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Protein

Inositol hexakisphosphate kinase 3

Gene

IP6K3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4.1 Publication

Catalytic activityi

ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate.
ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.

GO - Molecular functioni

GO - Biological processi

  • inositol phosphate biosynthetic process Source: MGI
  • inositol phosphate metabolic process Source: Reactome
  • phosphatidylinositol metabolic process Source: UniProtKB
  • protein phosphorylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS08619-MONOMER.
ZFISH:HS08619-MONOMER.
BRENDAi2.7.4.21. 2681.
ReactomeiR-HSA-1855167. Synthesis of pyrophosphates in the cytosol.

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol hexakisphosphate kinase 3 (EC:2.7.4.21)
Short name:
InsP6 kinase 3
Alternative name(s):
Inositol hexaphosphate kinase 3
Gene namesi
Name:IP6K3
Synonyms:IHPK3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:17269. IP6K3.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytosol Source: Reactome
  • nucleus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi217K → A: Loss of activity. 1 Publication1
Mutagenesisi325S → A: Strongly reduces activity. 1 Publication1

Organism-specific databases

DisGeNETi117283.
OpenTargetsiENSG00000161896.
PharmGKBiPA164721016.

Polymorphism and mutation databases

BioMutaiIP6K3.
DMDMi143811404.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000668811 – 410Inositol hexakisphosphate kinase 3Add BLAST410

Proteomic databases

PaxDbiQ96PC2.
PeptideAtlasiQ96PC2.
PRIDEiQ96PC2.

PTM databases

iPTMnetiQ96PC2.
PhosphoSitePlusiQ96PC2.

Expressioni

Tissue specificityi

Detected in brain.

Gene expression databases

BgeeiENSG00000161896.
CleanExiHS_IP6K3.
ExpressionAtlasiQ96PC2. baseline and differential.
GenevisibleiQ96PC2. HS.

Organism-specific databases

HPAiHPA053644.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TRAF3Q131144EBI-10990676,EBI-357631

Protein-protein interaction databases

BioGridi125584. 17 interactors.
IntActiQ96PC2. 21 interactors.
STRINGi9606.ENSP00000293756.

Structurei

3D structure databases

ProteinModelPortaliQ96PC2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni211 – 219Substrate bindingBy similarity9

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IPEQ. Eukaryota.
ENOG4111UCF. LUCA.
GeneTreeiENSGT00390000014381.
HOGENOMiHOG000007418.
HOVERGENiHBG052140.
InParanoidiQ96PC2.
KOiK07756.
OMAiNEHTTYD.
OrthoDBiEOG091G0JK2.
PhylomeDBiQ96PC2.
TreeFamiTF314066.

Family and domain databases

InterProiIPR005522. IPK.
[Graphical view]
PANTHERiPTHR12400. PTHR12400. 2 hits.
PfamiPF03770. IPK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96PC2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVVQNSADAG DMRAGVQLEP FLHQVGGHMS VMKYDEHTVC KPLVSREQRF
60 70 80 90 100
YESLPLAMKR FTPQYKGTVT VHLWKDSTGH LSLVANPVKE SQEPFKVSTE
110 120 130 140 150
SAAVAIWQTL QQTTGSNGSD CTLAQWPHAQ LARSPKESPA KALLRSEPHL
160 170 180 190 200
NTPAFSLVED TNGNQVERKS FNPWGLQCHQ AHLTRLCSEY PENKRHRFLL
210 220 230 240 250
LENVVSQYTH PCVLDLKMGT RQHGDDASEE KKARHMRKCA QSTSACLGVR
260 270 280 290 300
ICGMQVYQTD KKYFLCKDKY YGRKLSVEGF RQALYQFLHN GSHLRRELLE
310 320 330 340 350
PILHQLRALL SVIRSQSSYR FYSSSLLVIY DGQEPPERAP GSPHPHEAPQ
360 370 380 390 400
AAHGSSPGGL TKVDIRMIDF AHTTYKGYWN EHTTYDGPDP GYIFGLENLI
410
RILQDIQEGE
Length:410
Mass (Da):46,417
Last modified:April 3, 2007 - v2
Checksum:iCA61C7D4FA70F7F3
GO

Sequence cautioni

The sequence BAB71225 differs from that shown. Reason: Frameshift at position 122.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti56L → Q in AAL17053 (PubMed:11502751).Curated1
Sequence conflicti304H → L in BAB71225 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03159060R → W.Corresponds to variant rs34431226dbSNPEnsembl.1
Natural variantiVAR_031591308A → V.Corresponds to variant rs34573836dbSNPEnsembl.1
Natural variantiVAR_031592312V → I.1 PublicationCorresponds to variant rs4713668dbSNPEnsembl.1
Natural variantiVAR_031593378Y → S.Corresponds to variant rs34343647dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF393812 mRNA. Translation: AAL17053.1.
AK056586 mRNA. Translation: BAB71225.2. Frameshift.
CCDSiCCDS34435.1.
RefSeqiNP_001136355.1. NM_001142883.1.
NP_473452.2. NM_054111.4.
XP_005248899.1. XM_005248842.3.
UniGeneiHs.17253.

Genome annotation databases

EnsembliENST00000293756; ENSP00000293756; ENSG00000161896.
ENST00000451316; ENSP00000398861; ENSG00000161896.
GeneIDi117283.
KEGGihsa:117283.
UCSCiuc003ofb.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF393812 mRNA. Translation: AAL17053.1.
AK056586 mRNA. Translation: BAB71225.2. Frameshift.
CCDSiCCDS34435.1.
RefSeqiNP_001136355.1. NM_001142883.1.
NP_473452.2. NM_054111.4.
XP_005248899.1. XM_005248842.3.
UniGeneiHs.17253.

3D structure databases

ProteinModelPortaliQ96PC2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125584. 17 interactors.
IntActiQ96PC2. 21 interactors.
STRINGi9606.ENSP00000293756.

PTM databases

iPTMnetiQ96PC2.
PhosphoSitePlusiQ96PC2.

Polymorphism and mutation databases

BioMutaiIP6K3.
DMDMi143811404.

Proteomic databases

PaxDbiQ96PC2.
PeptideAtlasiQ96PC2.
PRIDEiQ96PC2.

Protocols and materials databases

DNASUi117283.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000293756; ENSP00000293756; ENSG00000161896.
ENST00000451316; ENSP00000398861; ENSG00000161896.
GeneIDi117283.
KEGGihsa:117283.
UCSCiuc003ofb.3. human.

Organism-specific databases

CTDi117283.
DisGeNETi117283.
GeneCardsiIP6K3.
HGNCiHGNC:17269. IP6K3.
HPAiHPA053644.
MIMi606993. gene.
neXtProtiNX_Q96PC2.
OpenTargetsiENSG00000161896.
PharmGKBiPA164721016.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IPEQ. Eukaryota.
ENOG4111UCF. LUCA.
GeneTreeiENSGT00390000014381.
HOGENOMiHOG000007418.
HOVERGENiHBG052140.
InParanoidiQ96PC2.
KOiK07756.
OMAiNEHTTYD.
OrthoDBiEOG091G0JK2.
PhylomeDBiQ96PC2.
TreeFamiTF314066.

Enzyme and pathway databases

BioCyciMetaCyc:HS08619-MONOMER.
ZFISH:HS08619-MONOMER.
BRENDAi2.7.4.21. 2681.
ReactomeiR-HSA-1855167. Synthesis of pyrophosphates in the cytosol.

Miscellaneous databases

GenomeRNAii117283.
PROiQ96PC2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000161896.
CleanExiHS_IP6K3.
ExpressionAtlasiQ96PC2. baseline and differential.
GenevisibleiQ96PC2. HS.

Family and domain databases

InterProiIPR005522. IPK.
[Graphical view]
PANTHERiPTHR12400. PTHR12400. 2 hits.
PfamiPF03770. IPK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIP6K3_HUMAN
AccessioniPrimary (citable) accession number: Q96PC2
Secondary accession number(s): Q96MQ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: April 3, 2007
Last modified: November 30, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.