Reviewed,
UniProtKB/Swiss-Prot Q96PD4 (IL17F_HUMAN)
Last modified
July 7, 2009.
Version 71.
History...
Clusters with 100%,
90%,
50% identity |
Documents (4) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Interleukin-17F Short name=IL-17F Alternative name(s): Interleukin-24 Short name=IL-24 Cytokine ML-1 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 163 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Stimulates the production of other cytokines such as IL-6, IL-8 and granulocyte colony-stimulating factor, and can regulate cartilage matrix turnover. Stimulates PBMC and T-cell proliferation. Inhibits angiogenesis. |
| Subunit structure | Homodimer; disulfide-linked. |
| Subcellular location | |
| Tissue specificity | Expressed in activated, but not resting, CD4+ T-cells and activated monocytes. |
| Sequence similarities | Belongs to the IL-17 family. |
Ontologies
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q96PD4-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q96PD4-2) The sequence of this isoform differs from the canonical sequence as follows: 1-10: Missing. | ||||||
| Note: No experimental confirmation available. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | |||||||||||||||||||||||||
Molecule processing | ||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 30 | 30 | ||||||||||||||||||||||||||||
| Chain | 31 – 163 | 133 | Interleukin-17F | PRO_0000015432 | ||||||||||||||||||||||||||
Amino acid modifications | ||||||||||||||||||||||||||||||
| Glycosylation | 83 | 1 | N-linked (GlcNAc...) | |||||||||||||||||||||||||||
| Disulfide bond | 47 | Interchain (with C-137) | ||||||||||||||||||||||||||||
| Disulfide bond | 102 ↔ 152 | |||||||||||||||||||||||||||||
| Disulfide bond | 107 ↔ 154 | |||||||||||||||||||||||||||||
| Disulfide bond | 137 | Interchain (with C-47) | ||||||||||||||||||||||||||||
Natural variations | ||||||||||||||||||||||||||||||
| Alternative sequence | 1 – 10 | 10 | Missing in isoform 2. | VSP_037500 | ||||||||||||||||||||||||||
Experimental info | ||||||||||||||||||||||||||||||
| Sequence conflict | 161 | 1 | H → R in AAH70124. Ref.3 | |||||||||||||||||||||||||||
Secondary structure | ||||||||||||||||||||||||||||||
Helix Strand Turn | ||||||||||||||||||||||||||||||
| Helix | 39 – 41 | 3 | ||||||||||||||||||||||||||||
| Beta strand | 51 – 62 | 12 | ||||||||||||||||||||||||||||
| Turn | 63 – 65 | 3 | ||||||||||||||||||||||||||||
| Helix | 74 – 77 | 4 | ||||||||||||||||||||||||||||
| Beta strand | 78 – 80 | 3 | ||||||||||||||||||||||||||||
| Beta strand | 82 – 88 | 7 | ||||||||||||||||||||||||||||
| Beta strand | 92 – 103 | 12 | ||||||||||||||||||||||||||||
| Beta strand | 105 – 108 | 4 | ||||||||||||||||||||||||||||
| Beta strand | 110 – 112 | 3 | ||||||||||||||||||||||||||||
| Beta strand | 118 – 135 | 18 | ||||||||||||||||||||||||||||
| Helix | 136 – 138 | 3 | ||||||||||||||||||||||||||||
| Beta strand | 140 – 155 | 16 | ||||||||||||||||||||||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "IL-17F, a novel cytokine selectively expressed in activated T cells and monocytes, regulates angiogenesis and endothelial cell cytokine production." Starnes T., Robertson M.J., Sledge G., Kelich S., Nakshatri H., Broxmeyer H.E., Hromas R. J. Immunol. 167:4137-4140(2001) [PubMed: 11591732] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). |
| [2] | "The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. Beck S.Nature 425:805-811(2003) [PubMed: 14574404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Blood. |
| [4] | "Identification of a novel cytokine, ML-1, and its expression in subjects with asthma." Kawaguchi M., Onuchic L.F., Li X.-D., Essayan D.M., Schroeder J., Xiao H.-Q., Liu M.C., Krishnaswamy G., Germino G., Huang S.-K. J. Immunol. 167:4430-4435(2001) [PubMed: 11591768] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-163 (ISOFORM 2). |
| [5] | "Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed: 15340161] [Abstract] Cited for: PROTEIN SEQUENCE OF 31-45. |
| [6] | "IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding." Hymowitz S.G., Filvaroff E.H., Yin J.P., Lee J., Cai L., Risser P., Maruoka M., Mao W., Foster J., Kelley R.F., Pan G., Gurney A.L., de Vos A.M., Starovasnik M.A. EMBO J. 20:5332-5341(2001) [PubMed: 11574464] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.85 ANGSTROMS), CHARACTERIZATION. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AF384857 mRNA. Translation: AAK83350.1. AL034343 Genomic DNA. Translation: CAD92646.1. BC070124 mRNA. Translation: AAH70124.1. AF332389 mRNA. Translation: AAL14427.1. Different initiation. | |||||||||||||
| IPI | IPI00791572. | ||||||||||||
| UniGene | Hs.272295 | ||||||||||||
3D structure databases | |||||||||||||
| |||||||||||||
| ModBase | Search... | ||||||||||||
Proteomic databases | |||||||||||||
| PRIDE | Q96PD4. | ||||||||||||
Genome annotation databases | |||||||||||||
| Ensembl | ENSG00000112116. Homo sapiens. [Contig view] | ||||||||||||
| UCSC | uc003pal.1. human. | ||||||||||||
Organism-specific databases | |||||||||||||
| GeneCards | GC06M052209. | ||||||||||||
| H-InvDB | HIX0032794. | ||||||||||||
| HGNC | HGNC:16404. IL17F. | ||||||||||||
| MIM | 606496. gene. | ||||||||||||
| PharmGKB | PA29800. | ||||||||||||
| GenAtlas | Search... | ||||||||||||
Phylogenomic databases | |||||||||||||
| HOVERGEN | Q96PD4. | ||||||||||||
Enzyme and pathway databases | |||||||||||||
| Pathway_Interaction_DB | il23pathway. IL23-mediated signaling events. | ||||||||||||
Gene expression databases | |||||||||||||
| ArrayExpress | Q96PD4. | ||||||||||||
| Bgee | Q96PD4. | ||||||||||||
| CleanEx | HS_IL17F. HS_IL24. | ||||||||||||
| GermOnline | ENSG00000112116. Homo sapiens. | ||||||||||||
Family and domain databases | |||||||||||||
| InterPro | IPR010345. IL17. [Graphical view] | ||||||||||||
| PANTHER | PTHR21295. IL17. 1 hit. | ||||||||||||
| Pfam | PF06083. IL17. 1 hit. [Graphical view] | ||||||||||||
| ProtoNet | Search... | ||||||||||||
Other Resources | |||||||||||||
| SOURCE | Search... | ||||||||||||
Entry information
| Entry name | IL17F_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q96PD4 Secondary accession number(s): Q6NSI0 Q9NUE6 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 6 Human chromosome 6: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with


