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Protein

Probable G-protein coupled receptor 82

Gene

GPR82

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171657-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 82
Gene namesi
Name:GPR82
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:4533. GPR82.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 11ExtracellularSequence analysisAdd BLAST11
Transmembranei12 – 32Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini33 – 55CytoplasmicSequence analysisAdd BLAST23
Transmembranei56 – 76Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini77 – 92ExtracellularSequence analysisAdd BLAST16
Transmembranei93 – 115Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini116 – 156CytoplasmicSequence analysisAdd BLAST41
Transmembranei157 – 177Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini178 – 197ExtracellularSequence analysisAdd BLAST20
Transmembranei198 – 218Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini219 – 251CytoplasmicSequence analysisAdd BLAST33
Transmembranei252 – 272Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini273 – 336ExtracellularSequence analysisAdd BLAST64

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000171657.
PharmGKBiPA28926.

Polymorphism and mutation databases

BioMutaiGPR82.
DMDMi27734323.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000695881 – 336Probable G-protein coupled receptor 82Add BLAST336

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...)Sequence analysis1
Glycosylationi4N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ96P67.
PRIDEiQ96P67.

PTM databases

iPTMnetiQ96P67.
PhosphoSitePlusiQ96P67.

Expressioni

Gene expression databases

BgeeiENSG00000171657.
CleanExiHS_GPR82.
GenevisibleiQ96P67. HS.

Organism-specific databases

HPAiHPA035914.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000303549.

Structurei

3D structure databases

ProteinModelPortaliQ96P67.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IISC. Eukaryota.
ENOG4111JUU. LUCA.
GeneTreeiENSGT00640000091213.
HOGENOMiHOG000112792.
HOVERGENiHBG097852.
InParanoidiQ96P67.
KOiK08420.
OMAiRYATLMK.
OrthoDBiEOG091G0DEZ.
PhylomeDBiQ96P67.
TreeFamiTF337127.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96P67-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNNTTCIQP SMISSMALPI IYILLCIVGV FGNTLSQWIF LTKIGKKTST
60 70 80 90 100
HIYLSHLVTA NLLVCSAMPF MSIYFLKGFQ WEYQSAQCRV VNFLGTLSMH
110 120 130 140 150
ASMFVSLLIL SWIAISRYAT LMQKDSSQET TSCYEKIFYG HLLKKFRQPN
160 170 180 190 200
FARKLCIYIW GVVLGIIIPV TVYYSVIEAT EGEESLCYNR QMELGAMISQ
210 220 230 240 250
IAGLIGTTFI GFSFLVVLTS YYSFVSHLRK IRTCTSIMEK DLTYSSVKRH
260 270 280 290 300
LLVIQILLIV CFLPYSIFKP IFYVLHQRDN CQQLNYLIET KNILTCLASA
310 320 330
RSSTDPIIFL LLDKTFKKTL YNLFTKSNSA HMQSYG
Length:336
Mass (Da):38,409
Last modified:December 1, 2001 - v1
Checksum:iB7691CA18B5824A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF411111 Genomic DNA. Translation: AAL26482.1.
AB065935 Genomic DNA. Translation: BAC06150.1.
AJ319076 mRNA. Translation: CAC87490.1.
JQ308170 Genomic DNA. Translation: AFF59480.1.
AB083595 Genomic DNA. Translation: BAB89308.1.
AK313702 mRNA. Translation: BAG36448.1.
AK122626 mRNA. Translation: BAG53628.1.
AL627402 Genomic DNA. Translation: CAH71243.1.
CH471141 Genomic DNA. Translation: EAW59395.1.
BC070180 mRNA. Translation: AAH70180.1.
CCDSiCCDS14259.1.
RefSeqiNP_543007.1. NM_080817.4.
XP_016884903.1. XM_017029414.1.
UniGeneiHs.567457.

Genome annotation databases

EnsembliENST00000302548; ENSP00000303549; ENSG00000171657.
GeneIDi27197.
KEGGihsa:27197.
UCSCiuc004dft.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF411111 Genomic DNA. Translation: AAL26482.1.
AB065935 Genomic DNA. Translation: BAC06150.1.
AJ319076 mRNA. Translation: CAC87490.1.
JQ308170 Genomic DNA. Translation: AFF59480.1.
AB083595 Genomic DNA. Translation: BAB89308.1.
AK313702 mRNA. Translation: BAG36448.1.
AK122626 mRNA. Translation: BAG53628.1.
AL627402 Genomic DNA. Translation: CAH71243.1.
CH471141 Genomic DNA. Translation: EAW59395.1.
BC070180 mRNA. Translation: AAH70180.1.
CCDSiCCDS14259.1.
RefSeqiNP_543007.1. NM_080817.4.
XP_016884903.1. XM_017029414.1.
UniGeneiHs.567457.

3D structure databases

ProteinModelPortaliQ96P67.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000303549.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ96P67.
PhosphoSitePlusiQ96P67.

Polymorphism and mutation databases

BioMutaiGPR82.
DMDMi27734323.

Proteomic databases

PaxDbiQ96P67.
PRIDEiQ96P67.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302548; ENSP00000303549; ENSG00000171657.
GeneIDi27197.
KEGGihsa:27197.
UCSCiuc004dft.3. human.

Organism-specific databases

CTDi27197.
GeneCardsiGPR82.
HGNCiHGNC:4533. GPR82.
HPAiHPA035914.
MIMi300748. gene.
neXtProtiNX_Q96P67.
OpenTargetsiENSG00000171657.
PharmGKBiPA28926.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IISC. Eukaryota.
ENOG4111JUU. LUCA.
GeneTreeiENSGT00640000091213.
HOGENOMiHOG000112792.
HOVERGENiHBG097852.
InParanoidiQ96P67.
KOiK08420.
OMAiRYATLMK.
OrthoDBiEOG091G0DEZ.
PhylomeDBiQ96P67.
TreeFamiTF337127.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171657-MONOMER.

Miscellaneous databases

GeneWikiiGPR82.
GenomeRNAii27197.
PROiQ96P67.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000171657.
CleanExiHS_GPR82.
GenevisibleiQ96P67. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPR82_HUMAN
AccessioniPrimary (citable) accession number: Q96P67
Secondary accession number(s): Q5VT13
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.