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Q96PJ5

- FCRL4_HUMAN

UniProt

Q96PJ5 - FCRL4_HUMAN

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Protein

Fc receptor-like protein 4

Gene
FCRL4, FCRH4, IFGP2, IRTA1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May function as an inhibitor of the B-cell receptor signaling. May function in the B-cell-mediated immune response.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei17 – 182Breakpoint for insertion to form FCRL4-IGHA1 fusion protein

GO - Molecular functioni

  1. protein binding Source: IntAct

GO - Biological processi

  1. immune system process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Adaptive immunity, Immunity

Protein family/group databases

MEROPSiI43.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Fc receptor-like protein 4
Short name:
FcR-like protein 4
Short name:
FcRL4
Alternative name(s):
Fc receptor homolog 4
Short name:
FcRH4
IFGP family protein 2
Short name:
hIFGP2
Immune receptor translocation-associated protein 1
CD_antigen: CD307d
Gene namesi
Name:FCRL4
Synonyms:FCRH4, IFGP2, IRTA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:18507. FCRL4.

Subcellular locationi

Cell membrane; Single-pass type I membrane protein 2 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 387368Extracellular Reviewed predictionAdd
BLAST
Transmembranei388 – 40821Helical; Reviewed predictionAdd
BLAST
Topological domaini409 – 515107Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving FCRL4 is found in non-Hodgkin lymphoma (NHG). Translocation t(1;1)(p36.3; q21.1-2).
A chromosomal aberration involving FCRL4 is found in multiple myeloma (MM). Translocation t(1;14)(q21;q32) that forms a FCRL4-IGHA1 fusion protein.

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi451 – 4511Y → F: No effect on function, phosphorylation and interaction with PTPN6 and PTPN11. 1 Publication
Mutagenesisi463 – 4631Y → F: Loss of function, phosphorylation and interaction with PTPN6 and PTPN11. 1 Publication
Mutagenesisi493 – 4931Y → F: Loss of interaction with PTPN6 and PTPN11 and partial loss of function and phosphorylation. 1 Publication

Organism-specific databases

PharmGKBiPA142671768.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed predictionAdd
BLAST
Chaini20 – 515496Fc receptor-like protein 4PRO_0000331642Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi44 ↔ 85 By similarity
Disulfide bondi123 ↔ 167 By similarity
Disulfide bondi212 ↔ 261 By similarity
Disulfide bondi310 ↔ 359 By similarity
Glycosylationi374 – 3741N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

Phosphorylated on cytoplasmic tyrosines upon activation.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ96PJ5.
PRIDEiQ96PJ5.

PTM databases

PhosphoSiteiQ96PJ5.

Expressioni

Tissue specificityi

Specifically expressed by memory and monocytoid B-cells which populate spleen and lymph nodes. Preferentially expressed in memory B-cells associated with mucosal tissue (at protein level).6 Publications

Gene expression databases

BgeeiQ96PJ5.
CleanExiHS_FCRL4.
GenevestigatoriQ96PJ5.

Organism-specific databases

HPAiHPA054030.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TFF1P041553EBI-4314687,EBI-743871
TFF2Q034033EBI-4314687,EBI-4314702

Protein-protein interaction databases

BioGridi123641. 2 interactions.
IntActiQ96PJ5. 2 interactions.
STRINGi9606.ENSP00000271532.

Structurei

3D structure databases

ProteinModelPortaliQ96PJ5.
SMRiQ96PJ5. Positions 22-381.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 9775Ig-like C2-type 1Add
BLAST
Domaini102 – 18382Ig-like C2-type 2Add
BLAST
Domaini193 – 27179Ig-like C2-type 3Add
BLAST
Domaini275 – 374100Ig-like C2-type 4Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi449 – 4546ITIM motif 1
Motifi461 – 4666ITIM motif 2
Motifi491 – 4966ITIM motif 3

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG149358.
HOGENOMiHOG000036945.
InParanoidiQ96PJ5.
OMAiWCGAETV.
OrthoDBiEOG7BP81V.
PhylomeDBiQ96PJ5.
TreeFamiTF351107.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 4 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96PJ5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MLLWASLLAF APVCGQSAAA HKPVISVHPP WTTFFKGERV TLTCNGFQFY    50
ATEKTTWYHR HYWGEKLTLT PGNTLEVRES GLYRCQARGS PRSNPVRLLF 100
SSDSLILQAP YSVFEGDTLV LRCHRRRKEK LTAVKYTWNG NILSISNKSW 150
DLLIPQASSN NNGNYRCIGY GDENDVFRSN FKIIKIQELF PHPELKATDS 200
QPTEGNSVNL SCETQLPPER SDTPLHFNFF RDGEVILSDW STYPELQLPT 250
VWRENSGSYW CGAETVRGNI HKHSPSLQIH VQRIPVSGVL LETQPSGGQA 300
VEGEMLVLVC SVAEGTGDTT FSWHREDMQE SLGRKTQRSL RAELELPAIR 350
QSHAGGYYCT ADNSYGPVQS MVLNVTVRET PGNRDGLVAA GATGGLLSAL 400
LLAVALLFHC WRRRKSGVGF LGDETRLPPA PGPGESSHSI CPAQVELQSL 450
YVDVHPKKGD LVYSEIQTTQ LGEEEEANTS RTLLEDKDVS VVYSEVKTQH 500
PDNSAGKISS KDEES 515
Length:515
Mass (Da):57,224
Last modified:December 1, 2001 - v1
Checksum:iF3B7AD14FB1B449A
GO
Isoform 2 (identifier: Q96PJ5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     454-515: VHPKKGDLVY...GKISSKDEES → GEDSLLGSCS...VEMMLRKRHL

Note: No experimental confirmation available.

Show »
Length:509
Mass (Da):56,636
Checksum:i2810BA15A2BA5405
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti60 – 601R → Q.
Corresponds to variant rs11582663 [ dbSNP | Ensembl ].
VAR_042929
Natural varianti255 – 2551N → S.
Corresponds to variant rs4561035 [ dbSNP | Ensembl ].
VAR_042930
Natural varianti457 – 4571K → R.
Corresponds to variant rs2039401 [ dbSNP | Ensembl ].
VAR_042931
Natural varianti493 – 4931Y → C.
Corresponds to variant rs3811028 [ dbSNP | Ensembl ].
VAR_042932

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei454 – 51562VHPKK…KDEES → GEDSLLGSCSWPQPWKDNAL SALGNAPGLPKVSQIQIFPD IMCPRRVEMMLRKRHL in isoform 2. VSP_033310Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti179 – 1791S → L in AAK93970. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF343659 mRNA. No translation available.
AF397452 mRNA. Translation: AAK93970.1.
AF329490 mRNA. Translation: AAL23900.1.
AF329492 mRNA. Translation: AAL23902.1.
EF064731 Genomic DNA. Translation: ABK41914.1.
CH471121 Genomic DNA. Translation: EAW52883.1.
BC125173 mRNA. Translation: AAI25174.1.
BC125174 mRNA. Translation: AAI25175.1.
CCDSiCCDS1166.1. [Q96PJ5-1]
RefSeqiNP_112572.1. NM_031282.2. [Q96PJ5-1]
UniGeneiHs.120260.

Genome annotation databases

EnsembliENST00000271532; ENSP00000271532; ENSG00000163518. [Q96PJ5-1]
GeneIDi83417.
KEGGihsa:83417.
UCSCiuc001fqw.3. human. [Q96PJ5-1]

Polymorphism databases

DMDMi74761029.

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF343659 mRNA. No translation available.
AF397452 mRNA. Translation: AAK93970.1 .
AF329490 mRNA. Translation: AAL23900.1 .
AF329492 mRNA. Translation: AAL23902.1 .
EF064731 Genomic DNA. Translation: ABK41914.1 .
CH471121 Genomic DNA. Translation: EAW52883.1 .
BC125173 mRNA. Translation: AAI25174.1 .
BC125174 mRNA. Translation: AAI25175.1 .
CCDSi CCDS1166.1. [Q96PJ5-1 ]
RefSeqi NP_112572.1. NM_031282.2. [Q96PJ5-1 ]
UniGenei Hs.120260.

3D structure databases

ProteinModelPortali Q96PJ5.
SMRi Q96PJ5. Positions 22-381.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123641. 2 interactions.
IntActi Q96PJ5. 2 interactions.
STRINGi 9606.ENSP00000271532.

Protein family/group databases

MEROPSi I43.001.

PTM databases

PhosphoSitei Q96PJ5.

Polymorphism databases

DMDMi 74761029.

Proteomic databases

PaxDbi Q96PJ5.
PRIDEi Q96PJ5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000271532 ; ENSP00000271532 ; ENSG00000163518 . [Q96PJ5-1 ]
GeneIDi 83417.
KEGGi hsa:83417.
UCSCi uc001fqw.3. human. [Q96PJ5-1 ]

Organism-specific databases

CTDi 83417.
GeneCardsi GC01M157543.
HGNCi HGNC:18507. FCRL4.
HPAi HPA054030.
MIMi 605876. gene.
neXtProti NX_Q96PJ5.
PharmGKBi PA142671768.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG149358.
HOGENOMi HOG000036945.
InParanoidi Q96PJ5.
OMAi WCGAETV.
OrthoDBi EOG7BP81V.
PhylomeDBi Q96PJ5.
TreeFami TF351107.

Miscellaneous databases

GeneWikii FCRL4.
GenomeRNAii 83417.
NextBioi 72310.
PROi Q96PJ5.
SOURCEi Search...

Gene expression databases

Bgeei Q96PJ5.
CleanExi HS_FCRL4.
Genevestigatori Q96PJ5.

Family and domain databases

Gene3Di 2.60.40.10. 4 hits.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view ]
SMARTi SM00409. IG. 3 hits.
SM00408. IGc2. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "IRTA1 and IRTA2, novel immunoglobulin superfamily receptors expressed in B cells and involved in chromosome 1q21 abnormalities in B cell malignancy."
    Hatzivassiliou G., Miller I., Takizawa J., Palanisamy N., Rao P.H., Iida S., Tagawa S., Taniwaki M., Russo J., Neri A., Cattoretti G., Clynes R., Mendelsohn C., Chaganti R.S.K., Dalla-Favera R.
    Immunity 14:277-289(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, CHROMOSOMAL TRANSLOCATION WITH IGHA1.
    Tissue: Spleen.
  2. "Identification of a family of Fc receptor homologs with preferential B cell expression."
    Davis R.S., Wang Y.-H., Kubagawa H., Cooper M.D.
    Proc. Natl. Acad. Sci. U.S.A. 98:9772-9777(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Lymph node.
  3. "A family of highly diverse human and mouse genes structurally links leukocyte FcR, gp42 and PECAM-1."
    Guselnikov S.V., Ershova S.A., Mechetina L.V., Najakshin A.M., Volkova O.Y., Alabyev B.Y., Taranin A.V.
    Immunogenetics 54:87-95(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [MRNA] OF 88-515 (ISOFORM 2).
    Tissue: Tonsil.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  7. "IRTAs: a new family of immunoglobulin-like receptors differentially expressed in B cells."
    Miller I., Hatzivassiliou G., Cattoretti G., Mendelsohn C., Dalla-Favera R.
    Blood 99:2662-2669(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION, TISSUE SPECIFICITY.
  8. "Expression of the IRTA1 receptor identifies intraepithelial and subepithelial marginal zone B cells of the mucosa-associated lymphoid tissue (MALT)."
    Falini B., Tiacci E., Pucciarini A., Bigerna B., Kurth J., Hatzivassiliou G., Droetto S., Galletti B.V., Gambacorta M., Orazi A., Pasqualucci L., Miller I., Kueppers R., Dalla-Favera R., Cattoretti G.
    Blood 102:3684-3692(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  9. "Characterization of the recurrent translocation t(1;1)(p36.3;q21.1-2) in non-Hodgkin lymphoma by multicolor banding and fluorescence in situ hybridization analysis."
    Lestou V.S., Ludkovski O., Connors J.M., Gascoyne R.D., Lam W.L., Horsman D.E.
    Genes Chromosomes Cancer 36:375-381(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHROMOSOMAL TRANSLOCATION.
  10. Cited for: FUNCTION, PHOSPHORYLATION, MUTAGENESIS OF TYR-451; TYR-463 AND TYR-493, INTERACTION WITH PTPN6 AND PTPN11.
  11. "T-bet-positive and IRTA1-positive monocytoid B cells differ from marginal zone B cells and epithelial-associated B cells in their antigen profile and topographical distribution."
    Joehrens K., Shimizu Y., Anagnostopoulos I., Schiffmann S., Tiacci E., Falini B., Stein H.
    Haematologica 90:1070-1077(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  12. "Expression of the immunoregulatory molecule FcRH4 defines a distinctive tissue-based population of memory B cells."
    Ehrhardt G.R.A., Hsu J.T., Gartland L., Leu C.-M., Zhang S., Davis R.S., Cooper M.D.
    J. Exp. Med. 202:783-791(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  13. "Expression pattern of the human FcRH/IRTA receptors in normal tissue and in B-chronic lymphocytic leukemia."
    Polson A.G., Zheng B., Elkins K., Chang W., Du C., Dowd P., Yen L., Tan C., Hongo J.-A., Koeppen H., Ebens A.
    Int. Immunol. 18:1363-1373(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiFCRL4_HUMAN
AccessioniPrimary (citable) accession number: Q96PJ5
Secondary accession number(s): Q96PJ3, Q96RE0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: December 1, 2001
Last modified: September 3, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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