Reviewed, UniProtKB/Swiss-Prot Q96PD6 (MOGT1_HUMAN)

Names and origin

Protein names

Recommended name:
    2-acylglycerol O-acyltransferase 1
    EC=2.3.1.22
Alternative name(s):
    Monoacylglycerol O-acyltransferase 1
    Acyl CoA:monoacylglycerol acyltransferase 1
      Short name=MGAT1
    Diacylglycerol acyltransferase 2-like protein 1
    Diacylglycerol O-acyltransferase candidate 2
      Short name=hDC2

Gene names

Name:	MOGAT1
Synonyms:	DC2, DGAT2L1

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	334 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Probably not involved in absorption of dietary fat in the small intestine By similarity.
Catalytic activity	Acyl-CoA + 2-acylglycerol = CoA + diacylglycerol.
Pathway	Glycerolipid metabolism; triacylglycerol biosynthesis.
Subcellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the diacylglycerol acyltransferase family.
Sequence caution	The sequence CAD89265.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Glycerol metabolism Lipid metabolism Lipid synthesis
Cellular component	Endoplasmic reticulum Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane
Molecular function	Acyltransferase Transferase
PTM	Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycerol metabolic process Inferred from electronic annotation. Source: UniProtKB-KW lipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endoplasmic reticulum Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	2-acylglycerol O-acyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 334	334	2-acylglycerol O-acyltransferase 1		PRO_0000249058
Regions
	Transmembrane	18 – 38	21	Potential
	Transmembrane	40 – 59	20	Potential
	Transmembrane	131 – 151	21	Potential
Amino acid modifications
	Glycosylation	120	1	N-linked (GlcNAc...) Potential
	Glycosylation	124	1	N-linked (GlcNAc...) Potential
	Glycosylation	179	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	13	1	A → T: dbSNP rs35959734.		VAR_055695
	Natural variant	162	1	S → P: dbSNP rs1868024.		VAR_027389

Sequences

	Sequence		Length	Mass (Da)
	Q96PD6-1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: DFADC0728701B668	FASTA	334	38,630
	10 20 30 40 50 60 MKVEFAPLNI QLARRLQTVA VLQWVLSFLT GPMSIGITVM LIIHNYLFLY IPYLMWLYFD 70 80 90 100 110 120 WHTPERGGRR SSWIKNWTLW KHFKDYFPIH LIKTQDLDPS HNYIFGFHPH GIMAVGAFGN 130 140 150 160 170 180 FSVNYSDFKD LFPGFTSYLH VLPLWFWCPV FREYVMSVGL VSVSKKSVSY MVSKEGGGNI 190 200 210 220 230 240 SVIVLGGAKE SLDAHPGKFT LFIRQRKGFV KIALTHGASL VPVVSFGENE LFKQTDNPEG 250 260 270 280 290 300 SWIRTVQNKL QKIMGFALPL FHARGVFQYN FGLMTYRKAI HTVVGRPIPV RQTLNPTQEQ 310 320 330 IEELHQTYME ELRKLFEEHK GKYGIPEHET LVLK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members." Cases S., Stone S.J., Zhou P., Yen C.-L.E., Tow B., Lardizabal K.D., Voelker T., Farese R.V. Jr. J. Biol. Chem. 276:38870-38876(2001) [PubMed: 11481335] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Kidney.
[2]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed: 15815621] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Genomic organization of the DGAT2/MOGAT gene family in cattle (Bos taurus) and other mammals." Winter A., van Eckeveld M., Bininda-Emonds O.R.P., Habermann F.A., Fries R. Cytogenet. Genome Res. 102:42-47(2003) [PubMed: 14970677] [Abstract] Cited for: IDENTIFICATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF384163 mRNA. Translation: AAK84178.1. AC104772 Genomic DNA. Translation: AAX81987.1. BN000154 mRNA. Translation: CAD89265.1. Sequence problems.
IPI	IPI00943252.
RefSeq	NP_477513.2.
UniGene	Hs.344090
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q96PD6.
Proteomic databases
PRIDE	Q96PD6.
Genome annotation databases
Ensembl	ENST00000264412; ENSP00000264412; ENSG00000124003; Homo sapiens. [Genome view]
GeneID	116255.
KEGG	hsa:116255.
UCSC	uc010fws.1. human.
Organism-specific databases
CTD	116255.
GeneCards	GC02P223244.
HGNC	HGNC:18210. MOGAT1.
MIM	610268. gene.
PharmGKB	PA27305.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG16615.
HOVERGEN	Q96PD6.
InParanoid	Q96PD6.
PhylomeDB	Q96PD6.
Enzyme and pathway databases
BRENDA	2.3.1.22. 247.
Gene expression databases
ArrayExpress	Q96PD6.
Bgee	Q96PD6.
CleanEx	HS_MOGAT1.
Genevestigator	Q96PD6.
Family and domain databases
InterPro	IPR007130. DAGAT. [Graphical view]
PANTHER	PTHR12317. DAGAT. 1 hit.
ProtoNet	Search...
Other Resources
NextBio	79856.
SOURCE	Search...

Entry information

Entry name

MOGT1_HUMAN

Accession

Primary (citable) accession number: Q96PD6
Secondary accession number(s): Q6IEE5

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 5, 2006
Last sequence update:	December 1, 2001
Last modified:	February 9, 2010
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.