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Q96PG2 (M4A10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Membrane-spanning 4-domains subfamily A member 10
Alternative name(s):
CD20 antigen-like 7
Gene names
Name:MS4A10
Synonyms:CD20L7, MS4A9
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length267 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in signal transduction as a component of a multimeric receptor complex.

Subcellular location

Membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the MS4A family.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   Molecular functionReceptor
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 267267Membrane-spanning 4-domains subfamily A member 10
PRO_0000158646

Regions

Topological domain1 – 6161Cytoplasmic Potential
Transmembrane62 – 8221Helical; Potential
Topological domain83 – 919Extracellular Potential
Transmembrane92 – 11221Helical; Potential
Topological domain113 – 1219Cytoplasmic Potential
Transmembrane122 – 14221Helical; Potential
Topological domain143 – 17129Extracellular Potential
Transmembrane172 – 19221Helical; Potential
Topological domain193 – 26775Cytoplasmic Potential

Natural variations

Natural variant2191P → L.
Corresponds to variant rs12419635 [ dbSNP | Ensembl ].
VAR_057652

Experimental info

Sequence conflict481E → D in BAC85498. Ref.1
Sequence conflict2631T → A in BAC85498. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q96PG2 [UniParc].

Last modified May 18, 2010. Version 3.
Checksum: 39FC0395825B2E78

FASTA26729,747
        10         20         30         40         50         60 
MKAEATVIPS RCARGLPSWQ VLSPVQPWQT SAPQNTTQPK LLAPHQHEKS QKKSSLLKEL 

        70         80         90        100        110        120 
GAFHITIALL HLVFGGYLAS IVKNLHLVVL KSWYPFWGAA SFLISGILAI TMKTFSKTYL 

       130        140        150        160        170        180 
KMLCLMTNLI SLFCVLSGLF VISKDLFLES PFESPIWRMY PNSTVHIQRL ELALLCFTVL 

       190        200        210        220        230        240 
ELFLPVPTAV TAWRGDCPSA KNDDACLVPN TPLHLKGLPV EPPPSYQSVI QGDAQHKQHQ 

       250        260 
RLREVKQVAP DTWIVTDGAA IWTQTAN 

« Hide

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Small intestine.
[2]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"Structural organization of the human MS4A gene cluster on chromosome 11q12."
Liang Y., Buckley T.R., Tu L., Langdon S.D., Tedder T.F.
Immunogenetics 53:357-368(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-61 AND 202-241.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK122633 mRNA. Translation: BAC85498.1.
AP004243 Genomic DNA. No translation available.
BC137259 mRNA. Translation: AAI37260.1.
BC137263 mRNA. Translation: AAI37264.1.
AF354934 Genomic DNA. Translation: AAL07361.1.
AF354935 Genomic DNA. Translation: AAL07362.1.
CCDSCCDS7992.1.
RefSeqNP_996776.2. NM_206893.3.
UniGeneHs.591956.

3D structure databases

ProteinModelPortalQ96PG2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000311862.

Protein family/group databases

TCDB1.A.37.2.1. the cd20 ca(2+) channel (cd20) family.

Polymorphism databases

DMDM296439309.

Proteomic databases

PaxDbQ96PG2.
PRIDEQ96PG2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000308287; ENSP00000311862; ENSG00000172689.
GeneID341116.
KEGGhsa:341116.
UCSCuc001npz.1. human.

Organism-specific databases

CTD341116.
GeneCardsGC11P060552.
H-InvDBHIX0026191.
HGNCHGNC:13368. MS4A10.
HPAHPA014778.
MIM608403. gene.
neXtProtNX_Q96PG2.
PharmGKBPA31110.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG70916.
HOGENOMHOG000060092.
HOVERGENHBG052385.
InParanoidQ96PG2.
OMAKSWYPFW.
OrthoDBEOG7M98HR.
PhylomeDBQ96PG2.
TreeFamTF339722.

Gene expression databases

BgeeQ96PG2.
CleanExHS_MS4A10.
GenevestigatorQ96PG2.

Family and domain databases

InterProIPR007237. CD20-like.
[Graphical view]
PfamPF04103. CD20. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi341116.
NextBio98075.
PROQ96PG2.
SOURCESearch...

Entry information

Entry nameM4A10_HUMAN
AccessionPrimary (citable) accession number: Q96PG2
Secondary accession number(s): B2RP45, Q96PG3
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: May 18, 2010
Last modified: July 9, 2014
This is version 80 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM