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Q96PE2

- ARHGH_HUMAN

UniProt

Q96PE2 - ARHGH_HUMAN

Protein

Rho guanine nucleotide exchange factor 17

Gene

ARHGEF17

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases.1 Publication

    GO - Molecular functioni

    1. guanyl-nucleotide exchange factor activity Source: MGI
    2. Rho guanyl-nucleotide exchange factor activity Source: InterPro

    GO - Biological processi

    1. actin cytoskeleton organization Source: MGI
    2. apoptotic signaling pathway Source: Reactome
    3. neurotrophin TRK receptor signaling pathway Source: Reactome
    4. positive regulation of apoptotic process Source: Reactome
    5. positive regulation of GTPase activity Source: GOC
    6. regulation of small GTPase mediated signal transduction Source: Reactome
    7. small GTPase mediated signal transduction Source: Reactome

    Keywords - Molecular functioni

    Guanine-nucleotide releasing factor

    Enzyme and pathway databases

    ReactomeiREACT_11051. Rho GTPase cycle.
    REACT_13638. NRAGE signals death through JNK.
    REACT_18407. G alpha (12/13) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Rho guanine nucleotide exchange factor 17
    Alternative name(s):
    164 kDa Rho-specific guanine-nucleotide exchange factor
    Short name:
    p164-RhoGEF
    Short name:
    p164RhoGEF
    Tumor endothelial marker 4
    Gene namesi
    Name:ARHGEF17
    Synonyms:KIAA0337, TEM4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:21726. ARHGEF17.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Reactome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134884537.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 20632063Rho guanine nucleotide exchange factor 17PRO_0000286589Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei461 – 4611Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ96PE2.
    PaxDbiQ96PE2.
    PRIDEiQ96PE2.

    PTM databases

    PhosphoSiteiQ96PE2.

    Expressioni

    Tissue specificityi

    Highly expressed in the heart.1 Publication

    Gene expression databases

    BgeeiQ96PE2.
    CleanExiHS_ARHGEF17.
    GenevestigatoriQ96PE2.

    Organism-specific databases

    HPAiHPA007991.

    Interactioni

    Protein-protein interaction databases

    BioGridi115166. 2 interactions.
    IntActiQ96PE2. 2 interactions.
    MINTiMINT-3974886.
    STRINGi9606.ENSP00000263674.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96PE2.
    SMRiQ96PE2. Positions 1067-1385.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1066 – 1254189DHPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi201 – 2044Poly-Gln
    Compositional biasi230 – 2356Poly-Ser
    Compositional biasi252 – 2565Poly-Glu
    Compositional biasi566 – 5694Poly-Ser
    Compositional biasi672 – 6754Poly-Ser
    Compositional biasi707 – 7104Poly-Arg
    Compositional biasi963 – 105492Pro-richAdd
    BLAST
    Compositional biasi1990 – 19967Poly-Pro

    Sequence similaritiesi

    Contains 1 DH (DBL-homology) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG312337.
    HOGENOMiHOG000034048.
    HOVERGENiHBG095607.
    InParanoidiQ96PE2.
    OMAiMGAQQDD.
    OrthoDBiEOG7P2XR5.
    PhylomeDBiQ96PE2.
    TreeFamiTF324157.

    Family and domain databases

    Gene3Di1.20.900.10. 1 hit.
    2.130.10.10. 1 hit.
    2.30.29.30. 1 hit.
    InterProiIPR000219. DH-domain.
    IPR011993. PH_like_dom.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF00621. RhoGEF. 1 hit.
    [Graphical view]
    SMARTiSM00325. RhoGEF. 1 hit.
    [Graphical view]
    SUPFAMiSSF48065. SSF48065. 1 hit.
    SSF50978. SSF50978. 1 hit.
    PROSITEiPS50010. DH_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96PE2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADGAPRPQL YRSVSFKLLE RWSGGPGLRE EDTDTPGLRR RASCRPTTAA     50
    RGQPSRRVSK LASGPLAAPA QPRPLRSLSP SVRQLSRRFD APRLDDGSAG 100
    TRDGGVLPAA AEEAAEGPAR GAWPSVTEMR KLFGGPGSRR PSADSESPGT 150
    PSPDGAAWEP PARESRQPPT PPPRTCFPLA GLRSARPLTG PETEGRLRRP 200
    QQQQERAQRP ADGLHSWHIF SQPQAGARAS CSSSSIAASY PVSRSRAASS 250
    SEEEEEGPPQ LPGAQSPAYH GGHSSGSDDD RDGEGGHRWG GRPGLRPGSS 300
    LLDQDCRPDS DGLNLSSMNS AGVSGSPEPP TSPRAPREEG LREWGSGSPP 350
    CVPGPQEGLR PMSDSVGGAF RVAKVSFPSY LASPAGSRGS SRYSSTETLK 400
    DDDLWSSRGS GGWGVYRSPS FGAGEGLLRS QARTRAKGPG GTSRALRDGG 450
    FEPEKSRQRK SLSNPDIASE TLTLLSFLRS DLSELRVRKP GGSSGDRGSN 500
    PLDGRDSPSA GGPVGQLEPI PIPAPASPGT RPTLKDLTAT LRRAKSFTCS 550
    EKPMARRLPR TSALKSSSSE LLLTGPGAEE DPLPLIVQDQ YVQEARQVFE 600
    KIQRMGAQQD DGSDAPPGSP DWAGDVTRGQ RSQEELSGPE SSLTDEGIGA 650
    DPEPPVAAFC GLGTTGMWRP LSSSSAQTNH HGPGTEDSLG GWALVSPETP 700
    PTPGALRRRR KVPPSGSGGS ELSNGEAGEA YRSLSDPIPQ RHRAATSEEP 750
    TGFSVDSNLL GSLSPKTGLP ATSAMDEGLT SGHSDWSVGS EESKGYQEVI 800
    QSIVQGPGTL GRVVDDRIAG KAPKKKSLSD PSRRGELAGP GFEGPGGEPI 850
    REVEPMLPPS SSEPILVEQR AEPEEPGATR SRAQSERALP EALPPPATAH 900
    RNFHLDPKLA DILSPRLIRR GSKKRPARSS HQELRRDEGS QDQTGSLSRA 950
    RPSSRHVRHA SVPATFMPIV VPEPPTSVGP PVAVPEPIGF PTRAHPTLQA 1000
    PSLEDVTKQY MLNLHSGEVP APVPVDMPCL PLAAPPSAEA KPPEAARPAD 1050
    EPTPASKCCS KPQVDMRKHV AMTLLDTEQS YVESLRTLMQ GYMQPLKQPE 1100
    NSVLCDPSLV DEIFDQIPEL LEHHEQFLEQ VRHCMQTWHA QQKVGALLVQ 1150
    SFSKDVLVNI YSAYIDNFLN AKDAVRVAKE ARPAFLKFLE QSMRENKEKQ 1200
    ALSDLMIKPV QRIPRYELLV KDLLKHTPED HPDHPLLLEA QRNIKQVAER 1250
    INKGVRSAEE AERHARVLQE IEAHIEGMED LQAPLRRFLR QEMVIEVKAI 1300
    GGKKDRSLFL FTDLIVCTTL KRKSGSLRRS SMSLYTAASV IDTASKYKML 1350
    WKLPLEDADI IKGASQATNR ENIQKAISRL DEDLTTLGQM SKLSESLGFP 1400
    HQSLDDALRD LSAAMHRDLS EKQALCYALS FPPTKLELCA TRPEGTDSYI 1450
    FEFPHPDARL GFEQAFDEAK RKLASSKSCL DPEFLKAIPI MKTRSGMQFS 1500
    CAAPTLNSCP EPSPEVWVCN SDGYVGQVCL LSLRAEPDVE ACIAVCSARI 1550
    LCIGAVPGLQ PRCHREPPPS LRSPPETAPE PAGPELDVEA AADEEAATLA 1600
    EPGPQPCLHI SIAGSGLEMT PGLGEGDPRP ELVPFDSDSD DESSPSPSGT 1650
    LQSQASRSTI SSSFGNEETP SSKEATAETT SSEEEQEPGF LPLSGSFGPG 1700
    GPCGTSPMDG RALRRSSHGS FTRGSLEDLL SVDPEAYQSS VWLGTEDGCV 1750
    HVYQSSDSIR DRRNSMKLQH AASVTCILYL NNQVFVSLAN GELVVYQREA 1800
    GHFWDPQNFK SVTLGTQGSP ITKMVSVGGR LWCGCQNRVL VLSPDTLQLE 1850
    HMFYVGQDSS RCVACMVDSS LGVWVTLKGS AHVCLYHPDT FEQLAEVDVT 1900
    PPVHRMLAGS DAIIRQHKAA CLRITALLVC EELLWVGTSA GVVLTMPTSP 1950
    GTVSCPRAPL SPTGLGQGHT GHVRFLAAVQ LPDGFNLLCP TPPPPPDTGP 2000
    EKLPSLEHRD SPWHRGPAPA RPKMLVISGG DGYEDFRLSS GGGSSSETVG 2050
    RDDSTNHLLL WRV 2063
    Length:2,063
    Mass (Da):221,673
    Last modified:December 1, 2001 - v1
    Checksum:i76A53FF6CBF5F5C0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti722 – 7221L → F in BAA20795. (PubMed:9205841)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti450 – 4501G → E.
    Corresponds to variant rs3741150 [ dbSNP | Ensembl ].
    VAR_032132
    Natural varianti1465 – 14651A → D.
    Corresponds to variant rs2298808 [ dbSNP | Ensembl ].
    VAR_032133

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF378754 mRNA. Translation: AAL11991.1.
    CH471076 Genomic DNA. Translation: EAW74891.1.
    BC050031 mRNA. Translation: AAH50031.1.
    BC137228 mRNA. Translation: AAI37229.1.
    AK074500 mRNA. No translation available.
    AB002335 mRNA. Translation: BAA20795.2.
    CCDSiCCDS8221.1.
    RefSeqiNP_055601.2. NM_014786.3.
    UniGeneiHs.533719.
    Hs.573929.

    Genome annotation databases

    EnsembliENST00000263674; ENSP00000263674; ENSG00000110237.
    GeneIDi9828.
    KEGGihsa:9828.
    UCSCiuc001otu.3. human.

    Polymorphism databases

    DMDMi74724250.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF378754 mRNA. Translation: AAL11991.1 .
    CH471076 Genomic DNA. Translation: EAW74891.1 .
    BC050031 mRNA. Translation: AAH50031.1 .
    BC137228 mRNA. Translation: AAI37229.1 .
    AK074500 mRNA. No translation available.
    AB002335 mRNA. Translation: BAA20795.2 .
    CCDSi CCDS8221.1.
    RefSeqi NP_055601.2. NM_014786.3.
    UniGenei Hs.533719.
    Hs.573929.

    3D structure databases

    ProteinModelPortali Q96PE2.
    SMRi Q96PE2. Positions 1067-1385.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115166. 2 interactions.
    IntActi Q96PE2. 2 interactions.
    MINTi MINT-3974886.
    STRINGi 9606.ENSP00000263674.

    PTM databases

    PhosphoSitei Q96PE2.

    Polymorphism databases

    DMDMi 74724250.

    Proteomic databases

    MaxQBi Q96PE2.
    PaxDbi Q96PE2.
    PRIDEi Q96PE2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000263674 ; ENSP00000263674 ; ENSG00000110237 .
    GeneIDi 9828.
    KEGGi hsa:9828.
    UCSCi uc001otu.3. human.

    Organism-specific databases

    CTDi 9828.
    GeneCardsi GC11P073019.
    H-InvDB HIX0171270.
    HGNCi HGNC:21726. ARHGEF17.
    HPAi HPA007991.
    neXtProti NX_Q96PE2.
    PharmGKBi PA134884537.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG312337.
    HOGENOMi HOG000034048.
    HOVERGENi HBG095607.
    InParanoidi Q96PE2.
    OMAi MGAQQDD.
    OrthoDBi EOG7P2XR5.
    PhylomeDBi Q96PE2.
    TreeFami TF324157.

    Enzyme and pathway databases

    Reactomei REACT_11051. Rho GTPase cycle.
    REACT_13638. NRAGE signals death through JNK.
    REACT_18407. G alpha (12/13) signalling events.

    Miscellaneous databases

    GenomeRNAii 9828.
    NextBioi 37026.
    PROi Q96PE2.

    Gene expression databases

    Bgeei Q96PE2.
    CleanExi HS_ARHGEF17.
    Genevestigatori Q96PE2.

    Family and domain databases

    Gene3Di 1.20.900.10. 1 hit.
    2.130.10.10. 1 hit.
    2.30.29.30. 1 hit.
    InterProi IPR000219. DH-domain.
    IPR011993. PH_like_dom.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF00621. RhoGEF. 1 hit.
    [Graphical view ]
    SMARTi SM00325. RhoGEF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48065. SSF48065. 1 hit.
    SSF50978. SSF50978. 1 hit.
    PROSITEi PS50010. DH_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cell surface tumor endothelial markers are conserved in mice and humans."
      Carson-Walter E.B., Watkins D.N., Nanda A., Vogelstein B., Kinzler K.W., St Croix B.
      Cancer Res. 61:6649-6655(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain and Colon.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-401.
      Tissue: Embryo.
    5. "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
      Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 455-2063.
      Tissue: Brain.
    6. "A mammalian Rho-specific guanine-nucleotide exchange factor (p164-RhoGEF) without a pleckstrin homology domain."
      Ruemenapp U., Freichel-Blomquist A., Wittinghofer B., Jakobs K.H., Wieland T.
      Biochem. J. 366:721-728(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-461, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiARHGH_HUMAN
    AccessioniPrimary (citable) accession number: Q96PE2
    Secondary accession number(s): B2RP20
    , Q86XU2, Q8N2S0, Q9Y4G3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 15, 2007
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3