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Protein

Discoidin, CUB and LCCL domain-containing protein 2

Gene

DCBLD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • intracellular receptor signaling pathway Source: UniProtKB
  • negative regulation of cell growth Source: UniProtKB
  • wound healing Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Discoidin, CUB and LCCL domain-containing protein 2
Alternative name(s):
CUB, LCCL and coagulation factor V/VIII-homology domains protein 1
Endothelial and smooth muscle cell-derived neuropilin-like protein
Gene namesi
Name:DCBLD2
Synonyms:CLCP1, ESDN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:24627. DCBLD2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini67 – 528ExtracellularSequence analysisAdd BLAST462
Transmembranei529 – 549HelicalSequence analysisAdd BLAST21
Topological domaini550 – 775CytoplasmicSequence analysisAdd BLAST226

GO - Cellular componenti

  • cell surface Source: UniProtKB
  • integral component of plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi131566.
OpenTargetsiENSG00000057019.
PharmGKBiPA134869307.

Polymorphism and mutation databases

BioMutaiDCBLD2.
DMDMi57013820.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 66Sequence analysisAdd BLAST66
ChainiPRO_000002107867 – 775Discoidin, CUB and LCCL domain-containing protein 2Add BLAST709

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi72 ↔ 99By similarity
Glycosylationi95N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi126 ↔ 148By similarity
Glycosylationi155N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi215 ↔ 237By similarity
Glycosylationi272N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi292 ↔ 449By similarity
Glycosylationi474N-linked (GlcNAc...)Sequence analysis1
Glycosylationi516N-linked (GlcNAc...)Sequence analysis1
Glycosylationi522N-linked (GlcNAc...)Sequence analysis1
Modified residuei606PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ96PD2.
MaxQBiQ96PD2.
PaxDbiQ96PD2.
PeptideAtlasiQ96PD2.
PRIDEiQ96PD2.

PTM databases

iPTMnetiQ96PD2.
PhosphoSitePlusiQ96PD2.
SwissPalmiQ96PD2.

Expressioni

Tissue specificityi

Highly expressed in testis, heart, skeletal muscle and also in cultured vascular smooth muscle cells.2 Publications

Inductioni

Increased in lung cancers during the process of tumor progression.

Gene expression databases

BgeeiENSG00000057019.
CleanExiHS_DCBLD2.
ExpressionAtlasiQ96PD2. baseline and differential.
GenevisibleiQ96PD2. HS.

Organism-specific databases

HPAiHPA016909.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CRKLP461093EBI-8536103,EBI-910

Protein-protein interaction databases

BioGridi126285. 12 interactors.
IntActiQ96PD2. 3 interactors.
STRINGi9606.ENSP00000321573.

Structurei

3D structure databases

ProteinModelPortaliQ96PD2.
SMRiQ96PD2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini72 – 186CUBPROSITE-ProRule annotationAdd BLAST115
Domaini187 – 285LCCLPROSITE-ProRule annotationAdd BLAST99
Domaini292 – 449F5/8 type CPROSITE-ProRule annotationAdd BLAST158

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi463 – 466Poly-Pro4

Sequence similaritiesi

Contains 1 CUB domain.PROSITE-ProRule annotation
Contains 1 F5/8 type C domain.PROSITE-ProRule annotation
Contains 1 LCCL domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II5Z. Eukaryota.
ENOG4110JCT. LUCA.
GeneTreeiENSGT00760000119073.
HOGENOMiHOG000000681.
HOVERGENiHBG106294.
InParanoidiQ96PD2.
OMAiLEWTDHT.
OrthoDBiEOG091G02UL.
PhylomeDBiQ96PD2.
TreeFamiTF352191.

Family and domain databases

CDDicd00041. CUB. 1 hit.
Gene3Di2.170.130.20. 1 hit.
2.60.120.260. 1 hit.
2.60.120.290. 1 hit.
InterProiIPR000859. CUB_dom.
IPR000421. FA58C.
IPR008979. Galactose-bd-like.
IPR004043. LCCL.
[Graphical view]
PfamiPF00431. CUB. 1 hit.
PF00754. F5_F8_type_C. 1 hit.
PF03815. LCCL. 1 hit.
[Graphical view]
SMARTiSM00042. CUB. 1 hit.
SM00231. FA58C. 1 hit.
SM00603. LCCL. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF49854. SSF49854. 1 hit.
SSF69848. SSF69848. 1 hit.
PROSITEiPS01180. CUB. 1 hit.
PS01285. FA58C_1. 1 hit.
PS50022. FA58C_3. 1 hit.
PS50820. LCCL. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96PD2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASRAVVRAR RCPQCPQVRA AAAAPAWAAL PLSRSLPPCS NSSSFSMPLF
60 70 80 90 100
LLLLLVLLLL LEDAGAQQGD GCGHTVLGPE SGTLTSINYP QTYPNSTVCE
110 120 130 140 150
WEIRVKMGER VRIKFGDFDI EDSDSCHFNY LRIYNGIGVS RTEIGKYCGL
160 170 180 190 200
GLQMNHSIES KGNEITLLFM SGIHVSGRGF LASYSVIDKQ DLITCLDTAS
210 220 230 240 250
NFLEPEFSKY CPAGCLLPFA EISGTIPHGY RDSSPLCMAG VHAGVVSNTL
260 270 280 290 300
GGQISVVISK GIPYYESSLA NNVTSVVGHL STSLFTFKTS GCYGTLGMES
310 320 330 340 350
GVIADPQITA SSVLEWTDHT GQENSWKPKK ARLKKPGPPW AAFATDEYQW
360 370 380 390 400
LQIDLNKEKK ITGIITTGST MVEHNYYVSA YRILYSDDGQ KWTVYREPGV
410 420 430 440 450
EQDKIFQGNK DYHQDVRNNF LPPIIARFIR VNPTQWQQKI AMKMELLGCQ
460 470 480 490 500
FIPKGRPPKL TQPPPPRNSN DLKNTTAPPK IAKGRAPKFT QPLQPRSSNE
510 520 530 540 550
FPAQTEQTTA SPDIRNTTVT PNVTKDVALA AVLVPVLVMV LTTLILILVC
560 570 580 590 600
AWHWRNRKKK TEGTYDLPYW DRAGWWKGMK QFLPAKAVDH EETPVRYSSS
610 620 630 640 650
EVNHLSPREV TTVLQADSAE YAQPLVGGIV GTLHQRSTFK PEEGKEAGYA
660 670 680 690 700
DLDPYNSPGQ EVYHAYAEPL PITGPEYATP IIMDMSGHPT TSVGQPSTST
710 720 730 740 750
FKATGNQPPP LVGTYNTLLS RTDSCSSAQA QYDTPKAGKP GLPAPDELVY
760 770
QVPQSTQEVS GAGRDGECDV FKEIL
Length:775
Mass (Da):85,035
Last modified:December 1, 2001 - v1
Checksum:i3D06F81EF2337010
GO
Isoform 2 (identifier: Q96PD2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     574-574: G → GFYLMVSLACRHNEG

Note: No experimental confirmation available.
Show »
Length:789
Mass (Da):86,657
Checksum:iD22BB46FD86DD55E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050944144I → M.Corresponds to variant rs9838238dbSNPEnsembl.1
Natural variantiVAR_050945723D → N.Corresponds to variant rs16840208dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_010715574G → GFYLMVSLACRHNEG in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF387547 mRNA. Translation: AAL30178.1.
AB073146 mRNA. Translation: BAB91138.1.
AC106728 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79845.1.
CH471052 Genomic DNA. Translation: EAW79847.1.
BC029658 mRNA. Translation: AAH29658.1.
CCDSiCCDS46878.1. [Q96PD2-1]
RefSeqiNP_563615.3. NM_080927.3. [Q96PD2-1]
UniGeneiHs.203691.

Genome annotation databases

EnsembliENST00000326840; ENSP00000321573; ENSG00000057019. [Q96PD2-1]
ENST00000326857; ENSP00000321646; ENSG00000057019. [Q96PD2-2]
GeneIDi131566.
KEGGihsa:131566.
UCSCiuc003dtd.4. human. [Q96PD2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF387547 mRNA. Translation: AAL30178.1.
AB073146 mRNA. Translation: BAB91138.1.
AC106728 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79845.1.
CH471052 Genomic DNA. Translation: EAW79847.1.
BC029658 mRNA. Translation: AAH29658.1.
CCDSiCCDS46878.1. [Q96PD2-1]
RefSeqiNP_563615.3. NM_080927.3. [Q96PD2-1]
UniGeneiHs.203691.

3D structure databases

ProteinModelPortaliQ96PD2.
SMRiQ96PD2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126285. 12 interactors.
IntActiQ96PD2. 3 interactors.
STRINGi9606.ENSP00000321573.

PTM databases

iPTMnetiQ96PD2.
PhosphoSitePlusiQ96PD2.
SwissPalmiQ96PD2.

Polymorphism and mutation databases

BioMutaiDCBLD2.
DMDMi57013820.

Proteomic databases

EPDiQ96PD2.
MaxQBiQ96PD2.
PaxDbiQ96PD2.
PeptideAtlasiQ96PD2.
PRIDEiQ96PD2.

Protocols and materials databases

DNASUi131566.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000326840; ENSP00000321573; ENSG00000057019. [Q96PD2-1]
ENST00000326857; ENSP00000321646; ENSG00000057019. [Q96PD2-2]
GeneIDi131566.
KEGGihsa:131566.
UCSCiuc003dtd.4. human. [Q96PD2-1]

Organism-specific databases

CTDi131566.
DisGeNETi131566.
GeneCardsiDCBLD2.
HGNCiHGNC:24627. DCBLD2.
HPAiHPA016909.
MIMi608698. gene.
neXtProtiNX_Q96PD2.
OpenTargetsiENSG00000057019.
PharmGKBiPA134869307.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410II5Z. Eukaryota.
ENOG4110JCT. LUCA.
GeneTreeiENSGT00760000119073.
HOGENOMiHOG000000681.
HOVERGENiHBG106294.
InParanoidiQ96PD2.
OMAiLEWTDHT.
OrthoDBiEOG091G02UL.
PhylomeDBiQ96PD2.
TreeFamiTF352191.

Miscellaneous databases

ChiTaRSiDCBLD2. human.
GeneWikiiDCBLD2.
GenomeRNAii131566.
PROiQ96PD2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000057019.
CleanExiHS_DCBLD2.
ExpressionAtlasiQ96PD2. baseline and differential.
GenevisibleiQ96PD2. HS.

Family and domain databases

CDDicd00041. CUB. 1 hit.
Gene3Di2.170.130.20. 1 hit.
2.60.120.260. 1 hit.
2.60.120.290. 1 hit.
InterProiIPR000859. CUB_dom.
IPR000421. FA58C.
IPR008979. Galactose-bd-like.
IPR004043. LCCL.
[Graphical view]
PfamiPF00431. CUB. 1 hit.
PF00754. F5_F8_type_C. 1 hit.
PF03815. LCCL. 1 hit.
[Graphical view]
SMARTiSM00042. CUB. 1 hit.
SM00231. FA58C. 1 hit.
SM00603. LCCL. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF49854. SSF49854. 1 hit.
SSF69848. SSF69848. 1 hit.
PROSITEiPS01180. CUB. 1 hit.
PS01285. FA58C_1. 1 hit.
PS50022. FA58C_3. 1 hit.
PS50820. LCCL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDCBD2_HUMAN
AccessioniPrimary (citable) accession number: Q96PD2
Secondary accession number(s): B7WNL1
, D3DN41, Q8N6M4, Q8TDX2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.