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Protein

2-acylglycerol O-acyltransferase 1

Gene

MOGAT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Probably not involved in absorption of dietary fat in the small intestine (By similarity).By similarity

Catalytic activityi

Acyl-CoA + 2-acylglycerol = CoA + diacylglycerol.

Pathwayi: triacylglycerol biosynthesis

This protein is involved in the pathway triacylglycerol biosynthesis, which is part of Glycerolipid metabolism.
View all proteins of this organism that are known to be involved in the pathway triacylglycerol biosynthesis and in Glycerolipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processGlycerol metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BRENDAi2.3.1.22 2681
ReactomeiR-HSA-75109 Triglyceride biosynthesis
UniPathwayiUPA00282

Names & Taxonomyi

Protein namesi
Recommended name:
2-acylglycerol O-acyltransferase 1 (EC:2.3.1.22)
Alternative name(s):
Acyl-CoA:monoacylglycerol acyltransferase 1
Short name:
MGAT1
Diacylglycerol O-acyltransferase candidate 2
Short name:
hDC2
Diacylglycerol acyltransferase 2-like protein 1
Monoacylglycerol O-acyltransferase 1
Gene namesi
Name:MOGAT1
Synonyms:DC2, DGAT2L1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000124003.12
HGNCiHGNC:18210 MOGAT1
MIMi610268 gene
neXtProtiNX_Q96PD6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei18 – 38HelicalSequence analysisAdd BLAST21
Transmembranei40 – 60HelicalSequence analysisAdd BLAST21
Transmembranei132 – 152HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi116255
OpenTargetsiENSG00000124003
PharmGKBiPA27305

Polymorphism and mutation databases

BioMutaiMOGAT1
DMDMi292495019

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002490581 – 3352-acylglycerol O-acyltransferase 1Add BLAST335

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi121N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi125N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi180N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ96PD6
PeptideAtlasiQ96PD6
PRIDEiQ96PD6

PTM databases

iPTMnetiQ96PD6
PhosphoSitePlusiQ96PD6

Expressioni

Gene expression databases

BgeeiENSG00000124003
CleanExiHS_MOGAT1
GenevisibleiQ96PD6 HS

Organism-specific databases

HPAiHPA049944

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000406674

Structurei

3D structure databases

ProteinModelPortaliQ96PD6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0831 Eukaryota
ENOG410XTG3 LUCA
GeneTreeiENSGT00750000117391
HOGENOMiHOG000179738
HOVERGENiHBG065791
InParanoidiQ96PD6
KOiK14458
OMAiIMGFALP
OrthoDBiEOG091G0BGQ
PhylomeDBiQ96PD6
TreeFamiTF314707

Family and domain databases

InterProiView protein in InterPro
IPR007130 DAGAT
PfamiView protein in Pfam
PF03982 DAGAT, 1 hit

Sequencei

Sequence statusi: Complete.

Q96PD6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVEFAPLNI QLARRLQTVA VLQWVLKYLL LGPMSIGITV MLIIHNYLFL
60 70 80 90 100
YIPYLMWLYF DWHTPERGGR RSSWIKNWTL WKHFKDYFPI HLIKTQDLDP
110 120 130 140 150
SHNYIFGFHP HGIMAVGAFG NFSVNYSDFK DLFPGFTSYL HVLPLWFWCP
160 170 180 190 200
VFREYVMSVG LVSVSKKSVS YMVSKEGGGN ISVIVLGGAK ESLDAHPGKF
210 220 230 240 250
TLFIRQRKGF VKIALTHGAS LVPVVSFGEN ELFKQTDNPE GSWIRTVQNK
260 270 280 290 300
LQKIMGFALP LFHARGVFQY NFGLMTYRKA IHTVVGRPIP VRQTLNPTQE
310 320 330
QIEELHQTYM EELRKLFEEH KGKYGIPEHE TLVLK
Length:335
Mass (Da):38,812
Last modified:March 23, 2010 - v2
Checksum:iA76F13FB34CEE78B
GO

Sequence cautioni

The sequence AAX81987 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti27 – 31KYLLL → SFLT in AAK84178 (PubMed:11481335).Curated5

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05569513A → T. Corresponds to variant dbSNP:rs35959734Ensembl.1
Natural variantiVAR_027389163S → P. Corresponds to variant dbSNP:rs1868024Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF384163 mRNA Translation: AAK84178.1
AC104772 Genomic DNA Translation: AAX81987.1 Sequence problems.
BN000154 mRNA Translation: CAD89265.1
CCDSiCCDS46524.1
RefSeqiNP_477513.2, NM_058165.2
UniGeneiHs.344090

Genome annotation databases

EnsembliENST00000446656; ENSP00000406674; ENSG00000124003
GeneIDi116255
KEGGihsa:116255
UCSCiuc010fws.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMOGT1_HUMAN
AccessioniPrimary (citable) accession number: Q96PD6
Secondary accession number(s): Q6IEE5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: March 23, 2010
Last modified: February 28, 2018
This is version 106 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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