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Q96P88

- GNRR2_HUMAN

UniProt

Q96P88 - GNRR2_HUMAN

Protein

Putative gonadotropin-releasing hormone II receptor

Gene

GNRHR2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Protein uncertaini
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 4 (03 Oct 2012)
      Previous versions | rss
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    Functioni

    Putative receptor for gonadotropin releasing hormone II (GnRH II) which is most probably non-functional.2 Publications

    GO - Molecular functioni

    1. gonadotropin-releasing hormone receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_16942. Hormone ligand-binding receptors.
    REACT_18283. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative gonadotropin-releasing hormone II receptor
    Short name:
    GnRH II receptor
    Short name:
    GnRH-II-R
    Alternative name(s):
    Type II GnRH receptor
    Gene namesi
    Name:GNRHR2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:16341. GNRHR2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 292292Putative gonadotropin-releasing hormone II receptorPRO_0000069497Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi26 ↔ 101PROSITE-ProRule annotation

    Post-translational modificationi

    Phosphorylated on the C-terminal cytoplasmic tail.Curated

    Keywords - PTMi

    Disulfide bond, Phosphoprotein

    Proteomic databases

    PRIDEiQ96P88.

    PTM databases

    PhosphoSiteiQ96P88.

    Expressioni

    Tissue specificityi

    Expressed in many tissues.1 Publication

    Gene expression databases

    CleanExiHS_GNRHR2.
    GenevestigatoriQ96P88.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000354569.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96P88.
    SMRiQ96P88. Positions 12-242.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2828ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini50 – 6718CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini89 – 11527ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini137 – 17741CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini199 – 21618ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini238 – 29255CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei29 – 4921Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei68 – 8821Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei116 – 13621Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei178 – 19821Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei217 – 23721Helical; Name=5Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG277514.
    HOVERGENiHBG107957.
    OrthoDBiEOG7SJD52.
    TreeFamiTF106499.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR027983. GphnRH_2_rcpt.
    IPR001658. GphnRH_fam_rcpt.
    [Graphical view]
    PANTHERiPTHR24241:SF66. PTHR24241:SF66. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00529. GNADOTRPHINR.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96P88-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSAGNGTPWD ATWNITVQWL AVDIACRTLM FLKLMATYSA AFLPVVIGLD    50
    RQAAVLNPLG SRSGVRKLLG AAWGLSFLLA FPQLFLFHTV HCAGPVPFTQ 100
    CVTKGSFKAQ WQETTYNLFT FCCLFLLPLT AMAICYSRIV LSVSRPQTRK 150
    GSHAPAGEFA LPRSFDNCPR VRLRALRLAL LILLTFILCW TPYYLLGMWY 200
    WFSPTMLTEV PPSLSHILFL LGLLNAPLDP LLYGAFTLGC RRGHQELSID 250
    SSKEGSGRML QEEIHAFRQL EVQKTVTSRR AGETKGISIT SI 292
    Length:292
    Mass (Da):32,537
    Last modified:October 3, 2012 - v4
    Checksum:iCB8E31DABE8030FC
    GO

    Sequence cautioni

    The sequence AAL27000.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti96 – 961V → D in AAL89821. (PubMed:11861490)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF403014 Genomic DNA. Translation: AAL27000.1. Sequence problems.
    AY081843 mRNA. Translation: AAL89821.1.
    AL160282 Genomic DNA. No translation available.
    UniGeneiHs.356873.
    Hs.711567.

    Genome annotation databases

    EnsembliENST00000361928; ENSP00000354569; ENSG00000211451.
    UCSCiuc009wiv.3. human.

    Polymorphism databases

    DMDMi408360337.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF403014 Genomic DNA. Translation: AAL27000.1 . Sequence problems.
    AY081843 mRNA. Translation: AAL89821.1 .
    AL160282 Genomic DNA. No translation available.
    UniGenei Hs.356873.
    Hs.711567.

    3D structure databases

    ProteinModelPortali Q96P88.
    SMRi Q96P88. Positions 12-242.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000354569.

    Chemistry

    DrugBanki DB01406. Danazol.
    DB00644. Gonadorelin.
    DB00666. Nafarelin.
    GuidetoPHARMACOLOGYi 257.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q96P88.

    Polymorphism databases

    DMDMi 408360337.

    Proteomic databases

    PRIDEi Q96P88.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000361928 ; ENSP00000354569 ; ENSG00000211451 .
    UCSCi uc009wiv.3. human.

    Organism-specific databases

    GeneCardsi GC01M145509.
    HGNCi HGNC:16341. GNRHR2.
    MIMi 612875. gene.
    neXtProti NX_Q96P88.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG277514.
    HOVERGENi HBG107957.
    OrthoDBi EOG7SJD52.
    TreeFami TF106499.

    Enzyme and pathway databases

    Reactomei REACT_16942. Hormone ligand-binding receptors.
    REACT_18283. G alpha (q) signalling events.

    Miscellaneous databases

    PROi Q96P88.
    SOURCEi Search...

    Gene expression databases

    CleanExi HS_GNRHR2.
    Genevestigatori Q96P88.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR027983. GphnRH_2_rcpt.
    IPR001658. GphnRH_fam_rcpt.
    [Graphical view ]
    PANTHERi PTHR24241:SF66. PTHR24241:SF66. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00529. GNADOTRPHINR.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genes encoding the type II gonadotropin-releasing hormone receptor and the ribonucleoprotein RBM8A in humans overlap in two genomic loci."
      Faurholm B., Millar R.P., Katz A.A.
      Genomics 78:15-18(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Minireview: GnRH and GnRH receptor genes in the human genome."
      Neill J.D.
      Endocrinology 143:737-743(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
      Tissue: Testis.
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "A transcriptionally active human type II gonadotropin-releasing hormone receptor gene homolog overlaps two genes in the antisense orientation on chromosome 1q.12."
      Morgan K., Conklin D., Pawson A.J., Sellar R., Ott T.R., Millar R.P.
      Endocrinology 144:423-436(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    5. "Retention and silencing of prepro-GnRH-II and type II GnRH receptor genes in mammals."
      Stewart A.J., Katz A.A., Millar R.P., Morgan K.
      Neuroendocrinology 90:416-432(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiGNRR2_HUMAN
    AccessioniPrimary (citable) accession number: Q96P88
    Secondary accession number(s): E7EN27, Q8TCX8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 12, 2003
    Last sequence update: October 3, 2012
    Last modified: October 1, 2014
    This is version 113 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Could be the product of a pseudogene. A frameshift introducing a premature stop codon in exon 1 most probably results in the inactivation of that transcribed gene in human. However, alternative splicing may allow the production of a truncated but possibly functional protein containing 5 transmembrane domains which is shown here.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3