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Q96PE1

- GP124_HUMAN

UniProt

Q96PE1 - GP124_HUMAN

Protein

G-protein coupled receptor 124

Gene

GPR124

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 2 (20 Jan 2009)
      Previous versions | rss
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    Functioni

    Endothelial receptor that acts as an essential regulator of CNS angiogenesis. Required for normal endothelial cell sprouting and migration in the forebrain and neural tube By similarity.By similarity

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: GDB

    GO - Biological processi

    1. central nervous system development Source: UniProtKB
    2. endothelial cell migration Source: UniProtKB
    3. G-protein coupled receptor signaling pathway Source: GDB
    4. negative regulation of vascular endothelial growth factor signaling pathway Source: Ensembl
    5. neuropeptide signaling pathway Source: InterPro
    6. positive regulation of endothelial cell migration Source: Ensembl
    7. regulation of angiogenesis Source: UniProtKB
    8. regulation of chemotaxis Source: UniProtKB
    9. regulation of establishment of blood-brain barrier Source: Ensembl
    10. sprouting angiogenesis Source: UniProtKB

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Angiogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    G-protein coupled receptor 124
    Alternative name(s):
    Tumor endothelial marker 5
    Gene namesi
    Name:GPR124
    Synonyms:KIAA1531, TEM5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:17849. GPR124.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: Ensembl
    2. integral component of membrane Source: GDB
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134869404.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3333Sequence AnalysisAdd
    BLAST
    Chaini34 – 13381305G-protein coupled receptor 124PRO_0000012898Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi84 – 841N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi101 – 1011N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi162 – 1621N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi207 – 2071N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi275 – 2751N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi336 – 3361N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi436 – 4361N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi602 – 6021N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi659 – 6591N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi690 – 6901N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi737 – 7371N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ96PE1.
    PRIDEiQ96PE1.

    PTM databases

    PhosphoSiteiQ96PE1.

    Expressioni

    Tissue specificityi

    Expressed in endothelial cells (at protein level). Abundantly expressed in tumor vessels, heart, placenta, ovary, small intestine, and colon.1 Publication

    Gene expression databases

    ArrayExpressiQ96PE1.
    BgeeiQ96PE1.
    CleanExiHS_GPR124.
    GenevestigatoriQ96PE1.

    Organism-specific databases

    HPAiHPA012393.

    Interactioni

    Subunit structurei

    Interacts with DLG1.1 Publication

    Protein-protein interaction databases

    BioGridi117450. 2 interactions.
    STRINGi9606.ENSP00000406367.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96PE1.
    SMRiQ96PE1. Positions 37-338.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini34 – 771738ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini793 – 80715CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini829 – 8324ExtracellularSequence Analysis
    Topological domaini854 – 88633CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini908 – 92417ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini946 – 101974CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini1041 – 10477ExtracellularSequence Analysis
    Topological domaini1069 – 1338270CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei772 – 79221Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei808 – 82821Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei833 – 85321Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei887 – 90721Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei925 – 94521Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei1020 – 104021Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei1048 – 106821Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini34 – 8451LRRNTAdd
    BLAST
    Repeati85 – 10622LRR 1Add
    BLAST
    Repeati109 – 13022LRR 2Add
    BLAST
    Repeati133 – 15422LRR 3Add
    BLAST
    Repeati157 – 17822LRR 4Add
    BLAST
    Domaini190 – 24152LRRCTAdd
    BLAST
    Domaini247 – 34498Ig-likeAdd
    BLAST
    Domaini707 – 75852GPSPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi1335 – 13384PDZ-binding

    Domaini

    Binds to DLG1 through its PDZ-binding motif.

    Sequence similaritiesi

    Contains 1 GPS domain.PROSITE-ProRule annotation
    Contains 4 LRR (leucine-rich) repeats.Curated
    Contains 1 LRRCT domain.Curated
    Contains 1 LRRNT domain.Curated

    Keywords - Domaini

    Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG307919.
    HOVERGENiHBG051777.
    InParanoidiQ96PE1.
    KOiK08461.
    OMAiRTLCAYP.
    OrthoDBiEOG7RV9F8.
    PhylomeDBiQ96PE1.
    TreeFamiTF331206.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR000483. Cys-rich_flank_reg_C.
    IPR017981. GPCR_2-like.
    IPR001879. GPCR_2_extracellular_dom.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    IPR000203. GPS.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR001611. Leu-rich_rpt.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    [Graphical view]
    PfamiPF00002. 7tm_2. 1 hit.
    PF01825. GPS. 1 hit.
    PF02793. HRM. 1 hit.
    PF13855. LRR_8. 1 hit.
    [Graphical view]
    SMARTiSM00303. GPS. 1 hit.
    SM00409. IG. 1 hit.
    SM00369. LRR_TYP. 1 hit.
    SM00082. LRRCT. 1 hit.
    [Graphical view]
    PROSITEiPS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    PS50221. GPS. 1 hit.
    PS50835. IG_LIKE. 1 hit.
    PS51450. LRR. 4 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96PE1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGAGGRRMRG APARLLLPLL PWLLLLLAPE ARGAPGCPLS IRSCKCSGER     50
    PKGLSGGVPG PARRRVVCSG GDLPEPPEPG LLPNGTVTLL LSNNKITGLR 100
    NGSFLGLSLL EKLDLRNNII STVQPGAFLG LGELKRLDLS NNRIGCLTSE 150
    TFQGLPRLLR LNISGNIFSS LQPGVFDELP ALKVVDLGTE FLTCDCHLRW 200
    LLPWAQNRSL QLSEHTLCAY PSALHAQALG SLQEAQLCCE GALELHTHHL 250
    IPSLRQVVFQ GDRLPFQCSA SYLGNDTRIR WYHNRAPVEG DEQAGILLAE 300
    SLIHDCTFIT SELTLSHIGV WASGEWECTV SMAQGNASKK VEIVVLETSA 350
    SYCPAERVAN NRGDFRWPRT LAGITAYQSC LQYPFTSVPL GGGAPGTRAS 400
    RRCDRAGRWE PGDYSHCLYT NDITRVLYTF VLMPINASNA LTLAHQLRVY 450
    TAEAASFSDM MDVVYVAQMI QKFLGYVDQI KELVEVMVDM ASNLMLVDEH 500
    LLWLAQREDK ACSRIVGALE RIGGAALSPH AQHISVNARN VALEAYLIKP 550
    HSYVGLTCTA FQRREGGVPG TRPGSPGQNP PPEPEPPADQ QLRFRCTTGR 600
    PNVSLSSFHI KNSVALASIQ LPPSLFSSLP AALAPPVPPD CTLQLLVFRN 650
    GRLFHSHSNT SRPGAAGPGK RRGVATPVIF AGTSGCGVGN LTEPVAVSLR 700
    HWAEGAEPVA AWWSQEGPGE AGGWTSEGCQ LRSSQPNVSA LHCQHLGNVA 750
    VLMELSAFPR EVGGAGAGLH PVVYPCTALL LLCLFATIIT YILNHSSIRV 800
    SRKGWHMLLN LCFHIAMTSA VFAGGITLTN YQMVCQAVGI TLHYSSLSTL 850
    LWMGVKARVL HKELTWRAPP PQEGDPALPT PSPMLRFYLI AGGIPLIICG 900
    ITAAVNIHNY RDHSPYCWLV WRPSLGAFYI PVALILLITW IYFLCAGLRL 950
    RGPLAQNPKA GNSRASLEAG EELRGSTRLR GSGPLLSDSG SLLATGSARV 1000
    GTPGPPEDGD SLYSPGVQLG ALVTTHFLYL AMWACGALAV SQRWLPRVVC 1050
    SCLYGVAASA LGLFVFTHHC ARRRDVRASW RACCPPASPA APHAPPRALP 1100
    AAAEDGSPVF GEGPPSLKSS PSGSSGHPLA LGPCKLTNLQ LAQSQVCEAG 1150
    AAAGGEGEPE PAGTRGNLAH RHPNNVHHGR RAHKSRAKGH RAGEACGKNR 1200
    LKALRGGAAG ALELLSSESG SLHNSPTDSY LGSSRNSPGA GLQLEGEPML 1250
    TPSEGSDTSA APLSEAGRAG QRRSASRDSL KGGGALEKES HRRSYPLNAA 1300
    SLNGAPKGGK YDDVTLMGAE VASGGCMKTG LWKSETTV 1338
    Length:1,338
    Mass (Da):142,647
    Last modified:January 20, 2009 - v2
    Checksum:i322838CB31E99A97
    GO
    Isoform 2 (identifier: Q96PE1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         537-753: Missing.

    Show »
    Length:1,121
    Mass (Da):119,862
    Checksum:i5A118A1292E3DCEE
    GO
    Isoform 3 (identifier: Q96PE1-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         186-1338: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:185
    Mass (Da):19,530
    Checksum:i28984931C571C168
    GO

    Sequence cautioni

    The sequence AAI46775.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAL11992.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAO27354.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAA96055.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti407 – 4071G → S in BAB84925. 1 PublicationCurated
    Sequence conflicti1221 – 12211S → G in BAA96055. (PubMed:10819331)Curated
    Sequence conflicti1221 – 12211S → G in AAI46775. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei186 – 13381153Missing in isoform 3. 1 PublicationVSP_036215Add
    BLAST
    Alternative sequencei537 – 753217Missing in isoform 2. 2 PublicationsVSP_010076Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF378755 mRNA. Translation: AAL11992.1. Different initiation.
    AB040964 mRNA. Translation: BAA96055.2. Different initiation.
    AK027296 mRNA. Translation: BAB55022.1.
    AC138356 Genomic DNA. No translation available.
    CH471080 Genomic DNA. Translation: EAW63355.1.
    CH471080 Genomic DNA. Translation: EAW63356.1.
    BC146774 mRNA. Translation: AAI46775.1. Different initiation.
    AY181242 mRNA. Translation: AAO27354.1. Different initiation.
    AK074099 mRNA. Translation: BAB84925.2.
    AL110244 mRNA. Translation: CAB53694.1.
    AL832524 mRNA. Translation: CAD38629.1.
    CCDSiCCDS6097.2. [Q96PE1-1]
    PIRiT14774.
    RefSeqiNP_116166.9. NM_032777.9. [Q96PE1-1]
    UniGeneiHs.274136.

    Genome annotation databases

    EnsembliENST00000315215; ENSP00000323508; ENSG00000020181. [Q96PE1-2]
    ENST00000412232; ENSP00000406367; ENSG00000020181. [Q96PE1-1]
    GeneIDi25960.
    KEGGihsa:25960.
    UCSCiuc003xki.3. human. [Q96PE1-3]
    uc003xkj.3. human. [Q96PE1-1]
    uc010lvy.3. human. [Q96PE1-2]

    Polymorphism databases

    DMDMi221222450.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF378755 mRNA. Translation: AAL11992.1 . Different initiation.
    AB040964 mRNA. Translation: BAA96055.2 . Different initiation.
    AK027296 mRNA. Translation: BAB55022.1 .
    AC138356 Genomic DNA. No translation available.
    CH471080 Genomic DNA. Translation: EAW63355.1 .
    CH471080 Genomic DNA. Translation: EAW63356.1 .
    BC146774 mRNA. Translation: AAI46775.1 . Different initiation.
    AY181242 mRNA. Translation: AAO27354.1 . Different initiation.
    AK074099 mRNA. Translation: BAB84925.2 .
    AL110244 mRNA. Translation: CAB53694.1 .
    AL832524 mRNA. Translation: CAD38629.1 .
    CCDSi CCDS6097.2. [Q96PE1-1 ]
    PIRi T14774.
    RefSeqi NP_116166.9. NM_032777.9. [Q96PE1-1 ]
    UniGenei Hs.274136.

    3D structure databases

    ProteinModelPortali Q96PE1.
    SMRi Q96PE1. Positions 37-338.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117450. 2 interactions.
    STRINGi 9606.ENSP00000406367.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q96PE1.

    Polymorphism databases

    DMDMi 221222450.

    Proteomic databases

    PaxDbi Q96PE1.
    PRIDEi Q96PE1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000315215 ; ENSP00000323508 ; ENSG00000020181 . [Q96PE1-2 ]
    ENST00000412232 ; ENSP00000406367 ; ENSG00000020181 . [Q96PE1-1 ]
    GeneIDi 25960.
    KEGGi hsa:25960.
    UCSCi uc003xki.3. human. [Q96PE1-3 ]
    uc003xkj.3. human. [Q96PE1-1 ]
    uc010lvy.3. human. [Q96PE1-2 ]

    Organism-specific databases

    CTDi 25960.
    GeneCardsi GC08P037641.
    HGNCi HGNC:17849. GPR124.
    HPAi HPA012393.
    MIMi 606823. gene.
    neXtProti NX_Q96PE1.
    PharmGKBi PA134869404.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG307919.
    HOVERGENi HBG051777.
    InParanoidi Q96PE1.
    KOi K08461.
    OMAi RTLCAYP.
    OrthoDBi EOG7RV9F8.
    PhylomeDBi Q96PE1.
    TreeFami TF331206.

    Miscellaneous databases

    GeneWikii GPR124.
    GenomeRNAii 25960.
    NextBioi 47578.
    PROi Q96PE1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96PE1.
    Bgeei Q96PE1.
    CleanExi HS_GPR124.
    Genevestigatori Q96PE1.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR000483. Cys-rich_flank_reg_C.
    IPR017981. GPCR_2-like.
    IPR001879. GPCR_2_extracellular_dom.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    IPR000203. GPS.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR001611. Leu-rich_rpt.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    [Graphical view ]
    Pfami PF00002. 7tm_2. 1 hit.
    PF01825. GPS. 1 hit.
    PF02793. HRM. 1 hit.
    PF13855. LRR_8. 1 hit.
    [Graphical view ]
    SMARTi SM00303. GPS. 1 hit.
    SM00409. IG. 1 hit.
    SM00369. LRR_TYP. 1 hit.
    SM00082. LRRCT. 1 hit.
    [Graphical view ]
    PROSITEi PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    PS50221. GPS. 1 hit.
    PS50835. IG_LIKE. 1 hit.
    PS51450. LRR. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cell surface tumor endothelial markers are conserved in mice and humans."
      Carson-Walter E.B., Watkins D.N., Nanda A., Vogelstein B., Kinzler K.W., St Croix B.
      Cancer Res. 61:6649-6655(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
      DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
      DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Embryo.
    5. "DNA sequence and analysis of human chromosome 8."
      Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
      , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
      Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    8. "There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini."
      Fredriksson R., Gloriam D.E.I., Hoeglund P.J., Lagerstroem M.C., Schioeth H.B.
      Biochem. Biophys. Res. Commun. 301:725-734(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 8-1338 (ISOFORM 1).
    9. "The nucleotide sequence of a long cDNA clone isolated from human spleen."
      Jikuya H., Takano J., Nomura N., Kikuno R., Nagase T., Ohara O.
      Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 29-1338 (ISOFORM 1).
      Tissue: Spleen.
    10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 850-1338.
      Tissue: Amygdala and Testis.
    11. "Direct binding of the human homologue of the Drosophila disc large tumor suppressor gene to seven-pass transmembrane proteins, tumor endothelial marker 5 (TEM5), and a novel TEM5-like protein."
      Yamamoto Y., Irie K., Asada M., Mino A., Mandai K., Takai Y.
      Oncogene 23:3889-3897(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, INTERACTION WITH DLG1.

    Entry informationi

    Entry nameiGP124_HUMAN
    AccessioniPrimary (citable) accession number: Q96PE1
    Secondary accession number(s): A6H8W3
    , D3DSW4, Q8N3R1, Q8TEM3, Q96KB2, Q9P1Z7, Q9UFY4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: January 20, 2009
    Last modified: October 1, 2014
    This is version 125 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3