Q96PB7 (NOE3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Noelin-3

Alternative name(s):
Olfactomedin-3
Optimedin

Gene names

Name:	OLFM3
Synonyms:	NOE3
ORF Names:	UNQ1924/PRO4399

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	478 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Homodimer. Interacts with MYOC By similarity.
Subcellular location	Secreted By similarity.
Tissue specificity	In the eye, expressed in trabecular meshwork and neural retina; in non-ocular tissues, expressed in brain and lung. Ref.5
Sequence similarities	Contains 1 olfactomedin-like domain.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Alternative splicing
Domain	Coiled coil Signal
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96PB7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96PB7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     218-235: TCGKLMKITGPVTVKTSG → IDLKKRKEEEKRQQKGEA
     236-478: Missing.

Isoform 3 (identifier: Q96PB7-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-43: MSPPLLKLGAVLSTMAMISNWMSQTLPSLVGLNTTRLSTPDTL → MQATSNLLNLLLLSLFAGLDPSK

Isoform 4 (identifier: Q96PB7-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-43: MSPPLLKLGAVLSTMAMISNWMSQTLPSLVGLNTTRLSTPDTL → MQATSNLLNLLLLSLFAGLDPSK
     218-235: TCGKLMKITGPVTVKTSG → IDLKKRKEEEKRQQKGEA
     236-478: Missing.

Isoform 5 (identifier: Q96PB7-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-95: Missing.

Isoform 6 (identifier: Q96PB7-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1-95: Missing.
     218-235: TCGKLMKITGPVTVKTSG → IDLKKRKEEEKRQQKGEA
     236-478: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Chain	24 – 478	455	Noelin-3		PRO_0000020080
Regions
	Domain	218 – 470	253	Olfactomedin-like
	Coiled coil	77 – 217	141	Potential
Amino acid modifications
	Modified residue	140	1	Phosphothreonine Ref.7
	Glycosylation	33	1	N-linked (GlcNAc...) Potential
	Glycosylation	95	1	N-linked (GlcNAc...) Potential
	Glycosylation	179	1	N-linked (GlcNAc...) Potential
	Glycosylation	299	1	N-linked (GlcNAc...) Potential
	Glycosylation	465	1	N-linked (GlcNAc...) Potential
	Disulfide bond	219 ↔ 401		By similarity
Natural variations
	Alternative sequence	1 – 95	95	Missing in isoform 5 and isoform 6.		VSP_003770
	Alternative sequence	1 – 43	43	MSPPL…TPDTL → MQATSNLLNLLLLSLFAGLD PSK in isoform 3 and isoform 4.		VSP_003769
	Alternative sequence	218 – 235	18	TCGKL…VKTSG → IDLKKRKEEEKRQQKGEA in isoform 2, isoform 4 and isoform 6.		VSP_003771
	Alternative sequence	236 – 478	243	Missing in isoform 2, isoform 4 and isoform 6.		VSP_003772
Experimental info
	Sequence conflict	88	1	Q → K in AAH22531. Ref.4
	Sequence conflict	454	1	Y → C in AAH22531. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 02EAAF58741489E5	FASTA	478	54,930
	10 20 30 40 50 60 MSPPLLKLGA VLSTMAMISN WMSQTLPSLV GLNTTRLSTP DTLTQISPKE GWQVYSSAQD 70 80 90 100 110 120 PDGRCICTVV APEQNLCSRD AKSRQLRQLL EKVQNMSQSI EVLNLRTQRD FQYVLKMETQ 130 140 150 160 170 180 MKGLKAKFRQ IEDDRKTLMT KHFQELKEKM DELLPLIPVL EQYKTDAKLI TQFKEEIRNL 190 200 210 220 230 240 SAVLTGIQEE IGAYDYEELH QRVLSLETRL RDCMKKLTCG KLMKITGPVT VKTSGTRFGA 250 260 270 280 290 300 WMTDPLASEK NNRVWYMDSY TNNKIVREYK SIADFVSGAE SRTYNLPFKW AGTNHVVYNG 310 320 330 340 350 360 SLYFNKYQSN IIIKYSFDMG RVLAQRSLEY AGFHNVYPYT WGGFSDIDLM ADEIGLWAVY 370 380 390 400 410 420 ATNQNAGNIV ISQLNQDTLE VMKSWSTGYP KRSAGESFMI CGTLYVTNSH LTGAKVYYSY 430 440 450 460 470 STKTSTYEYT DIPFHNQYFH ISMLDYNARD RALYAWNNGH QVLFNVTLFH IIKTEDDT
	Isoform 2 [UniParc]. Checksum: B27366B01FB042F5	FASTA	235	27,218
	10 20 30 40 50 60 MSPPLLKLGA VLSTMAMISN WMSQTLPSLV GLNTTRLSTP DTLTQISPKE GWQVYSSAQD 70 80 90 100 110 120 PDGRCICTVV APEQNLCSRD AKSRQLRQLL EKVQNMSQSI EVLNLRTQRD FQYVLKMETQ 130 140 150 160 170 180 MKGLKAKFRQ IEDDRKTLMT KHFQELKEKM DELLPLIPVL EQYKTDAKLI TQFKEEIRNL 190 200 210 220 230 SAVLTGIQEE IGAYDYEELH QRVLSLETRL RDCMKKLIDL KKRKEEEKRQ QKGEA
	Isoform 3 [UniParc]. Checksum: 0A7C25D9E84755FC	FASTA	458	52,801
	10 20 30 40 50 60 MQATSNLLNL LLLSLFAGLD PSKTQISPKE GWQVYSSAQD PDGRCICTVV APEQNLCSRD 70 80 90 100 110 120 AKSRQLRQLL EKVQNMSQSI EVLNLRTQRD FQYVLKMETQ MKGLKAKFRQ IEDDRKTLMT 130 140 150 160 170 180 KHFQELKEKM DELLPLIPVL EQYKTDAKLI TQFKEEIRNL SAVLTGIQEE IGAYDYEELH 190 200 210 220 230 240 QRVLSLETRL RDCMKKLTCG KLMKITGPVT VKTSGTRFGA WMTDPLASEK NNRVWYMDSY 250 260 270 280 290 300 TNNKIVREYK SIADFVSGAE SRTYNLPFKW AGTNHVVYNG SLYFNKYQSN IIIKYSFDMG 310 320 330 340 350 360 RVLAQRSLEY AGFHNVYPYT WGGFSDIDLM ADEIGLWAVY ATNQNAGNIV ISQLNQDTLE 370 380 390 400 410 420 VMKSWSTGYP KRSAGESFMI CGTLYVTNSH LTGAKVYYSY STKTSTYEYT DIPFHNQYFH 430 440 450 ISMLDYNARD RALYAWNNGH QVLFNVTLFH IIKTEDDT
	Isoform 4 [UniParc]. Checksum: 5B898299AFC1837E	FASTA	215	25,089
	10 20 30 40 50 60 MQATSNLLNL LLLSLFAGLD PSKTQISPKE GWQVYSSAQD PDGRCICTVV APEQNLCSRD 70 80 90 100 110 120 AKSRQLRQLL EKVQNMSQSI EVLNLRTQRD FQYVLKMETQ MKGLKAKFRQ IEDDRKTLMT 130 140 150 160 170 180 KHFQELKEKM DELLPLIPVL EQYKTDAKLI TQFKEEIRNL SAVLTGIQEE IGAYDYEELH 190 200 210 QRVLSLETRL RDCMKKLIDL KKRKEEEKRQ QKGEA
	Isoform 5 [UniParc]. Checksum: 895CD21DBC660834	FASTA	383	44,502
	10 20 30 40 50 60 MSQSIEVLNL RTQRDFQYVL KMETQMKGLK AKFRQIEDDR KTLMTKHFQE LKEKMDELLP 70 80 90 100 110 120 LIPVLEQYKT DAKLITQFKE EIRNLSAVLT GIQEEIGAYD YEELHQRVLS LETRLRDCMK 130 140 150 160 170 180 KLTCGKLMKI TGPVTVKTSG TRFGAWMTDP LASEKNNRVW YMDSYTNNKI VREYKSIADF 190 200 210 220 230 240 VSGAESRTYN LPFKWAGTNH VVYNGSLYFN KYQSNIIIKY SFDMGRVLAQ RSLEYAGFHN 250 260 270 280 290 300 VYPYTWGGFS DIDLMADEIG LWAVYATNQN AGNIVISQLN QDTLEVMKSW STGYPKRSAG 310 320 330 340 350 360 ESFMICGTLY VTNSHLTGAK VYYSYSTKTS TYEYTDIPFH NQYFHISMLD YNARDRALYA 370 380 WNNGHQVLFN VTLFHIIKTE DDT
	Isoform 6 [UniParc]. Checksum: 504964995B04DF3C	FASTA	140	16,790
	10 20 30 40 50 60 MSQSIEVLNL RTQRDFQYVL KMETQMKGLK AKFRQIEDDR KTLMTKHFQE LKEKMDELLP 70 80 90 100 110 120 LIPVLEQYKT DAKLITQFKE EIRNLSAVLT GIQEEIGAYD YEELHQRVLS LETRLRDCMK 130 140 KLIDLKKRKE EEKRQQKGEA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"NOE3: a novel olfactomedin/noelin/pancortin homolog identified near an ependymoma-associated translocation breakpoint." Rhodes C.H., Call K.M., Little R., Braunschweiger K., Park J.P. Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4; 5 AND 6).
[2]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Hippocampus.
[5]	"Optimedin: a novel olfactomedin-related protein that interacts with myocilin." Torrado M., Trivedi R., Zinovieva R., Karavanova I., Tomarev S.I. Hum. Mol. Genet. 11:1291-1301(2002) [PubMed: 12019210] [Abstract] Cited for: TISSUE SPECIFICITY.
[6]	"Bioinformatic approaches for identification and characterization of olfactomedin related genes with a potential role in pathogenesis of ocular disorders." Mukhopadhyay A., Talukdar S., Bhattacharjee A., Ray K. Mol. Vis. 10:304-314(2004) [PubMed: 15123989] [Abstract] Cited for: ALTERNATIVE SPLICING.
[7]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-140, MASS SPECTROMETRY. Tissue: Embryonic kidney.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF397392 mRNA. Translation: AAK97473.1. AF397393 mRNA. Translation: AAK97474.1. AF397394 mRNA. Translation: AAK97475.1. AF397395 mRNA. Translation: AAK97476.1. AF397396 mRNA. Translation: AAK97477.1. AF397397 mRNA. Translation: AAK97478.1. AY358722 mRNA. Translation: AAQ89084.1. CH471097 Genomic DNA. Translation: EAW72922.1. BC022531 mRNA. Translation: AAH22531.1. BK001429 Genomic DNA. Translation: DAA01553.1. BK001429 Genomic DNA. Translation: DAA01554.1. BK001429 Genomic DNA. Translation: DAA01555.1. BK001429 Genomic DNA. Translation: DAA01556.1.
IPI	IPI00000390. IPI00219998. IPI00219999. IPI00220000. IPI00220001. IPI00220003.
RefSeq	NP_477518.2. NM_058170.2.
UniGene	Hs.484475.
3D structure databases
ProteinModelPortal	Q96PB7.
ModBase	Search...
Protein-protein interaction databases
STRING	Q96PB7.
PTM databases
PhosphoSite	Q96PB7.
Polymorphism databases
DMDM	20139068.
Proteomic databases
PRIDE	Q96PB7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000338858; ENSP00000345192; ENSG00000118733.
GeneID	118427.
KEGG	hsa:118427.
UCSC	uc001duf.2. human. uc001dug.2. human.
Organism-specific databases
CTD	118427.
GeneCards	GC01M102268.
HGNC	HGNC:17990. OLFM3.
MIM	607567. gene.
neXtProt	NX_Q96PB7.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00560000076789.
HOVERGEN	HBG006513.
InParanoid	Q96PB7.
OMA	SFDMGRV.
PhylomeDB	Q96PB7.
Gene expression databases
ArrayExpress	Q96PB7.
Bgee	Q96PB7.
CleanEx	HS_OLFM3.
Genevestigator	Q96PB7.
GermOnline	ENSG00000118733. Homo sapiens.
Family and domain databases
InterPro	IPR022082. Noelin-1. IPR003112. Olfac-like. [Graphical view]
Pfam	PF12308. Noelin-1. 1 hit. PF02191. OLF. 1 hit. [Graphical view]
SMART	SM00284. OLF. 1 hit. [Graphical view]
PROSITE	PS51132. OLF. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	80270.
SOURCE	Search...

Entry information

Entry name

NOE3_HUMAN

Accession

Primary (citable) accession number: Q96PB7
Secondary accession number(s): Q6IMI7 , Q6IMI8, Q6IMI9, Q6IMJ1, Q8TBG1, Q96PB2, Q96PB3, Q96PB4, Q96PB5, Q96PB6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
Last sequence update:	December 1, 2001
Last modified:	January 25, 2012
This is version 91 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.