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Protein

Importin-9

Gene

IPO9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of H2B histone (By similarity), RPS7 and RPL18A. Prevents the cytoplasmic aggregation of RPS7 and RPL18A by shielding exposed basic domains. May also import H2A, H3, H4 histones (By similarity), RPL4 and RPL6.By similarity1 Publication

GO - Molecular functioni

  • histone binding Source: UniProtKB
  • protein transporter activity Source: UniProtKB
  • Ran GTPase binding Source: InterPro

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Protein family/group databases

TCDBi1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Importin-9
Short name:
Imp9
Alternative name(s):
Ran-binding protein 9
Short name:
RanBP9
Gene namesi
Name:IPO9
Synonyms:IMP9, KIAA1192, RANBP9
ORF Names:HSPC273
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000198700.9
HGNCiHGNC:19425 IPO9
neXtProtiNX_Q96P70

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi55705
OpenTargetsiENSG00000198700
PharmGKBiPA134930111

Polymorphism and mutation databases

BioMutaiIPO9
DMDMi41688593

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00001207542 – 1041Importin-9Add BLAST1040

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ96P70
MaxQBiQ96P70
PaxDbiQ96P70
PeptideAtlasiQ96P70
PRIDEiQ96P70

PTM databases

iPTMnetiQ96P70
PhosphoSitePlusiQ96P70
SwissPalmiQ96P70

Expressioni

Gene expression databases

BgeeiENSG00000198700
CleanExiHS_IPO9
HS_RANBP9
ExpressionAtlasiQ96P70 baseline and differential
GenevisibleiQ96P70 HS

Organism-specific databases

HPAiHPA059540

Interactioni

Subunit structurei

Binds with high affinity to RPS7 and RPL18A. The binding is coupled to RanGTP cycles. May bind H2A, H3, H4 histones (By similarity), RPL4 and RPL6 with low affinity. Interacts with PPP2R1A and PPP2R1B.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
MYCP011062EBI-356319,EBI-447544

GO - Molecular functioni

Protein-protein interaction databases

BioGridi12083091 interactors.
IntActiQ96P70 27 interactors.
MINTiQ96P70
STRINGi9606.ENSP00000354742

Structurei

3D structure databases

ProteinModelPortaliQ96P70
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 119Importin N-terminalPROSITE-ProRule annotationAdd BLAST77

Sequence similaritiesi

Belongs to the importin beta family.Curated

Phylogenomic databases

eggNOGiKOG2274 Eukaryota
COG5657 LUCA
GeneTreeiENSGT00390000008224
HOVERGENiHBG049054
InParanoidiQ96P70
KOiK20224
OMAiTMALCKL
OrthoDBiEOG091G01DL
PhylomeDBiQ96P70
TreeFamiTF323706

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR001494 Importin-beta_N
PfamiView protein in Pfam
PF03810 IBN_N, 1 hit
SMARTiView protein in SMART
SM00913 IBN_N, 1 hit
SUPFAMiSSF48371 SSF48371, 2 hits
PROSITEiView protein in PROSITE
PS50166 IMPORTIN_B_NT, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96P70-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAAAAGAA SGLPGPVAQG LKEALVDTLT GILSPVQEVR AAAEEQIKVL
60 70 80 90 100
EVTEEFGVHL AELTVDPQGA LAIRQLASVI LKQYVETHWC AQSEKFRPPE
110 120 130 140 150
TTERAKIVIR ELLPNGLRES ISKVRSSVAY AVSAIAHWDW PEAWPQLFNL
160 170 180 190 200
LMEMLVSGDL NAVHGAMRVL TEFTREVTDT QMPLVAPVIL PEMYKIFTMA
210 220 230 240 250
EVYGIRTRSR AVEIFTTCAH MICNMEELEK GAAKVLIFPV VQQFTEAFVQ
260 270 280 290 300
ALQIPDGPTS DSGFKMEVLK AVTALVKNFP KHMVSSMQQI LPIVWNTLTE
310 320 330 340 350
SAAFYVRTEV NYTEEVEDPV DSDGEVLGFE NLVFSIFEFV HALLENSKFK
360 370 380 390 400
STVKKALPEL IYYIILYMQI TEEQIKVWTA NPQQFVEDED DDTFSYTVRI
410 420 430 440 450
AAQDLLLAVA TDFQNESAAA LAAAATRHLQ EAEQTKNSGT EHWWKIHEAC
460 470 480 490 500
MLALGSVKAI ITDSVKNGRI HFDMHGFLTN VILADLNLSV SPFLLGRALW
510 520 530 540 550
AASRFTVAMS PELIQQFLQA TVSGLHETQP PSVRISAVRA IWGYCDQLKV
560 570 580 590 600
SESTHVLQPF LPSILDGLIH LAAQFSSEVL NLVMETLCIV CTVDPEFTAS
610 620 630 640 650
MESKICPFTI AIFLKYSNDP VVASLAQDIF KELSQIEACQ GPMQMRLIPT
660 670 680 690 700
LVSIMQAPAD KIPAGLCATA IDILTTVVRN TKPPLSQLLI CQAFPAVAQC
710 720 730 740 750
TLHTDDNATM QNGGECLRAY VSVTLEQVAQ WHDEQGHNGL WYVMQVVSQL
760 770 780 790 800
LDPRTSEFTA AFVGRLVSTL ISKAGRELGE NLDQILRAIL SKMQQAETLS
810 820 830 840 850
VMQSLIMVFA HLVHTQLEPL LEFLCSLPGP TGKPALEFVM AEWTSRQHLF
860 870 880 890 900
YGQYEGKVSS VALCKLLQHG INADDKRLQD IRVKGEEIYS MDEGIRTRSK
910 920 930 940 950
SAKNPERWTN IPLLVKILKL IINELSNVME ANAARQATPA EWSQDDSNDM
960 970 980 990 1000
WEDQEEEEEE EEDGLAGQLL SDILATSKYE EDYYEDDEED DPDALKDPLY
1010 1020 1030 1040
QIDLQAYLTD FLCQFAQQPC YIMFSGHLND NERRVLQTIG I
Length:1,041
Mass (Da):115,963
Last modified:January 23, 2007 - v3
Checksum:iA1842C357AEDFD90
GO

Sequence cautioni

The sequence AAF28951 differs from that shown. Reason: Frameshift at position 982.Curated
The sequence BAA86506 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA91588 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB55181 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC11173 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti632E → G in BAC11173 (PubMed:14702039).Curated1
Sequence conflicti916K → R in BAC11173 (PubMed:14702039).Curated1
Sequence conflicti935R → P in BAB55181 (PubMed:14702039).Curated1
Sequence conflicti960E → G in BAC11173 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF410465 mRNA Translation: AAL01416.1
AL645504 Genomic DNA No translation available.
AK001264 mRNA Translation: BAA91588.1 Different initiation.
AK027532 mRNA Translation: BAB55181.1 Different initiation.
AK074740 mRNA Translation: BAC11173.1 Different initiation.
AK094603 mRNA Translation: BAC04383.1 Sequence problems.
CH471067 Genomic DNA Translation: EAW91376.1
BC003604 mRNA Translation: AAH03604.2
AF161391 mRNA Translation: AAF28951.1 Frameshift.
AL834323 mRNA Translation: CAD38991.1
AB033018 mRNA Translation: BAA86506.1 Different initiation.
CCDSiCCDS1415.1
RefSeqiNP_060555.2, NM_018085.4
UniGeneiHs.596014

Genome annotation databases

EnsembliENST00000361565; ENSP00000354742; ENSG00000198700
GeneIDi55705
KEGGihsa:55705
UCSCiuc001gwz.4 human

Similar proteinsi

Entry informationi

Entry nameiIPO9_HUMAN
AccessioniPrimary (citable) accession number: Q96P70
Secondary accession number(s): B1ASV5
, Q8N1Y1, Q8N3I2, Q8NCG9, Q96SU6, Q9NW01, Q9P0A8, Q9ULM8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: January 23, 2007
Last modified: April 25, 2018
This is version 152 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome