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Protein

Inositol hexakisphosphate kinase 3

Gene

IP6K3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4.1 Publication

Catalytic activityi

ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate.
ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. inositol-1,4,5-trisphosphate 3-kinase activity Source: InterPro
  3. inositol hexakisphosphate 1-kinase activity Source: UniProtKB-EC
  4. inositol hexakisphosphate 3-kinase activity Source: UniProtKB-EC
  5. inositol hexakisphosphate 5-kinase activity Source: UniProtKB-EC
  6. inositol hexakisphosphate 6-kinase activity Source: MGI

GO - Biological processi

  1. inositol phosphate biosynthetic process Source: MGI
  2. inositol phosphate metabolic process Source: Reactome
  3. phosphatidylinositol metabolic process Source: UniProtKB
  4. protein phosphorylation Source: UniProtKB
  5. small molecule metabolic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS08619-MONOMER.
ReactomeiREACT_150188. Synthesis of pyrophosphates in the cytosol.

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol hexakisphosphate kinase 3 (EC:2.7.4.21)
Short name:
InsP6 kinase 3
Alternative name(s):
Inositol hexaphosphate kinase 3
Gene namesi
Name:IP6K3
Synonyms:IHPK3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:17269. IP6K3.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. cytosol Source: Reactome
  3. nucleus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi217 – 2171K → A: Loss of activity. 1 Publication
Mutagenesisi325 – 3251S → A: Strongly reduces activity. 1 Publication

Organism-specific databases

PharmGKBiPA164721016.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 410410Inositol hexakisphosphate kinase 3PRO_0000066881Add
BLAST

Proteomic databases

PaxDbiQ96PC2.
PRIDEiQ96PC2.

PTM databases

PhosphoSiteiQ96PC2.

Expressioni

Tissue specificityi

Detected in brain.

Gene expression databases

BgeeiQ96PC2.
CleanExiHS_IP6K3.
ExpressionAtlasiQ96PC2. baseline and differential.
GenevestigatoriQ96PC2.

Organism-specific databases

HPAiHPA053644.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000293756.

Structurei

3D structure databases

ProteinModelPortaliQ96PC2.
SMRiQ96PC2. Positions 188-407.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni211 – 2199Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG274869.
GeneTreeiENSGT00390000014381.
HOGENOMiHOG000007418.
HOVERGENiHBG052140.
InParanoidiQ96PC2.
KOiK07756.
OMAiEHTTYDG.
OrthoDBiEOG747PHX.
PhylomeDBiQ96PC2.
TreeFamiTF314066.

Family and domain databases

InterProiIPR005522. IPK.
[Graphical view]
PANTHERiPTHR12400. PTHR12400. 1 hit.
PfamiPF03770. IPK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96PC2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVVQNSADAG DMRAGVQLEP FLHQVGGHMS VMKYDEHTVC KPLVSREQRF
60 70 80 90 100
YESLPLAMKR FTPQYKGTVT VHLWKDSTGH LSLVANPVKE SQEPFKVSTE
110 120 130 140 150
SAAVAIWQTL QQTTGSNGSD CTLAQWPHAQ LARSPKESPA KALLRSEPHL
160 170 180 190 200
NTPAFSLVED TNGNQVERKS FNPWGLQCHQ AHLTRLCSEY PENKRHRFLL
210 220 230 240 250
LENVVSQYTH PCVLDLKMGT RQHGDDASEE KKARHMRKCA QSTSACLGVR
260 270 280 290 300
ICGMQVYQTD KKYFLCKDKY YGRKLSVEGF RQALYQFLHN GSHLRRELLE
310 320 330 340 350
PILHQLRALL SVIRSQSSYR FYSSSLLVIY DGQEPPERAP GSPHPHEAPQ
360 370 380 390 400
AAHGSSPGGL TKVDIRMIDF AHTTYKGYWN EHTTYDGPDP GYIFGLENLI
410
RILQDIQEGE
Length:410
Mass (Da):46,417
Last modified:April 3, 2007 - v2
Checksum:iCA61C7D4FA70F7F3
GO

Sequence cautioni

The sequence BAB71225.2 differs from that shown. Reason: Frameshift at position 122. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti56 – 561L → Q in AAL17053 (PubMed:11502751).Curated
Sequence conflicti304 – 3041H → L in BAB71225 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti60 – 601R → W.
Corresponds to variant rs34431226 [ dbSNP | Ensembl ].
VAR_031590
Natural varianti308 – 3081A → V.
Corresponds to variant rs34573836 [ dbSNP | Ensembl ].
VAR_031591
Natural varianti312 – 3121V → I.1 Publication
Corresponds to variant rs4713668 [ dbSNP | Ensembl ].
VAR_031592
Natural varianti378 – 3781Y → S.
Corresponds to variant rs34343647 [ dbSNP | Ensembl ].
VAR_031593

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF393812 mRNA. Translation: AAL17053.1.
AK056586 mRNA. Translation: BAB71225.2. Frameshift.
CCDSiCCDS34435.1.
RefSeqiNP_001136355.1. NM_001142883.1.
NP_473452.2. NM_054111.4.
XP_005248899.1. XM_005248842.1.
UniGeneiHs.17253.

Genome annotation databases

EnsembliENST00000293756; ENSP00000293756; ENSG00000161896.
ENST00000451316; ENSP00000398861; ENSG00000161896.
GeneIDi117283.
KEGGihsa:117283.
UCSCiuc003ofb.2. human.

Polymorphism databases

DMDMi143811404.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF393812 mRNA. Translation: AAL17053.1.
AK056586 mRNA. Translation: BAB71225.2. Frameshift.
CCDSiCCDS34435.1.
RefSeqiNP_001136355.1. NM_001142883.1.
NP_473452.2. NM_054111.4.
XP_005248899.1. XM_005248842.1.
UniGeneiHs.17253.

3D structure databases

ProteinModelPortaliQ96PC2.
SMRiQ96PC2. Positions 188-407.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000293756.

PTM databases

PhosphoSiteiQ96PC2.

Polymorphism databases

DMDMi143811404.

Proteomic databases

PaxDbiQ96PC2.
PRIDEiQ96PC2.

Protocols and materials databases

DNASUi117283.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000293756; ENSP00000293756; ENSG00000161896.
ENST00000451316; ENSP00000398861; ENSG00000161896.
GeneIDi117283.
KEGGihsa:117283.
UCSCiuc003ofb.2. human.

Organism-specific databases

CTDi117283.
GeneCardsiGC06M033689.
HGNCiHGNC:17269. IP6K3.
HPAiHPA053644.
MIMi606993. gene.
neXtProtiNX_Q96PC2.
PharmGKBiPA164721016.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG274869.
GeneTreeiENSGT00390000014381.
HOGENOMiHOG000007418.
HOVERGENiHBG052140.
InParanoidiQ96PC2.
KOiK07756.
OMAiEHTTYDG.
OrthoDBiEOG747PHX.
PhylomeDBiQ96PC2.
TreeFamiTF314066.

Enzyme and pathway databases

BioCyciMetaCyc:HS08619-MONOMER.
ReactomeiREACT_150188. Synthesis of pyrophosphates in the cytosol.

Miscellaneous databases

GenomeRNAii117283.
NextBioi80186.
PROiQ96PC2.
SOURCEiSearch...

Gene expression databases

BgeeiQ96PC2.
CleanExiHS_IP6K3.
ExpressionAtlasiQ96PC2. baseline and differential.
GenevestigatoriQ96PC2.

Family and domain databases

InterProiIPR005522. IPK.
[Graphical view]
PANTHERiPTHR12400. PTHR12400. 1 hit.
PfamiPF03770. IPK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of a novel inositol hexakisphosphate kinase."
    Saiardi A., Nagata E., Luo H.R., Snowman A.M., Snyder S.H.
    J. Biol. Chem. 276:39179-39185(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], MUTAGENESIS OF LYS-217 AND SER-325, FUNCTION, SUBCELLULAR LOCATION.
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ILE-312.
    Tissue: Tongue.

Entry informationi

Entry nameiIP6K3_HUMAN
AccessioniPrimary (citable) accession number: Q96PC2
Secondary accession number(s): Q96MQ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: April 3, 2007
Last modified: January 7, 2015
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.