Q96P68 (OXGR1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
2-oxoglutarate receptor 1

Alternative name(s):
Alpha-ketoglutarate receptor 1
G-protein coupled receptor 80
G-protein coupled receptor 99
P2Y purinoceptor 15
Short name=P2Y15
P2Y-like GPCR
P2Y-like nucleotide receptor

Gene names

Name:	OXGR1
Synonyms:	GPR80, GPR99, P2RY15, P2Y15

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	337 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for alpha-ketoglutarate. Seems to act exclusively through a G(q)-mediated pathway By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Detected in kidney and, to a lower extend, in placenta. Not detected in brain tissues including the frontal cortex, caudate putamen, thalamus, hypothalamus, hippocampus or pons.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.
Caution	Was originally (Ref.5) thought to be a P2Y receptor.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	G-protein coupled receptor signaling pathway Traceable author statement Ref.2. Source: UniProtKB
Cellular_component	integral to membrane Traceable author statement Ref.2. Source: UniProtKB plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	G-protein coupled purinergic nucleotide receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 337	337	2-oxoglutarate receptor 1		PRO_0000069994
Regions
	Topological domain	1 – 34	34	Extracellular Potential
	Transmembrane	35 – 55	21	Helical; Name=1; Potential
	Topological domain	56 – 69	14	Cytoplasmic Potential
	Transmembrane	70 – 90	21	Helical; Name=2; Potential
	Topological domain	91 – 116	26	Extracellular Potential
	Transmembrane	117 – 137	21	Helical; Name=3; Potential
	Topological domain	138 – 151	14	Cytoplasmic Potential
	Transmembrane	152 – 172	21	Helical; Name=4; Potential
	Topological domain	173 – 201	29	Extracellular Potential
	Transmembrane	202 – 222	21	Helical; Name=5; Potential
	Topological domain	223 – 242	20	Cytoplasmic Potential
	Transmembrane	243 – 263	21	Helical; Name=6; Potential
	Topological domain	264 – 284	21	Extracellular Potential
	Transmembrane	285 – 305	21	Helical; Name=7; Potential
	Topological domain	306 – 337	32	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	10	1	N-linked (GlcNAc...) Potential
	Glycosylation	23	1	N-linked (GlcNAc...) Potential
	Glycosylation	176	1	N-linked (GlcNAc...) Potential
	Glycosylation	179	1	N-linked (GlcNAc...) Potential
	Disulfide bond	106 ↔ 183		By similarity
Experimental info
	Sequence conflict	14	1	F → L in CAC83857. Ref.5
	Sequence conflict	236	1	K → R in CAC83857. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Q96P68 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 6814EA0044756CE6	FASTA	337	38,251
	10 20 30 40 50 60 MNEPLDYLAN ASDFPDYAAA FGNCTDENIP LKMHYLPVIY GIIFLVGFPG NAVVISTYIF 70 80 90 100 110 120 KMRPWKSSTI IMLNLACTDL LYLTSLPFLI HYYASGENWI FGDFMCKFIR FSFHFNLYSS 130 140 150 160 170 180 ILFLTCFSIF RYCVIIHPMS CFSIHKTRCA VVACAVVWII SLVAVIPMTF LITSTNRTNR 190 200 210 220 230 240 SACLDLTSSD ELNTIKWYNL ILTATTFCLP LVIVTLCYTT IIHTLTHGLQ TDSCLKQKAR 250 260 270 280 290 300 RLTILLLLAF YVCFLPFHIL RVIRIESRLL SISCSIENQI HEAYIVSRPL AALNTFGNLL 310 320 330 LYVVVSDNFQ QAVCSTVRCK VSGNLEQAKK ISYSNNP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Discovery and mapping of ten novel G protein-coupled receptor genes." Lee D.K., Nguyen T., Lynch K.R., Cheng R., Vanti W.B., Arkhitko O., Lewis T., Evans J.F., George S.R., O'Dowd B.F. Gene 275:83-91(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"GPR99, a new G protein-coupled receptor with homology to a new subgroup of nucleotide receptors." Wittenberger T., Hellebrand S., Munck A., Kreienkamp H.-J., Schaller H.C., Hampe W. BMC Genomics 3:17-17(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Placenta.
[3]	"Identification of G protein-coupled receptor genes from the human genome sequence." Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S. FEBS Lett. 520:97-101(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes." Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]	"Molecular cloning and functional characterization of a new human P2Y receptor." Bruess M., Bonisch H., von Kugelgen I. Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Thyroid.
[6]	"The DNA sequence and analysis of human chromosome 13." Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T. Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF411109 Genomic DNA. Translation: AAL26480.1. AF370886 mRNA. Translation: AAM76912.1. AB083598 Genomic DNA. Translation: BAB89311.1. AB065877 Genomic DNA. Translation: BAC06095.1. AJ305372 mRNA. Translation: CAC83857.1. AL356486 Genomic DNA. Translation: CAI16508.1. BC103881 mRNA. Translation: AAI03882.1. BC103882 mRNA. Translation: AAI03883.1. BC103883 mRNA. Translation: AAI03884.1.
IPI	IPI00044282.
RefSeq	NP_543008.3. NM_080818.3.
UniGene	Hs.352218.
3D structure databases
ProteinModelPortal	Q96P68.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000298440.
Protein family/group databases
GPCRDB	Search...
Polymorphism databases
DMDM	48474598.
Proteomic databases
PRIDE	Q96P68.
Protocols and materials databases
DNASU	27199.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000298440; ENSP00000298440; ENSG00000165621. ENST00000543457; ENSP00000438800; ENSG00000165621.
GeneID	27199.
KEGG	hsa:27199.
UCSC	uc001vmx.1. human.
Organism-specific databases
CTD	27199.
GeneCards	GC13M097637.
HGNC	HGNC:4531. OXGR1.
MIM	606922. gene.
neXtProt	NX_Q96P68.
PharmGKB	PA28924.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG146579.
HOGENOM	HOG000231307.
HOVERGEN	HBG106870.
InParanoid	Q96P68.
KO	K08419.
OMA	GFHFNLY.
OrthoDB	EOG46HGBH.
PhylomeDB	Q96P68.
Gene expression databases
ArrayExpress	Q96P68.
Bgee	Q96P68.
CleanEx	HS_OXGR1.
Genevestigator	Q96P68.
GermOnline	ENSG00000165621. Homo sapiens.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR002286. P2_purnocptor. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR01157. P2YPURNOCPTR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. False negative. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	27199.
NextBio	50066.
SOURCE	Search...

Entry information

Entry name

OXGR1_HUMAN

Accession

Primary (citable) accession number: Q96P68
Secondary accession number(s): Q5T5A7, Q86TL1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2003
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 97 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.