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Q96PE2 (ARHGH_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Rho guanine nucleotide exchange factor 17
Alternative name(s):
164 kDa Rho-specific guanine-nucleotide exchange factor
Short name=p164-RhoGEF
Short name=p164RhoGEF
Tumor endothelial marker 4
Gene names
Name:ARHGEF17
Synonyms:KIAA0337, TEM4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length2063 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. Ref.6

Tissue specificity

Highly expressed in the heart. Ref.6

Sequence similarities

Contains 1 DH (DBL-homology) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 20632063Rho guanine nucleotide exchange factor 17
PRO_0000286589

Regions

Domain1066 – 1254189DH
Compositional bias201 – 2044Poly-Gln
Compositional bias230 – 2356Poly-Ser
Compositional bias252 – 2565Poly-Glu
Compositional bias566 – 5694Poly-Ser
Compositional bias672 – 6754Poly-Ser
Compositional bias707 – 7104Poly-Arg
Compositional bias963 – 105492Pro-rich
Compositional bias1990 – 19967Poly-Pro

Amino acid modifications

Modified residue4611Phosphoserine Ref.8

Natural variations

Natural variant4501G → E.
Corresponds to variant rs3741150 [ dbSNP | Ensembl ].
VAR_032132
Natural variant14651A → D.
Corresponds to variant rs2298808 [ dbSNP | Ensembl ].
VAR_032133

Experimental info

Sequence conflict7221L → F in BAA20795. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Q96PE2 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 76A53FF6CBF5F5C0

FASTA2,063221,673
        10         20         30         40         50         60 
MADGAPRPQL YRSVSFKLLE RWSGGPGLRE EDTDTPGLRR RASCRPTTAA RGQPSRRVSK 

        70         80         90        100        110        120 
LASGPLAAPA QPRPLRSLSP SVRQLSRRFD APRLDDGSAG TRDGGVLPAA AEEAAEGPAR 

       130        140        150        160        170        180 
GAWPSVTEMR KLFGGPGSRR PSADSESPGT PSPDGAAWEP PARESRQPPT PPPRTCFPLA 

       190        200        210        220        230        240 
GLRSARPLTG PETEGRLRRP QQQQERAQRP ADGLHSWHIF SQPQAGARAS CSSSSIAASY 

       250        260        270        280        290        300 
PVSRSRAASS SEEEEEGPPQ LPGAQSPAYH GGHSSGSDDD RDGEGGHRWG GRPGLRPGSS 

       310        320        330        340        350        360 
LLDQDCRPDS DGLNLSSMNS AGVSGSPEPP TSPRAPREEG LREWGSGSPP CVPGPQEGLR 

       370        380        390        400        410        420 
PMSDSVGGAF RVAKVSFPSY LASPAGSRGS SRYSSTETLK DDDLWSSRGS GGWGVYRSPS 

       430        440        450        460        470        480 
FGAGEGLLRS QARTRAKGPG GTSRALRDGG FEPEKSRQRK SLSNPDIASE TLTLLSFLRS 

       490        500        510        520        530        540 
DLSELRVRKP GGSSGDRGSN PLDGRDSPSA GGPVGQLEPI PIPAPASPGT RPTLKDLTAT 

       550        560        570        580        590        600 
LRRAKSFTCS EKPMARRLPR TSALKSSSSE LLLTGPGAEE DPLPLIVQDQ YVQEARQVFE 

       610        620        630        640        650        660 
KIQRMGAQQD DGSDAPPGSP DWAGDVTRGQ RSQEELSGPE SSLTDEGIGA DPEPPVAAFC 

       670        680        690        700        710        720 
GLGTTGMWRP LSSSSAQTNH HGPGTEDSLG GWALVSPETP PTPGALRRRR KVPPSGSGGS 

       730        740        750        760        770        780 
ELSNGEAGEA YRSLSDPIPQ RHRAATSEEP TGFSVDSNLL GSLSPKTGLP ATSAMDEGLT 

       790        800        810        820        830        840 
SGHSDWSVGS EESKGYQEVI QSIVQGPGTL GRVVDDRIAG KAPKKKSLSD PSRRGELAGP 

       850        860        870        880        890        900 
GFEGPGGEPI REVEPMLPPS SSEPILVEQR AEPEEPGATR SRAQSERALP EALPPPATAH 

       910        920        930        940        950        960 
RNFHLDPKLA DILSPRLIRR GSKKRPARSS HQELRRDEGS QDQTGSLSRA RPSSRHVRHA 

       970        980        990       1000       1010       1020 
SVPATFMPIV VPEPPTSVGP PVAVPEPIGF PTRAHPTLQA PSLEDVTKQY MLNLHSGEVP 

      1030       1040       1050       1060       1070       1080 
APVPVDMPCL PLAAPPSAEA KPPEAARPAD EPTPASKCCS KPQVDMRKHV AMTLLDTEQS 

      1090       1100       1110       1120       1130       1140 
YVESLRTLMQ GYMQPLKQPE NSVLCDPSLV DEIFDQIPEL LEHHEQFLEQ VRHCMQTWHA 

      1150       1160       1170       1180       1190       1200 
QQKVGALLVQ SFSKDVLVNI YSAYIDNFLN AKDAVRVAKE ARPAFLKFLE QSMRENKEKQ 

      1210       1220       1230       1240       1250       1260 
ALSDLMIKPV QRIPRYELLV KDLLKHTPED HPDHPLLLEA QRNIKQVAER INKGVRSAEE 

      1270       1280       1290       1300       1310       1320 
AERHARVLQE IEAHIEGMED LQAPLRRFLR QEMVIEVKAI GGKKDRSLFL FTDLIVCTTL 

      1330       1340       1350       1360       1370       1380 
KRKSGSLRRS SMSLYTAASV IDTASKYKML WKLPLEDADI IKGASQATNR ENIQKAISRL 

      1390       1400       1410       1420       1430       1440 
DEDLTTLGQM SKLSESLGFP HQSLDDALRD LSAAMHRDLS EKQALCYALS FPPTKLELCA 

      1450       1460       1470       1480       1490       1500 
TRPEGTDSYI FEFPHPDARL GFEQAFDEAK RKLASSKSCL DPEFLKAIPI MKTRSGMQFS 

      1510       1520       1530       1540       1550       1560 
CAAPTLNSCP EPSPEVWVCN SDGYVGQVCL LSLRAEPDVE ACIAVCSARI LCIGAVPGLQ 

      1570       1580       1590       1600       1610       1620 
PRCHREPPPS LRSPPETAPE PAGPELDVEA AADEEAATLA EPGPQPCLHI SIAGSGLEMT 

      1630       1640       1650       1660       1670       1680 
PGLGEGDPRP ELVPFDSDSD DESSPSPSGT LQSQASRSTI SSSFGNEETP SSKEATAETT 

      1690       1700       1710       1720       1730       1740 
SSEEEQEPGF LPLSGSFGPG GPCGTSPMDG RALRRSSHGS FTRGSLEDLL SVDPEAYQSS 

      1750       1760       1770       1780       1790       1800 
VWLGTEDGCV HVYQSSDSIR DRRNSMKLQH AASVTCILYL NNQVFVSLAN GELVVYQREA 

      1810       1820       1830       1840       1850       1860 
GHFWDPQNFK SVTLGTQGSP ITKMVSVGGR LWCGCQNRVL VLSPDTLQLE HMFYVGQDSS 

      1870       1880       1890       1900       1910       1920 
RCVACMVDSS LGVWVTLKGS AHVCLYHPDT FEQLAEVDVT PPVHRMLAGS DAIIRQHKAA 

      1930       1940       1950       1960       1970       1980 
CLRITALLVC EELLWVGTSA GVVLTMPTSP GTVSCPRAPL SPTGLGQGHT GHVRFLAAVQ 

      1990       2000       2010       2020       2030       2040 
LPDGFNLLCP TPPPPPDTGP EKLPSLEHRD SPWHRGPAPA RPKMLVISGG DGYEDFRLSS 

      2050       2060 
GGGSSSETVG RDDSTNHLLL WRV 

« Hide

References

« Hide 'large scale' references
[1]"Cell surface tumor endothelial markers are conserved in mice and humans."
Carson-Walter E.B., Watkins D.N., Nanda A., Vogelstein B., Kinzler K.W., St Croix B.
Cancer Res. 61:6649-6655(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain and Colon.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-401.
Tissue: Embryo.
[5]"Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 455-2063.
Tissue: Brain.
[6]"A mammalian Rho-specific guanine-nucleotide exchange factor (p164-RhoGEF) without a pleckstrin homology domain."
Ruemenapp U., Freichel-Blomquist A., Wittinghofer B., Jakobs K.H., Wieland T.
Biochem. J. 366:721-728(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY.
[7]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[8]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-461, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF378754 mRNA. Translation: AAL11991.1.
CH471076 Genomic DNA. Translation: EAW74891.1.
BC050031 mRNA. Translation: AAH50031.1.
BC137228 mRNA. Translation: AAI37229.1.
AK074500 mRNA. No translation available.
AB002335 mRNA. Translation: BAA20795.2.
CCDSCCDS8221.1.
RefSeqNP_055601.2. NM_014786.3.
UniGeneHs.533719.
Hs.573929.

3D structure databases

ProteinModelPortalQ96PE2.
SMRQ96PE2. Positions 1067-1385.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115166. 2 interactions.
IntActQ96PE2. 2 interactions.
MINTMINT-3974886.
STRING9606.ENSP00000263674.

PTM databases

PhosphoSiteQ96PE2.

Polymorphism databases

DMDM74724250.

Proteomic databases

MaxQBQ96PE2.
PaxDbQ96PE2.
PRIDEQ96PE2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000263674; ENSP00000263674; ENSG00000110237.
GeneID9828.
KEGGhsa:9828.
UCSCuc001otu.3. human.

Organism-specific databases

CTD9828.
GeneCardsGC11P073019.
H-InvDBHIX0171270.
HGNCHGNC:21726. ARHGEF17.
HPAHPA007991.
neXtProtNX_Q96PE2.
PharmGKBPA134884537.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG312337.
HOGENOMHOG000034048.
HOVERGENHBG095607.
InParanoidQ96PE2.
OMAMGAQQDD.
OrthoDBEOG7P2XR5.
PhylomeDBQ96PE2.
TreeFamTF324157.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeQ96PE2.
CleanExHS_ARHGEF17.
GenevestigatorQ96PE2.

Family and domain databases

Gene3D1.20.900.10. 1 hit.
2.130.10.10. 1 hit.
2.30.29.30. 1 hit.
InterProIPR000219. DH-domain.
IPR011993. PH_like_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamPF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTSM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMSSF48065. SSF48065. 1 hit.
SSF50978. SSF50978. 1 hit.
PROSITEPS50010. DH_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi9828.
NextBio37026.
PROQ96PE2.

Entry information

Entry nameARHGH_HUMAN
AccessionPrimary (citable) accession number: Q96PE2
Secondary accession number(s): B2RP20 expand/collapse secondary AC list , Q86XU2, Q8N2S0, Q9Y4G3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM