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Protein

Protein-glutamine gamma-glutamyltransferase Z

Gene

TGM7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.

Catalytic activityi

Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH3.PROSITE-ProRule annotation

Cofactori

Ca2+By similarityNote: Binds 1 Ca2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei279 – 2791PROSITE-ProRule annotation
Active sitei338 – 3381PROSITE-ProRule annotation
Active sitei361 – 3611PROSITE-ProRule annotation
Metal bindingi401 – 4011CalciumBy similarity
Metal bindingi403 – 4031CalciumBy similarity
Metal bindingi450 – 4501CalciumBy similarity
Metal bindingi455 – 4551CalciumBy similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein-glutamine gamma-glutamyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. peptide cross-linking Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-glutamine gamma-glutamyltransferase Z
Alternative name(s):
Transglutaminase Z (EC:2.3.2.13)
Short name:
TG(Z)
Short name:
TGZ
Short name:
TGase Z
Transglutaminase-7
Short name:
TGase-7
Gene namesi
Name:TGM7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:30790. TGM7.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134870048.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 710710Protein-glutamine gamma-glutamyltransferase ZPRO_0000213716Add
BLAST

Proteomic databases

PaxDbiQ96PF1.
PRIDEiQ96PF1.

PTM databases

PhosphoSiteiQ96PF1.

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

BgeeiQ96PF1.
CleanExiHS_TGM7.
GenevestigatoriQ96PF1.

Structurei

3D structure databases

ProteinModelPortaliQ96PF1.
SMRiQ96PF1. Positions 7-702.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG299687.
GeneTreeiENSGT00760000119108.
HOGENOMiHOG000231695.
HOVERGENiHBG004342.
InParanoidiQ96PF1.
KOiK05623.
OMAiRFCAQAL.
OrthoDBiEOG7WT40M.
PhylomeDBiQ96PF1.
TreeFamiTF324278.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProiIPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view]
PANTHERiPTHR11590. PTHR11590. 1 hit.
PfamiPF00927. Transglut_C. 1 hit.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000459. TGM_EBP42. 1 hit.
SMARTiSM00460. TGc. 1 hit.
[Graphical view]
SUPFAMiSSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96PF1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDQVATLRLE SVDLQSSRNN KEHHTQEMGV KRLTVRRGQP FYLRLSFSRP
60 70 80 90 100
FQSQNDHITF VAETGPKPSE LLGTRATFFL TRVQPGNVWS ASDFTIDSNS
110 120 130 140 150
LQVSLFTPAN AVIGHYTLKI EISQGQGHSV TYPLGTFILL FNPWSPEDDV
160 170 180 190 200
YLPSEILLQE YIMRDYGFVY KGHERFITSW PWNYGQFEED IIDICFEILN
210 220 230 240 250
KSLYHLKNPA KDCSQRNDVV YVCRVVSAMI NSNDDNGVLQ GNWGEDYSKG
260 270 280 290 300
VSPLEWKGSV AILQQWSARG GQPVKYGQCW VFASVMCTVM RCLGVPTRVV
310 320 330 340 350
SNFRSAHNVD RNLTIDTYYD RNAEMLSTQK RDKIWNFHVW NECWMIRKDL
360 370 380 390 400
PPGYNGWQVL DPTPQQTSSG LFCCGPASVK AIREGDVHLA YDTPFVYAEV
410 420 430 440 450
NADEVIWLLG DGQAQEILAH NTSSIGKEIS TKMVGSDQRQ SITSSYKYPE
460 470 480 490 500
GSPEERAVFM KASRKMLGPQ RASLPFLDLL ESGGLRDQPA QLQLHLARIP
510 520 530 540 550
EWGQDLQLLL RIQRVPDSTH PRGPIGLVVR FCAQALLHGG GTQKPFWRHT
560 570 580 590 600
VRMNLDFGKE TQWPLLLPYS NYRNKLTDEK LIRVSGIAEV EETGRSMLVL
610 620 630 640 650
KDICLEPPHL SIEVSERAEV GKALRVHVTL TNTLMVALSS CTMVLEGSGL
660 670 680 690 700
INGQIAKDLG TLVAGHTLQI QLDLYPTKAG PRQLQVLISS NEVKEIKGYK
710
DIFVTVAGAP
Length:710
Mass (Da):79,941
Last modified:December 1, 2001 - v1
Checksum:i046C5ED002563909
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF363393 mRNA. Translation: AAK97573.1.
CCDSiCCDS32213.1.
RefSeqiNP_443187.1. NM_052955.2.
UniGeneiHs.164661.

Genome annotation databases

EnsembliENST00000452443; ENSP00000389466; ENSG00000159495.
GeneIDi116179.
KEGGihsa:116179.
UCSCiuc001zrf.1. human.

Polymorphism databases

DMDMi20532271.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF363393 mRNA. Translation: AAK97573.1.
CCDSiCCDS32213.1.
RefSeqiNP_443187.1. NM_052955.2.
UniGeneiHs.164661.

3D structure databases

ProteinModelPortaliQ96PF1.
SMRiQ96PF1. Positions 7-702.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

DrugBankiDB00130. L-Glutamine.

PTM databases

PhosphoSiteiQ96PF1.

Polymorphism databases

DMDMi20532271.

Proteomic databases

PaxDbiQ96PF1.
PRIDEiQ96PF1.

Protocols and materials databases

DNASUi116179.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000452443; ENSP00000389466; ENSG00000159495.
GeneIDi116179.
KEGGihsa:116179.
UCSCiuc001zrf.1. human.

Organism-specific databases

CTDi116179.
GeneCardsiGC15M043568.
HGNCiHGNC:30790. TGM7.
MIMi606776. gene.
neXtProtiNX_Q96PF1.
PharmGKBiPA134870048.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG299687.
GeneTreeiENSGT00760000119108.
HOGENOMiHOG000231695.
HOVERGENiHBG004342.
InParanoidiQ96PF1.
KOiK05623.
OMAiRFCAQAL.
OrthoDBiEOG7WT40M.
PhylomeDBiQ96PF1.
TreeFamiTF324278.

Miscellaneous databases

GenomeRNAii116179.
NextBioi79821.
PROiQ96PF1.
SOURCEiSearch...

Gene expression databases

BgeeiQ96PF1.
CleanExiHS_TGM7.
GenevestigatoriQ96PF1.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProiIPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view]
PANTHERiPTHR11590. PTHR11590. 1 hit.
PfamiPF00927. Transglut_C. 1 hit.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000459. TGM_EBP42. 1 hit.
SMARTiSM00460. TGc. 1 hit.
[Graphical view]
SUPFAMiSSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Evolution of transglutaminase genes: identification of a transglutaminase gene cluster on human chromosome 15q15. Structure of the gene encoding transglutaminase X and a novel gene family member, transglutaminase Z."
    Grenard P., Bates M.K., Aeschlimann D.
    J. Biol. Chem. 276:33066-33078(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiTGM7_HUMAN
AccessioniPrimary (citable) accession number: Q96PF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: December 1, 2001
Last modified: January 7, 2015
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.