Q96PG2 (M4A10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Membrane-spanning 4-domains subfamily A member 10

Alternative name(s):
CD20 antigen-like 7

Gene names

Name:	MS4A10
Synonyms:	CD20L7, MS4A9

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	267 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in signal transduction as a component of a multimeric receptor complex.
Subcellular location	Membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the MS4A family.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	Receptor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 267	267	Membrane-spanning 4-domains subfamily A member 10		PRO_0000158646
Regions
	Topological domain	1 – 61	61	Cytoplasmic Potential
	Transmembrane	62 – 82	21	Helical; Potential
	Topological domain	83 – 91	9	Extracellular Potential
	Transmembrane	92 – 112	21	Helical; Potential
	Topological domain	113 – 121	9	Cytoplasmic Potential
	Transmembrane	122 – 142	21	Helical; Potential
	Topological domain	143 – 171	29	Extracellular Potential
	Transmembrane	172 – 192	21	Helical; Potential
	Topological domain	193 – 267	75	Cytoplasmic Potential
Natural variations
	Natural variant	219	1	P → L. Corresponds to variant rs12419635 [ dbSNP | Ensembl ].		VAR_057652
Experimental info
	Sequence conflict	48	1	E → D in BAC85498. Ref.1
	Sequence conflict	263	1	T → A in BAC85498. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q96PG2 [UniParc]. Last modified May 18, 2010. Version 3. Checksum: 39FC0395825B2E78	FASTA	267	29,747
	10 20 30 40 50 60 MKAEATVIPS RCARGLPSWQ VLSPVQPWQT SAPQNTTQPK LLAPHQHEKS QKKSSLLKEL 70 80 90 100 110 120 GAFHITIALL HLVFGGYLAS IVKNLHLVVL KSWYPFWGAA SFLISGILAI TMKTFSKTYL 130 140 150 160 170 180 KMLCLMTNLI SLFCVLSGLF VISKDLFLES PFESPIWRMY PNSTVHIQRL ELALLCFTVL 190 200 210 220 230 240 ELFLPVPTAV TAWRGDCPSA KNDDACLVPN TPLHLKGLPV EPPPSYQSVI QGDAQHKQHQ 250 260 RLREVKQVAP DTWIVTDGAA IWTQTAN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Small intestine.
[2]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"Structural organization of the human MS4A gene cluster on chromosome 11q12." Liang Y., Buckley T.R., Tu L., Langdon S.D., Tedder T.F. Immunogenetics 53:357-368(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-61 AND 202-241.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK122633 mRNA. Translation: BAC85498.1. AP004243 Genomic DNA. No translation available. BC137259 mRNA. Translation: AAI37260.1. BC137263 mRNA. Translation: AAI37264.1. AF354934 Genomic DNA. Translation: AAL07361.1. AF354935 Genomic DNA. Translation: AAL07362.1.
IPI	IPI00163227.
RefSeq	NP_996776.2. NM_206893.3.
UniGene	Hs.591956.
3D structure databases
ProteinModelPortal	Q96PG2.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000311862.
Polymorphism databases
DMDM	296439309.
Proteomic databases
PaxDb	Q96PG2.
PRIDE	Q96PG2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000308287; ENSP00000311862; ENSG00000172689.
GeneID	341116.
KEGG	hsa:341116.
UCSC	uc001npz.1. human.
Organism-specific databases
CTD	341116.
GeneCards	GC11P060552.
H-InvDB	HIX0026191.
HGNC	HGNC:13368. MS4A10.
MIM	608403. gene.
neXtProt	NX_Q96PG2.
PharmGKB	PA31110.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG70916.
HOGENOM	HOG000060092.
HOVERGEN	HBG052385.
InParanoid	Q96PG2.
OMA	STVHIQR.
OrthoDB	EOG466VMN.
PhylomeDB	Q96PG2.
Gene expression databases
Bgee	Q96PG2.
CleanEx	HS_MS4A10.
Genevestigator	Q96PG2.
Family and domain databases
InterPro	IPR007237. CD20-like. [Graphical view]
Pfam	PF04103. CD20. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	341116.
NextBio	98075.
SOURCE	Search...

Entry information

Entry name

M4A10_HUMAN

Accession

Primary (citable) accession number: Q96PG2
Secondary accession number(s): B2RP45, Q96PG3

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 2004
Last sequence update:	May 18, 2010
Last modified:	April 3, 2013
This is version 74 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.