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Q96PF1 (TGM7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein-glutamine gamma-glutamyltransferase Z
Alternative name(s):
Transglutaminase Z
Short name=TG(Z)
Short name=TGZ
Short name=TGase Z
EC=2.3.2.13
Transglutaminase-7
Short name=TGase-7
Gene names
Name:TGM7
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length710 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.

Catalytic activity

Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH3.

Cofactor

Binds 1 calcium ion per subunit By similarity.

Tissue specificity

Widely expressed.

Sequence similarities

Belongs to the transglutaminase superfamily. Transglutaminase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 710710Protein-glutamine gamma-glutamyltransferase Z
PRO_0000213716

Sites

Active site2791 By similarity
Active site3381 By similarity
Active site3611 By similarity
Metal binding4011Calcium By similarity
Metal binding4031Calcium By similarity
Metal binding4501Calcium By similarity
Metal binding4551Calcium By similarity

Sequences

Sequence LengthMass (Da)Tools
Q96PF1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 046C5ED002563909

FASTA71079,941
        10         20         30         40         50         60 
MDQVATLRLE SVDLQSSRNN KEHHTQEMGV KRLTVRRGQP FYLRLSFSRP FQSQNDHITF 

        70         80         90        100        110        120 
VAETGPKPSE LLGTRATFFL TRVQPGNVWS ASDFTIDSNS LQVSLFTPAN AVIGHYTLKI 

       130        140        150        160        170        180 
EISQGQGHSV TYPLGTFILL FNPWSPEDDV YLPSEILLQE YIMRDYGFVY KGHERFITSW 

       190        200        210        220        230        240 
PWNYGQFEED IIDICFEILN KSLYHLKNPA KDCSQRNDVV YVCRVVSAMI NSNDDNGVLQ 

       250        260        270        280        290        300 
GNWGEDYSKG VSPLEWKGSV AILQQWSARG GQPVKYGQCW VFASVMCTVM RCLGVPTRVV 

       310        320        330        340        350        360 
SNFRSAHNVD RNLTIDTYYD RNAEMLSTQK RDKIWNFHVW NECWMIRKDL PPGYNGWQVL 

       370        380        390        400        410        420 
DPTPQQTSSG LFCCGPASVK AIREGDVHLA YDTPFVYAEV NADEVIWLLG DGQAQEILAH 

       430        440        450        460        470        480 
NTSSIGKEIS TKMVGSDQRQ SITSSYKYPE GSPEERAVFM KASRKMLGPQ RASLPFLDLL 

       490        500        510        520        530        540 
ESGGLRDQPA QLQLHLARIP EWGQDLQLLL RIQRVPDSTH PRGPIGLVVR FCAQALLHGG 

       550        560        570        580        590        600 
GTQKPFWRHT VRMNLDFGKE TQWPLLLPYS NYRNKLTDEK LIRVSGIAEV EETGRSMLVL 

       610        620        630        640        650        660 
KDICLEPPHL SIEVSERAEV GKALRVHVTL TNTLMVALSS CTMVLEGSGL INGQIAKDLG 

       670        680        690        700        710 
TLVAGHTLQI QLDLYPTKAG PRQLQVLISS NEVKEIKGYK DIFVTVAGAP 

« Hide

References

[1]"Evolution of transglutaminase genes: identification of a transglutaminase gene cluster on human chromosome 15q15. Structure of the gene encoding transglutaminase X and a novel gene family member, transglutaminase Z."
Grenard P., Bates M.K., Aeschlimann D.
J. Biol. Chem. 276:33066-33078(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF363393 mRNA. Translation: AAK97573.1.
RefSeqNP_443187.1. NM_052955.2.
UniGeneHs.164661.

3D structure databases

ProteinModelPortalQ96PF1.
SMRQ96PF1. Positions 7-702.
ModBaseSearch...
MobiDBSearch...

Chemistry

DrugBankDB00130. L-Glutamine.

PTM databases

PhosphoSiteQ96PF1.

Polymorphism databases

DMDM20532271.

Proteomic databases

PaxDbQ96PF1.
PRIDEQ96PF1.

Protocols and materials databases

DNASU116179.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000452443; ENSP00000389466; ENSG00000159495.
GeneID116179.
KEGGhsa:116179.
UCSCuc001zrf.1. human.

Organism-specific databases

CTD116179.
GeneCardsGC15M043568.
HGNCHGNC:30790. TGM7.
MIM606776. gene.
neXtProtNX_Q96PF1.
PharmGKBPA134870048.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG299687.
HOGENOMHOG000231695.
HOVERGENHBG004342.
InParanoidQ96PF1.
KOK05623.
OMARFCAQAL.
OrthoDBEOG7WT40M.
PhylomeDBQ96PF1.
TreeFamTF324278.

Gene expression databases

BgeeQ96PF1.
CleanExHS_TGM7.
GenevestigatorQ96PF1.

Family and domain databases

Gene3D2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProIPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view]
PANTHERPTHR11590. PTHR11590. 1 hit.
PfamPF00927. Transglut_C. 1 hit.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view]
PIRSFPIRSF000459. TGM_EBP42. 1 hit.
SMARTSM00460. TGc. 1 hit.
[Graphical view]
SUPFAMSSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEPS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi116179.
NextBio79821.
PROQ96PF1.
SOURCESearch...

Entry information

Entry nameTGM7_HUMAN
AccessionPrimary (citable) accession number: Q96PF1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: December 1, 2001
Last modified: February 19, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 15

Human chromosome 15: entries, gene names and cross-references to MIM