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Q96PE2

- ARHGH_HUMAN

UniProt

Q96PE2 - ARHGH_HUMAN

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Protein
Rho guanine nucleotide exchange factor 17
Gene
ARHGEF17, KIAA0337, TEM4
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases.1 Publication

GO - Molecular functioni

  1. Rho guanyl-nucleotide exchange factor activity Source: InterPro
  2. guanyl-nucleotide exchange factor activity Source: MGI

GO - Biological processi

  1. actin cytoskeleton organization Source: MGI
  2. apoptotic signaling pathway Source: Reactome
  3. neurotrophin TRK receptor signaling pathway Source: Reactome
  4. positive regulation of apoptotic process Source: Reactome
  5. regulation of GTPase activity Source: GOC
  6. regulation of small GTPase mediated signal transduction Source: Reactome
  7. small GTPase mediated signal transduction Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Enzyme and pathway databases

ReactomeiREACT_11051. Rho GTPase cycle.
REACT_13638. NRAGE signals death through JNK.
REACT_18407. G alpha (12/13) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Rho guanine nucleotide exchange factor 17
Alternative name(s):
164 kDa Rho-specific guanine-nucleotide exchange factor
Short name:
p164-RhoGEF
Short name:
p164RhoGEF
Tumor endothelial marker 4
Gene namesi
Synonyms:KIAA0337, TEM4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:21726. ARHGEF17.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Reactome
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134884537.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 20632063Rho guanine nucleotide exchange factor 17
PRO_0000286589Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei461 – 4611Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ96PE2.
PaxDbiQ96PE2.
PRIDEiQ96PE2.

PTM databases

PhosphoSiteiQ96PE2.

Expressioni

Tissue specificityi

Highly expressed in the heart.1 Publication

Gene expression databases

BgeeiQ96PE2.
CleanExiHS_ARHGEF17.
GenevestigatoriQ96PE2.

Organism-specific databases

HPAiHPA007991.

Interactioni

Protein-protein interaction databases

BioGridi115166. 2 interactions.
IntActiQ96PE2. 2 interactions.
MINTiMINT-3974886.
STRINGi9606.ENSP00000263674.

Structurei

3D structure databases

ProteinModelPortaliQ96PE2.
SMRiQ96PE2. Positions 1067-1385.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1066 – 1254189DH
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi201 – 2044Poly-Gln
Compositional biasi230 – 2356Poly-Ser
Compositional biasi252 – 2565Poly-Glu
Compositional biasi566 – 5694Poly-Ser
Compositional biasi672 – 6754Poly-Ser
Compositional biasi707 – 7104Poly-Arg
Compositional biasi963 – 105492Pro-rich
Add
BLAST
Compositional biasi1990 – 19967Poly-Pro

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG312337.
HOGENOMiHOG000034048.
HOVERGENiHBG095607.
InParanoidiQ96PE2.
OMAiMGAQQDD.
OrthoDBiEOG7P2XR5.
PhylomeDBiQ96PE2.
TreeFamiTF324157.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.130.10.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR000219. DH-domain.
IPR011993. PH_like_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50978. SSF50978. 1 hit.
PROSITEiPS50010. DH_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96PE2-1 [UniParc]FASTAAdd to Basket

« Hide

MADGAPRPQL YRSVSFKLLE RWSGGPGLRE EDTDTPGLRR RASCRPTTAA     50
RGQPSRRVSK LASGPLAAPA QPRPLRSLSP SVRQLSRRFD APRLDDGSAG 100
TRDGGVLPAA AEEAAEGPAR GAWPSVTEMR KLFGGPGSRR PSADSESPGT 150
PSPDGAAWEP PARESRQPPT PPPRTCFPLA GLRSARPLTG PETEGRLRRP 200
QQQQERAQRP ADGLHSWHIF SQPQAGARAS CSSSSIAASY PVSRSRAASS 250
SEEEEEGPPQ LPGAQSPAYH GGHSSGSDDD RDGEGGHRWG GRPGLRPGSS 300
LLDQDCRPDS DGLNLSSMNS AGVSGSPEPP TSPRAPREEG LREWGSGSPP 350
CVPGPQEGLR PMSDSVGGAF RVAKVSFPSY LASPAGSRGS SRYSSTETLK 400
DDDLWSSRGS GGWGVYRSPS FGAGEGLLRS QARTRAKGPG GTSRALRDGG 450
FEPEKSRQRK SLSNPDIASE TLTLLSFLRS DLSELRVRKP GGSSGDRGSN 500
PLDGRDSPSA GGPVGQLEPI PIPAPASPGT RPTLKDLTAT LRRAKSFTCS 550
EKPMARRLPR TSALKSSSSE LLLTGPGAEE DPLPLIVQDQ YVQEARQVFE 600
KIQRMGAQQD DGSDAPPGSP DWAGDVTRGQ RSQEELSGPE SSLTDEGIGA 650
DPEPPVAAFC GLGTTGMWRP LSSSSAQTNH HGPGTEDSLG GWALVSPETP 700
PTPGALRRRR KVPPSGSGGS ELSNGEAGEA YRSLSDPIPQ RHRAATSEEP 750
TGFSVDSNLL GSLSPKTGLP ATSAMDEGLT SGHSDWSVGS EESKGYQEVI 800
QSIVQGPGTL GRVVDDRIAG KAPKKKSLSD PSRRGELAGP GFEGPGGEPI 850
REVEPMLPPS SSEPILVEQR AEPEEPGATR SRAQSERALP EALPPPATAH 900
RNFHLDPKLA DILSPRLIRR GSKKRPARSS HQELRRDEGS QDQTGSLSRA 950
RPSSRHVRHA SVPATFMPIV VPEPPTSVGP PVAVPEPIGF PTRAHPTLQA 1000
PSLEDVTKQY MLNLHSGEVP APVPVDMPCL PLAAPPSAEA KPPEAARPAD 1050
EPTPASKCCS KPQVDMRKHV AMTLLDTEQS YVESLRTLMQ GYMQPLKQPE 1100
NSVLCDPSLV DEIFDQIPEL LEHHEQFLEQ VRHCMQTWHA QQKVGALLVQ 1150
SFSKDVLVNI YSAYIDNFLN AKDAVRVAKE ARPAFLKFLE QSMRENKEKQ 1200
ALSDLMIKPV QRIPRYELLV KDLLKHTPED HPDHPLLLEA QRNIKQVAER 1250
INKGVRSAEE AERHARVLQE IEAHIEGMED LQAPLRRFLR QEMVIEVKAI 1300
GGKKDRSLFL FTDLIVCTTL KRKSGSLRRS SMSLYTAASV IDTASKYKML 1350
WKLPLEDADI IKGASQATNR ENIQKAISRL DEDLTTLGQM SKLSESLGFP 1400
HQSLDDALRD LSAAMHRDLS EKQALCYALS FPPTKLELCA TRPEGTDSYI 1450
FEFPHPDARL GFEQAFDEAK RKLASSKSCL DPEFLKAIPI MKTRSGMQFS 1500
CAAPTLNSCP EPSPEVWVCN SDGYVGQVCL LSLRAEPDVE ACIAVCSARI 1550
LCIGAVPGLQ PRCHREPPPS LRSPPETAPE PAGPELDVEA AADEEAATLA 1600
EPGPQPCLHI SIAGSGLEMT PGLGEGDPRP ELVPFDSDSD DESSPSPSGT 1650
LQSQASRSTI SSSFGNEETP SSKEATAETT SSEEEQEPGF LPLSGSFGPG 1700
GPCGTSPMDG RALRRSSHGS FTRGSLEDLL SVDPEAYQSS VWLGTEDGCV 1750
HVYQSSDSIR DRRNSMKLQH AASVTCILYL NNQVFVSLAN GELVVYQREA 1800
GHFWDPQNFK SVTLGTQGSP ITKMVSVGGR LWCGCQNRVL VLSPDTLQLE 1850
HMFYVGQDSS RCVACMVDSS LGVWVTLKGS AHVCLYHPDT FEQLAEVDVT 1900
PPVHRMLAGS DAIIRQHKAA CLRITALLVC EELLWVGTSA GVVLTMPTSP 1950
GTVSCPRAPL SPTGLGQGHT GHVRFLAAVQ LPDGFNLLCP TPPPPPDTGP 2000
EKLPSLEHRD SPWHRGPAPA RPKMLVISGG DGYEDFRLSS GGGSSSETVG 2050
RDDSTNHLLL WRV 2063
Length:2,063
Mass (Da):221,673
Last modified:December 1, 2001 - v1
Checksum:i76A53FF6CBF5F5C0
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti450 – 4501G → E.
Corresponds to variant rs3741150 [ dbSNP | Ensembl ].
VAR_032132
Natural varianti1465 – 14651A → D.
Corresponds to variant rs2298808 [ dbSNP | Ensembl ].
VAR_032133

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti722 – 7221L → F in BAA20795. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF378754 mRNA. Translation: AAL11991.1.
CH471076 Genomic DNA. Translation: EAW74891.1.
BC050031 mRNA. Translation: AAH50031.1.
BC137228 mRNA. Translation: AAI37229.1.
AK074500 mRNA. No translation available.
AB002335 mRNA. Translation: BAA20795.2.
CCDSiCCDS8221.1.
RefSeqiNP_055601.2. NM_014786.3.
UniGeneiHs.533719.
Hs.573929.

Genome annotation databases

EnsembliENST00000263674; ENSP00000263674; ENSG00000110237.
GeneIDi9828.
KEGGihsa:9828.
UCSCiuc001otu.3. human.

Polymorphism databases

DMDMi74724250.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF378754 mRNA. Translation: AAL11991.1 .
CH471076 Genomic DNA. Translation: EAW74891.1 .
BC050031 mRNA. Translation: AAH50031.1 .
BC137228 mRNA. Translation: AAI37229.1 .
AK074500 mRNA. No translation available.
AB002335 mRNA. Translation: BAA20795.2 .
CCDSi CCDS8221.1.
RefSeqi NP_055601.2. NM_014786.3.
UniGenei Hs.533719.
Hs.573929.

3D structure databases

ProteinModelPortali Q96PE2.
SMRi Q96PE2. Positions 1067-1385.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115166. 2 interactions.
IntActi Q96PE2. 2 interactions.
MINTi MINT-3974886.
STRINGi 9606.ENSP00000263674.

PTM databases

PhosphoSitei Q96PE2.

Polymorphism databases

DMDMi 74724250.

Proteomic databases

MaxQBi Q96PE2.
PaxDbi Q96PE2.
PRIDEi Q96PE2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000263674 ; ENSP00000263674 ; ENSG00000110237 .
GeneIDi 9828.
KEGGi hsa:9828.
UCSCi uc001otu.3. human.

Organism-specific databases

CTDi 9828.
GeneCardsi GC11P073019.
H-InvDB HIX0171270.
HGNCi HGNC:21726. ARHGEF17.
HPAi HPA007991.
neXtProti NX_Q96PE2.
PharmGKBi PA134884537.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG312337.
HOGENOMi HOG000034048.
HOVERGENi HBG095607.
InParanoidi Q96PE2.
OMAi MGAQQDD.
OrthoDBi EOG7P2XR5.
PhylomeDBi Q96PE2.
TreeFami TF324157.

Enzyme and pathway databases

Reactomei REACT_11051. Rho GTPase cycle.
REACT_13638. NRAGE signals death through JNK.
REACT_18407. G alpha (12/13) signalling events.

Miscellaneous databases

GenomeRNAii 9828.
NextBioi 37026.
PROi Q96PE2.

Gene expression databases

Bgeei Q96PE2.
CleanExi HS_ARHGEF17.
Genevestigatori Q96PE2.

Family and domain databases

Gene3Di 1.20.900.10. 1 hit.
2.130.10.10. 1 hit.
2.30.29.30. 1 hit.
InterProi IPR000219. DH-domain.
IPR011993. PH_like_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF00621. RhoGEF. 1 hit.
[Graphical view ]
SMARTi SM00325. RhoGEF. 1 hit.
[Graphical view ]
SUPFAMi SSF48065. SSF48065. 1 hit.
SSF50978. SSF50978. 1 hit.
PROSITEi PS50010. DH_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cell surface tumor endothelial markers are conserved in mice and humans."
    Carson-Walter E.B., Watkins D.N., Nanda A., Vogelstein B., Kinzler K.W., St Croix B.
    Cancer Res. 61:6649-6655(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Colon.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-401.
    Tissue: Embryo.
  5. "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 455-2063.
    Tissue: Brain.
  6. "A mammalian Rho-specific guanine-nucleotide exchange factor (p164-RhoGEF) without a pleckstrin homology domain."
    Ruemenapp U., Freichel-Blomquist A., Wittinghofer B., Jakobs K.H., Wieland T.
    Biochem. J. 366:721-728(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-461, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiARHGH_HUMAN
AccessioniPrimary (citable) accession number: Q96PE2
Secondary accession number(s): B2RP20
, Q86XU2, Q8N2S0, Q9Y4G3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: December 1, 2001
Last modified: September 3, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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