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Q96P88

- GNRR2_HUMAN

UniProt

Q96P88 - GNRR2_HUMAN

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Protein

Putative gonadotropin-releasing hormone II receptor

Gene
GNRHR2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Protein uncertaini

Functioni

Putative receptor for gonadotropin releasing hormone II (GnRH II) which is most probably non-functional.2 Publications

GO - Molecular functioni

  1. gonadotropin-releasing hormone receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_16942. Hormone ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative gonadotropin-releasing hormone II receptor
Short name:
GnRH II receptor
Short name:
GnRH-II-R
Alternative name(s):
Type II GnRH receptor
Gene namesi
Name:GNRHR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:16341. GNRHR2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2828Extracellular Reviewed predictionAdd
BLAST
Transmembranei29 – 4921Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini50 – 6718Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei68 – 8821Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini89 – 11527Extracellular Reviewed predictionAdd
BLAST
Transmembranei116 – 13621Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini137 – 17741Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei178 – 19821Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini199 – 21618Extracellular Reviewed predictionAdd
BLAST
Transmembranei217 – 23721Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini238 – 29255Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 292292Putative gonadotropin-releasing hormone II receptorPRO_0000069497Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi26 ↔ 101 By similarity

Post-translational modificationi

Phosphorylated on the C-terminal cytoplasmic tail Inferred.

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PRIDEiQ96P88.

PTM databases

PhosphoSiteiQ96P88.

Expressioni

Tissue specificityi

Expressed in many tissues.1 Publication

Gene expression databases

CleanExiHS_GNRHR2.
GenevestigatoriQ96P88.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000354569.

Structurei

3D structure databases

ProteinModelPortaliQ96P88.
SMRiQ96P88. Positions 12-242.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG277514.
HOVERGENiHBG107957.
OrthoDBiEOG7SJD52.
TreeFamiTF106499.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR027983. GphnRH_2_rcpt.
IPR001658. GphnRH_fam_rcpt.
[Graphical view]
PANTHERiPTHR24241:SF66. PTHR24241:SF66. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00529. GNADOTRPHINR.
PR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96P88-1 [UniParc]FASTAAdd to Basket

« Hide

MSAGNGTPWD ATWNITVQWL AVDIACRTLM FLKLMATYSA AFLPVVIGLD    50
RQAAVLNPLG SRSGVRKLLG AAWGLSFLLA FPQLFLFHTV HCAGPVPFTQ 100
CVTKGSFKAQ WQETTYNLFT FCCLFLLPLT AMAICYSRIV LSVSRPQTRK 150
GSHAPAGEFA LPRSFDNCPR VRLRALRLAL LILLTFILCW TPYYLLGMWY 200
WFSPTMLTEV PPSLSHILFL LGLLNAPLDP LLYGAFTLGC RRGHQELSID 250
SSKEGSGRML QEEIHAFRQL EVQKTVTSRR AGETKGISIT SI 292
Length:292
Mass (Da):32,537
Last modified:October 3, 2012 - v4
Checksum:iCB8E31DABE8030FC
GO

Sequence cautioni

The sequence AAL27000.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti96 – 961V → D in AAL89821. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF403014 Genomic DNA. Translation: AAL27000.1. Sequence problems.
AY081843 mRNA. Translation: AAL89821.1.
AL160282 Genomic DNA. No translation available.
UniGeneiHs.356873.
Hs.711567.

Genome annotation databases

EnsembliENST00000361928; ENSP00000354569; ENSG00000211451.
UCSCiuc009wiv.3. human.

Polymorphism databases

DMDMi408360337.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF403014 Genomic DNA. Translation: AAL27000.1 . Sequence problems.
AY081843 mRNA. Translation: AAL89821.1 .
AL160282 Genomic DNA. No translation available.
UniGenei Hs.356873.
Hs.711567.

3D structure databases

ProteinModelPortali Q96P88.
SMRi Q96P88. Positions 12-242.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000354569.

Chemistry

DrugBanki DB01406. Danazol.
DB00644. Gonadorelin.
DB00666. Nafarelin.
GuidetoPHARMACOLOGYi 257.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q96P88.

Polymorphism databases

DMDMi 408360337.

Proteomic databases

PRIDEi Q96P88.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000361928 ; ENSP00000354569 ; ENSG00000211451 .
UCSCi uc009wiv.3. human.

Organism-specific databases

GeneCardsi GC01M145509.
HGNCi HGNC:16341. GNRHR2.
MIMi 612875. gene.
neXtProti NX_Q96P88.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG277514.
HOVERGENi HBG107957.
OrthoDBi EOG7SJD52.
TreeFami TF106499.

Enzyme and pathway databases

Reactomei REACT_16942. Hormone ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.

Miscellaneous databases

PROi Q96P88.
SOURCEi Search...

Gene expression databases

CleanExi HS_GNRHR2.
Genevestigatori Q96P88.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR027983. GphnRH_2_rcpt.
IPR001658. GphnRH_fam_rcpt.
[Graphical view ]
PANTHERi PTHR24241:SF66. PTHR24241:SF66. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00529. GNADOTRPHINR.
PR00237. GPCRRHODOPSN.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genes encoding the type II gonadotropin-releasing hormone receptor and the ribonucleoprotein RBM8A in humans overlap in two genomic loci."
    Faurholm B., Millar R.P., Katz A.A.
    Genomics 78:15-18(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Minireview: GnRH and GnRH receptor genes in the human genome."
    Neill J.D.
    Endocrinology 143:737-743(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
    Tissue: Testis.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "A transcriptionally active human type II gonadotropin-releasing hormone receptor gene homolog overlaps two genes in the antisense orientation on chromosome 1q.12."
    Morgan K., Conklin D., Pawson A.J., Sellar R., Ott T.R., Millar R.P.
    Endocrinology 144:423-436(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "Retention and silencing of prepro-GnRH-II and type II GnRH receptor genes in mammals."
    Stewart A.J., Katz A.A., Millar R.P., Morgan K.
    Neuroendocrinology 90:416-432(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiGNRR2_HUMAN
AccessioniPrimary (citable) accession number: Q96P88
Secondary accession number(s): E7EN27, Q8TCX8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: October 3, 2012
Last modified: September 3, 2014
This is version 112 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene. A frameshift introducing a premature stop codon in exon 1 most probably results in the inactivation of that transcribed gene in human. However, alternative splicing may allow the production of a truncated but possibly functional protein containing 5 transmembrane domains which is shown here.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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