Q96PD6 (MOGT1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
2-acylglycerol O-acyltransferase 1
EC=2.3.1.22

Alternative name(s):
Acyl-CoA:monoacylglycerol acyltransferase 1
Short name=MGAT1
Diacylglycerol O-acyltransferase candidate 2
Short name=hDC2
Diacylglycerol acyltransferase 2-like protein 1
Monoacylglycerol O-acyltransferase 1

Gene names

Name:	MOGAT1
Synonyms:	DC2, DGAT2L1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	335 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Probably not involved in absorption of dietary fat in the small intestine By similarity.
Catalytic activity	Acyl-CoA + 2-acylglycerol = CoA + diacylglycerol.
Pathway	Glycerolipid metabolism; triacylglycerol biosynthesis.
Subcellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the diacylglycerol acyltransferase family.
Sequence caution	The sequence AAX81987.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Glycerol metabolism Lipid metabolism Lipid synthesis
Cellular component	Endoplasmic reticulum Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	Acyltransferase Transferase
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	glycerol metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	2-acylglycerol O-acyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 335	335	2-acylglycerol O-acyltransferase 1		PRO_0000249058
Regions
	Transmembrane	18 – 38	21	Helical; Potential
	Transmembrane	40 – 60	21	Helical; Potential
	Transmembrane	132 – 152	21	Helical; Potential
Amino acid modifications
	Glycosylation	121	1	N-linked (GlcNAc...) Potential
	Glycosylation	125	1	N-linked (GlcNAc...) Potential
	Glycosylation	180	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	13	1	A → T. Corresponds to variant rs35959734 [ dbSNP | Ensembl ].		VAR_055695
	Natural variant	163	1	S → P. Corresponds to variant rs1868024 [ dbSNP | Ensembl ].		VAR_027389
Experimental info
	Sequence conflict	27 – 31	5	KYLLL → SFLT in AAK84178. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q96PD6 [UniParc]. Last modified March 23, 2010. Version 2. Checksum: A76F13FB34CEE78B	FASTA	335	38,812
	10 20 30 40 50 60 MKVEFAPLNI QLARRLQTVA VLQWVLKYLL LGPMSIGITV MLIIHNYLFL YIPYLMWLYF 70 80 90 100 110 120 DWHTPERGGR RSSWIKNWTL WKHFKDYFPI HLIKTQDLDP SHNYIFGFHP HGIMAVGAFG 130 140 150 160 170 180 NFSVNYSDFK DLFPGFTSYL HVLPLWFWCP VFREYVMSVG LVSVSKKSVS YMVSKEGGGN 190 200 210 220 230 240 ISVIVLGGAK ESLDAHPGKF TLFIRQRKGF VKIALTHGAS LVPVVSFGEN ELFKQTDNPE 250 260 270 280 290 300 GSWIRTVQNK LQKIMGFALP LFHARGVFQY NFGLMTYRKA IHTVVGRPIP VRQTLNPTQE 310 320 330 QIEELHQTYM EELRKLFEEH KGKYGIPEHE TLVLK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members." Cases S., Stone S.J., Zhou P., Yen C.-L.E., Tow B., Lardizabal K.D., Voelker T., Farese R.V. Jr. J. Biol. Chem. 276:38870-38876(2001) [PubMed: 11481335] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Kidney.
[2]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed: 15815621] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Genomic organization of the DGAT2/MOGAT gene family in cattle (Bos taurus) and other mammals." Winter A., van Eckeveld M., Bininda-Emonds O.R.P., Habermann F.A., Fries R. Cytogenet. Genome Res. 102:42-47(2003) [PubMed: 14970677] [Abstract] Cited for: IDENTIFICATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF384163 mRNA. Translation: AAK84178.1. AC104772 Genomic DNA. Translation: AAX81987.1. Sequence problems. BN000154 mRNA. Translation: CAD89265.1.
IPI	IPI00943252.
RefSeq	NP_477513.2. NM_058165.2.
UniGene	Hs.344090.
3D structure databases
ProteinModelPortal	Q96PD6.
ModBase	Search...
Protein-protein interaction databases
STRING	Q96PD6.
Polymorphism databases
DMDM	292495019.
Proteomic databases
PRIDE	Q96PD6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000264412; ENSP00000264412; ENSG00000124003.
GeneID	116255.
KEGG	hsa:116255.
UCSC	uc010fws.1. human.
Organism-specific databases
CTD	116255.
GeneCards	GC02P223536.
H-InvDB	HIX0029845.
HGNC	HGNC:18210. MOGAT1.
MIM	610268. gene.
neXtProt	NX_Q96PD6.
PharmGKB	PA27305.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG16615.
GeneTree	ENSGT00550000074276.
HOVERGEN	HBG065791.
InParanoid	Q96PD6.
OMA	GVFQYNF.
OrthoDB	EOG4BP1C4.
PhylomeDB	Q96PD6.
Gene expression databases
ArrayExpress	Q96PD6.
Bgee	Q96PD6.
CleanEx	HS_MOGAT1.
Genevestigator	Q96PD6.
Family and domain databases
InterPro	IPR007130. DAGAT. [Graphical view]
KO	K14458.
PANTHER	PTHR12317. DAGAT. 1 hit.
Pfam	PF03982. DAGAT. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	79856.
SOURCE	Search...

Entry information

Entry name

MOGT1_HUMAN

Accession

Primary (citable) accession number: Q96PD6
Secondary accession number(s): Q6IEE5

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 5, 2006
Last sequence update:	March 23, 2010
Last modified:	January 25, 2012
This is version 64 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.