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Protein

Probable G-protein coupled receptor 101

Gene

GPR101

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Orphan receptor.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 101
Gene namesi
Name:GPR101
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:14963. GPR101.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3535ExtracellularSequence analysisAdd
BLAST
Transmembranei36 – 5621Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini57 – 6812CytoplasmicSequence analysisAdd
BLAST
Transmembranei69 – 8921Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini90 – 10617ExtracellularSequence analysisAdd
BLAST
Transmembranei107 – 12721Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini128 – 14922CytoplasmicSequence analysisAdd
BLAST
Transmembranei150 – 17021Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini171 – 19626ExtracellularSequence analysisAdd
BLAST
Transmembranei197 – 21721Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini218 – 399182CytoplasmicSequence analysisAdd
BLAST
Transmembranei400 – 42021Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini421 – 43313ExtracellularSequence analysisAdd
BLAST
Transmembranei434 – 45421Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini455 – 50854CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Pituitary adenoma, growth hormone-secreting, 2 (PAGH2)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA growth hormone-secreting, benign neoplasm of the anterior pituitary gland, also known as somatotropinoma. It clinically results in acromegaly, a condition characterized by coarse facial features, protruding jaw, and enlarged extremities. Excessive production of growth hormone in children or adolescents before the closure of epiphyses causes gigantism, a condition characterized by abnormally tall stature.
See also OMIM:300943
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti308 – 3081E → D in PAGH2. 1 Publication
Corresponds to variant rs73637412 [ dbSNP | Ensembl ].
VAR_072691

Keywords - Diseasei

Disease mutation

Organism-specific databases

MalaCardsiGPR101.
MIMi300943. phenotype.
PharmGKBiPA28849.

Polymorphism and mutation databases

BioMutaiGPR101.
DMDMi48474929.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 508508Probable G-protein coupled receptor 101PRO_0000069601Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi7 – 71N-linked (GlcNAc...)Sequence analysis
Glycosylationi13 – 131N-linked (GlcNAc...)Sequence analysis
Disulfide bondi104 ↔ 182PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ96P66.
PeptideAtlasiQ96P66.
PRIDEiQ96P66.

PTM databases

iPTMnetiQ96P66.

Expressioni

Gene expression databases

BgeeiQ96P66.
CleanExiHS_GPR101.
GenevisibleiQ96P66. HS.

Organism-specific databases

HPAiHPA001084.

Interactioni

Protein-protein interaction databases

BioGridi123682. 2 interactions.
STRINGi9606.ENSP00000298110.

Structurei

3D structure databases

ProteinModelPortaliQ96P66.
SMRiQ96P66. Positions 31-457.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00790000123027.
HOGENOMiHOG000112760.
HOVERGENiHBG051766.
InParanoidiQ96P66.
KOiK08423.
OMAiSHFCTAL.
OrthoDBiEOG7N0C5C.
PhylomeDBiQ96P66.
TreeFamiTF331895.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96P66-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSTCTNSTR ESNSSHTCMP LSKMPISLAH GIIRSTVLVI FLAASFVGNI
60 70 80 90 100
VLALVLQRKP QLLQVTNRFI FNLLVTDLLQ ISLVAPWVVA TSVPLFWPLN
110 120 130 140 150
SHFCTALVSL THLFAFASVN TIVVVSVDRY LSIIHPLSYP SKMTQRRGYL
160 170 180 190 200
LLYGTWIVAI LQSTPPLYGW GQAAFDERNA LCSMIWGASP SYTILSVVSF
210 220 230 240 250
IVIPLIVMIA CYSVVFCAAR RQHALLYNVK RHSLEVRVKD CVENEDEEGA
260 270 280 290 300
EKKEEFQDES EFRRQHEGEV KAKEGRMEAK DGSLKAKEGS TGTSESSVEA
310 320 330 340 350
RGSEEVRESS TVASDGSMEG KEGSTKVEEN SMKADKGRTE VNQCSIDLGE
360 370 380 390 400
DDMEFGEDDI NFSEDDVEAV NIPESLPPSR RNSNSNPPLP RCYQCKAAKV
410 420 430 440 450
IFIIIFSYVL SLGPYCFLAV LAVWVDVETQ VPQWVITIII WLFFLQCCIH
460 470 480 490 500
PYVYGYMHKT IKKEIQDMLK KFFCKEKPPK EDSHPDLPGT EGGTEGKIVP

SYDSATFP
Length:508
Mass (Da):56,716
Last modified:December 1, 2001 - v1
Checksum:iE20A409F65C95BB5
GO

Sequence cautioni

The sequence BAC06152.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti124 – 1241V → L.
Corresponds to variant rs1190736 [ dbSNP | Ensembl ].
VAR_049398
Natural varianti308 – 3081E → D in PAGH2. 1 Publication
Corresponds to variant rs73637412 [ dbSNP | Ensembl ].
VAR_072691
Natural varianti376 – 3761L → P.
Corresponds to variant rs5931046 [ dbSNP | Ensembl ].
VAR_049399

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF411115 Genomic DNA. Translation: AAL26486.1.
AB083588 Genomic DNA. Translation: BAB89301.1.
AB065937 Genomic DNA. Translation: BAC06152.1. Different initiation.
AL390879 Genomic DNA. Translation: CAI40047.1.
CH471150 Genomic DNA. Translation: EAW88450.1.
BC069439 mRNA. Translation: AAH69439.1.
CCDSiCCDS14662.1.
RefSeqiNP_473362.1. NM_054021.1.
UniGeneiHs.350569.

Genome annotation databases

EnsembliENST00000298110; ENSP00000298110; ENSG00000165370.
GeneIDi83550.
KEGGihsa:83550.
UCSCiuc011mwh.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF411115 Genomic DNA. Translation: AAL26486.1.
AB083588 Genomic DNA. Translation: BAB89301.1.
AB065937 Genomic DNA. Translation: BAC06152.1. Different initiation.
AL390879 Genomic DNA. Translation: CAI40047.1.
CH471150 Genomic DNA. Translation: EAW88450.1.
BC069439 mRNA. Translation: AAH69439.1.
CCDSiCCDS14662.1.
RefSeqiNP_473362.1. NM_054021.1.
UniGeneiHs.350569.

3D structure databases

ProteinModelPortaliQ96P66.
SMRiQ96P66. Positions 31-457.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123682. 2 interactions.
STRINGi9606.ENSP00000298110.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ96P66.

Polymorphism and mutation databases

BioMutaiGPR101.
DMDMi48474929.

Proteomic databases

PaxDbiQ96P66.
PeptideAtlasiQ96P66.
PRIDEiQ96P66.

Protocols and materials databases

DNASUi83550.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000298110; ENSP00000298110; ENSG00000165370.
GeneIDi83550.
KEGGihsa:83550.
UCSCiuc011mwh.2. human.

Organism-specific databases

CTDi83550.
GeneCardsiGPR101.
HGNCiHGNC:14963. GPR101.
HPAiHPA001084.
MalaCardsiGPR101.
MIMi300393. gene.
300943. phenotype.
neXtProtiNX_Q96P66.
PharmGKBiPA28849.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00790000123027.
HOGENOMiHOG000112760.
HOVERGENiHBG051766.
InParanoidiQ96P66.
KOiK08423.
OMAiSHFCTAL.
OrthoDBiEOG7N0C5C.
PhylomeDBiQ96P66.
TreeFamiTF331895.

Miscellaneous databases

GeneWikiiGPR101.
GenomeRNAii83550.
PROiQ96P66.
SOURCEiSearch...

Gene expression databases

BgeeiQ96P66.
CleanExiHS_GPR101.
GenevisibleiQ96P66. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Discovery and mapping of ten novel G protein-coupled receptor genes."
    Lee D.K., Nguyen T., Lynch K.R., Cheng R., Vanti W.B., Arkhitko O., Lewis T., Evans J.F., George S.R., O'Dowd B.F.
    Gene 275:83-91(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Identification of G protein-coupled receptor genes from the human genome sequence."
    Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.
    FEBS Lett. 520:97-101(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  7. Cited for: INVOLVEMENT IN PAGH2, VARIANT PAGH2 ASP-308.

Entry informationi

Entry nameiGP101_HUMAN
AccessioniPrimary (citable) accession number: Q96P66
Secondary accession number(s): Q5JSM8, Q8NG93
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: December 1, 2001
Last modified: July 6, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.