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Q96PF1

- TGM7_HUMAN

UniProt

Q96PF1 - TGM7_HUMAN

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Protein

Protein-glutamine gamma-glutamyltransferase Z

Gene

TGM7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.

Catalytic activityi

Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH3.PROSITE-ProRule annotation

Cofactori

Binds 1 calcium ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei279 – 2791PROSITE-ProRule annotation
Active sitei338 – 3381PROSITE-ProRule annotation
Active sitei361 – 3611PROSITE-ProRule annotation
Metal bindingi401 – 4011CalciumBy similarity
Metal bindingi403 – 4031CalciumBy similarity
Metal bindingi450 – 4501CalciumBy similarity
Metal bindingi455 – 4551CalciumBy similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein-glutamine gamma-glutamyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. peptide cross-linking Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-glutamine gamma-glutamyltransferase Z
Alternative name(s):
Transglutaminase Z (EC:2.3.2.13)
Short name:
TG(Z)
Short name:
TGZ
Short name:
TGase Z
Transglutaminase-7
Short name:
TGase-7
Gene namesi
Name:TGM7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:30790. TGM7.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134870048.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 710710Protein-glutamine gamma-glutamyltransferase ZPRO_0000213716Add
BLAST

Proteomic databases

PaxDbiQ96PF1.
PRIDEiQ96PF1.

PTM databases

PhosphoSiteiQ96PF1.

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

BgeeiQ96PF1.
CleanExiHS_TGM7.
GenevestigatoriQ96PF1.

Structurei

3D structure databases

ProteinModelPortaliQ96PF1.
SMRiQ96PF1. Positions 7-702.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG299687.
GeneTreeiENSGT00760000119108.
HOGENOMiHOG000231695.
HOVERGENiHBG004342.
InParanoidiQ96PF1.
KOiK05623.
OMAiRFCAQAL.
OrthoDBiEOG7WT40M.
PhylomeDBiQ96PF1.
TreeFamiTF324278.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProiIPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view]
PANTHERiPTHR11590. PTHR11590. 1 hit.
PfamiPF00927. Transglut_C. 1 hit.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000459. TGM_EBP42. 1 hit.
SMARTiSM00460. TGc. 1 hit.
[Graphical view]
SUPFAMiSSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96PF1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDQVATLRLE SVDLQSSRNN KEHHTQEMGV KRLTVRRGQP FYLRLSFSRP
60 70 80 90 100
FQSQNDHITF VAETGPKPSE LLGTRATFFL TRVQPGNVWS ASDFTIDSNS
110 120 130 140 150
LQVSLFTPAN AVIGHYTLKI EISQGQGHSV TYPLGTFILL FNPWSPEDDV
160 170 180 190 200
YLPSEILLQE YIMRDYGFVY KGHERFITSW PWNYGQFEED IIDICFEILN
210 220 230 240 250
KSLYHLKNPA KDCSQRNDVV YVCRVVSAMI NSNDDNGVLQ GNWGEDYSKG
260 270 280 290 300
VSPLEWKGSV AILQQWSARG GQPVKYGQCW VFASVMCTVM RCLGVPTRVV
310 320 330 340 350
SNFRSAHNVD RNLTIDTYYD RNAEMLSTQK RDKIWNFHVW NECWMIRKDL
360 370 380 390 400
PPGYNGWQVL DPTPQQTSSG LFCCGPASVK AIREGDVHLA YDTPFVYAEV
410 420 430 440 450
NADEVIWLLG DGQAQEILAH NTSSIGKEIS TKMVGSDQRQ SITSSYKYPE
460 470 480 490 500
GSPEERAVFM KASRKMLGPQ RASLPFLDLL ESGGLRDQPA QLQLHLARIP
510 520 530 540 550
EWGQDLQLLL RIQRVPDSTH PRGPIGLVVR FCAQALLHGG GTQKPFWRHT
560 570 580 590 600
VRMNLDFGKE TQWPLLLPYS NYRNKLTDEK LIRVSGIAEV EETGRSMLVL
610 620 630 640 650
KDICLEPPHL SIEVSERAEV GKALRVHVTL TNTLMVALSS CTMVLEGSGL
660 670 680 690 700
INGQIAKDLG TLVAGHTLQI QLDLYPTKAG PRQLQVLISS NEVKEIKGYK
710
DIFVTVAGAP
Length:710
Mass (Da):79,941
Last modified:December 1, 2001 - v1
Checksum:i046C5ED002563909
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF363393 mRNA. Translation: AAK97573.1.
CCDSiCCDS32213.1.
RefSeqiNP_443187.1. NM_052955.2.
UniGeneiHs.164661.

Genome annotation databases

EnsembliENST00000452443; ENSP00000389466; ENSG00000159495.
GeneIDi116179.
KEGGihsa:116179.
UCSCiuc001zrf.1. human.

Polymorphism databases

DMDMi20532271.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF363393 mRNA. Translation: AAK97573.1 .
CCDSi CCDS32213.1.
RefSeqi NP_443187.1. NM_052955.2.
UniGenei Hs.164661.

3D structure databases

ProteinModelPortali Q96PF1.
SMRi Q96PF1. Positions 7-702.
ModBasei Search...
MobiDBi Search...

Chemistry

DrugBanki DB00130. L-Glutamine.

PTM databases

PhosphoSitei Q96PF1.

Polymorphism databases

DMDMi 20532271.

Proteomic databases

PaxDbi Q96PF1.
PRIDEi Q96PF1.

Protocols and materials databases

DNASUi 116179.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000452443 ; ENSP00000389466 ; ENSG00000159495 .
GeneIDi 116179.
KEGGi hsa:116179.
UCSCi uc001zrf.1. human.

Organism-specific databases

CTDi 116179.
GeneCardsi GC15M043568.
HGNCi HGNC:30790. TGM7.
MIMi 606776. gene.
neXtProti NX_Q96PF1.
PharmGKBi PA134870048.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG299687.
GeneTreei ENSGT00760000119108.
HOGENOMi HOG000231695.
HOVERGENi HBG004342.
InParanoidi Q96PF1.
KOi K05623.
OMAi RFCAQAL.
OrthoDBi EOG7WT40M.
PhylomeDBi Q96PF1.
TreeFami TF324278.

Miscellaneous databases

GenomeRNAii 116179.
NextBioi 79821.
PROi Q96PF1.
SOURCEi Search...

Gene expression databases

Bgeei Q96PF1.
CleanExi HS_TGM7.
Genevestigatori Q96PF1.

Family and domain databases

Gene3Di 2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProi IPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view ]
PANTHERi PTHR11590. PTHR11590. 1 hit.
Pfami PF00927. Transglut_C. 1 hit.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000459. TGM_EBP42. 1 hit.
SMARTi SM00460. TGc. 1 hit.
[Graphical view ]
SUPFAMi SSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEi PS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of transglutaminase genes: identification of a transglutaminase gene cluster on human chromosome 15q15. Structure of the gene encoding transglutaminase X and a novel gene family member, transglutaminase Z."
    Grenard P., Bates M.K., Aeschlimann D.
    J. Biol. Chem. 276:33066-33078(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiTGM7_HUMAN
AccessioniPrimary (citable) accession number: Q96PF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3