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Protein

G-protein coupled receptor 78

Gene

GPR78

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP.1 Publication

GO - Molecular functioni

  • G-protein coupled receptor activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 78
Gene namesi
Name:GPR78
ORF Names:UNQ5925/PRO19818
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:4528. GPR78.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 77ExtracellularSequence analysis
Transmembranei8 – 2821Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini29 – 4719CytoplasmicSequence analysisAdd
BLAST
Transmembranei48 – 6821Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini69 – 8012ExtracellularSequence analysisAdd
BLAST
Transmembranei81 – 10121Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini102 – 12221CytoplasmicSequence analysisAdd
BLAST
Transmembranei123 – 14321Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini144 – 16825ExtracellularSequence analysisAdd
BLAST
Transmembranei169 – 18921Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini190 – 24253CytoplasmicSequence analysisAdd
BLAST
Transmembranei243 – 26321Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini264 – 27714ExtracellularSequence analysisAdd
BLAST
Transmembranei278 – 29720Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini298 – 36366CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi236 – 2361R → E: No effect on constitutive activity. 1 Publication

Organism-specific databases

PharmGKBiPA28921.

Polymorphism and mutation databases

BioMutaiGPR78.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 363363G-protein coupled receptor 78PRO_0000069585Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi79 ↔ 156PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ96P69.
PRIDEiQ96P69.

PTM databases

iPTMnetiQ96P69.

Expressioni

Tissue specificityi

High level of expression in placenta. Expressed throughout the brain at low level. No expression detected in skeletal muscle, lung, heart, liver, pancreas, or kidney.1 Publication

Gene expression databases

BgeeiQ96P69.
CleanExiHS_GPR78.
ExpressionAtlasiQ96P69. baseline and differential.
GenevisibleiQ96P69. HS.

Organism-specific databases

HPAiHPA013209.

Interactioni

Protein-protein interaction databases

BioGridi118076. 1 interaction.
STRINGi9606.ENSP00000371927.

Structurei

3D structure databases

ProteinModelPortaliQ96P69.
SMRiQ96P69. Positions 6-305.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00390000005107.
HOGENOMiHOG000059564.
HOVERGENiHBG051804.
InParanoidiQ96P69.
KOiK08418.
OMAiALSADQW.
PhylomeDBiQ96P69.
TreeFamiTF332434.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96P69-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPGEALLAG LLVMVLAVAL LSNALVLLCC AYSAELRTRA SGVLLVNLSL
60 70 80 90 100
GHLLLAALDM PFTLLGVMRG RTPSAPGACQ VIGFLDTFLA SNAALSVAAL
110 120 130 140 150
SADQWLAVGF PLRYAGRLRP RYAGLLLGCA WGQSLAFSGA ALGCSWLGYS
160 170 180 190 200
SAFASCSLRL PPEPERPRFA AFTATLHAVG FVLPLAVLCL TSLQVHRVAR
210 220 230 240 250
RHCQRMDTVT MKALALLADL HPSVRQRCLI QQKRRRHRAT RKIGIAIATF
260 270 280 290 300
LICFAPYVMT RLAELVPFVT VNAQWGILSK CLTYSKAVAD PFTYSLLRRP
310 320 330 340 350
FRQVLAGMVH RLLKRTPRPA STHDSSLDVA GMVHQLLKRT PRPASTHNGS
360
VDTENDSCLQ QTH
Length:363
Mass (Da):39,332
Last modified:April 13, 2004 - v2
Checksum:i2C0052A0A1A22A93
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti216 – 2161L → V in AAL26479 (PubMed:11574155).Curated
Sequence conflicti226 – 2272QR → HG in AAL26479 (PubMed:11574155).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti201 – 2011R → S.
Corresponds to variant rs17844778 [ dbSNP | Ensembl ].
VAR_024258
Natural varianti330 – 3301A → T.
Corresponds to variant rs11941659 [ dbSNP | Ensembl ].
VAR_033474
Natural varianti342 – 3421R → H.
Corresponds to variant rs9685931 [ dbSNP | Ensembl ].
VAR_033475

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF411107 mRNA. Translation: AAL26479.1.
AB065673 Genomic DNA. Translation: BAC05898.1.
AY359107 mRNA. Translation: AAQ89465.1.
BC057778 mRNA. Translation: AAH57778.1.
BC069343 mRNA. Translation: AAH69343.1.
BC069813 mRNA. Translation: AAH69813.1.
CCDSiCCDS3403.1.
RefSeqiNP_543009.2. NM_080819.4.
UniGeneiHs.740355.

Genome annotation databases

EnsembliENST00000382487; ENSP00000371927; ENSG00000155269.
GeneIDi27201.
KEGGihsa:27201.
UCSCiuc003glk.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF411107 mRNA. Translation: AAL26479.1.
AB065673 Genomic DNA. Translation: BAC05898.1.
AY359107 mRNA. Translation: AAQ89465.1.
BC057778 mRNA. Translation: AAH57778.1.
BC069343 mRNA. Translation: AAH69343.1.
BC069813 mRNA. Translation: AAH69813.1.
CCDSiCCDS3403.1.
RefSeqiNP_543009.2. NM_080819.4.
UniGeneiHs.740355.

3D structure databases

ProteinModelPortaliQ96P69.
SMRiQ96P69. Positions 6-305.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118076. 1 interaction.
STRINGi9606.ENSP00000371927.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ96P69.

Polymorphism and mutation databases

BioMutaiGPR78.

Proteomic databases

PaxDbiQ96P69.
PRIDEiQ96P69.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000382487; ENSP00000371927; ENSG00000155269.
GeneIDi27201.
KEGGihsa:27201.
UCSCiuc003glk.5. human.

Organism-specific databases

CTDi27201.
GeneCardsiGPR78.
HGNCiHGNC:4528. GPR78.
HPAiHPA013209.
MIMi606921. gene.
neXtProtiNX_Q96P69.
PharmGKBiPA28921.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00390000005107.
HOGENOMiHOG000059564.
HOVERGENiHBG051804.
InParanoidiQ96P69.
KOiK08418.
OMAiALSADQW.
PhylomeDBiQ96P69.
TreeFamiTF332434.

Miscellaneous databases

GeneWikiiGPR78.
GenomeRNAii27201.
PROiQ96P69.
SOURCEiSearch...

Gene expression databases

BgeeiQ96P69.
CleanExiHS_GPR78.
ExpressionAtlasiQ96P69. baseline and differential.
GenevisibleiQ96P69. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Discovery and mapping of ten novel G protein-coupled receptor genes."
    Lee D.K., Nguyen T., Lynch K.R., Cheng R., Vanti W.B., Arkhitko O., Lewis T., Evans J.F., George S.R., O'Dowd B.F.
    Gene 275:83-91(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Tissue distribution and functional analyses of the constitutively active orphan G protein coupled receptors, GPR26 and GPR78."
    Jones P.G., Nawoschik S.P., Sreekumar K., Uveges A.J., Tseng E., Zhang L., Johnson J., He L., Paulsen J.E., Bates B., Pausch M.H.
    Biochim. Biophys. Acta 1770:890-901(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, MUTAGENESIS OF ARG-236.

Entry informationi

Entry nameiGPR78_HUMAN
AccessioniPrimary (citable) accession number: Q96P69
Secondary accession number(s): Q8NGV3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: April 13, 2004
Last modified: June 8, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.