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Protein

Putative gonadotropin-releasing hormone II receptor

Gene

GNRHR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein uncertaini

Functioni

Putative receptor for gonadotropin releasing hormone II (GnRH II) which is most probably non-functional.2 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:G66-33775-MONOMER.
ReactomeiR-HSA-375281. Hormone ligand-binding receptors.
R-HSA-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative gonadotropin-releasing hormone II receptor
Short name:
GnRH II receptor
Short name:
GnRH-II-R
Alternative name(s):
Type II GnRH receptor
Gene namesi
Name:GNRHR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:16341. GNRHR2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 28ExtracellularSequence analysisAdd BLAST28
Transmembranei29 – 49Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini50 – 67CytoplasmicSequence analysisAdd BLAST18
Transmembranei68 – 88Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini89 – 115ExtracellularSequence analysisAdd BLAST27
Transmembranei116 – 136Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini137 – 177CytoplasmicSequence analysisAdd BLAST41
Transmembranei178 – 198Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini199 – 216ExtracellularSequence analysisAdd BLAST18
Transmembranei217 – 237Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini238 – 292CytoplasmicSequence analysisAdd BLAST55

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi114814.

Chemistry databases

DrugBankiDB01406. Danazol.
DB00644. Gonadorelin.
DB00666. Nafarelin.

Polymorphism and mutation databases

DMDMi408360337.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000694971 – 292Putative gonadotropin-releasing hormone II receptorAdd BLAST292

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi26 ↔ 101PROSITE-ProRule annotation

Post-translational modificationi

Phosphorylated on the C-terminal cytoplasmic tail.Curated

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiQ96P88.
PRIDEiQ96P88.

PTM databases

PhosphoSitePlusiQ96P88.

Expressioni

Tissue specificityi

Expressed in many tissues.1 Publication

Gene expression databases

CleanExiHS_GNRHR2.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000354569.

Structurei

3D structure databases

ProteinModelPortaliQ96P88.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOVERGENiHBG107957.
InParanoidiQ96P88.
TreeFamiTF106499.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR027983. GphnRH_2_rcpt.
IPR001658. GphnRH_fam_rcpt.
[Graphical view]
PANTHERiPTHR24241:SF69. PTHR24241:SF69. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00529. GNADOTRPHINR.
PR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96P88-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAGNGTPWD ATWNITVQWL AVDIACRTLM FLKLMATYSA AFLPVVIGLD
60 70 80 90 100
RQAAVLNPLG SRSGVRKLLG AAWGLSFLLA FPQLFLFHTV HCAGPVPFTQ
110 120 130 140 150
CVTKGSFKAQ WQETTYNLFT FCCLFLLPLT AMAICYSRIV LSVSRPQTRK
160 170 180 190 200
GSHAPAGEFA LPRSFDNCPR VRLRALRLAL LILLTFILCW TPYYLLGMWY
210 220 230 240 250
WFSPTMLTEV PPSLSHILFL LGLLNAPLDP LLYGAFTLGC RRGHQELSID
260 270 280 290
SSKEGSGRML QEEIHAFRQL EVQKTVTSRR AGETKGISIT SI
Length:292
Mass (Da):32,537
Last modified:October 3, 2012 - v4
Checksum:iCB8E31DABE8030FC
GO

Sequence cautioni

The sequence AAL27000 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti96V → D in AAL89821 (PubMed:11861490).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF403014 Genomic DNA. Translation: AAL27000.1. Sequence problems.
AY081843 mRNA. Translation: AAL89821.1.
AL160282 Genomic DNA. No translation available.
UniGeneiHs.356873.
Hs.711567.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF403014 Genomic DNA. Translation: AAL27000.1. Sequence problems.
AY081843 mRNA. Translation: AAL89821.1.
AL160282 Genomic DNA. No translation available.
UniGeneiHs.356873.
Hs.711567.

3D structure databases

ProteinModelPortaliQ96P88.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000354569.

Chemistry databases

DrugBankiDB01406. Danazol.
DB00644. Gonadorelin.
DB00666. Nafarelin.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ96P88.

Polymorphism and mutation databases

DMDMi408360337.

Proteomic databases

PaxDbiQ96P88.
PRIDEiQ96P88.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

DisGeNETi114814.
GeneCardsiGNRHR2.
HGNCiHGNC:16341. GNRHR2.
MIMi612875. gene.
neXtProtiNX_Q96P88.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOVERGENiHBG107957.
InParanoidiQ96P88.
TreeFamiTF106499.

Enzyme and pathway databases

BioCyciZFISH:G66-33775-MONOMER.
ReactomeiR-HSA-375281. Hormone ligand-binding receptors.
R-HSA-416476. G alpha (q) signalling events.

Miscellaneous databases

PROiQ96P88.
SOURCEiSearch...

Gene expression databases

CleanExiHS_GNRHR2.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR027983. GphnRH_2_rcpt.
IPR001658. GphnRH_fam_rcpt.
[Graphical view]
PANTHERiPTHR24241:SF69. PTHR24241:SF69. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00529. GNADOTRPHINR.
PR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGNRR2_HUMAN
AccessioniPrimary (citable) accession number: Q96P88
Secondary accession number(s): E7EN27, Q8TCX8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: October 3, 2012
Last modified: November 2, 2016
This is version 127 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene. A frameshift introducing a premature stop codon in exon 1 most probably results in the inactivation of that transcribed gene in human. However, alternative splicing may allow the production of a truncated but possibly functional protein containing 5 transmembrane domains which is shown here.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.