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Protein

Probable G-protein coupled receptor 82

Gene

GPR82

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 82
Gene namesi
Name:GPR82
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:4533. GPR82.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1111ExtracellularSequence AnalysisAdd
BLAST
Transmembranei12 – 3221Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini33 – 5523CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei56 – 7621Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini77 – 9216ExtracellularSequence AnalysisAdd
BLAST
Transmembranei93 – 11523Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini116 – 15641CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei157 – 17721Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini178 – 19720ExtracellularSequence AnalysisAdd
BLAST
Transmembranei198 – 21821Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini219 – 25133CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei252 – 27221Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini273 – 33664ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28926.

Polymorphism and mutation databases

BioMutaiGPR82.
DMDMi27734323.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 336336Probable G-protein coupled receptor 82PRO_0000069588Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence Analysis
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ96P67.
PRIDEiQ96P67.

PTM databases

PhosphoSiteiQ96P67.

Expressioni

Gene expression databases

BgeeiQ96P67.
CleanExiHS_GPR82.
GenevestigatoriQ96P67.

Organism-specific databases

HPAiHPA035914.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000303549.

Structurei

3D structure databases

ProteinModelPortaliQ96P67.
SMRiQ96P67. Positions 11-323.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG151131.
GeneTreeiENSGT00640000091213.
HOGENOMiHOG000112792.
HOVERGENiHBG097852.
InParanoidiQ96P67.
KOiK08420.
OMAiTANLLVC.
OrthoDBiEOG7DFXCZ.
PhylomeDBiQ96P67.
TreeFamiTF337127.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96P67-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNNTTCIQP SMISSMALPI IYILLCIVGV FGNTLSQWIF LTKIGKKTST
60 70 80 90 100
HIYLSHLVTA NLLVCSAMPF MSIYFLKGFQ WEYQSAQCRV VNFLGTLSMH
110 120 130 140 150
ASMFVSLLIL SWIAISRYAT LMQKDSSQET TSCYEKIFYG HLLKKFRQPN
160 170 180 190 200
FARKLCIYIW GVVLGIIIPV TVYYSVIEAT EGEESLCYNR QMELGAMISQ
210 220 230 240 250
IAGLIGTTFI GFSFLVVLTS YYSFVSHLRK IRTCTSIMEK DLTYSSVKRH
260 270 280 290 300
LLVIQILLIV CFLPYSIFKP IFYVLHQRDN CQQLNYLIET KNILTCLASA
310 320 330
RSSTDPIIFL LLDKTFKKTL YNLFTKSNSA HMQSYG
Length:336
Mass (Da):38,409
Last modified:December 1, 2001 - v1
Checksum:iB7691CA18B5824A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF411111 Genomic DNA. Translation: AAL26482.1.
AB065935 Genomic DNA. Translation: BAC06150.1.
AJ319076 mRNA. Translation: CAC87490.1.
JQ308170 Genomic DNA. Translation: AFF59480.1.
AB083595 Genomic DNA. Translation: BAB89308.1.
AK313702 mRNA. Translation: BAG36448.1.
AK122626 mRNA. Translation: BAG53628.1.
AL627402 Genomic DNA. Translation: CAH71243.1.
CH471141 Genomic DNA. Translation: EAW59395.1.
BC070180 mRNA. Translation: AAH70180.1.
CCDSiCCDS14259.1.
RefSeqiNP_543007.1. NM_080817.4.
UniGeneiHs.567457.

Genome annotation databases

EnsembliENST00000302548; ENSP00000303549; ENSG00000171657.
GeneIDi27197.
KEGGihsa:27197.
UCSCiuc004dft.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF411111 Genomic DNA. Translation: AAL26482.1.
AB065935 Genomic DNA. Translation: BAC06150.1.
AJ319076 mRNA. Translation: CAC87490.1.
JQ308170 Genomic DNA. Translation: AFF59480.1.
AB083595 Genomic DNA. Translation: BAB89308.1.
AK313702 mRNA. Translation: BAG36448.1.
AK122626 mRNA. Translation: BAG53628.1.
AL627402 Genomic DNA. Translation: CAH71243.1.
CH471141 Genomic DNA. Translation: EAW59395.1.
BC070180 mRNA. Translation: AAH70180.1.
CCDSiCCDS14259.1.
RefSeqiNP_543007.1. NM_080817.4.
UniGeneiHs.567457.

3D structure databases

ProteinModelPortaliQ96P67.
SMRiQ96P67. Positions 11-323.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000303549.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ96P67.

Polymorphism and mutation databases

BioMutaiGPR82.
DMDMi27734323.

Proteomic databases

PaxDbiQ96P67.
PRIDEiQ96P67.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302548; ENSP00000303549; ENSG00000171657.
GeneIDi27197.
KEGGihsa:27197.
UCSCiuc004dft.3. human.

Organism-specific databases

CTDi27197.
GeneCardsiGC0XP041583.
HGNCiHGNC:4533. GPR82.
HPAiHPA035914.
MIMi300748. gene.
neXtProtiNX_Q96P67.
PharmGKBiPA28926.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG151131.
GeneTreeiENSGT00640000091213.
HOGENOMiHOG000112792.
HOVERGENiHBG097852.
InParanoidiQ96P67.
KOiK08420.
OMAiTANLLVC.
OrthoDBiEOG7DFXCZ.
PhylomeDBiQ96P67.
TreeFamiTF337127.

Miscellaneous databases

GeneWikiiGPR82.
GenomeRNAii27197.
NextBioi50058.
PROiQ96P67.
SOURCEiSearch...

Gene expression databases

BgeeiQ96P67.
CleanExiHS_GPR82.
GenevestigatoriQ96P67.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Discovery and mapping of ten novel G protein-coupled receptor genes."
    Lee D.K., Nguyen T., Lynch K.R., Cheng R., Vanti W.B., Arkhitko O., Lewis T., Evans J.F., George S.R., O'Dowd B.F.
    Gene 275:83-91(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Identification and functional characterization of a novel G protein-coupled nucleotide-/nucleoside receptor."
    von Kugelgen I., Bonisch H., Bruss M.
    Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Placenta.
  3. "Isolation of intronless coding regions from genomic DNA of 4 human genes."
    Kaighin V.A., Martin A.L., Aronstam R.S.
    Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "Identification of G protein-coupled receptor genes from the human genome sequence."
    Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.
    FEBS Lett. 520:97-101(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thyroid.

Entry informationi

Entry nameiGPR82_HUMAN
AccessioniPrimary (citable) accession number: Q96P67
Secondary accession number(s): Q5VT13
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: December 1, 2001
Last modified: May 27, 2015
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.