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Protein

Membrane-spanning 4-domains subfamily A member 10

Gene

MS4A10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in signal transduction as a component of a multimeric receptor complex.

Keywords - Molecular functioni

Receptor

Protein family/group databases

TCDBi1.A.37.2.1. the cd20 ca(2+) channel (cd20) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane-spanning 4-domains subfamily A member 10
Alternative name(s):
CD20 antigen-like 7
Gene namesi
Name:MS4A10
Synonyms:CD20L7, MS4A9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:13368. MS4A10.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6161CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei62 – 8221HelicalSequence AnalysisAdd
BLAST
Topological domaini83 – 919ExtracellularSequence Analysis
Transmembranei92 – 11221HelicalSequence AnalysisAdd
BLAST
Topological domaini113 – 1219CytoplasmicSequence Analysis
Transmembranei122 – 14221HelicalSequence AnalysisAdd
BLAST
Topological domaini143 – 17129ExtracellularSequence AnalysisAdd
BLAST
Transmembranei172 – 19221HelicalSequence AnalysisAdd
BLAST
Topological domaini193 – 26775CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31110.

Polymorphism and mutation databases

BioMutaiMS4A10.
DMDMi296439309.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 267267Membrane-spanning 4-domains subfamily A member 10PRO_0000158646Add
BLAST

Proteomic databases

PaxDbiQ96PG2.
PRIDEiQ96PG2.

Expressioni

Gene expression databases

BgeeiQ96PG2.
CleanExiHS_MS4A10.

Organism-specific databases

HPAiHPA014778.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000311862.

Structurei

3D structure databases

ProteinModelPortaliQ96PG2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MS4A family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG70916.
GeneTreeiENSGT00390000010921.
HOGENOMiHOG000060092.
HOVERGENiHBG052385.
InParanoidiQ96PG2.
OMAiKSWYPFW.
OrthoDBiEOG7M98HR.
PhylomeDBiQ96PG2.
TreeFamiTF339722.

Family and domain databases

InterProiIPR007237. CD20-like.
IPR030417. MS4A.
[Graphical view]
PANTHERiPTHR23320. PTHR23320. 1 hit.
PfamiPF04103. CD20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96PG2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAEATVIPS RCARGLPSWQ VLSPVQPWQT SAPQNTTQPK LLAPHQHEKS
60 70 80 90 100
QKKSSLLKEL GAFHITIALL HLVFGGYLAS IVKNLHLVVL KSWYPFWGAA
110 120 130 140 150
SFLISGILAI TMKTFSKTYL KMLCLMTNLI SLFCVLSGLF VISKDLFLES
160 170 180 190 200
PFESPIWRMY PNSTVHIQRL ELALLCFTVL ELFLPVPTAV TAWRGDCPSA
210 220 230 240 250
KNDDACLVPN TPLHLKGLPV EPPPSYQSVI QGDAQHKQHQ RLREVKQVAP
260
DTWIVTDGAA IWTQTAN
Length:267
Mass (Da):29,747
Last modified:May 18, 2010 - v3
Checksum:i39FC0395825B2E78
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti48 – 481E → D in BAC85498 (PubMed:14702039).Curated
Sequence conflicti263 – 2631T → A in BAC85498 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti219 – 2191P → L.
Corresponds to variant rs12419635 [ dbSNP | Ensembl ].
VAR_057652

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122633 mRNA. Translation: BAC85498.1.
AP004243 Genomic DNA. No translation available.
BC137259 mRNA. Translation: AAI37260.1.
BC137263 mRNA. Translation: AAI37264.1.
AF354934 Genomic DNA. Translation: AAL07361.1.
AF354935 Genomic DNA. Translation: AAL07362.1.
CCDSiCCDS7992.1.
RefSeqiNP_996776.2. NM_206893.3.
UniGeneiHs.591956.

Genome annotation databases

EnsembliENST00000308287; ENSP00000311862; ENSG00000172689.
GeneIDi341116.
KEGGihsa:341116.
UCSCiuc001npz.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122633 mRNA. Translation: BAC85498.1.
AP004243 Genomic DNA. No translation available.
BC137259 mRNA. Translation: AAI37260.1.
BC137263 mRNA. Translation: AAI37264.1.
AF354934 Genomic DNA. Translation: AAL07361.1.
AF354935 Genomic DNA. Translation: AAL07362.1.
CCDSiCCDS7992.1.
RefSeqiNP_996776.2. NM_206893.3.
UniGeneiHs.591956.

3D structure databases

ProteinModelPortaliQ96PG2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000311862.

Protein family/group databases

TCDBi1.A.37.2.1. the cd20 ca(2+) channel (cd20) family.

Polymorphism and mutation databases

BioMutaiMS4A10.
DMDMi296439309.

Proteomic databases

PaxDbiQ96PG2.
PRIDEiQ96PG2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308287; ENSP00000311862; ENSG00000172689.
GeneIDi341116.
KEGGihsa:341116.
UCSCiuc001npz.1. human.

Organism-specific databases

CTDi341116.
GeneCardsiGC11P060552.
H-InvDBHIX0026191.
HGNCiHGNC:13368. MS4A10.
HPAiHPA014778.
MIMi608403. gene.
neXtProtiNX_Q96PG2.
PharmGKBiPA31110.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG70916.
GeneTreeiENSGT00390000010921.
HOGENOMiHOG000060092.
HOVERGENiHBG052385.
InParanoidiQ96PG2.
OMAiKSWYPFW.
OrthoDBiEOG7M98HR.
PhylomeDBiQ96PG2.
TreeFamiTF339722.

Miscellaneous databases

GenomeRNAii341116.
NextBioi98075.
PROiQ96PG2.
SOURCEiSearch...

Gene expression databases

BgeeiQ96PG2.
CleanExiHS_MS4A10.

Family and domain databases

InterProiIPR007237. CD20-like.
IPR030417. MS4A.
[Graphical view]
PANTHERiPTHR23320. PTHR23320. 1 hit.
PfamiPF04103. CD20. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Small intestine.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Structural organization of the human MS4A gene cluster on chromosome 11q12."
    Liang Y., Buckley T.R., Tu L., Langdon S.D., Tedder T.F.
    Immunogenetics 53:357-368(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-61 AND 202-241.

Entry informationi

Entry nameiM4A10_HUMAN
AccessioniPrimary (citable) accession number: Q96PG2
Secondary accession number(s): B2RP45, Q96PG3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: May 18, 2010
Last modified: June 24, 2015
This is version 86 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.