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Protein

2-acylglycerol O-acyltransferase 1

Gene

MOGAT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Probably not involved in absorption of dietary fat in the small intestine (By similarity).By similarity

Catalytic activityi

Acyl-CoA + 2-acylglycerol = CoA + diacylglycerol.

Pathwayi: triacylglycerol biosynthesis

This protein is involved in the pathway triacylglycerol biosynthesis, which is part of Glycerolipid metabolism.
View all proteins of this organism that are known to be involved in the pathway triacylglycerol biosynthesis and in Glycerolipid metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Glycerol metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BRENDAi2.3.1.22. 2681.
UniPathwayiUPA00282.

Names & Taxonomyi

Protein namesi
Recommended name:
2-acylglycerol O-acyltransferase 1 (EC:2.3.1.22)
Alternative name(s):
Acyl-CoA:monoacylglycerol acyltransferase 1
Short name:
MGAT1
Diacylglycerol O-acyltransferase candidate 2
Short name:
hDC2
Diacylglycerol acyltransferase 2-like protein 1
Monoacylglycerol O-acyltransferase 1
Gene namesi
Name:MOGAT1
Synonyms:DC2, DGAT2L1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:18210. MOGAT1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei18 – 3821HelicalSequence analysisAdd
BLAST
Transmembranei40 – 6021HelicalSequence analysisAdd
BLAST
Transmembranei132 – 15221HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27305.

Polymorphism and mutation databases

BioMutaiMOGAT1.
DMDMi292495019.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3353352-acylglycerol O-acyltransferase 1PRO_0000249058Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi121 – 1211N-linked (GlcNAc...)Sequence analysis
Glycosylationi125 – 1251N-linked (GlcNAc...)Sequence analysis
Glycosylationi180 – 1801N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ96PD6.
PRIDEiQ96PD6.

PTM databases

PhosphoSiteiQ96PD6.

Expressioni

Gene expression databases

BgeeiQ96PD6.
CleanExiHS_MOGAT1.
GenevisibleiQ96PD6. HS.

Organism-specific databases

HPAiHPA049944.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000406674.

Structurei

3D structure databases

ProteinModelPortaliQ96PD6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0831. Eukaryota.
ENOG410XTG3. LUCA.
GeneTreeiENSGT00750000117391.
HOGENOMiHOG000179738.
HOVERGENiHBG065791.
InParanoidiQ96PD6.
KOiK14458.
OMAiWFLYVPY.
OrthoDBiEOG7KH9KB.
PhylomeDBiQ96PD6.
TreeFamiTF314707.

Family and domain databases

InterProiIPR007130. DAGAT.
[Graphical view]
PfamiPF03982. DAGAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96PD6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVEFAPLNI QLARRLQTVA VLQWVLKYLL LGPMSIGITV MLIIHNYLFL
60 70 80 90 100
YIPYLMWLYF DWHTPERGGR RSSWIKNWTL WKHFKDYFPI HLIKTQDLDP
110 120 130 140 150
SHNYIFGFHP HGIMAVGAFG NFSVNYSDFK DLFPGFTSYL HVLPLWFWCP
160 170 180 190 200
VFREYVMSVG LVSVSKKSVS YMVSKEGGGN ISVIVLGGAK ESLDAHPGKF
210 220 230 240 250
TLFIRQRKGF VKIALTHGAS LVPVVSFGEN ELFKQTDNPE GSWIRTVQNK
260 270 280 290 300
LQKIMGFALP LFHARGVFQY NFGLMTYRKA IHTVVGRPIP VRQTLNPTQE
310 320 330
QIEELHQTYM EELRKLFEEH KGKYGIPEHE TLVLK
Length:335
Mass (Da):38,812
Last modified:March 23, 2010 - v2
Checksum:iA76F13FB34CEE78B
GO

Sequence cautioni

The sequence AAX81987.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti27 – 315KYLLL → SFLT in AAK84178 (PubMed:11481335).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti13 – 131A → T.
Corresponds to variant rs35959734 [ dbSNP | Ensembl ].
VAR_055695
Natural varianti163 – 1631S → P.
Corresponds to variant rs1868024 [ dbSNP | Ensembl ].
VAR_027389

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF384163 mRNA. Translation: AAK84178.1.
AC104772 Genomic DNA. Translation: AAX81987.1. Sequence problems.
BN000154 mRNA. Translation: CAD89265.1.
CCDSiCCDS46524.1.
RefSeqiNP_477513.2. NM_058165.2.
UniGeneiHs.344090.

Genome annotation databases

EnsembliENST00000446656; ENSP00000406674; ENSG00000124003.
GeneIDi116255.
KEGGihsa:116255.
UCSCiuc010fws.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF384163 mRNA. Translation: AAK84178.1.
AC104772 Genomic DNA. Translation: AAX81987.1. Sequence problems.
BN000154 mRNA. Translation: CAD89265.1.
CCDSiCCDS46524.1.
RefSeqiNP_477513.2. NM_058165.2.
UniGeneiHs.344090.

3D structure databases

ProteinModelPortaliQ96PD6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000406674.

PTM databases

PhosphoSiteiQ96PD6.

Polymorphism and mutation databases

BioMutaiMOGAT1.
DMDMi292495019.

Proteomic databases

PaxDbiQ96PD6.
PRIDEiQ96PD6.

Protocols and materials databases

DNASUi116255.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000446656; ENSP00000406674; ENSG00000124003.
GeneIDi116255.
KEGGihsa:116255.
UCSCiuc010fws.2. human.

Organism-specific databases

CTDi116255.
GeneCardsiMOGAT1.
H-InvDBHIX0029845.
HGNCiHGNC:18210. MOGAT1.
HPAiHPA049944.
MIMi610268. gene.
neXtProtiNX_Q96PD6.
PharmGKBiPA27305.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0831. Eukaryota.
ENOG410XTG3. LUCA.
GeneTreeiENSGT00750000117391.
HOGENOMiHOG000179738.
HOVERGENiHBG065791.
InParanoidiQ96PD6.
KOiK14458.
OMAiWFLYVPY.
OrthoDBiEOG7KH9KB.
PhylomeDBiQ96PD6.
TreeFamiTF314707.

Enzyme and pathway databases

UniPathwayiUPA00282.
BRENDAi2.3.1.22. 2681.

Miscellaneous databases

GenomeRNAii116255.
NextBioi79856.
PROiQ96PD6.
SOURCEiSearch...

Gene expression databases

BgeeiQ96PD6.
CleanExiHS_MOGAT1.
GenevisibleiQ96PD6. HS.

Family and domain databases

InterProiIPR007130. DAGAT.
[Graphical view]
PfamiPF03982. DAGAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members."
    Cases S., Stone S.J., Zhou P., Yen C.-L.E., Tow B., Lardizabal K.D., Voelker T., Farese R.V. Jr.
    J. Biol. Chem. 276:38870-38876(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Kidney.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Genomic organization of the DGAT2/MOGAT gene family in cattle (Bos taurus) and other mammals."
    Winter A., van Eckeveld M., Bininda-Emonds O.R.P., Habermann F.A., Fries R.
    Cytogenet. Genome Res. 102:42-47(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiMOGT1_HUMAN
AccessioniPrimary (citable) accession number: Q96PD6
Secondary accession number(s): Q6IEE5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: March 23, 2010
Last modified: March 16, 2016
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.