Q96PC2 (IP6K3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Inositol hexakisphosphate kinase 3
Short name=InsP6 kinase 3
EC=2.7.4.21

Alternative name(s):
Inositol hexaphosphate kinase 3

Gene names

Name:	IP6K3
Synonyms:	IHPK3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	410 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. Ref.1
Catalytic activity	ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate. ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol diphosphate tetrakisphosphate (isomeric configuration unknown).
Subcellular location	Cytoplasm Ref.1.
Tissue specificity	Detected in brain.
Sequence similarities	Belongs to the inositol phosphokinase (IPK) family.
Sequence caution	The sequence BAB71225.2 differs from that shown. Reason: Frameshift at position 122.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Polymorphism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	inositol phosphate biosynthetic process Inferred from direct assay Ref.1. Source: MGI phosphatidylinositol metabolic process Inferred from direct assay Ref.1. Source: UniProtKB protein phosphorylation Inferred from direct assay Ref.1. Source: UniProtKB
Cellular_component	cytosol Traceable author statement. Source: Reactome nucleus Inferred from electronic annotation. Source: Compara
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW inositol hexakisphosphate 1-kinase activity Inferred from electronic annotation. Source: EC inositol hexakisphosphate 3-kinase activity Inferred from electronic annotation. Source: EC inositol hexakisphosphate 5-kinase activity Inferred from electronic annotation. Source: EC inositol hexakisphosphate 6-kinase activity Inferred from direct assay Ref.1. Source: MGI inositol-1,4,5-trisphosphate 3-kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 410	410	Inositol hexakisphosphate kinase 3		PRO_0000066881
Regions
	Region	211 – 219	9	Substrate binding By similarity
Natural variations
	Natural variant	60	1	R → W. Corresponds to variant rs34431226 [ dbSNP | Ensembl ].		VAR_031590
	Natural variant	308	1	A → V. Corresponds to variant rs34573836 [ dbSNP | Ensembl ].		VAR_031591
	Natural variant	312	1	V → I. Ref.2 Corresponds to variant rs4713668 [ dbSNP | Ensembl ].		VAR_031592
	Natural variant	378	1	Y → S. Corresponds to variant rs34343647 [ dbSNP | Ensembl ].		VAR_031593
Experimental info
	Mutagenesis	217	1	K → A: Loss of activity. Ref.1
	Mutagenesis	325	1	S → A: Strongly reduces activity. Ref.1
	Sequence conflict	56	1	L → Q in AAL17053. Ref.1
	Sequence conflict	304	1	H → L in BAB71225. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q96PC2 [UniParc]. Last modified April 3, 2007. Version 2. Checksum: CA61C7D4FA70F7F3	FASTA	410	46,417
	10 20 30 40 50 60 MVVQNSADAG DMRAGVQLEP FLHQVGGHMS VMKYDEHTVC KPLVSREQRF YESLPLAMKR 70 80 90 100 110 120 FTPQYKGTVT VHLWKDSTGH LSLVANPVKE SQEPFKVSTE SAAVAIWQTL QQTTGSNGSD 130 140 150 160 170 180 CTLAQWPHAQ LARSPKESPA KALLRSEPHL NTPAFSLVED TNGNQVERKS FNPWGLQCHQ 190 200 210 220 230 240 AHLTRLCSEY PENKRHRFLL LENVVSQYTH PCVLDLKMGT RQHGDDASEE KKARHMRKCA 250 260 270 280 290 300 QSTSACLGVR ICGMQVYQTD KKYFLCKDKY YGRKLSVEGF RQALYQFLHN GSHLRRELLE 310 320 330 340 350 360 PILHQLRALL SVIRSQSSYR FYSSSLLVIY DGQEPPERAP GSPHPHEAPQ AAHGSSPGGL 370 380 390 400 410 TKVDIRMIDF AHTTYKGYWN EHTTYDGPDP GYIFGLENLI RILQDIQEGE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and characterization of a novel inositol hexakisphosphate kinase." Saiardi A., Nagata E., Luo H.R., Snowman A.M., Snyder S.H. J. Biol. Chem. 276:39179-39185(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], MUTAGENESIS OF LYS-217 AND SER-325, FUNCTION, SUBCELLULAR LOCATION. Tissue: Brain.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ILE-312. Tissue: Tongue.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF393812 mRNA. Translation: AAL17053.1. AK056586 mRNA. Translation: BAB71225.2. Frameshift.
IPI	IPI00289690.
RefSeq	NP_001136355.1. NM_001142883.1. NP_473452.2. NM_054111.4.
UniGene	Hs.17253.
3D structure databases
ProteinModelPortal	Q96PC2.
SMR	Q96PC2. Positions 188-408.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000293756.
PTM databases
PhosphoSite	Q96PC2.
Polymorphism databases
DMDM	143811404.
Proteomic databases
PaxDb	Q96PC2.
PRIDE	Q96PC2.
Protocols and materials databases
DNASU	117283.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000293756; ENSP00000293756; ENSG00000161896. ENST00000451316; ENSP00000398861; ENSG00000161896.
GeneID	117283.
KEGG	hsa:117283.
UCSC	uc003ofb.2. human.
Organism-specific databases
CTD	117283.
GeneCards	GC06M033689.
HGNC	HGNC:17269. IP6K3.
MIM	606993. gene.
neXtProt	NX_Q96PC2.
PharmGKB	PA164721016.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG274869.
HOGENOM	HOG000007418.
HOVERGEN	HBG052140.
InParanoid	Q96PC2.
KO	K07756.
OMA	EHTTYDG.
OrthoDB	EOG4PZJ6N.
PhylomeDB	Q96PC2.
Enzyme and pathway databases
BioCyc	MetaCyc:HS08619-MONOMER.
Reactome	REACT_111217. Metabolism.
Gene expression databases
ArrayExpress	Q96PC2.
Bgee	Q96PC2.
CleanEx	HS_IP6K3.
Genevestigator	Q96PC2.
GermOnline	ENSG00000161896. Homo sapiens.
Family and domain databases
InterPro	IPR005522. IPK. [Graphical view]
PANTHER	PTHR12400. PTHR12400. 1 hit.
Pfam	PF03770. IPK. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	117283.
NextBio	80186.
SOURCE	Search...

Entry information

Entry name

IP6K3_HUMAN

Accession

Primary (citable) accession number: Q96PC2
Secondary accession number(s): Q96MQ9

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	April 3, 2007
Last modified:	May 29, 2013
This is version 100 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.