Q96P88 (GNRR2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative gonadotropin-releasing hormone II receptor
Short name=GnRH II receptor
Short name=GnRH-II-R

Alternative name(s):
Type II GnRH receptor

Gene names

Name:

GNRHR2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	178 AA.
Sequence status	Complete.
Protein existence	Uncertain

General annotation (Comments)

Function	Receptor for gonadotropin releasing hormone II (GnRH II). This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Expressed in many tissues. Ref.2
Post-translational modification	Phosphorylated on the C-terminal cytoplasmic tail Probable.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.
Caution	Could be the product of a pseudogene. This protein seems to be substantially shorter than orthologous proteins in related organisms.
Sequence caution	The sequence AAL27000.1 differs from that shown. Reason: Erroneous termination at position 179. Translated as stop. The sequence AAL27000.1 differs from that shown. Reason: Frameshift at position 9.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular function	gonadotropin-releasing hormone receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96P88-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96P88-2)

Also known as: GnRH-RII-5TM;

The sequence of this isoform differs from the canonical sequence as follows:
     10-96: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 178	178	Putative gonadotropin-releasing hormone II receptor		PRO_0000069497
Regions
	Topological domain	1 – 40	40	Extracellular Potential
	Transmembrane	41 – 61	21	Helical; Name=1; Potential
	Topological domain	62 – 77	16	Cytoplasmic Potential
	Transmembrane	78 – 98	21	Helical; Name=2; Potential
	Topological domain	99 – 115	17	Extracellular Potential
	Transmembrane	116 – 136	21	Helical; Name=3; Potential
	Topological domain	137 – 154	18	Cytoplasmic Potential
	Transmembrane	155 – 175	21	Helical; Name=4; Potential
	Topological domain	176 – 178	3	Extracellular Potential
Amino acid modifications
	Glycosylation	101	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	10 – 96	87	Missing in isoform 2.		VSP_001915

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 25, 2008. Version 3. Checksum: D2CBC7A7F3F48FBD	FASTA	178	19,031
	10 20 30 40 50 60 MSAGNGTPWG SAAGEEVWAG SGVEVEGSEL PTFSAAAKVR VGVTIVLFVS SAGGNLAVLW 70 80 90 100 110 120 SVTRREPSQL RPSPVRRLFI HLAAADLLVT FVVMPLDATW NITVQWLAVD IACRTLMFLK 130 140 150 160 170 LMATYSAAFL PVVIGLDRQA AVLNPLGSRS GVRKLLGAAW GLSFLLAFPQ LFLFHTVH
	Isoform 2 (GnRH-RII-5TM) [UniParc]. Checksum: 7190E83EC333914C	FASTA	91	9,947
	10 20 30 40 50 60 MSAGNGTPWD ATWNITVQWL AVDIACRTLM FLKLMATYSA AFLPVVIGLD RQAAVLNPLG 70 80 90 SRSGVRKLLG AAWGLSFLLA FPQLFLFHTV H

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genes encoding the type II gonadotropin-releasing hormone receptor and the ribonucleoprotein RBM8A in humans overlap in two genomic loci." Faurholm B., Millar R.P., Katz A.A. Genomics 78:15-18(2001) [PubMed: 11707068] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
[2]	"Minireview: GnRH and GnRH receptor genes in the human genome." Neill J.D. Endocrinology 143:737-743(2002) [PubMed: 11861490] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2), TISSUE SPECIFICITY. Tissue: Testis.
[3]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF403014 Genomic DNA. Translation: AAL27000.1. Sequence problems. AY081843 mRNA. Translation: AAL89821.1. AL160282 Genomic DNA. No translation available.
IPI	IPI00044315. IPI00216032.
UniGene	Hs.356873. Hs.711567.
3D structure databases
ProteinModelPortal	Q96P88.
SMR	Q96P88. Positions 41-176.
ModBase	Search...
Protein-protein interaction databases
STRING	Q96P88.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q96P88.
Polymorphism databases
DMDM	215274150.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
GeneCards	GC01M145509.
HGNC	HGNC:16341. GNRHR2.
MIM	612875. gene.
neXtProt	NX_Q96P88.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG107957.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	Q96P88.
CleanEx	HS_GNRHR2.
Genevestigator	Q96P88.
GermOnline	ENSG00000211451. Homo sapiens.
Family and domain databases
InterPro	IPR000276. 7TM_GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. IPR001658. GphnRH_rcpt. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00529. GNADOTRPHINR. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. False negative. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
DrugBank	DB01406. Danazol. DB00644. Gonadorelin. DB00666. Nafarelin.
SOURCE	Search...

Entry information

Entry name

GNRR2_HUMAN

Accession

Primary (citable) accession number: Q96P88
Secondary accession number(s): Q8TCX8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 12, 2003
Last sequence update:	November 25, 2008
Last modified:	January 25, 2012
This is version 92 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.