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Q96PD5

- PGRP2_HUMAN

UniProt

Q96PD5 - PGRP2_HUMAN

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Protein

N-acetylmuramoyl-L-alanine amidase

Gene

PGLYRP2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May play a scavenger role by digesting biologically active peptidoglycan (PGN) into biologically inactive fragments. Has no direct bacteriolytic activity.1 Publication

Catalytic activityi

Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.

Cofactori

Zinc.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi411 – 4111ZincBy similarity
Metal bindingi447 – 4471ZincBy similarity
Metal bindingi522 – 5221ZincBy similarity
Metal bindingi530 – 5301ZincBy similarity

GO - Molecular functioni

  1. N-acetylmuramoyl-L-alanine amidase activity Source: UniProtKB
  2. peptidoglycan binding Source: UniProtKB
  3. peptidoglycan receptor activity Source: UniProtKB
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. defense response to Gram-positive bacterium Source: UniProtKB
  2. detection of bacterium Source: UniProtKB
  3. growth of symbiont in host Source: Ensembl
  4. innate immune response Source: UniProtKB
  5. negative regulation of interferon-gamma production Source: Ensembl
  6. negative regulation of natural killer cell differentiation involved in immune response Source: Ensembl
  7. pattern recognition receptor signaling pathway Source: GOC
  8. peptide amidation Source: UniProtKB
  9. peptidoglycan catabolic process Source: InterPro
  10. regulation of inflammatory response Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Immunity

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BRENDAi3.5.1.28. 2681.

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetylmuramoyl-L-alanine amidase (EC:3.5.1.28)
Alternative name(s):
Peptidoglycan recognition protein 2
Peptidoglycan recognition protein long
Short name:
PGRP-L
Gene namesi
Name:PGLYRP2
Synonyms:PGLYRPL, PGRPL
ORF Names:UNQ3103/PRO10102
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:30013. PGLYRP2.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProtKB
  2. intracellular Source: UniProtKB
  3. membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi411 – 4111H → A: No effect on amidase activity. 1 Publication
Mutagenesisi419 – 4191C → A: Abolishes amidase activity. 1 Publication
Mutagenesisi436 – 4361H → A: No effect on amidase activity. 1 Publication
Mutagenesisi442 – 4421W → A: Reduced amidase activity. 1 Publication
Mutagenesisi447 – 4471Y → A: Abolishes amidase activity.
Mutagenesisi530 – 5301C → S: Abolishes amidase activity. 1 Publication

Organism-specific databases

PharmGKBiPA134929965.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 21212 PublicationsAdd
BLAST
Chaini22 – 576555N-acetylmuramoyl-L-alanine amidasePRO_0000023920Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi77 – 771N-linked (GlcNAc...)1 Publication
Modified residuei239 – 2391Phosphoserine1 Publication
Modified residuei274 – 2741Deamidated asparagine1 Publication
Modified residuei322 – 3221Deamidated asparagine1 Publication
Glycosylationi367 – 3671N-linked (GlcNAc...)2 Publications
Disulfide bondi419 ↔ 4251 Publication
Glycosylationi485 – 4851N-linked (GlcNAc...)3 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ96PD5.
PeptideAtlasiQ96PD5.
PRIDEiQ96PD5.

Expressioni

Tissue specificityi

Strongly expressed in liver and fetal liver, and secreted into serum. Expressed to a much lesser extent in transverse colon, lymph nodes, heart, thymus, pancreas, descending colon, stomach and testis. Isoform 2 is not detected in the liver or serum.2 Publications

Gene expression databases

BgeeiQ96PD5.
CleanExiHS_PGLYRP2.
ExpressionAtlasiQ96PD5. baseline and differential.
GenevestigatoriQ96PD5.

Organism-specific databases

HPAiCAB033468.
HPA043568.
HPA046311.

Interactioni

Protein-protein interaction databases

IntActiQ96PD5. 1 interaction.
STRINGi9606.ENSP00000345968.

Structurei

3D structure databases

ProteinModelPortaliQ96PD5.
SMRiQ96PD5. Positions 379-545.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG5479.
GeneTreeiENSGT00390000016833.
HOGENOMiHOG000276878.
HOVERGENiHBG053578.
InParanoidiQ96PD5.
KOiK01446.
OMAiMAFLNGA.
OrthoDBiEOG757CZ5.
PhylomeDBiQ96PD5.
TreeFamiTF323898.

Family and domain databases

Gene3Di3.40.80.10. 1 hit.
InterProiIPR002502. Amidase_domain.
IPR015510. PGRP.
IPR006619. PGRP_domain_met/bac.
[Graphical view]
PANTHERiPTHR11022. PTHR11022. 1 hit.
PfamiPF01510. Amidase_2. 1 hit.
[Graphical view]
SMARTiSM00644. Ami_2. 1 hit.
SM00701. PGRP. 1 hit.
[Graphical view]
SUPFAMiSSF55846. SSF55846. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96PD5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQGVLWILL GLLLWSDPGT ASLPLLMDSV IQALAELEQK VPAAKTRHTA
60 70 80 90 100
SAWLMSAPNS GPHNRLYHFL LGAWSLNATE LDPCPLSPEL LGLTKEVARH
110 120 130 140 150
DVREGKEYGV VLAPDGSTVA VEPLLAGLEA GLQGRRVINL PLDSMAAPWE
160 170 180 190 200
TGDTFPDVVA IAPDVRATSS PGLRDGSPDV TTADIGANTP DATKGCPDVQ
210 220 230 240 250
ASLPDAKAKS PPTMVDSLLA VTLAGNLGLT FLRGSQTQSH PDLGTEGCWD
260 270 280 290 300
QLSAPRTFTL LDPKASLLTM AFLNGALDGV ILGDYLSRTP EPRPSLSHLL
310 320 330 340 350
SQYYGAGVAR DPGFRSNFRR QNGAALTSAS ILAQQVWGTL VLLQRLEPVH
360 370 380 390 400
LQLQCMSQEQ LAQVAANATK EFTEAFLGCP AIHPRCRWGA APYRGRPKLL
410 420 430 440 450
QLPLGFLYVH HTYVPAPPCT DFTRCAANMR SMQRYHQDTQ GWGDIGYSFV
460 470 480 490 500
VGSDGYVYEG RGWHWVGAHT LGHNSRGFGV AIVGNYTAAL PTEAALRTVR
510 520 530 540 550
DTLPSCAVRA GLLRPDYALL GHRQLVRTDC PGDALFDLLR TWPHFTATVK
560 570
PRPARSVSKR SRREPPPRTL PATDLQ

Note: Major isoform.

Length:576
Mass (Da):62,217
Last modified:December 1, 2001 - v1
Checksum:i73EA8713DC54F85A
GO
Isoform 2 (identifier: Q96PD5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     548-576: TVKPRPARSVSKRSRREPPPRTLPATDLQ → VSLRSLHYTA...TQPACPFPSS

Note: May be due to an intron retention. No experimental confirmation available.

Show »
Length:634
Mass (Da):68,000
Checksum:i93FFCAFB353E47A4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti124 – 1241L → P in AAI44239. (PubMed:15489334)Curated
Sequence conflicti448 – 4481S → G in BAB71034. (PubMed:14702039)Curated
Sequence conflicti562 – 5621R → G in BAF82104. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti46 – 461T → A.1 Publication
Corresponds to variant rs3813135 [ dbSNP | Ensembl ].
VAR_050498
Natural varianti99 – 991R → Q.1 Publication
Corresponds to variant rs733731 [ dbSNP | Ensembl ].
VAR_050499
Natural varianti257 – 2571T → N.
Corresponds to variant rs28404490 [ dbSNP | Ensembl ].
VAR_050500
Natural varianti270 – 2701M → K.1 Publication
Corresponds to variant rs892145 [ dbSNP | Ensembl ].
VAR_050501
Natural varianti394 – 3941R → Q.2 Publications
Corresponds to variant rs34440547 [ dbSNP | Ensembl ].
VAR_055231
Natural varianti476 – 4761R → W.
Corresponds to variant rs2304200 [ dbSNP | Ensembl ].
VAR_050502

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei548 – 57629TVKPR…ATDLQ → VSLRSLHYTARRPSVYTSST RPLPPACNSCARTASARPPT SRRHVYSGNLGPAFAGHSAG NIPDPVTSAYAASAQPQTQP ACPFPSS in isoform 2. 2 PublicationsVSP_008964Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF384856 mRNA. Translation: AAL05629.1.
AB073610 mRNA. Translation: BAD38647.1.
AY358156 mRNA. Translation: AAQ88523.1.
AK055882 mRNA. Translation: BAB71034.1.
AK289415 mRNA. Translation: BAF82104.1.
AK292292 mRNA. Translation: BAF84981.1.
CH471106 Genomic DNA. Translation: EAW84482.1.
CH471106 Genomic DNA. Translation: EAW84483.1.
BC136551 mRNA. Translation: AAI36552.1.
BC136552 mRNA. Translation: AAI36553.1.
BC144238 mRNA. Translation: AAI44239.1.
CCDSiCCDS12330.2. [Q96PD5-1]
RefSeqiNP_443122.3. NM_052890.3. [Q96PD5-1]
XP_006722696.1. XM_006722633.1. [Q96PD5-2]
UniGeneiHs.282244.

Genome annotation databases

EnsembliENST00000292609; ENSP00000292609; ENSG00000161031. [Q96PD5-2]
ENST00000340880; ENSP00000345968; ENSG00000161031. [Q96PD5-1]
GeneIDi114770.
KEGGihsa:114770.
UCSCiuc002nbf.4. human. [Q96PD5-1]
uc002nbg.3. human. [Q96PD5-2]

Polymorphism databases

DMDMi38258222.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF384856 mRNA. Translation: AAL05629.1 .
AB073610 mRNA. Translation: BAD38647.1 .
AY358156 mRNA. Translation: AAQ88523.1 .
AK055882 mRNA. Translation: BAB71034.1 .
AK289415 mRNA. Translation: BAF82104.1 .
AK292292 mRNA. Translation: BAF84981.1 .
CH471106 Genomic DNA. Translation: EAW84482.1 .
CH471106 Genomic DNA. Translation: EAW84483.1 .
BC136551 mRNA. Translation: AAI36552.1 .
BC136552 mRNA. Translation: AAI36553.1 .
BC144238 mRNA. Translation: AAI44239.1 .
CCDSi CCDS12330.2. [Q96PD5-1 ]
RefSeqi NP_443122.3. NM_052890.3. [Q96PD5-1 ]
XP_006722696.1. XM_006722633.1. [Q96PD5-2 ]
UniGenei Hs.282244.

3D structure databases

ProteinModelPortali Q96PD5.
SMRi Q96PD5. Positions 379-545.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q96PD5. 1 interaction.
STRINGi 9606.ENSP00000345968.

Polymorphism databases

DMDMi 38258222.

Proteomic databases

PaxDbi Q96PD5.
PeptideAtlasi Q96PD5.
PRIDEi Q96PD5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000292609 ; ENSP00000292609 ; ENSG00000161031 . [Q96PD5-2 ]
ENST00000340880 ; ENSP00000345968 ; ENSG00000161031 . [Q96PD5-1 ]
GeneIDi 114770.
KEGGi hsa:114770.
UCSCi uc002nbf.4. human. [Q96PD5-1 ]
uc002nbg.3. human. [Q96PD5-2 ]

Organism-specific databases

CTDi 114770.
GeneCardsi GC19M015579.
HGNCi HGNC:30013. PGLYRP2.
HPAi CAB033468.
HPA043568.
HPA046311.
MIMi 608199. gene.
neXtProti NX_Q96PD5.
PharmGKBi PA134929965.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5479.
GeneTreei ENSGT00390000016833.
HOGENOMi HOG000276878.
HOVERGENi HBG053578.
InParanoidi Q96PD5.
KOi K01446.
OMAi MAFLNGA.
OrthoDBi EOG757CZ5.
PhylomeDBi Q96PD5.
TreeFami TF323898.

Enzyme and pathway databases

BRENDAi 3.5.1.28. 2681.

Miscellaneous databases

GeneWikii PGLYRP2.
GenomeRNAii 114770.
NextBioi 35463706.
PROi Q96PD5.
SOURCEi Search...

Gene expression databases

Bgeei Q96PD5.
CleanExi HS_PGLYRP2.
ExpressionAtlasi Q96PD5. baseline and differential.
Genevestigatori Q96PD5.

Family and domain databases

Gene3Di 3.40.80.10. 1 hit.
InterProi IPR002502. Amidase_domain.
IPR015510. PGRP.
IPR006619. PGRP_domain_met/bac.
[Graphical view ]
PANTHERi PTHR11022. PTHR11022. 1 hit.
Pfami PF01510. Amidase_2. 1 hit.
[Graphical view ]
SMARTi SM00644. Ami_2. 1 hit.
SM00701. PGRP. 1 hit.
[Graphical view ]
SUPFAMi SSF55846. SSF55846. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Peptidoglycan recognition proteins: a novel family of four human innate immunity pattern recognition molecules."
    Liu C., Xu Z., Gupta D., Dziarski R.
    J. Biol. Chem. 276:34686-34694(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  2. "Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas."
    Yamada S., Ohira M., Horie H., Ando K., Takayasu H., Suzuki Y., Sugano S., Hirata T., Goto T., Matsunaga T., Hiyama E., Hayashi Y., Ando H., Suita S., Kaneko M., Sasaki F., Hashizume K., Ohnuma N., Nakagawara A.
    Oncogene 23:5901-5911(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLN-394.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ALA-46; GLN-99; LYS-270 AND GLN-394.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Liver, Mammary gland and Testis.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  7. "Characterization of human serum N-acetylmuramyl-L-alanine amidase purified by affinity chromatography."
    De Pauw P., Neyt C., Vanderwinkel E., Wattiez R., Falmagne P.
    Protein Expr. Purif. 6:371-378(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 22-36.
  8. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 22-36.
  9. "Identification of serum N-acetylmuramoyl-l-alanine amidase as liver peptidoglycan recognition protein 2."
    Zhang Y., van der Fits L., Voerman J.S., Melief M.-J., Laman J.D., Wang M., Wang H., Wang M., Li X., Walls C.D., Gupta D., Dziarski R.
    Biochim. Biophys. Acta 1752:34-46(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, TISSUE SPECIFICITY, PHOSPHORYLATION AT SER-239, DEAMIDATION AT ASN-274 AND ASN-322, DISULFIDE BONDS.
    Tissue: Liver and Serum.
  10. "Human peptidoglycan recognition protein-L is an N-acetylmuramoyl-L-alanine amidase."
    Wang Z.-M., Li X., Cocklin R.R., Wang M., Wang M., Fukase K., Inamura S., Kusumoto S., Gupta D., Dziarski R.
    J. Biol. Chem. 278:49044-49052(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION BY MASS SPECTROMETRY, MUTAGENESIS OF HIS-411; CYS-419; HIS-436; TRP-442 AND CYS-530.
  11. "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."
    Zhang H., Li X.-J., Martin D.B., Aebersold R.
    Nat. Biotechnol. 21:660-666(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION AT ASN-485.
  12. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-77; ASN-367 AND ASN-485.
    Tissue: Plasma.
  13. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-367 AND ASN-485.
    Tissue: Liver.

Entry informationi

Entry nameiPGRP2_HUMAN
AccessioniPrimary (citable) accession number: Q96PD5
Secondary accession number(s): A8K050
, A8K8C7, B2RMZ2, B7ZM33, Q68CK1, Q96N74, Q9UC60
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3