ID   TGM7_HUMAN              Reviewed;         710 AA.
AC   Q96PF1;
DT   10-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   07-JUL-2009, entry version 63.
DE   RecName: Full=Protein-glutamine gamma-glutamyltransferase Z;
DE            Short=TGase Z;
DE            Short=TGZ;
DE            Short=TG(Z);
DE            EC=2.3.2.13;
DE   AltName: Full=Transglutaminase 7;
GN   Name=TGM7;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=21413858; PubMed=11390390; DOI=10.1074/jbc.M102553200;
RA   Grenard P., Bates M.K., Aeschlimann D.;
RT   "Evolution of transglutaminase genes: identification of a
RT   transglutaminase gene cluster on human chromosome 15q15. Structure of
RT   the gene encoding transglutaminase X and a novel gene family member,
RT   transglutaminase Z.";
RL   J. Biol. Chem. 276:33066-33078(2001).
CC   -!- FUNCTION: Catalyzes the cross-linking of proteins and the
CC       conjugation of polyamines to proteins.
CC   -!- CATALYTIC ACTIVITY: Protein glutamine + alkylamine = protein N(5)-
CC       alkylglutamine + NH(3).
CC   -!- COFACTOR: Binds 1 calcium ion per subunit (By similarity).
CC   -!- TISSUE SPECIFICITY: Widely expressed.
CC   -!- SIMILARITY: Belongs to the transglutaminase superfamily.
CC       Transglutaminase family.
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DR   EMBL; AF363393; AAK97573.1; -; mRNA.
DR   IPI; IPI00044409; -.
DR   RefSeq; NP_443187.1; -.
DR   UniGene; Hs.164661; -.
DR   HSSP; Q08188; 1L9M.
DR   PhosphoSite; Q96PF1; -.
DR   PRIDE; Q96PF1; -.
DR   Ensembl; ENSG00000159495; Homo sapiens.
DR   GeneID; 116179; -.
DR   KEGG; hsa:116179; -.
DR   UCSC; uc001zrf.1; human.
DR   GeneCards; GC15M041355; -.
DR   HGNC; HGNC:30790; TGM7.
DR   MIM; 606776; gene.
DR   PharmGKB; PA134870048; -.
DR   HOGENOM; Q96PF1; -.
DR   HOVERGEN; Q96PF1; -.
DR   OMA; Q96PF1; QLQVLIS.
DR   BRENDA; 2.3.2.13; 247.
DR   DrugBank; DB00130; L-Glutamine.
DR   NextBio; 79821; -.
DR   ArrayExpress; Q96PF1; -.
DR   Bgee; Q96PF1; -.
DR   CleanEx; HS_TGM7; -.
DR   GermOnline; ENSG00000159495; Homo sapiens.
DR   GO; GO:0008415; F:acyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003810; F:protein-glutamine gamma-glutamyltransferase...; IEA:EC.
DR   GO; GO:0018149; P:peptide cross-linking; IEA:InterPro.
DR   InterPro; IPR008957; Fibronectin_typ-III-like_fold.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR002931; Transglutaminase-like.
DR   InterPro; IPR008958; Transglutaminase_C.
DR   InterPro; IPR013808; Transglutaminase_CS.
DR   InterPro; IPR001102; Transglutaminase_N.
DR   Gene3D; G3DSA:2.60.40.30; FN_III-like; 1.
DR   Gene3D; G3DSA:2.60.40.10; Ig-like_fold; 2.
DR   Pfam; PF00927; Transglut_C; 2.
DR   Pfam; PF01841; Transglut_core; 1.
DR   Pfam; PF00868; Transglut_N; 1.
DR   SMART; SM00460; TGc; 1.
DR   PROSITE; PS00547; TRANSGLUTAMINASES; 1.
PE   2: Evidence at transcript level;
KW   Acyltransferase; Calcium; Complete proteome; Metal-binding;
KW   Transferase.
FT   CHAIN         1    710       Protein-glutamine gamma-
FT                                glutamyltransferase Z.
FT                                /FTId=PRO_0000213716.
FT   ACT_SITE    279    279       By similarity.
FT   ACT_SITE    338    338       By similarity.
FT   ACT_SITE    361    361       By similarity.
FT   METAL       401    401       Calcium (By similarity).
FT   METAL       403    403       Calcium (By similarity).
FT   METAL       450    450       Calcium (By similarity).
FT   METAL       455    455       Calcium (By similarity).
SQ   SEQUENCE   710 AA;  79941 MW;  046C5ED002563909 CRC64;
     MDQVATLRLE SVDLQSSRNN KEHHTQEMGV KRLTVRRGQP FYLRLSFSRP FQSQNDHITF
     VAETGPKPSE LLGTRATFFL TRVQPGNVWS ASDFTIDSNS LQVSLFTPAN AVIGHYTLKI
     EISQGQGHSV TYPLGTFILL FNPWSPEDDV YLPSEILLQE YIMRDYGFVY KGHERFITSW
     PWNYGQFEED IIDICFEILN KSLYHLKNPA KDCSQRNDVV YVCRVVSAMI NSNDDNGVLQ
     GNWGEDYSKG VSPLEWKGSV AILQQWSARG GQPVKYGQCW VFASVMCTVM RCLGVPTRVV
     SNFRSAHNVD RNLTIDTYYD RNAEMLSTQK RDKIWNFHVW NECWMIRKDL PPGYNGWQVL
     DPTPQQTSSG LFCCGPASVK AIREGDVHLA YDTPFVYAEV NADEVIWLLG DGQAQEILAH
     NTSSIGKEIS TKMVGSDQRQ SITSSYKYPE GSPEERAVFM KASRKMLGPQ RASLPFLDLL
     ESGGLRDQPA QLQLHLARIP EWGQDLQLLL RIQRVPDSTH PRGPIGLVVR FCAQALLHGG
     GTQKPFWRHT VRMNLDFGKE TQWPLLLPYS NYRNKLTDEK LIRVSGIAEV EETGRSMLVL
     KDICLEPPHL SIEVSERAEV GKALRVHVTL TNTLMVALSS CTMVLEGSGL INGQIAKDLG
     TLVAGHTLQI QLDLYPTKAG PRQLQVLISS NEVKEIKGYK DIFVTVAGAP
//