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Q96PC2 (IP6K3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Inositol hexakisphosphate kinase 3

Short name=InsP6 kinase 3
EC=2.7.4.21
Alternative name(s):
Inositol hexaphosphate kinase 3
Gene names
Name:IP6K3
Synonyms:IHPK3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length410 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. Ref.1

Catalytic activity

ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate.

ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.

Subcellular location

Cytoplasm Ref.1.

Tissue specificity

Detected in brain.

Sequence similarities

Belongs to the inositol phosphokinase (IPK) family.

Sequence caution

The sequence BAB71225.2 differs from that shown. Reason: Frameshift at position 122.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 410410Inositol hexakisphosphate kinase 3
PRO_0000066881

Regions

Region211 – 2199Substrate binding By similarity

Natural variations

Natural variant601R → W.
Corresponds to variant rs34431226 [ dbSNP | Ensembl ].
VAR_031590
Natural variant3081A → V.
Corresponds to variant rs34573836 [ dbSNP | Ensembl ].
VAR_031591
Natural variant3121V → I. Ref.2
Corresponds to variant rs4713668 [ dbSNP | Ensembl ].
VAR_031592
Natural variant3781Y → S.
Corresponds to variant rs34343647 [ dbSNP | Ensembl ].
VAR_031593

Experimental info

Mutagenesis2171K → A: Loss of activity. Ref.1
Mutagenesis3251S → A: Strongly reduces activity. Ref.1
Sequence conflict561L → Q in AAL17053. Ref.1
Sequence conflict3041H → L in BAB71225. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q96PC2 [UniParc].

Last modified April 3, 2007. Version 2.
Checksum: CA61C7D4FA70F7F3

FASTA41046,417
        10         20         30         40         50         60 
MVVQNSADAG DMRAGVQLEP FLHQVGGHMS VMKYDEHTVC KPLVSREQRF YESLPLAMKR 

        70         80         90        100        110        120 
FTPQYKGTVT VHLWKDSTGH LSLVANPVKE SQEPFKVSTE SAAVAIWQTL QQTTGSNGSD 

       130        140        150        160        170        180 
CTLAQWPHAQ LARSPKESPA KALLRSEPHL NTPAFSLVED TNGNQVERKS FNPWGLQCHQ 

       190        200        210        220        230        240 
AHLTRLCSEY PENKRHRFLL LENVVSQYTH PCVLDLKMGT RQHGDDASEE KKARHMRKCA 

       250        260        270        280        290        300 
QSTSACLGVR ICGMQVYQTD KKYFLCKDKY YGRKLSVEGF RQALYQFLHN GSHLRRELLE 

       310        320        330        340        350        360 
PILHQLRALL SVIRSQSSYR FYSSSLLVIY DGQEPPERAP GSPHPHEAPQ AAHGSSPGGL 

       370        380        390        400        410 
TKVDIRMIDF AHTTYKGYWN EHTTYDGPDP GYIFGLENLI RILQDIQEGE 

« Hide

References

« Hide 'large scale' references
[1]"Identification and characterization of a novel inositol hexakisphosphate kinase."
Saiardi A., Nagata E., Luo H.R., Snowman A.M., Snyder S.H.
J. Biol. Chem. 276:39179-39185(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], MUTAGENESIS OF LYS-217 AND SER-325, FUNCTION, SUBCELLULAR LOCATION.
Tissue: Brain.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ILE-312.
Tissue: Tongue.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF393812 mRNA. Translation: AAL17053.1.
AK056586 mRNA. Translation: BAB71225.2. Frameshift.
RefSeqNP_001136355.1. NM_001142883.1.
NP_473452.2. NM_054111.4.
XP_005248899.1. XM_005248842.1.
UniGeneHs.17253.

3D structure databases

ProteinModelPortalQ96PC2.
SMRQ96PC2. Positions 188-407.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000293756.

PTM databases

PhosphoSiteQ96PC2.

Polymorphism databases

DMDM143811404.

Proteomic databases

PaxDbQ96PC2.
PRIDEQ96PC2.

Protocols and materials databases

DNASU117283.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000293756; ENSP00000293756; ENSG00000161896.
ENST00000451316; ENSP00000398861; ENSG00000161896.
GeneID117283.
KEGGhsa:117283.
UCSCuc003ofb.2. human.

Organism-specific databases

CTD117283.
GeneCardsGC06M033689.
HGNCHGNC:17269. IP6K3.
HPAHPA053644.
MIM606993. gene.
neXtProtNX_Q96PC2.
PharmGKBPA164721016.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG274869.
HOGENOMHOG000007418.
HOVERGENHBG052140.
InParanoidQ96PC2.
KOK07756.
OMAEHTTYDG.
OrthoDBEOG747PHX.
PhylomeDBQ96PC2.
TreeFamTF314066.

Enzyme and pathway databases

BioCycMetaCyc:HS08619-MONOMER.
ReactomeREACT_111217. Metabolism.

Gene expression databases

BgeeQ96PC2.
CleanExHS_IP6K3.
GenevestigatorQ96PC2.

Family and domain databases

InterProIPR005522. IPK.
[Graphical view]
PANTHERPTHR12400. PTHR12400. 1 hit.
PfamPF03770. IPK. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi117283.
NextBio80186.
PROQ96PC2.
SOURCESearch...

Entry information

Entry nameIP6K3_HUMAN
AccessionPrimary (citable) accession number: Q96PC2
Secondary accession number(s): Q96MQ9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: April 3, 2007
Last modified: April 16, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM