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Q96P68 (OXGR1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
2-oxoglutarate receptor 1
Alternative name(s):
Alpha-ketoglutarate receptor 1
G-protein coupled receptor 80
G-protein coupled receptor 99
P2Y purinoceptor 15
Short name=P2Y15
P2Y-like GPCR
P2Y-like nucleotide receptor
Gene names
Name:OXGR1
Synonyms:GPR80, GPR99, P2RY15, P2Y15
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length337 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for alpha-ketoglutarate. Seems to act exclusively through a G(q)-mediated pathway By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Detected in kidney and, to a lower extend, in placenta. Not detected in brain tissues including the frontal cortex, caudate putamen, thalamus, hypothalamus, hippocampus or pons.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Caution

Was originally (Ref.5) thought to be a P2Y receptor.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3373372-oxoglutarate receptor 1
PRO_0000069994

Regions

Topological domain1 – 3434Extracellular Potential
Transmembrane35 – 5521Helical; Name=1; Potential
Topological domain56 – 6914Cytoplasmic Potential
Transmembrane70 – 9021Helical; Name=2; Potential
Topological domain91 – 11626Extracellular Potential
Transmembrane117 – 13721Helical; Name=3; Potential
Topological domain138 – 15114Cytoplasmic Potential
Transmembrane152 – 17221Helical; Name=4; Potential
Topological domain173 – 20129Extracellular Potential
Transmembrane202 – 22221Helical; Name=5; Potential
Topological domain223 – 24220Cytoplasmic Potential
Transmembrane243 – 26321Helical; Name=6; Potential
Topological domain264 – 28421Extracellular Potential
Transmembrane285 – 30521Helical; Name=7; Potential
Topological domain306 – 33732Cytoplasmic Potential

Amino acid modifications

Glycosylation101N-linked (GlcNAc...) Potential
Glycosylation231N-linked (GlcNAc...) Potential
Glycosylation1761N-linked (GlcNAc...) Potential
Glycosylation1791N-linked (GlcNAc...) Potential
Disulfide bond106 ↔ 183 By similarity

Experimental info

Sequence conflict141F → L in CAC83857. Ref.5
Sequence conflict2361K → R in CAC83857. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Q96P68 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 6814EA0044756CE6

FASTA33738,251
        10         20         30         40         50         60 
MNEPLDYLAN ASDFPDYAAA FGNCTDENIP LKMHYLPVIY GIIFLVGFPG NAVVISTYIF 

        70         80         90        100        110        120 
KMRPWKSSTI IMLNLACTDL LYLTSLPFLI HYYASGENWI FGDFMCKFIR FSFHFNLYSS 

       130        140        150        160        170        180 
ILFLTCFSIF RYCVIIHPMS CFSIHKTRCA VVACAVVWII SLVAVIPMTF LITSTNRTNR 

       190        200        210        220        230        240 
SACLDLTSSD ELNTIKWYNL ILTATTFCLP LVIVTLCYTT IIHTLTHGLQ TDSCLKQKAR 

       250        260        270        280        290        300 
RLTILLLLAF YVCFLPFHIL RVIRIESRLL SISCSIENQI HEAYIVSRPL AALNTFGNLL 

       310        320        330 
LYVVVSDNFQ QAVCSTVRCK VSGNLEQAKK ISYSNNP 

« Hide

References

« Hide 'large scale' references
[1]"Discovery and mapping of ten novel G protein-coupled receptor genes."
Lee D.K., Nguyen T., Lynch K.R., Cheng R., Vanti W.B., Arkhitko O., Lewis T., Evans J.F., George S.R., O'Dowd B.F.
Gene 275:83-91(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"GPR99, a new G protein-coupled receptor with homology to a new subgroup of nucleotide receptors."
Wittenberger T., Hellebrand S., Munck A., Kreienkamp H.-J., Schaller H.C., Hampe W.
BMC Genomics 3:17-17(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Placenta.
[3]"Identification of G protein-coupled receptor genes from the human genome sequence."
Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.
FEBS Lett. 520:97-101(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]"Molecular cloning and functional characterization of a new human P2Y receptor."
Bruess M., Bonisch H., von Kugelgen I.
Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Thyroid.
[6]"The DNA sequence and analysis of human chromosome 13."
Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF411109 Genomic DNA. Translation: AAL26480.1.
AF370886 mRNA. Translation: AAM76912.1.
AB083598 Genomic DNA. Translation: BAB89311.1.
AB065877 Genomic DNA. Translation: BAC06095.1.
AJ305372 mRNA. Translation: CAC83857.1.
AL356486 Genomic DNA. Translation: CAI16508.1.
BC103881 mRNA. Translation: AAI03882.1.
BC103882 mRNA. Translation: AAI03883.1.
BC103883 mRNA. Translation: AAI03884.1.
RefSeqNP_543008.3. NM_080818.3.
XP_005254100.1. XM_005254043.1.
XP_005254101.1. XM_005254044.1.
XP_005254102.1. XM_005254045.1.
XP_005254103.1. XM_005254046.1.
UniGeneHs.352218.

3D structure databases

ProteinModelPortalQ96P68.
SMRQ96P68. Positions 1-312.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000298440.

Chemistry

ChEMBLCHEMBL2150840.
GuidetoPHARMACOLOGY162.

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM48474598.

Proteomic databases

PRIDEQ96P68.

Protocols and materials databases

DNASU27199.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000298440; ENSP00000298440; ENSG00000165621.
ENST00000543457; ENSP00000438800; ENSG00000165621.
GeneID27199.
KEGGhsa:27199.
UCSCuc001vmx.1. human.

Organism-specific databases

CTD27199.
GeneCardsGC13M097637.
HGNCHGNC:4531. OXGR1.
MIM606922. gene.
neXtProtNX_Q96P68.
PharmGKBPA28924.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG146579.
HOGENOMHOG000231307.
HOVERGENHBG106870.
InParanoidQ96P68.
KOK08419.
OMAGFHFNLY.
OrthoDBEOG7Z95MM.
PhylomeDBQ96P68.
TreeFamTF330775.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressQ96P68.
BgeeQ96P68.
CleanExHS_OXGR1.
GenevestigatorQ96P68.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOXGR1.
GenomeRNAi27199.
NextBio50066.
PROQ96P68.
SOURCESearch...

Entry information

Entry nameOXGR1_HUMAN
AccessionPrimary (citable) accession number: Q96P68
Secondary accession number(s): Q5T5A7, Q86TL1
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 13

Human chromosome 13: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries