ID   QRFPR_HUMAN             Reviewed;         431 AA.
AC   Q96P65;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2004, sequence version 2.
DT   24-JAN-2024, entry version 167.
DE   RecName: Full=Pyroglutamylated RF-amide peptide receptor;
DE   AltName: Full=AQ27;
DE   AltName: Full=G-protein coupled receptor 103;
DE   AltName: Full=Orexigenic neuropeptide QRFP receptor;
DE   AltName: Full=SP9155;
GN   Name=QRFPR; Synonyms=GPR103;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX   PubMed=11574155; DOI=10.1016/s0378-1119(01)00651-5;
RA   Lee D.K., Nguyen T., Lynch K.R., Cheng R., Vanti W.B., Arkhitko O.,
RA   Lewis T., Evans J.F., George S.R., O'Dowd B.F.;
RT   "Discovery and mapping of ten novel G protein-coupled receptor genes.";
RL   Gene 275:83-91(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX   PubMed=12714592; DOI=10.1074/jbc.m302945200;
RA   Jiang Y., Luo L., Gustafson E.L., Yadav D., Laverty M., Murgolo N.,
RA   Vassileva G., Zeng M., Laz T.M., Behan J., Qiu P., Wang L., Wang S.,
RA   Bayne M., Greene J., Monsma F.J. Jr., Zhang F.L.;
RT   "Identification and characterization of a novel RF-amide peptide ligand for
RT   orphan G-protein-coupled receptor SP9155.";
RL   J. Biol. Chem. 278:27652-27657(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RC   TISSUE=Fetal brain;
RX   PubMed=12960173; DOI=10.1074/jbc.m305270200;
RA   Fukusumi S., Yoshida H., Fujii R., Maruyama M., Komatsu H., Habata Y.,
RA   Shintani Y., Hinuma S., Fujino M.;
RT   "A new peptidic ligand and its receptor regulating adrenal function in
RT   rats.";
RL   J. Biol. Chem. 278:46387-46395(2003).
CC   -!- FUNCTION: Receptor for the orexigenic neuropeptide QRFP. The activity
CC       of this receptor is mediated by G proteins that modulate adenylate
CC       cyclase activity and intracellular calcium levels.
CC       {ECO:0000269|PubMed:12960173}.
CC   -!- INTERACTION:
CC       Q96P65; P48165: GJA8; NbExp=3; IntAct=EBI-12820497, EBI-17458373;
CC       Q96P65; Q9P121-3: NTM; NbExp=3; IntAct=EBI-12820497, EBI-12027160;
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Expressed widely in the brain with high levels in
CC       the hypothalamus, trigeminal ganglia and vestibular neurons, and
CC       moderate levels in the amygdala, cortex, pituitary, hippocampus,
CC       thalamus, caudate nucleus and medulla oblongata. In peripheral tissues,
CC       expressed at high levels in the retina and at moderate levels in the
CC       heart, kidney, testis and thyroid. {ECO:0000269|PubMed:11574155,
CC       ECO:0000269|PubMed:12714592}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAL26488.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AF411117; AAL26488.1; ALT_INIT; mRNA.
DR   EMBL; AB109629; BAC98938.1; -; mRNA.
DR   CCDS; CCDS3719.1; -.
DR   RefSeq; NP_937822.2; NM_198179.2.
DR   AlphaFoldDB; Q96P65; -.
DR   EMDB; EMD-33984; -.
DR   EMDB; EMD-33985; -.
DR   SMR; Q96P65; -.
DR   BioGRID; 123897; 3.
DR   IntAct; Q96P65; 2.
DR   STRING; 9606.ENSP00000377948; -.
DR   BindingDB; Q96P65; -.
DR   ChEMBL; CHEMBL5852; -.
DR   GuidetoPHARMACOLOGY; 333; -.
DR   GlyCosmos; Q96P65; 1 site, No reported glycans.
DR   GlyGen; Q96P65; 1 site.
DR   iPTMnet; Q96P65; -.
DR   PhosphoSitePlus; Q96P65; -.
DR   BioMuta; QRFPR; -.
DR   DMDM; 47117904; -.
DR   MassIVE; Q96P65; -.
DR   PaxDb; 9606-ENSP00000377948; -.
DR   PeptideAtlas; Q96P65; -.
DR   ProteomicsDB; 77639; -.
DR   Antibodypedia; 2965; 306 antibodies from 31 providers.
DR   DNASU; 84109; -.
DR   Ensembl; ENST00000394427.3; ENSP00000377948.2; ENSG00000186867.11.
DR   GeneID; 84109; -.
DR   KEGG; hsa:84109; -.
DR   MANE-Select; ENST00000394427.3; ENSP00000377948.2; NM_198179.3; NP_937822.2.
DR   UCSC; uc010inj.2; human.
DR   AGR; HGNC:15565; -.
DR   CTD; 84109; -.
DR   DisGeNET; 84109; -.
DR   GeneCards; QRFPR; -.
DR   HGNC; HGNC:15565; QRFPR.
DR   HPA; ENSG00000186867; Tissue enhanced (brain, heart muscle, kidney).
DR   MIM; 606925; gene.
DR   neXtProt; NX_Q96P65; -.
DR   OpenTargets; ENSG00000186867; -.
DR   PharmGKB; PA164725243; -.
DR   VEuPathDB; HostDB:ENSG00000186867; -.
DR   eggNOG; ENOG502QW2F; Eukaryota.
DR   GeneTree; ENSGT01070000253744; -.
DR   InParanoid; Q96P65; -.
DR   OMA; IHMMIEY; -.
DR   OrthoDB; 2877170at2759; -.
DR   PhylomeDB; Q96P65; -.
DR   TreeFam; TF315303; -.
DR   PathwayCommons; Q96P65; -.
DR   Reactome; R-HSA-389397; Orexin and neuropeptides FF and QRFP bind to their respective receptors.
DR   Reactome; R-HSA-416476; G alpha (q) signalling events.
DR   SignaLink; Q96P65; -.
DR   BioGRID-ORCS; 84109; 13 hits in 1143 CRISPR screens.
DR   ChiTaRS; QRFPR; human.
DR   GeneWiki; Pyroglutamylated_RFamide_peptide_receptor; -.
DR   GenomeRNAi; 84109; -.
DR   Pharos; Q96P65; Tchem.
DR   PRO; PR:Q96P65; -.
DR   Proteomes; UP000005640; Chromosome 4.
DR   RNAct; Q96P65; Protein.
DR   Bgee; ENSG00000186867; Expressed in primordial germ cell in gonad and 76 other cell types or tissues.
DR   ExpressionAtlas; Q96P65; baseline and differential.
DR   GO; GO:0016020; C:membrane; IC:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IDA:UniProtKB.
DR   GO; GO:0004983; F:neuropeptide Y receptor activity; IEA:InterPro.
DR   GO; GO:0042277; F:peptide binding; IBA:GO_Central.
DR   GO; GO:0032870; P:cellular response to hormone stimulus; IBA:GO_Central.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IDA:UniProtKB.
DR   CDD; cd15205; 7tmA_QRFPR; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000611; NPY_rcpt.
DR   PANTHER; PTHR24241; NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR; 1.
DR   PANTHER; PTHR24241:SF119; PYROGLUTAMYLATED RF-AMIDE PEPTIDE RECEPTOR; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR01012; NRPEPTIDEYR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR   Genevisible; Q96P65; HS.
PE   1: Evidence at protein level;
KW   Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW   Receptor; Reference proteome; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..431
FT                   /note="Pyroglutamylated RF-amide peptide receptor"
FT                   /id="PRO_0000070097"
FT   TOPO_DOM        1..46
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        47..67
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        68..81
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        82..102
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        103..120
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        121..141
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        142..162
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        163..183
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        184..212
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        213..233
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        234..271
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        272..292
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        293..311
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        312..332
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        333..431
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        19
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VARIANT         61
FT                   /note="F -> V (in dbSNP:rs17438900)"
FT                   /id="VAR_049437"
FT   VARIANT         149
FT                   /note="H -> Q (in dbSNP:rs11947418)"
FT                   /id="VAR_049438"
FT   VARIANT         344
FT                   /note="L -> S (in dbSNP:rs2302310)"
FT                   /id="VAR_049439"
FT   CONFLICT        28..29
FT                   /note="LY -> VH (in Ref. 3; BAC98938)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        220..266
FT                   /note="VILFLLPLMVMLILYSKIGYELWIKKRVGDGSVLRTIHGKEMSKIAR -> S
FT                   SSSSCLLW (in Ref. 1; AAL26488)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   431 AA;  49488 MW;  778D9AE70528024D CRC64;
     MQALNITPEQ FSRLLRDHNL TREQFIALYR LRPLVYTPEL PGRAKLALVL TGVLIFALAL
     FGNALVFYVV TRSKAMRTVT NIFICSLALS DLLITFFCIP VTMLQNISDN WLGGAFICKM
     VPFVQSTAVV TEILTMTCIA VERHQGLVHP FKMKWQYTNR RAFTMLGVVW LVAVIVGSPM
     WHVQQLEIKY DFLYEKEHIC CLEEWTSPVH QKIYTTFILV ILFLLPLMVM LILYSKIGYE
     LWIKKRVGDG SVLRTIHGKE MSKIARKKKR AVIMMVTVVA LFAVCWAPFH VVHMMIEYSN
     FEKEYDDVTI KMIFAIVQII GFSNSICNPI VYAFMNENFK KNVLSAVCYC IVNKTFSPAQ
     RHGNSGITMM RKKAKFSLRE NPVEETKGEA FSDGNIEVKL CEQTEEKKKL KRHLALFRSE
     LAENSPLDSG H
//