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Protein

Protein-glutamine gamma-glutamyltransferase Z

Gene

TGM7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.

Catalytic activityi

A protein-L-glutamine + a protein-L-lysine = a protein with an N6-(gamma-glutamyl)-L-lysine cross-link + NH3.PROSITE-ProRule annotation

Cofactori

Ca2+By similarityNote: Binds 1 Ca2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei279PROSITE-ProRule annotation1
Active sitei338PROSITE-ProRule annotation1
Active sitei361PROSITE-ProRule annotation1
Metal bindingi401CalciumBy similarity1
Metal bindingi403CalciumBy similarity1
Metal bindingi450CalciumBy similarity1
Metal bindingi455CalciumBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-glutamine gamma-glutamyltransferase Z
Alternative name(s):
Transglutaminase Z (EC:2.3.2.13)
Short name:
TG(Z)
Short name:
TGZ
Short name:
TGase Z
Transglutaminase-7
Short name:
TGase-7
Gene namesi
Name:TGM7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000159495.7.
HGNCiHGNC:30790. TGM7.

Pathology & Biotechi

Organism-specific databases

DisGeNETi116179.
OpenTargetsiENSG00000159495.
PharmGKBiPA134870048.

Chemistry databases

DrugBankiDB00130. L-Glutamine.

Polymorphism and mutation databases

BioMutaiTGM7.
DMDMi20532271.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002137161 – 710Protein-glutamine gamma-glutamyltransferase ZAdd BLAST710

Proteomic databases

PaxDbiQ96PF1.
PeptideAtlasiQ96PF1.
PRIDEiQ96PF1.

PTM databases

iPTMnetiQ96PF1.
PhosphoSitePlusiQ96PF1.

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

BgeeiENSG00000159495.
CleanExiHS_TGM7.
GenevisibleiQ96PF1. HS.

Interactioni

Protein-protein interaction databases

IntActiQ96PF1. 18 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ96PF1.
SMRiQ96PF1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IFMV. Eukaryota.
ENOG410XQEZ. LUCA.
GeneTreeiENSGT00760000119108.
HOGENOMiHOG000231695.
HOVERGENiHBG004342.
InParanoidiQ96PF1.
KOiK05623.
OMAiMKASRKM.
OrthoDBiEOG091G030K.
PhylomeDBiQ96PF1.
TreeFamiTF324278.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProiView protein in InterPro
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR036985. Transglutaminase-like_sf.
IPR023608. Transglutaminase_animal.
IPR013808. Transglutaminase_AS.
IPR008958. Transglutaminase_C.
IPR036238. Transglutaminase_C_sf.
IPR001102. Transglutaminase_N.
PfamiView protein in Pfam
PF00927. Transglut_C. 1 hit.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
PIRSFiPIRSF000459. TGM_EBP42. 1 hit.
SMARTiView protein in SMART
SM00460. TGc. 1 hit.
SUPFAMiSSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEiView protein in PROSITE
PS00547. TRANSGLUTAMINASES. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96PF1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQVATLRLE SVDLQSSRNN KEHHTQEMGV KRLTVRRGQP FYLRLSFSRP
60 70 80 90 100
FQSQNDHITF VAETGPKPSE LLGTRATFFL TRVQPGNVWS ASDFTIDSNS
110 120 130 140 150
LQVSLFTPAN AVIGHYTLKI EISQGQGHSV TYPLGTFILL FNPWSPEDDV
160 170 180 190 200
YLPSEILLQE YIMRDYGFVY KGHERFITSW PWNYGQFEED IIDICFEILN
210 220 230 240 250
KSLYHLKNPA KDCSQRNDVV YVCRVVSAMI NSNDDNGVLQ GNWGEDYSKG
260 270 280 290 300
VSPLEWKGSV AILQQWSARG GQPVKYGQCW VFASVMCTVM RCLGVPTRVV
310 320 330 340 350
SNFRSAHNVD RNLTIDTYYD RNAEMLSTQK RDKIWNFHVW NECWMIRKDL
360 370 380 390 400
PPGYNGWQVL DPTPQQTSSG LFCCGPASVK AIREGDVHLA YDTPFVYAEV
410 420 430 440 450
NADEVIWLLG DGQAQEILAH NTSSIGKEIS TKMVGSDQRQ SITSSYKYPE
460 470 480 490 500
GSPEERAVFM KASRKMLGPQ RASLPFLDLL ESGGLRDQPA QLQLHLARIP
510 520 530 540 550
EWGQDLQLLL RIQRVPDSTH PRGPIGLVVR FCAQALLHGG GTQKPFWRHT
560 570 580 590 600
VRMNLDFGKE TQWPLLLPYS NYRNKLTDEK LIRVSGIAEV EETGRSMLVL
610 620 630 640 650
KDICLEPPHL SIEVSERAEV GKALRVHVTL TNTLMVALSS CTMVLEGSGL
660 670 680 690 700
INGQIAKDLG TLVAGHTLQI QLDLYPTKAG PRQLQVLISS NEVKEIKGYK
710
DIFVTVAGAP
Length:710
Mass (Da):79,941
Last modified:December 1, 2001 - v1
Checksum:i046C5ED002563909
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF363393 mRNA. Translation: AAK97573.1.
CCDSiCCDS32213.1.
RefSeqiNP_443187.1. NM_052955.2.
UniGeneiHs.164661.

Genome annotation databases

EnsembliENST00000452443; ENSP00000389466; ENSG00000159495.
GeneIDi116179.
KEGGihsa:116179.
UCSCiuc001zrf.2. human.

Similar proteinsi

Entry informationi

Entry nameiTGM7_HUMAN
AccessioniPrimary (citable) accession number: Q96PF1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: December 1, 2001
Last modified: November 22, 2017
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families