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Q96PD4

- IL17F_HUMAN

UniProt

Q96PD4 - IL17F_HUMAN

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Protein

Interleukin-17F

Gene

IL17F

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Stimulates the production of other cytokines such as IL-6, IL-8 and granulocyte colony-stimulating factor, and can regulate cartilage matrix turnover. Stimulates PBMC and T-cell proliferation. Inhibits angiogenesis.

GO - Molecular functioni

  1. cytokine activity Source: UniProtKB
  2. cytokine binding Source: UniProtKB
  3. protein homodimerization activity Source: UniProtKB

GO - Biological processi

  1. cartilage development Source: UniProtKB
  2. cytokine biosynthetic process Source: UniProtKB
  3. inflammatory response Source: InterPro
  4. lymphotoxin A biosynthetic process Source: UniProtKB
  5. negative regulation of angiogenesis Source: UniProtKB
  6. positive regulation of cytokine production involved in inflammatory response Source: Ensembl
  7. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  8. proteoglycan metabolic process Source: UniProtKB
  9. regulation of granulocyte macrophage colony-stimulating factor biosynthetic process Source: UniProtKB
  10. regulation of interleukin-2 biosynthetic process Source: UniProtKB
  11. regulation of interleukin-6 biosynthetic process Source: UniProtKB
  12. regulation of interleukin-8 biosynthetic process Source: UniProtKB
  13. regulation of transforming growth factor beta receptor signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-17F
Short name:
IL-17F
Alternative name(s):
Cytokine ML-1
Gene namesi
Name:IL17F
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:16404. IL17F.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB
  2. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Candidiasis, familial, 6 (CANDF6) [MIM:613956]: A primary immunodeficiency disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti95 – 951S → L in CANDF6. 1 Publication
VAR_065813

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi613956. phenotype.
Orphaneti1334. Chronic mucocutaneous candidosis.
PharmGKBiPA29800.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 30301 PublicationAdd
BLAST
Chaini31 – 163133Interleukin-17FPRO_0000015432Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi47 – 47Interchain (with C-137)1 Publication
Glycosylationi83 – 831N-linked (GlcNAc...)1 Publication
Disulfide bondi102 ↔ 1521 Publication
Disulfide bondi107 ↔ 1541 Publication
Disulfide bondi137 – 137Interchain (with C-47)1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ96PD4.
PRIDEiQ96PD4.

Expressioni

Tissue specificityi

Expressed in activated, but not resting, CD4+ T-cells and activated monocytes.

Gene expression databases

BgeeiQ96PD4.
CleanExiHS_IL17F.
HS_IL24.
GenevestigatoriQ96PD4.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.1 Publication

Protein-protein interaction databases

STRINGi9606.ENSP00000337432.

Structurei

Secondary structure

1
163
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi39 – 413Combined sources
Beta strandi51 – 6212Combined sources
Turni63 – 653Combined sources
Helixi74 – 774Combined sources
Beta strandi78 – 803Combined sources
Beta strandi82 – 887Combined sources
Beta strandi92 – 10312Combined sources
Beta strandi105 – 1084Combined sources
Beta strandi110 – 1123Combined sources
Beta strandi118 – 13518Combined sources
Helixi136 – 1383Combined sources
Beta strandi140 – 15516Combined sources
Beta strandi159 – 1613Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1JPYX-ray2.85A/B/X/Y31-163[»]
3JVFX-ray3.30A/B31-163[»]
ProteinModelPortaliQ96PD4.
SMRiQ96PD4. Positions 38-158.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96PD4.

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-17 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG248962.
GeneTreeiENSGT00730000110824.
HOGENOMiHOG000064520.
HOVERGENiHBG006143.
InParanoidiQ96PD4.
KOiK05494.
OMAiCPPLEDN.
OrthoDBiEOG70089V.
PhylomeDBiQ96PD4.
TreeFamiTF314701.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR020440. IL-17_chr.
IPR010345. IL-17_fam.
[Graphical view]
PANTHERiPTHR21295. PTHR21295. 1 hit.
PfamiPF06083. IL17. 1 hit.
[Graphical view]
PRINTSiPR01932. INTRLEUKIN17.
SUPFAMiSSF57501. SSF57501. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96PD4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTVKTLHGPA MVKYLLLSIL GLAFLSEAAA RKIPKVGHTF FQKPESCPPV
60 70 80 90 100
PGGSMKLDIG IINENQRVSM SRNIESRSTS PWNYTVTWDP NRYPSEVVQA
110 120 130 140 150
QCRNLGCINA QGKEDISMNS VPIQQETLVV RRKHQGCSVS FQLEKVLVTV
160
GCTCVTPVIH HVQ
Length:163
Mass (Da):18,045
Last modified:June 16, 2009 - v3
Checksum:iE5287737C9E7BD46
GO

Sequence cautioni

The sequence AAL14427.1 differs from that shown. Reason: Intron retention.Curated
The sequence CAD92646.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti95 – 951S → L in CANDF6. 1 Publication
VAR_065813
Natural varianti126 – 1261E → G.
Corresponds to variant rs2397084 [ dbSNP | Ensembl ].
VAR_058287
Natural varianti155 – 1551V → I.
Corresponds to variant rs11465553 [ dbSNP | Ensembl ].
VAR_058288
Natural varianti161 – 1611H → R.1 Publication
Corresponds to variant rs763780 [ dbSNP | Ensembl ].
VAR_058289

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF384857 mRNA. Translation: AAK83350.1.
AL034343 Genomic DNA. Translation: CAD92646.1. Sequence problems.
BC070124 mRNA. Translation: AAH70124.1.
AF332389 mRNA. Translation: AAL14427.1. Sequence problems.
CCDSiCCDS4938.1.
RefSeqiNP_443104.1. NM_052872.3.
UniGeneiHs.272295.

Genome annotation databases

EnsembliENST00000336123; ENSP00000337432; ENSG00000112116.
GeneIDi112744.
KEGGihsa:112744.
UCSCiuc003pal.1. human.

Polymorphism databases

DMDMi239938888.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Interleukin-17 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF384857 mRNA. Translation: AAK83350.1 .
AL034343 Genomic DNA. Translation: CAD92646.1 . Sequence problems.
BC070124 mRNA. Translation: AAH70124.1 .
AF332389 mRNA. Translation: AAL14427.1 . Sequence problems.
CCDSi CCDS4938.1.
RefSeqi NP_443104.1. NM_052872.3.
UniGenei Hs.272295.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1JPY X-ray 2.85 A/B/X/Y 31-163 [» ]
3JVF X-ray 3.30 A/B 31-163 [» ]
ProteinModelPortali Q96PD4.
SMRi Q96PD4. Positions 38-158.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000337432.

Polymorphism databases

DMDMi 239938888.

Proteomic databases

PaxDbi Q96PD4.
PRIDEi Q96PD4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000336123 ; ENSP00000337432 ; ENSG00000112116 .
GeneIDi 112744.
KEGGi hsa:112744.
UCSCi uc003pal.1. human.

Organism-specific databases

CTDi 112744.
GeneCardsi GC06M052101.
HGNCi HGNC:16404. IL17F.
MIMi 606496. gene.
613956. phenotype.
neXtProti NX_Q96PD4.
Orphaneti 1334. Chronic mucocutaneous candidosis.
PharmGKBi PA29800.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG248962.
GeneTreei ENSGT00730000110824.
HOGENOMi HOG000064520.
HOVERGENi HBG006143.
InParanoidi Q96PD4.
KOi K05494.
OMAi CPPLEDN.
OrthoDBi EOG70089V.
PhylomeDBi Q96PD4.
TreeFami TF314701.

Miscellaneous databases

EvolutionaryTracei Q96PD4.
GenomeRNAii 112744.
NextBioi 78647.
PROi Q96PD4.
SOURCEi Search...

Gene expression databases

Bgeei Q96PD4.
CleanExi HS_IL17F.
HS_IL24.
Genevestigatori Q96PD4.

Family and domain databases

Gene3Di 2.10.90.10. 1 hit.
InterProi IPR029034. Cystine-knot_cytokine.
IPR020440. IL-17_chr.
IPR010345. IL-17_fam.
[Graphical view ]
PANTHERi PTHR21295. PTHR21295. 1 hit.
Pfami PF06083. IL17. 1 hit.
[Graphical view ]
PRINTSi PR01932. INTRLEUKIN17.
SUPFAMi SSF57501. SSF57501. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "IL-17F, a novel cytokine selectively expressed in activated T cells and monocytes, regulates angiogenesis and endothelial cell cytokine production."
    Starnes T., Robertson M.J., Sledge G., Kelich S., Nakshatri H., Broxmeyer H.E., Hromas R.
    J. Immunol. 167:4137-4140(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-161.
    Tissue: Blood.
  4. "Identification of a novel cytokine, ML-1, and its expression in subjects with asthma."
    Kawaguchi M., Onuchic L.F., Li X.-D., Essayan D.M., Schroeder J., Xiao H.-Q., Liu M.C., Krishnaswamy G., Germino G., Huang S.-K.
    J. Immunol. 167:4430-4435(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 12-163.
  5. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 31-45.
  6. "IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding."
    Hymowitz S.G., Filvaroff E.H., Yin J.P., Lee J., Cai L., Risser P., Maruoka M., Mao W., Foster J., Kelley R.F., Pan G., Gurney A.L., de Vos A.M., Starovasnik M.A.
    EMBO J. 20:5332-5341(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.85 ANGSTROMS), CHARACTERIZATION.
  7. "Structural basis of receptor sharing by interleukin 17 cytokines."
    Ely L.K., Fischer S., Garcia K.C.
    Nat. Immunol. 10:1245-1251(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF 31-163 IN COMPLEX WITH IL17R, GLYCOSYLATION AT ASN-83, SUBUNIT, DISULFIDE BONDS.
  8. Cited for: VARIANT CANDF6 LEU-95.

Entry informationi

Entry nameiIL17F_HUMAN
AccessioniPrimary (citable) accession number: Q96PD4
Secondary accession number(s): Q6NSI0
, Q7Z6P4, Q96PI8, Q9NUE6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: June 16, 2009
Last modified: November 26, 2014
This is version 117 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3