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Protein

2-oxoglutarate receptor 1

Gene

OXGR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for alpha-ketoglutarate. Seems to act exclusively through a G(q)-mediated pathway (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • G-protein coupled receptor signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_14828. Class A/1 (Rhodopsin-like receptors).
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate receptor 1
Alternative name(s):
Alpha-ketoglutarate receptor 1
G-protein coupled receptor 80
G-protein coupled receptor 99
P2Y purinoceptor 15
Short name:
P2Y15
P2Y-like GPCR
P2Y-like nucleotide receptor
Gene namesi
Name:OXGR1
Synonyms:GPR80, GPR99, P2RY15, P2Y15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:4531. OXGR1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3434ExtracellularSequence AnalysisAdd
BLAST
Transmembranei35 – 5521Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini56 – 6914CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei70 – 9021Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini91 – 11626ExtracellularSequence AnalysisAdd
BLAST
Transmembranei117 – 13721Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini138 – 15114CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei152 – 17221Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini173 – 20129ExtracellularSequence AnalysisAdd
BLAST
Transmembranei202 – 22221Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini223 – 24220CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei243 – 26321Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini264 – 28421ExtracellularSequence AnalysisAdd
BLAST
Transmembranei285 – 30521Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini306 – 33732CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28924.

Polymorphism and mutation databases

BioMutaiOXGR1.
DMDMi48474598.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3373372-oxoglutarate receptor 1PRO_0000069994Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi10 – 101N-linked (GlcNAc...)Sequence Analysis
Glycosylationi23 – 231N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi106 ↔ 183PROSITE-ProRule annotation
Glycosylationi176 – 1761N-linked (GlcNAc...)Sequence Analysis
Glycosylationi179 – 1791N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ96P68.

Expressioni

Tissue specificityi

Detected in kidney and, to a lower extend, in placenta. Not detected in brain tissues including the frontal cortex, caudate putamen, thalamus, hypothalamus, hippocampus or pons.

Gene expression databases

BgeeiQ96P68.
CleanExiHS_OXGR1.
ExpressionAtlasiQ96P68. baseline.
GenevisibleiQ96P68. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000298440.

Structurei

3D structure databases

ProteinModelPortaliQ96P68.
SMRiQ96P68. Positions 24-312.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG146579.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000231307.
HOVERGENiHBG106870.
InParanoidiQ96P68.
KOiK08419.
OMAiCKFIRFG.
OrthoDBiEOG7Z95MM.
PhylomeDBiQ96P68.
TreeFamiTF330775.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96P68-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNEPLDYLAN ASDFPDYAAA FGNCTDENIP LKMHYLPVIY GIIFLVGFPG
60 70 80 90 100
NAVVISTYIF KMRPWKSSTI IMLNLACTDL LYLTSLPFLI HYYASGENWI
110 120 130 140 150
FGDFMCKFIR FSFHFNLYSS ILFLTCFSIF RYCVIIHPMS CFSIHKTRCA
160 170 180 190 200
VVACAVVWII SLVAVIPMTF LITSTNRTNR SACLDLTSSD ELNTIKWYNL
210 220 230 240 250
ILTATTFCLP LVIVTLCYTT IIHTLTHGLQ TDSCLKQKAR RLTILLLLAF
260 270 280 290 300
YVCFLPFHIL RVIRIESRLL SISCSIENQI HEAYIVSRPL AALNTFGNLL
310 320 330
LYVVVSDNFQ QAVCSTVRCK VSGNLEQAKK ISYSNNP
Length:337
Mass (Da):38,251
Last modified:December 1, 2001 - v1
Checksum:i6814EA0044756CE6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti14 – 141F → L in CAC83857 (Ref. 5) Curated
Sequence conflicti236 – 2361K → R in CAC83857 (Ref. 5) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF411109 Genomic DNA. Translation: AAL26480.1.
AF370886 mRNA. Translation: AAM76912.1.
AB083598 Genomic DNA. Translation: BAB89311.1.
AB065877 Genomic DNA. Translation: BAC06095.1.
AJ305372 mRNA. Translation: CAC83857.1.
AL356486 Genomic DNA. Translation: CAI16508.1.
BC103881 mRNA. Translation: AAI03882.1.
BC103882 mRNA. Translation: AAI03883.1.
BC103883 mRNA. Translation: AAI03884.1.
CCDSiCCDS9482.1.
RefSeqiNP_543008.3. NM_080818.3.
XP_005254100.1. XM_005254043.2.
XP_005254101.1. XM_005254044.2.
XP_005254102.1. XM_005254045.1.
XP_005254103.1. XM_005254046.1.
UniGeneiHs.352218.

Genome annotation databases

EnsembliENST00000298440; ENSP00000298440; ENSG00000165621.
ENST00000543457; ENSP00000438800; ENSG00000165621.
GeneIDi27199.
KEGGihsa:27199.
UCSCiuc001vmx.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF411109 Genomic DNA. Translation: AAL26480.1.
AF370886 mRNA. Translation: AAM76912.1.
AB083598 Genomic DNA. Translation: BAB89311.1.
AB065877 Genomic DNA. Translation: BAC06095.1.
AJ305372 mRNA. Translation: CAC83857.1.
AL356486 Genomic DNA. Translation: CAI16508.1.
BC103881 mRNA. Translation: AAI03882.1.
BC103882 mRNA. Translation: AAI03883.1.
BC103883 mRNA. Translation: AAI03884.1.
CCDSiCCDS9482.1.
RefSeqiNP_543008.3. NM_080818.3.
XP_005254100.1. XM_005254043.2.
XP_005254101.1. XM_005254044.2.
XP_005254102.1. XM_005254045.1.
XP_005254103.1. XM_005254046.1.
UniGeneiHs.352218.

3D structure databases

ProteinModelPortaliQ96P68.
SMRiQ96P68. Positions 24-312.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000298440.

Chemistry

BindingDBiQ96P68.
ChEMBLiCHEMBL2150840.
GuidetoPHARMACOLOGYi162.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOXGR1.
DMDMi48474598.

Proteomic databases

PRIDEiQ96P68.

Protocols and materials databases

DNASUi27199.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000298440; ENSP00000298440; ENSG00000165621.
ENST00000543457; ENSP00000438800; ENSG00000165621.
GeneIDi27199.
KEGGihsa:27199.
UCSCiuc001vmx.1. human.

Organism-specific databases

CTDi27199.
GeneCardsiGC13M097637.
HGNCiHGNC:4531. OXGR1.
MIMi606922. gene.
neXtProtiNX_Q96P68.
PharmGKBiPA28924.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG146579.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000231307.
HOVERGENiHBG106870.
InParanoidiQ96P68.
KOiK08419.
OMAiCKFIRFG.
OrthoDBiEOG7Z95MM.
PhylomeDBiQ96P68.
TreeFamiTF330775.

Enzyme and pathway databases

ReactomeiREACT_14828. Class A/1 (Rhodopsin-like receptors).
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikiiOXGR1.
GenomeRNAii27199.
NextBioi50066.
PROiQ96P68.
SOURCEiSearch...

Gene expression databases

BgeeiQ96P68.
CleanExiHS_OXGR1.
ExpressionAtlasiQ96P68. baseline.
GenevisibleiQ96P68. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Discovery and mapping of ten novel G protein-coupled receptor genes."
    Lee D.K., Nguyen T., Lynch K.R., Cheng R., Vanti W.B., Arkhitko O., Lewis T., Evans J.F., George S.R., O'Dowd B.F.
    Gene 275:83-91(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "GPR99, a new G protein-coupled receptor with homology to a new subgroup of nucleotide receptors."
    Wittenberger T., Hellebrand S., Munck A., Kreienkamp H.-J., Schaller H.C., Hampe W.
    BMC Genomics 3:17-17(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Placenta.
  3. "Identification of G protein-coupled receptor genes from the human genome sequence."
    Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.
    FEBS Lett. 520:97-101(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "Molecular cloning and functional characterization of a new human P2Y receptor."
    Bruess M., Bonisch H., von Kugelgen I.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Thyroid.
  6. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiOXGR1_HUMAN
AccessioniPrimary (citable) accession number: Q96P68
Secondary accession number(s): Q5T5A7, Q86TL1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: December 1, 2001
Last modified: June 24, 2015
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Was originally (Ref. 5) thought to be a P2Y receptor.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.