Q96PF1 (TGM7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein-glutamine gamma-glutamyltransferase Z

Alternative name(s):
Transglutaminase Z
Short name=TG(Z)
Short name=TGZ
Short name=TGase Z
EC=2.3.2.13
Transglutaminase-7
Short name=TGase-7

Gene names

Name:

TGM7

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	710 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.
Catalytic activity	Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH3.
Cofactor	Binds 1 calcium ion per subunit By similarity.
Tissue specificity	Widely expressed.
Sequence similarities	Belongs to the transglutaminase superfamily. Transglutaminase family.

Ontologies

Keywords
Ligand	Calcium Metal-binding
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	peptide cross-linking Inferred from electronic annotation. Source: InterPro
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein-glutamine gamma-glutamyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 710	710	Protein-glutamine gamma-glutamyltransferase Z		PRO_0000213716
Sites
	Active site	279	1	By similarity
	Active site	338	1	By similarity
	Active site	361	1	By similarity
	Metal binding	401	1	Calcium By similarity
	Metal binding	403	1	Calcium By similarity
	Metal binding	450	1	Calcium By similarity
	Metal binding	455	1	Calcium By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q96PF1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 046C5ED002563909	FASTA	710	79,941
	10 20 30 40 50 60 MDQVATLRLE SVDLQSSRNN KEHHTQEMGV KRLTVRRGQP FYLRLSFSRP FQSQNDHITF 70 80 90 100 110 120 VAETGPKPSE LLGTRATFFL TRVQPGNVWS ASDFTIDSNS LQVSLFTPAN AVIGHYTLKI 130 140 150 160 170 180 EISQGQGHSV TYPLGTFILL FNPWSPEDDV YLPSEILLQE YIMRDYGFVY KGHERFITSW 190 200 210 220 230 240 PWNYGQFEED IIDICFEILN KSLYHLKNPA KDCSQRNDVV YVCRVVSAMI NSNDDNGVLQ 250 260 270 280 290 300 GNWGEDYSKG VSPLEWKGSV AILQQWSARG GQPVKYGQCW VFASVMCTVM RCLGVPTRVV 310 320 330 340 350 360 SNFRSAHNVD RNLTIDTYYD RNAEMLSTQK RDKIWNFHVW NECWMIRKDL PPGYNGWQVL 370 380 390 400 410 420 DPTPQQTSSG LFCCGPASVK AIREGDVHLA YDTPFVYAEV NADEVIWLLG DGQAQEILAH 430 440 450 460 470 480 NTSSIGKEIS TKMVGSDQRQ SITSSYKYPE GSPEERAVFM KASRKMLGPQ RASLPFLDLL 490 500 510 520 530 540 ESGGLRDQPA QLQLHLARIP EWGQDLQLLL RIQRVPDSTH PRGPIGLVVR FCAQALLHGG 550 560 570 580 590 600 GTQKPFWRHT VRMNLDFGKE TQWPLLLPYS NYRNKLTDEK LIRVSGIAEV EETGRSMLVL 610 620 630 640 650 660 KDICLEPPHL SIEVSERAEV GKALRVHVTL TNTLMVALSS CTMVLEGSGL INGQIAKDLG 670 680 690 700 710 TLVAGHTLQI QLDLYPTKAG PRQLQVLISS NEVKEIKGYK DIFVTVAGAP

References

[1]

"Evolution of transglutaminase genes: identification of a transglutaminase gene cluster on human chromosome 15q15. Structure of the gene encoding transglutaminase X and a novel gene family member, transglutaminase Z." Grenard P., Bates M.K., Aeschlimann D. J. Biol. Chem. 276:33066-33078(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF363393 mRNA. Translation: AAK97573.1.
IPI	IPI00044409.
RefSeq	NP_443187.1. NM_052955.2.
UniGene	Hs.164661.
3D structure databases
ProteinModelPortal	Q96PF1.
ModBase	Search...
PTM databases
PhosphoSite	Q96PF1.
Polymorphism databases
DMDM	20532271.
Proteomic databases
PaxDb	Q96PF1.
PRIDE	Q96PF1.
Protocols and materials databases
DNASU	116179.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000452443; ENSP00000389466; ENSG00000159495.
GeneID	116179.
KEGG	hsa:116179.
UCSC	uc001zrf.1. human.
Organism-specific databases
CTD	116179.
GeneCards	GC15M043568.
HGNC	HGNC:30790. TGM7.
MIM	606776. gene.
neXtProt	NX_Q96PF1.
PharmGKB	PA134870048.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG299687.
HOGENOM	HOG000231695.
HOVERGEN	HBG004342.
InParanoid	Q96PF1.
KO	K05623.
OMA	RFCAQAL.
OrthoDB	EOG4F7NJG.
PhylomeDB	Q96PF1.
Gene expression databases
Bgee	Q96PF1.
CleanEx	HS_TGM7.
Genevestigator	Q96PF1.
GermOnline	ENSG00000159495. Homo sapiens.
Family and domain databases
Gene3D	2.60.40.10. 3 hits.
InterPro	IPR023608. Gln_gamma-glutamylTfrase_euk. IPR013783. Ig-like_fold. IPR014756. Ig_E-set. IPR002931. Transglutaminase-like. IPR008958. Transglutaminase_C. IPR013808. Transglutaminase_CS. IPR001102. Transglutaminase_N. [Graphical view]
PANTHER	PTHR11590. PTHR11590. 1 hit.
Pfam	PF00927. Transglut_C. 1 hit. PF01841. Transglut_core. 1 hit. PF00868. Transglut_N. 1 hit. [Graphical view]
PIRSF	PIRSF000459. TGM_EBP42. 1 hit.
SMART	SM00460. TGc. 1 hit. [Graphical view]
SUPFAM	SSF81296. Ig_E-set. 1 hit. SSF49309. Transglut_C. 2 hits.
PROSITE	PS00547. TRANSGLUTAMINASES. 1 hit. [Graphical view]
ProtoNet	Search...
Other
DrugBank	DB00130. L-Glutamine.
GenomeRNAi	116179.
NextBio	79821.
SOURCE	Search...

Entry information

Entry name

TGM7_HUMAN

Accession

Primary (citable) accession number: Q96PF1

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2002
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 99 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.