Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  5. Cited for: VARIANT [LARGE SCALE ANALYSIS] ASN-33.

Entry informationi

Entry nameiSG3A2_HUMAN
AccessioniPrimary (citable) accession number: Q96PL1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: December 1, 2001
Last modified: June 8, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.