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Q96PF1

- TGM7_HUMAN

UniProt

Q96PF1 - TGM7_HUMAN

Protein

Protein-glutamine gamma-glutamyltransferase Z

Gene

TGM7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.

    Catalytic activityi

    Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH3.PROSITE-ProRule annotation

    Cofactori

    Binds 1 calcium ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei279 – 2791PROSITE-ProRule annotation
    Active sitei338 – 3381PROSITE-ProRule annotation
    Active sitei361 – 3611PROSITE-ProRule annotation
    Metal bindingi401 – 4011CalciumBy similarity
    Metal bindingi403 – 4031CalciumBy similarity
    Metal bindingi450 – 4501CalciumBy similarity
    Metal bindingi455 – 4551CalciumBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein-glutamine gamma-glutamyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. peptide cross-linking Source: InterPro

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein-glutamine gamma-glutamyltransferase Z
    Alternative name(s):
    Transglutaminase Z (EC:2.3.2.13)
    Short name:
    TG(Z)
    Short name:
    TGZ
    Short name:
    TGase Z
    Transglutaminase-7
    Short name:
    TGase-7
    Gene namesi
    Name:TGM7
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:30790. TGM7.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134870048.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 710710Protein-glutamine gamma-glutamyltransferase ZPRO_0000213716Add
    BLAST

    Proteomic databases

    PaxDbiQ96PF1.
    PRIDEiQ96PF1.

    PTM databases

    PhosphoSiteiQ96PF1.

    Expressioni

    Tissue specificityi

    Widely expressed.

    Gene expression databases

    BgeeiQ96PF1.
    CleanExiHS_TGM7.
    GenevestigatoriQ96PF1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96PF1.
    SMRiQ96PF1. Positions 7-702.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG299687.
    HOGENOMiHOG000231695.
    HOVERGENiHBG004342.
    InParanoidiQ96PF1.
    KOiK05623.
    OMAiRFCAQAL.
    OrthoDBiEOG7WT40M.
    PhylomeDBiQ96PF1.
    TreeFamiTF324278.

    Family and domain databases

    Gene3Di2.60.40.10. 3 hits.
    3.90.260.10. 1 hit.
    InterProiIPR023608. Gln_gamma-glutamylTfrase_euk.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR002931. Transglutaminase-like.
    IPR008958. Transglutaminase_C.
    IPR013808. Transglutaminase_CS.
    IPR001102. Transglutaminase_N.
    [Graphical view]
    PANTHERiPTHR11590. PTHR11590. 1 hit.
    PfamiPF00927. Transglut_C. 1 hit.
    PF01841. Transglut_core. 1 hit.
    PF00868. Transglut_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000459. TGM_EBP42. 1 hit.
    SMARTiSM00460. TGc. 1 hit.
    [Graphical view]
    SUPFAMiSSF49309. SSF49309. 2 hits.
    SSF81296. SSF81296. 1 hit.
    PROSITEiPS00547. TRANSGLUTAMINASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96PF1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDQVATLRLE SVDLQSSRNN KEHHTQEMGV KRLTVRRGQP FYLRLSFSRP    50
    FQSQNDHITF VAETGPKPSE LLGTRATFFL TRVQPGNVWS ASDFTIDSNS 100
    LQVSLFTPAN AVIGHYTLKI EISQGQGHSV TYPLGTFILL FNPWSPEDDV 150
    YLPSEILLQE YIMRDYGFVY KGHERFITSW PWNYGQFEED IIDICFEILN 200
    KSLYHLKNPA KDCSQRNDVV YVCRVVSAMI NSNDDNGVLQ GNWGEDYSKG 250
    VSPLEWKGSV AILQQWSARG GQPVKYGQCW VFASVMCTVM RCLGVPTRVV 300
    SNFRSAHNVD RNLTIDTYYD RNAEMLSTQK RDKIWNFHVW NECWMIRKDL 350
    PPGYNGWQVL DPTPQQTSSG LFCCGPASVK AIREGDVHLA YDTPFVYAEV 400
    NADEVIWLLG DGQAQEILAH NTSSIGKEIS TKMVGSDQRQ SITSSYKYPE 450
    GSPEERAVFM KASRKMLGPQ RASLPFLDLL ESGGLRDQPA QLQLHLARIP 500
    EWGQDLQLLL RIQRVPDSTH PRGPIGLVVR FCAQALLHGG GTQKPFWRHT 550
    VRMNLDFGKE TQWPLLLPYS NYRNKLTDEK LIRVSGIAEV EETGRSMLVL 600
    KDICLEPPHL SIEVSERAEV GKALRVHVTL TNTLMVALSS CTMVLEGSGL 650
    INGQIAKDLG TLVAGHTLQI QLDLYPTKAG PRQLQVLISS NEVKEIKGYK 700
    DIFVTVAGAP 710
    Length:710
    Mass (Da):79,941
    Last modified:December 1, 2001 - v1
    Checksum:i046C5ED002563909
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF363393 mRNA. Translation: AAK97573.1.
    CCDSiCCDS32213.1.
    RefSeqiNP_443187.1. NM_052955.2.
    UniGeneiHs.164661.

    Genome annotation databases

    EnsembliENST00000452443; ENSP00000389466; ENSG00000159495.
    GeneIDi116179.
    KEGGihsa:116179.
    UCSCiuc001zrf.1. human.

    Polymorphism databases

    DMDMi20532271.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF363393 mRNA. Translation: AAK97573.1 .
    CCDSi CCDS32213.1.
    RefSeqi NP_443187.1. NM_052955.2.
    UniGenei Hs.164661.

    3D structure databases

    ProteinModelPortali Q96PF1.
    SMRi Q96PF1. Positions 7-702.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    DrugBanki DB00130. L-Glutamine.

    PTM databases

    PhosphoSitei Q96PF1.

    Polymorphism databases

    DMDMi 20532271.

    Proteomic databases

    PaxDbi Q96PF1.
    PRIDEi Q96PF1.

    Protocols and materials databases

    DNASUi 116179.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000452443 ; ENSP00000389466 ; ENSG00000159495 .
    GeneIDi 116179.
    KEGGi hsa:116179.
    UCSCi uc001zrf.1. human.

    Organism-specific databases

    CTDi 116179.
    GeneCardsi GC15M043568.
    HGNCi HGNC:30790. TGM7.
    MIMi 606776. gene.
    neXtProti NX_Q96PF1.
    PharmGKBi PA134870048.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG299687.
    HOGENOMi HOG000231695.
    HOVERGENi HBG004342.
    InParanoidi Q96PF1.
    KOi K05623.
    OMAi RFCAQAL.
    OrthoDBi EOG7WT40M.
    PhylomeDBi Q96PF1.
    TreeFami TF324278.

    Miscellaneous databases

    GenomeRNAii 116179.
    NextBioi 79821.
    PROi Q96PF1.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q96PF1.
    CleanExi HS_TGM7.
    Genevestigatori Q96PF1.

    Family and domain databases

    Gene3Di 2.60.40.10. 3 hits.
    3.90.260.10. 1 hit.
    InterProi IPR023608. Gln_gamma-glutamylTfrase_euk.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR002931. Transglutaminase-like.
    IPR008958. Transglutaminase_C.
    IPR013808. Transglutaminase_CS.
    IPR001102. Transglutaminase_N.
    [Graphical view ]
    PANTHERi PTHR11590. PTHR11590. 1 hit.
    Pfami PF00927. Transglut_C. 1 hit.
    PF01841. Transglut_core. 1 hit.
    PF00868. Transglut_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000459. TGM_EBP42. 1 hit.
    SMARTi SM00460. TGc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49309. SSF49309. 2 hits.
    SSF81296. SSF81296. 1 hit.
    PROSITEi PS00547. TRANSGLUTAMINASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of transglutaminase genes: identification of a transglutaminase gene cluster on human chromosome 15q15. Structure of the gene encoding transglutaminase X and a novel gene family member, transglutaminase Z."
      Grenard P., Bates M.K., Aeschlimann D.
      J. Biol. Chem. 276:33066-33078(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiTGM7_HUMAN
    AccessioniPrimary (citable) accession number: Q96PF1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2002
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3