Q96PD4 (IL17F_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Interleukin-17F
Short name=IL-17F

Alternative name(s):
Cytokine ML-1
Interleukin-24
Short name=IL-24

Gene names

Name:	IL17F
Synonyms:	IL24

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	163 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Stimulates the production of other cytokines such as IL-6, IL-8 and granulocyte colony-stimulating factor, and can regulate cartilage matrix turnover. Stimulates PBMC and T-cell proliferation. Inhibits angiogenesis.
Subunit structure	Homodimer; disulfide-linked. Ref.7
Subcellular location	Secreted.
Tissue specificity	Expressed in activated, but not resting, CD4+ T-cells and activated monocytes.
Involvement in disease	Familial candidiasis 6 (CANDF6) [MIM:613956]: A primary immunodeficiency disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.8
Sequence similarities	Belongs to the IL-17 family.
Sequence caution	The sequence AAL14427.1 differs from that shown. Reason: Intron retention. The sequence CAD92646.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Disease	Disease mutation
Domain	Signal
Molecular function	Cytokine
PTM	Disulfide bond Glycoprotein
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	cartilage development Inferred from direct assay Ref.6. Source: UniProtKB inflammatory response Inferred from electronic annotation. Source: InterPro lymphotoxin A biosynthetic process Inferred from direct assay Ref.1. Source: UniProtKB negative regulation of angiogenesis Inferred from direct assay Ref.1. Source: UniProtKB positive regulation of cytokine production involved in inflammatory response Inferred from electronic annotation. Source: Compara positive regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara proteoglycan metabolic process Inferred from direct assay Ref.6. Source: UniProtKB regulation of granulocyte macrophage colony-stimulating factor biosynthetic process Inferred from direct assay Ref.6. Source: UniProtKB regulation of interleukin-2 biosynthetic process Inferred from direct assay Ref.1. Source: UniProtKB regulation of interleukin-6 biosynthetic process Inferred from direct assay Ref.6. Source: UniProtKB regulation of interleukin-8 biosynthetic process Inferred from direct assay Ref.6. Source: UniProtKB regulation of transforming growth factor beta receptor signaling pathway Inferred from direct assay Ref.1. Source: UniProtKB
Cellular_component	extracellular region Non-traceable author statement Ref.6. Source: UniProtKB extracellular space Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	cytokine activity Inferred from direct assay Ref.1. Source: UniProtKB cytokine binding Inferred from direct assay Ref.6. Source: UniProtKB protein homodimerization activity Inferred from direct assay Ref.6. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 30

30

Ref.5

Chain

31 – 163

133

Interleukin-17F

PRO_0000015432

Amino acid modifications

Glycosylation

83

1

N-linked (GlcNAc...) Ref.7

Disulfide bond

47

Interchain (with C-137) Ref.7

Disulfide bond

102 ↔ 152

Ref.7

Disulfide bond

107 ↔ 154

Ref.7

Disulfide bond

137

Interchain (with C-47) Ref.7

Natural variations

Natural variant

95

1

S → L in CANDF6. Ref.8

VAR_065813

Natural variant

126

1

E → G.
Corresponds to variant rs2397084 [ dbSNP | Ensembl ].

VAR_058287

Natural variant

155

1

V → I.
Corresponds to variant rs11465553 [ dbSNP | Ensembl ].

VAR_058288

Natural variant

161

1

H → R. Ref.3
Corresponds to variant rs763780 [ dbSNP | Ensembl ].

VAR_058289

Secondary structure

1

.

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163

Helix Strand Turn

Details...

Helix

39 – 41

3

Beta strand

51 – 62

12

Turn

63 – 65

3

Helix

74 – 77

4

Beta strand

78 – 80

3

Beta strand

82 – 88

7

Beta strand

92 – 103

12

Beta strand

105 – 108

4

Beta strand

110 – 112

3

Beta strand

118 – 135

18

Helix

136 – 138

3

Beta strand

140 – 155

16

Beta strand

159 – 161

3

Sequences

	Sequence		Length	Mass (Da)
	Q96PD4 [UniParc]. Last modified June 16, 2009. Version 3. Checksum: E5287737C9E7BD46	FASTA	163	18,045
	10 20 30 40 50 60 MTVKTLHGPA MVKYLLLSIL GLAFLSEAAA RKIPKVGHTF FQKPESCPPV PGGSMKLDIG 70 80 90 100 110 120 IINENQRVSM SRNIESRSTS PWNYTVTWDP NRYPSEVVQA QCRNLGCINA QGKEDISMNS 130 140 150 160 VPIQQETLVV RRKHQGCSVS FQLEKVLVTV GCTCVTPVIH HVQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"IL-17F, a novel cytokine selectively expressed in activated T cells and monocytes, regulates angiogenesis and endothelial cell cytokine production." Starnes T., Robertson M.J., Sledge G., Kelich S., Nakshatri H., Broxmeyer H.E., Hromas R. J. Immunol. 167:4137-4140(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-161. Tissue: Blood.
[4]	"Identification of a novel cytokine, ML-1, and its expression in subjects with asthma." Kawaguchi M., Onuchic L.F., Li X.-D., Essayan D.M., Schroeder J., Xiao H.-Q., Liu M.C., Krishnaswamy G., Germino G., Huang S.-K. J. Immunol. 167:4430-4435(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 12-163.
[5]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 31-45.
[6]	"IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding." Hymowitz S.G., Filvaroff E.H., Yin J.P., Lee J., Cai L., Risser P., Maruoka M., Mao W., Foster J., Kelley R.F., Pan G., Gurney A.L., de Vos A.M., Starovasnik M.A. EMBO J. 20:5332-5341(2001) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.85 ANGSTROMS), CHARACTERIZATION.
[7]	"Structural basis of receptor sharing by interleukin 17 cytokines." Ely L.K., Fischer S., Garcia K.C. Nat. Immunol. 10:1245-1251(2009) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF 31-163 IN COMPLEX WITH IL17R, GLYCOSYLATION AT ASN-83, SUBUNIT, DISULFIDE BONDS.
[8]	"Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity." Puel A., Cypowyj S., Bustamante J., Wright J.F., Liu L., Lim H.K., Migaud M., Israel L., Chrabieh M., Audry M., Gumbleton M., Toulon A., Bodemer C., El-Baghdadi J., Whitters M., Paradis T., Brooks J., Collins M. , Wolfman N.M., Al-Muhsen S., Galicchio M., Abel L., Picard C., Casanova J.L. Science 332:65-68(2011) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT CANDF6 LEU-95.
+	Additional computationally mapped references.

Web resources

Wikipedia

Interleukin-17 entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF384857 mRNA. Translation: AAK83350.1.
AL034343 Genomic DNA. Translation: CAD92646.1. Sequence problems.
BC070124 mRNA. Translation: AAH70124.1.
AF332389 mRNA. Translation: AAL14427.1. Sequence problems.

IPI

IPI00791572.

RefSeq

NP_443104.1. NM_052872.3.

UniGene

Hs.272295.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1JPY	X-ray	2.85	A/B/X/Y	31-163	[»]
3JVF	X-ray	3.30	A/B	31-163	[»]

ProteinModelPortal

Q96PD4.

ModBase

Search...

Protein-protein interaction databases

STRING

9606.ENSP00000337432.

Polymorphism databases

DMDM

239938888.

Proteomic databases

PaxDb

Q96PD4.

PRIDE

Q96PD4.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000336123; ENSP00000337432; ENSG00000112116.

GeneID

112744.

KEGG

hsa:112744.

UCSC

uc003pal.1. human.

Organism-specific databases

CTD

112744.

GeneCards

GC06M052101.

HGNC

HGNC:16404. IL17F.

MIM

606496. gene.
613956. phenotype.

neXtProt

NX_Q96PD4.

Orphanet

1334. Chronic mucocutaneous candidiasis.

PharmGKB

PA29800.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG248962.

HOGENOM

HOG000064520.

HOVERGEN

HBG006143.

InParanoid

Q96PD4.

KO

K05494.

OMA

SSSPWDY.

OrthoDB

EOG4BG8XJ.

PhylomeDB

Q96PD4.

Enzyme and pathway databases

Pathway_Interaction_DB

il23pathway. IL23-mediated signaling events.

Gene expression databases

Bgee

Q96PD4.

CleanEx

HS_IL17F.
HS_IL24.

Genevestigator

Q96PD4.

GermOnline

ENSG00000112116. Homo sapiens.

Family and domain databases

InterPro

IPR010345. Interleukin-17.
IPR020440. Interleukin-17_chordata.
[Graphical view]

PANTHER

PTHR21295. PTHR21295. 1 hit.

Pfam

PF06083. IL17. 1 hit.
[Graphical view]

PRINTS

PR01932. INTRLEUKIN17.

ProtoNet

Search...

Other

EvolutionaryTrace

Q96PD4.

GenomeRNAi

112744.

NextBio

78647.

SOURCE

Search...

Entry information

Entry name

IL17F_HUMAN

Accession

Primary (citable) accession number: Q96PD4
Secondary accession number(s): Q6NSI0 , Q7Z6P4, Q96PI8, Q9NUE6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 31, 2002
Last sequence update:	June 16, 2009
Last modified:	May 1, 2013
This is version 104 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.