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Q96PD4

- IL17F_HUMAN

UniProt

Q96PD4 - IL17F_HUMAN

Protein

Interleukin-17F

Gene

IL17F

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Stimulates the production of other cytokines such as IL-6, IL-8 and granulocyte colony-stimulating factor, and can regulate cartilage matrix turnover. Stimulates PBMC and T-cell proliferation. Inhibits angiogenesis.

    GO - Molecular functioni

    1. cytokine activity Source: UniProtKB
    2. cytokine binding Source: UniProtKB
    3. protein homodimerization activity Source: UniProtKB

    GO - Biological processi

    1. cartilage development Source: UniProtKB
    2. cytokine biosynthetic process Source: UniProtKB
    3. inflammatory response Source: InterPro
    4. lymphotoxin A biosynthetic process Source: UniProtKB
    5. negative regulation of angiogenesis Source: UniProtKB
    6. positive regulation of cytokine production involved in inflammatory response Source: Ensembl
    7. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    8. proteoglycan metabolic process Source: UniProtKB
    9. regulation of granulocyte macrophage colony-stimulating factor biosynthetic process Source: UniProtKB
    10. regulation of interleukin-2 biosynthetic process Source: UniProtKB
    11. regulation of interleukin-6 biosynthetic process Source: UniProtKB
    12. regulation of interleukin-8 biosynthetic process Source: UniProtKB
    13. regulation of transforming growth factor beta receptor signaling pathway Source: UniProtKB

    Keywords - Molecular functioni

    Cytokine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-17F
    Short name:
    IL-17F
    Alternative name(s):
    Cytokine ML-1
    Gene namesi
    Name:IL17F
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:16404. IL17F.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB
    2. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Involvement in diseasei

    Candidiasis, familial, 6 (CANDF6) [MIM:613956]: A primary immunodeficiency disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti95 – 951S → L in CANDF6. 1 Publication
    VAR_065813

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    MIMi613956. phenotype.
    Orphaneti1334. Chronic mucocutaneous candidiasis.
    PharmGKBiPA29800.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 30301 PublicationAdd
    BLAST
    Chaini31 – 163133Interleukin-17FPRO_0000015432Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi47 – 47Interchain (with C-137)1 Publication
    Glycosylationi83 – 831N-linked (GlcNAc...)1 Publication
    Disulfide bondi102 ↔ 1521 Publication
    Disulfide bondi107 ↔ 1541 Publication
    Disulfide bondi137 – 137Interchain (with C-47)1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ96PD4.
    PRIDEiQ96PD4.

    Expressioni

    Tissue specificityi

    Expressed in activated, but not resting, CD4+ T-cells and activated monocytes.

    Gene expression databases

    BgeeiQ96PD4.
    CleanExiHS_IL17F.
    HS_IL24.
    GenevestigatoriQ96PD4.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked.1 Publication

    Protein-protein interaction databases

    STRINGi9606.ENSP00000337432.

    Structurei

    Secondary structure

    1
    163
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi39 – 413
    Beta strandi51 – 6212
    Turni63 – 653
    Helixi74 – 774
    Beta strandi78 – 803
    Beta strandi82 – 887
    Beta strandi92 – 10312
    Beta strandi105 – 1084
    Beta strandi110 – 1123
    Beta strandi118 – 13518
    Helixi136 – 1383
    Beta strandi140 – 15516
    Beta strandi159 – 1613

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1JPYX-ray2.85A/B/X/Y31-163[»]
    3JVFX-ray3.30A/B31-163[»]
    ProteinModelPortaliQ96PD4.
    SMRiQ96PD4. Positions 38-158.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ96PD4.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the IL-17 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG248962.
    HOGENOMiHOG000064520.
    HOVERGENiHBG006143.
    InParanoidiQ96PD4.
    KOiK05494.
    OMAiCPPLEDN.
    OrthoDBiEOG70089V.
    PhylomeDBiQ96PD4.
    TreeFamiTF314701.

    Family and domain databases

    Gene3Di2.10.90.10. 1 hit.
    InterProiIPR029034. Cystine-knot_cytokine.
    IPR020440. IL-17_chr.
    IPR010345. IL-17_fam.
    [Graphical view]
    PANTHERiPTHR21295. PTHR21295. 1 hit.
    PfamiPF06083. IL17. 1 hit.
    [Graphical view]
    PRINTSiPR01932. INTRLEUKIN17.
    SUPFAMiSSF57501. SSF57501. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q96PD4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTVKTLHGPA MVKYLLLSIL GLAFLSEAAA RKIPKVGHTF FQKPESCPPV    50
    PGGSMKLDIG IINENQRVSM SRNIESRSTS PWNYTVTWDP NRYPSEVVQA 100
    QCRNLGCINA QGKEDISMNS VPIQQETLVV RRKHQGCSVS FQLEKVLVTV 150
    GCTCVTPVIH HVQ 163
    Length:163
    Mass (Da):18,045
    Last modified:June 16, 2009 - v3
    Checksum:iE5287737C9E7BD46
    GO

    Sequence cautioni

    The sequence AAL14427.1 differs from that shown. Reason: Intron retention.
    The sequence CAD92646.1 differs from that shown. Reason: Erroneous gene model prediction.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti95 – 951S → L in CANDF6. 1 Publication
    VAR_065813
    Natural varianti126 – 1261E → G.
    Corresponds to variant rs2397084 [ dbSNP | Ensembl ].
    VAR_058287
    Natural varianti155 – 1551V → I.
    Corresponds to variant rs11465553 [ dbSNP | Ensembl ].
    VAR_058288
    Natural varianti161 – 1611H → R.1 Publication
    Corresponds to variant rs763780 [ dbSNP | Ensembl ].
    VAR_058289

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF384857 mRNA. Translation: AAK83350.1.
    AL034343 Genomic DNA. Translation: CAD92646.1. Sequence problems.
    BC070124 mRNA. Translation: AAH70124.1.
    AF332389 mRNA. Translation: AAL14427.1. Sequence problems.
    CCDSiCCDS4938.1.
    RefSeqiNP_443104.1. NM_052872.3.
    UniGeneiHs.272295.

    Genome annotation databases

    EnsembliENST00000336123; ENSP00000337432; ENSG00000112116.
    GeneIDi112744.
    KEGGihsa:112744.
    UCSCiuc003pal.1. human.

    Polymorphism databases

    DMDMi239938888.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Interleukin-17 entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF384857 mRNA. Translation: AAK83350.1 .
    AL034343 Genomic DNA. Translation: CAD92646.1 . Sequence problems.
    BC070124 mRNA. Translation: AAH70124.1 .
    AF332389 mRNA. Translation: AAL14427.1 . Sequence problems.
    CCDSi CCDS4938.1.
    RefSeqi NP_443104.1. NM_052872.3.
    UniGenei Hs.272295.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1JPY X-ray 2.85 A/B/X/Y 31-163 [» ]
    3JVF X-ray 3.30 A/B 31-163 [» ]
    ProteinModelPortali Q96PD4.
    SMRi Q96PD4. Positions 38-158.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000337432.

    Polymorphism databases

    DMDMi 239938888.

    Proteomic databases

    PaxDbi Q96PD4.
    PRIDEi Q96PD4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000336123 ; ENSP00000337432 ; ENSG00000112116 .
    GeneIDi 112744.
    KEGGi hsa:112744.
    UCSCi uc003pal.1. human.

    Organism-specific databases

    CTDi 112744.
    GeneCardsi GC06M052101.
    HGNCi HGNC:16404. IL17F.
    MIMi 606496. gene.
    613956. phenotype.
    neXtProti NX_Q96PD4.
    Orphaneti 1334. Chronic mucocutaneous candidiasis.
    PharmGKBi PA29800.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG248962.
    HOGENOMi HOG000064520.
    HOVERGENi HBG006143.
    InParanoidi Q96PD4.
    KOi K05494.
    OMAi CPPLEDN.
    OrthoDBi EOG70089V.
    PhylomeDBi Q96PD4.
    TreeFami TF314701.

    Miscellaneous databases

    EvolutionaryTracei Q96PD4.
    GenomeRNAii 112744.
    NextBioi 78647.
    PROi Q96PD4.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q96PD4.
    CleanExi HS_IL17F.
    HS_IL24.
    Genevestigatori Q96PD4.

    Family and domain databases

    Gene3Di 2.10.90.10. 1 hit.
    InterProi IPR029034. Cystine-knot_cytokine.
    IPR020440. IL-17_chr.
    IPR010345. IL-17_fam.
    [Graphical view ]
    PANTHERi PTHR21295. PTHR21295. 1 hit.
    Pfami PF06083. IL17. 1 hit.
    [Graphical view ]
    PRINTSi PR01932. INTRLEUKIN17.
    SUPFAMi SSF57501. SSF57501. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "IL-17F, a novel cytokine selectively expressed in activated T cells and monocytes, regulates angiogenesis and endothelial cell cytokine production."
      Starnes T., Robertson M.J., Sledge G., Kelich S., Nakshatri H., Broxmeyer H.E., Hromas R.
      J. Immunol. 167:4137-4140(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-161.
      Tissue: Blood.
    4. "Identification of a novel cytokine, ML-1, and its expression in subjects with asthma."
      Kawaguchi M., Onuchic L.F., Li X.-D., Essayan D.M., Schroeder J., Xiao H.-Q., Liu M.C., Krishnaswamy G., Germino G., Huang S.-K.
      J. Immunol. 167:4430-4435(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 12-163.
    5. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 31-45.
    6. "IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding."
      Hymowitz S.G., Filvaroff E.H., Yin J.P., Lee J., Cai L., Risser P., Maruoka M., Mao W., Foster J., Kelley R.F., Pan G., Gurney A.L., de Vos A.M., Starovasnik M.A.
      EMBO J. 20:5332-5341(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.85 ANGSTROMS), CHARACTERIZATION.
    7. "Structural basis of receptor sharing by interleukin 17 cytokines."
      Ely L.K., Fischer S., Garcia K.C.
      Nat. Immunol. 10:1245-1251(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF 31-163 IN COMPLEX WITH IL17R, GLYCOSYLATION AT ASN-83, SUBUNIT, DISULFIDE BONDS.
    8. Cited for: VARIANT CANDF6 LEU-95.

    Entry informationi

    Entry nameiIL17F_HUMAN
    AccessioniPrimary (citable) accession number: Q96PD4
    Secondary accession number(s): Q6NSI0
    , Q7Z6P4, Q96PI8, Q9NUE6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 31, 2002
    Last sequence update: June 16, 2009
    Last modified: October 1, 2014
    This is version 115 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3