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Protein

Fc receptor-like protein 4

Gene

FCRL4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May function as an inhibitor of the B-cell receptor signaling. May function in the B-cell-mediated immune response.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei17 – 18Breakpoint for insertion to form FCRL4-IGHA1 fusion protein2

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Adaptive immunity, Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Fc receptor-like protein 4
Short name:
FcR-like protein 4
Short name:
FcRL4
Alternative name(s):
Fc receptor homolog 4
Short name:
FcRH4
IFGP family protein 2
Short name:
hIFGP2
Immune receptor translocation-associated protein 1
CD_antigen: CD307d
Gene namesi
Name:FCRL4
Synonyms:FCRH4, IFGP2, IRTA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:18507. FCRL4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 387ExtracellularSequence analysisAdd BLAST368
Transmembranei388 – 408HelicalSequence analysisAdd BLAST21
Topological domaini409 – 515CytoplasmicSequence analysisAdd BLAST107

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving FCRL4 is found in non-Hodgkin lymphoma (NHG). Translocation t(1;1)(p36.3; q21.1-2).

A chromosomal aberration involving FCRL4 is found in multiple myeloma (MM). Translocation t(1;14)(q21;q32) that forms a FCRL4-IGHA1 fusion protein.

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi451Y → F: No effect on function, phosphorylation and interaction with PTPN6 and PTPN11. 1 Publication1
Mutagenesisi463Y → F: Loss of function, phosphorylation and interaction with PTPN6 and PTPN11. 1 Publication1
Mutagenesisi493Y → F: Loss of interaction with PTPN6 and PTPN11 and partial loss of function and phosphorylation. 1 Publication1

Organism-specific databases

DisGeNETi83417.
OpenTargetsiENSG00000163518.
PharmGKBiPA142671768.

Polymorphism and mutation databases

BioMutaiFCRL4.
DMDMi74761029.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000033164220 – 515Fc receptor-like protein 4Add BLAST496

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi44 ↔ 85PROSITE-ProRule annotation
Disulfide bondi123 ↔ 167PROSITE-ProRule annotation
Disulfide bondi212 ↔ 261PROSITE-ProRule annotation
Disulfide bondi310 ↔ 359PROSITE-ProRule annotation
Glycosylationi374N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Phosphorylated on cytoplasmic tyrosines upon activation.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ96PJ5.
PRIDEiQ96PJ5.

PTM databases

iPTMnetiQ96PJ5.
PhosphoSitePlusiQ96PJ5.

Expressioni

Tissue specificityi

Specifically expressed by memory and monocytoid B-cells which populate spleen and lymph nodes. Preferentially expressed in memory B-cells associated with mucosal tissue (at protein level).6 Publications

Gene expression databases

BgeeiENSG00000163518.
CleanExiHS_FCRL4.
GenevisibleiQ96PJ5. HS.

Organism-specific databases

HPAiHPA054030.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TFF1P041553EBI-4314687,EBI-743871
TFF2Q034033EBI-4314687,EBI-4314702

Protein-protein interaction databases

BioGridi123641. 6 interactors.
IntActiQ96PJ5. 3 interactors.
STRINGi9606.ENSP00000271532.

Structurei

3D structure databases

ProteinModelPortaliQ96PJ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 97Ig-like C2-type 1Add BLAST75
Domaini102 – 183Ig-like C2-type 2Add BLAST82
Domaini193 – 271Ig-like C2-type 3Add BLAST79
Domaini275 – 374Ig-like C2-type 4Add BLAST100

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi449 – 454ITIM motif 16
Motifi461 – 466ITIM motif 26
Motifi491 – 496ITIM motif 36

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IXWJ. Eukaryota.
ENOG410Z11U. LUCA.
GeneTreeiENSGT00760000119130.
HOGENOMiHOG000036945.
InParanoidiQ96PJ5.
KOiK06727.
OMAiWCGAETV.
OrthoDBiEOG091G03OP.
PhylomeDBiQ96PJ5.
TreeFamiTF351107.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF00047. ig. 1 hit.
PF13895. Ig_2. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 4 hits.
SM00408. IGc2. 4 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
PROSITEiPS50835. IG_LIKE. 4 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96PJ5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLLWASLLAF APVCGQSAAA HKPVISVHPP WTTFFKGERV TLTCNGFQFY
60 70 80 90 100
ATEKTTWYHR HYWGEKLTLT PGNTLEVRES GLYRCQARGS PRSNPVRLLF
110 120 130 140 150
SSDSLILQAP YSVFEGDTLV LRCHRRRKEK LTAVKYTWNG NILSISNKSW
160 170 180 190 200
DLLIPQASSN NNGNYRCIGY GDENDVFRSN FKIIKIQELF PHPELKATDS
210 220 230 240 250
QPTEGNSVNL SCETQLPPER SDTPLHFNFF RDGEVILSDW STYPELQLPT
260 270 280 290 300
VWRENSGSYW CGAETVRGNI HKHSPSLQIH VQRIPVSGVL LETQPSGGQA
310 320 330 340 350
VEGEMLVLVC SVAEGTGDTT FSWHREDMQE SLGRKTQRSL RAELELPAIR
360 370 380 390 400
QSHAGGYYCT ADNSYGPVQS MVLNVTVRET PGNRDGLVAA GATGGLLSAL
410 420 430 440 450
LLAVALLFHC WRRRKSGVGF LGDETRLPPA PGPGESSHSI CPAQVELQSL
460 470 480 490 500
YVDVHPKKGD LVYSEIQTTQ LGEEEEANTS RTLLEDKDVS VVYSEVKTQH
510
PDNSAGKISS KDEES
Length:515
Mass (Da):57,224
Last modified:December 1, 2001 - v1
Checksum:iF3B7AD14FB1B449A
GO
Isoform 2 (identifier: Q96PJ5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     454-515: VHPKKGDLVY...GKISSKDEES → GEDSLLGSCS...VEMMLRKRHL

Note: No experimental confirmation available.
Show »
Length:509
Mass (Da):56,636
Checksum:i2810BA15A2BA5405
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti179S → L in AAK93970 (PubMed:11493702).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04292960R → Q.Corresponds to variant rs11582663dbSNPEnsembl.1
Natural variantiVAR_042930255N → S.Corresponds to variant rs4561035dbSNPEnsembl.1
Natural variantiVAR_042931457K → R.Corresponds to variant rs2039401dbSNPEnsembl.1
Natural variantiVAR_042932493Y → C.Corresponds to variant rs3811028dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_033310454 – 515VHPKK…KDEES → GEDSLLGSCSWPQPWKDNAL SALGNAPGLPKVSQIQIFPD IMCPRRVEMMLRKRHL in isoform 2. 1 PublicationAdd BLAST62

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF343659 mRNA. No translation available.
AF397452 mRNA. Translation: AAK93970.1.
AF329490 mRNA. Translation: AAL23900.1.
AF329492 mRNA. Translation: AAL23902.1.
EF064731 Genomic DNA. Translation: ABK41914.1.
CH471121 Genomic DNA. Translation: EAW52883.1.
BC125173 mRNA. Translation: AAI25174.1.
BC125174 mRNA. Translation: AAI25175.1.
CCDSiCCDS1166.1. [Q96PJ5-1]
RefSeqiNP_112572.1. NM_031282.2. [Q96PJ5-1]
UniGeneiHs.120260.

Genome annotation databases

EnsembliENST00000271532; ENSP00000271532; ENSG00000163518. [Q96PJ5-1]
GeneIDi83417.
KEGGihsa:83417.
UCSCiuc001fqw.3. human. [Q96PJ5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF343659 mRNA. No translation available.
AF397452 mRNA. Translation: AAK93970.1.
AF329490 mRNA. Translation: AAL23900.1.
AF329492 mRNA. Translation: AAL23902.1.
EF064731 Genomic DNA. Translation: ABK41914.1.
CH471121 Genomic DNA. Translation: EAW52883.1.
BC125173 mRNA. Translation: AAI25174.1.
BC125174 mRNA. Translation: AAI25175.1.
CCDSiCCDS1166.1. [Q96PJ5-1]
RefSeqiNP_112572.1. NM_031282.2. [Q96PJ5-1]
UniGeneiHs.120260.

3D structure databases

ProteinModelPortaliQ96PJ5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123641. 6 interactors.
IntActiQ96PJ5. 3 interactors.
STRINGi9606.ENSP00000271532.

PTM databases

iPTMnetiQ96PJ5.
PhosphoSitePlusiQ96PJ5.

Polymorphism and mutation databases

BioMutaiFCRL4.
DMDMi74761029.

Proteomic databases

PaxDbiQ96PJ5.
PRIDEiQ96PJ5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000271532; ENSP00000271532; ENSG00000163518. [Q96PJ5-1]
GeneIDi83417.
KEGGihsa:83417.
UCSCiuc001fqw.3. human. [Q96PJ5-1]

Organism-specific databases

CTDi83417.
DisGeNETi83417.
GeneCardsiFCRL4.
HGNCiHGNC:18507. FCRL4.
HPAiHPA054030.
MIMi605876. gene.
neXtProtiNX_Q96PJ5.
OpenTargetsiENSG00000163518.
PharmGKBiPA142671768.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXWJ. Eukaryota.
ENOG410Z11U. LUCA.
GeneTreeiENSGT00760000119130.
HOGENOMiHOG000036945.
InParanoidiQ96PJ5.
KOiK06727.
OMAiWCGAETV.
OrthoDBiEOG091G03OP.
PhylomeDBiQ96PJ5.
TreeFamiTF351107.

Miscellaneous databases

ChiTaRSiFCRL4. human.
GeneWikiiFCRL4.
GenomeRNAii83417.
PROiQ96PJ5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163518.
CleanExiHS_FCRL4.
GenevisibleiQ96PJ5. HS.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF00047. ig. 1 hit.
PF13895. Ig_2. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 4 hits.
SM00408. IGc2. 4 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
PROSITEiPS50835. IG_LIKE. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFCRL4_HUMAN
AccessioniPrimary (citable) accession number: Q96PJ5
Secondary accession number(s): Q96PJ3, Q96RE0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.