Q96P88 (GNRR2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative gonadotropin-releasing hormone II receptor
Short name=GnRH II receptor
Short name=GnRH-II-R

Alternative name(s):
Type II GnRH receptor

Gene names

Name:

GNRHR2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	292 AA.
Sequence status	Complete.
Protein existence	Uncertain

General annotation (Comments)

Function	Putative receptor for gonadotropin releasing hormone II (GnRH II) which is most probably non-functional. Ref.4 Ref.5
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Expressed in many tissues. Ref.2
Post-translational modification	Phosphorylated on the C-terminal cytoplasmic tail Probable.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.
Caution	Could be the product of a pseudogene. A frameshift introducing a premature stop codon in exon 1 most probably results in the inactivation of that transcribed gene in human. However, alternative splicing may allow the production of a truncated but possibly functional protein containing 5 transmembrane domains which is shown here.
Sequence caution	The sequence AAL27000.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular response to gonadotropin-releasing hormone Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular_function	gonadotropin-releasing hormone receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 292	292	Putative gonadotropin-releasing hormone II receptor		PRO_0000069497
Regions
	Topological domain	1 – 28	28	Extracellular Potential
	Transmembrane	29 – 49	21	Helical; Name=1; Potential
	Topological domain	50 – 67	18	Cytoplasmic Potential
	Transmembrane	68 – 88	21	Helical; Name=2; Potential
	Topological domain	89 – 115	27	Extracellular Potential
	Transmembrane	116 – 136	21	Helical; Name=3; Potential
	Topological domain	137 – 177	41	Cytoplasmic Potential
	Transmembrane	178 – 198	21	Helical; Name=4; Potential
	Topological domain	199 – 216	18	Extracellular Potential
	Transmembrane	217 – 237	21	Helical; Name=5; Potential
	Topological domain	238 – 292	55	Cytoplasmic Potential
Amino acid modifications
	Disulfide bond	26 ↔ 101		By similarity
Experimental info
	Sequence conflict	96	1	V → D in AAL89821. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q96P88 [UniParc]. Last modified October 3, 2012. Version 4. Checksum: CB8E31DABE8030FC	FASTA	292	32,537
	10 20 30 40 50 60 MSAGNGTPWD ATWNITVQWL AVDIACRTLM FLKLMATYSA AFLPVVIGLD RQAAVLNPLG 70 80 90 100 110 120 SRSGVRKLLG AAWGLSFLLA FPQLFLFHTV HCAGPVPFTQ CVTKGSFKAQ WQETTYNLFT 130 140 150 160 170 180 FCCLFLLPLT AMAICYSRIV LSVSRPQTRK GSHAPAGEFA LPRSFDNCPR VRLRALRLAL 190 200 210 220 230 240 LILLTFILCW TPYYLLGMWY WFSPTMLTEV PPSLSHILFL LGLLNAPLDP LLYGAFTLGC 250 260 270 280 290 RRGHQELSID SSKEGSGRML QEEIHAFRQL EVQKTVTSRR AGETKGISIT SI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genes encoding the type II gonadotropin-releasing hormone receptor and the ribonucleoprotein RBM8A in humans overlap in two genomic loci." Faurholm B., Millar R.P., Katz A.A. Genomics 78:15-18(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Minireview: GnRH and GnRH receptor genes in the human genome." Neill J.D. Endocrinology 143:737-743(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY. Tissue: Testis.
[3]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"A transcriptionally active human type II gonadotropin-releasing hormone receptor gene homolog overlaps two genes in the antisense orientation on chromosome 1q.12." Morgan K., Conklin D., Pawson A.J., Sellar R., Ott T.R., Millar R.P. Endocrinology 144:423-436(2003) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[5]	"Retention and silencing of prepro-GnRH-II and type II GnRH receptor genes in mammals." Stewart A.J., Katz A.A., Millar R.P., Morgan K. Neuroendocrinology 90:416-432(2009) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF403014 Genomic DNA. Translation: AAL27000.1. Sequence problems. AY081843 mRNA. Translation: AAL89821.1. AL160282 Genomic DNA. No translation available.
IPI	IPI00044315. IPI00216032.
UniGene	Hs.356873. Hs.711567.
3D structure databases
ProteinModelPortal	Q96P88.
SMR	Q96P88. Positions 12-234.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000354569.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q96P88.
Polymorphism databases
DMDM	215274150.
Proteomic databases
PRIDE	Q96P88.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000361928; ENSP00000354569; ENSG00000211451.
Organism-specific databases
GeneCards	GC01M145509.
HGNC	HGNC:16341. GNRHR2.
MIM	612875. gene.
neXtProt	NX_Q96P88.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG277514.
HOVERGEN	HBG107957.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
CleanEx	HS_GNRHR2.
Genevestigator	Q96P88.
GermOnline	ENSG00000211451. Homo sapiens.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR001658. GphnRH_rcpt. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00529. GNADOTRPHINR. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. False negative. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
DrugBank	DB01406. Danazol. DB00644. Gonadorelin. DB00666. Nafarelin.
SOURCE	Search...

Entry information

Entry name

GNRR2_HUMAN

Accession

Primary (citable) accession number: Q96P88
Secondary accession number(s): E7EN27, Q8TCX8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 12, 2003
Last sequence update:	October 3, 2012
Last modified:	May 1, 2013
This is version 101 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.