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Protein

Putative gonadotropin-releasing hormone II receptor

Gene

GNRHR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein uncertaini

Functioni

Putative receptor for gonadotropin releasing hormone II (GnRH II) which is most probably non-functional.2 Publications

Caution

Could be the product of a pseudogene. A frameshift introducing a premature stop codon in exon 1 most probably results in the inactivation of that transcribed gene in human. However, alternative splicing may allow the production of a truncated but possibly functional protein containing 5 transmembrane domains which is shown here.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-375281 Hormone ligand-binding receptors
R-HSA-416476 G alpha (q) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Putative gonadotropin-releasing hormone II receptor
Short name:
GnRH II receptor
Short name:
GnRH-II-R
Alternative name(s):
Type II GnRH receptor
Gene namesi
Name:GNRHR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:16341 GNRHR2
MIMi612875 gene
neXtProtiNX_Q96P88

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 28ExtracellularSequence analysisAdd BLAST28
Transmembranei29 – 49Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini50 – 67CytoplasmicSequence analysisAdd BLAST18
Transmembranei68 – 88Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini89 – 115ExtracellularSequence analysisAdd BLAST27
Transmembranei116 – 136Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini137 – 177CytoplasmicSequence analysisAdd BLAST41
Transmembranei178 – 198Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini199 – 216ExtracellularSequence analysisAdd BLAST18
Transmembranei217 – 237Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini238 – 292CytoplasmicSequence analysisAdd BLAST55

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi114814
MalaCardsiGNRHR2

Chemistry databases

DrugBankiDB01406 Danazol
DB00644 Gonadorelin
DB00666 Nafarelin

Polymorphism and mutation databases

DMDMi408360337

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000694971 – 292Putative gonadotropin-releasing hormone II receptorAdd BLAST292

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi26 ↔ 101PROSITE-ProRule annotation

Post-translational modificationi

Phosphorylated on the C-terminal cytoplasmic tail.Curated

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiQ96P88
PRIDEiQ96P88

PTM databases

PhosphoSitePlusiQ96P88

Expressioni

Tissue specificityi

Expressed in many tissues.1 Publication

Gene expression databases

CleanExiHS_GNRHR2

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000354569

Structurei

3D structure databases

ProteinModelPortaliQ96P88
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
HOVERGENiHBG107957
InParanoidiQ96P88
TreeFamiTF106499

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR027983 GphnRH_2_rcpt
IPR001658 GphnRH_fam_rcpt
PANTHERiPTHR24241:SF116 PTHR24241:SF116, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00529 GNADOTRPHINR
PR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q96P88-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAGNGTPWD ATWNITVQWL AVDIACRTLM FLKLMATYSA AFLPVVIGLD
60 70 80 90 100
RQAAVLNPLG SRSGVRKLLG AAWGLSFLLA FPQLFLFHTV HCAGPVPFTQ
110 120 130 140 150
CVTKGSFKAQ WQETTYNLFT FCCLFLLPLT AMAICYSRIV LSVSRPQTRK
160 170 180 190 200
GSHAPAGEFA LPRSFDNCPR VRLRALRLAL LILLTFILCW TPYYLLGMWY
210 220 230 240 250
WFSPTMLTEV PPSLSHILFL LGLLNAPLDP LLYGAFTLGC RRGHQELSID
260 270 280 290
SSKEGSGRML QEEIHAFRQL EVQKTVTSRR AGETKGISIT SI
Length:292
Mass (Da):32,537
Last modified:October 3, 2012 - v4
Checksum:iCB8E31DABE8030FC
GO

Sequence cautioni

The sequence AAL27000 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti96V → D in AAL89821 (PubMed:11861490).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF403014 Genomic DNA Translation: AAL27000.1 Sequence problems.
AY081843 mRNA Translation: AAL89821.1
AL160282 Genomic DNA No translation available.
UniGeneiHs.356873
Hs.711567

Similar proteinsi

Entry informationi

Entry nameiGNRR2_HUMAN
AccessioniPrimary (citable) accession number: Q96P88
Secondary accession number(s): E7EN27, Q8TCX8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: October 3, 2012
Last modified: May 23, 2018
This is version 132 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

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