Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q96PC2

- IP6K3_HUMAN

UniProt

Q96PC2 - IP6K3_HUMAN

Protein

Inositol hexakisphosphate kinase 3

Gene

IP6K3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 2 (03 Apr 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4.1 Publication

    Catalytic activityi

    ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate.
    ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. inositol-1,4,5-trisphosphate 3-kinase activity Source: InterPro
    3. inositol hexakisphosphate 1-kinase activity Source: UniProtKB-EC
    4. inositol hexakisphosphate 3-kinase activity Source: UniProtKB-EC
    5. inositol hexakisphosphate 5-kinase activity Source: UniProtKB-EC
    6. inositol hexakisphosphate 6-kinase activity Source: MGI

    GO - Biological processi

    1. inositol phosphate biosynthetic process Source: MGI
    2. inositol phosphate metabolic process Source: Reactome
    3. phosphatidylinositol metabolic process Source: UniProtKB
    4. protein phosphorylation Source: UniProtKB
    5. small molecule metabolic process Source: Reactome

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMetaCyc:HS08619-MONOMER.
    ReactomeiREACT_150188. Synthesis of pyrophosphates in the cytosol.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inositol hexakisphosphate kinase 3 (EC:2.7.4.21)
    Short name:
    InsP6 kinase 3
    Alternative name(s):
    Inositol hexaphosphate kinase 3
    Gene namesi
    Name:IP6K3
    Synonyms:IHPK3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:17269. IP6K3.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. cytosol Source: Reactome
    3. nucleus Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi217 – 2171K → A: Loss of activity. 1 Publication
    Mutagenesisi325 – 3251S → A: Strongly reduces activity. 1 Publication

    Organism-specific databases

    PharmGKBiPA164721016.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 410410Inositol hexakisphosphate kinase 3PRO_0000066881Add
    BLAST

    Proteomic databases

    PaxDbiQ96PC2.
    PRIDEiQ96PC2.

    PTM databases

    PhosphoSiteiQ96PC2.

    Expressioni

    Tissue specificityi

    Detected in brain.

    Gene expression databases

    BgeeiQ96PC2.
    CleanExiHS_IP6K3.
    GenevestigatoriQ96PC2.

    Organism-specific databases

    HPAiHPA053644.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000293756.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96PC2.
    SMRiQ96PC2. Positions 188-408.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni211 – 2199Substrate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG274869.
    HOGENOMiHOG000007418.
    HOVERGENiHBG052140.
    InParanoidiQ96PC2.
    KOiK07756.
    OMAiEHTTYDG.
    OrthoDBiEOG747PHX.
    PhylomeDBiQ96PC2.
    TreeFamiTF314066.

    Family and domain databases

    InterProiIPR005522. IPK.
    [Graphical view]
    PANTHERiPTHR12400. PTHR12400. 1 hit.
    PfamiPF03770. IPK. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96PC2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVVQNSADAG DMRAGVQLEP FLHQVGGHMS VMKYDEHTVC KPLVSREQRF    50
    YESLPLAMKR FTPQYKGTVT VHLWKDSTGH LSLVANPVKE SQEPFKVSTE 100
    SAAVAIWQTL QQTTGSNGSD CTLAQWPHAQ LARSPKESPA KALLRSEPHL 150
    NTPAFSLVED TNGNQVERKS FNPWGLQCHQ AHLTRLCSEY PENKRHRFLL 200
    LENVVSQYTH PCVLDLKMGT RQHGDDASEE KKARHMRKCA QSTSACLGVR 250
    ICGMQVYQTD KKYFLCKDKY YGRKLSVEGF RQALYQFLHN GSHLRRELLE 300
    PILHQLRALL SVIRSQSSYR FYSSSLLVIY DGQEPPERAP GSPHPHEAPQ 350
    AAHGSSPGGL TKVDIRMIDF AHTTYKGYWN EHTTYDGPDP GYIFGLENLI 400
    RILQDIQEGE 410
    Length:410
    Mass (Da):46,417
    Last modified:April 3, 2007 - v2
    Checksum:iCA61C7D4FA70F7F3
    GO

    Sequence cautioni

    The sequence BAB71225.2 differs from that shown. Reason: Frameshift at position 122.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti56 – 561L → Q in AAL17053. (PubMed:11502751)Curated
    Sequence conflicti304 – 3041H → L in BAB71225. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti60 – 601R → W.
    Corresponds to variant rs34431226 [ dbSNP | Ensembl ].
    VAR_031590
    Natural varianti308 – 3081A → V.
    Corresponds to variant rs34573836 [ dbSNP | Ensembl ].
    VAR_031591
    Natural varianti312 – 3121V → I.1 Publication
    Corresponds to variant rs4713668 [ dbSNP | Ensembl ].
    VAR_031592
    Natural varianti378 – 3781Y → S.
    Corresponds to variant rs34343647 [ dbSNP | Ensembl ].
    VAR_031593

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF393812 mRNA. Translation: AAL17053.1.
    AK056586 mRNA. Translation: BAB71225.2. Frameshift.
    CCDSiCCDS34435.1.
    RefSeqiNP_001136355.1. NM_001142883.1.
    NP_473452.2. NM_054111.4.
    XP_005248899.1. XM_005248842.1.
    UniGeneiHs.17253.

    Genome annotation databases

    EnsembliENST00000293756; ENSP00000293756; ENSG00000161896.
    ENST00000451316; ENSP00000398861; ENSG00000161896.
    GeneIDi117283.
    KEGGihsa:117283.
    UCSCiuc003ofb.2. human.

    Polymorphism databases

    DMDMi143811404.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF393812 mRNA. Translation: AAL17053.1 .
    AK056586 mRNA. Translation: BAB71225.2 . Frameshift.
    CCDSi CCDS34435.1.
    RefSeqi NP_001136355.1. NM_001142883.1.
    NP_473452.2. NM_054111.4.
    XP_005248899.1. XM_005248842.1.
    UniGenei Hs.17253.

    3D structure databases

    ProteinModelPortali Q96PC2.
    SMRi Q96PC2. Positions 188-408.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000293756.

    PTM databases

    PhosphoSitei Q96PC2.

    Polymorphism databases

    DMDMi 143811404.

    Proteomic databases

    PaxDbi Q96PC2.
    PRIDEi Q96PC2.

    Protocols and materials databases

    DNASUi 117283.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000293756 ; ENSP00000293756 ; ENSG00000161896 .
    ENST00000451316 ; ENSP00000398861 ; ENSG00000161896 .
    GeneIDi 117283.
    KEGGi hsa:117283.
    UCSCi uc003ofb.2. human.

    Organism-specific databases

    CTDi 117283.
    GeneCardsi GC06M033689.
    HGNCi HGNC:17269. IP6K3.
    HPAi HPA053644.
    MIMi 606993. gene.
    neXtProti NX_Q96PC2.
    PharmGKBi PA164721016.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG274869.
    HOGENOMi HOG000007418.
    HOVERGENi HBG052140.
    InParanoidi Q96PC2.
    KOi K07756.
    OMAi EHTTYDG.
    OrthoDBi EOG747PHX.
    PhylomeDBi Q96PC2.
    TreeFami TF314066.

    Enzyme and pathway databases

    BioCyci MetaCyc:HS08619-MONOMER.
    Reactomei REACT_150188. Synthesis of pyrophosphates in the cytosol.

    Miscellaneous databases

    GenomeRNAii 117283.
    NextBioi 80186.
    PROi Q96PC2.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q96PC2.
    CleanExi HS_IP6K3.
    Genevestigatori Q96PC2.

    Family and domain databases

    InterProi IPR005522. IPK.
    [Graphical view ]
    PANTHERi PTHR12400. PTHR12400. 1 hit.
    Pfami PF03770. IPK. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of a novel inositol hexakisphosphate kinase."
      Saiardi A., Nagata E., Luo H.R., Snowman A.M., Snyder S.H.
      J. Biol. Chem. 276:39179-39185(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], MUTAGENESIS OF LYS-217 AND SER-325, FUNCTION, SUBCELLULAR LOCATION.
      Tissue: Brain.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ILE-312.
      Tissue: Tongue.

    Entry informationi

    Entry nameiIP6K3_HUMAN
    AccessioniPrimary (citable) accession number: Q96PC2
    Secondary accession number(s): Q96MQ9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: April 3, 2007
    Last modified: October 1, 2014
    This is version 111 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3