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Protein

Putative gonadotropin-releasing hormone II receptor

Gene

GNRHR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein uncertaini

Functioni

Putative receptor for gonadotropin releasing hormone II (GnRH II) which is most probably non-functional.2 Publications

GO - Molecular functioni

  1. gonadotropin-releasing hormone receptor activity Source: GO_Central
  2. peptide binding Source: GO_Central

GO - Biological processi

  1. cellular response to gonadotropin-releasing hormone Source: GO_Central
  2. G-protein coupled receptor signaling pathway Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_16942. Hormone ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative gonadotropin-releasing hormone II receptor
Short name:
GnRH II receptor
Short name:
GnRH-II-R
Alternative name(s):
Type II GnRH receptor
Gene namesi
Name:GNRHR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:16341. GNRHR2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2828ExtracellularSequence AnalysisAdd
BLAST
Transmembranei29 – 4921Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini50 – 6718CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei68 – 8821Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini89 – 11527ExtracellularSequence AnalysisAdd
BLAST
Transmembranei116 – 13621Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini137 – 17741CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei178 – 19821Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini199 – 21618ExtracellularSequence AnalysisAdd
BLAST
Transmembranei217 – 23721Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini238 – 29255CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: GO_Central
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

DrugBankiDB01406. Danazol.
DB00644. Gonadorelin.
DB00666. Nafarelin.

Polymorphism and mutation databases

DMDMi408360337.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 292292Putative gonadotropin-releasing hormone II receptorPRO_0000069497Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi26 ↔ 101PROSITE-ProRule annotation

Post-translational modificationi

Phosphorylated on the C-terminal cytoplasmic tail.Curated

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PRIDEiQ96P88.

PTM databases

PhosphoSiteiQ96P88.

Expressioni

Tissue specificityi

Expressed in many tissues.1 Publication

Gene expression databases

CleanExiHS_GNRHR2.
GenevestigatoriQ96P88.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000354569.

Structurei

3D structure databases

ProteinModelPortaliQ96P88.
SMRiQ96P88. Positions 12-242.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG277514.
HOVERGENiHBG107957.
InParanoidiQ96P88.
OrthoDBiEOG7SJD52.
TreeFamiTF106499.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR027983. GphnRH_2_rcpt.
IPR001658. GphnRH_fam_rcpt.
[Graphical view]
PANTHERiPTHR24241:SF66. PTHR24241:SF66. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00529. GNADOTRPHINR.
PR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96P88-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAGNGTPWD ATWNITVQWL AVDIACRTLM FLKLMATYSA AFLPVVIGLD
60 70 80 90 100
RQAAVLNPLG SRSGVRKLLG AAWGLSFLLA FPQLFLFHTV HCAGPVPFTQ
110 120 130 140 150
CVTKGSFKAQ WQETTYNLFT FCCLFLLPLT AMAICYSRIV LSVSRPQTRK
160 170 180 190 200
GSHAPAGEFA LPRSFDNCPR VRLRALRLAL LILLTFILCW TPYYLLGMWY
210 220 230 240 250
WFSPTMLTEV PPSLSHILFL LGLLNAPLDP LLYGAFTLGC RRGHQELSID
260 270 280 290
SSKEGSGRML QEEIHAFRQL EVQKTVTSRR AGETKGISIT SI
Length:292
Mass (Da):32,537
Last modified:October 3, 2012 - v4
Checksum:iCB8E31DABE8030FC
GO

Sequence cautioni

The sequence AAL27000.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti96 – 961V → D in AAL89821 (PubMed:11861490).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF403014 Genomic DNA. Translation: AAL27000.1. Sequence problems.
AY081843 mRNA. Translation: AAL89821.1.
AL160282 Genomic DNA. No translation available.
UniGeneiHs.356873.
Hs.711567.

Genome annotation databases

EnsembliENST00000361928; ENSP00000354569; ENSG00000211451.
UCSCiuc009wiv.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF403014 Genomic DNA. Translation: AAL27000.1. Sequence problems.
AY081843 mRNA. Translation: AAL89821.1.
AL160282 Genomic DNA. No translation available.
UniGeneiHs.356873.
Hs.711567.

3D structure databases

ProteinModelPortaliQ96P88.
SMRiQ96P88. Positions 12-242.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000354569.

Chemistry

DrugBankiDB01406. Danazol.
DB00644. Gonadorelin.
DB00666. Nafarelin.
GuidetoPHARMACOLOGYi257.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ96P88.

Polymorphism and mutation databases

DMDMi408360337.

Proteomic databases

PRIDEiQ96P88.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361928; ENSP00000354569; ENSG00000211451.
UCSCiuc009wiv.3. human.

Organism-specific databases

GeneCardsiGC01M145509.
HGNCiHGNC:16341. GNRHR2.
MIMi612875. gene.
neXtProtiNX_Q96P88.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG277514.
HOVERGENiHBG107957.
InParanoidiQ96P88.
OrthoDBiEOG7SJD52.
TreeFamiTF106499.

Enzyme and pathway databases

ReactomeiREACT_16942. Hormone ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.

Miscellaneous databases

PROiQ96P88.
SOURCEiSearch...

Gene expression databases

CleanExiHS_GNRHR2.
GenevestigatoriQ96P88.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR027983. GphnRH_2_rcpt.
IPR001658. GphnRH_fam_rcpt.
[Graphical view]
PANTHERiPTHR24241:SF66. PTHR24241:SF66. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00529. GNADOTRPHINR.
PR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genes encoding the type II gonadotropin-releasing hormone receptor and the ribonucleoprotein RBM8A in humans overlap in two genomic loci."
    Faurholm B., Millar R.P., Katz A.A.
    Genomics 78:15-18(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Minireview: GnRH and GnRH receptor genes in the human genome."
    Neill J.D.
    Endocrinology 143:737-743(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
    Tissue: Testis.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "A transcriptionally active human type II gonadotropin-releasing hormone receptor gene homolog overlaps two genes in the antisense orientation on chromosome 1q.12."
    Morgan K., Conklin D., Pawson A.J., Sellar R., Ott T.R., Millar R.P.
    Endocrinology 144:423-436(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "Retention and silencing of prepro-GnRH-II and type II GnRH receptor genes in mammals."
    Stewart A.J., Katz A.A., Millar R.P., Morgan K.
    Neuroendocrinology 90:416-432(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiGNRR2_HUMAN
AccessioniPrimary (citable) accession number: Q96P88
Secondary accession number(s): E7EN27, Q8TCX8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: October 3, 2012
Last modified: February 4, 2015
This is version 116 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene. A frameshift introducing a premature stop codon in exon 1 most probably results in the inactivation of that transcribed gene in human. However, alternative splicing may allow the production of a truncated but possibly functional protein containing 5 transmembrane domains which is shown here.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.