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Q96PG2

- M4A10_HUMAN

UniProt

Q96PG2 - M4A10_HUMAN

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Protein

Membrane-spanning 4-domains subfamily A member 10

Gene
MS4A10, CD20L7, MS4A9
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

May be involved in signal transduction as a component of a multimeric receptor complex.

Keywords - Molecular functioni

Receptor

Protein family/group databases

TCDBi1.A.37.2.1. the cd20 ca(2+) channel (cd20) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane-spanning 4-domains subfamily A member 10
Alternative name(s):
CD20 antigen-like 7
Gene namesi
Name:MS4A10
Synonyms:CD20L7, MS4A9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:13368. MS4A10.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6161Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei62 – 8221Helical; Reviewed predictionAdd
BLAST
Topological domaini83 – 919Extracellular Reviewed prediction
Transmembranei92 – 11221Helical; Reviewed predictionAdd
BLAST
Topological domaini113 – 1219Cytoplasmic Reviewed prediction
Transmembranei122 – 14221Helical; Reviewed predictionAdd
BLAST
Topological domaini143 – 17129Extracellular Reviewed predictionAdd
BLAST
Transmembranei172 – 19221Helical; Reviewed predictionAdd
BLAST
Topological domaini193 – 26775Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31110.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 267267Membrane-spanning 4-domains subfamily A member 10PRO_0000158646Add
BLAST

Proteomic databases

PaxDbiQ96PG2.
PRIDEiQ96PG2.

Expressioni

Gene expression databases

BgeeiQ96PG2.
CleanExiHS_MS4A10.
GenevestigatoriQ96PG2.

Organism-specific databases

HPAiHPA014778.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000311862.

Structurei

3D structure databases

ProteinModelPortaliQ96PG2.

Family & Domainsi

Sequence similaritiesi

Belongs to the MS4A family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG70916.
HOGENOMiHOG000060092.
HOVERGENiHBG052385.
InParanoidiQ96PG2.
OMAiKSWYPFW.
OrthoDBiEOG7M98HR.
PhylomeDBiQ96PG2.
TreeFamiTF339722.

Family and domain databases

InterProiIPR007237. CD20-like.
[Graphical view]
PfamiPF04103. CD20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96PG2-1 [UniParc]FASTAAdd to Basket

« Hide

MKAEATVIPS RCARGLPSWQ VLSPVQPWQT SAPQNTTQPK LLAPHQHEKS    50
QKKSSLLKEL GAFHITIALL HLVFGGYLAS IVKNLHLVVL KSWYPFWGAA 100
SFLISGILAI TMKTFSKTYL KMLCLMTNLI SLFCVLSGLF VISKDLFLES 150
PFESPIWRMY PNSTVHIQRL ELALLCFTVL ELFLPVPTAV TAWRGDCPSA 200
KNDDACLVPN TPLHLKGLPV EPPPSYQSVI QGDAQHKQHQ RLREVKQVAP 250
DTWIVTDGAA IWTQTAN 267
Length:267
Mass (Da):29,747
Last modified:May 18, 2010 - v3
Checksum:i39FC0395825B2E78
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti219 – 2191P → L.
Corresponds to variant rs12419635 [ dbSNP | Ensembl ].
VAR_057652

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti48 – 481E → D in BAC85498. 1 Publication
Sequence conflicti263 – 2631T → A in BAC85498. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK122633 mRNA. Translation: BAC85498.1.
AP004243 Genomic DNA. No translation available.
BC137259 mRNA. Translation: AAI37260.1.
BC137263 mRNA. Translation: AAI37264.1.
AF354934 Genomic DNA. Translation: AAL07361.1.
AF354935 Genomic DNA. Translation: AAL07362.1.
CCDSiCCDS7992.1.
RefSeqiNP_996776.2. NM_206893.3.
UniGeneiHs.591956.

Genome annotation databases

EnsembliENST00000308287; ENSP00000311862; ENSG00000172689.
GeneIDi341116.
KEGGihsa:341116.
UCSCiuc001npz.1. human.

Polymorphism databases

DMDMi296439309.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK122633 mRNA. Translation: BAC85498.1 .
AP004243 Genomic DNA. No translation available.
BC137259 mRNA. Translation: AAI37260.1 .
BC137263 mRNA. Translation: AAI37264.1 .
AF354934 Genomic DNA. Translation: AAL07361.1 .
AF354935 Genomic DNA. Translation: AAL07362.1 .
CCDSi CCDS7992.1.
RefSeqi NP_996776.2. NM_206893.3.
UniGenei Hs.591956.

3D structure databases

ProteinModelPortali Q96PG2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000311862.

Protein family/group databases

TCDBi 1.A.37.2.1. the cd20 ca(2+) channel (cd20) family.

Polymorphism databases

DMDMi 296439309.

Proteomic databases

PaxDbi Q96PG2.
PRIDEi Q96PG2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000308287 ; ENSP00000311862 ; ENSG00000172689 .
GeneIDi 341116.
KEGGi hsa:341116.
UCSCi uc001npz.1. human.

Organism-specific databases

CTDi 341116.
GeneCardsi GC11P060552.
H-InvDB HIX0026191.
HGNCi HGNC:13368. MS4A10.
HPAi HPA014778.
MIMi 608403. gene.
neXtProti NX_Q96PG2.
PharmGKBi PA31110.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG70916.
HOGENOMi HOG000060092.
HOVERGENi HBG052385.
InParanoidi Q96PG2.
OMAi KSWYPFW.
OrthoDBi EOG7M98HR.
PhylomeDBi Q96PG2.
TreeFami TF339722.

Miscellaneous databases

GenomeRNAii 341116.
NextBioi 98075.
PROi Q96PG2.
SOURCEi Search...

Gene expression databases

Bgeei Q96PG2.
CleanExi HS_MS4A10.
Genevestigatori Q96PG2.

Family and domain databases

InterProi IPR007237. CD20-like.
[Graphical view ]
Pfami PF04103. CD20. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Small intestine.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Structural organization of the human MS4A gene cluster on chromosome 11q12."
    Liang Y., Buckley T.R., Tu L., Langdon S.D., Tedder T.F.
    Immunogenetics 53:357-368(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-61 AND 202-241.

Entry informationi

Entry nameiM4A10_HUMAN
AccessioniPrimary (citable) accession number: Q96PG2
Secondary accession number(s): B2RP45, Q96PG3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: May 18, 2010
Last modified: July 9, 2014
This is version 80 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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