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Q96P88 (GNRR2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative gonadotropin-releasing hormone II receptor

Short name=GnRH II receptor
Short name=GnRH-II-R
Alternative name(s):
Type II GnRH receptor
Gene names
Name:GNRHR2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length292 AA.
Sequence statusComplete.
Protein existenceUncertain

General annotation (Comments)

Function

Putative receptor for gonadotropin releasing hormone II (GnRH II) which is most probably non-functional. Ref.4 Ref.5

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Expressed in many tissues. Ref.2

Post-translational modification

Phosphorylated on the C-terminal cytoplasmic tail Probable.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Caution

Could be the product of a pseudogene. A frameshift introducing a premature stop codon in exon 1 most probably results in the inactivation of that transcribed gene in human. However, alternative splicing may allow the production of a truncated but possibly functional protein containing 5 transmembrane domains which is shown here.

Sequence caution

The sequence AAL27000.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 292292Putative gonadotropin-releasing hormone II receptor
PRO_0000069497

Regions

Topological domain1 – 2828Extracellular Potential
Transmembrane29 – 4921Helical; Name=1; Potential
Topological domain50 – 6718Cytoplasmic Potential
Transmembrane68 – 8821Helical; Name=2; Potential
Topological domain89 – 11527Extracellular Potential
Transmembrane116 – 13621Helical; Name=3; Potential
Topological domain137 – 17741Cytoplasmic Potential
Transmembrane178 – 19821Helical; Name=4; Potential
Topological domain199 – 21618Extracellular Potential
Transmembrane217 – 23721Helical; Name=5; Potential
Topological domain238 – 29255Cytoplasmic Potential

Amino acid modifications

Disulfide bond26 ↔ 101 By similarity

Experimental info

Sequence conflict961V → D in AAL89821. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q96P88 [UniParc].

Last modified October 3, 2012. Version 4.
Checksum: CB8E31DABE8030FC

FASTA29232,537
        10         20         30         40         50         60 
MSAGNGTPWD ATWNITVQWL AVDIACRTLM FLKLMATYSA AFLPVVIGLD RQAAVLNPLG 

        70         80         90        100        110        120 
SRSGVRKLLG AAWGLSFLLA FPQLFLFHTV HCAGPVPFTQ CVTKGSFKAQ WQETTYNLFT 

       130        140        150        160        170        180 
FCCLFLLPLT AMAICYSRIV LSVSRPQTRK GSHAPAGEFA LPRSFDNCPR VRLRALRLAL 

       190        200        210        220        230        240 
LILLTFILCW TPYYLLGMWY WFSPTMLTEV PPSLSHILFL LGLLNAPLDP LLYGAFTLGC 

       250        260        270        280        290 
RRGHQELSID SSKEGSGRML QEEIHAFRQL EVQKTVTSRR AGETKGISIT SI 

« Hide

References

« Hide 'large scale' references
[1]"The genes encoding the type II gonadotropin-releasing hormone receptor and the ribonucleoprotein RBM8A in humans overlap in two genomic loci."
Faurholm B., Millar R.P., Katz A.A.
Genomics 78:15-18(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Minireview: GnRH and GnRH receptor genes in the human genome."
Neill J.D.
Endocrinology 143:737-743(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
Tissue: Testis.
[3]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"A transcriptionally active human type II gonadotropin-releasing hormone receptor gene homolog overlaps two genes in the antisense orientation on chromosome 1q.12."
Morgan K., Conklin D., Pawson A.J., Sellar R., Ott T.R., Millar R.P.
Endocrinology 144:423-436(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[5]"Retention and silencing of prepro-GnRH-II and type II GnRH receptor genes in mammals."
Stewart A.J., Katz A.A., Millar R.P., Morgan K.
Neuroendocrinology 90:416-432(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF403014 Genomic DNA. Translation: AAL27000.1. Sequence problems.
AY081843 mRNA. Translation: AAL89821.1.
AL160282 Genomic DNA. No translation available.
UniGeneHs.356873.
Hs.711567.

3D structure databases

ProteinModelPortalQ96P88.
SMRQ96P88. Positions 12-234.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000354569.

Chemistry

DrugBankDB01406. Danazol.
DB00644. Gonadorelin.
DB00666. Nafarelin.
GuidetoPHARMACOLOGY257.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ96P88.

Polymorphism databases

DMDM408360337.

Proteomic databases

PRIDEQ96P88.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000361928; ENSP00000354569; ENSG00000211451.
UCSCuc009wiv.3. human.

Organism-specific databases

GeneCardsGC01M145509.
HGNCHGNC:16341. GNRHR2.
MIM612875. gene.
neXtProtNX_Q96P88.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG277514.
HOVERGENHBG107957.
OrthoDBEOG7SJD52.
TreeFamTF106499.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_GNRHR2.
GenevestigatorQ96P88.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR027983. GphnRH_2_rcpt.
IPR001658. GphnRH_fam_rcpt.
[Graphical view]
PANTHERPTHR24241:SF23. PTHR24241:SF23. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00529. GNADOTRPHINR.
PR00237. GPCRRHODOPSN.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ96P88.
SOURCESearch...

Entry information

Entry nameGNRR2_HUMAN
AccessionPrimary (citable) accession number: Q96P88
Secondary accession number(s): E7EN27, Q8TCX8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: October 3, 2012
Last modified: April 16, 2014
This is version 109 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries