Q96PE1 (GP124_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
G-protein coupled receptor 124

Alternative name(s):
Tumor endothelial marker 5

Gene names

Name:	GPR124
Synonyms:	KIAA1531, TEM5

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1338 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Endothelial receptor that acts as an essential regulator of CNS angiogenesis. Required for normal endothelial cell sprouting and migration in the forebrain and neural tube By similarity.
Subunit structure	Interacts with DLG1. Ref.11
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Expressed in endothelial cells (at protein level). Abundantly expressed in tumor vessels, heart, placenta, ovary, small intestine, and colon. Ref.11
Domain	Binds to DLG1 through its PDZ-binding motif.
Sequence similarities	Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. Contains 1 GPS domain. Contains 1 Ig-like (immunoglobulin-like) domain. Contains 4 LRR (leucine-rich) repeats. Contains 1 LRRCT domain. Contains 1 LRRNT domain.
Caution	It is uncertain whether Met-1 or Met-8 is the initiator.
Sequence caution	The sequence AAI46775.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence AAL11992.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence AAO27354.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAA96055.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Biological process	Angiogenesis
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing
Domain	Immunoglobulin domain Leucine-rich repeat Repeat Signal Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	central nervous system development Inferred from sequence or structural similarity. Source: UniProtKB endothelial cell migration Inferred from sequence or structural similarity. Source: UniProtKB neuropeptide signaling pathway Inferred from electronic annotation. Source: InterPro regulation of angiogenesis Inferred from sequence or structural similarity. Source: UniProtKB regulation of chemotaxis Inferred from sequence or structural similarity. Source: UniProtKB sprouting angiogenesis Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	integral to membrane Traceable author statement PubMed 15203201. Source: GDB plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	G-protein coupled receptor activity Traceable author statement PubMed 15203201. Source: GDB
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96PE1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96PE1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     537-753: Missing.

Isoform 3 (identifier: Q96PE1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     186-1338: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 33	33	Potential
	Chain	34 – 1338	1305	G-protein coupled receptor 124		PRO_0000012898
Regions
	Topological domain	34 – 771	738	Extracellular Potential
	Transmembrane	772 – 792	21	Helical; Name=1; Potential
	Topological domain	793 – 807	15	Cytoplasmic Potential
	Transmembrane	808 – 828	21	Helical; Name=2; Potential
	Topological domain	829 – 832	4	Extracellular Potential
	Transmembrane	833 – 853	21	Helical; Name=3; Potential
	Topological domain	854 – 886	33	Cytoplasmic Potential
	Transmembrane	887 – 907	21	Helical; Name=4; Potential
	Topological domain	908 – 924	17	Extracellular Potential
	Transmembrane	925 – 945	21	Helical; Name=5; Potential
	Topological domain	946 – 1019	74	Cytoplasmic Potential
	Transmembrane	1020 – 1040	21	Helical; Name=6; Potential
	Topological domain	1041 – 1047	7	Extracellular Potential
	Transmembrane	1048 – 1068	21	Helical; Name=7; Potential
	Topological domain	1069 – 1338	270	Cytoplasmic Potential
	Domain	34 – 84	51	LRRNT
	Repeat	85 – 106	22	LRR 1
	Repeat	109 – 130	22	LRR 2
	Repeat	133 – 154	22	LRR 3
	Repeat	157 – 178	22	LRR 4
	Domain	190 – 241	52	LRRCT
	Domain	247 – 344	98	Ig-like
	Domain	707 – 758	52	GPS
	Motif	1335 – 1338	4	PDZ-binding
Amino acid modifications
	Glycosylation	84	1	N-linked (GlcNAc...) Potential
	Glycosylation	101	1	N-linked (GlcNAc...) Potential
	Glycosylation	162	1	N-linked (GlcNAc...) Potential
	Glycosylation	207	1	N-linked (GlcNAc...) Potential
	Glycosylation	275	1	N-linked (GlcNAc...) Potential
	Glycosylation	336	1	N-linked (GlcNAc...) Potential
	Glycosylation	436	1	N-linked (GlcNAc...) Potential
	Glycosylation	602	1	N-linked (GlcNAc...) Potential
	Glycosylation	659	1	N-linked (GlcNAc...) Potential
	Glycosylation	690	1	N-linked (GlcNAc...) Potential
	Glycosylation	737	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	186 – 1338	1153	Missing in isoform 3.		VSP_036215
	Alternative sequence	537 – 753	217	Missing in isoform 2.		VSP_010076
Experimental info
	Sequence conflict	94	1	N → K in BAB84925. Ref.9
	Sequence conflict	407	1	G → S in BAB84925. Ref.9
	Sequence conflict	1221	1	S → G in BAA96055. Ref.2
	Sequence conflict	1221	1	S → G in AAI46775. Ref.7

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 20, 2009. Version 2. Checksum: 322838CB31E99A97	FASTA	1,338	142,647
	10 20 30 40 50 60 MGAGGRRMRG APARLLLPLL PWLLLLLAPE ARGAPGCPLS IRSCKCSGER PKGLSGGVPG 70 80 90 100 110 120 PARRRVVCSG GDLPEPPEPG LLPNGTVTLL LSNNKITGLR NGSFLGLSLL EKLDLRNNII 130 140 150 160 170 180 STVQPGAFLG LGELKRLDLS NNRIGCLTSE TFQGLPRLLR LNISGNIFSS LQPGVFDELP 190 200 210 220 230 240 ALKVVDLGTE FLTCDCHLRW LLPWAQNRSL QLSEHTLCAY PSALHAQALG SLQEAQLCCE 250 260 270 280 290 300 GALELHTHHL IPSLRQVVFQ GDRLPFQCSA SYLGNDTRIR WYHNRAPVEG DEQAGILLAE 310 320 330 340 350 360 SLIHDCTFIT SELTLSHIGV WASGEWECTV SMAQGNASKK VEIVVLETSA SYCPAERVAN 370 380 390 400 410 420 NRGDFRWPRT LAGITAYQSC LQYPFTSVPL GGGAPGTRAS RRCDRAGRWE PGDYSHCLYT 430 440 450 460 470 480 NDITRVLYTF VLMPINASNA LTLAHQLRVY TAEAASFSDM MDVVYVAQMI QKFLGYVDQI 490 500 510 520 530 540 KELVEVMVDM ASNLMLVDEH LLWLAQREDK ACSRIVGALE RIGGAALSPH AQHISVNARN 550 560 570 580 590 600 VALEAYLIKP HSYVGLTCTA FQRREGGVPG TRPGSPGQNP PPEPEPPADQ QLRFRCTTGR 610 620 630 640 650 660 PNVSLSSFHI KNSVALASIQ LPPSLFSSLP AALAPPVPPD CTLQLLVFRN GRLFHSHSNT 670 680 690 700 710 720 SRPGAAGPGK RRGVATPVIF AGTSGCGVGN LTEPVAVSLR HWAEGAEPVA AWWSQEGPGE 730 740 750 760 770 780 AGGWTSEGCQ LRSSQPNVSA LHCQHLGNVA VLMELSAFPR EVGGAGAGLH PVVYPCTALL 790 800 810 820 830 840 LLCLFATIIT YILNHSSIRV SRKGWHMLLN LCFHIAMTSA VFAGGITLTN YQMVCQAVGI 850 860 870 880 890 900 TLHYSSLSTL LWMGVKARVL HKELTWRAPP PQEGDPALPT PSPMLRFYLI AGGIPLIICG 910 920 930 940 950 960 ITAAVNIHNY RDHSPYCWLV WRPSLGAFYI PVALILLITW IYFLCAGLRL RGPLAQNPKA 970 980 990 1000 1010 1020 GNSRASLEAG EELRGSTRLR GSGPLLSDSG SLLATGSARV GTPGPPEDGD SLYSPGVQLG 1030 1040 1050 1060 1070 1080 ALVTTHFLYL AMWACGALAV SQRWLPRVVC SCLYGVAASA LGLFVFTHHC ARRRDVRASW 1090 1100 1110 1120 1130 1140 RACCPPASPA APHAPPRALP AAAEDGSPVF GEGPPSLKSS PSGSSGHPLA LGPCKLTNLQ 1150 1160 1170 1180 1190 1200 LAQSQVCEAG AAAGGEGEPE PAGTRGNLAH RHPNNVHHGR RAHKSRAKGH RAGEACGKNR 1210 1220 1230 1240 1250 1260 LKALRGGAAG ALELLSSESG SLHNSPTDSY LGSSRNSPGA GLQLEGEPML TPSEGSDTSA 1270 1280 1290 1300 1310 1320 APLSEAGRAG QRRSASRDSL KGGGALEKES HRRSYPLNAA SLNGAPKGGK YDDVTLMGAE 1330 VASGGCMKTG LWKSETTV
	Isoform 2 [UniParc]. Checksum: 5A118A1292E3DCEE	FASTA	1,121	119,862
	10 20 30 40 50 60 MGAGGRRMRG APARLLLPLL PWLLLLLAPE ARGAPGCPLS IRSCKCSGER PKGLSGGVPG 70 80 90 100 110 120 PARRRVVCSG GDLPEPPEPG LLPNGTVTLL LSNNKITGLR NGSFLGLSLL EKLDLRNNII 130 140 150 160 170 180 STVQPGAFLG LGELKRLDLS NNRIGCLTSE TFQGLPRLLR LNISGNIFSS LQPGVFDELP 190 200 210 220 230 240 ALKVVDLGTE FLTCDCHLRW LLPWAQNRSL QLSEHTLCAY PSALHAQALG SLQEAQLCCE 250 260 270 280 290 300 GALELHTHHL IPSLRQVVFQ GDRLPFQCSA SYLGNDTRIR WYHNRAPVEG DEQAGILLAE 310 320 330 340 350 360 SLIHDCTFIT SELTLSHIGV WASGEWECTV SMAQGNASKK VEIVVLETSA SYCPAERVAN 370 380 390 400 410 420 NRGDFRWPRT LAGITAYQSC LQYPFTSVPL GGGAPGTRAS RRCDRAGRWE PGDYSHCLYT 430 440 450 460 470 480 NDITRVLYTF VLMPINASNA LTLAHQLRVY TAEAASFSDM MDVVYVAQMI QKFLGYVDQI 490 500 510 520 530 540 KELVEVMVDM ASNLMLVDEH LLWLAQREDK ACSRIVGALE RIGGAALSPH AQHISVELSA 550 560 570 580 590 600 FPREVGGAGA GLHPVVYPCT ALLLLCLFAT IITYILNHSS IRVSRKGWHM LLNLCFHIAM 610 620 630 640 650 660 TSAVFAGGIT LTNYQMVCQA VGITLHYSSL STLLWMGVKA RVLHKELTWR APPPQEGDPA 670 680 690 700 710 720 LPTPSPMLRF YLIAGGIPLI ICGITAAVNI HNYRDHSPYC WLVWRPSLGA FYIPVALILL 730 740 750 760 770 780 ITWIYFLCAG LRLRGPLAQN PKAGNSRASL EAGEELRGST RLRGSGPLLS DSGSLLATGS 790 800 810 820 830 840 ARVGTPGPPE DGDSLYSPGV QLGALVTTHF LYLAMWACGA LAVSQRWLPR VVCSCLYGVA 850 860 870 880 890 900 ASALGLFVFT HHCARRRDVR ASWRACCPPA SPAAPHAPPR ALPAAAEDGS PVFGEGPPSL 910 920 930 940 950 960 KSSPSGSSGH PLALGPCKLT NLQLAQSQVC EAGAAAGGEG EPEPAGTRGN LAHRHPNNVH 970 980 990 1000 1010 1020 HGRRAHKSRA KGHRAGEACG KNRLKALRGG AAGALELLSS ESGSLHNSPT DSYLGSSRNS 1030 1040 1050 1060 1070 1080 PGAGLQLEGE PMLTPSEGSD TSAAPLSEAG RAGQRRSASR DSLKGGGALE KESHRRSYPL 1090 1100 1110 1120 NAASLNGAPK GGKYDDVTLM GAEVASGGCM KTGLWKSETT V
	Isoform 3 [UniParc]. Checksum: 28984931C571C168	FASTA	185	19,530
	10 20 30 40 50 60 MGAGGRRMRG APARLLLPLL PWLLLLLAPE ARGAPGCPLS IRSCKCSGER PKGLSGGVPG 70 80 90 100 110 120 PARRRVVCSG GDLPEPPEPG LLPNGTVTLL LSNNKITGLR NGSFLGLSLL EKLDLRNNII 130 140 150 160 170 180 STVQPGAFLG LGELKRLDLS NNRIGCLTSE TFQGLPRLLR LNISGNIFSS LQPGVFDELP ALKVV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cell surface tumor endothelial markers are conserved in mice and humans." Carson-Walter E.B., Watkins D.N., Nanda A., Vogelstein B., Kinzler K.W., St Croix B. Cancer Res. 61:6649-6655(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O. DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[3]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Embryo.
[5]	"DNA sequence and analysis of human chromosome 8." Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S. Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[8]	"There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini." Fredriksson R., Gloriam D.E.I., Hoeglund P.J., Lagerstroem M.C., Schioeth H.B. Biochem. Biophys. Res. Commun. 301:725-734(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 8-1338 (ISOFORM 1).
[9]	"The nucleotide sequence of a long cDNA clone isolated from human spleen." Jikuya H., Takano J., Nomura N., Kikuno R., Nagase T., Ohara O. Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 29-1338 (ISOFORM 1). Tissue: Spleen.
[10]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 850-1338. Tissue: Amygdala and Testis.
[11]	"Direct binding of the human homologue of the Drosophila disc large tumor suppressor gene to seven-pass transmembrane proteins, tumor endothelial marker 5 (TEM5), and a novel TEM5-like protein." Yamamoto Y., Irie K., Asada M., Mino A., Mandai K., Takai Y. Oncogene 23:3889-3897(2004) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, INTERACTION WITH DLG1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF378755 mRNA. Translation: AAL11992.1. Different initiation. AB040964 mRNA. Translation: BAA96055.2. Different initiation. AK027296 mRNA. Translation: BAB55022.1. AC138356 Genomic DNA. No translation available. CH471080 Genomic DNA. Translation: EAW63355.1. CH471080 Genomic DNA. Translation: EAW63356.1. BC146774 mRNA. Translation: AAI46775.1. Different initiation. AY181242 mRNA. Translation: AAO27354.1. Different initiation. AK074099 mRNA. Translation: BAB84925.1. AL110244 mRNA. Translation: CAB53694.1. AL832524 mRNA. Translation: CAD38629.1.
IPI	IPI00292834. IPI00743456. IPI00971009.
PIR	T14774.
RefSeq	NP_116166.9. NM_032777.9.
UniGene	Hs.274136.
3D structure databases
ProteinModelPortal	Q96PE1.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000406367.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q96PE1.
Polymorphism databases
DMDM	221222450.
Proteomic databases
PaxDb	Q96PE1.
PRIDE	Q96PE1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000315215; ENSP00000323508; ENSG00000020181. ENST00000412232; ENSP00000406367; ENSG00000020181.
GeneID	25960.
KEGG	hsa:25960.
UCSC	uc003xki.3. human. uc003xkj.3. human. uc010lvy.3. human.
Organism-specific databases
CTD	25960.
GeneCards	GC08P037641.
HGNC	HGNC:17849. GPR124.
HPA	HPA012393.
MIM	606823. gene.
neXtProt	NX_Q96PE1.
PharmGKB	PA134869404.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG307919.
HOVERGEN	HBG051777.
InParanoid	Q96PE1.
KO	K08461.
OMA	RTLCAYP.
Enzyme and pathway databases
Pathway_Interaction_DB	avb3_integrin_pathway. Integrins in angiogenesis.
Gene expression databases
ArrayExpress	Q96PE1.
Bgee	Q96PE1.
CleanEx	HS_GPR124.
Genevestigator	Q96PE1.
GermOnline	ENSG00000020181. Homo sapiens.
Family and domain databases
Gene3D	2.60.40.10. 1 hit.
InterPro	IPR000483. Cys-rich_flank_reg_C. IPR017981. GPCR_2-like. IPR001879. GPCR_2_extracellular_dom. IPR000832. GPCR_2_secretin-like. IPR017983. GPCR_2_secretin-like_CS. IPR000203. GPS_dom. IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR003599. Ig_sub. IPR001611. Leu-rich_rpt. IPR003591. Leu-rich_rpt_typical-subtyp. [Graphical view]
Pfam	PF00002. 7tm_2. 1 hit. PF01825. GPS. 1 hit. PF02793. HRM. 1 hit. [Graphical view]
SMART	SM00303. GPS. 1 hit. SM00409. IG. 1 hit. SM00369. LRR_TYP. 1 hit. SM00082. LRRCT. 1 hit. [Graphical view]
PROSITE	PS00649. G_PROTEIN_RECEP_F2_1. False negative. PS00650. G_PROTEIN_RECEP_F2_2. 1 hit. PS50227. G_PROTEIN_RECEP_F2_3. 1 hit. PS50261. G_PROTEIN_RECEP_F2_4. 1 hit. PS50221. GPS. 1 hit. PS50835. IG_LIKE. 1 hit. PS51450. LRR. 4 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	25960.
NextBio	47578.
SOURCE	Search...

Entry information

Entry name

GP124_HUMAN

Accession

Primary (citable) accession number: Q96PE1
Secondary accession number(s): A6H8W3 , D3DSW4, Q8N3R1, Q8TEM3, Q96KB2, Q9P1Z7, Q9UFY4

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 13, 2004
Last sequence update:	January 20, 2009
Last modified:	May 1, 2013
This is version 114 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.