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Q96PJ5 (FCRL4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fc receptor-like protein 4

Short name=FcR-like protein 4
Short name=FcRL4
Alternative name(s):
Fc receptor homolog 4
Short name=FcRH4
IFGP family protein 2
Short name=hIFGP2
Immune receptor translocation-associated protein 1
CD_antigen=CD307d
Gene names
Name:FCRL4
Synonyms:FCRH4, IFGP2, IRTA1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length515 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May function as an inhibitor of the B-cell receptor signaling. May function in the B-cell-mediated immune response. Ref.10

Subcellular location

Cell membrane; Single-pass type I membrane protein Ref.12 Ref.13.

Tissue specificity

Specifically expressed by memory and monocytoid B-cells which populate spleen and lymph nodes. Preferentially expressed in memory B-cells associated with mucosal tissue (at protein level). Ref.1 Ref.7 Ref.8 Ref.11 Ref.12 Ref.13

Post-translational modification

Phosphorylated on cytoplasmic tyrosines upon activation. Ref.10

Involvement in disease

A chromosomal aberration involving FCRL4 is found in non-Hodgkin lymphoma (NHG). Translocation t(1;1)(p36.3; q21.1-2).

A chromosomal aberration involving FCRL4 is found in multiple myeloma (MM). Translocation t(1;14)(q21;q32) that forms a FCRL4-IGHA1 fusion protein.

Sequence similarities

Contains 4 Ig-like C2-type (immunoglobulin-like) domains.

Binary interactions

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q96PJ5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q96PJ5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     454-515: VHPKKGDLVY...GKISSKDEES → GEDSLLGSCS...VEMMLRKRHL
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 515496Fc receptor-like protein 4
PRO_0000331642

Regions

Topological domain20 – 387368Extracellular Potential
Transmembrane388 – 40821Helical; Potential
Topological domain409 – 515107Cytoplasmic Potential
Domain23 – 9775Ig-like C2-type 1
Domain102 – 18382Ig-like C2-type 2
Domain193 – 27179Ig-like C2-type 3
Domain275 – 374100Ig-like C2-type 4
Motif449 – 4546ITIM motif 1
Motif461 – 4666ITIM motif 2
Motif491 – 4966ITIM motif 3

Sites

Site17 – 182Breakpoint for insertion to form FCRL4-IGHA1 fusion protein

Amino acid modifications

Glycosylation3741N-linked (GlcNAc...) Potential
Disulfide bond44 ↔ 85 By similarity
Disulfide bond123 ↔ 167 By similarity
Disulfide bond212 ↔ 261 By similarity
Disulfide bond310 ↔ 359 By similarity

Natural variations

Alternative sequence454 – 51562VHPKK…KDEES → GEDSLLGSCSWPQPWKDNAL SALGNAPGLPKVSQIQIFPD IMCPRRVEMMLRKRHL in isoform 2.
VSP_033310
Natural variant601R → Q.
Corresponds to variant rs11582663 [ dbSNP | Ensembl ].
VAR_042929
Natural variant2551N → S.
Corresponds to variant rs4561035 [ dbSNP | Ensembl ].
VAR_042930
Natural variant4571K → R.
Corresponds to variant rs2039401 [ dbSNP | Ensembl ].
VAR_042931
Natural variant4931Y → C.
Corresponds to variant rs3811028 [ dbSNP | Ensembl ].
VAR_042932

Experimental info

Mutagenesis4511Y → F: No effect on function, phosphorylation and interaction with PTPN6 and PTPN11. Ref.10
Mutagenesis4631Y → F: Loss of function, phosphorylation and interaction with PTPN6 and PTPN11. Ref.10
Mutagenesis4931Y → F: Loss of interaction with PTPN6 and PTPN11 and partial loss of function and phosphorylation. Ref.10
Sequence conflict1791S → L in AAK93970. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: F3B7AD14FB1B449A

FASTA51557,224
        10         20         30         40         50         60 
MLLWASLLAF APVCGQSAAA HKPVISVHPP WTTFFKGERV TLTCNGFQFY ATEKTTWYHR 

        70         80         90        100        110        120 
HYWGEKLTLT PGNTLEVRES GLYRCQARGS PRSNPVRLLF SSDSLILQAP YSVFEGDTLV 

       130        140        150        160        170        180 
LRCHRRRKEK LTAVKYTWNG NILSISNKSW DLLIPQASSN NNGNYRCIGY GDENDVFRSN 

       190        200        210        220        230        240 
FKIIKIQELF PHPELKATDS QPTEGNSVNL SCETQLPPER SDTPLHFNFF RDGEVILSDW 

       250        260        270        280        290        300 
STYPELQLPT VWRENSGSYW CGAETVRGNI HKHSPSLQIH VQRIPVSGVL LETQPSGGQA 

       310        320        330        340        350        360 
VEGEMLVLVC SVAEGTGDTT FSWHREDMQE SLGRKTQRSL RAELELPAIR QSHAGGYYCT 

       370        380        390        400        410        420 
ADNSYGPVQS MVLNVTVRET PGNRDGLVAA GATGGLLSAL LLAVALLFHC WRRRKSGVGF 

       430        440        450        460        470        480 
LGDETRLPPA PGPGESSHSI CPAQVELQSL YVDVHPKKGD LVYSEIQTTQ LGEEEEANTS 

       490        500        510 
RTLLEDKDVS VVYSEVKTQH PDNSAGKISS KDEES 

« Hide

Isoform 2 [UniParc].

Checksum: 2810BA15A2BA5405
Show »

FASTA50956,636

References

« Hide 'large scale' references
[1]"IRTA1 and IRTA2, novel immunoglobulin superfamily receptors expressed in B cells and involved in chromosome 1q21 abnormalities in B cell malignancy."
Hatzivassiliou G., Miller I., Takizawa J., Palanisamy N., Rao P.H., Iida S., Tagawa S., Taniwaki M., Russo J., Neri A., Cattoretti G., Clynes R., Mendelsohn C., Chaganti R.S.K., Dalla-Favera R.
Immunity 14:277-289(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, CHROMOSOMAL TRANSLOCATION WITH IGHA1.
Tissue: Spleen.
[2]"Identification of a family of Fc receptor homologs with preferential B cell expression."
Davis R.S., Wang Y.-H., Kubagawa H., Cooper M.D.
Proc. Natl. Acad. Sci. U.S.A. 98:9772-9777(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Lymph node.
[3]"A family of highly diverse human and mouse genes structurally links leukocyte FcR, gp42 and PECAM-1."
Guselnikov S.V., Ershova S.A., Mechetina L.V., Najakshin A.M., Volkova O.Y., Alabyev B.Y., Taranin A.V.
Immunogenetics 54:87-95(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [MRNA] OF 88-515 (ISOFORM 2).
Tissue: Tonsil.
[4]Livingston R.J., Shaffer T., McFarland I., Nguyen C.P., Stanaway I.B., Rajkumar N., Johnson E.J., da Ponte S.H., Willa H., Ahearn M.O., Bertucci C., Acklestad J., Carroll A., Swanson J., Gildersleeve H.I., Nickerson D.A.
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[7]"IRTAs: a new family of immunoglobulin-like receptors differentially expressed in B cells."
Miller I., Hatzivassiliou G., Cattoretti G., Mendelsohn C., Dalla-Favera R.
Blood 99:2662-2669(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION, TISSUE SPECIFICITY.
[8]"Expression of the IRTA1 receptor identifies intraepithelial and subepithelial marginal zone B cells of the mucosa-associated lymphoid tissue (MALT)."
Falini B., Tiacci E., Pucciarini A., Bigerna B., Kurth J., Hatzivassiliou G., Droetto S., Galletti B.V., Gambacorta M., Orazi A., Pasqualucci L., Miller I., Kueppers R., Dalla-Favera R., Cattoretti G.
Blood 102:3684-3692(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[9]"Characterization of the recurrent translocation t(1;1)(p36.3;q21.1-2) in non-Hodgkin lymphoma by multicolor banding and fluorescence in situ hybridization analysis."
Lestou V.S., Ludkovski O., Connors J.M., Gascoyne R.D., Lam W.L., Horsman D.E.
Genes Chromosomes Cancer 36:375-381(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: CHROMOSOMAL TRANSLOCATION.
[10]"The inhibitory potential of Fc receptor homolog 4 on memory B cells."
Ehrhardt G.R.A., Davis R.S., Hsu J.T., Leu C.-M., Ehrhardt A., Cooper M.D.
Proc. Natl. Acad. Sci. U.S.A. 100:13489-13494(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, PHOSPHORYLATION, MUTAGENESIS OF TYR-451; TYR-463 AND TYR-493, INTERACTION WITH PTPN6 AND PTPN11.
[11]"T-bet-positive and IRTA1-positive monocytoid B cells differ from marginal zone B cells and epithelial-associated B cells in their antigen profile and topographical distribution."
Joehrens K., Shimizu Y., Anagnostopoulos I., Schiffmann S., Tiacci E., Falini B., Stein H.
Haematologica 90:1070-1077(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[12]"Expression of the immunoregulatory molecule FcRH4 defines a distinctive tissue-based population of memory B cells."
Ehrhardt G.R.A., Hsu J.T., Gartland L., Leu C.-M., Zhang S., Davis R.S., Cooper M.D.
J. Exp. Med. 202:783-791(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[13]"Expression pattern of the human FcRH/IRTA receptors in normal tissue and in B-chronic lymphocytic leukemia."
Polson A.G., Zheng B., Elkins K., Chang W., Du C., Dowd P., Yen L., Tan C., Hongo J.-A., Koeppen H., Ebens A.
Int. Immunol. 18:1363-1373(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF343659 mRNA. No translation available.
AF397452 mRNA. Translation: AAK93970.1.
AF329490 mRNA. Translation: AAL23900.1.
AF329492 mRNA. Translation: AAL23902.1.
EF064731 Genomic DNA. Translation: ABK41914.1.
CH471121 Genomic DNA. Translation: EAW52883.1.
BC125173 mRNA. Translation: AAI25174.1.
BC125174 mRNA. Translation: AAI25175.1.
CCDSCCDS1166.1. [Q96PJ5-1]
RefSeqNP_112572.1. NM_031282.2. [Q96PJ5-1]
UniGeneHs.120260.

3D structure databases

ProteinModelPortalQ96PJ5.
SMRQ96PJ5. Positions 22-381.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid123641. 2 interactions.
IntActQ96PJ5. 2 interactions.
STRING9606.ENSP00000271532.

Protein family/group databases

MEROPSI43.001.

PTM databases

PhosphoSiteQ96PJ5.

Polymorphism databases

DMDM74761029.

Proteomic databases

PaxDbQ96PJ5.
PRIDEQ96PJ5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000271532; ENSP00000271532; ENSG00000163518. [Q96PJ5-1]
GeneID83417.
KEGGhsa:83417.
UCSCuc001fqw.3. human. [Q96PJ5-1]

Organism-specific databases

CTD83417.
GeneCardsGC01M157543.
HGNCHGNC:18507. FCRL4.
HPAHPA054030.
MIM605876. gene.
neXtProtNX_Q96PJ5.
PharmGKBPA142671768.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG149358.
HOGENOMHOG000036945.
InParanoidQ96PJ5.
OMAWCGAETV.
OrthoDBEOG7BP81V.
PhylomeDBQ96PJ5.
TreeFamTF351107.

Gene expression databases

BgeeQ96PJ5.
CleanExHS_FCRL4.
GenevestigatorQ96PJ5.

Family and domain databases

Gene3D2.60.40.10. 4 hits.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
SMARTSM00409. IG. 3 hits.
SM00408. IGc2. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiFCRL4.
GenomeRNAi83417.
NextBio72310.
PROQ96PJ5.
SOURCESearch...

Entry information

Entry nameFCRL4_HUMAN
AccessionPrimary (citable) accession number: Q96PJ5
Secondary accession number(s): Q96PJ3, Q96RE0
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries