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Q96PE1

- GP124_HUMAN

UniProt

Q96PE1 - GP124_HUMAN

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Protein

G-protein coupled receptor 124

Gene

GPR124

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Endothelial receptor that acts as an essential regulator of CNS angiogenesis. Required for normal endothelial cell sprouting and migration in the forebrain and neural tube (By similarity).By similarity

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: GDB

GO - Biological processi

  1. central nervous system development Source: UniProtKB
  2. endothelial cell migration Source: UniProtKB
  3. G-protein coupled receptor signaling pathway Source: GDB
  4. negative regulation of vascular endothelial growth factor signaling pathway Source: Ensembl
  5. neuropeptide signaling pathway Source: InterPro
  6. positive regulation of endothelial cell migration Source: Ensembl
  7. regulation of angiogenesis Source: UniProtKB
  8. regulation of chemotaxis Source: UniProtKB
  9. regulation of establishment of blood-brain barrier Source: Ensembl
  10. sprouting angiogenesis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Angiogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 124
Alternative name(s):
Tumor endothelial marker 5
Gene namesi
Name:GPR124
Synonyms:KIAA1531, TEM5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:17849. GPR124.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini34 – 771738ExtracellularSequence AnalysisAdd
BLAST
Transmembranei772 – 79221Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini793 – 80715CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei808 – 82821Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini829 – 8324ExtracellularSequence Analysis
Transmembranei833 – 85321Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini854 – 88633CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei887 – 90721Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini908 – 92417ExtracellularSequence AnalysisAdd
BLAST
Transmembranei925 – 94521Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini946 – 101974CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei1020 – 104021Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini1041 – 10477ExtracellularSequence Analysis
Transmembranei1048 – 106821Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini1069 – 1338270CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell surface Source: Ensembl
  2. integral component of membrane Source: GDB
  3. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134869404.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333Sequence AnalysisAdd
BLAST
Chaini34 – 13381305G-protein coupled receptor 124PRO_0000012898Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi84 – 841N-linked (GlcNAc...)Sequence Analysis
Glycosylationi101 – 1011N-linked (GlcNAc...)Sequence Analysis
Glycosylationi162 – 1621N-linked (GlcNAc...)Sequence Analysis
Glycosylationi207 – 2071N-linked (GlcNAc...)Sequence Analysis
Glycosylationi275 – 2751N-linked (GlcNAc...)Sequence Analysis
Glycosylationi336 – 3361N-linked (GlcNAc...)Sequence Analysis
Glycosylationi436 – 4361N-linked (GlcNAc...)Sequence Analysis
Glycosylationi602 – 6021N-linked (GlcNAc...)Sequence Analysis
Glycosylationi659 – 6591N-linked (GlcNAc...)Sequence Analysis
Glycosylationi690 – 6901N-linked (GlcNAc...)Sequence Analysis
Glycosylationi737 – 7371N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ96PE1.
PRIDEiQ96PE1.

PTM databases

PhosphoSiteiQ96PE1.

Expressioni

Tissue specificityi

Expressed in endothelial cells (at protein level). Abundantly expressed in tumor vessels, heart, placenta, ovary, small intestine, and colon.1 Publication

Gene expression databases

BgeeiQ96PE1.
CleanExiHS_GPR124.
ExpressionAtlasiQ96PE1. baseline and differential.
GenevestigatoriQ96PE1.

Organism-specific databases

HPAiHPA012393.

Interactioni

Subunit structurei

Interacts with DLG1.1 Publication

Protein-protein interaction databases

BioGridi117450. 2 interactions.
STRINGi9606.ENSP00000406367.

Structurei

3D structure databases

ProteinModelPortaliQ96PE1.
SMRiQ96PE1. Positions 35-338.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 8451LRRNTAdd
BLAST
Repeati85 – 10622LRR 1Add
BLAST
Repeati109 – 13022LRR 2Add
BLAST
Repeati133 – 15422LRR 3Add
BLAST
Repeati157 – 17822LRR 4Add
BLAST
Domaini190 – 24152LRRCTAdd
BLAST
Domaini247 – 34498Ig-likeAdd
BLAST
Domaini707 – 75852GPSPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1335 – 13384PDZ-binding

Domaini

Binds to DLG1 through its PDZ-binding motif.

Sequence similaritiesi

Contains 1 GPS domain.PROSITE-ProRule annotation
Contains 4 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG307919.
GeneTreeiENSGT00390000016104.
HOVERGENiHBG051777.
InParanoidiQ96PE1.
KOiK08461.
OMAiRTLCAYP.
OrthoDBiEOG7RV9F8.
PhylomeDBiQ96PE1.
TreeFamiTF331206.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
PF02793. HRM. 1 hit.
PF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00303. GPS. 1 hit.
SM00409. IG. 1 hit.
SM00369. LRR_TYP. 1 hit.
SM00082. LRRCT. 1 hit.
[Graphical view]
PROSITEiPS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
PS50835. IG_LIKE. 1 hit.
PS51450. LRR. 4 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96PE1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGAGGRRMRG APARLLLPLL PWLLLLLAPE ARGAPGCPLS IRSCKCSGER
60 70 80 90 100
PKGLSGGVPG PARRRVVCSG GDLPEPPEPG LLPNGTVTLL LSNNKITGLR
110 120 130 140 150
NGSFLGLSLL EKLDLRNNII STVQPGAFLG LGELKRLDLS NNRIGCLTSE
160 170 180 190 200
TFQGLPRLLR LNISGNIFSS LQPGVFDELP ALKVVDLGTE FLTCDCHLRW
210 220 230 240 250
LLPWAQNRSL QLSEHTLCAY PSALHAQALG SLQEAQLCCE GALELHTHHL
260 270 280 290 300
IPSLRQVVFQ GDRLPFQCSA SYLGNDTRIR WYHNRAPVEG DEQAGILLAE
310 320 330 340 350
SLIHDCTFIT SELTLSHIGV WASGEWECTV SMAQGNASKK VEIVVLETSA
360 370 380 390 400
SYCPAERVAN NRGDFRWPRT LAGITAYQSC LQYPFTSVPL GGGAPGTRAS
410 420 430 440 450
RRCDRAGRWE PGDYSHCLYT NDITRVLYTF VLMPINASNA LTLAHQLRVY
460 470 480 490 500
TAEAASFSDM MDVVYVAQMI QKFLGYVDQI KELVEVMVDM ASNLMLVDEH
510 520 530 540 550
LLWLAQREDK ACSRIVGALE RIGGAALSPH AQHISVNARN VALEAYLIKP
560 570 580 590 600
HSYVGLTCTA FQRREGGVPG TRPGSPGQNP PPEPEPPADQ QLRFRCTTGR
610 620 630 640 650
PNVSLSSFHI KNSVALASIQ LPPSLFSSLP AALAPPVPPD CTLQLLVFRN
660 670 680 690 700
GRLFHSHSNT SRPGAAGPGK RRGVATPVIF AGTSGCGVGN LTEPVAVSLR
710 720 730 740 750
HWAEGAEPVA AWWSQEGPGE AGGWTSEGCQ LRSSQPNVSA LHCQHLGNVA
760 770 780 790 800
VLMELSAFPR EVGGAGAGLH PVVYPCTALL LLCLFATIIT YILNHSSIRV
810 820 830 840 850
SRKGWHMLLN LCFHIAMTSA VFAGGITLTN YQMVCQAVGI TLHYSSLSTL
860 870 880 890 900
LWMGVKARVL HKELTWRAPP PQEGDPALPT PSPMLRFYLI AGGIPLIICG
910 920 930 940 950
ITAAVNIHNY RDHSPYCWLV WRPSLGAFYI PVALILLITW IYFLCAGLRL
960 970 980 990 1000
RGPLAQNPKA GNSRASLEAG EELRGSTRLR GSGPLLSDSG SLLATGSARV
1010 1020 1030 1040 1050
GTPGPPEDGD SLYSPGVQLG ALVTTHFLYL AMWACGALAV SQRWLPRVVC
1060 1070 1080 1090 1100
SCLYGVAASA LGLFVFTHHC ARRRDVRASW RACCPPASPA APHAPPRALP
1110 1120 1130 1140 1150
AAAEDGSPVF GEGPPSLKSS PSGSSGHPLA LGPCKLTNLQ LAQSQVCEAG
1160 1170 1180 1190 1200
AAAGGEGEPE PAGTRGNLAH RHPNNVHHGR RAHKSRAKGH RAGEACGKNR
1210 1220 1230 1240 1250
LKALRGGAAG ALELLSSESG SLHNSPTDSY LGSSRNSPGA GLQLEGEPML
1260 1270 1280 1290 1300
TPSEGSDTSA APLSEAGRAG QRRSASRDSL KGGGALEKES HRRSYPLNAA
1310 1320 1330
SLNGAPKGGK YDDVTLMGAE VASGGCMKTG LWKSETTV
Length:1,338
Mass (Da):142,647
Last modified:January 20, 2009 - v2
Checksum:i322838CB31E99A97
GO
Isoform 2 (identifier: Q96PE1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     537-753: Missing.

Show »
Length:1,121
Mass (Da):119,862
Checksum:i5A118A1292E3DCEE
GO
Isoform 3 (identifier: Q96PE1-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     186-1338: Missing.

Note: No experimental confirmation available.

Show »
Length:185
Mass (Da):19,530
Checksum:i28984931C571C168
GO

Sequence cautioni

The sequence AAI46775.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAL11992.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAO27354.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA96055.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti407 – 4071G → S in BAB84925. 1 PublicationCurated
Sequence conflicti1221 – 12211S → G in BAA96055. (PubMed:10819331)Curated
Sequence conflicti1221 – 12211S → G in AAI46775. (PubMed:15489334)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei186 – 13381153Missing in isoform 3. 1 PublicationVSP_036215Add
BLAST
Alternative sequencei537 – 753217Missing in isoform 2. 2 PublicationsVSP_010076Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF378755 mRNA. Translation: AAL11992.1. Different initiation.
AB040964 mRNA. Translation: BAA96055.2. Different initiation.
AK027296 mRNA. Translation: BAB55022.1.
AC138356 Genomic DNA. No translation available.
CH471080 Genomic DNA. Translation: EAW63355.1.
CH471080 Genomic DNA. Translation: EAW63356.1.
BC146774 mRNA. Translation: AAI46775.1. Different initiation.
AY181242 mRNA. Translation: AAO27354.1. Different initiation.
AK074099 mRNA. Translation: BAB84925.2.
AL110244 mRNA. Translation: CAB53694.1.
AL832524 mRNA. Translation: CAD38629.1.
CCDSiCCDS6097.2. [Q96PE1-1]
PIRiT14774.
RefSeqiNP_116166.9. NM_032777.9. [Q96PE1-1]
UniGeneiHs.274136.

Genome annotation databases

EnsembliENST00000315215; ENSP00000323508; ENSG00000020181. [Q96PE1-2]
ENST00000412232; ENSP00000406367; ENSG00000020181. [Q96PE1-1]
GeneIDi25960.
KEGGihsa:25960.
UCSCiuc003xki.3. human. [Q96PE1-3]
uc003xkj.3. human. [Q96PE1-1]
uc010lvy.3. human. [Q96PE1-2]

Polymorphism databases

DMDMi221222450.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF378755 mRNA. Translation: AAL11992.1 . Different initiation.
AB040964 mRNA. Translation: BAA96055.2 . Different initiation.
AK027296 mRNA. Translation: BAB55022.1 .
AC138356 Genomic DNA. No translation available.
CH471080 Genomic DNA. Translation: EAW63355.1 .
CH471080 Genomic DNA. Translation: EAW63356.1 .
BC146774 mRNA. Translation: AAI46775.1 . Different initiation.
AY181242 mRNA. Translation: AAO27354.1 . Different initiation.
AK074099 mRNA. Translation: BAB84925.2 .
AL110244 mRNA. Translation: CAB53694.1 .
AL832524 mRNA. Translation: CAD38629.1 .
CCDSi CCDS6097.2. [Q96PE1-1 ]
PIRi T14774.
RefSeqi NP_116166.9. NM_032777.9. [Q96PE1-1 ]
UniGenei Hs.274136.

3D structure databases

ProteinModelPortali Q96PE1.
SMRi Q96PE1. Positions 35-338.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117450. 2 interactions.
STRINGi 9606.ENSP00000406367.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q96PE1.

Polymorphism databases

DMDMi 221222450.

Proteomic databases

PaxDbi Q96PE1.
PRIDEi Q96PE1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000315215 ; ENSP00000323508 ; ENSG00000020181 . [Q96PE1-2 ]
ENST00000412232 ; ENSP00000406367 ; ENSG00000020181 . [Q96PE1-1 ]
GeneIDi 25960.
KEGGi hsa:25960.
UCSCi uc003xki.3. human. [Q96PE1-3 ]
uc003xkj.3. human. [Q96PE1-1 ]
uc010lvy.3. human. [Q96PE1-2 ]

Organism-specific databases

CTDi 25960.
GeneCardsi GC08P037641.
HGNCi HGNC:17849. GPR124.
HPAi HPA012393.
MIMi 606823. gene.
neXtProti NX_Q96PE1.
PharmGKBi PA134869404.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG307919.
GeneTreei ENSGT00390000016104.
HOVERGENi HBG051777.
InParanoidi Q96PE1.
KOi K08461.
OMAi RTLCAYP.
OrthoDBi EOG7RV9F8.
PhylomeDBi Q96PE1.
TreeFami TF331206.

Miscellaneous databases

ChiTaRSi GPR124. human.
GeneWikii GPR124.
GenomeRNAii 25960.
NextBioi 47578.
PROi Q96PE1.
SOURCEi Search...

Gene expression databases

Bgeei Q96PE1.
CleanExi HS_GPR124.
ExpressionAtlasi Q96PE1. baseline and differential.
Genevestigatori Q96PE1.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR000483. Cys-rich_flank_reg_C.
IPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view ]
Pfami PF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
PF02793. HRM. 1 hit.
PF13855. LRR_8. 1 hit.
[Graphical view ]
SMARTi SM00303. GPS. 1 hit.
SM00409. IG. 1 hit.
SM00369. LRR_TYP. 1 hit.
SM00082. LRRCT. 1 hit.
[Graphical view ]
PROSITEi PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
PS50835. IG_LIKE. 1 hit.
PS51450. LRR. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cell surface tumor endothelial markers are conserved in mice and humans."
    Carson-Walter E.B., Watkins D.N., Nanda A., Vogelstein B., Kinzler K.W., St Croix B.
    Cancer Res. 61:6649-6655(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Embryo.
  5. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  8. "There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini."
    Fredriksson R., Gloriam D.E.I., Hoeglund P.J., Lagerstroem M.C., Schioeth H.B.
    Biochem. Biophys. Res. Commun. 301:725-734(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 8-1338 (ISOFORM 1).
  9. "The nucleotide sequence of a long cDNA clone isolated from human spleen."
    Jikuya H., Takano J., Nomura N., Kikuno R., Nagase T., Ohara O.
    Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 29-1338 (ISOFORM 1).
    Tissue: Spleen.
  10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 850-1338.
    Tissue: Amygdala and Testis.
  11. "Direct binding of the human homologue of the Drosophila disc large tumor suppressor gene to seven-pass transmembrane proteins, tumor endothelial marker 5 (TEM5), and a novel TEM5-like protein."
    Yamamoto Y., Irie K., Asada M., Mino A., Mandai K., Takai Y.
    Oncogene 23:3889-3897(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, INTERACTION WITH DLG1.

Entry informationi

Entry nameiGP124_HUMAN
AccessioniPrimary (citable) accession number: Q96PE1
Secondary accession number(s): A6H8W3
, D3DSW4, Q8N3R1, Q8TEM3, Q96KB2, Q9P1Z7, Q9UFY4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: January 20, 2009
Last modified: November 26, 2014
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3