Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger imprinted 3

Gene

ZIM3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri167 – 18923C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri195 – 21723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri223 – 24523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri251 – 27323C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri279 – 30123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri307 – 32923C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri335 – 35723C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri363 – 38523C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri391 – 41323C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri419 – 44123C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri447 – 47024C2H2-type 11PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger imprinted 3
Alternative name(s):
Zinc finger protein 657
Gene namesi
Name:ZIM3
Synonyms:ZNF657
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:16366. ZIM3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38127.

Polymorphism and mutation databases

BioMutaiZIM3.
DMDMi20141013.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 472472Zinc finger imprinted 3PRO_0000047775Add
BLAST

Proteomic databases

EPDiQ96PE6.
PaxDbiQ96PE6.
PRIDEiQ96PE6.

PTM databases

iPTMnetiQ96PE6.
PhosphoSiteiQ96PE6.

Expressioni

Gene expression databases

CleanExiHS_ZIM3.
GenevisibleiQ96PE6. HS.

Organism-specific databases

HPAiHPA034575.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000269834.

Structurei

3D structure databases

ProteinModelPortaliQ96PE6.
SMRiQ96PE6. Positions 8-48, 132-472.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 8073KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 11 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri167 – 18923C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri195 – 21723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri223 – 24523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri251 – 27323C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri279 – 30123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri307 – 32923C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri335 – 35723C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri363 – 38523C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri391 – 41323C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri419 – 44123C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri447 – 47024C2H2-type 11PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129857.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ96PE6.
KOiK09228.
OMAiCINHEKI.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ96PE6.
TreeFamiTF337055.

Family and domain databases

Gene3Di3.30.160.60. 11 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 11 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96PE6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNSQGRVTF EDVTVNFTQG EWQRLNPEQR NLYRDVMLEN YSNLVSVGQG
60 70 80 90 100
ETTKPDVILR LEQGKEPWLE EEEVLGSGRA EKNGDIGGQI WKPKDVKESL
110 120 130 140 150
AREVPSINKE TLTTQKGVEC DGSKKILPLG IDDVSSLQHY VQNNSHDDNG
160 170 180 190 200
YRKLVGNNPS KFVGQQLKCN ACRKLFSSKS RLQSHLRRHA CQKPFECHSC
210 220 230 240 250
GRAFGEKWKL DKHQKTHAEE RPYKCENCGN AYKQKSNLFQ HQKMHTKEKP
260 270 280 290 300
YQCKTCGKAF SWKSSCINHE KIHNAKKSYQ CNECEKSFRQ NSTLIQHKKV
310 320 330 340 350
HTGQKPFQCT DCGKAFIYKS DLVKHQRIHT GEKPYKCSIC EKAFSQKSNV
360 370 380 390 400
IDHEKIHTGK RAYECDLCGN TFIQKKNLIQ HKKIHTGEKP YECNRCGKAF
410 420 430 440 450
FQKSNLHSHQ KTHSGERTYR CSECGKTFIR KLNLSLHKKT HTGQKPYGCS
460 470
ECGKAFADRS YLVRHQKRIH SR
Length:472
Mass (Da):54,498
Last modified:December 1, 2001 - v1
Checksum:i755279B78653F286
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti7 – 71R → K.
Corresponds to variant rs10407445 [ dbSNP | Ensembl ].
VAR_024222
Natural varianti28 – 281E → K.
Corresponds to variant rs2370134 [ dbSNP | Ensembl ].
VAR_024223
Natural varianti69 – 691L → M.
Corresponds to variant rs4801200 [ dbSNP | Ensembl ].
VAR_033599
Natural varianti157 – 1571N → D.
Corresponds to variant rs7252632 [ dbSNP | Ensembl ].
VAR_024224
Natural varianti205 – 2051G → R.
Corresponds to variant rs35202951 [ dbSNP | Ensembl ].
VAR_052933
Natural varianti379 – 3791I → V.
Corresponds to variant rs4801433 [ dbSNP | Ensembl ].
VAR_024225

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF365931 mRNA. Translation: AAL11635.1.
BC114446 mRNA. Translation: AAI14447.1.
BC114503 mRNA. Translation: AAI14504.1.
CCDSiCCDS33125.1.
RefSeqiNP_443114.1. NM_052882.1.
UniGeneiHs.348622.

Genome annotation databases

EnsembliENST00000269834; ENSP00000269834; ENSG00000141946.
GeneIDi114026.
KEGGihsa:114026.
UCSCiuc002qnz.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF365931 mRNA. Translation: AAL11635.1.
BC114446 mRNA. Translation: AAI14447.1.
BC114503 mRNA. Translation: AAI14504.1.
CCDSiCCDS33125.1.
RefSeqiNP_443114.1. NM_052882.1.
UniGeneiHs.348622.

3D structure databases

ProteinModelPortaliQ96PE6.
SMRiQ96PE6. Positions 8-48, 132-472.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000269834.

PTM databases

iPTMnetiQ96PE6.
PhosphoSiteiQ96PE6.

Polymorphism and mutation databases

BioMutaiZIM3.
DMDMi20141013.

Proteomic databases

EPDiQ96PE6.
PaxDbiQ96PE6.
PRIDEiQ96PE6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000269834; ENSP00000269834; ENSG00000141946.
GeneIDi114026.
KEGGihsa:114026.
UCSCiuc002qnz.1. human.

Organism-specific databases

CTDi114026.
GeneCardsiZIM3.
HGNCiHGNC:16366. ZIM3.
HPAiHPA034575.
neXtProtiNX_Q96PE6.
PharmGKBiPA38127.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129857.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ96PE6.
KOiK09228.
OMAiCINHEKI.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ96PE6.
TreeFamiTF337055.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii114026.
PROiQ96PE6.

Gene expression databases

CleanExiHS_ZIM3.
GenevisibleiQ96PE6. HS.

Family and domain databases

Gene3Di3.30.160.60. 11 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 11 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Imprinting and evolution of two Kruppel-type zinc-finger genes, ZIM3 and ZNF264, located in the PEG3/USP29 imprinted domain."
    Kim J., Bergmann A., Wehri E., Lu X., Stubbs L.
    Genomics 77:91-98(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiZIM3_HUMAN
AccessioniPrimary (citable) accession number: Q96PE6
Secondary accession number(s): Q14CA6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: December 1, 2001
Last modified: June 8, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.