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Q96PJ5

- FCRL4_HUMAN

UniProt

Q96PJ5 - FCRL4_HUMAN

Protein

Fc receptor-like protein 4

Gene

FCRL4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    May function as an inhibitor of the B-cell receptor signaling. May function in the B-cell-mediated immune response.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei17 – 182Breakpoint for insertion to form FCRL4-IGHA1 fusion protein

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. immune system process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Adaptive immunity, Immunity

    Protein family/group databases

    MEROPSiI43.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fc receptor-like protein 4
    Short name:
    FcR-like protein 4
    Short name:
    FcRL4
    Alternative name(s):
    Fc receptor homolog 4
    Short name:
    FcRH4
    IFGP family protein 2
    Short name:
    hIFGP2
    Immune receptor translocation-associated protein 1
    CD_antigen: CD307d
    Gene namesi
    Name:FCRL4
    Synonyms:FCRH4, IFGP2, IRTA1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:18507. FCRL4.

    Subcellular locationi

    Cell membrane 2 Publications; Single-pass type I membrane protein 2 Publications

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    A chromosomal aberration involving FCRL4 is found in non-Hodgkin lymphoma (NHG). Translocation t(1;1)(p36.3; q21.1-2).
    A chromosomal aberration involving FCRL4 is found in multiple myeloma (MM). Translocation t(1;14)(q21;q32) that forms a FCRL4-IGHA1 fusion protein.

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi451 – 4511Y → F: No effect on function, phosphorylation and interaction with PTPN6 and PTPN11. 1 Publication
    Mutagenesisi463 – 4631Y → F: Loss of function, phosphorylation and interaction with PTPN6 and PTPN11. 1 Publication
    Mutagenesisi493 – 4931Y → F: Loss of interaction with PTPN6 and PTPN11 and partial loss of function and phosphorylation. 1 Publication

    Organism-specific databases

    PharmGKBiPA142671768.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 515496Fc receptor-like protein 4PRO_0000331642Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi44 ↔ 85PROSITE-ProRule annotation
    Disulfide bondi123 ↔ 167PROSITE-ProRule annotation
    Disulfide bondi212 ↔ 261PROSITE-ProRule annotation
    Disulfide bondi310 ↔ 359PROSITE-ProRule annotation
    Glycosylationi374 – 3741N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Phosphorylated on cytoplasmic tyrosines upon activation.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiQ96PJ5.
    PRIDEiQ96PJ5.

    PTM databases

    PhosphoSiteiQ96PJ5.

    Expressioni

    Tissue specificityi

    Specifically expressed by memory and monocytoid B-cells which populate spleen and lymph nodes. Preferentially expressed in memory B-cells associated with mucosal tissue (at protein level).6 Publications

    Gene expression databases

    BgeeiQ96PJ5.
    CleanExiHS_FCRL4.
    GenevestigatoriQ96PJ5.

    Organism-specific databases

    HPAiHPA054030.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    TFF1P041553EBI-4314687,EBI-743871
    TFF2Q034033EBI-4314687,EBI-4314702

    Protein-protein interaction databases

    BioGridi123641. 2 interactions.
    IntActiQ96PJ5. 2 interactions.
    STRINGi9606.ENSP00000271532.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96PJ5.
    SMRiQ96PJ5. Positions 22-381.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini20 – 387368ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini409 – 515107CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei388 – 40821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini23 – 9775Ig-like C2-type 1Add
    BLAST
    Domaini102 – 18382Ig-like C2-type 2Add
    BLAST
    Domaini193 – 27179Ig-like C2-type 3Add
    BLAST
    Domaini275 – 374100Ig-like C2-type 4Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi449 – 4546ITIM motif 1
    Motifi461 – 4666ITIM motif 2
    Motifi491 – 4966ITIM motif 3

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG149358.
    HOGENOMiHOG000036945.
    InParanoidiQ96PJ5.
    OMAiWCGAETV.
    OrthoDBiEOG7BP81V.
    PhylomeDBiQ96PJ5.
    TreeFamiTF351107.

    Family and domain databases

    Gene3Di2.60.40.10. 4 hits.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    [Graphical view]
    SMARTiSM00409. IG. 3 hits.
    SM00408. IGc2. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 4 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96PJ5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLLWASLLAF APVCGQSAAA HKPVISVHPP WTTFFKGERV TLTCNGFQFY    50
    ATEKTTWYHR HYWGEKLTLT PGNTLEVRES GLYRCQARGS PRSNPVRLLF 100
    SSDSLILQAP YSVFEGDTLV LRCHRRRKEK LTAVKYTWNG NILSISNKSW 150
    DLLIPQASSN NNGNYRCIGY GDENDVFRSN FKIIKIQELF PHPELKATDS 200
    QPTEGNSVNL SCETQLPPER SDTPLHFNFF RDGEVILSDW STYPELQLPT 250
    VWRENSGSYW CGAETVRGNI HKHSPSLQIH VQRIPVSGVL LETQPSGGQA 300
    VEGEMLVLVC SVAEGTGDTT FSWHREDMQE SLGRKTQRSL RAELELPAIR 350
    QSHAGGYYCT ADNSYGPVQS MVLNVTVRET PGNRDGLVAA GATGGLLSAL 400
    LLAVALLFHC WRRRKSGVGF LGDETRLPPA PGPGESSHSI CPAQVELQSL 450
    YVDVHPKKGD LVYSEIQTTQ LGEEEEANTS RTLLEDKDVS VVYSEVKTQH 500
    PDNSAGKISS KDEES 515
    Length:515
    Mass (Da):57,224
    Last modified:December 1, 2001 - v1
    Checksum:iF3B7AD14FB1B449A
    GO
    Isoform 2 (identifier: Q96PJ5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         454-515: VHPKKGDLVY...GKISSKDEES → GEDSLLGSCS...VEMMLRKRHL

    Note: No experimental confirmation available.

    Show »
    Length:509
    Mass (Da):56,636
    Checksum:i2810BA15A2BA5405
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti179 – 1791S → L in AAK93970. (PubMed:11493702)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti60 – 601R → Q.
    Corresponds to variant rs11582663 [ dbSNP | Ensembl ].
    VAR_042929
    Natural varianti255 – 2551N → S.
    Corresponds to variant rs4561035 [ dbSNP | Ensembl ].
    VAR_042930
    Natural varianti457 – 4571K → R.
    Corresponds to variant rs2039401 [ dbSNP | Ensembl ].
    VAR_042931
    Natural varianti493 – 4931Y → C.
    Corresponds to variant rs3811028 [ dbSNP | Ensembl ].
    VAR_042932

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei454 – 51562VHPKK…KDEES → GEDSLLGSCSWPQPWKDNAL SALGNAPGLPKVSQIQIFPD IMCPRRVEMMLRKRHL in isoform 2. 1 PublicationVSP_033310Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF343659 mRNA. No translation available.
    AF397452 mRNA. Translation: AAK93970.1.
    AF329490 mRNA. Translation: AAL23900.1.
    AF329492 mRNA. Translation: AAL23902.1.
    EF064731 Genomic DNA. Translation: ABK41914.1.
    CH471121 Genomic DNA. Translation: EAW52883.1.
    BC125173 mRNA. Translation: AAI25174.1.
    BC125174 mRNA. Translation: AAI25175.1.
    CCDSiCCDS1166.1. [Q96PJ5-1]
    RefSeqiNP_112572.1. NM_031282.2. [Q96PJ5-1]
    UniGeneiHs.120260.

    Genome annotation databases

    EnsembliENST00000271532; ENSP00000271532; ENSG00000163518. [Q96PJ5-1]
    GeneIDi83417.
    KEGGihsa:83417.
    UCSCiuc001fqw.3. human. [Q96PJ5-1]

    Polymorphism databases

    DMDMi74761029.

    Keywords - Coding sequence diversityi

    Alternative splicing, Chromosomal rearrangement, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF343659 mRNA. No translation available.
    AF397452 mRNA. Translation: AAK93970.1 .
    AF329490 mRNA. Translation: AAL23900.1 .
    AF329492 mRNA. Translation: AAL23902.1 .
    EF064731 Genomic DNA. Translation: ABK41914.1 .
    CH471121 Genomic DNA. Translation: EAW52883.1 .
    BC125173 mRNA. Translation: AAI25174.1 .
    BC125174 mRNA. Translation: AAI25175.1 .
    CCDSi CCDS1166.1. [Q96PJ5-1 ]
    RefSeqi NP_112572.1. NM_031282.2. [Q96PJ5-1 ]
    UniGenei Hs.120260.

    3D structure databases

    ProteinModelPortali Q96PJ5.
    SMRi Q96PJ5. Positions 22-381.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123641. 2 interactions.
    IntActi Q96PJ5. 2 interactions.
    STRINGi 9606.ENSP00000271532.

    Protein family/group databases

    MEROPSi I43.001.

    PTM databases

    PhosphoSitei Q96PJ5.

    Polymorphism databases

    DMDMi 74761029.

    Proteomic databases

    PaxDbi Q96PJ5.
    PRIDEi Q96PJ5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000271532 ; ENSP00000271532 ; ENSG00000163518 . [Q96PJ5-1 ]
    GeneIDi 83417.
    KEGGi hsa:83417.
    UCSCi uc001fqw.3. human. [Q96PJ5-1 ]

    Organism-specific databases

    CTDi 83417.
    GeneCardsi GC01M157543.
    HGNCi HGNC:18507. FCRL4.
    HPAi HPA054030.
    MIMi 605876. gene.
    neXtProti NX_Q96PJ5.
    PharmGKBi PA142671768.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG149358.
    HOGENOMi HOG000036945.
    InParanoidi Q96PJ5.
    OMAi WCGAETV.
    OrthoDBi EOG7BP81V.
    PhylomeDBi Q96PJ5.
    TreeFami TF351107.

    Miscellaneous databases

    GeneWikii FCRL4.
    GenomeRNAii 83417.
    NextBioi 72310.
    PROi Q96PJ5.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q96PJ5.
    CleanExi HS_FCRL4.
    Genevestigatori Q96PJ5.

    Family and domain databases

    Gene3Di 2.60.40.10. 4 hits.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    [Graphical view ]
    SMARTi SM00409. IG. 3 hits.
    SM00408. IGc2. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "IRTA1 and IRTA2, novel immunoglobulin superfamily receptors expressed in B cells and involved in chromosome 1q21 abnormalities in B cell malignancy."
      Hatzivassiliou G., Miller I., Takizawa J., Palanisamy N., Rao P.H., Iida S., Tagawa S., Taniwaki M., Russo J., Neri A., Cattoretti G., Clynes R., Mendelsohn C., Chaganti R.S.K., Dalla-Favera R.
      Immunity 14:277-289(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, CHROMOSOMAL TRANSLOCATION WITH IGHA1.
      Tissue: Spleen.
    2. "Identification of a family of Fc receptor homologs with preferential B cell expression."
      Davis R.S., Wang Y.-H., Kubagawa H., Cooper M.D.
      Proc. Natl. Acad. Sci. U.S.A. 98:9772-9777(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Lymph node.
    3. "A family of highly diverse human and mouse genes structurally links leukocyte FcR, gp42 and PECAM-1."
      Guselnikov S.V., Ershova S.A., Mechetina L.V., Najakshin A.M., Volkova O.Y., Alabyev B.Y., Taranin A.V.
      Immunogenetics 54:87-95(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [MRNA] OF 88-515 (ISOFORM 2).
      Tissue: Tonsil.
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    7. "IRTAs: a new family of immunoglobulin-like receptors differentially expressed in B cells."
      Miller I., Hatzivassiliou G., Cattoretti G., Mendelsohn C., Dalla-Favera R.
      Blood 99:2662-2669(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION, TISSUE SPECIFICITY.
    8. "Expression of the IRTA1 receptor identifies intraepithelial and subepithelial marginal zone B cells of the mucosa-associated lymphoid tissue (MALT)."
      Falini B., Tiacci E., Pucciarini A., Bigerna B., Kurth J., Hatzivassiliou G., Droetto S., Galletti B.V., Gambacorta M., Orazi A., Pasqualucci L., Miller I., Kueppers R., Dalla-Favera R., Cattoretti G.
      Blood 102:3684-3692(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    9. "Characterization of the recurrent translocation t(1;1)(p36.3;q21.1-2) in non-Hodgkin lymphoma by multicolor banding and fluorescence in situ hybridization analysis."
      Lestou V.S., Ludkovski O., Connors J.M., Gascoyne R.D., Lam W.L., Horsman D.E.
      Genes Chromosomes Cancer 36:375-381(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHROMOSOMAL TRANSLOCATION.
    10. Cited for: FUNCTION, PHOSPHORYLATION, MUTAGENESIS OF TYR-451; TYR-463 AND TYR-493, INTERACTION WITH PTPN6 AND PTPN11.
    11. "T-bet-positive and IRTA1-positive monocytoid B cells differ from marginal zone B cells and epithelial-associated B cells in their antigen profile and topographical distribution."
      Joehrens K., Shimizu Y., Anagnostopoulos I., Schiffmann S., Tiacci E., Falini B., Stein H.
      Haematologica 90:1070-1077(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    12. "Expression of the immunoregulatory molecule FcRH4 defines a distinctive tissue-based population of memory B cells."
      Ehrhardt G.R.A., Hsu J.T., Gartland L., Leu C.-M., Zhang S., Davis R.S., Cooper M.D.
      J. Exp. Med. 202:783-791(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    13. "Expression pattern of the human FcRH/IRTA receptors in normal tissue and in B-chronic lymphocytic leukemia."
      Polson A.G., Zheng B., Elkins K., Chang W., Du C., Dowd P., Yen L., Tan C., Hongo J.-A., Koeppen H., Ebens A.
      Int. Immunol. 18:1363-1373(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiFCRL4_HUMAN
    AccessioniPrimary (citable) accession number: Q96PJ5
    Secondary accession number(s): Q96PJ3, Q96RE0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 114 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3