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Q96PG2

- M4A10_HUMAN

UniProt

Q96PG2 - M4A10_HUMAN

Protein

Membrane-spanning 4-domains subfamily A member 10

Gene

MS4A10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 3 (18 May 2010)
      Previous versions | rss
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    Functioni

    May be involved in signal transduction as a component of a multimeric receptor complex.

    Keywords - Molecular functioni

    Receptor

    Protein family/group databases

    TCDBi1.A.37.2.1. the cd20 ca(2+) channel (cd20) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Membrane-spanning 4-domains subfamily A member 10
    Alternative name(s):
    CD20 antigen-like 7
    Gene namesi
    Name:MS4A10
    Synonyms:CD20L7, MS4A9
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:13368. MS4A10.

    Subcellular locationi

    Membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31110.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 267267Membrane-spanning 4-domains subfamily A member 10PRO_0000158646Add
    BLAST

    Proteomic databases

    PaxDbiQ96PG2.
    PRIDEiQ96PG2.

    Expressioni

    Gene expression databases

    BgeeiQ96PG2.
    CleanExiHS_MS4A10.
    GenevestigatoriQ96PG2.

    Organism-specific databases

    HPAiHPA014778.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000311862.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96PG2.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 6161CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini83 – 919ExtracellularSequence Analysis
    Topological domaini113 – 1219CytoplasmicSequence Analysis
    Topological domaini143 – 17129ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini193 – 26775CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei62 – 8221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei92 – 11221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei122 – 14221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei172 – 19221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the MS4A family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG70916.
    HOGENOMiHOG000060092.
    HOVERGENiHBG052385.
    InParanoidiQ96PG2.
    OMAiKSWYPFW.
    OrthoDBiEOG7M98HR.
    PhylomeDBiQ96PG2.
    TreeFamiTF339722.

    Family and domain databases

    InterProiIPR007237. CD20-like.
    [Graphical view]
    PfamiPF04103. CD20. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96PG2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKAEATVIPS RCARGLPSWQ VLSPVQPWQT SAPQNTTQPK LLAPHQHEKS    50
    QKKSSLLKEL GAFHITIALL HLVFGGYLAS IVKNLHLVVL KSWYPFWGAA 100
    SFLISGILAI TMKTFSKTYL KMLCLMTNLI SLFCVLSGLF VISKDLFLES 150
    PFESPIWRMY PNSTVHIQRL ELALLCFTVL ELFLPVPTAV TAWRGDCPSA 200
    KNDDACLVPN TPLHLKGLPV EPPPSYQSVI QGDAQHKQHQ RLREVKQVAP 250
    DTWIVTDGAA IWTQTAN 267
    Length:267
    Mass (Da):29,747
    Last modified:May 18, 2010 - v3
    Checksum:i39FC0395825B2E78
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti48 – 481E → D in BAC85498. (PubMed:14702039)Curated
    Sequence conflicti263 – 2631T → A in BAC85498. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti219 – 2191P → L.
    Corresponds to variant rs12419635 [ dbSNP | Ensembl ].
    VAR_057652

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK122633 mRNA. Translation: BAC85498.1.
    AP004243 Genomic DNA. No translation available.
    BC137259 mRNA. Translation: AAI37260.1.
    BC137263 mRNA. Translation: AAI37264.1.
    AF354934 Genomic DNA. Translation: AAL07361.1.
    AF354935 Genomic DNA. Translation: AAL07362.1.
    CCDSiCCDS7992.1.
    RefSeqiNP_996776.2. NM_206893.3.
    UniGeneiHs.591956.

    Genome annotation databases

    EnsembliENST00000308287; ENSP00000311862; ENSG00000172689.
    GeneIDi341116.
    KEGGihsa:341116.
    UCSCiuc001npz.1. human.

    Polymorphism databases

    DMDMi296439309.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK122633 mRNA. Translation: BAC85498.1 .
    AP004243 Genomic DNA. No translation available.
    BC137259 mRNA. Translation: AAI37260.1 .
    BC137263 mRNA. Translation: AAI37264.1 .
    AF354934 Genomic DNA. Translation: AAL07361.1 .
    AF354935 Genomic DNA. Translation: AAL07362.1 .
    CCDSi CCDS7992.1.
    RefSeqi NP_996776.2. NM_206893.3.
    UniGenei Hs.591956.

    3D structure databases

    ProteinModelPortali Q96PG2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000311862.

    Protein family/group databases

    TCDBi 1.A.37.2.1. the cd20 ca(2+) channel (cd20) family.

    Polymorphism databases

    DMDMi 296439309.

    Proteomic databases

    PaxDbi Q96PG2.
    PRIDEi Q96PG2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000308287 ; ENSP00000311862 ; ENSG00000172689 .
    GeneIDi 341116.
    KEGGi hsa:341116.
    UCSCi uc001npz.1. human.

    Organism-specific databases

    CTDi 341116.
    GeneCardsi GC11P060552.
    H-InvDB HIX0026191.
    HGNCi HGNC:13368. MS4A10.
    HPAi HPA014778.
    MIMi 608403. gene.
    neXtProti NX_Q96PG2.
    PharmGKBi PA31110.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG70916.
    HOGENOMi HOG000060092.
    HOVERGENi HBG052385.
    InParanoidi Q96PG2.
    OMAi KSWYPFW.
    OrthoDBi EOG7M98HR.
    PhylomeDBi Q96PG2.
    TreeFami TF339722.

    Miscellaneous databases

    GenomeRNAii 341116.
    NextBioi 98075.
    PROi Q96PG2.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q96PG2.
    CleanExi HS_MS4A10.
    Genevestigatori Q96PG2.

    Family and domain databases

    InterProi IPR007237. CD20-like.
    [Graphical view ]
    Pfami PF04103. CD20. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Small intestine.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Structural organization of the human MS4A gene cluster on chromosome 11q12."
      Liang Y., Buckley T.R., Tu L., Langdon S.D., Tedder T.F.
      Immunogenetics 53:357-368(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-61 AND 202-241.

    Entry informationi

    Entry nameiM4A10_HUMAN
    AccessioniPrimary (citable) accession number: Q96PG2
    Secondary accession number(s): B2RP45, Q96PG3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2004
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 81 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3