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Q96P67

- GPR82_HUMAN

UniProt

Q96P67 - GPR82_HUMAN

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Protein
Probable G-protein coupled receptor 82
Gene
GPR82
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable G-protein coupled receptor 82
    Gene namesi
    Name:GPR82
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:4533. GPR82.

    Subcellular locationi

    Topology

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1111Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei12 – 3221Helical; Name=1; Reviewed prediction
    Add
    BLAST
    Topological domaini33 – 5523Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei56 – 7621Helical; Name=2; Reviewed prediction
    Add
    BLAST
    Topological domaini77 – 9216Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei93 – 11523Helical; Name=3; Reviewed prediction
    Add
    BLAST
    Topological domaini116 – 15641Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei157 – 17721Helical; Name=4; Reviewed prediction
    Add
    BLAST
    Topological domaini178 – 19720Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei198 – 21821Helical; Name=5; Reviewed prediction
    Add
    BLAST
    Topological domaini219 – 25133Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei252 – 27221Helical; Name=6; Reviewed prediction
    Add
    BLAST
    Topological domaini273 – 33664Extracellular Reviewed prediction
    Add
    BLAST

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28926.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 336336Probable G-protein coupled receptor 82
    PRO_0000069588Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi3 – 31N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi4 – 41N-linked (GlcNAc...) Reviewed prediction

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ96P67.
    PRIDEiQ96P67.

    PTM databases

    PhosphoSiteiQ96P67.

    Expressioni

    Gene expression databases

    BgeeiQ96P67.
    CleanExiHS_GPR82.
    GenevestigatoriQ96P67.

    Organism-specific databases

    HPAiHPA035914.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000303549.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96P67.
    SMRiQ96P67. Positions 11-328.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG151131.
    HOGENOMiHOG000112792.
    HOVERGENiHBG097852.
    InParanoidiQ96P67.
    KOiK08420.
    OMAiHVSMFVS.
    OrthoDBiEOG7DFXCZ.
    PhylomeDBiQ96P67.
    TreeFamiTF337127.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96P67-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNNNTTCIQP SMISSMALPI IYILLCIVGV FGNTLSQWIF LTKIGKKTST    50
    HIYLSHLVTA NLLVCSAMPF MSIYFLKGFQ WEYQSAQCRV VNFLGTLSMH 100
    ASMFVSLLIL SWIAISRYAT LMQKDSSQET TSCYEKIFYG HLLKKFRQPN 150
    FARKLCIYIW GVVLGIIIPV TVYYSVIEAT EGEESLCYNR QMELGAMISQ 200
    IAGLIGTTFI GFSFLVVLTS YYSFVSHLRK IRTCTSIMEK DLTYSSVKRH 250
    LLVIQILLIV CFLPYSIFKP IFYVLHQRDN CQQLNYLIET KNILTCLASA 300
    RSSTDPIIFL LLDKTFKKTL YNLFTKSNSA HMQSYG 336
    Length:336
    Mass (Da):38,409
    Last modified:December 1, 2001 - v1
    Checksum:iB7691CA18B5824A4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF411111 Genomic DNA. Translation: AAL26482.1.
    AB065935 Genomic DNA. Translation: BAC06150.1.
    AJ319076 mRNA. Translation: CAC87490.1.
    JQ308170 Genomic DNA. Translation: AFF59480.1.
    AB083595 Genomic DNA. Translation: BAB89308.1.
    AK313702 mRNA. Translation: BAG36448.1.
    AK122626 mRNA. Translation: BAG53628.1.
    AL627402 Genomic DNA. Translation: CAH71243.1.
    CH471141 Genomic DNA. Translation: EAW59395.1.
    BC070180 mRNA. Translation: AAH70180.1.
    CCDSiCCDS14259.1.
    RefSeqiNP_543007.1. NM_080817.4.
    UniGeneiHs.567457.

    Genome annotation databases

    EnsembliENST00000302548; ENSP00000303549; ENSG00000171657.
    GeneIDi27197.
    KEGGihsa:27197.
    UCSCiuc004dft.3. human.

    Polymorphism databases

    DMDMi27734323.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF411111 Genomic DNA. Translation: AAL26482.1 .
    AB065935 Genomic DNA. Translation: BAC06150.1 .
    AJ319076 mRNA. Translation: CAC87490.1 .
    JQ308170 Genomic DNA. Translation: AFF59480.1 .
    AB083595 Genomic DNA. Translation: BAB89308.1 .
    AK313702 mRNA. Translation: BAG36448.1 .
    AK122626 mRNA. Translation: BAG53628.1 .
    AL627402 Genomic DNA. Translation: CAH71243.1 .
    CH471141 Genomic DNA. Translation: EAW59395.1 .
    BC070180 mRNA. Translation: AAH70180.1 .
    CCDSi CCDS14259.1.
    RefSeqi NP_543007.1. NM_080817.4.
    UniGenei Hs.567457.

    3D structure databases

    ProteinModelPortali Q96P67.
    SMRi Q96P67. Positions 11-328.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000303549.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q96P67.

    Polymorphism databases

    DMDMi 27734323.

    Proteomic databases

    PaxDbi Q96P67.
    PRIDEi Q96P67.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000302548 ; ENSP00000303549 ; ENSG00000171657 .
    GeneIDi 27197.
    KEGGi hsa:27197.
    UCSCi uc004dft.3. human.

    Organism-specific databases

    CTDi 27197.
    GeneCardsi GC0XP041583.
    HGNCi HGNC:4533. GPR82.
    HPAi HPA035914.
    MIMi 300748. gene.
    neXtProti NX_Q96P67.
    PharmGKBi PA28926.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG151131.
    HOGENOMi HOG000112792.
    HOVERGENi HBG097852.
    InParanoidi Q96P67.
    KOi K08420.
    OMAi HVSMFVS.
    OrthoDBi EOG7DFXCZ.
    PhylomeDBi Q96P67.
    TreeFami TF337127.

    Miscellaneous databases

    GeneWikii GPR82.
    GenomeRNAii 27197.
    NextBioi 50058.
    PROi Q96P67.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q96P67.
    CleanExi HS_GPR82.
    Genevestigatori Q96P67.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "Discovery and mapping of ten novel G protein-coupled receptor genes."
      Lee D.K., Nguyen T., Lynch K.R., Cheng R., Vanti W.B., Arkhitko O., Lewis T., Evans J.F., George S.R., O'Dowd B.F.
      Gene 275:83-91(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Identification and functional characterization of a novel G protein-coupled nucleotide-/nucleoside receptor."
      von Kugelgen I., Bonisch H., Bruss M.
      Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Placenta.
    3. "Isolation of intronless coding regions from genomic DNA of 4 human genes."
      Kaighin V.A., Martin A.L., Aronstam R.S.
      Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "Identification of G protein-coupled receptor genes from the human genome sequence."
      Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.
      FEBS Lett. 520:97-101(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Thyroid.

    Entry informationi

    Entry nameiGPR82_HUMAN
    AccessioniPrimary (citable) accession number: Q96P67
    Secondary accession number(s): Q5VT13
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2003
    Last sequence update: December 1, 2001
    Last modified: July 9, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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