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Protein

Membrane-spanning 4-domains subfamily A member 10

Gene

MS4A10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in signal transduction as a component of a multimeric receptor complex.

Keywordsi

Molecular functionReceptor

Protein family/group databases

TCDBi1.A.37.2.1. the cd20 ca(2+) channel (cd20) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane-spanning 4-domains subfamily A member 10
Alternative name(s):
CD20 antigen-like 7
Gene namesi
Name:MS4A10
Synonyms:CD20L7, MS4A9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000172689.1.
HGNCiHGNC:13368. MS4A10.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 61CytoplasmicSequence analysisAdd BLAST61
Transmembranei62 – 82HelicalSequence analysisAdd BLAST21
Topological domaini83 – 91ExtracellularSequence analysis9
Transmembranei92 – 112HelicalSequence analysisAdd BLAST21
Topological domaini113 – 121CytoplasmicSequence analysis9
Transmembranei122 – 142HelicalSequence analysisAdd BLAST21
Topological domaini143 – 171ExtracellularSequence analysisAdd BLAST29
Transmembranei172 – 192HelicalSequence analysisAdd BLAST21
Topological domaini193 – 267CytoplasmicSequence analysisAdd BLAST75

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000172689.
PharmGKBiPA31110.

Polymorphism and mutation databases

BioMutaiMS4A10.
DMDMi296439309.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001586461 – 267Membrane-spanning 4-domains subfamily A member 10Add BLAST267

Proteomic databases

PaxDbiQ96PG2.
PRIDEiQ96PG2.
TopDownProteomicsiQ96PG2.

PTM databases

iPTMnetiQ96PG2.
PhosphoSitePlusiQ96PG2.

Expressioni

Gene expression databases

BgeeiENSG00000172689.
CleanExiHS_MS4A10.

Organism-specific databases

HPAiHPA014778.

Interactioni

Protein-protein interaction databases

BioGridi131117. 7 interactors.
STRINGi9606.ENSP00000311862.

Structurei

3D structure databases

ProteinModelPortaliQ96PG2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MS4A family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWNC. Eukaryota.
ENOG41117F3. LUCA.
GeneTreeiENSGT00390000010921.
HOGENOMiHOG000060092.
HOVERGENiHBG052385.
InParanoidiQ96PG2.
OMAiKSWYPFW.
OrthoDBiEOG091G0IBB.
PhylomeDBiQ96PG2.
TreeFamiTF339722.

Family and domain databases

InterProiView protein in InterPro
IPR007237. CD20-like.
IPR030417. MS4A.
PANTHERiPTHR23320. PTHR23320. 1 hit.
PfamiView protein in Pfam
PF04103. CD20. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96PG2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAEATVIPS RCARGLPSWQ VLSPVQPWQT SAPQNTTQPK LLAPHQHEKS
60 70 80 90 100
QKKSSLLKEL GAFHITIALL HLVFGGYLAS IVKNLHLVVL KSWYPFWGAA
110 120 130 140 150
SFLISGILAI TMKTFSKTYL KMLCLMTNLI SLFCVLSGLF VISKDLFLES
160 170 180 190 200
PFESPIWRMY PNSTVHIQRL ELALLCFTVL ELFLPVPTAV TAWRGDCPSA
210 220 230 240 250
KNDDACLVPN TPLHLKGLPV EPPPSYQSVI QGDAQHKQHQ RLREVKQVAP
260
DTWIVTDGAA IWTQTAN
Length:267
Mass (Da):29,747
Last modified:May 18, 2010 - v3
Checksum:i39FC0395825B2E78
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti48E → D in BAC85498 (PubMed:14702039).Curated1
Sequence conflicti263T → A in BAC85498 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057652219P → L. Corresponds to variant dbSNP:rs12419635Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122633 mRNA. Translation: BAC85498.1.
AP004243 Genomic DNA. No translation available.
BC137259 mRNA. Translation: AAI37260.1.
BC137263 mRNA. Translation: AAI37264.1.
AF354934 Genomic DNA. Translation: AAL07361.1.
AF354935 Genomic DNA. Translation: AAL07362.1.
CCDSiCCDS7992.1.
RefSeqiNP_996776.2. NM_206893.3.
UniGeneiHs.591956.

Genome annotation databases

EnsembliENST00000308287; ENSP00000311862; ENSG00000172689.
GeneIDi341116.
KEGGihsa:341116.
UCSCiuc001npz.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiM4A10_HUMAN
AccessioniPrimary (citable) accession number: Q96PG2
Secondary accession number(s): B2RP45, Q96PG3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: May 18, 2010
Last modified: October 25, 2017
This is version 99 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families