Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q96P68

- OXGR1_HUMAN

UniProt

Q96P68 - OXGR1_HUMAN

Protein

2-oxoglutarate receptor 1

Gene

OXGR1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Receptor for alpha-ketoglutarate. Seems to act exclusively through a G(q)-mediated pathway By similarity.By similarity

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW

    GO - Biological processi

    1. G-protein coupled receptor signaling pathway Source: UniProtKB

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_14828. Class A/1 (Rhodopsin-like receptors).
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    2-oxoglutarate receptor 1
    Alternative name(s):
    Alpha-ketoglutarate receptor 1
    G-protein coupled receptor 80
    G-protein coupled receptor 99
    P2Y purinoceptor 15
    Short name:
    P2Y15
    P2Y-like GPCR
    P2Y-like nucleotide receptor
    Gene namesi
    Name:OXGR1
    Synonyms:GPR80, GPR99, P2RY15, P2Y15
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 13

    Organism-specific databases

    HGNCiHGNC:4531. OXGR1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28924.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 3373372-oxoglutarate receptor 1PRO_0000069994Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi10 – 101N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi23 – 231N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi106 ↔ 183PROSITE-ProRule annotation
    Glycosylationi176 – 1761N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi179 – 1791N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ96P68.

    Expressioni

    Tissue specificityi

    Detected in kidney and, to a lower extend, in placenta. Not detected in brain tissues including the frontal cortex, caudate putamen, thalamus, hypothalamus, hippocampus or pons.

    Gene expression databases

    ArrayExpressiQ96P68.
    BgeeiQ96P68.
    CleanExiHS_OXGR1.
    GenevestigatoriQ96P68.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000298440.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96P68.
    SMRiQ96P68. Positions 24-312.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3434ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini56 – 6914CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini91 – 11626ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini138 – 15114CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini173 – 20129ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini223 – 24220CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini264 – 28421ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini306 – 33732CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei35 – 5521Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei70 – 9021Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei117 – 13721Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei152 – 17221Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei202 – 22221Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei243 – 26321Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei285 – 30521Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG146579.
    HOGENOMiHOG000231307.
    HOVERGENiHBG106870.
    InParanoidiQ96P68.
    KOiK08419.
    OMAiGFHFNLY.
    OrthoDBiEOG7Z95MM.
    PhylomeDBiQ96P68.
    TreeFamiTF330775.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96P68-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNEPLDYLAN ASDFPDYAAA FGNCTDENIP LKMHYLPVIY GIIFLVGFPG    50
    NAVVISTYIF KMRPWKSSTI IMLNLACTDL LYLTSLPFLI HYYASGENWI 100
    FGDFMCKFIR FSFHFNLYSS ILFLTCFSIF RYCVIIHPMS CFSIHKTRCA 150
    VVACAVVWII SLVAVIPMTF LITSTNRTNR SACLDLTSSD ELNTIKWYNL 200
    ILTATTFCLP LVIVTLCYTT IIHTLTHGLQ TDSCLKQKAR RLTILLLLAF 250
    YVCFLPFHIL RVIRIESRLL SISCSIENQI HEAYIVSRPL AALNTFGNLL 300
    LYVVVSDNFQ QAVCSTVRCK VSGNLEQAKK ISYSNNP 337
    Length:337
    Mass (Da):38,251
    Last modified:December 1, 2001 - v1
    Checksum:i6814EA0044756CE6
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti14 – 141F → L in CAC83857. 1 PublicationCurated
    Sequence conflicti236 – 2361K → R in CAC83857. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF411109 Genomic DNA. Translation: AAL26480.1.
    AF370886 mRNA. Translation: AAM76912.1.
    AB083598 Genomic DNA. Translation: BAB89311.1.
    AB065877 Genomic DNA. Translation: BAC06095.1.
    AJ305372 mRNA. Translation: CAC83857.1.
    AL356486 Genomic DNA. Translation: CAI16508.1.
    BC103881 mRNA. Translation: AAI03882.1.
    BC103882 mRNA. Translation: AAI03883.1.
    BC103883 mRNA. Translation: AAI03884.1.
    CCDSiCCDS9482.1.
    RefSeqiNP_543008.3. NM_080818.3.
    XP_005254100.1. XM_005254043.1.
    XP_005254101.1. XM_005254044.1.
    XP_005254102.1. XM_005254045.1.
    XP_005254103.1. XM_005254046.1.
    UniGeneiHs.352218.

    Genome annotation databases

    EnsembliENST00000298440; ENSP00000298440; ENSG00000165621.
    ENST00000543457; ENSP00000438800; ENSG00000165621.
    GeneIDi27199.
    KEGGihsa:27199.
    UCSCiuc001vmx.1. human.

    Polymorphism databases

    DMDMi48474598.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF411109 Genomic DNA. Translation: AAL26480.1 .
    AF370886 mRNA. Translation: AAM76912.1 .
    AB083598 Genomic DNA. Translation: BAB89311.1 .
    AB065877 Genomic DNA. Translation: BAC06095.1 .
    AJ305372 mRNA. Translation: CAC83857.1 .
    AL356486 Genomic DNA. Translation: CAI16508.1 .
    BC103881 mRNA. Translation: AAI03882.1 .
    BC103882 mRNA. Translation: AAI03883.1 .
    BC103883 mRNA. Translation: AAI03884.1 .
    CCDSi CCDS9482.1.
    RefSeqi NP_543008.3. NM_080818.3.
    XP_005254100.1. XM_005254043.1.
    XP_005254101.1. XM_005254044.1.
    XP_005254102.1. XM_005254045.1.
    XP_005254103.1. XM_005254046.1.
    UniGenei Hs.352218.

    3D structure databases

    ProteinModelPortali Q96P68.
    SMRi Q96P68. Positions 24-312.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000298440.

    Chemistry

    ChEMBLi CHEMBL2150840.
    GuidetoPHARMACOLOGYi 162.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 48474598.

    Proteomic databases

    PRIDEi Q96P68.

    Protocols and materials databases

    DNASUi 27199.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000298440 ; ENSP00000298440 ; ENSG00000165621 .
    ENST00000543457 ; ENSP00000438800 ; ENSG00000165621 .
    GeneIDi 27199.
    KEGGi hsa:27199.
    UCSCi uc001vmx.1. human.

    Organism-specific databases

    CTDi 27199.
    GeneCardsi GC13M097637.
    HGNCi HGNC:4531. OXGR1.
    MIMi 606922. gene.
    neXtProti NX_Q96P68.
    PharmGKBi PA28924.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG146579.
    HOGENOMi HOG000231307.
    HOVERGENi HBG106870.
    InParanoidi Q96P68.
    KOi K08419.
    OMAi GFHFNLY.
    OrthoDBi EOG7Z95MM.
    PhylomeDBi Q96P68.
    TreeFami TF330775.

    Enzyme and pathway databases

    Reactomei REACT_14828. Class A/1 (Rhodopsin-like receptors).
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    GeneWikii OXGR1.
    GenomeRNAii 27199.
    NextBioi 50066.
    PROi Q96P68.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96P68.
    Bgeei Q96P68.
    CleanExi HS_OXGR1.
    Genevestigatori Q96P68.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Discovery and mapping of ten novel G protein-coupled receptor genes."
      Lee D.K., Nguyen T., Lynch K.R., Cheng R., Vanti W.B., Arkhitko O., Lewis T., Evans J.F., George S.R., O'Dowd B.F.
      Gene 275:83-91(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "GPR99, a new G protein-coupled receptor with homology to a new subgroup of nucleotide receptors."
      Wittenberger T., Hellebrand S., Munck A., Kreienkamp H.-J., Schaller H.C., Hampe W.
      BMC Genomics 3:17-17(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Placenta.
    3. "Identification of G protein-coupled receptor genes from the human genome sequence."
      Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.
      FEBS Lett. 520:97-101(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    5. "Molecular cloning and functional characterization of a new human P2Y receptor."
      Bruess M., Bonisch H., von Kugelgen I.
      Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Thyroid.
    6. "The DNA sequence and analysis of human chromosome 13."
      Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
      Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiOXGR1_HUMAN
    AccessioniPrimary (citable) accession number: Q96P68
    Secondary accession number(s): Q5T5A7, Q86TL1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Was originally (PubMed:15057823) thought to be a P2Y receptor.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 13
      Human chromosome 13: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3